Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionnucleoside-triphosphatase regulator activity

RANGAP1 RASGRF2 PCP2 SIRPG FBXO8 TIAM1 ARHGAP31 ARHGAP12 DEPDC5 VAV3 RIMS1 RPGR ARHGAP18 SIPA1L2

7.38e-0550716314GO:0060589
GeneOntologyMolecularFunctionGTPase regulator activity

RANGAP1 RASGRF2 PCP2 SIRPG FBXO8 TIAM1 ARHGAP31 ARHGAP12 DEPDC5 VAV3 RIMS1 RPGR ARHGAP18 SIPA1L2

7.38e-0550716314GO:0030695
GeneOntologyMolecularFunctionSH3 domain binding

PICALM SIRPG ZNF106 SYNJ2 ARHGAP31 SKAP1 RIMS1

1.75e-041431637GO:0017124
GeneOntologyBiologicalProcessregulation of small GTPase mediated signal transduction

RASGRF2 PICALM CYRIB RASIP1 FBXO8 TIAM1 ARHGAP31 ARHGAP12 NGF VAV3 ARHGAP18 SIPA1L2

1.25e-0533316112GO:0051056
GeneOntologyCellularComponentcell cortex

RIMS3 SPTBN1 PPFIA3 SHROOM2 WDPCP AXIN1 PARD6B MACF1 RIMS1 SEPTIN7 SNX9 ENO2

3.81e-0537116412GO:0005938
GeneOntologyCellularComponentpericentriolar material

CEP192 BBS9 TIAM1 CDK5RAP2

6.46e-05281644GO:0000242
GeneOntologyCellularComponentcell projection membrane

SPTBN1 ADGRV1 ACE BBS9 CDKL5 TIAM1 SYNJ2 PROM2 CD36 CSPG4 MACF1 SLC7A5

1.58e-0443116412GO:0031253
GeneOntologyCellularComponentcell leading edge

SPTBN1 ADGRV1 CDKL5 LDB1 TIAM1 SYNJ2 ARHGAP31 CSPG4 UNC5C MACF1 PRKCI ARHGAP18 SNX9

1.65e-0450016413GO:0031252
Domain-

FAT4 FAT3 ADGRV1 CRP THBS2 THBS4 CSPG4

2.13e-059516572.60.120.200
DomainEGF_CA

FAT4 FAT3 THBS2 THBS4 NID1 C1S

1.14e-04861656PF07645
DomainLaminin_G

FAT4 FAT3 THBS2 THBS4 CSPG4

1.59e-04581655IPR001791
DomainPrepro-melanin_conc_hormone

PMCHL1 PMCHL2

2.31e-0431652IPR005456
DomainPro-MCH

PMCHL1 PMCHL2

2.31e-0431652PF05824
DomainEGF_3

FAT4 FAT3 THBS2 THBS4 NID1 C1S ASTN1 HYAL2 OTOG

2.48e-042351659PS50026
DomainEGF-like_dom

FAT4 FAT3 THBS2 THBS4 NID1 C1S ASTN1 HYAL2 OTOG

3.79e-042491659IPR000742
DomainLRRC37AB_C

LRRC37A2 LRRC37A

4.60e-0441652IPR029423
DomainLRRC37AB_C

LRRC37A2 LRRC37A

4.60e-0441652PF14914
DomainLRRC37_N

LRRC37A2 LRRC37A

4.60e-0441652IPR032754
DomainLRRC37

LRRC37A2 LRRC37A

4.60e-0441652PF15779
DomainLRRC37A/B-like

LRRC37A2 LRRC37A

4.60e-0441652IPR015753
DomainConA-like_dom

FAT4 FAT3 ADGRV1 MAMDC4 CRP THBS2 THBS4 CSPG4

7.47e-042191658IPR013320
DomainEGF_CA

FAT4 FAT3 THBS2 THBS4 NID1 C1S

7.54e-041221656SM00179
DomainAWS

NSD1 NSD3

7.62e-0451652SM00570
DomainTSP_3

THBS2 THBS4

7.62e-0451652PF02412
DomainAWS

NSD1 NSD3

7.62e-0451652PS51215
DomainTSP3

THBS2 THBS4

7.62e-0451652PS51234
DomainAWS_dom

NSD1 NSD3

7.62e-0451652IPR006560
DomainTSP_CTER

THBS2 THBS4

7.62e-0451652PS51236
DomainThrombospondin_3_rpt

THBS2 THBS4

7.62e-0451652IPR017897
DomainTSP_type-3_rpt

THBS2 THBS4

7.62e-0451652IPR028974
Domain-

THBS2 THBS4

7.62e-04516524.10.1080.10
DomainThrombospondin_C

THBS2 THBS4

7.62e-0451652IPR008859
DomainTSP_C

THBS2 THBS4

7.62e-0451652PF05735
DomainThrombospondin_3-like_rpt

THBS2 THBS4

7.62e-0451652IPR003367
DomainEGF-like_Ca-bd_dom

FAT4 FAT3 THBS2 THBS4 NID1 C1S

8.21e-041241656IPR001881
DomainSTAT_TF_DNA-bd_sub

STAT5A STAT5B

1.58e-0371652IPR012345
DomainSTAT

STAT5A STAT5B

1.58e-0371652IPR001217
DomainSTAT_int

STAT5A STAT5B

1.58e-0371652SM00964
DomainSTAT_TF_DNA-bd

STAT5A STAT5B

1.58e-0371652IPR013801
DomainSTAT_bind

STAT5A STAT5B

1.58e-0371652PF02864
DomainSTAT_int

STAT5A STAT5B

1.58e-0371652PF02865
Domain-

STAT5A STAT5B

1.58e-03716521.10.532.10
DomainSTAT_alpha

STAT5A STAT5B

1.58e-0371652PF01017
Domain-

STAT5A STAT5B

1.58e-03716521.20.1050.20
DomainSTAT_TF_prot_interaction

STAT5A STAT5B

1.58e-0371652IPR013799
DomainSTAT_TF_coiled-coil

STAT5A STAT5B

1.58e-0371652IPR015988
Domain-

STAT5A STAT5B

1.58e-03716522.60.40.630
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

RANGAP1 GAK SYNM ATP13A1 POLR2B SPTBN1 RCN2 PON2 LRRC40 SCAMP2 CEP192 VARS2 ANKLE2 CACTIN TBC1D31 TIAM1 TRABD ZNF644 VPS13A CDK5RAP2 MACF1 SLC7A5 PRKCI SAMM50 SIPA1L2 ATP2A2

1.38e-0814871682633957083
Pubmed

The human cytoplasmic dynein interactome reveals novel activators of motility.

RANGAP1 KIAA0232 POLR2B RCN2 CEP192 GTPBP1 ACE ANKLE2 ARCN1 PPM1A SPAG5 TBC1D31 SYNJ2 ARHGAP12 SEPTIN7 SIPA1L2 SNX9 CNN2

1.91e-078531681828718761
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

FAT4 SYNM BEND3 APOB CEP192 ARCN1 CDKL5 LIPE ZC3H4 ZBED6 UNC5C VPS13A MKI67 OSBPL9 CDK5RAP2 SLC7A5 RPGR

2.58e-077771681735844135
Pubmed

Angiopoietin 2 induces cell cycle arrest in endothelial cells: a possible mechanism involved in advanced plaque neovascularization.

ANGPT2 STAT5A STAT5B

4.41e-074168314726409
Pubmed

Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.

RANGAP1 POLR2B SPTBN1 RCN2 LMTK2 CEP192 PPFIA3 ANKLE2 PPM1A NSD3 CACTIN TBC1D31 TIAM1 VPS13A MKI67 OTUD4 CDK5RAP2 PRKCI ATP2A2

8.65e-0710491681927880917
Pubmed

Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly.

NES PARD6B MKI67 PRKCI

9.14e-0716168417050694
Pubmed

Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.

POLR2B SPTBN1 NSD1 LMTK2 APOB CEP192 NCSTN TSNAX KLF4 SHROOM2 ANKLE2 SPAG5 TBC1D31 WDHD1 UNC5C OTUD4 CDK5RAP2 MACF1 QSER1

1.40e-0610841681911544199
Pubmed

Requirement of FAT and DCHS protocadherins during hypothalamic-pituitary development.

DCHS2 FAT4 FAT3 MKI67

1.52e-0618168433108146
Pubmed

Fanconi DNA repair pathway is required for survival and long-term maintenance of neural progenitors.

NES FANCA MKI67

2.19e-066168318239686
Pubmed

Fatty acid transport protein 2 reprograms neutrophils in cancer.

STAT5A STAT5B CD36

2.19e-066168330996346
Pubmed

[Population study of the Udmurt population: analysis of ten polymorphic DNA loci of the nuclear genome].

APOB ACE PAH

3.82e-067168317633563
Pubmed

Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila.

DCHS2 FAT4 FAT3

3.82e-067168316059920
Pubmed

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

RANGAP1 SPTBN1 PICALM CDKL5 STXBP6 SYNJ2 PROM2 MACF1 SEPTIN7 ARHGAP18 SNX9 HCFC1 CNN2

4.10e-065651681325468996
Pubmed

Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis.

RANGAP1 GAK ATP13A1 SPTBN1 ANKLE2 ARCN1 VPS13A OSBPL9 SLC7A5 SNX9 HCFC1 CNN2 ALG13

4.34e-065681681337774976
Pubmed

Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.

NES RANGAP1 SPTBN1 NSD1 PPFIA3 PICALM CYRIB SIRPG LDB1 ZC3H4 OTUD4 CDK5RAP2 MACF1 PRKCI RIMS1 QSER1 SEPTIN7

4.74e-069631681728671696
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

NES KIAA0232 NTRK3 SPTBN1 LMTK2 CEP192 NARS2 PPM1A NSD3 ZNF106 TIAM1 SYNJ2 MACF1 PRKCI SIPA1L2 OTOG

4.83e-068611681636931259
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

RANGAP1 ZBTB20 POLR2B NSD1 BEND3 KLF4 GTF3C4 NSD3 FANCA ZSCAN29 ZNF106 CACTIN CDC40 ZNF644 MKI67 SLC7A5 QSER1 ATP2A2 TAF1L HCFC1

4.87e-0612941682030804502
Pubmed

RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.

SYNM ANKLE2 PICALM AXIN1 TBC1D31 MKI67 SECISBP2 MACF1 SIPA1L2

5.86e-06263168934702444
Pubmed

Palmitoylation of BMPR1a regulates neural stem cell fate.

NES CSPG4 MKI67

6.09e-068168331772009
Pubmed

The SPOT technique as a tool for studying protein tyrosine phosphatase substrate specificities.

NTRK3 STAT5A STAT5B

9.10e-069168312237455
Pubmed

Auditory cortex interneuron development requires cadherins operating hair-cell mechanoelectrical transduction.

NES ADGRV1 MKI67

9.10e-069168328705869
Pubmed

Ten years on: mediation of cell death by the common neurotrophin receptor p75(NTR).

RASGRF2 NCSTN TIAM1 NGF VAV3

1.09e-0560168512787561
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

PRUNE2 NRIP1 ZBTB20 KIAA0232 PON2 CEP192 TSNAX ADGRV1 SHROOM2 STAT5B LDB1 SYNJ2 PROM2 OSBPL9 SLC9A7 MACF1 PRKCI SAMM50 RIMS1 QSER1 SNX9

1.12e-0514891682128611215
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

SYNM POLR2B BEND3 LRRC40 VARS2 ANKLE2 NARS2 CDC40 ZC3H4 NUP37 TRABD ZNF644 ARHGAP12 VPS13A OSBPL9 SECISBP2 CDK5RAP2 PRKCI SAMM50 ATP2A2 ALG13

1.20e-0514961682132877691
Pubmed

Cell cycle deregulation and loss of stem cell phenotype in the subventricular zone of TGF-beta adaptor elf-/- mouse brain.

NES RBL2 SPTBN1

1.30e-0510168316884701
Pubmed

Disruption of CK2beta in embryonic neural stem cells compromises proliferation and oligodendrogenesis in the mouse telencephalon.

NES CSPG4 MKI67

1.30e-0510168320368359
Pubmed

G1 arrest and differentiation can occur independently of Rb family function.

NES RBL2 MKI67

1.30e-0510168321059851
Pubmed

Systematic analysis of human protein complexes identifies chromosome segregation proteins.

RANGAP1 RCN2 CEP192 GTF3C4 ARCN1 SPAG5 PARD6B ZNF106 CDC40 SYNJ2 ZC3H4 NUP37 ZNF644 MKI67 CDK5RAP2 PRKCI SAMM50 HCFC1

1.34e-0511551681820360068
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

NES GAK ATP13A1 POLR2B RCN2 GTF3C4 ZNF106 TBC1D31 WDHD1 SYNJ2 SECISBP2 SLC7A5 QSER1 HCFC1

1.43e-057331681434672954
Pubmed

The synaptic vesicle cycle.

RIMS3 PPFIA3 STXBP6 RIMS1

1.49e-0531168415217342
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

RANGAP1 GAK POLR2B NSD1 BEND3 GTF3C4 ARCN1 NSD3 OSBPL9 QSER1 SNX9 HCFC1

1.62e-055491681238280479
Pubmed

Smooth and cardiac muscle-selective knock-out of Kruppel-like factor 4 causes postnatal death and growth retardation.

KLF4 MKI67 ATP2A2

1.78e-0511168320439457
Pubmed

Distinct expression of select and transcriptome-wide isolated 3'UTRs suggests critical roles in development and transition states.

NES KLF4 UNC5C MKI67

1.93e-0533168433951080
Pubmed

Cold-induced protein RBM3 orchestrates neurogenesis via modulating Yap mRNA stability in cold stress.

NES AXIN1 MKI67 NGF

1.93e-0533168430037926
Pubmed

SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.

RANGAP1 SPTBN1 PON2 NCSTN ARCN1 NUP37 ARHGAP12 VPS13A OTUD4 SLC7A5 SAMM50 ATP2A2 ALG13

2.03e-056571681336180527
Pubmed

Increased pro-inflammatory cytokines, C-reactive protein and nerve growth factor expressions in serum of patients with interstitial cystitis/bladder pain syndrome.

CRP NGF

2.32e-052168224146927
Pubmed

Definitive evidence using enucleated cytoplasts for a nongenomic basis for the cystic change in endoplasmic reticulum structure caused by STAT5a/b siRNAs.

STAT5A STAT5B

2.32e-052168223151802
Pubmed

A Mouse Model to Assess STAT3 and STAT5A/B Combined Inhibition in Health and Disease Conditions.

STAT5A STAT5B

2.32e-052168231443474
Pubmed

CD36 binds oxidized low density lipoprotein (LDL) in a mechanism dependent upon fatty acid binding.

APOB CD36

2.32e-052168225555908
Pubmed

Association of common variants in PAH and LAT1 with non-syndromic cleft lip with or without cleft palate (NSCL/P) in the Polish population.

PAH SLC7A5

2.32e-052168224606907
Pubmed

A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK-cell survival and development.

STAT5A STAT5B

2.32e-052168221127177
Pubmed

The gammac-cytokine regulated transcription factor, STAT5, increases HIV-1 production in primary CD4 T cells.

STAT5A STAT5B

2.32e-052168216289657
Pubmed

Deletion of STAT5a/b in vascular smooth muscle abrogates the male bias in hypoxic pulmonary hypertension in mice: implications in the human disease.

STAT5A STAT5B

2.32e-052168225470773
Pubmed

Constitutively active Stat5A and Stat5B promote adipogenesis.

STAT5A STAT5B

2.32e-052168221431790
Pubmed

Krüppel-like factor 4 regulates amyloid-β (Aβ)-induced neuroinflammation in Alzheimer's disease.

ZBTB20 KLF4

2.32e-052168228189744
Pubmed

Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs.

STAT5A STAT5B

2.32e-05216827720707
Pubmed

Amygdala kindling induces nestin expression in the leptomeninges of the neocortex.

NES ENO2

2.32e-052168223305954
Pubmed

ZBTB20 Regulates SERCA2a Activity and Myocardial Contractility Through Phospholamban.

ZBTB20 ATP2A2

2.32e-052168238166470
Pubmed

Stat5: an essential regulator of mast cell biology.

STAT5A STAT5B

2.32e-052168212217382
Pubmed

Brain STAT5 Modulates Long-Term Metabolic and Epigenetic Changes Induced by Pregnancy and Lactation in Female Mice.

STAT5A STAT5B

2.32e-052168231599926
Pubmed

DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites.

STAT5A STAT5B

2.32e-052168210594041
Pubmed

Mitochondrial translocation of signal transducer and activator of transcription 5 (STAT5) in leukemic T cells and cytokine-stimulated cells.

STAT5A STAT5B

2.32e-052168221036145
Pubmed

Stimulation of lipolysis but not of leptin release by growth hormone is abolished in adipose tissue from Stat5a and b knockout mice.

STAT5A STAT5B

2.32e-052168210486277
Pubmed

The role of the STAT5 proteins in the proliferation and apoptosis of the CML and AML cells.

STAT5A STAT5B

2.32e-052168215128421
Pubmed

STAT5 deficiency in hepatocytes reduces diethylnitrosamine-induced liver tumorigenesis in mice.

STAT5A STAT5B

2.32e-052168230377054
Pubmed

Gain-of-function of Stat5 leads to excessive granulopoiesis and lethal extravasation of granulocytes to the lung.

STAT5A STAT5B

2.32e-052168223565285
Pubmed

C-reactive protein-bound enzymatically modified low-density lipoprotein does not transform macrophages into foam cells.

APOB CRP

2.32e-052168218322245
Pubmed

Differentiating the roles of STAT5B and STAT5A in human CD4+ T cells.

STAT5A STAT5B

2.32e-052168223773921
Pubmed

Association between STAT5 polymorphisms and glioblastoma risk in Han Chinese population.

STAT5A STAT5B

2.32e-052168224878107
Pubmed

Cloning and expression of Stat5 and an additional homologue (Stat5b) involved in prolactin signal transduction in mouse mammary tissue.

STAT5A STAT5B

2.32e-05216827568026
Pubmed

Apolipoprotein B and angiotensin-converting enzyme polymorphisms and aerobic interval training: randomized controlled trial in coronary artery disease patients.

APOB ACE

2.32e-052168229846435
Pubmed

STAT5 signaling in sexually dimorphic gene expression and growth patterns.

STAT5A STAT5B

2.32e-052168210486314
Pubmed

Hypoxia-Inducible Factor 2α Attenuates Renal Ischemia-Reperfusion Injury by Suppressing CD36-Mediated Lipid Accumulation in Dendritic Cells in a Mouse Model.

CD36 EPAS1

2.32e-052168236719147
Pubmed

Constitutive activation of STAT5A and STAT5B regulates IgM secretion in Waldenstrom's macroglobulinemia.

STAT5A STAT5B

2.32e-052168224335105
Pubmed

Brain STAT5 signaling modulates learning and memory formation.

STAT5A STAT5B

2.32e-052168229460051
Pubmed

HIF-2α-induced upregulation of CD36 promotes the development of ccRCC.

CD36 EPAS1

2.32e-052168236252650
Pubmed

STAT5 deletion in macrophages alters ductal elongation and branching during mammary gland development.

STAT5A STAT5B

2.32e-052168228606561
Pubmed

Angiopoietin 2 and hsCRP are associated with pulmonary hemodynamics and long-term mortality respectively in CTEPH-Results from a prospective discovery and validation biomarker study.

ANGPT2 CRP

2.32e-052168236609091
Pubmed

Increased cortical expression of two synaptogenic thrombospondins in human brain evolution.

THBS2 THBS4

2.32e-052168217182969
Pubmed

Cell intrinsic defects in cytokine responsiveness of STAT5-deficient hematopoietic stem cells.

STAT5A STAT5B

2.32e-052168212393407
Pubmed

Differential changes in responses of hypothalamic and brainstem neuronal populations to prolactin during lactation in the mouse.

STAT5A STAT5B

2.32e-052168221178171
Pubmed

Stat5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo.

STAT5A STAT5B

2.32e-052168220233708
Pubmed

STAT5 isoforms: controversies and clarifications.

STAT5A STAT5B

2.32e-052168217447893
Pubmed

Duplicated zinc finger protein genes on the proximal short arm of the human X chromosome: isolation, characterization and X-inactivation studies.

ZXDA ZXDB

2.32e-05216828268913
Pubmed

Activation of signal transducer and activator of transcription-5 in prostate cancer predicts early recurrence.

STAT5A STAT5B

2.32e-052168216115927
Pubmed

C-reactive protein levels are inversely correlated with the apolipoprotein B-48-containing triglyceride-rich lipoprotein production rate in insulin resistant men.

APOB CRP

2.32e-052168228183448
Pubmed

Granulocyte-macrophage colony-stimulating factor (GM-CSF)-induced STAT5 activation and target-gene expression during human monocyte/macrophage differentiation.

STAT5A STAT5B

2.32e-052168211867689
Pubmed

Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation.

STAT5A STAT5B

2.32e-052168215340066
Pubmed

Role of Stat5 in type I interferon-signaling and transcriptional regulation.

STAT5A STAT5B

2.32e-052168212901872
Pubmed

Proliferation and multi-differentiation potentials of human mesenchymal stem cells on thermoresponsive PDMS surfaces grafted with PNIPAAm.

NES ENO2

2.32e-052168219445653
Pubmed

Structure and expression of the variant melanin-concentrating hormone genes: only PMCHL1 is transcribed in the developing human brain and encodes a putative protein.

PMCHL1 PMCHL2

2.32e-052168211070051
Pubmed

Serum angiopoietin-2 and CRP levels during COPD exacerbations.

ANGPT2 CRP

2.32e-052168224102428
Pubmed

Identification of isoform-specific dynamics in phosphorylation-dependent STAT5 dimerization by quantitative mass spectrometry and mathematical modeling.

STAT5A STAT5B

2.32e-052168225333863
Pubmed

A role for STAT5 in the pathogenesis of IL-2-induced glucocorticoid resistance.

STAT5A STAT5B

2.32e-052168212421978
Pubmed

Signal transducer and activator of transcription (STAT)-5A and STAT5B differentially regulate human mammary carcinoma cell behavior.

STAT5A STAT5B

2.32e-052168219966185
Pubmed

Signal transducer and activator of transcription 5a/b: biomarker and therapeutic target in prostate and breast cancer.

STAT5A STAT5B

2.32e-052168221704724
Pubmed

Neuron specific enolase and c-reactive protein levels in stroke and its subtypes: correlation with degree of disability.

CRP ENO2

2.32e-052168224838548
Pubmed

Characterization and cloning of STAT5 from IM-9 cells and its activation by growth hormone.

STAT5A STAT5B

2.32e-05216828732682
Pubmed

The neonatal microenvironment programs innate γδ T cells through the transcription factor STAT5.

STAT5A STAT5B

2.32e-052168232281944
Pubmed

Interference of propofol with signal transducer and activator of transcription 5 activation and cardioprotection by remote ischemic preconditioning during coronary artery bypass grafting.

STAT5A STAT5B

2.32e-052168223465551
Pubmed

Prognostic significance of signal transducer and activator of transcription 5 and 5b expression in Epstein-Barr virus-positive patients with chronic lymphocytic leukemia.

STAT5A STAT5B

2.32e-052168227367207
Pubmed

Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation.

STAT5A STAT5B

2.32e-052168216493008
Pubmed

Differential STAT5 signaling by ligand-dependent and constitutively active cytokine receptors.

STAT5A STAT5B

2.32e-052168215677477
Pubmed

A role for STAT5A/B in protection of peripheral T-lymphocytes from postactivation apoptosis: insights from gene expression profiling.

STAT5A STAT5B

2.32e-052168216757175
Pubmed

Identification of a distal STAT5-binding DNA region that may mediate growth hormone regulation of insulin-like growth factor-I gene expression.

STAT5A STAT5B

2.32e-052168215677453
Pubmed

Loss of sexually dimorphic liver gene expression upon hepatocyte-specific deletion of Stat5a-Stat5b locus.

STAT5A STAT5B

2.32e-052168217317776
Pubmed

The Role of STAT5 in Tyrosine Kinase Inhibitor (IMATINIB) Resistance in CML Patients.

STAT5A STAT5B

2.32e-052168232041920
Pubmed

STAT5 requires the N-domain to maintain hematopoietic stem cell repopulating function and appropriate lymphoid-myeloid lineage output.

STAT5A STAT5B

2.32e-052168217976521
Pubmed

Neuronal STAT5 signaling is required for maintaining lactation but not for postpartum maternal behaviors in mice.

STAT5A STAT5B

2.32e-052168225896118
Pubmed

Genome-wide analyses reveal the extent of opportunistic STAT5 binding that does not yield transcriptional activation of neighboring genes.

STAT5A STAT5B

2.32e-052168222319210
InteractionC2CD4B interactions

FAT4 KIAA0232 FAT3 ADGRV1 MACF1 ALPK2

1.40e-06441636int:C2CD4B
InteractionEGLN3 interactions

RANGAP1 POLR2B RCN2 LRRC40 CEP192 ANKLE2 GTF3C4 ARCN1 AXIN1 ZNF106 WDHD1 TRABD ZNF644 OTUD4 SECISBP2 CDK5RAP2 SLC7A5 MTBP SAMM50 SIPA1L2 SNX9 ATP2A2 HCFC1 CNN2 EPAS1 ALG13

1.57e-05129616326int:EGLN3
InteractionNUP210P1 interactions

FAT4 KIAA0232 FAT3 VPS13A RPGR

2.17e-05421635int:NUP210P1
Cytoband5q13

RASGRF2 ADGRV1 THBS4 PMCHL2

1.20e-062216845q13
GeneFamilyCadherin related

DCHS2 FAT4 FAT3

1.33e-0417108324
GeneFamilyRegulating synaptic membrane exocytosis family|PDZ domain containing

RIMS3 RIMS1

2.10e-0441082833
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

RASGRF2 SPTBN1 TIAM1 ARHGAP12 SKAP1 OSBPL9 VAV3

2.37e-042061087682
GeneFamilyPDZ domain containing

SHROOM2 PARD6B TIAM1 CARD11 RIMS1 SIPA1L2

3.02e-0415210861220
GeneFamilyIntermediate filaments Type IV

NES SYNM

5.22e-0461082611
CoexpressionGSE11961_MEMORY_BCELL_DAY40_VS_GERMINAL_CENTER_BCELL_DAY40_DN

ZBTB20 MOGAT2 LMNTD2 SCAMP2 WDPCP GTF3C4 RNF157 TIAM1 SYNJ2 CD36 PRKCI

7.37e-0820016811M9382
CoexpressionFAN_EMBRYONIC_CTX_BRAIN_ENDOTHELIAL_1

NES ANGPT2 SPTBN1 PON2 KLF4 ACE BBS9 RASIP1 NID1 SLC7A5 SAMM50 ARHGAP18 EPAS1 HYAL2

1.03e-0644016814M39039
CoexpressionONDER_CDH1_TARGETS_2_UP

PRUNE2 FAT4 SYNM ITGA10 KLF4 SHROOM2 CDK5RAP2 NID1 RIMS1 ENO2

6.67e-0625716810M13867
CoexpressionSWEET_LUNG_CANCER_KRAS_DN

ZBTB20 SPTBN1 KLF4 ACE RASIP1 TIAM1 MACF1 NID1 SLC7A5 LTB ATP2A2 EPAS1

1.91e-0542216812M7396
CoexpressionHE_LIM_SUN_FETAL_LUNG_C7_FGFBP2_POS_NEURAL_PROGENITOR_CELL

SYNM RIMS3 ARHGAP31 ARHGAP18 EPAS1

2.08e-05521685M45792
CoexpressionGSE17974_CTRL_VS_ACT_IL4_AND_ANTI_IL12_48H_CD4_TCELL_UP

ZBTB20 RASGRF2 SYNM LRRC37A2 LMTK2 KLF4 ZXDB VAV3

3.13e-051891688M4199
CoexpressionSWEET_LUNG_CANCER_KRAS_DN

ZBTB20 SPTBN1 KLF4 ACE RASIP1 TIAM1 MACF1 NID1 SLC7A5 LTB ATP2A2 EPAS1

3.15e-0544416812MM1051
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

NRIP1 ZBTB20 POLR2B ANKLE2 PICALM THBS2 TBC1D31 WDHD1 TIAM1 SYNJ2 ZC3H4 ARHGAP12 VPS13A OTUD4 MACF1 PRKCI RPGR

3.83e-0585616817M4500
CoexpressionGSE17974_CTRL_VS_ACT_IL4_AND_ANTI_IL12_72H_CD4_TCELL_UP

NRIP1 SYNM NSD1 LMTK2 PON2 KLF4 ZXDB VAV3

3.92e-051951688M4201
CoexpressionHAN_SATB1_TARGETS_DN

NES RBL2 ITGA10 SHROOM2 ANKLE2 L3MBTL1 WDHD1 STXBP6 SYNJ2 ASTN1 QSER1

4.41e-0538816811M15491
CoexpressionGSE27859_DC_VS_CD11C_INT_F480_INT_DC_DN

ATP13A1 POLR2B FANCA WDHD1 STXBP6 NUP37 SAMM50 SEPTIN7

4.68e-052001688M8600
CoexpressionURS_ADIPOCYTE_DIFFERENTIATION_UP

COL7A1 ECM2 APOB STAT5B SKAP1

6.64e-05661685M15476
CoexpressionGSE21033_1H_VS_24H_POLYIC_STIM_DC_UP

NRIP1 NTRK3 LMTK2 VARS2 RNF157 ARHGAP31 QSER1

8.36e-051611687M7728
CoexpressionZAK_PBMC_MRKAD5_HIV_1_GAG_POL_NEF_AGE_20_50YO_1DY_DN

LIAS RASGRF2 RBL2 POLR2B SPTBN1 RCN2 BBS9 RNF157 SIRPG TBC1D31 ARHGAP12 SKAP1 VPS13A SLC9A7 MACF1 CARD11 LTB ENO2

9.27e-05101216818M40864
CoexpressionAtlasDevelopingGonad_e18.5_epididymis_emap-13166_k-means-cluster#3_top-relative-expression-ranked_200

ZBTB20 FAT3 SPTBN1 CRP C1S

1.06e-05381645gudmap_developingGonad_e18.5_epididymis_200_k3
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-G|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ANGPT2 SPTBN1 ITGA10 PON2 RASIP1 NID1 SLC7A5 SAMM50 RPGR EPAS1 HYAL2

2.68e-10198168110a4626b51ba8b52acbaf616f0ced850079cd7149
ToppCellcellseq-Endothelial-Endothelial_Vascular-Endothelial_capillary|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NES SPTBN1 ITGA10 PON2 KLF4 ACE RASIP1 STXBP6 CD36 EPAS1 HYAL2

2.83e-10199168115f67ea58512856cbdcef759088a5869720a947a8
ToppCellmedial-Endothelial|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NES SPTBN1 ITGA10 PON2 KLF4 ACE RASIP1 STXBP6 RPGR EPAS1 HYAL2

2.98e-1020016811e889b593c2ae53c42944213ce8672cd886917105
ToppCellmedial-2-Endothelial|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NES SPTBN1 ITGA10 PON2 KLF4 ACE RASIP1 STXBP6 RPGR EPAS1 HYAL2

2.98e-102001681170440db2d8be1e29aeb34ea5e8ac72641b5c056f
ToppCellParenchymal-10x3prime_v2-Endothelial-Endothelia_vascular|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

NES SPTBN1 ITGA10 PON2 KLF4 ACE RASIP1 STXBP6 ARHGAP18 EPAS1 HYAL2

2.98e-10200168116567683f8f534310fecb44a6721909183fdc15ca
ToppCellParenchymal-10x3prime_v2-Endothelial|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

NES SPTBN1 PON2 KLF4 ACE RASIP1 STXBP6 CD36 RPGR EPAS1 HYAL2

2.98e-10200168113b07cf1a4dff2e868f52382681a2030c1248caed
ToppCellControl-Endothelial_cells-Capillary_endothelial_cells|Control / group, cell type (main and fine annotations)

SPTBN1 ITGA10 ACE SHROOM2 RASIP1 STXBP6 ARHGAP31 VAV3 SIPA1L2 EPAS1

1.78e-0918016810b043f9ffb9a4cd427a15bebb86a711c7b08866e8
ToppCellFetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NES ITGA10 KLF4 ACE RASIP1 STXBP6 CSPG4 ARHGAP18 EPAS1 HYAL2

2.57e-091871681097b2463fb37e7196dd2f92553acf8e7bc3ec40dd
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary-CAP2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NES SPTBN1 ITGA10 ACE SHROOM2 RASIP1 STXBP6 ARHGAP31 EPAS1 HYAL2

2.85e-0918916810b6b4da51bc7f2c13a2f940540fdc61027d084835
ToppCellChildren_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

FAT4 SPTBN1 ITGA10 PON2 RASIP1 STXBP6 RIMS1 RPGR EPAS1 HYAL2

3.67e-091941681040842a7160f337bfc191ee15fbda3e3d38a04c57
ToppCellCOVID-19-lung-Capillary_Aerocytes|COVID-19 / Disease (COVID-19 only), tissue and cell type

SPTBN1 ITGA10 PON2 ACE SHROOM2 RASIP1 STXBP6 ARHGAP31 SIPA1L2 EPAS1

4.05e-091961681049cc0a2b9739abad61dff7292ea0b14d28ff35c4
ToppCellCOVID-19-lung-Capillary_1|COVID-19 / Disease (COVID-19 only), tissue and cell type

FAT4 SPTBN1 PON2 SHROOM2 RASIP1 STXBP6 ARHGAP31 RPGR ARHGAP18 EPAS1

4.05e-0919616810ac28e9be288af6f00a841aea4ce4b99aed6b4505
ToppCell(6)_Endothelial-E|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

NES SPTBN1 ITGA10 PON2 ACE RASIP1 STXBP6 CD36 EPAS1 HYAL2

4.46e-0919816810a5e1b321376caf262ea48904d31afd1b8e9d3be2
ToppCellParenchymal-10x3prime_v2-Endothelial-Endothelia_vascular-VE_alveolar_capillary_Car4_aerocyte|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

NES SPTBN1 ITGA10 PON2 KLF4 ACE RASIP1 STXBP6 EPAS1 HYAL2

4.91e-09200168103653002c805c314043e2a7b0c9980dfe952dc53e
ToppCellLPS_IL1RA-Endothelial|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

SPTBN1 KLF4 ACE RASIP1 STXBP6 MACF1 ARHGAP18 SIPA1L2 EPAS1 HYAL2

4.91e-09200168105c092b2ecc081b5d04476c56333c338cd89ab984
ToppCellControl_saline-Endothelial-Endothelial-Alv_Gen_Intermediate|Control_saline / Treatment groups by lineage, cell group, cell type

SPTBN1 KLF4 ACE RASIP1 TIAM1 STXBP6 ARHGAP18 SIPA1L2 EPAS1 HYAL2

4.91e-0920016810041a34080120c9f613373c20dcc366292f558040
ToppCellControl_saline-Endothelial-Endothelial-Gen_Cap|Control_saline / Treatment groups by lineage, cell group, cell type

FAT4 SPTBN1 ACE RASIP1 CD36 MACF1 ARHGAP18 SIPA1L2 EPAS1 HYAL2

4.91e-09200168103b97920e1e6e2f09ddba2a861baa9c00c2970f4c
ToppCellControl_saline-Endothelial-Endothelial-Alv_Cap|Control_saline / Treatment groups by lineage, cell group, cell type

SPTBN1 KLF4 ACE RASIP1 STXBP6 VAV3 ARHGAP18 SIPA1L2 EPAS1 HYAL2

4.91e-0920016810abf4ba5fcb54cdeada0da1a8b956a30aa47679e4
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ANGPT2 SPTBN1 ITGA10 PON2 RASIP1 NID1 SLC7A5 RPGR EPAS1 HYAL2

4.91e-0920016810c239e6f5d23caa9a59b83e9b352b2d6a691dcb28
ToppCellLPS_IL1RA-Endothelial-Endothelial|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

SPTBN1 KLF4 ACE RASIP1 STXBP6 MACF1 ARHGAP18 SIPA1L2 EPAS1 HYAL2

4.91e-092001681072ea9882a8ed26fa1534aeb6ba0d1897dccc20c5
ToppCellLPS_only-Endothelial-Endothelial-Gen_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

FAT4 SPTBN1 ACE RASIP1 CD36 MACF1 ARHGAP18 SIPA1L2 EPAS1 HYAL2

4.91e-0920016810eb94a5111ef0e903ee5be9f7efe571b4e6d5fce1
ToppCellControl_saline-Endothelial-Endothelial|Control_saline / Treatment groups by lineage, cell group, cell type

SPTBN1 KLF4 ACE RASIP1 STXBP6 VAV3 ARHGAP18 SIPA1L2 EPAS1 HYAL2

4.91e-0920016810e77eba6172cabf85b8028638ed35299f2f079cd8
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Gen_Cap|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

FAT4 SPTBN1 ACE RASIP1 CD36 MACF1 ARHGAP18 SIPA1L2 EPAS1 HYAL2

4.91e-0920016810a2b9d1cd291d17abddc3ee2e242121412c864b8b
ToppCellControl_saline-Endothelial|Control_saline / Treatment groups by lineage, cell group, cell type

SPTBN1 KLF4 ACE RASIP1 STXBP6 VAV3 ARHGAP18 SIPA1L2 EPAS1 HYAL2

4.91e-09200168103372c488a39fe812fa94e4f0564594186fea3db5
ToppCellAdult-Mesenchymal-pericyte_cell-D231|Adult / Lineage, Cell type, age group and donor

NES TBX4 ANGPT2 SYNM ADAMTSL3 RASIP1 CSPG4 UNC5C NID1

1.98e-081721689858cee96c1c06160863b4adcd7023c0d678bd50f
ToppCell367C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)|367C / Donor, Lineage, Cell class and subclass (all cells)

NES SPTBN1 ITGA10 PON2 KLF4 ACE STXBP6 EPAS1 HYAL2

2.94e-081801689162cec1734e560c068cd61717e40e18dcf92308c
ToppCell367C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-|367C / Donor, Lineage, Cell class and subclass (all cells)

NES SPTBN1 ITGA10 PON2 KLF4 ACE STXBP6 EPAS1 HYAL2

2.94e-08180168933c86c22ba877358cd8c1e39b5c0b3dc3a45b7dd
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

NES TBX4 SYNM NTRK3 ADAMTSL3 SHROOM2 CSPG4 UNC5C NID1

3.08e-081811689451b87ac95154bb80018b8dd245b4a6389d81411
ToppCellCOVID-19-Heart-Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

ADAMTSL3 THBS4 CD36 CSPG4 UNC5C NGF NID1 ASTN1 RIMS1

3.08e-08181168933cac65ed1ea5e7bd72250495df4f850b143d5aa
ToppCellCOVID-19-Heart-EC_+_Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

NES ANGPT2 RASGRF2 ADAMTSL3 THBS4 CD36 CSPG4 NGF EPAS1

3.23e-081821689e67f3234165199085c793915ebb1f9bbd845e933
ToppCellControl-Endothelial_cells-Endothelial_cells_(general)|Control / group, cell type (main and fine annotations)

SPTBN1 RASIP1 STXBP6 ARHGAP31 CD36 RIMS1 ARHGAP18 EPAS1 HYAL2

4.09e-081871689fb5bcbc8effdbf0e57fcb71aca990a4aa0d65ce8
ToppCellControl-Endothelial-VE_Capillary_A|Control / Disease state, Lineage and Cell class

NES SPTBN1 ITGA10 PON2 SHROOM2 RASIP1 STXBP6 EPAS1 HYAL2

4.09e-08187168954d7588172ac145ff5045ad9771636729ca3f0ca
ToppCellControl-Endothelial-VE_Capillary_A|Endothelial / Disease state, Lineage and Cell class

NES SPTBN1 ITGA10 PON2 ACE STXBP6 SIPA1L2 ENO2 EPAS1

4.28e-08188168988b3415e33db81726dd29c1f50c886e057af50a0
ToppCell343B-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-|343B / Donor, Lineage, Cell class and subclass (all cells)

NES SYNM SPTBN1 ITGA10 ACE RASIP1 STXBP6 EPAS1 HYAL2

4.28e-081881689fe7143c36e4a883745862d3c3147cf751b440e46
ToppCell343B-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)|343B / Donor, Lineage, Cell class and subclass (all cells)

NES SYNM SPTBN1 ITGA10 ACE RASIP1 STXBP6 EPAS1 HYAL2

4.28e-081881689cbf32b675a7cd0c808d5c9c22dfa7fa79fbe2437
ToppCellIPF-Endothelial-VE_Capillary_A|World / Disease state, Lineage and Cell class

NES SYNM SPTBN1 ITGA10 SHROOM2 RASIP1 STXBP6 EPAS1 HYAL2

4.48e-081891689ea3aa3ef38f1d405bb527ae383cd12c551a3dd6f
ToppCellIPF-Endothelial-VE_Capillary_A|IPF / Disease state, Lineage and Cell class

NES SYNM SPTBN1 ITGA10 SHROOM2 RASIP1 STXBP6 EPAS1 HYAL2

4.68e-081901689b4e35cbfe4d43d2cd51f29c3085e4d9b1012e6f0
ToppCellControl-Endothelial-VE_Capillary_B|World / Disease state, Lineage and Cell class

NES FAT4 SPTBN1 ITGA10 PON2 RASIP1 STXBP6 EPAS1 HYAL2

4.90e-081911689c672c8e28d06d555335976b3f8bd2ea6d3b34aae
ToppCellControl-Endothelial-VE_Capillary_B|Control / Disease state, Lineage and Cell class

NES FAT4 SPTBN1 ITGA10 PON2 RASIP1 STXBP6 EPAS1 HYAL2

4.90e-081911689322237793a1278bafb14e63cab688b353e352dcc
ToppCellEndothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)|World / Lineage, Cell type, age group and donor

NES SPTBN1 ITGA10 KLF4 ACE RASIP1 STXBP6 SIPA1L2 EPAS1

5.12e-0819216891e156bab5ecf64627890d2de9b27603d9a01f28d
ToppCellfacs-Lung-18m-Endothelial-capillary_endothelial|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NES SPTBN1 KLF4 ACE RASIP1 ARHGAP31 CD36 EPAS1 HYAL2

5.36e-081931689ee4b31d9c92f8fd0d3ddb5e723b82300fcb459d1
ToppCell(6)_Endothelial-C_(Capillary_Aerocyte_)|World / Lung cell shreds - cell class (v4) and cell subclass (v4)

NES SPTBN1 ITGA10 KLF4 ACE RASIP1 STXBP6 EPAS1 HYAL2

5.36e-081931689f7f2dc6aff02d096a282835094d26d12b3b73e61
ToppCellfacs-Lung-18m-Endothelial-capillary_endothelial-capillary_endothelial_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NES SPTBN1 KLF4 ACE RASIP1 ARHGAP31 CD36 EPAS1 HYAL2

5.36e-0819316897401e276b644b254c692160d0e7417ec28d50aa4
ToppCellnucseq-Endothelial-Endothelial_Vascular-Endothelial_capillary|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NES SPTBN1 ITGA10 SHROOM2 RASIP1 STXBP6 ARHGAP31 EPAS1 HYAL2

5.36e-081931689f582e939e3e08a8a3f71deec78c33715be8faa51
ToppCellControl-Endothelial-Endothelial|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FAT4 KLF4 ACE RASIP1 STXBP6 ARHGAP31 VAV3 ARHGAP18 SIPA1L2

5.36e-081931689aff0649c73c634bc6ff0dc7759b4693a9236bf05
ToppCellControl-Endothelial|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FAT4 KLF4 ACE RASIP1 STXBP6 ARHGAP31 VAV3 ARHGAP18 SIPA1L2

5.36e-081931689c5f9fe03e64c211d4bcd4959e5b32f14841e336a
ToppCelldroplet-Lung-21m-Endothelial-capillary_endothelial|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NES SPTBN1 KLF4 ACE RASIP1 ARHGAP31 CD36 EPAS1 HYAL2

5.60e-0819416890d72cb6183062d48488c73320e48044d070fbcac
ToppCelldroplet-Lung-21m-Endothelial|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NES SPTBN1 KLF4 ACE RASIP1 ARHGAP31 CD36 EPAS1 HYAL2

5.60e-081941689b45aebbc7641df0bf56d0c2e88821f1daf705449
ToppCellChildren_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

FAT4 SPTBN1 ITGA10 RASIP1 STXBP6 CD36 RIMS1 EPAS1 HYAL2

5.60e-08194168968004855b23fe1e31e8452d70effabc78a4a0bd3
ToppCelldroplet-Lung-21m-Endothelial-capillary_endothelial-capillary_endothelial_cell|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NES SPTBN1 KLF4 ACE RASIP1 ARHGAP31 CD36 EPAS1 HYAL2

5.60e-0819416891a637809c0ec97374839c3476527e87eea75ed20
ToppCellEndothelial-A-Donor_07|World / lung cells shred on cell class, cell subclass, sample id

NES ANGPT2 RASIP1 STXBP6 SYNJ2 SLC7A5 RPGR EPAS1 HYAL2

5.85e-081951689c3a0aa34b672c99cb3a2a4e9218412dbd19da3ca
ToppCellnucseq-Endothelial-Endothelial_Vascular|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NES SPTBN1 ITGA10 RASIP1 STXBP6 ARHGAP31 RPGR EPAS1 HYAL2

6.12e-081961689686533fd3fba8e4df96b9dd1307e870e89db4332
ToppCellCOVID-19-lung-Capillary_1|lung / Disease (COVID-19 only), tissue and cell type

FAT4 SPTBN1 PON2 RASIP1 STXBP6 ARHGAP31 RPGR ARHGAP18 EPAS1

6.39e-0819716897e86ff9dafcbaaa7464d61484dd48bfeb7eae6e4
ToppCelltumor_Lung-Endothelial_cells-Tip-like_ECs|tumor_Lung / Location, Cell class and cell subclass

NES SPTBN1 PPFIA3 ACE RASIP1 STXBP6 CD36 EPAS1 HYAL2

6.39e-081971689353b76ca3e2aa4b8f51396e7121c4baa114083a0
ToppCellwk_08-11-Mesenchymal-Myofibro_&_SMC-Pericyte|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

NES ANGPT2 NTRK3 ADAMTSL3 CSPG4 NID1 SEPTIN7 EPAS1 NPAS1

6.67e-08198168972aad5b2dcd8b0bde58828fa4f8129fe6cb6a21d
ToppCellwk_15-18-Mesenchymal-Myofibro_&_SMC-Pericyte|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

NES TBX4 ANGPT2 ADAMTSL3 CSPG4 NID1 SEPTIN7 EPAS1 NPAS1

6.67e-08198168976d46950c11cb4708866db0da54ce00d5c0adab8
ToppCellControl_saline|World / Treatment groups by lineage, cell group, cell type

SPTBN1 ACE TIAM1 STXBP6 MACF1 ARHGAP18 SIPA1L2 EPAS1 HYAL2

6.97e-08199168911c9c1779caceb725ecccf3f23b7d4e6dbd1af64
ToppCell3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NES SPTBN1 ITGA10 ACE RASIP1 STXBP6 CD36 EPAS1 HYAL2

6.97e-08199168982758d0cee9387d002e3f68a6faa324134fb7564
ToppCellmedial-Endothelial-Capillary_Aerocyte|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NES SPTBN1 ITGA10 KLF4 ACE RASIP1 STXBP6 EPAS1 HYAL2

6.97e-08199168984e30c39c2f050aa64af167999824c1cba32ba05
ToppCellmedial-Endothelial-Capillary_Aerocyte-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NES SPTBN1 ITGA10 KLF4 ACE RASIP1 STXBP6 EPAS1 HYAL2

6.97e-081991689f1039d1ab498fc58f0feba545df05833c235db74
ToppCellmedial-2-Endothelial-Capillary_Aerocyte|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NES SPTBN1 ITGA10 KLF4 ACE RASIP1 STXBP6 EPAS1 HYAL2

6.97e-081991689c5048b31649a0b7eddcd481b0458ed96508f5561
ToppCellcellseq-Endothelial-Endothelial_Vascular|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NES SPTBN1 ITGA10 PON2 RASIP1 STXBP6 RPGR EPAS1 HYAL2

6.97e-081991689307d29816a224193aa3d8c4540e128b2ad2e90b9
ToppCellParenchymal-10x3prime_v2-Endothelial-Endothelia_vascular-VE_capillary|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

PON2 KLF4 RASIP1 STXBP6 CD36 RPGR ARHGAP18 EPAS1 HYAL2

6.97e-081991689772b3f60b83e29b958e1e70dadfd9f058ed4cb7c
ToppCellmedial-Endothelial-Capillary|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SPTBN1 PON2 KLF4 RASIP1 STXBP6 CD36 RPGR EPAS1 HYAL2

7.27e-082001689fd4dcdc67db2a5dbdd54bd2ae975c66df904d4d8
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ANGPT2 ITGA10 ACE RASIP1 NID1 SLC7A5 RPGR EPAS1 HYAL2

7.27e-08200168986ec951234015ced7126b016199e5869a0f22478
ToppCelldistal-2-Endothelial-Capillary|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SPTBN1 PON2 KLF4 RASIP1 STXBP6 CD36 RPGR EPAS1 HYAL2

7.27e-0820016898daf09d63c2fda6da6e5b66f96e7449ee8b17029
ToppCellLPS_only-Endothelial-Endothelial-Alv_Gen_Intermediate|LPS_only / Treatment groups by lineage, cell group, cell type

SPTBN1 KLF4 ACE RASIP1 STXBP6 CD36 ARHGAP18 SIPA1L2 EPAS1

7.27e-082001689b1fadb2b5e37e0f51e079d8409c2647eef68dc3b
ToppCellLPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

NES SPTBN1 KLF4 ACE RASIP1 STXBP6 MACF1 SIPA1L2 EPAS1

7.27e-08200168979e51afb57ca38aacebd0298e5e727b55c0cfff9
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Alv_Cap|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

NES SPTBN1 KLF4 ACE RASIP1 STXBP6 ARHGAP18 EPAS1 HYAL2

7.27e-082001689b7533c571eeea0cb3678e1a57d3dc036fa8d0f49
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Alv_Gen_Intermediate|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SPTBN1 KLF4 ACE RASIP1 STXBP6 CD36 ARHGAP18 EPAS1 HYAL2

7.27e-08200168958a7ece7dfdf6c46f2a50cbcb580574dec14c748
ToppCelldistal-2-Endothelial|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SPTBN1 PON2 KLF4 RASIP1 STXBP6 CD36 RPGR EPAS1 HYAL2

7.27e-082001689bc1781cff7a4602057a59ef65cf16c3a9459c628
ToppCellmedial-Endothelial-Capillary_Intermediate_1-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NES SPTBN1 ITGA10 ACE RASIP1 STXBP6 CD36 EPAS1 HYAL2

7.27e-082001689707148e01e961097819a05437a842b7d3bf72b0a
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_general_capillary-EC_general_capillary_L.2.0.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NES SPTBN1 ITGA10 PON2 RASIP1 STXBP6 CD36 EPAS1 HYAL2

7.27e-082001689ec9a18576a3d08ddfceb70d114c4ab861fbb0d08
ToppCellmedial-2-Endothelial-Capillary_Intermediate_1|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NES SPTBN1 ITGA10 ACE RASIP1 STXBP6 CD36 EPAS1 HYAL2

7.27e-082001689a8adf5902540f6bb15b72efbb9c389b59d67e001
ToppCell5'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_general_capillary|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NES SPTBN1 ITGA10 PON2 RASIP1 STXBP6 CD36 EPAS1 HYAL2

7.27e-08200168924e43d3d16d07571f77e0cd5b2e4758c6ff802cb
ToppCellmedial-Endothelial-Capillary_Intermediate_1|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NES SPTBN1 ITGA10 ACE RASIP1 STXBP6 CD36 EPAS1 HYAL2

7.27e-0820016893ef7b7728615710c691aed8977e2582f19692cf9
ToppCellmedial-2-Endothelial-Capillary|2 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SPTBN1 PON2 KLF4 RASIP1 STXBP6 CD36 RPGR EPAS1 HYAL2

7.27e-082001689e4f390dfd4dd25600f0f7a17c5523283a5966e92
ToppCellmedial-Endothelial-Capillary-2|medial / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

SPTBN1 PON2 KLF4 RASIP1 STXBP6 CD36 RPGR EPAS1 HYAL2

7.27e-0820016894291b5453e98e20ec8150a96ccc865a5964bc645
ToppCellControl_saline-Endothelial-Endothelial-Activated_Alv_Cap|Control_saline / Treatment groups by lineage, cell group, cell type

SPTBN1 KLF4 ACE RASIP1 STXBP6 VAV3 ARHGAP18 SIPA1L2 EPAS1

7.27e-082001689be55cef682ba87250dad97689332c8820b3a7420
ToppCell10x_3'_v2v3-Non-neoplastic-Endothelial|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ANGPT2 ITGA10 ACE RASIP1 NID1 SLC7A5 RPGR EPAS1 HYAL2

7.27e-082001689061ba851f941c616ddb462512e826c412881c3ce
ToppCellControl-Endothelial_cells-Inflamed_endothelial_cells|Control / group, cell type (main and fine annotations)

NES RASGRF2 ACE RASIP1 STXBP6 SIPA1L2 EPAS1 HYAL2

1.76e-071601688958256e3d3836160763b82bb48f794087918d935
ToppCell368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)|368C / Donor, Lineage, Cell class and subclass (all cells)

NES DCHS2 PON2 KLF4 ACE STXBP6 EPAS1 HYAL2

2.33e-07166168830a991fc3275b571d53bd0976df4789e5d40b01d
ToppCell368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-|368C / Donor, Lineage, Cell class and subclass (all cells)

NES DCHS2 PON2 KLF4 ACE STXBP6 EPAS1 HYAL2

2.33e-07166168876b4cd32698900797ec009f17e50ea7ae36b85f4
ToppCelldroplet-Heart-nan-3m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZBTB20 ECM2 NSD1 ZNF106 STXBP6 ZBED6 MACF1 VAV3

3.65e-071761688749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCellLPS-IL1RA-Endothelial-Endothelial-Alv_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

NES SPTBN1 KLF4 ACE STXBP6 ARHGAP18 SIPA1L2 EPAS1

4.33e-071801688544fb373a3346186ec60afe2cfcf141bb04a1eed
ToppCellAdult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D175|Adult / Lineage, Cell type, age group and donor

NES SPTBN1 ITGA10 RASIP1 STXBP6 VAV3 SIPA1L2 EPAS1

4.71e-0718216888b4a07ebd7a133a33ef333cfa29d12c4f3d4d9ac
ToppCelldroplet-Marrow-nan-3m-Myeloid|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SPTBN1 NSD1 KLF4 ANKLE2 ZNF106 STXBP6 MACF1 VAV3

5.33e-0718516887adfa929930cfa795cbfbd9f1a0b439e08aa765d
ToppCellControl-Endothelial-VE_Capillary_A|World / Disease state, Lineage and Cell class

NES SPTBN1 ITGA10 PON2 RASIP1 STXBP6 EPAS1 HYAL2

5.33e-071851688a28187c2fd23564314b35759479ff2ca21f61485
ToppCelldroplet-Heart-nan-24m-Endothelial-endothelial_cell_of_coronary_artery|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NES KLF4 BBS9 RASIP1 LIPE ARHGAP31 CD36 ARHGAP18

5.55e-0718616888b316bfed39b91c15d5ae28d9261eb057f113796
ToppCell343B-Endothelial_cells-Endothelial-E-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

LMTK2 PON2 ACE STXBP6 CD36 ARHGAP18 EPAS1 HYAL2

5.55e-071861688dae6a98963c78bf7518ebab8dc02f173c3b0f7f7
ToppCell356C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-|356C / Donor, Lineage, Cell class and subclass (all cells)

NES SYNM SPTBN1 ACE RASIP1 STXBP6 EPAS1 HYAL2

5.55e-071861688f0b78c7ee20279970ea8961bf59acb5262f2dce5
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NES TBX4 SYNM RIMS3 ADAMTSL3 CSPG4 UNC5C NID1

5.55e-071861688888e85a025bd982d36c910db0f5a3385b1ca3b28
ToppCell343B-Endothelial_cells-Endothelial-E|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

LMTK2 PON2 ACE STXBP6 CD36 ARHGAP18 EPAS1 HYAL2

5.55e-071861688080e56113b89138277a2bd2eabddfa6cd1a18b61
ToppCell356C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)|356C / Donor, Lineage, Cell class and subclass (all cells)

NES SYNM SPTBN1 ACE RASIP1 STXBP6 EPAS1 HYAL2

5.55e-0718616882b3c814a7dee8286ea113c63dc3de5daf0257d37
ToppCellControl-Endothelial-Endothelial-Alv_Cap|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KLF4 ACE RASIP1 STXBP6 ARHGAP31 VAV3 ARHGAP18 SIPA1L2

5.78e-071871688ea9d34bcd3bd1f36745846309ede349773de501a
ToppCellAdult-Mesenchymal-pericyte_cell|Adult / Lineage, Cell type, age group and donor

NES COL7A1 TBX4 SYNM ADAMTSL3 CSPG4 UNC5C NID1

5.78e-07187168862759efb660179402fb574ce5701c89a2e17bcfe
ToppCellCOVID-19-Heart-EC_2|Heart / Disease (COVID-19 only), tissue and cell type

FAT4 ANGPT2 RASGRF2 SYNJ2 ARHGAP31 RPGR SIPA1L2 EPAS1

5.78e-07187168840ffc06a3e3251d9b12da390210d3e045af7537a
ToppCelldroplet-Kidney-nan-3m-Endothelial-kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NES ECM2 LIX1L KLF4 RASIP1 THBS2 ARHGAP31 EPAS1

6.02e-07188168867c04f446fa4528b13a381622e88eb1f314cc6d5
ToppCellFetal_29-31_weeks-Mesenchymal-pericyte_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NES TBX4 SYNM ADAMTSL3 SHROOM2 CSPG4 NID1 EPAS1

6.02e-071881688ccddc08121caff958a2b6f9e278a018858af6b4d
ToppCellAdult-Endothelial-capillary_endothelial_cell_(Cap1)-D122|Adult / Lineage, Cell type, age group and donor

NES SPTBN1 ITGA10 SHROOM2 RASIP1 STXBP6 EPAS1 HYAL2

6.02e-07188168802a62888e9db29d20133eeca1686d302545a39c9
DrugAC1L9KZG

LIAS ACE SPAG5 CRP LDB1 MKI67

1.59e-06491686CID000447569
DrugMemantine Hydrochloride [41100-52-1]; Down 200; 18.6uM; MCF7; HT_HG-U133A

RIMS3 ZNF230 CYRIB STAT5B PARD6B CACTIN STXBP6 SYNJ2 CD36 HCFC1

2.15e-06197168104135_DN
DrugAltretamine [654-05-6]; Down 200; 19uM; MCF7; HT_HG-U133A

NES SPTBN1 PPFIA3 AXIN1 NSD3 STAT5B VPS13A STAG3 EPAS1 HYAL2

2.25e-06198168105688_DN
DrugFamotidine [76824-35-6]; Down 200; 11.8uM; PC3; HT_HG-U133A

ZBTB20 RIMS3 NSD1 KLF4 SHROOM2 BBS9 AXIN1 LDB1 C1S CNN2

2.36e-06199168106665_DN
DrugTerbutaline hemisulfate [23031-32-5]; Up 200; 7.2uM; MCF7; HT_HG-U133A

PRUNE2 RIMS3 SPTBN1 SLC11A1 L3MBTL1 NID1 DEPDC5 RPGR QSER1 HCFC1

2.36e-06199168106240_UP
DrugQuinic acid [86-68-0]; Up 200; 19.6uM; HL60; HT_HG-U133A

DCHS2 SYNM SPTBN1 STAT5B FANCA WDHD1 KCNJ5 CSPG4 ATP2A2 HYAL2

2.36e-06199168102978_UP
Drugglycidol

FAT4 TBX4 PCDHGB7 RIMS3 ITGA10 KLF4 LIPE SLC11A1 TIAM1 ARHGAP31 PAH NGF VAV3 OTOG

9.92e-0646616814ctd:C004312
DrugOxpl

PON2 APOB KLF4 CD36

1.02e-05191684CID000194296
Drug(+,-)-Octopamine hydrochloride [770-05-8]; Down 200; 21uM; MCF7; HT_HG-U133A

RANGAP1 SYNM SPTBN1 GTPBP1 KLF4 AXIN1 PARD6B TRABD MACF1

1.70e-0519816895469_DN
DrugCloperastine hydrochloride [14984-68-0]; Down 200; 11uM; MCF7; HT_HG-U133A

SPTBN1 ANKLE2 BBS9 PARD6B LDB1 SYNJ2 VPS13A ENO2 HCFC1

1.77e-0519916893608_DN
DrugMeclofenoxate hydrochloride [3685-84-5]; Down 200; 13.6uM; HL60; HT_HG-U133A

RANGAP1 ZNF230 PPM1A CACTIN WDHD1 CDC40 SYNJ2 ARHGAP12 ALG13

1.77e-0519916892546_DN
Diseaseinterstitial cystitis (is_marker_for)

CRP MKI67 NGF

1.58e-0651613DOID:13949 (is_marker_for)
Diseasenephrosis (biomarker_via_orthology)

NES ANGPT2 ACE CD36

5.78e-06221614DOID:2527 (biomarker_via_orthology)
Diseaseobesity (biomarker_via_orthology)

PON2 ACE CRP LIPE CD36 PMCHL1 PMCHL2

1.70e-051471617DOID:9970 (biomarker_via_orthology)
Diseasephospholipids:total lipids ratio, intermediate density lipoprotein measurement

MOGAT2 APOB NARS2 ZNF106 MACF1

3.34e-05671615EFO_0008595, EFO_0020946
DiseaseCardiovascular Diseases

PON2 APOB ACE CRP

4.39e-05361614C0007222
DiseaseSotos syndrome 1 (implicated_via_orthology)

NSD1 NSD3

8.84e-0531612DOID:0112103 (implicated_via_orthology)
Diseaseoveractive bladder syndrome (is_marker_for)

CRP NGF

8.84e-0531612DOID:0070355 (is_marker_for)
DiseaseNeurodevelopmental Disorders

CDKL5 ZC3H4 ASXL3 RIMS1 ALG13

1.60e-04931615C1535926
Diseasecholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement

MOGAT2 APOB NARS2 ZNF106 MACF1

2.59e-041031615EFO_0008595, EFO_0020944
Diseasepost-operative atrial fibrillation, response to surgery

ZBTB20 ADGRV1

2.93e-0451612EFO_0009951, EFO_0009952
DiseaseStaphylococcus aureus infection

ACE CD36

2.93e-0451612C1318973
DiseaseStaphylococcal Infections

ACE CD36

2.93e-0451612C0038160
DiseaseCoronary heart disease

APOB ACE CD36

2.97e-04241613C0010068
Diseasechronic myeloid leukemia (is_marker_for)

ACE STAT5A CD36

4.24e-04271613DOID:8552 (is_marker_for)
Diseasepolycythemia (is_implicated_in)

ACE EPAS1

4.37e-0461612DOID:8432 (is_implicated_in)
Diseasegastric adenocarcinoma (is_marker_for)

STAT5A STAT5B SLC7A5

4.72e-04281613DOID:3717 (is_marker_for)
DiseaseAlzheimer disease, family history of Alzheimer’s disease

ACE PICALM STAG3 CNN2 ALPK2

5.03e-041191615EFO_0009268, MONDO_0004975
Diseaseschizophrenia (implicated_via_orthology)

RIMS3 NCSTN ASTN1 RIMS1

5.30e-04681614DOID:5419 (implicated_via_orthology)
Diseasenephrosis (implicated_via_orthology)

ANGPT2 ACE

6.10e-0471612DOID:2527 (implicated_via_orthology)
DiseaseMental Retardation, X-Linked 1

SLC9A7 HCFC1 ALG13

7.04e-04321613C2931498
Diseaseplatelet crit

NRIP1 ZBTB20 ATP13A1 RCN2 APOB ADGRV1 SIRPG STXBP6 TRABD CD36 SKAP1 OTUD4 SLC7A5 CNN2

7.57e-0495216114EFO_0007985
Diseasedisease recurrence, unipolar depression, bipolar disorder, schizophrenia, sex interaction measurement

DCHS2 ACTRT2 CARD11

7.71e-04331613EFO_0003761, EFO_0004952, EFO_0008343, MONDO_0004985, MONDO_0005090
Diseasemicrocephaly (is_implicated_in)

NSD1 CDK5RAP2

8.11e-0481612DOID:10907 (is_implicated_in)
Diseaseprimary ovarian insufficiency (is_implicated_in)

BBS9 FANCA

8.11e-0481612DOID:5426 (is_implicated_in)
Diseasetype 2 diabetes mellitus (is_marker_for)

ANGPT2 APOB CRP LIPE CD36

9.21e-041361615DOID:9352 (is_marker_for)
Diseasepulmonary hypertension (biomarker_via_orthology)

ANGPT2 ATP2A2 EPAS1 HYAL2

9.78e-04801614DOID:6432 (biomarker_via_orthology)
Diseaseurticaria, response to non-steroidal anti-inflammatory, angioedema

RIMS1 EPAS1

1.04e-0391612EFO_0005531, EFO_0005532, EFO_0005533
Diseaseliver cirrhosis (is_marker_for)

ACE AXIN1 CRP CD36

1.07e-03821614DOID:5082 (is_marker_for)
Diseasecortical surface area measurement

DCHS2 FAT3 SPTBN1 BEND3 ACTRT2 ADGRV1 ADAMTSL3 BBS9 PICALM AXIN1 ZNF106 STXBP6 ARHGAP31 ARHGAP12 UNC5C MACF1 QSER1

1.13e-03134516117EFO_0010736
Diseaseobsolete_red blood cell distribution width

NRIP1 KIAA0232 LRRC37A2 SCAMP2 APOB BBS9 PICALM CYRIB AXIN1 NSD3 ZC3H4 ZBED6 CD36 VPS13A SLC7A5 C1S CNN2

1.15e-03134716117EFO_0005192
DiseaseSchizophrenia

NRIP1 NTRK3 RIMS3 ADAMTSL3 ACE CRP UNC5C PAH SEPTIN7 ARHGAP18 ATP2A2 ENO2 NPAS1

1.16e-0388316113C0036341
Diseasecolon cancer (biomarker_via_orthology)

AXIN1 CRP MKI67

1.26e-03391613DOID:219 (biomarker_via_orthology)
Diseasecardiovascular system disease (is_marker_for)

APOB CRP

1.29e-03101612DOID:1287 (is_marker_for)
DiseaseCryptogenic Tonic-Clonic Epilepsy

NES NGF

1.29e-03101612C0751117
DiseaseEpilepsy, Tonic-Clonic, Symptomatic

NES NGF

1.29e-03101612C0751119
DiseaseEpilepsy, Tonic-Clonic, Familial

NES NGF

1.29e-03101612C0751118
Diseasefamilial hypercholesterolemia (is_implicated_in)

PON2 APOB

1.29e-03101612DOID:13810 (is_implicated_in)
DiseaseTonic-Clonic Epilepsy

NES NGF

1.29e-03101612C0014549
DiseasePulmonary arterial hypertension

TBX4 EPAS1

1.29e-03101612C2973725
Diseaseeosinophil count

NRIP1 KIAA0232 SPTBN1 BEND3 ANKLE2 GTF3C4 PPM1A STAT5B STXBP6 TRABD SLC7A5 C1S CARD11 PRKCI LTB VAV3 CNN2 ALPK2

1.32e-03148816118EFO_0004842
Diseasecholelithiasis

LIAS NSD1 SYNJ2 SNX9

1.39e-03881614EFO_0004799
DiseaseCombined immunodeficiency

STAT5A STAT5B CARD11

1.46e-03411613C0494261
Diseasevolumetric bone mineral density

SPTBN1 ADGRV1 AXIN1

1.57e-03421613EFO_0007620
Diseaseobstructive sleep apnea (is_implicated_in)

ACE CRP

1.58e-03111612DOID:0050848 (is_implicated_in)
Diseaseresponse to cisplatin, response to antineoplastic agent

HAO1 VAV3

1.58e-03111612GO_0072718, GO_0097327
Diseasehigh grade glioma (implicated_via_orthology)

MKI67 SLC7A5 PRKCI

1.79e-03441613DOID:3070 (implicated_via_orthology)
Diseasepsoriasis (is_marker_for)

CRP MKI67 EPAS1

1.79e-03441613DOID:8893 (is_marker_for)
Diseasepulmonary fibrosis (implicated_via_orthology)

ACE CD36

1.88e-03121612DOID:3770 (implicated_via_orthology)
DiseaseLiver carcinoma

MOGAT2 ACE RNF157 AXIN1 CRP CSPG4 MKI67 MTBP DEPDC5

1.94e-035071619C2239176
DiseaseCeliac Disease

APOB ACE CD36

2.17e-03471613C0007570
DiseasePrimary Ciliary Dyskinesia

RSPH4A ODAD4 RPGR

2.17e-03471613C4551720
DiseaseLeishmaniasis, Visceral

CRP SLC11A1

2.22e-03131612C0023290
Diseaseintermediate coronary syndrome (is_marker_for)

ACE CRP

2.22e-03131612DOID:8805 (is_marker_for)
DiseaseHyperlipoproteinemia Type IIb

PON2 APOB

2.22e-03131612C1704417
DiseaseDepressed mood

ACE CRP

2.22e-03131612C0344315
Diseasecoronary artery disease (is_implicated_in)

PON2 APOB ACE ARHGAP31

2.23e-031001614DOID:3393 (is_implicated_in)
DiseaseKidney Failure, Chronic

ACE CRP NGF

2.30e-03481613C0022661
DiseaseAlzheimer's Disease

NCSTN ACE PICALM UNC5C

2.31e-031011614C0002395
DiseaseMalignant neoplasm of breast

NRIP1 COL7A1 RASGRF2 LRRC37A2 SHROOM2 MAMDC4 STAT5A LIPE LRRC37A FBXO8 SYNJ2 ZNF644 MKI67 MACF1

2.34e-03107416114C0006142
DiseaseWeight Gain

SPTBN1 ACE CD36 NID1

2.40e-031021614C0043094
Diseaseatrial fibrillation (is_implicated_in)

ACE KCNJ5

2.58e-03141612DOID:0060224 (is_implicated_in)
DiseaseLeukemia, Myelocytic, Acute

NTRK3 NSD1 PICALM FANCA ENO2

2.65e-031731615C0023467
Diseasesitting height ratio

TBX4 NSD1 ADAMTSL3

2.74e-03511613EFO_0007118
DiseaseHypertriglyceridemia

APOB CRP

2.97e-03151612C0020557
Diseaseamenorrhea, response to antineoplastic agent

APOB RIMS1

2.97e-03151612EFO_0010269, GO_0097327
DiseaseEpilepsy

CDKL5 ASXL3 ASTN1 ALG13

3.05e-031091614C0014544
DiseaseCongestive heart failure

NRIP1 ACE CRP ATP2A2

3.15e-031101614C0018802
DiseaseHeart failure

NRIP1 ACE CRP ATP2A2

3.15e-031101614C0018801
DiseaseLeft-Sided Heart Failure

NRIP1 ACE CRP ATP2A2

3.15e-031101614C0023212
DiseaseHeart Failure, Right-Sided

NRIP1 ACE CRP ATP2A2

3.15e-031101614C0235527
DiseaseHeart Decompensation

NRIP1 ACE CRP ATP2A2

3.15e-031101614C1961112
DiseaseMyocardial Failure

NRIP1 ACE CRP ATP2A2

3.15e-031101614C1959583
DiseaseCiliopathies

ADGRV1 BBS9 WDPCP RPGR

3.15e-031101614C4277690
Diseasediabetic retinopathy (is_marker_for)

ACE CRP NGF

3.23e-03541613DOID:8947 (is_marker_for)
DiseaseMetastatic melanoma

CDKL5 PRKCI ALPK2

3.23e-03541613C0278883
DiseaseHyperlipoproteinemia Type IIa

PON2 APOB

3.38e-03161612C0745103
Diseasesarcoidosis (is_implicated_in)

ACE SLC11A1

3.38e-03161612DOID:11335 (is_implicated_in)
Diseasecolorectal mucinous adenocarcinoma

ZBTB20 RASGRF2

3.38e-03161612EFO_0009361
DiseaseT-Cell Lymphoma

STAT5B ASXL3

3.38e-03161612C0079772
DiseaseIdiopathic pulmonary arterial hypertension

TBX4 EPAS1

3.38e-03161612C3203102
Diseasephenylalanine measurement

WDHD1 NUP37 PAH

3.40e-03551613EFO_0005001
DiseaseCarcinoma, Granular Cell

FAT4 ACE STAT5A MKI67

3.81e-031161614C0205644
DiseaseAdenocarcinoma, Tubular

FAT4 ACE STAT5A MKI67

3.81e-031161614C0205645
DiseaseAdenocarcinoma, Oxyphilic

FAT4 ACE STAT5A MKI67

3.81e-031161614C0205642
DiseaseCarcinoma, Cribriform

FAT4 ACE STAT5A MKI67

3.81e-031161614C0205643
DiseaseAdenocarcinoma, Basal Cell

FAT4 ACE STAT5A MKI67

3.81e-031161614C0205641
DiseaseAdenocarcinoma

FAT4 ACE STAT5A MKI67

3.81e-031161614C0001418
DiseaseBardet-Biedl syndrome 1 (disorder)

BBS9 WDPCP

3.81e-03171612C2936862
Diseasealkaline phosphatase measurement

ZBTB20 MOGAT2 ATP13A1 RBL2 SPTBN1 APOB AXIN1 RASIP1 SYNJ2 CD36 MACF1 SNX9 ALPK2

3.87e-03101516113EFO_0004533
Diseasesyndrome (implicated_via_orthology)

NSD1 NSD3

4.27e-03181612DOID:225 (implicated_via_orthology)
Diseasebrain infarction

THBS2 SNX9

4.27e-03181612EFO_0004277
DiseaseBardet-Biedl syndrome

BBS9 WDPCP

4.27e-03181612cv:C0752166
DiseaseHypercholesterolemia, Familial

PON2 APOB

4.27e-03181612C0020445
Diseasecholesterol:total lipids ratio, intermediate density lipoprotein measurement

MOGAT2 APOB ZNF106 MACF1

4.42e-031211614EFO_0008595, EFO_0020943
Diseasechylomicron measurement, very low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio

MOGAT2 APOB ZNF106

4.55e-03611613EFO_0008317, EFO_0008596, EFO_0020946
Diseaseinflammatory bowel disease (is_implicated_in)

CRP SLC11A1

4.76e-03191612DOID:0050589 (is_implicated_in)
DiseaseAcute Myeloid Leukemia, M1

NTRK3 NSD1 PICALM ENO2

4.96e-031251614C0026998
DiseaseAcute Myeloid Leukemia (AML-M2)

NTRK3 NSD1 PICALM ENO2

4.96e-031251614C1879321
Diseasetriglycerides:total lipids ratio, intermediate density lipoprotein measurement

MOGAT2 APOB ZNF106 MACF1

5.25e-031271614EFO_0008595, EFO_0020947
DiseaseMalaria

CRP CD36

5.27e-03201612C0024530

Protein segments in the cluster

PeptideGeneStartEntry
ATAPGFDNILFNADG

MAMDC4

1191

Q6UXC1
TPGDAIISLDFGNQN

EPAS1

406

Q99814
AEGNPTDQAGFSEDR

ANKLE2

141

Q86XL3
GIQAEASANDTFPNA

ALG13

1041

Q9NP73
GQPATAFSQQDLLDG

CSPG4

1181

Q6UVK1
PGNFSADEAGAQLFA

ACE

36

P12821
ALDSPAVIFDNGSGF

ACTRT2

6

Q8TDY3
EGEGFCSNSPLQVDN

ALPK2

1091

Q86TB3
GSSPDFNSQFGLVDI

ATP13A1

1151

Q9HD20
LGFDSEGNVVNKPDS

GTPBP1

216

O00178
VTQVFATDPDEGSNG

FAT4

2891

Q6V0I7
DSDPDGDLAFTSGNI

ADGRV1

1906

Q8WXG9
ISQPGNDFSTKDGDN

ANGPT2

416

O15123
SDNQAFQAPGSPEEG

C1orf216

66

Q8TAB5
SAAGNLDEQTPGECF

LINC00313

11

P59037
GGFAPNILENSEALE

ENO2

211

P09104
AFLNPEGDSGTEAEN

ASTN1

341

O14525
FSEGTDNKGNELPSA

ASXL3

886

Q9C0F0
FQGNGFPDRLASTEQ

CDK5RAP2

686

Q96SN8
ANQDSGPGLSLEEFI

RCN2

161

Q14257
ELDLSDNAFGPDGVQ

RANGAP1

116

P46060
AQIGTADPGDFDQLT

RASIP1

356

Q5U651
EDKDSPFGNGQSNFS

NSD1

26

Q96L73
AAADVNGFKPLSGNE

OTUD4

216

Q01804
AEAGSPDQEGFFNLL

PCP2

16

Q8IVA1
DGLPSDQFAKGQDTV

QSER1

1321

Q2KHR3
LAGGTNFSDTVQADP

NCSTN

501

Q92542
SQAEGGQTPLDAFQL

NPAS1

406

Q99742
IAQVSASDPDFGLNG

PCDHGB7

471

Q9Y5F8
SFESGQNGFIPSNEV

PARD6B

326

Q9BYG5
QGLDSGFVPSVQDFD

OSBPL9

106

Q96SU4
PLNQTDINVGFDTGD

KCNJ5

251

P48544
ENLTGFLEPGNFGES

RBL2

316

Q08999
EDSQPSGQVASFFEA

BEND3

346

Q5T5X7
RLEQAEGFPQGDNST

DEPDC5

286

O75140
LFGGLANDSEDPKNN

HCFC1

151

P51610
DLNAFDVQASPNEGF

HYAL2

56

Q12891
NLADINDVSPSGGFV

KLF4

186

O43474
PELAAGFDGNSIFNF

KIAA0100

771

Q14667
PNISGEFGLDNFDSQ

PRKCI

541

P41743
EFGLDNFDSQFTNEP

PRKCI

546

P41743
GAKPANSAAENGFQE

GPR39

436

O43194
QGAFSSLGDLSPQEN

LRRC37A2

1356

A6NM11
QGAFSSLGDLSPQEN

LRRC37A

1356

A6NMS7
GIDDEDSFNNSPALG

LDB1

371

Q86U70
QDLDFEVGGAAPFNR

NGF

101

P01138
GNLFPLLEGQDSGNS

NTRK3

51

Q16288
FGAELLSPSGQADVQ

PPFIA3

586

O75145
DSRDGGFPNDASTEN

DCAF8L2

56

P0C7V8
PFSFETLNLGNENTD

KIAA0232

661

Q92628
DLGSSNDGCPQLFQE

L3MBTL1

181

Q9Y468
DDLGLPNGLTFDAFS

NID1

1106

P14543
LSFSPEENFGDDSGL

HAO1

191

Q9UJM8
EGSLTFNANPDEGVN

FBXO8

141

Q9NRD0
GNLETFLFPGTENQE

NES

641

P48681
KGDVSNLDPNFSFEG

SLC7A5

221

Q01650
NREEADNPNTGIGAF

LIX1L

201

Q8IVB5
EEDQNFNISGSAFPT

NRIP1

46

P48552
NGPDLQDFVSGDLAD

LIAS

41

O43766
SGPESPFNNIFNDVD

LMTK2

626

Q8IWU2
AFLDPGNIESDLQAG

SLC11A1

71

P49279
SDLSENIQAPTGEGF

LMNTD2

196

Q8IXW0
INNFGDSINESEGIP

MKI67

486

P46013
VVEFNPFENGDSGNL

NUP37

21

Q8NFH4
QFSQEIGLASLGAPD

PAH

301

P00439
SLFPGFASQSDDDQV

BBS9

561

Q3SYG4
NFTQGLVEDAPDGSD

MACF1

5076

Q9UPN3
DASISKGDFQNPGDQ

ARHGAP12

301

Q8IWW6
PAAQQQEGSGFFLSE

DCHS2

91

Q6V1P9
GADSQFSDFLDGLGP

RIMS1

1511

Q86UR5
FGENDLFDQIPNSSG

MOGAT2

226

Q3SYC2
GQNLGSFSPGEFDLI

METTL21A

126

Q8WXB1
AEGFDSANGINISPD

PON2

216

Q15165
NEAFIGLSLAPQGED

WDPCP

651

O95876
SNPDLFGEFLNSDSV

GAK

976

O14976
SPLFTLDANADIGNG

APOB

2766

P04114
AFTGREFDELNPSAQ

ATP2A2

651

P16615
DAEDNTVSFLQPNGA

CD36

106

P16671
QEGRQFASDFLSPEA

FANCA

1201

O15360
QGFPLDLGASFTEDA

AXIN1

6

O15169
SGNSEFFLDPESGEL

FAT3

3071

Q8TDW7
DSGGAFAVQDPNDKT

C1S

631

P09871
EQDSFGGNFEGSQSL

CRP

156

P02741
NQEAFTDNPALGFVD

ASIC5

236

Q9NY37
TGNSIASIPDEAFNG

ECM2

351

O94769
GSVAFPAENGVQDTE

PMCHL1

31

Q16048
GSVAFPAENGVQDTE

PMCHL2

31

Q9BQD1
LPDLNQDGFADVAVG

ITGA10

556

O75578
EPAGATESLQGQDLF

CEP192

131

Q8TEP8
NTDNPFGDNNLLGTF

CACTIN

196

Q8WUQ7
ASTSEGLENFQGEDP

C2orf81

141

A6NN90
QTFFAVDDGPSLDQA

COL7A1

1211

Q02388
TDLEQGPNFFLDFEN

CYRIB

11

Q9NUQ9
ADEGLPANESFLNGN

CDKL5

356

O76039
CQGDDALPNGLDVTF

SAMM50

106

Q9Y512
DFGDASPRTNGQEAD

CARD11

461

Q9BXL7
SGSLEFSIAGQPNDF

ARCN1

451

P48444
DIPEEANQNLSFGAT

LRRC40

61

Q9H9A6
EDNIAFFSSQGPGET

LIPE

316

Q05469
SGEGTENQPDFTAAN

MTBP

31

Q96DY7
NEGAPAVQGTDVEAF

PAGE5

76

Q96GU1
GNSLIVFDDDSGNPS

OTOG

1046

Q6ZRI0
GIADGFQQPEAIEFS

RPGR

726

Q92834
AEGGRNSFEENPDFE

RSPH4A

516

Q5TD94
LQSSEPGDQGLFEAF

VARS2

931

Q5ST30
FAAEPGNNELTVNEG

SNX9

11

Q9Y5X1
LGLQEGSNNSSPVDF

SPAG5

56

Q96R06
NFAGLPAGEQDAEGN

RNF157

576

Q96PX1
FLPDSFDAGSNQVLG

TBC1D31

266

Q96DN5
NFQEGGQLASAAPDL

PRUNE2

2056

Q8WUY3
EGFSGQIQFTAPLSD

SYNM

1271

O15061
FNQPGVSDSELGGDD

SYNJ2

1026

O15056
ESQFSDFLDGLGPAQ

RIMS3

131

Q9UJD0
EGTPNFTEEGLVNFS

RASGRF2

1166

O14827
NDSEGAGELFQLEPS

NARS2

186

Q96I59
AGSDEEGDNPFSAIQ

TAF1L

1776

Q8IZX4
EGDNPFSAIQLSESG

TAF1L

1781

Q8IZX4
DDEAFGEALQSPASG

ODAD4

551

Q96NG3
FKENDASNIDGFLGP

CDC40

181

O60508
PGLLVFAGSSEQDAN

HOATZ

21

Q6PI97
ANKGEIGDATPFNDA

POLR2B

991

P30876
NNETAGPAFEEFLDL

SIPA1L2

626

Q9P2F8
DSLGQEPGAASFQND

SHROOM2

441

Q13796
SGGDDQFPEQAELSG

SECISBP2

566

Q96T21
QGGLAEFNPFSETNA

SCAMP2

31

O15127
QVVPEFVNASADAGG

STAT5B

706

P51692
SDLAFGGSQQSPEVA

PROB1

571

E7EW31
GNELSDFQTNVDPTG

SIRPG

186

Q9P1W8
SQDNFGFDLPAVEAA

SPTBN1

446

Q01082
QVVPEFVNASADAGG

STAT5A

701

P42229
NPVDLFEANDLFESG

CNN2

101

Q99439
PSAGLNVDFESVFGN

PICALM

481

Q13492
GNPEAAGNSGFQLLD

SLC7A6OS

126

Q96CW6
QQSEPLAATGTGDFN

THBS4

206

P35443
VHPDSDFFGQEGETQ

ZXDB

761

P98169
RQVNGIDPNGDSAEF

STXBP6

86

Q8NFX7
GDTLLGTASPENEFN

VPS13A

2011

Q96RL7
QSLAENGLEPFSQDG

TIAM1

66

Q13009
NGLEPFSQDGTLEDF

TIAM1

71

Q13009
FIQPGDLGSGDSQED

STAG3

846

Q9UJ98
SELDFAQGQPVAGTE

STAG3

1131

Q9UJ98
ENGELFEFADTPGNL

PROM2

511

Q8N271
NNQDFKGSAGAPSVE

PPM1A

81

P35813
SGDPQNLSDVDAFNL

TRABD

31

Q9H4I3
IVDTPGFGDAVDNSN

SEPTIN7

111

Q16181
GDFLNDNAVEIPSFS

WDHD1

336

O75717
FNNGAPGSLENDENR

ARHGAP31

216

Q2M1Z3
NEAPEGNLGDFAEFQ

GTF3C4

226

Q9UKN8
NLFGESAGDPQESIV

ARHGAP18

121

Q8N392
NNSDIAEDGGQTPYE

NSD3

36

Q9BZ95
FAGNSPAREGEQDAA

ZC3H4

1271

Q9UPT8
EQQFGPGAARDSQAE

ZBTB20

391

Q9HC78
EPGENATLSYDQNDG

ZNF644

901

Q9H582
GEGFFPDQARAENLA

TOR4A

381

Q9NXH8
VGNGDIDTPFEVSQF

TSNAX

206

Q99598
NSLEDFFPQGADLET

ZBED6

776

P86452
SVHPNSDFFGQEGET

ZXDA

756

P98168
FFEQGDVPSQVEAGL

ZNF230

116

Q9UIE0
HGAEDEEAPSQQGFS

ZNF548

51

Q8NEK5
ENNPFAKGFRGSDDS

TBX4

241

P57082
TANSDPGIAVGFDEF

THBS2

991

P35442
SPRGFEAGFENEDNS

ZSCAN29

561

Q8IWY8
NDSFQVLQGDGPDSA

SLC9A7

571

Q96T83
FPENLTNGATADNGD

POTEH

466

Q6S545
SDIIDSSALNGGFQP

UNC5C

411

O95185
EQFGGNPFATATTDN

UBQLN3

271

Q9H347
FFSEEGTGKENEPQQ

ZNF106

876

Q9H2Y7
FQPQGGDIGQDSSDD

SKAP1

56

Q86WV1
VDGNSQFGFSDQPSL

PPIP5K1

1186

Q6PFW1
QEPNSFFDGIGADAT

ZFY

11

P08048
GTQFSDAEGLALPQD

LTB

116

Q06643
NLASGEVGFFPSDAV

VAV3

641

Q9UKW4
SPQGSFLEDTTGEQF

ADAMTSL3

41

P82987