Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	arachidonate 8(R)-lipoxygenase activity	ALOX12B ALOX15B	4.32e-06	2	42	2	GO:0047677
GeneOntologyMolecularFunction	linoleate 9S-lipoxygenase activity	ALOX12B ALOX15B	4.32e-06	2	42	2	GO:1990136
GeneOntologyMolecularFunction	iron ion binding	CYP2D7 CYP2J2 ALOX12B ALOX15B	4.03e-04	166	42	4	GO:0005506
GeneOntologyMolecularFunction	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	ALOX12B ALOX15B	1.26e-03	25	42	2	GO:0016702
GeneOntologyMolecularFunction	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	ALOX12B ALOX15B	1.36e-03	26	42	2	GO:0016701
GeneOntologyMolecularFunction	arachidonate monooxygenase activity	CYP2D7 CYP2J2	1.47e-03	27	42	2	GO:0008391
GeneOntologyMolecularFunction	aromatase activity	CYP2D7 CYP2J2	2.46e-03	35	42	2	GO:0070330
GeneOntologyMolecularFunction	transition metal ion binding	CYLD TRIM77 TUT4 CYP2D7 CYP2J2 LOXL1 ALOX12B ALOX15B	2.97e-03	1189	42	8	GO:0046914
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	CYP2D7 CYP2J2	4.77e-03	49	42	2	GO:0016712
GeneOntologyMolecularFunction	oxidoreductase activity	CYP2D7 SARDH CYP2J2 LOXL1 ALOX12B ALOX15B	5.04e-03	766	42	6	GO:0016491
GeneOntologyBiologicalProcess	arachidonate metabolic process	CYP2D7 CYP2J2 ALOX12B ALOX15B	9.03e-06	68	40	4	GO:0019369
GeneOntologyBiologicalProcess	linoleic acid metabolic process	CYP2J2 ALOX12B ALOX15B	1.16e-05	23	40	3	GO:0043651
GeneOntologyBiologicalProcess	long-chain fatty acid metabolic process	CYP2D7 CYP2J2 ALOX12B ALOX15B	9.62e-05	124	40	4	GO:0001676
GeneOntologyBiologicalProcess	hepoxilin metabolic process	ALOX12B ALOX15B	1.02e-04	8	40	2	GO:0051121
GeneOntologyBiologicalProcess	hepoxilin biosynthetic process	ALOX12B ALOX15B	1.02e-04	8	40	2	GO:0051122
GeneOntologyBiologicalProcess	unsaturated fatty acid metabolic process	CYP2D7 CYP2J2 ALOX12B ALOX15B	1.09e-04	128	40	4	GO:0033559
GeneOntologyBiologicalProcess	icosanoid metabolic process	CYP2D7 CYP2J2 ALOX12B ALOX15B	1.62e-04	142	40	4	GO:0006690
GeneOntologyBiologicalProcess	lipoxygenase pathway	ALOX12B ALOX15B	1.99e-04	11	40	2	GO:0019372
Domain	DVL-1	DVL1P1 DVL1	4.47e-06	2	40	2	IPR008340
Domain	Dishevelled	DVL1P1 DVL1	2.68e-05	4	40	2	PF02377
Domain	Dishevelled_protein_dom	DVL1P1 DVL1	2.68e-05	4	40	2	IPR003351
Domain	Dishevelled_fam	DVL1P1 DVL1	2.68e-05	4	40	2	IPR008339
Domain	LIPOXYGENASE_2	ALOX12B ALOX15B	6.67e-05	6	40	2	PS00081
Domain	LipOase	ALOX12B ALOX15B	6.67e-05	6	40	2	IPR000907
Domain	LipOase_Fe_BS	ALOX12B ALOX15B	6.67e-05	6	40	2	IPR020833
Domain	LipOase_CS	ALOX12B ALOX15B	6.67e-05	6	40	2	IPR020834
Domain	LipOase_mml	ALOX12B ALOX15B	6.67e-05	6	40	2	IPR001885
Domain	LIPOXYGENASE_1	ALOX12B ALOX15B	6.67e-05	6	40	2	PS00711
Domain	LipOase_C	ALOX12B ALOX15B	6.67e-05	6	40	2	IPR013819
Domain	Lipoxygenase	ALOX12B ALOX15B	6.67e-05	6	40	2	PF00305
Domain	LIPOXYGENASE_3	ALOX12B ALOX15B	6.67e-05	6	40	2	PS51393
Domain	DIX	DVL1P1 DVL1	9.33e-05	7	40	2	IPR001158
Domain	DIX	DVL1P1 DVL1	9.33e-05	7	40	2	PS50841
Domain	DAX	DVL1P1 DVL1	9.33e-05	7	40	2	SM00021
Domain	DIX	DVL1P1 DVL1	9.33e-05	7	40	2	PF00778
Domain	Beach	WDR81 NBEAL2	1.59e-04	9	40	2	PF02138
Domain	-	WDR81 NBEAL2	1.59e-04	9	40	2	1.10.1540.10
Domain	BEACH_dom	WDR81 NBEAL2	1.59e-04	9	40	2	IPR000409
Domain	Beach	WDR81 NBEAL2	1.59e-04	9	40	2	SM01026
Domain	BEACH	WDR81 NBEAL2	1.59e-04	9	40	2	PS50197
Domain	LH2	ALOX12B ALOX15B	6.70e-04	18	40	2	SM00308
Domain	PLAT	ALOX12B ALOX15B	9.15e-04	21	40	2	PF01477
Domain	PLAT	ALOX12B ALOX15B	9.15e-04	21	40	2	PS50095
Domain	PLAT/LH2_dom	ALOX12B ALOX15B	9.15e-04	21	40	2	IPR001024
Domain	-	ALOX12B ALOX15B	9.15e-04	21	40	2	2.60.60.20
Domain	DEP	DVL1P1 DVL1	1.01e-03	22	40	2	PF00610
Domain	DEP	DVL1P1 DVL1	1.01e-03	22	40	2	SM00049
Domain	DEP	DVL1P1 DVL1	1.01e-03	22	40	2	PS50186
Domain	DEP_dom	DVL1P1 DVL1	1.10e-03	23	40	2	IPR000591
Pathway	KEGG_ARACHIDONIC_ACID_METABOLISM	CYP2J2 ALOX12B ALOX15B	2.48e-04	58	30	3	M5410
Pathway	REACTOME_ARACHIDONIC_ACID_METABOLISM	CYP2J2 ALOX12B ALOX15B	2.61e-04	59	30	3	M27140
Pathway	REACTOME_ARACHIDONIC_ACID_METABOLISM	CYP2J2 ALOX12B ALOX15B	2.88e-04	61	30	3	MM14861
Pathway	REACTOME_FATTY_ACID_METABOLISM	ACACB CYP2J2 ALOX12B ALOX15B	4.38e-04	170	30	4	MM15573
Pathway	REACTOME_FATTY_ACID_METABOLISM	ACACB CYP2J2 ALOX12B ALOX15B	4.99e-04	176	30	4	M27854
Pathway	REACTOME_FATTY_ACIDS	CYP2D7 CYP2J2	6.56e-04	18	30	2	MM14841
Pubmed	Sequence determinants for the reaction specificity of murine (12R)-lipoxygenase: targeted substrate modification and site-directed mutagenesis.	ALOX12B ALOX15B	1.64e-06	2	45	2	16129665
Pubmed	Human homologue sequences to the Drosophila dishevelled segment-polarity gene are deleted in the DiGeorge syndrome.	DVL1P1 DVL1	1.64e-06	2	45	2	8644734
Pubmed	Novel mutations in ALOX12B in patients with autosomal recessive congenital ichthyosis and evidence for genetic heterogeneity on chromosome 17p13.	ALOX12B ALOX15B	4.91e-06	3	45	2	17139268
Pubmed	cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene.	DVL1P1 DVL1	9.81e-06	4	45	2	8817329
Pubmed	cDNA cloning of a 8-lipoxygenase and a novel epidermis-type lipoxygenase from phorbol ester-treated mouse skin.	ALOX12B ALOX15B	9.81e-06	4	45	2	9518531
Pubmed	Human dishevelled genes constitute a DHR-containing multigene family.	DVL1P1 DVL1	9.81e-06	4	45	2	9192851
Pubmed	Non-canonical Wnt signaling induces ubiquitination and degradation of Syndecan4.	DVL1P1 DVL1	9.81e-06	4	45	2	20639201
Pubmed	A gene cluster encoding human epidermis-type lipoxygenases at chromosome 17p13.1: cloning, physical mapping, and expression.	ALOX12B ALOX15B	9.81e-06	4	45	2	11350124
Pubmed	CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation.	CYLD DVL1	1.63e-05	5	45	2	24469800
Pubmed	Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl.	CYLD DVL1	1.63e-05	5	45	2	20227366
Pubmed	A coated vesicle-associated kinase of 104 kDa (CVAK104) induces lysosomal degradation of frizzled 5 (Fzd5).	DVL1P1 DVL1	4.56e-05	8	45	2	19643732
Pubmed	Estrogen-regulated feedback loop limits the efficacy of estrogen receptor-targeted breast cancer therapy.	ZMYND15 CYLD TUT4 MINPP1 SARDH CYP2J2	2.44e-04	686	45	6	29987050
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	KRBA1 ACACB TAPBP NBEAL2 U2SURP	4.45e-04	497	45	5	36774506
Cytoband	Ensembl 112 genes in cytogenetic band chr17p13	ZMYND15 WDR81 ALOX12B ALOX15B	3.70e-04	346	45	4	chr17p13
GeneFamily	Arachidonate lipoxygenases	ALOX12B ALOX15B	3.46e-05	6	28	2	407
GeneFamily	WD repeat domain containing\|BEACH domain containing	WDR81 NBEAL2	8.27e-05	9	28	2	1230
GeneFamily	Cytochrome P450 family 2	CYP2D7 CYP2J2	1.33e-03	35	28	2	1001
Coexpression	THAKAR_PBMC_INACTIVATED_INFLUENZA_AGE_21_30YO_RESPONDERS_7DY_DN	ZMYND15 GPR137 ITPRIP KRBA1 TUT4 PNISR C6orf136 ARHGAP33	7.70e-06	634	43	8	M40866
Drug	15-H-11,12-EETA	CYP2D7 CYP2J2 ALOX12B ALOX15B	6.22e-07	36	43	4	CID011954042
Drug	11,14,15-THET	CYP2D7 CYP2J2 ALOX12B ALOX15B	8.64e-07	39	43	4	CID006439531
Drug	11,12,15-trihydroxyeicosatrienoic acid	CYP2D7 CYP2J2 ALOX12B ALOX15B	1.17e-06	42	43	4	CID006439610
Drug	17-ODYA	CYP2D7 CYP2J2 ALOX12B ALOX15B	4.98e-06	60	43	4	CID000001449
Drug	5,6-epoxyeicosatrienoic acid	CYP2D7 CYP2J2 ALOX12B ALOX15B	8.22e-06	68	43	4	CID000001778
Drug	8(9)-EET	CYP2D7 CYP2J2 ALOX12B ALOX15B	8.72e-06	69	43	4	CID000001901
Drug	C20H32O4	CYP2D7 CYP2J2 ALOX12B ALOX15B	1.42e-05	78	43	4	CID000001440
Drug	14(15)-EpETrE	CYP2D7 CYP2J2 ALOX12B ALOX15B	2.40e-05	89	43	4	CID000001431
Drug	11-H-14,15-EETA	CYP2D7 CYP2J2 ALOX15B	2.46e-05	30	43	3	CID011954058
Drug	AC1L1BEQ	CYP2D7 CYP2J2 ALOX12B ALOX15B	2.85e-05	93	43	4	CID000001407
Drug	14-hydroxydocosahexaenoic acid	ALOX12B ALOX15B	3.47e-05	5	43	2	CID006439735
Drug	artonin E	ALOX12B ALOX15B	3.47e-05	5	43	2	CID005481962
Drug	Pyrazinamide [ 98-96-4]; Up 200; 32.4uM; MCF7; HT_HG-U133A	GPR137 TUT4 ACACB ABCA7 ARHGAP33	3.56e-05	199	43	5	4962_UP
Drug	AC1O5XSP	CYP2D7 CYP2J2 ALOX15B	3.60e-05	34	43	3	CID006442739
Drug	isamoxole	ALOX12B ALOX15B	5.20e-05	6	43	2	CID000042118
Drug	1-oleoyl-2-DHA-PC	ALOX12B ALOX15B	5.20e-05	6	43	2	CID006438829
Drug	CPHU	ALOX12B ALOX15B	5.20e-05	6	43	2	CID000124471
Drug	BW A797C	ALOX12B ALOX15B	5.20e-05	6	43	2	CID006439067
Drug	proadifen hydrochloride	CYP2D7 LOXL1 ALOX12B ALOX15B	6.33e-05	114	43	4	CID000004910
Drug	12-IODE	ALOX12B ALOX15B	7.27e-05	7	43	2	CID006450050
Drug	lupenone	ALOX12B ALOX15B	7.27e-05	7	43	2	CID000092158
Drug	dicranin	ALOX12B ALOX15B	7.27e-05	7	43	2	CID006441084
Drug	colneleic acid	ALOX12B ALOX15B	9.69e-05	8	43	2	CID006441681
Drug	Cgs 22745	ALOX12B ALOX15B	9.69e-05	8	43	2	CID006439321
Drug	htyA	ALOX12B ALOX15B	9.69e-05	8	43	2	CID000152267
Drug	CDNQ	ALOX12B ALOX15B	9.69e-05	8	43	2	CID000126468
Drug	2cgu	CYP2D7 LY75 CYP2J2	1.02e-04	48	43	3	CID003506204
Drug	14,15-leukotriene A4	ALOX12B ALOX15B	1.24e-04	9	43	2	CID006439604
Drug	octadeca-9,12-dien-1-ol	ALOX12B ALOX15B	1.24e-04	9	43	2	CID000068168
Drug	U-56467	ALOX12B ALOX15B	1.24e-04	9	43	2	CID006439532
Drug	8,15-diHPETE	ALOX12B ALOX15B	1.24e-04	9	43	2	CID005283181
Drug	13-hydroxylinoleic acid	ALOX12B ALOX15B	1.24e-04	9	43	2	CID006438633
Drug	AC1NSXHC	ALOX12B ALOX15B	1.24e-04	9	43	2	CID005371969
Drug	U-66,855	ALOX12B ALOX15B	1.24e-04	9	43	2	CID000127235
Drug	ODYA	ALOX12B ALOX15B	1.24e-04	9	43	2	CID000001931
Drug	A-78773	ALOX12B ALOX15B	1.24e-04	9	43	2	CID000071460
Drug	clotrimazole	CYP2D7 CYP2J2 ALOX12B ALOX15B	1.52e-04	143	43	4	CID000002812
Drug	9-HPODE	ALOX12B ALOX15B	1.55e-04	10	43	2	CID000001928
Drug	1,4-pentadiene	ALOX12B ALOX15B	1.55e-04	10	43	2	CID000011587
Drug	1,2-dihydroxynaphthalene	CYP2D7 CYP2J2 ALOX15B	1.71e-04	57	43	3	CID000011318
Drug	acetone phenylhydrazone	ALOX12B ALOX15B	1.90e-04	11	43	2	CID000066026
Drug	Ity A	ALOX12B ALOX15B	1.90e-04	11	43	2	CID000188274
Drug	BW A137C	ALOX12B ALOX15B	1.90e-04	11	43	2	CID000129265
Drug	mepyramine	CYP2D7 CYP2J2 ALOX12B ALOX15B	2.02e-04	154	43	4	CID000004992
Drug	12-KETE	ALOX12B ALOX15B	2.27e-04	12	43	2	CID005283162
Drug	nonenal	ALOX12B ALOX15B	2.27e-04	12	43	2	CID003015503
Drug	AC1NR1Q2	ALOX12B ALOX15B	2.68e-04	13	43	2	CID005283190
Drug	AC1L1BGZ	ALOX12B ALOX15B	2.68e-04	13	43	2	CID000001435
Drug	9-HETE	ALOX12B ALOX15B	2.68e-04	13	43	2	CID000001926
Drug	hypolaetin	ALOX12B ALOX15B	2.68e-04	13	43	2	CID005281648
Drug	ICI207968	ALOX12B ALOX15B	2.68e-04	13	43	2	CID000129095
Drug	AC1O4E1A	ALOX12B ALOX15B	2.68e-04	13	43	2	CID006365736
Drug	GBR 12909	SCNN1D CYP2D7 LOXL1	3.01e-04	69	43	3	CID000003455
Drug	isocarboxazid	TCF23 LOXL1	3.13e-04	14	43	2	CID000003759
Drug	AC1NR1LB	ALOX12B ALOX15B	3.13e-04	14	43	2	CID005283131
Drug	oxphaman	ALOX12B ALOX15B	3.13e-04	14	43	2	CID005464022
Drug	timegadine	ALOX12B ALOX15B	3.13e-04	14	43	2	CID000068902
Drug	5-HEPE	ALOX12B ALOX15B	3.13e-04	14	43	2	CID000001766
Drug	17-HdoHE	ALOX12B ALOX15B	3.13e-04	14	43	2	CID006439179
Drug	metyrapone	CYP2D7 CYP2J2 ALOX12B ALOX15B	3.59e-04	179	43	4	CID000004174
Drug	8R-HpETE	ALOX12B ALOX15B	3.60e-04	15	43	2	CID005283170
Drug	Hex-3-enyl acetate	ALOX12B ALOX15B	3.60e-04	15	43	2	CID000015574
Drug	8(S),15(S)-diHETE	ALOX12B ALOX15B	3.60e-04	15	43	2	CID000001897
Drug	13-HpOTrE	ALOX12B ALOX15B	3.60e-04	15	43	2	CID005282866
Drug	AC1L1FO5	ALOX12B ALOX15B	3.60e-04	15	43	2	CID000003322
Drug	azelastine	CYP2D7 ALOX12B ALOX15B	3.70e-04	74	43	3	CID000002267
Drug	13-HPODE	LOXL1 ALOX12B ALOX15B	3.70e-04	74	43	3	CID000001426
Drug	AC1NR1M2	ALOX12B ALOX15B	4.11e-04	16	43	2	CID005283140
Drug	12R-HETrE	ALOX12B ALOX15B	4.11e-04	16	43	2	CID005283149
Drug	peroxylinolenic acid	ALOX12B ALOX15B	4.11e-04	16	43	2	CID006439905
Drug	hex-3-enal	ALOX12B ALOX15B	4.11e-04	16	43	2	CID000023234
Drug	sinensetin	ALOX12B ALOX15B	4.11e-04	16	43	2	CID000145659
Drug	6,9,12-octadecatrienoic acid	CYP2J2 ALOX12B ALOX15B	4.32e-04	78	43	3	CID000003453
Drug	5,15-diHETE	ALOX12B ALOX15B	4.65e-04	17	43	2	CID005283158
Drug	cirsiliol	ALOX12B ALOX15B	4.65e-04	17	43	2	CID000160237
Drug	N-desisopropylpropranolol	CYP2D7 LOXL1	4.65e-04	17	43	2	CID000159899
Drug	trimipramine	CYP2D7 CYP2J2 LOXL1	4.66e-04	80	43	3	CID000005584
Drug	Etofenamate [30544-47-9]; Up 200; 10.8uM; MCF7; HT_HG-U133A	GPR137 CYLD TUT4 ACACB	4.68e-04	192	43	4	4108_UP
Drug	wortmannin; Down 200; 1uM; MCF7; HT_HG-U133A_EA	PNISR NBEAL2 U2SURP TM7SF3	4.68e-04	192	43	4	977_DN
Drug	bupropion	SCNN1D CYP2D7 LOXL1	4.83e-04	81	43	3	CID000000444
Drug	Menadione [58-27-5]; Down 200; 23.2uM; PC3; HT_HG-U133A	CYLD ACACB PNISR U2SURP	4.86e-04	194	43	4	4662_DN
Drug	Furaltadone hydrochloride [3759-92-0]; Up 200; 11uM; MCF7; HT_HG-U133A	CYLD NKX2-1 ABCA7 U2SURP	4.86e-04	194	43	4	3838_UP
Drug	17-DMAG; Down 200; 0.1uM; MCF7; HT_HG-U133A	GPR137 CYP2J2 PNISR ABCA7	4.96e-04	195	43	4	5573_DN
Drug	Cyanocobalamin [68-19-9]; Up 200; 3uM; MCF7; HT_HG-U133A	GPR137 CYLD SARDH NBEAL2	5.05e-04	196	43	4	3252_UP
Drug	Cefsulodin sodium salt [52152-93-9]; Down 200; 7.2uM; MCF7; HT_HG-U133A	GPR137 ABCA7 NBEAL2 U2SURP	5.05e-04	196	43	4	4148_DN
Drug	Aminophylline [317-34-0]; Down 200; 9.6uM; MCF7; HT_HG-U133A	GPR137 AUTS2 ABCA7 ARHGAP33	5.05e-04	196	43	4	3374_DN
Drug	Baclofen (R,S) [1134-47-0]; Up 200; 18.8uM; MCF7; HT_HG-U133A	GPR137 CYLD NBEAL2 ARHGAP33	5.05e-04	196	43	4	1536_UP
Drug	Tridihexethyl chloride; Up 200; 11.4uM; MCF7; HT_HG-U133A	CYLD ACACB PNISR ABCA7	5.05e-04	196	43	4	5486_UP
Drug	Paroxetine maleate [64006-44-6]; Down 200; 1uM; PC3; HT_HG-U133A	GPR137 ACACB PNISR U2SURP	5.15e-04	197	43	4	4556_DN
Drug	15(S)-15-methyl Prostaglandin E2; Up 200; 10uM; MCF7; HT_HG-U133A	GPR137 CYLD SARDH ARHGAP33	5.15e-04	197	43	4	7521_UP
Drug	FPL 57231	ALOX12B ALOX15B	5.23e-04	18	43	2	CID000122212
Drug	3-nonenal	ALOX12B ALOX15B	5.23e-04	18	43	2	CID005283336
Drug	BW540C	ALOX12B ALOX15B	5.23e-04	18	43	2	CID000134372
Drug	AC1O5PL5	ALOX12B ALOX15B	5.23e-04	18	43	2	CID006438380
Drug	Suramin sodium salt; Up 200; 10uM; MCF7; HT_HG-U133A	CYLD TUT4 ADAM11 ARHGAP33	5.25e-04	198	43	4	7524_UP
Drug	Carteolol hydrochloride [51781-21-6]; Up 200; 12.2uM; MCF7; HT_HG-U133A	GPR137 CYLD NBEAL2 ARHGAP33	5.25e-04	198	43	4	3276_UP
Drug	16, 16-dimethylprostaglandin E2 methyl acetate solution; Up 200; 10uM; MCF7; HT_HG-U133A	CYLD AUTS2 ACACB ARHGAP33	5.25e-04	198	43	4	6597_UP
Drug	Dihydroergocristine mesylate [24730-10-7]; Down 200; 5.6uM; PC3; HT_HG-U133A	RBM6 PNISR NBEAL2 U2SURP	5.25e-04	198	43	4	7275_DN
Drug	Alverine citrate salt [5560-59-8]; Up 200; 8.4uM; MCF7; HT_HG-U133A	GPR137 AUTS2 ADAM11 ACACB	5.25e-04	198	43	4	2273_UP
Drug	Methyldopate hydrochloride [2508-79-4]; Up 200; 14.6uM; MCF7; HT_HG-U133A	GPR137 CYLD GPNMB ARHGAP33	5.35e-04	199	43	4	4986_UP
Disease	DiGeorge syndrome (is_implicated_in)	DVL1P1 DVL1	1.88e-05	5	41	2	DOID:11198 (is_implicated_in)
Disease	thyroid gland papillary carcinoma (is_implicated_in)	MINPP1 NKX2-1	8.42e-05	10	41	2	DOID:3969 (is_implicated_in)
Disease	Pancreatic Ductal Adenocarcinoma	ADAM11 ACACB	1.03e-04	11	41	2	C1335302
Disease	microcephaly (implicated_via_orthology)	WDR81 AUTS2	9.10e-04	32	41	2	DOID:10907 (implicated_via_orthology)
Disease	joint hypermobility measurement	TUT4 LOXL1	9.68e-04	33	41	2	EFO_0007905
Disease	neurodegenerative disease (implicated_via_orthology)	SCNN1D DVL1P1 DVL1	1.08e-03	145	41	3	DOID:1289 (implicated_via_orthology)
Disease	thioredoxin domain-containing protein 12 measurement	RBM6 TUT4	1.35e-03	39	41	2	EFO_0008298
Disease	urinary albumin to creatinine ratio	WDR81 AUTS2 ARHGAP33	1.98e-03	179	41	3	EFO_0007778
Disease	lung carcinoma, estrogen-receptor negative breast cancer, ovarian endometrioid carcinoma, colorectal cancer, prostate carcinoma, ovarian serous carcinoma, breast carcinoma, ovarian carcinoma, lung adenocarcinoma, squamous cell lung carcinoma	DVL1P1 DVL1	2.39e-03	52	41	2	EFO_0000305, EFO_0000571, EFO_0000708, EFO_0001071, EFO_0001075, EFO_0001663, EFO_1000650, EFO_1001515, EFO_1001516, MONDO_0005575

Protein segments in the cluster

Peptide	Gene	Start	Entry
QLYPGTLPFPPLWPH	C6orf136	26	Q5SQH8
KNYPPGPWRLPFLGN	CYP2J2	41	P51589
FPDGKPFPHHPGWRR	GPNMB	156	Q14956
PWGAPQGPLPHLIYR	ADAM11	176	O75078
EDRGPWPLPLYPVLG	ANXA2R	31	Q3ZCQ2
PGQYGIPEPWNFPFR	ABCA7	756	Q8IZY2
PGWYGANPDPRFPAI	NKX2-1	111	P43699
PPEPYRFHPELWCSG	ITPRIP	216	Q8IWB1
APYDPRWMLAGRPHP	ACACB	2041	O00763
GPGHRHLPYWRQKGP	KRBA1	866	A5PL33
RFIHPNPGNWPPIYC	MAEL	201	Q96JY0
PYGHPFWGFLTPRQR	MYO15A	526	Q9UKN7
QDPGGRGYPLLWPAP	GPR137	391	Q96N19
HGGDPRLGWYPPYAN	LOXL1	301	Q08397
PPQHPGPYQERIWVG	C20orf203	86	Q8NBC4
PGGERFPYPSFHWDP	AUTS2	1056	Q8WXX7
PDWYNPDRAGIHGPP	LY75	801	O60449
PHWYPGHRPVRLPLW	GPR152	136	Q8TDT2
DPPRYKFPWGPRAHA	MAGEA13P	261	A6NCF6
LAHPGAWVPGPPPYL	ARHGAP33	956	O14559
PRFAALPWATNHPGP	GIG44	91	P09565
NPNRPEWNGYIPGFP	ALOX12B	171	O75342
PPGRFWHQYDLLPGP	ITIH6	936	Q6UXX5
PHPAAPWPLGQGYPY	DVL1	526	O14640
NPPFYGVIRWIGQPP	CYLD	481	Q9NQC7
PHPAAPWPLGQGYPY	DVL1P1	501	P54792
PLPRYLWPGHLSGPR	SCNN1D	11	P51172
PWAPHPLGFQGRRYI	LINC01556	31	Q5JQF7
WFQLTPPRGGHLLFP	ALOX15B	91	O15296
PPRGGHLLFPCYQWL	ALOX15B	96	O15296
RFAPGWNRDYPPPPL	RBM6	21	P78332
YEPLGLQWGLPSLPP	NBEAL2	1676	Q6ZNJ1
ERPGWFHPRGPAPVL	SARDH	506	Q9UL12
SFWRPPPLNPYLHGM	U2SURP	501	O15042
QEPPIPGWAGYLPRA	C10orf82	101	Q8WW14
HWFPGHQPELDPPRY	C11orf1	121	Q9H5F2
HQRWAARYPPGPLPL	CYP2D7	26	A0A087X1C5
LWPALYPPGRSPLHH	TNRC18	881	O15417
LPHYIPRPQGWLGVF	TRIM77	396	I1YAP6
QGLWQHYHPGLPPPD	MINPP1	196	Q9UNW1
TEWNHGLPRGFPRPP	STPG3	326	Q8N7X2
APGPPPFGLEWRRQH	TAPBP	196	O15533
PHQQRPPVYRRPGDW	TEX13A	366	Q9BXU3
AFGPPQGGFHPPYWQ	PNISR	171	Q8TF01
LPGPAWPPFLRGLRY	TCF23	136	Q7RTU1
PRPHFPLVPASWPYG	TUT4	1586	Q5TAX3
PPHPPRGVFGSWQDY	ZMYND15	451	Q9H091
GRRQGDPNYHPVLPW	WDR81	371	Q562E7
ERGRPFFPPHPYKLW	TM7SF3	506	Q9NS93