Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyCellularComponentMCM complex

MMS22L MCM8

1.94e-0411402GO:0042555
DomainAAA+_ATPase

RNF213 MCM8 ATAD2B

3.11e-03144383IPR003593
DomainAAA

RNF213 MCM8 ATAD2B

3.11e-03144383SM00382
DomainIntermediate_filament_CS

KRT14 SYNM

7.28e-0363382IPR018039
DomainFilament

KRT14 SYNM

9.17e-0371382SM01391
DomainIF

KRT14 SYNM

9.42e-0372382PS00226
DomainFilament

KRT14 SYNM

9.67e-0373382PF00038
DomainIF

KRT14 SYNM

1.04e-0276382IPR001664
Pubmed

Tumor type-dependent function of the par3 polarity protein in skin tumorigenesis.

KRT14 PARD3

1.29e-06240222975380
Pubmed

Polarity signaling ensures epidermal homeostasis by coupling cellular mechanics and genomic integrity.

KRT14 PARD3

1.29e-06240231358743
Pubmed

Essential Role of Polarity Protein Par3 for Epidermal Homeostasis through Regulation of Barrier Function, Keratinocyte Differentiation, and Stem Cell Maintenance.

KRT14 PARD3

1.29e-06240227452221
Pubmed

Shared and independent functions of aPKCλ and Par3 in skin tumorigenesis.

KRT14 PARD3

3.87e-06340229789715
Pubmed

The epidermal polarity protein Par3 is a non-cell autonomous suppressor of malignant melanoma.

KRT14 PARD3

7.73e-06440228096290
Pubmed

Interactions of the Antiviral Factor Interferon Gamma-Inducible Protein 16 (IFI16) Mediate Immune Signaling and Herpes Simplex Virus-1 Immunosuppression.

DHX36 RNF213 LARP4B HUWE1 SYNE1

3.85e-0533240525693804
Pubmed

A High-Density Human Mitochondrial Proximity Interaction Network.

DHX36 MTIF3 RNF213 LARP4B HUWE1 PPAT TTC3 SYNM SYNE1

4.02e-05149640932877691
Pubmed

The NF2 tumor suppressor, Merlin, regulates epidermal development through the establishment of a junctional polarity complex.

KRT14 PARD3

4.62e-05940221074722
Pubmed

CD44 regulates tight-junction assembly and barrier function.

KRT14 PARD3

5.77e-051040221191420
Pubmed

Overexpression of Flii during Murine Embryonic Development Increases Symmetrical Division of Epidermal Progenitor Cells.

KRT14 PARD3

1.16e-041440234361001
Pubmed

Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system.

RNF213 HUWE1 FBXO4

1.30e-048540319028597
Pubmed

Epithelial expression of Gata4 and Sox2 regulates specification of the squamous-columnar junction via MAPK/ERK signaling in mice.

KRT14 SYNE1

1.53e-041640233495473
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

KNTC1 RNF213 LARP4B ZMYM1 HUWE1 SF3B2

1.79e-0473340634672954
Pubmed

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity.

RNF213 HUWE1 TTC3

1.81e-049540329643511
Pubmed

Comparative proteomic analysis of intra- and interindividual variation in human cerebrospinal fluid.

C3 CHGB

1.95e-041840216199891
Pubmed

Huntingtin regulates mammary stem cell division and differentiation.

KRT14 PARD3

1.95e-041840224749073
Pubmed

De novo lumen formation and elongation in the developing nephron: a central role for afadin in apical polarity.

PARD3 CDH4

1.95e-041840223487309
Pubmed

Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.

DHX36 HUWE1 GPC3 SF3B2

1.97e-0425140428077445
Pubmed

Tissue-Specific Regulation of the Wnt/β-Catenin Pathway by PAGE4 Inhibition of Tankyrase.

DHX36 KRT14 HUWE1 SF3B2

2.13e-0425640432698014
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

RNF213 KRT14 HUWE1 PARD3 SYNM PLEKHA8

2.45e-0477740635844135
Pubmed

A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.

LARP4B GPC3 PARD3 TTC3 SYNE1

2.54e-0449740523414517
Pubmed

UBE2S interacting with TRIM21 mediates the K11-linked ubiquitination of LPP to promote the lymphatic metastasis of bladder cancer.

RNF213 NANS

2.67e-042140237422473
Pubmed

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation.

KRT14 PARD3

4.45e-042740227807348
Pubmed

Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.

MCM8 NANS CARD8 UGT3A1

4.56e-0431340420800603
Pubmed

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.

KNTC1 KRT14 HUWE1 EYA3 HOOK1

5.48e-0458840538580884
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

KNTC1 DHX36 MMS22L FBXO4 PARD3 HOOK1 SF3B2

5.89e-04128440717353931
Pubmed

SARS-CoV-2 uses Spike glycoprotein to control the host's anaerobic metabolism by inhibiting LDHB.

C3 HUWE1 PPAT NANS SF3B2

6.33e-0460740539147351
Pubmed

The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function.

LARP4B HUWE1

6.66e-043340222357600
Pubmed

MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.

LARP4B HUWE1 PARD3 CDH4

7.53e-0435840432460013
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

DHX36 LARP4B HUWE1 SF3B2 ATAD2B

8.78e-0465340522586326
Pubmed

Cdc42 controls progenitor cell differentiation and beta-catenin turnover in skin.

KRT14 PARD3

9.30e-043940216510873
Pubmed

Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.

KNTC1 DHX36 HUWE1 PPAT TTC3 SF3B2 SYNE1

1.09e-03142540730948266
Pubmed

Identification of Novel Proteins Co-Purifying with Cockayne Syndrome Group B (CSB) Reveals Potential Roles for CSB in RNA Metabolism and Chromatin Dynamics.

DHX36 SF3B2

1.13e-034340226030138
CoexpressionAtlasdev gonad_e11.5_F_PrimGermCell_Oct_k-means-cluster#3_top-relative-expression-ranked_1000

KNTC1 MMS22L ZMYM1 PPAT HOOK1 MCM8 NANS

1.57e-05463387gudmap_dev gonad_e11.5_F_PrimGermCell_Oct_k3_1000
ToppCellCV-Severe-7|Severe / Virus stimulation, Condition and Cluster

RNF213 MMS22L ZMYM1 HUWE1 TRPC3

4.60e-0717739582fdd6185b368f54f03de389427cbe3071d21a99
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_G2M|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

C3 MMS22L KRT14 GPC3

1.75e-05178394c77a1d1a9aef0ab51b4408b9e84f201219788ca2
ToppCellfacs-Kidney-nan-24m-Mesenchymal-kidney_interstitial_fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C3 MMS22L GPC3 MCM8

1.87e-051813940ec9621a078d004bbd25a587757d24b5cf162959
ToppCellfacs-Kidney-nan-24m-Mesenchymal-kidney_interstitial_fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C3 MMS22L GPC3 MCM8

1.87e-05181394c7f5aedcb74c21fb587a95a16d700e2a38a380ee
ToppCellCV-Moderate-7|Moderate / Virus stimulation, Condition and Cluster

KNTC1 RNF213 MMS22L HUWE1

2.03e-05185394a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCellCV-Moderate-7|CV / Virus stimulation, Condition and Cluster

KNTC1 RNF213 MMS22L HUWE1

2.08e-051863948571956890fc9894d766ba294a28e376b4aba428
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

CCDC102B PARD3 SYNM TRPC3

2.12e-0518739486250acf088ec0c4800a0dfa031b0d4f7e52c342
ToppCellCD8+_Memory_T_cell-CV-7|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

KNTC1 RNF213 MMS22L HUWE1

2.30e-051913949454f642c3621370fa23640b631301346b300950
ToppCellCV-Moderate-6|CV / Virus stimulation, Condition and Cluster

DHX36 HUWE1 TXNL4A TTC3

2.55e-051963947bced0cc2112697593c478fa291b8ed3941fb811
ToppCellTracheal-NucSeq-Stromal-Fibroblastic|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

C3 CCDC102B GPC3 SYNE1

2.76e-05200394b4ccffdd79526c85e5273d27b668dbddcddba1ee
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

C3 CCDC102B GPC3 SYNE1

2.76e-052003943dd022e974fec7013ba18f333da63f58fbf2dd7c
ToppCellTracheal-NucSeq-Stromal-Fibroblastic-Fibro_adventitial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

C3 CCDC102B GPC3 SYNE1

2.76e-052003940c25d56292b9e5fefa4521b72635449be1ffd6fe
ToppCellmild-immature_Neutrophil|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

KNTC1 MMS22L EYA3

1.19e-041093932f03d6ee8b13424cc6a5bc60ac3461b44dff9d79
ToppCellMyeloid-Myeloid-E_(Neutrophils)|Myeloid / shred on cell class and cell subclass (v4)

PPAT CDH4 SYNE1

3.04e-041503931bffb8d86b737ac43be902d9468041aef3542f1f
ToppCellLPS_only-Epithelial_alveolar-AT_1-AT2_Progenitor|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ATP13A4 HOOK1 NANS

3.22e-04153393e7a074ea8232bacf924be78a244a8507c7e1ebc8
ToppCellfacs-Marrow-B-cells-24m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C3 SYNE1 UGT3A1

3.28e-0415439346155f36d3983f637b55d7525b675c8828f6ab2e
ToppCellfacs-Marrow-B-cells-24m-Myeloid-granulocytopoietic_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C3 SYNE1 UGT3A1

3.28e-0415439371ffc23a2e02e27cabbdbeaa622e59e9f4a4cd9d
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c04-COTL1|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

ATP13A4 PARD3 SYNE1

3.74e-04161393bf4bfb416cb6ef43fc8cf0ffc2d7f0b6b42ab4da
ToppCellClub-club-13|World / Class top

C3 LARP4B NANS

3.81e-041623937d18f05a65ac715e62d610df9cc4a26539340dee
ToppCell390C-Myeloid-Dendritic-cDC_proliferating_2|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

KNTC1 CHGB SYNM

4.02e-04165393a5c3af634d2698f9a01cf074791756b7669f9fff
ToppCelldroplet-Pancreas-Exocrine-24m-Epithelial-pancreatic_acinar_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT14 GPC3 PLEKHA8

4.02e-04165393622aca1d49bd8c917b131e4f4959d9dba411d22b
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

C3 KRT14 GPC3

4.16e-04167393351f8de1fbdf742ac74f9099b254d515ab539bb2
ToppCellPND14-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

C3 KRT14 GPC3

4.16e-04167393c042d6cdddd0e1ddef1e3ac6f4fe23151127b0f2
ToppCelldroplet-Pancreas-Exocrine-24m-Epithelial-pancreatic_acinar_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT14 GPC3 PLEKHA8

4.16e-041673933c06894fc6177f3c204094719904da42f08b9af8
ToppCellControl|World / group, cell type (main and fine annotations)

ATP13A4 PARD3 SYNE1

4.23e-04168393a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

ATP13A4 LARP4B PARD3

4.38e-04170393a2c738e441ced90eeeb1fcc6ca3269b918aaa298
ToppCellP07-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

C3 KRT14 GPC3

4.53e-041723939a256db817c1af1802203cc88a55d608fb328c63
ToppCelldroplet-Marrow-nan-3m-Myeloid-granulocyte|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C3 BPGM SYNE1

4.53e-04172393d354424c1f861b6607dfd63b9724f4c237b30275
ToppCell5'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CHGB GPC3 CDH4

4.53e-04172393bd01b39a5699824ab14827cc9dc98e547d65b160
ToppCellAdult-Mesenchymal-pericyte_cell-D231|Adult / Lineage, Cell type, age group and donor

CCDC102B SYNM TRPC3

4.53e-04172393858cee96c1c06160863b4adcd7023c0d678bd50f
ToppCellAdult-Mesenchymal-pericyte_cell-D175|Adult / Lineage, Cell type, age group and donor

CCDC102B SYNM TRPC3

4.61e-04173393fd6653d6be9ca6ac36798590694efe03cb758c67
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

C3 KRT14 GPC3

4.61e-0417339330d67738633493d47f06ae452424382f069b6c0a
ToppCell5'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CHGB GPC3 CDH4

4.69e-04174393911eac6f6ec1e5e85348a7fe774243498388a810
ToppCellPND03-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

C3 KRT14 GPC3

4.69e-04174393a9c6edf5c3fc119c24425f921c5566a8356c30fe
ToppCelldroplet-Marrow-nan-3m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C3 CHGB SYNE1

4.77e-04175393cf53a15bfb37b6019e7052ffdf594a9ac040900e
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c05-ZNF683|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

RNF213 BPGM SYNE1

4.85e-041763935914e7635474e7cf24d446bdb1423bc0807ee9c6
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ATP13A4 PARD3 SYNE1

4.85e-04176393327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCellCV-Severe-7|CV / Virus stimulation, Condition and Cluster

RNF213 ZMYM1 HUWE1

4.85e-041763933de0c7d77210049e5616db21eed1490a17a5ec2d
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ATP13A4 CDH4 SYNE1

4.93e-04177393da8802a6351d3e510822f82e2fde8a4314a2216e
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.1.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC102B SYNM TRPC3

4.93e-04177393452ec2df36c6d656a7cdadc55be545ccdb146a29
ToppCell3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(C7+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

C3 CCDC102B GPC3

4.93e-041773937af1a19692f7fe8f691178a4e57d62bc379e3d56
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

CCDC102B SYNM TRPC3

5.01e-04178393185b44700f06ec58b3c09c80520502166c965fd6
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial-Mesothelial_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

C3 KRT14 GPC3

5.01e-04178393c413861148129be1ee94f2ceb5999840217eebe5
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_PAX6-Inh_L1_PAX6_CA4|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KRT14 GPC3 CDH4

5.01e-04178393e86ed30652c2de70f16430f04b78789b87df4af2
ToppCellP28-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

C3 KRT14 GPC3

5.01e-041783931e05bc26591fea16e29bcfc5f538dda1dc427f05
ToppCellE18.5-Mesenchymal-Mesenchymal_structural-Fibroblastic-Mesothelial|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

C3 KRT14 GPC3

5.01e-04178393bcbdd45a2307f8aea14122fa0144b96b1f6eec48
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_S-high|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KNTC1 MMS22L MCM8

5.09e-0417939388d44b04eb5c079531db663ed98ddb20b60feb9a
ToppCellLPS-antiTNF-Epithelial_alveolar-AT_2-AT2_Progenitor|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

C3 HOOK1 NANS

5.09e-041793937db6b97a1c4c7a163d5da4351ba36ac1785d9d7b
ToppCellP03-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

C3 KRT14 GPC3

5.18e-041803932ccc77d769d3ffd77ab3af45e4f192785b6db79c
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHGB TTC3 TRPC3

5.18e-04180393f6a2208960d0df1500c974cc44c3c054cd7475a9
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

CCDC102B SYNM TRPC3

5.26e-04181393451b87ac95154bb80018b8dd245b4a6389d81411
ToppCellfacs-Marrow-T-cells-3m-Hematologic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HUWE1 BPGM HOOK1

5.26e-0418139357f0cc749ae8b6a3d77e2af31f9a6e4739c57049
ToppCellfacs-Marrow-T-cells-3m-Hematologic-hematopoietic_stem_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HUWE1 BPGM HOOK1

5.26e-04181393d01b35cc2fc57991a35be6a06cb7351fbabd9a11
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_T_CD8-Trm/em_CD8|lymph-node_spleen / Manually curated celltypes from each tissue

RNF213 SYNM SYNE1

5.35e-04182393f857b32de19240a8aca1685f7a78b4e53b04875c
ToppCellCOPD-Epithelial-ATII|World / Disease state, Lineage and Cell class

ATP13A4 PARD3 SYNE1

5.43e-041833938e9aab4eeec2e282c2cab9bfca6dbf40d660c7b9
ToppCellAdult-Mesenchymal-pericyte_cell-D122|Adult / Lineage, Cell type, age group and donor

CCDC102B SYNM TRPC3

5.43e-04183393fc31a43a637423cb3bb9aa184a3a889a0b9aaea6
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C3 KRT14 GPC3

5.52e-04184393c9d7ec17cc5b7ba1b1e721ca392746e8f4a3d41f
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_2-AT2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

C3 HOOK1 NANS

5.52e-04184393157a3d00165bb4a8c52c3e63ae57d9cf57500be7
ToppCellCOVID-19-Fibroblasts-Pericytes|COVID-19 / group, cell type (main and fine annotations)

CCDC102B PARD3 TRPC3

5.61e-041853934905adaeeffd353e089578e5ea614437dbe794e6
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_2-AT2_Progenitor|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

C3 HOOK1 NANS

5.61e-04185393929b68b05b7686341329ac756d7df172cb4b810b
ToppCellFetal_29-31_weeks-Mesenchymal-pericyte_cell-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CCDC102B SYNM TRPC3

5.61e-04185393a7dba7db79275884b2a93d8a16f2e0c739e71370
ToppCellCOVID-19-Fibroblasts-Adventitial_FB|COVID-19 / group, cell type (main and fine annotations)

C3 CCDC102B PARD3

5.61e-04185393a5aebf2b9b05b550d021272731d68af9a6b1229d
ToppCellCOPD-Stromal-Pericyte|World / Disease state, Lineage and Cell class

CCDC102B PARD3 TRPC3

5.69e-041863938adfd2d1fda4e8aecc95192ea627bf7ed5214b8d
ToppCellE12.5-Mesenchymal-mesenchymal_fibroblast-mesothelial_cell_of_visceral_pleura|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

RNF213 KRT14 GPC3

5.69e-041863931587667e5084ac43505d027af925ba711e228150
ToppCellLPS_only-Epithelial_alveolar|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

C3 ATP13A4 HOOK1

5.69e-04186393e0a2ea4b46af742bc7c9b2072bb85e27d5c92712
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes-Pericytes_L.2.3.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC102B SYNM TRPC3

5.69e-04186393888e85a025bd982d36c910db0f5a3385b1ca3b28
ToppCellfacs-Skin-Telogen-3m-Epithelial-basal_cell_of_epidermis|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT14 TTC3 CDH4

5.78e-041873939c1013720c248ef201d010806b6e7ad24205e8ee
ToppCellLPS_only-Epithelial_alveolar-AT_1|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

C3 ATP13A4 HOOK1

5.78e-04187393ff26a533d310126521efe1d05cf8b9d32e524550
ToppCellmild_COVID-19-CD4+_CTL|mild_COVID-19 / disease group, cell group and cell class (v2)

RNF213 SYNM SYNE1

5.78e-0418739349196d07e4716c87d33229a4569bdb6b4613b3eb
ToppCellFetal_29-31_weeks-Mesenchymal-pericyte_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CCDC102B SYNM TRPC3

5.78e-04187393fa01a61bfd13feb033ba1e35cf513707b1bff8c8
ToppCellAdult-Mesenchymal-pericyte_cell|Adult / Lineage, Cell type, age group and donor

CCDC102B SYNM TRPC3

5.78e-0418739362759efb660179402fb574ce5701c89a2e17bcfe
ToppCellLPS-antiTNF-Epithelial_alveolar|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

C3 ATP13A4 HOOK1

5.78e-04187393201ff693e4756ee3e44762885b3a303a77eb535b
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_NK-NK_dim-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

RNF213 BPGM SYNE1

5.78e-041873930bca79cea4886b66350c56c61859bd71e1e7a85c
ToppCellFetal_29-31_weeks-Mesenchymal-pericyte_cell|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CCDC102B SYNM TRPC3

5.78e-04187393a2bf958ea59c359a265bfa437d59315e1920cdd4
ToppCellLPS-IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

C3 ATP13A4 HOOK1

5.87e-041883934bdf8d49af0e9da349b16e3f012e1b0eec04cc4f
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ATP13A4 PARD3 SYNE1

5.87e-0418839363a4b25a0a6e05f80f1a6dd91b817f3cf49e6b68
ToppCellChildren_(3_yrs)-Mesenchymal-pericyte_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

CCDC102B SYNM TRPC3

5.87e-04188393ee151792c7ac9afe820f1a281c6dab383799f358
ToppCellFetal_29-31_weeks-Mesenchymal-pericyte_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CCDC102B SYNM TRPC3

5.87e-04188393ccddc08121caff958a2b6f9e278a018858af6b4d
ToppCelldroplet-Lung-nan-21m-Lymphocytic-Proliferating_T|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KNTC1 MMS22L MCM8

5.87e-0418839361ae7405ab56570409bf35382dc0a038e4137c15
ToppCellLPS-IL1RA+antiTNF-Epithelial_alveolar|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

C3 ATP13A4 HOOK1

5.87e-0418839343a0508d2524a5b310e89e9422843dcaab999bc3
ToppCellfacs-Skin-Telogen-3m-Epithelial-Basal_IFE|Skin / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KRT14 TTC3 CDH4

5.87e-041883938cc927b4c51d982fdafa04dc7393617ad9bb220e
ToppCellMesenchymal-pericyte_cell|World / Lineage, Cell type, age group and donor

CCDC102B SYNM TRPC3

5.97e-04189393d7ed96add29f219183c802895fbff519b627f635
ToppCelltumor_Lung-Fibroblasts-Pericytes|Fibroblasts / Location, Cell class and cell subclass

CCDC102B SYNM TRPC3

5.97e-041893939c407b17d7945e81e1ae6c18452f5d20fb09d563
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CCDC102B SYNE1 TRPC3

5.97e-041893937ab1cfc1657277858339f7258a0c4ae9cb42fdf8
ToppCellnormal_Lung-Fibroblasts-Undetermined|normal_Lung / Location, Cell class and cell subclass

C3 CCDC102B GPC3

6.06e-0419039330d4658bcc6796f0cdf54cc029f4bb904b13ef66
ToppCellIPF-Epithelial-Basal|IPF / Disease state, Lineage and Cell class

KRT14 PARD3 HOOK1

6.06e-04190393ea19e9ce954f2dfde97388db9695325cd92ab88f
ToppCell15-Distal-Mesenchymal-Mesenchyme_SERPINF1-high|Distal / Age, Tissue, Lineage and Cell class

C3 CCDC102B GPC3

6.06e-04190393b47472dc9fe6ed99c2365203a3d8a59879e74a70
ToppCellnucseq-Mesenchymal-Myocytic-Myocytic_1-Pericyte|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CCDC102B SYNM TRPC3

6.06e-041903934eb92aef1ee868f4537483d19014d947b7684612
ToppCellnucseq-Mesenchymal-Myocytic-Myocytic_1|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

CCDC102B SYNM TRPC3

6.06e-041903937be4341e2909101d756f14031c21e705eb45e69a
ToppCellPCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

KNTC1 MMS22L MCM8

6.06e-04190393e83fa8b711aa79a1767818474f1c193b674b1c31
ToppCellpdx-Tumor_cells-T1|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

KNTC1 MMS22L MCM8

6.06e-04190393d06ee5f89f1cec8db6897fe3b2a890a07cd3697b
ToppCellkidney_cells-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

CHGB EYA3 UGT3A1

6.06e-04190393078f4be52fa4cc8dd9c8d7a2b6d9631c3d902285
ToppCellfacs-Pancreas-Endocrine-3m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CHGB HOOK1 GOLM2

6.15e-04191393f76f3f5c7902a3659d8cbe470f96ce57c8a6744d
ToppCellPCW_07-8.5-Mesenchymal-Mesenchymal_fibroblastic-mes_immature_COL13A1^pos_fibro1_(4)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

CCDC102B GPC3 CDH4

6.15e-04191393fa380a8752de158974b2ae5e741573439719cc0d
ToppCellLPS-IL1RA-Stromal_mesenchymal-Lung_smooth_muscle|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CCDC102B SYNE1 TRPC3

6.15e-041913937853ac7dff649150e6ff27cd4c8cf7c1fc034ed4
ToppCelldroplet-Lung-21m-Hematologic-lymphocytic-Proliferating_T_cell-proliferating_T|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

KNTC1 MMS22L MCM8

6.15e-0419139315dbc5a03bfab8931c0fd385b0f25874736ae874
ToppCell5'-Adult-LymphNode-Mesenchymal|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

C3 CCDC102B GPC3

6.15e-04191393054e9a79bd1486fd812bc7418fb091664fe3a646
ToppCell3'-Parenchyma_lung-Mesenchymal-Mesenchymal_Myocytic-pericyte_cell-Pericytes|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CCDC102B SYNM TRPC3

6.15e-04191393716dfa7fccbd62b5f574792e68a26dc6c45511dc
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal-mesenchymal_stem_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

C3 KRT14 GPC3

6.15e-041913931b26056df078674f37a6c06f6256b30cfcec21a7
ToppCellLPS_only-Stromal_mesenchymal-Lung_smooth_muscle|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CCDC102B SYNE1 TRPC3

6.15e-0419139308042952431ca1a6fd7dfc13f36eb28643979598
Drugpulegones

SAGE1 CHGB SYNE1

6.05e-0621393CID000006988
Drug4-phenylthiosemicarbazide

C3 SYNE1

8.57e-063392CID000730679
DiseaseEmery-Dreifuss muscular dystrophy (implicated_via_orthology)

HOOK1 SYNE1

1.06e-0412382DOID:11726 (implicated_via_orthology)
Diseaseestradiol measurement

MCM8 PLEKHA8 UGT3A1

3.87e-04110383EFO_0004697
Diseaselipoprotein-associated phospholipase A(2) measurement

RNF213 GOLM2

1.22e-0340382EFO_0004746
Diseasehemolysis

HOOK1 ATAD2B

1.68e-0347382EFO_0009473

Protein segments in the cluster

PeptideGeneStartEntry
KGQHALLNEGEENEM

ATP13A4

6

Q4VNC1
NKMFSRHNEGDDQQG

FBXO4

256

Q9UKT5
HQEMIGGLRNNNEKD

C3

1126

P01024
GDGRDEEIAAKQHNM

EYA3

536

Q99504
QKGNMEVARIHAENA

CHMP1B

41

Q7LBR1
GIDEFDKMGNQHQAL

MCM8

516

Q9UJA3
AARNGMKNQFNLHEL

GPC3

436

P51654
KNHEEEMNALRGQVG

KRT14

251

P02533
HLGQMGQDEMQRLEN

MMS22L

1226

Q6ZRQ5
DIMDLDQGQRLNNGA

ATAD2B

1211

Q9ULI0
QRVQEGKDSAHLMNG

LARP4B

16

Q92615
DEKGNDLGNMHRANV

MTIF3

91

Q9H2K0
KQLEEHMNTGQLAGF

KNTC1

2106

P50748
IGLNREQMALNHGEE

BPGM

96

P07738
RKEDGMENLKNHDNN

PLEKHA8

271

Q96JA3
GMNGIQKFQIHRDDR

HUWE1

4316

Q7Z6Z7
GFMQGHVNRQEKEEK

DHX36

421

Q9H2U1
GNEGNQEMLQEIKNR

HEATR4

861

Q86WZ0
ENHRQLQARMGDLKG

CARD8

456

Q9Y2G2
RAHAVDMNGNKVENP

CDH4

246

P55283
QHENKMLRLQQEGSE

HOOK1

471

Q9UJC3
LGEGHHRVQENQMDK

CHGB

441

P05060
LLGQHNDEMQELSGN

CCDC102B

316

Q68D86
DMRGNPGQSLQHKEN

OR1E3

296

Q8WZA6
SHSLERQMNGNQEKG

PARD3

971

Q8TEW0
VEEEMQKHGSNNVGL

POTEA

341

Q6S8J7
GQQMKELRAQHEENI

GOLM2

166

Q6P4E1
EQVSQEVHQGLKDMG

TCP11X2

286

Q5H9J9
RALHDKQLNMQGTAQ

SYNE1

6181

Q8NF91
EGDQAHREQGKEQAM

SYNM

1511

O15061
GQNHQGDLDVAKRMI

NANS

26

Q9NR45
VKQQGLRQDHPGQMD

RNF213

4311

Q63HN8
LLMQQEERAKQQGDH

SF3B2

156

Q13435
NGDQHGNMVRVVAKN

UGT3A1

391

Q6NUS8
VHEARMENGQRKQDN

SAGE1

441

Q9NXZ1
KKHDIMIQENGNGLE

PPAT

481

Q06203
RKINHEMANGGNQNL

TTC3

396

P53804
LQQIGVDMDKIHGQA

ZMYM1

701

Q5SVZ6
RNKHIMIDLGTGNNN

TXNL4A

86

P83876
MGQNALQLAVGNEHL

TRPC3

61

Q13507