Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionprotein methyltransferase activity

FAM86B1 PRMT8 FAM86B2 KMT2B

7.06e-05103434GO:0008276
GeneOntologyMolecularFunctionN-methyltransferase activity

FAM86B1 PRMT8 FAM86B2 KMT2B

7.61e-05105434GO:0008170
GeneOntologyMolecularFunctionprotein-lysine N-methyltransferase activity

FAM86B1 FAM86B2 KMT2B

4.23e-0468433GO:0016279
GeneOntologyMolecularFunctionlysine N-methyltransferase activity

FAM86B1 FAM86B2 KMT2B

4.41e-0469433GO:0016278
GeneOntologyMolecularFunctionS-adenosylmethionine-dependent methyltransferase activity

FAM86B1 PRMT8 FAM86B2 KMT2B

5.05e-04172434GO:0008757
GeneOntologyMolecularFunctionmethyltransferase activity

FAM86B1 PRMT8 FAM86B2 KMT2B

1.12e-03213434GO:0008168
GeneOntologyMolecularFunctiontransferase activity, transferring one-carbon groups

FAM86B1 PRMT8 FAM86B2 KMT2B

1.35e-03224434GO:0016741
GeneOntologyMolecularFunctionactin filament binding

TRIOBP MYO1C VILL ADD1

1.42e-03227434GO:0051015
GeneOntologyMolecularFunctionligase activity, forming carbon-sulfur bonds

UBA6 AASDH

3.52e-0341432GO:0016877
GeneOntologyBiologicalProcessbarbed-end actin filament capping

TRIOBP VILL ADD1

3.18e-0529443GO:0051016
GeneOntologyBiologicalProcesscentral nervous system segmentation

ZIC2 ZIC3

4.43e-055442GO:0035283
GeneOntologyBiologicalProcessactin filament capping

TRIOBP VILL ADD1

1.29e-0446443GO:0051693
GeneOntologyBiologicalProcessnegative regulation of actin filament depolymerization

TRIOBP VILL ADD1

1.86e-0452443GO:0030835
GeneOntologyBiologicalProcessaxial mesoderm development

ZIC2 ZIC3

2.42e-0411442GO:0048318
GeneOntologyBiologicalProcesspeptidyl-lysine trimethylation

FAM86B1 FAM86B2

2.42e-0411442GO:0018023
GeneOntologyBiologicalProcessprotein depolymerization

TRIOBP VILL ADD1 KIF19

2.49e-04144444GO:0051261
GeneOntologyBiologicalProcessregulation of actin filament depolymerization

TRIOBP VILL ADD1

2.99e-0461443GO:0030834
GeneOntologyBiologicalProcessregulation of actin filament polymerization

TRIOBP MYO1C VILL ADD1

3.38e-04156444GO:0030833
GeneOntologyBiologicalProcessprotein methylation

FAM86B1 PRMT8 FAM86B2

3.77e-0466443GO:0006479
GeneOntologyBiologicalProcessactin filament depolymerization

TRIOBP VILL ADD1

3.77e-0466443GO:0030042
GeneOntologyBiologicalProcessprotein alkylation

FAM86B1 PRMT8 FAM86B2

3.77e-0466443GO:0008213
GeneOntologyBiologicalProcessneural plate development

ZIC2 ZIC3

3.98e-0414442GO:0001840
GeneOntologyBiologicalProcessregulation of actin polymerization or depolymerization

TRIOBP MYO1C VILL ADD1

5.44e-04177444GO:0008064
GeneOntologyBiologicalProcessnegative regulation of actin filament polymerization

TRIOBP VILL ADD1

5.49e-0475443GO:0030837
GeneOntologyBiologicalProcessregulation of actin filament length

TRIOBP MYO1C VILL ADD1

5.80e-04180444GO:0030832
GeneOntologyBiologicalProcessactin filament polymerization

TRIOBP MYO1C VILL ADD1

7.10e-04190444GO:0030041
DomainFAM86

FAM86B1 FAM86B2

3.24e-054442PF14904
DomainFAM86

FAM86B1 FAM86B2

3.24e-054442IPR029426
DomainMethyltransf_16

FAM86B1 FAM86B2

2.94e-0411442IPR019410
DomainMethyltransf_16

FAM86B1 FAM86B2

2.94e-0411442PF10294
DomainEPHD

KDM4A KMT2B

1.22e-0322442PS51805
Domain-

FAM86B1 PRMT8 FAM86B2

2.83e-031204433.40.50.150
DomainSAM-dependent_MTases

FAM86B1 PRMT8 FAM86B2

2.96e-03122443IPR029063
DomainPH_dom-like

OBSCN TYK2 TRIOBP PTPN14 RASA2

3.15e-03426445IPR011993
DomainPTPc

PTPN14 PTPRE

3.25e-0336442SM00194
DomainTYR_PHOSPHATASE_PTP

PTPN14 PTPRE

3.80e-0339442PS50055
DomainPTPase_domain

PTPN14 PTPRE

4.20e-0341442IPR000242
DomainY_phosphatase

PTPN14 PTPRE

4.20e-0341442PF00102
DomainFERM_central

TYK2 PTPN14

5.95e-0349442IPR019748
DomainFERM_domain

TYK2 PTPN14

5.95e-0349442IPR000299
DomainFERM_1

TYK2 PTPN14

6.18e-0350442PS00660
DomainFERM_2

TYK2 PTPN14

6.18e-0350442PS00661
DomainFERM_3

TYK2 PTPN14

6.18e-0350442PS50057
DomainBand_41_domain

TYK2 PTPN14

6.18e-0350442IPR019749
DomainB41

TYK2 PTPN14

6.18e-0350442SM00295
DomainSushi

SELE CR2

6.67e-0352442PF00084
DomainCCP

SELE CR2

7.18e-0354442SM00032
Domain-

UBA6 CRYL1 CRYZ

7.34e-031694433.40.50.720
DomainSUSHI

SELE CR2

7.71e-0356442PS50923
DomainNAD(P)-bd_dom

UBA6 CRYL1 CRYZ

7.83e-03173443IPR016040
DomainSushi_SCR_CCP_dom

SELE CR2

7.97e-0357442IPR000436
DomainPTPc_motif

PTPN14 PTPRE

8.52e-0359442SM00404
DomainTyr_Pase_cat

PTPN14 PTPRE

8.52e-0359442IPR003595
Pubmed

Lack of association between ZIC2 and ZIC3 genes and the risk of neural tube defects (NTDs) in Hispanic populations.

ZIC2 ZIC3

1.64e-06245212522805
Pubmed

ZIC2 and ZIC3 promote SWI/SNF recruitment to safeguard progression towards human primed pluripotency.

ZIC2 ZIC3

1.64e-06245239358345
Pubmed

The role of Zic family zinc finger transcription factors in the proliferation and differentiation of retinal progenitor cells.

ZIC2 ZIC3

4.91e-06345222024047
Pubmed

Genetic variants in ZIC1, ZIC2, and ZIC3 are not major risk factors for neural tube defects in humans.

ZIC2 ZIC3

4.91e-06345214679585
Pubmed

Overlapping and distinct expression domains of Zic2 and Zic3 during mouse gastrulation.

ZIC2 ZIC3

4.91e-06345215261827
Pubmed

The mouse zic gene family. Homologues of the Drosophila pair-rule gene odd-paired.

ZIC2 ZIC3

4.91e-0634528557628
Pubmed

Zic4, a zinc-finger transcription factor, is expressed in the developing mouse nervous system.

ZIC2 ZIC3

9.81e-06445215895369
Pubmed

SUMOylation Potentiates ZIC Protein Activity to Influence Murine Neural Crest Cell Specification.

ZIC2 ZIC3

9.81e-06445234638777
Pubmed

An Evolutionarily Conserved Mesodermal Enhancer in Vertebrate Zic3.

ZIC2 ZIC3

9.81e-06445230297839
Pubmed

Molecular properties of Zic proteins as transcriptional regulators and their relationship to GLI proteins.

ZIC2 ZIC3

9.81e-06445211053430
Pubmed

A novel zinc finger protein, zic, is involved in neurogenesis, especially in the cell lineage of cerebellar granule cells.

ZIC2 ZIC3

9.81e-0644527931345
Pubmed

Myogenic repressor I-mfa interferes with the function of Zic family proteins.

ZIC2 ZIC3

1.63e-05545215207726
Pubmed

FAM86A methylation of eEF2 links mRNA translation elongation to tumorigenesis.

FAM86B1 FAM86B2

1.63e-05545238508183
Pubmed

HIV-protein-mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium.

SELE LAMA3

2.45e-0564529597096
Pubmed

Physical and functional interactions between Zic and Gli proteins.

ZIC2 ZIC3

2.45e-05645211238441
Pubmed

Zic2 patterns binocular vision by specifying the uncrossed retinal projection.

ZIC2 ZIC3

3.42e-05745213678579
Pubmed

Mesp1 controls the chromatin and enhancer landscapes essential for spatiotemporal patterning of early cardiovascular progenitors.

ZIC2 ZIC3

3.42e-05745235817961
Pubmed

The expression of the mouse Zic1, Zic2, and Zic3 gene suggests an essential role for Zic genes in body pattern formation.

ZIC2 ZIC3

4.56e-0584529070329
Pubmed

The mutant leucine-zipper domain impairs both dimerization and suppressive function of Foxp3 in T cells.

ITGAE IL5

4.56e-05845216769892
Pubmed

The LFA-1 adhesion molecule is required for protective immunity during pulmonary Mycobacterium tuberculosis infection.

SELE ITGAE

4.56e-05845216585587
Pubmed

Spatiotemporal expression of Zic genes during vertebrate inner ear development.

ZIC2 ZIC3

7.32e-051045223606270
Pubmed

Mouse Zic5 deficiency results in neural tube defects and hypoplasia of cephalic neural crest derivatives.

ZIC2 ZIC3

7.32e-051045215136147
Pubmed

CD spectra show the relational style between Zic-, Gli-, Glis-zinc finger protein and DNA.

ZIC2 ZIC3

7.32e-051045218298960
Pubmed

A role for Zic1 and Zic2 in Myf5 regulation and somite myogenesis.

ZIC2 ZIC3

7.32e-051045221211521
Pubmed

Fibroblast growth factor 8 organizes the neocortical area map and regulates sensory map topography.

ZIC2 ZIC3

8.94e-051145222623663
Pubmed

Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects.

LSS ACACA CR2

9.15e-056745316806233
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

OBSCN TYK2 UBA6 LAMA3 TRIOBP LSS ACACA PTPRE RASA2

1.04e-04148945928611215
Pubmed

Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.

OBSCN TYK2 MYOF LSS CRYZ BPHL MYO1C

1.10e-0485945731536960
Pubmed

Several genes contribute to the production of autoreactive B and T cells in the murine lupus susceptibility locus Sle1c.

PTPN14 CR2

1.27e-041345216002709
Pubmed

New semidominant mutations that affect mouse development.

ZIC2 ZIC3

1.94e-041645215384171
Pubmed

Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.

SELE ADD1

1.94e-041645210391210
Pubmed

Protein tyrosine phosphatases expression during development of mouse superior colliculus.

PTPN14 PTPRE

2.20e-041745219727691
Pubmed

Zic2 and Zic3 synergistically control neurulation and segmentation of paraxial mesoderm in mouse embryo.

ZIC2 ZIC3

2.47e-041845217490632
Pubmed

Multiple genetic variants along candidate pathways influence plasma high-density lipoprotein cholesterol concentrations.

LSS ACACA SOAT2 ADD1

3.08e-0425045418660489
Pubmed

Age of onset of amyotrophic lateral sclerosis is modulated by a locus on 1p34.1.

LAMA3 KDM4A

3.38e-042145222959728
Pubmed

Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.

KDM4A KMT2B

3.38e-042145227626377
Pubmed

Zic deficiency in the cortical marginal zone and meninges results in cortical lamination defects resembling those in type II lissencephaly.

ZIC2 ZIC3

3.72e-042245218448648
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

OBSCN UBA6 KDM4A ACACA KIF19

4.45e-0449745536774506
Pubmed

Zic1 and Zic3 regulate medial forebrain development through expansion of neuronal progenitors.

ZIC2 ZIC3

4.82e-042545217507568
Pubmed

Transcriptional regulatory networks in epiblast cells and during anterior neural plate development as modeled in epiblast stem cells.

ZIC2 ZIC3

5.22e-042645222992956
Pubmed

Deubiquitinating Enzyme USP9X Suppresses Tumor Growth via LATS Kinase and Core Components of the Hippo Pathway.

PTPN14 MYO1C

5.22e-042645228720576
Pubmed

The mouse mahoganoid coat color mutation disrupts a novel C3HC4 RING domain protein.

FAM86B1 FAM86B2

6.50e-042945212438443
Pubmed

The genomic basis of cerebral palsy: a HuGE systematic literature review.

SELE ADD1

8.94e-043445219238444
Pubmed

A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.

KMT2B FIZ1 ZIC3

9.04e-0414645323892456
Pubmed

New application of intelligent agents in sporadic amyotrophic lateral sclerosis identifies unexpected specific genetic background.

SELE ADD1

9.48e-043545218513389
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

TYK2 PTPN14

3.10e-03503021293
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

SELE CR2

4.01e-03573021179
GeneFamilyZinc fingers C2H2-type|ZF class homeoboxes and pseudogenes

ZNF264 ZNF630 ZIC2 FIZ1 ZIC3

6.08e-0371830528
CoexpressionGSE22501_PERIPHERAL_BLOOD_VS_CORD_BLOOD_TREG_UP

LAMA3 TRIOBP PTPN14 BPHL ACACA SMOX IL5

4.49e-08198457M8370
CoexpressionAtlasPluripotent Stem Cells-reprogram_NA_vs_Pluripotent Stem Cells-reprogram_OSK-L-l-p53KD-Confounder_removed-fold2.0_adjp0.05

FAM86B1 FAM86B2

1.20e-053432PCBC_ratio_ESC_vs_iPSC_method-OSK-L-l-p53KD_cfr-2X-p05
ToppCellfacs-Brain_Non-Myeloid-Cortex_-18m-Epithelial-neuronal_stem_cell|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CRYL1 PTPN14 PTPRE CR2 KIF19

6.57e-071644550853e75b60b2a78257b660910c3ee15b09c5f5b0
ToppCelldroplet-Heart-nan-3m-Endothelial-nan|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

UBA6 AASDH RASA2 CR2

1.90e-05157454d85a2f56ae313baa9738e81d2756ce1fe1ba50db
ToppCellPND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ADAMTSL1 PTPN14 PTPRE ZIC2

2.26e-051644547a8e5ef52a8fd2877d59ef0696af8a7af90bbed6
ToppCellPND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ADAMTSL1 PTPN14 PTPRE ZIC2

2.26e-051644545e5bd81414ea2d64f73cdef19a0a78c17bec8c18
ToppCellPND10-Endothelial-Endothelial_lymphatic|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ADAMTSL1 PTPN14 PTPRE ZIC2

2.26e-05164454f13b8d9b7f42193f333d9a77571a1dde6bbb48d8
ToppCellPND10-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ADAMTSL1 PTPN14 PTPRE ZIC2

2.26e-051644544cfc9f92e49f86d3639e018b35b6a60dc62f494a
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

PTPN14 FAM86B2 ACACA PTPRE

2.60e-05170454a2c738e441ced90eeeb1fcc6ca3269b918aaa298
ToppCellfacs-Lung-nan-3m-Endothelial-Artery_endothelial_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SELE LAMA3 MYOF PTPN14

3.46e-0518345412e876d6205af8aad74265c668b5e95b9e7487f3
ToppCellwk_20-22-Endothelial-Lymph_endothelial-SCG3+_lymphatic_endothelial|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

PTPN14 PTPRE ZIC2 ZIC3

3.77e-0518745455aad84b992412e487a32f4970620189a7380ba6
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

LAMA3 MYOF ADAMTSL1 PTPN14

3.85e-05188454eea652bab161f19148a883e7e3fe2523b36b3cea
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar-AT1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

LAMA3 PTPN14 PTPRE MYO1C

4.62e-051974548d5097898dd01cedb04cb694cb480c931e08462c
ToppCellHippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Cbln1|Hippocampus / BrainAtlas - Mouse McCarroll V32

OBSCN LAMA3 VILL

4.88e-05704538d6bdf2e773e894a0db39fdff1fafc2474e03fcf
ToppCellSepsis-ICU-NoSEP-Myeloid-cDC2|ICU-NoSEP / Disease, condition lineage and cell class

TYK2 LRRK1 CLNK SMOX

4.89e-0520045459cb0b0dee2599b3d3014b66d71d84c22b5de4b2
Diseasecranial vault morphology measurement

LAMA3 ADAMTSL1 BBS9

6.87e-04121423EFO_0009278
DiseaseIgA glomerulonephritis (is_implicated_in)

SELE ADD1

8.39e-0430422DOID:2986 (is_implicated_in)
DiseaseEczema, Infantile

SELE IL5

1.21e-0336422C0086196
DiseaseDermatitis, Atopic

SELE IL5

1.21e-0336422C0011615
Diseasecups of coffee per day measurement

EDC3 ADD1

1.49e-0340422EFO_0006782
Diseasetotal hip arthroplasty, osteoarthritis

TRIOBP SMOX

1.64e-0342422EFO_0009806, MONDO_0005178
Diseaseleft ventricular systolic function measurement

OBSCN MYO1C

1.80e-0344422EFO_0008206
Diseaserheumatoid arthritis, anti-citrullinated protein antibody seropositivity, rheumatoid factor seropositivity measurement

TYK2 KMT2B CLNK

1.83e-03170423EFO_0000685, EFO_0007791, EFO_0007837
DiseaseMultiple Sclerosis

TYK2 SELE

1.88e-0345422C0026769
DiseaseMultiple Sclerosis, Acute Fulminating

TYK2 SELE

1.88e-0345422C0751324
DiseaseNonsyndromic Hearing Loss and Deafness, Autosomal Recessive

TRIOBP GRXCR1

2.41e-0351422cv:CN043650
Diseaseidiopathic osteonecrosis of the femoral head

CLNK KIAA1614

2.51e-0352422EFO_1001930

Protein segments in the cluster

PeptideGeneStartEntry
FVHCDPHPGNVLVRK

ADCK1

311

Q86TW2
AHVPCPRGHVIAARI

ACACA

496

Q13085
PHKCIVPNIQHFRVL

AASDH

211

Q4L235
PVVPAKPVQCVHHVS

PRMT8

36

Q9NR22
CPLVVKITLHVPEHL

ASTN1

406

O14525
QQLVVHIKACHGLPL

RASA2

171

Q15283
HQVLIKVHACGVNPV

CRYZ

36

Q08257
KTLNPVHAGPIVVHC

PTPRE

321

P23469
LQKTVRHPVCVKHPP

FAM86B2

51

P0C5J1
GCLRNIHVNHIPVPV

LAMA3

3301

Q16787
ILTKIERVQHPHECP

GRXCR1

226

A8MXD5
HPCIVALIGISIHPL

LRRK1

1316

Q38SD2
HCNKIIHIPSPRTGR

KIAA1614

226

Q5VZ46
PCIGPHLAVQHRQVF

ADAMTSL1

1621

Q8N6G6
EILCHPVEHVPIPKG

ITGAE

76

P38570
HHGVLICIQVLVRRP

ITGAE

101

P38570
LQKTVRHPVCVKHPP

FAM86B1

51

Q8N7N1
LLQEKCPHVTEHIPR

LSS

466

P48449
SKLPRHHPLVLQECV

KDM4A

601

O75164
DAVHQPPKGLVRCAH

SELE

431

P16581
SPVQGPRIKHVCRHA

KMT2B

861

Q9UMN6
VHQRPTVALLCGPHV

EDC3

331

Q96F86
LPHIPVAVRVGCLHD

BBS9

326

Q3SYG4
VCRHPAPGIRHLGKV

KIF19

926

Q2TAC6
CPHVPIAVAGQKAVI

OBSCN

5726

Q5VST9
RIPVPVHKNHQLCTE

IL5

51

P05113
VIHCHPPPVIVNGKH

CR2

716

P20023
RHVLVHTGEKPFPCL

FIZ1

431

Q96SL8
VHVKQCIVAHPVNPP

CRYL1

136

Q9Y2S2
RHLLPRVQCPALIVH

BPHL

226

Q86WA6
HIPFPQTKPHIARCV

HEXA-AS1

36

Q9H8Q6
KNRHPPIVVHCSAGV

PTPN14

1111

Q15678
LHGSPVLIPQVCIGH

TRIOBP

1206

Q9H2D6
LCALPVHVAVEHQLP

SOAT2

211

O75908
RPDVKCVVHIHTPAG

ADD1

231

P35611
TGVHRKQCHLTQPLP

CLNK

406

Q7Z7G1
PGIVTCLENHPHKLE

UBA6

226

A0AVT1
VNHIRVHTGEKPFPC

ZIC3

316

O60481
PAHVIQLGKPVRCIH

SMOX

251

Q9NWM0
KEIPHIVVTHCLLNP

ZBED8

261

Q8IZ13
LHRQPVDPKRHGQLC

VILL

401

O15195
CGKSPLIIHQKTHPR

ZNF630

581

Q2M218
PVPKAELICHLEHGQ

ZNF264

56

O43296
VNHIRVHTGEKPFPC

ZIC2

321

O95409
VCIHIAHKVGITPPC

TYK2

56

P29597
GEIIRVVHPHRPCKL

MYO1C

11

O00159
IRPVVKVHVCGQTHR

MYOF

216

Q9NZM1