Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	nitric-oxide synthase activity	NOS1 NOS2	1.49e-05	3	45	2	GO:0004517
GeneOntologyMolecularFunction	tetrahydrobiopterin binding	NOS1 NOS2	2.97e-05	4	45	2	GO:0034617
GeneOntologyMolecularFunction	arginine binding	NOS1 NOS2	1.77e-04	9	45	2	GO:0034618
GeneOntologyMolecularFunction	FMN binding	NOS1 NOS2	5.84e-04	16	45	2	GO:0010181
GeneOntologyMolecularFunction	amino acid binding	GRIN2A NOS1 NOS2	5.96e-04	73	45	3	GO:0016597
GeneOntologyMolecularFunction	flavin adenine dinucleotide binding	SQOR NOS1 NOS2	1.24e-03	94	45	3	GO:0050660
GeneOntologyMolecularFunction	transcription factor binding	NR4A2 PRMT2 RELA DDX20 BRD8 REST PCLO	1.37e-03	753	45	7	GO:0008134
GeneOntologyMolecularFunction	RNA polymerase II core promoter sequence-specific DNA binding	RELA REST	1.44e-03	25	45	2	GO:0000979
GeneOntologyMolecularFunction	DNA-binding transcription factor binding	NR4A2 PRMT2 RELA DDX20 BRD8 REST	1.85e-03	582	45	6	GO:0140297
GeneOntologyMolecularFunction	RNA polymerase II-specific DNA-binding transcription factor binding	NR4A2 PRMT2 RELA BRD8 REST	2.38e-03	417	45	5	GO:0061629
GeneOntologyMolecularFunction	beta-catenin binding	NR4A2 PRMT2 NOS2	2.50e-03	120	45	3	GO:0008013
GeneOntologyMolecularFunction	nuclear thyroid hormone receptor binding	PRMT2 BRD8	2.66e-03	34	45	2	GO:0046966
GeneOntologyMolecularFunction	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	NOS1 NOS2	3.67e-03	40	45	2	GO:0016709
GeneOntologyBiologicalProcess	synaptic signaling	SLC17A8 DLGAP2 RELA GRIN2A LRRC4C NOS1 PTPRS SYNE1 CNTN2 PCLO BEGAIN	5.81e-06	976	45	11	GO:0099536
GeneOntologyBiologicalProcess	modulation of chemical synaptic transmission	DLGAP2 GRIN2A LRRC4C NOS1 PTPRS SYNE1 CNTN2 PCLO BEGAIN	1.09e-05	663	45	9	GO:0050804
GeneOntologyBiologicalProcess	regulation of trans-synaptic signaling	DLGAP2 GRIN2A LRRC4C NOS1 PTPRS SYNE1 CNTN2 PCLO BEGAIN	1.10e-05	664	45	9	GO:0099177
GeneOntologyBiologicalProcess	anterograde trans-synaptic signaling	SLC17A8 DLGAP2 GRIN2A LRRC4C NOS1 PTPRS SYNE1 CNTN2 PCLO BEGAIN	2.53e-05	931	45	10	GO:0098916
GeneOntologyBiologicalProcess	chemical synaptic transmission	SLC17A8 DLGAP2 GRIN2A LRRC4C NOS1 PTPRS SYNE1 CNTN2 PCLO BEGAIN	2.53e-05	931	45	10	GO:0007268
GeneOntologyBiologicalProcess	trans-synaptic signaling	SLC17A8 DLGAP2 GRIN2A LRRC4C NOS1 PTPRS SYNE1 CNTN2 PCLO BEGAIN	2.72e-05	939	45	10	GO:0099537
GeneOntologyBiologicalProcess	regulation of nervous system process	DLGAP2 GRIN2A SYNE1 PCLO BEGAIN	3.85e-05	175	45	5	GO:0031644
GeneOntologyBiologicalProcess	regulation of postsynaptic membrane potential	GRIN2A NOS1 SYNE1 PCLO BEGAIN	4.41e-05	180	45	5	GO:0060078
GeneOntologyBiologicalProcess	positive regulation of guanylate cyclase activity	NOS1 NOS2	6.94e-05	6	45	2	GO:0031284
GeneOntologyBiologicalProcess	regulation of guanylate cyclase activity	NOS1 NOS2	1.29e-04	8	45	2	GO:0031282
GeneOntologyBiologicalProcess	excitatory postsynaptic potential	GRIN2A SYNE1 PCLO BEGAIN	1.84e-04	130	45	4	GO:0060079
GeneOntologyBiologicalProcess	cell morphogenesis involved in neuron differentiation	NR4A2 LRRC4C REST WLS MAP6 PTPRS SYNE1 CNTN2	1.89e-04	748	45	8	GO:0048667
GeneOntologyBiologicalProcess	arginine catabolic process	NOS1 NOS2	2.07e-04	10	45	2	GO:0006527
GeneOntologyBiologicalProcess	chemical synaptic transmission, postsynaptic	GRIN2A SYNE1 PCLO BEGAIN	2.94e-04	147	45	4	GO:0099565
GeneOntologyBiologicalProcess	neuron projection morphogenesis	NR4A2 LRRC4C WLS ATXN2 MAP6 PTPRS SYNE1 CNTN2	3.03e-04	802	45	8	GO:0048812
GeneOntologyBiologicalProcess	plasma membrane bounded cell projection morphogenesis	NR4A2 LRRC4C WLS ATXN2 MAP6 PTPRS SYNE1 CNTN2	3.49e-04	819	45	8	GO:0120039
GeneOntologyBiologicalProcess	defense response to tumor cell	RELA RBMS3	3.58e-04	13	45	2	GO:0002357
GeneOntologyBiologicalProcess	cell projection morphogenesis	NR4A2 LRRC4C WLS ATXN2 MAP6 PTPRS SYNE1 CNTN2	3.70e-04	826	45	8	GO:0048858
GeneOntologyBiologicalProcess	modulation of excitatory postsynaptic potential	GRIN2A SYNE1 PCLO	3.86e-04	65	45	3	GO:0098815
GeneOntologyBiologicalProcess	peptidyl-cysteine S-nitrosylation	NOS1 NOS2	6.20e-04	17	45	2	GO:0018119
GeneOntologyBiologicalProcess	regulation of postsynaptic neurotransmitter receptor activity	DLGAP2 BEGAIN	6.20e-04	17	45	2	GO:0098962
GeneOntologyCellularComponent	somatodendritic compartment	SLC17A8 DLGAP2 GRIN2A WLS MAP6 NOS1 PTPRS SYNE1 CNTN2 PCLO BEGAIN	4.38e-05	1228	45	11	GO:0036477
GeneOntologyCellularComponent	glutamatergic synapse	SLC17A8 DLGAP2 RELA GRIN2A LRRC4C NOS1 PTPRS PCLO BEGAIN	5.09e-05	817	45	9	GO:0098978
GeneOntologyCellularComponent	dendrite	SLC17A8 DLGAP2 GRIN2A WLS MAP6 NOS1 SYNE1 PCLO BEGAIN	7.42e-05	858	45	9	GO:0030425
GeneOntologyCellularComponent	dendritic tree	SLC17A8 DLGAP2 GRIN2A WLS MAP6 NOS1 SYNE1 PCLO BEGAIN	7.56e-05	860	45	9	GO:0097447
GeneOntologyCellularComponent	postsynaptic density, intracellular component	DLGAP2 GRIN2A NOS1	1.60e-04	49	45	3	GO:0099092
GeneOntologyCellularComponent	postsynaptic specialization, intracellular component	DLGAP2 GRIN2A NOS1	2.39e-04	56	45	3	GO:0099091
GeneOntologyCellularComponent	postsynapse	DLGAP2 GRIN2A LRRC4C NOS1 PTPRS SYNE1 CNTN2 PCLO BEGAIN	2.70e-04	1018	45	9	GO:0098794
GeneOntologyCellularComponent	postsynaptic density	DLGAP2 GRIN2A LRRC4C NOS1 PTPRS PCLO	3.90e-04	451	45	6	GO:0014069
GeneOntologyCellularComponent	asymmetric synapse	DLGAP2 GRIN2A LRRC4C NOS1 PTPRS PCLO	5.24e-04	477	45	6	GO:0032279
GeneOntologyCellularComponent	postsynaptic specialization	DLGAP2 GRIN2A LRRC4C NOS1 PTPRS PCLO	6.92e-04	503	45	6	GO:0099572
GeneOntologyCellularComponent	perinuclear region of cytoplasm	PTGES RNF128 ATXN2 MAP6 NOS1 NOS2 SYNE1 PCLO	7.63e-04	934	45	8	GO:0048471
GeneOntologyCellularComponent	neuron to neuron synapse	DLGAP2 GRIN2A LRRC4C NOS1 PTPRS PCLO	8.48e-04	523	45	6	GO:0098984
GeneOntologyCellularComponent	axon terminus	SLC17A8 GRIN2A NOS1 PCLO	1.07e-03	210	45	4	GO:0043679
GeneOntologyCellularComponent	neuron projection terminus	SLC17A8 GRIN2A NOS1 PCLO	1.57e-03	233	45	4	GO:0044306
GeneOntologyCellularComponent	excitatory synapse	SLC17A8 GRIN2A PCLO	1.58e-03	107	45	3	GO:0060076
GeneOntologyCellularComponent	postsynaptic membrane	GRIN2A LRRC4C PTPRS SYNE1 CNTN2	1.72e-03	405	45	5	GO:0045211
GeneOntologyCellularComponent	dendritic spine	DLGAP2 GRIN2A NOS1 SYNE1	1.80e-03	242	45	4	GO:0043197
GeneOntologyCellularComponent	neuron spine	DLGAP2 GRIN2A NOS1 SYNE1	1.94e-03	247	45	4	GO:0044309
GeneOntologyCellularComponent	distal axon	SLC17A8 GRIN2A NOS1 PTPRS PCLO	2.35e-03	435	45	5	GO:0150034
GeneOntologyCellularComponent	axon	SLC17A8 GRIN2A MAP6 NOS1 PTPRS CNTN2 PCLO	2.75e-03	891	45	7	GO:0030424
GeneOntologyCellularComponent	parallel fiber to Purkinje cell synapse	GRIN2A PCLO	3.87e-03	43	45	2	GO:0098688
GeneOntologyCellularComponent	postsynaptic density membrane	GRIN2A LRRC4C PTPRS	4.68e-03	157	45	3	GO:0098839
GeneOntologyCellularComponent	microbody lumen	ACOT8 NOS2	6.26e-03	55	45	2	GO:0031907
GeneOntologyCellularComponent	peroxisomal matrix	ACOT8 NOS2	6.26e-03	55	45	2	GO:0005782
GeneOntologyCellularComponent	dendrite membrane	GRIN2A WLS	6.48e-03	56	45	2	GO:0032590
MousePheno	abnormal behavioral response to xenobiotic	NR4A2 SLC17A8 ADAMTS4 MAP6 NOS1 NOS2 CNTN2	1.69e-05	309	38	7	MP:0009745
MousePheno	abnormal nervous system regeneration	NOS1 PTPRS NOS2	2.38e-05	21	38	3	MP:0004858
MousePheno	delayed peripheral nervous system regeneration	NOS1 NOS2	4.30e-05	4	38	2	MP:0031330
MousePheno	enhanced central nervous system regeneration	PTPRS NOS2	1.07e-04	6	38	2	MP:0030013
MousePheno	abnormal behavioral response to addictive substance	NR4A2 SLC17A8 MAP6 NOS1	1.63e-04	102	38	4	MP:0009748
MousePheno	decreased synaptic glutamate release	SLC17A8 NOS1	1.99e-04	8	38	2	MP:0004495
MousePheno	abnormal seizure response to inducing agent	GRIN2A ADAMTS4 NOS1 NOS2 CNTN2	2.00e-04	201	38	5	MP:0009357
MousePheno	enhanced behavioral response to addictive substance	NR4A2 SLC17A8 NOS1	2.27e-04	44	38	3	MP:0009749
MousePheno	decreased susceptibility to induced choroidal neovascularization	NOS1 NOS2	3.19e-04	10	38	2	MP:0003434
MousePheno	seizures	SLC17A8 GRIN2A ADAMTS4 NOS1 NOS2 CNTN2	3.85e-04	360	38	6	MP:0002064
MousePheno	abnormal peripheral nervous system regeneration	NOS1 NOS2	3.90e-04	11	38	2	MP:0004220
MousePheno	abnormal central nervous system regeneration	PTPRS NOS2	3.90e-04	11	38	2	MP:0003407
Domain	-	NOS1 NOS2	1.62e-05	3	44	2	3.90.340.10
Domain	NOS_N	NOS1 NOS2	1.62e-05	3	44	2	IPR004030
Domain	NOS	NOS1 NOS2	1.62e-05	3	44	2	PS60001
Domain	NO_synthase	NOS1 NOS2	1.62e-05	3	44	2	PF02898
Domain	NOS_euk	NOS1 NOS2	1.62e-05	3	44	2	IPR012144
Domain	-	NOS1 NOS2	8.09e-05	6	44	2	1.20.990.10
Domain	NADPH_Cyt_P450_Rdtase_dom3	NOS1 NOS2	8.09e-05	6	44	2	IPR023173
Domain	FAD_binding_1	NOS1 NOS2	8.09e-05	6	44	2	PF00667
Domain	FAD-binding_1	NOS1 NOS2	8.09e-05	6	44	2	IPR003097
Domain	Flavdoxin-like	NOS1 NOS2	1.51e-04	8	44	2	IPR001094
Domain	FLAVODOXIN_LIKE	NOS1 NOS2	1.51e-04	8	44	2	PS50902
Domain	Flavodoxin_1	NOS1 NOS2	1.51e-04	8	44	2	PF00258
Domain	Flavodoxin/NO_synth	NOS1 NOS2	1.51e-04	8	44	2	IPR008254
Domain	Flavoprotein-like_dom	NOS1 NOS2	2.41e-04	10	44	2	IPR029039
Domain	Flavoprot_Pyr_Nucl_cyt_Rdtase	NOS1 NOS2	2.41e-04	10	44	2	IPR001709
Domain	-	NOS1 NOS2	2.41e-04	10	44	2	3.40.50.360
Domain	OxRdtase_FAD/NAD-bd	NOS1 NOS2	3.53e-04	12	44	2	IPR001433
Domain	NAD_binding_1	NOS1 NOS2	3.53e-04	12	44	2	PF00175
Domain	Fd_Rdtase_FAD-bd	NOS1 NOS2	9.04e-04	19	44	2	IPR017927
Domain	FAD_FR	NOS1 NOS2	9.04e-04	19	44	2	PS51384
Domain	Riboflavin_synthase-like_b-brl	NOS1 NOS2	9.04e-04	19	44	2	IPR017938
Domain	PDZ	ARHGEF12 NOS1 PCLO	5.38e-03	151	44	3	PS50106
Domain	PDZ	ARHGEF12 NOS1 PCLO	5.48e-03	152	44	3	IPR001478
Domain	Ig_I-set	LRRC4C PTPRS CNTN2	1.01e-02	190	44	3	IPR013098
Domain	I-set	LRRC4C PTPRS CNTN2	1.01e-02	190	44	3	PF07679
Pathway	WP_NITRIC_OXIDE_METABOLISM_IN_CYSTIC_FIBROSIS	PRMT2 NOS1 NOS2	2.45e-06	13	30	3	M39894
Pathway	WP_NOCGMPPKG_MEDIATED_NEUROPROTECTION	RELA GRIN2A NOS1 NOS2	2.79e-06	47	30	4	M39531
Pathway	REACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES	DLGAP2 GRIN2A PTPRS BEGAIN	3.28e-05	87	30	4	M27617
Pathway	WP_EFFECTS_OF_NITRIC_OXIDE	NOS1 NOS2	1.22e-04	8	30	2	M39677
Pathway	REACTOME_NEUREXINS_AND_NEUROLIGINS	DLGAP2 GRIN2A BEGAIN	2.23e-04	56	30	3	M27616
Pathway	WP_NEUROINFLAMMATION	RELA NOS2	3.37e-04	13	30	2	M39895
Pathway	REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE	NOS1 NOS2	3.37e-04	13	30	2	MM15015
Pathway	REACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES	DLGAP2 GRIN2A PTPRS	3.80e-04	67	30	3	MM15327
Pathway	WP_RAC1PAK1P38MMP2_PATHWAY	RELA NOS1 NOS2	3.97e-04	68	30	3	M39456
Pathway	KEGG_MEDICUS_REFERENCE_AGE_RAGE_SIGNALING_PATHWAY	RELA NOS2	5.16e-04	16	30	2	M47682
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_AGE_RAGE_SIGNALING_PATHWAY	RELA NOS2	5.84e-04	17	30	2	M47684
Pathway	BIOCARTA_NOS1_PATHWAY	GRIN2A NOS1	8.12e-04	20	30	2	MM1445
Pathway	REACTOME_SYNAPTIC_ADHESION_LIKE_MOLECULES	GRIN2A PTPRS	8.12e-04	20	30	2	MM15485
Pathway	REACTOME_SYNAPTIC_ADHESION_LIKE_MOLECULES	GRIN2A PTPRS	8.97e-04	21	30	2	M27736
Pathway	BIOCARTA_NOS1_PATHWAY	GRIN2A NOS1	8.97e-04	21	30	2	M11650
Pathway	WP_ADHD_AND_AUTISM_ASD_PATHWAYS	DLGAP2 GRIN2A NOS1 NOS2 CNTN2	9.70e-04	367	30	5	M48346
Pathway	REACTOME_NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE	NOS1 NOS2	9.85e-04	22	30	2	M915
Pathway	WP_SILDENAFIL_TREATMENT	NOS1 NOS2	1.08e-03	23	30	2	M46455
Pathway	WP_UREA_CYCLE_AND_ASSOCIATED_PATHWAYS	NOS1 NOS2	1.17e-03	24	30	2	M39850
Pubmed	[Association of Inorganics Accumulation with the Activation of NF-κB Signaling Pathway and the iNOS Expression of Lung Tissue in Xuanwei Lung Cancer Patients].	RELA NOS2	1.71e-06	2	46	2	26805735
Pubmed	Shunting of prostanoid biosynthesis in microsomal prostaglandin E synthase-1 null embryo fibroblasts: regulatory effects on inducible nitric oxide synthase expression and nitrite synthesis.	PTGES NOS2	1.71e-06	2	46	2	17023389
Pubmed	Roles of iNOS and nNOS in sepsis-induced pulmonary apoptosis.	NOS1 NOS2	1.71e-06	2	46	2	14660484
Pubmed	Role of inducible or neuronal nitric oxide synthase in neurogenesis of the dentate gyrus in aged mice.	NOS1 NOS2	1.71e-06	2	46	2	21082337
Pubmed	Daedalea gibbosa substances inhibit LPS-induced expression of iNOS by suppression of NF-kappaB and MAPK activities in RAW 264.7 macrophage cells.	RELA NOS2	1.71e-06	2	46	2	20127048
Pubmed	Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.	NOS1 NOS2	1.71e-06	2	46	2	7682706
Pubmed	Pyroptotic and apoptotic cell death in iNOS and nNOS overexpressing K562 cells: A mechanistic insight.	NOS1 NOS2	1.71e-06	2	46	2	31881190
Pubmed	Inducible nitric oxide synthase is involved in acid-induced gastric hyperemia in rats and mice.	NOS1 NOS2	1.71e-06	2	46	2	12646421
Pubmed	The role of nitric oxide synthases in the sleep responses to tumor necrosis factor-alpha.	NOS1 NOS2	1.71e-06	2	46	2	15157956
Pubmed	Effects of ethanol on neutrophil recruitment and lung host defense in nitric oxide synthase I and nitric oxide synthase II knockout mice.	NOS1 NOS2	1.71e-06	2	46	2	10512307
Pubmed	[Expression of cell adhesion molecule and nitric oxide synthase in nasal mucosa in allergic rhinitis].	NOS1 NOS2	1.71e-06	2	46	2	16780147
Pubmed	Expression of inducible nitric oxide synthase in the liver is under the control of nuclear factor kappa B in concanavalin A-induced hepatitis.	RELA NOS2	1.71e-06	2	46	2	17683476
Pubmed	Advanced glycosylation end products induce NF-kappaB dependent iNOS expression in RAW 264.7 cells.	RELA NOS2	1.71e-06	2	46	2	12242023
Pubmed	Inducible-NOS but not neuronal-NOS participate in the acute effect of TNF-alpha on hypothalamic insulin-dependent inhibition of food intake.	NOS1 NOS2	1.71e-06	2	46	2	16876161
Pubmed	NOS2 regulation of NF-kappaB by S-nitrosylation of p65.	RELA NOS2	1.71e-06	2	46	2	17720813
Pubmed	Chronic alcohol consumption induces an overproduction of NO by nNOS- and iNOS-expressing myenteric neurons in the murine small intestine.	NOS1 NOS2	1.71e-06	2	46	2	21470341
Pubmed	Role of nitric oxide synthase in the development of bone cancer pain and effect of L-NMMA.	NOS1 NOS2	1.71e-06	2	46	2	26648027
Pubmed	Nitric oxide synthases: roles, tolls, and controls.	NOS1 NOS2	1.71e-06	2	46	2	7522969
Pubmed	Contribution of inducible and neuronal nitric oxide synthases to mitochondrial damage and melatonin rescue in LPS-treated mice.	NOS1 NOS2	1.71e-06	2	46	2	28110436
Pubmed	Influenza virus-induced sleep responses in mice with targeted disruptions in neuronal or inducible nitric oxide synthases.	NOS1 NOS2	1.71e-06	2	46	2	15220315
Pubmed	Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme.	NOS1 NOS2	1.71e-06	2	46	2	1379716
Pubmed	Protein nitration promotes inducible nitric oxide synthase transcription mediated by NF-κB in high glucose-stimulated human lens epithelial cells.	RELA NOS2	1.71e-06	2	46	2	23454417
Pubmed	A conserved Val to Ile switch near the heme pocket of animal and bacterial nitric-oxide synthases helps determine their distinct catalytic profiles.	NOS1 NOS2	1.71e-06	2	46	2	14976216
Pubmed	Family-based association study between NOS-I and -IIA polymorphisms and autism spectrum disorders in Korean trios.	NOS1 NOS2	1.71e-06	2	46	2	18563708
Pubmed	Role of different nitric oxide synthase isoforms in a murine model of acute lung injury and sepsis.	NOS1 NOS2	1.71e-06	2	46	2	20655878
Pubmed	Ligustilide prevents LPS-induced iNOS expression in RAW 264.7 macrophages by preventing ROS production and down-regulating the MAPK, NF-κB and AP-1 signaling pathways.	RELA NOS2	1.71e-06	2	46	2	21457761
Pubmed	The spinal cord expression of neuronal and inducible nitric oxide synthases and their contribution in the maintenance of neuropathic pain in mice.	NOS1 NOS2	1.71e-06	2	46	2	21179208
Pubmed	Spontaneous sleep in mice with targeted disruptions of neuronal or inducible nitric oxide synthase genes.	NOS1 NOS2	1.71e-06	2	46	2	12738065
Pubmed	Deficiency of iNOS does not attenuate severe congestive heart failure in mice.	NOS1 NOS2	1.71e-06	2	46	2	15319210
Pubmed	Association between inducible and neuronal nitric oxide synthase polymorphisms and recurrent depressive disorder.	NOS1 NOS2	1.71e-06	2	46	2	20888049
Pubmed	Role of Nitric Oxide in Stress-Induced Anxiety: From Pathophysiology to Therapeutic Target.	NOS1 NOS2	1.71e-06	2	46	2	28061969
Pubmed	Mechanistic studies on the intramolecular one-electron transfer between the two flavins in the human neuronal nitric-oxide synthase and inducible nitric-oxide synthase flavin domains.	NOS1 NOS2	1.71e-06	2	46	2	12777376
Pubmed	Inducible nitric oxide synthase stimulates dopaminergic neurodegeneration in the MPTP model of Parkinson disease.	NOS1 NOS2	1.71e-06	2	46	2	10581083
Pubmed	Functional variants in NOS1 and NOS2A are not associated with progressive hearing loss in Ménière's disease in a European Caucasian population.	NOS1 NOS2	1.71e-06	2	46	2	21612410
Pubmed	Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line.	NOS1 NOS2	1.71e-06	2	46	2	1372907
Pubmed	Polymorphisms of the neuronal and inducible nitric oxide synthase genes and the risk of cutaneous melanoma: a case-control study.	NOS1 NOS2	1.71e-06	2	46	2	17328085
Pubmed	Mitochondrial impairment and melatonin protection in parkinsonian mice do not depend of inducible or neuronal nitric oxide synthases.	NOS1 NOS2	1.71e-06	2	46	2	28800639
Pubmed	Association between Parkinson's disease and polymorphisms in the nNOS and iNOS genes in a community-based case-control study.	NOS1 NOS2	1.71e-06	2	46	2	12490535
Pubmed	Suppression of NF-κB by dieckol extracted from Ecklonia cava negatively regulates LPS induction of inducible nitric oxide synthase gene.	RELA NOS2	1.71e-06	2	46	2	24744158
Pubmed	Increased nitric oxide caused by the ketogenic diet reduces the onset time of kainic acid-induced seizures in ICR mice.	NOS1 NOS2	1.71e-06	2	46	2	16460714
Pubmed	Ferrous citrate up-regulates the NOS2 through nuclear translocation of NFκB induced by free radicals generation in mouse cerebral endothelial cells.	RELA NOS2	1.71e-06	2	46	2	23029446
Pubmed	Intra- and inter-molecular effects of a conserved arginine residue of neuronal and inducible nitric oxide synthases on FMN and calmodulin binding.	NOS1 NOS2	1.71e-06	2	46	2	23507581
Pubmed	Nitric oxide mediates selective degeneration of hypothalamic orexin neurons through dysfunction of protein disulfide isomerase.	NOS1 NOS2	1.71e-06	2	46	2	23904594
Pubmed	LUBAC assembles a ubiquitin signaling platform at mitochondria for signal amplification and transport of NF-κB to the nucleus.	RELA DDX20 ACOT8 SQOR	1.82e-06	66	46	4	36398858
Pubmed	Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.	DLGAP2 GRIN2A MAP6 SYNE1 PCLO BEGAIN	1.88e-06	281	46	6	28706196
Pubmed	Reduced expression of neuropeptide genes in a genome-wide screen of a secretion-deficient mouse.	GRIN2A NOS1 CNTN2 PCLO	1.93e-06	67	46	4	16987237
Pubmed	Identification of genetic factors associated with susceptibility to angiotensin-converting enzyme inhibitors-induced cough.	PTGES NOS1 NOS2	2.07e-06	19	46	3	21052031
Pubmed	The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord.	NOS1 NOS2 CNTN2	3.76e-06	23	46	3	17954614
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	ARHGEF12 DLGAP2 GRIN2A ATXN2 MAP6 NOS1 PTPRS SYNE1 BEGAIN	4.05e-06	963	46	9	28671696
Pubmed	Human immunodeficiency virus-1-infected macrophages induce inducible nitric oxide synthase and nitric oxide (NO) production in astrocytes: astrocytic NO as a possible mediator of neural damage in acquired immunodeficiency syndrome.	NOS1 NOS2	5.13e-06	3	46	2	10068656
Pubmed	Molecular architecture of mammalian nitric oxide synthases.	NOS1 NOS2	5.13e-06	3	46	2	25125509
Pubmed	The gastric mucus layers: constituents and regulation of accumulation.	NOS1 NOS2	5.13e-06	3	46	2	18719000
Pubmed	Nitric oxide synthase isoforms and NF-kappaB activity in normal and osteoarthritic human chondrocytes: regulation by inducible nitric oxide.	NOS1 NOS2	5.13e-06	3	46	2	18675932
Pubmed	Relative contributions of endothelial, inducible, and neuronal NOS to tone in the murine pulmonary circulation.	NOS1 NOS2	5.13e-06	3	46	2	10484454
Pubmed	Human T-cell leukemia virus type 1 bZIP factor selectively suppresses the classical pathway of NF-kappaB.	RELA CNTN2	5.13e-06	3	46	2	19064727
Pubmed	Reductase domain cysteines 1048 and 1114 are critical for catalytic activity of human endothelial cell nitric oxide synthase as probed by site-directed mutagenesis.	NOS1 NOS2	5.13e-06	3	46	2	8806629
Pubmed	Crucial roles of nitric oxide synthases in β-adrenoceptor-mediated bladder relaxation in mice.	NOS1 NOS2	5.13e-06	3	46	2	27784691
Pubmed	Differential regulation of neuronal and inducible nitric oxide synthase (NOS) in the spinal cord of mutant SOD1 (G93A) ALS mice.	NOS1 NOS2	5.13e-06	3	46	2	19580782
Pubmed	Role of NO synthase in the development of Trypanosoma cruzi-induced cardiomyopathy in mice.	NOS1 NOS2	5.13e-06	3	46	2	19407124
Pubmed	Nitric oxide synthase gene knockout mice do not become hypertensive during pregnancy.	NOS1 NOS2	5.13e-06	3	46	2	11717657
Pubmed	Estrogen induces nitric oxide production via activation of constitutive nitric oxide synthases in human neuroblastoma cells.	NOS1 NOS2	5.13e-06	3	46	2	15242984
Pubmed	Secretagogue-stimulated pancreatic secretion is differentially regulated by constitutive NOS isoforms in mice.	NOS1 NOS2	5.13e-06	3	46	2	14551061
Pubmed	Nitric oxide synthases and heart failure - lessons from genetically manipulated mice.	NOS1 NOS2	5.13e-06	3	46	2	23774658
Pubmed	Human immunodeficiency virus infection, inducible nitric oxide synthase expression, and microglial activation: pathogenetic relationship to the acquired immunodeficiency syndrome dementia complex.	NOS1 NOS2	5.13e-06	3	46	2	10443886
Pubmed	Mechanisms and structural determinants of HIV-1 coat protein, gp41-induced neurotoxicity.	NOS1 NOS2	5.13e-06	3	46	2	9870939
Pubmed	Severe dyslipidaemia, atherosclerosis, and sudden cardiac death in mice lacking all NO synthases fed a high-fat diet.	NOS1 NOS2	5.13e-06	3	46	2	20304785
Pubmed	Paradoxical roles of different nitric oxide synthase isoforms in colonic injury.	NOS1 NOS2	5.13e-06	3	46	2	14665440
Pubmed	Nitric oxide synthase polymorphisms, gene expression and lung function in chronic obstructive pulmonary disease.	NOS1 NOS2	5.13e-06	3	46	2	24192154
Pubmed	Deletion of neuronal NOS prevents impaired vasodilation in septic mouse skeletal muscle.	NOS1 NOS2	5.13e-06	3	46	2	17258180
Pubmed	The Functional Diversity of Nitric Oxide Synthase Isoforms in Human Nose and Paranasal Sinuses: Contrasting Pathophysiological Aspects in Nasal Allergy and Chronic Rhinosinusitis.	NOS1 NOS2	5.13e-06	3	46	2	34299181
Pubmed	Brainstem prolactin mRNA is enhanced in mice with suppressed neuronal nitric oxide synthase activity.	NOS1 NOS2	5.13e-06	3	46	2	15469894
Pubmed	Obesity, insulin resistance, and skeletal muscle nitric oxide synthase.	NOS1 NOS2	5.13e-06	3	46	2	22797309
Pubmed	Thrombin induces inducible nitric oxide synthase expression via the MAPK, MSK1, and NF-κB signaling pathways in alveolar macrophages.	RELA NOS2	5.13e-06	3	46	2	22004609
Pubmed	Signal pathways coupled to activation of neuronal nitric oxide synthase in the spinal cord by nociceptin/orphanin FQ.	GRIN2A NOS1	5.13e-06	3	46	2	17350656
Pubmed	NOS1-derived nitric oxide promotes NF-κB transcriptional activity through inhibition of suppressor of cytokine signaling-1.	RELA NOS1	5.13e-06	3	46	2	26324446
Pubmed	Association between achalasia and nitric oxide synthase gene polymorphisms.	NOS1 NOS2	5.13e-06	3	46	2	16848803
Pubmed	Nitric oxide synthases: which, where, how, and why?	NOS1 NOS2	5.13e-06	3	46	2	9410890
Pubmed	Cellular and molecular mechanisms of endothelial cell dysfunction.	NOS1 NOS2	5.13e-06	3	46	2	9410891
Pubmed	Nitric oxide synthase gene polymorphisms in functional dyspepsia.	NOS1 NOS2	5.13e-06	3	46	2	24114042
Pubmed	Lessons from genetically engineered animal models. IV. Nitric oxide synthase gene knockout mice.	NOS1 NOS2	5.13e-06	3	46	2	10516139
Pubmed	Relaxation of myometrium by calcitonin gene-related peptide is independent of nitric oxide synthase activity in mouse uterus.	NOS1 NOS2	5.13e-06	3	46	2	11058547
Pubmed	Leukocyte-endothelial cell interactions in nitric oxide synthase-deficient mice.	NOS1 NOS2	5.13e-06	3	46	2	10362674
Pubmed	[Polymorphic markers of the NO synthase genes and genetic predisposition to diabetic polyneuropathy in patients with type 1 diabetes mellitus].	NOS1 NOS2	5.13e-06	3	46	2	15856945
Pubmed	Genetic disruption of all NO synthase isoforms enhances BMD and bone turnover in mice in vivo: involvement of the renin-angiotensin system.	NOS1 NOS2	5.13e-06	3	46	2	18433298
Pubmed	Defective fluid and HCO(3)(-) absorption in proximal tubule of neuronal nitric oxide synthase-knockout mice.	NOS1 NOS2	5.13e-06	3	46	2	10966931
Pubmed	Substance P enhances wound closure in nitric oxide synthase knockout mice.	NOS1 NOS2	5.13e-06	3	46	2	18952239
Pubmed	Metabolic profile and nitric oxide synthase expression of skeletal muscle fibers are altered in patients with type 1 diabetes.	NOS1 NOS2	5.13e-06	3	46	2	18465682
Pubmed	Ultrasound stimulates NF-kappaB activation and iNOS expression via the Ras/Raf/MEK/ERK signaling pathway in cultured preosteoblasts.	RELA NOS2	5.13e-06	3	46	2	19288477
Pubmed	Autoregulation of nitric oxide-soluble guanylate cyclase-cyclic GMP signalling in mouse thoracic aorta.	NOS1 NOS2	5.13e-06	3	46	2	10556946
Pubmed	Subunit interactions of endothelial nitric-oxide synthase. Comparisons to the neuronal and inducible nitric-oxide synthase isoforms.	NOS1 NOS2	5.13e-06	3	46	2	8995432
Pubmed	nNOS deficiency-induced cell proliferation depletes the neurogenic reserve.	NOS1 NOS2	5.13e-06	3	46	2	22027181
Pubmed	Nitric oxide synthase isoforms undertake unique roles during excitotoxicity.	NOS1 NOS2	5.13e-06	3	46	2	17446423
Pubmed	Role of nitric oxide synthase isoforms for ophthalmic artery reactivity in mice.	NOS1 NOS2	5.13e-06	3	46	2	25017185
Pubmed	Nitric oxide synthase enzymes in the airways of mice exposed to ovalbumin: NOS2 expression is NOS3 dependent.	NOS1 NOS2	5.13e-06	3	46	2	20953358
Pubmed	Nitric oxide synthases and protein oxidation in the quadriceps femoris of patients with chronic obstructive pulmonary disease.	NOS1 NOS2	5.13e-06	3	46	2	12816735
Pubmed	Functional consequences of the collagen/elastin switch in vascular remodeling in hyperhomocysteinemic wild-type, eNOS-/-, and iNOS-/- mice.	NOS1 NOS2	5.13e-06	3	46	2	20581102
Pubmed	Heterologous down-regulation of angiotensin type 1 receptors by purinergic P2Y2 receptor stimulation through S-nitrosylation of NF-kappaB.	RELA NOS2	5.13e-06	3	46	2	21464294
Pubmed	Linking of mPGES-1 and iNOS activates stem-like phenotype in EGFR-driven epithelial tumor cells.	PTGES NOS2	5.13e-06	3	46	2	28257996
Pubmed	Pulmonary nitric oxide synthases and nitrotyrosine: findings during lung development and in chronic lung disease of prematurity.	NOS1 NOS2	5.13e-06	3	46	2	16950998
Pubmed	Expression profiles of NOS isoforms in gingiva of nNOS knockout mice.	NOS1 NOS2	5.13e-06	3	46	2	24657074
Cytoband	20q13.12	ACOT8 PCIF1	1.68e-03	60	46	2	20q13.12
GeneFamily	PDZ domain containing	ARHGEF12 NOS1 PCLO	1.31e-03	152	26	3	1220
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	LRRC4C PTPRS CNTN2	1.55e-03	161	26	3	593
Coexpression	GSE3982_DC_VS_BASOPHIL_DN	SELPLG PRMT2 BRD8 SYNE1 BEGAIN	2.05e-05	199	44	5	M5473
Coexpression	GSE5589_IL6_KO_VS_IL10_KO_LPS_STIM_MACROPHAGE_180MIN_UP	PUDP ADAMTS4 ABHD18 MAP6 PTPRS	2.10e-05	200	44	5	M6664
Coexpression	ANDERSON_BLOOD_CN54GP140_ADJUVANTED_WITH_GLA_AF_AGE_18_45YO_3DY_DN	ZAN WLS RAI2	2.55e-05	34	44	3	M40965
ToppCell	RA-14._Fibroblast_III\|World / Chamber and Cluster_Paper	NR4A2 BNC2 ADAMTS4 RBMS3 PTPRS	1.48e-06	189	46	5	b6e12d24d2b0735730bdc625f8318c1c9c2a9b3b
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_2_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	BNC2 ADAMTS4 RBMS3 PTPRS RAI2	1.64e-06	193	46	5	261cafc167c86ab277be4ea7f08b0173e2dde26e
ToppCell	3'-Broncho-tracheal-Immune_Lymphocytic-Lymphocytic_T/NK-natural_killer_cell-NK_cells-\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	NR4A2 BRD8 MAP6 SYNE1	3.18e-05	175	46	4	26bd957498e41a3f1ffa60d3effa27ca8c4ba631
ToppCell	TCGA-Ovary-Primary_Tumor-Ovarian_Carcinoma-Serous_Cystadenocarcinoma-6\|TCGA-Ovary / Sample_Type by Project: Shred V9	RFX8 ADAMTS4 OLFML2B SYNE1	3.39e-05	178	46	4	142879e9393e721f9b05a6bb46995c9d6d713c95
ToppCell	COVID-19-kidney-Epi_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	BNC2 RBMS3 OLFML2B SYNE1	3.47e-05	179	46	4	e7c9dc63f03d3f3746b51a7e3c8393089e2ceb7d
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_B-Branch_B1_(eMN)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BNC2 MAP6 PTPRS PCLO	3.62e-05	181	46	4	7f99002a6411117cc2361334c7c9228e20c574b4
ToppCell	NS-moderate-d_16-33-Lymphoid-NK\|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	BNC2 ADAMTS4 NOS1 BEGAIN	3.70e-05	182	46	4	fb503f8ecd013f1f2161a5841572b57cfcddb6fa
ToppCell	AT1-AT2_cells-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	IQCN RBMS3 PCLO RAI2	3.78e-05	183	46	4	6821dca076318115d360ff426eb1218cfe104063
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC4C ZAN CNTN2 PCLO	3.86e-05	184	46	4	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC4C ZAN CNTN2 PCLO	3.86e-05	184	46	4	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC4C ZAN CNTN2 PCLO	3.86e-05	184	46	4	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L2-4_SST_AHR\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	CCNJL WLS RBMS3 NOS1	3.86e-05	184	46	4	1158a55c1990fd23d270cb6510d0951c4bfcddc5
ToppCell	Fetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DLGAP2 FAM153B MAP6 PCLO	4.20e-05	188	46	4	c4c3b21ab723b0e9beff9ec84f8d68485f771528
ToppCell	Smart-seq2-blood_(Smart-seq2)-lymphocytic-innate_lymphocytic\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CCNJL SELPLG BNC2 SYNE1	4.38e-05	190	46	4	1f890be1ac8613a098b271945f25a58c3c2530ab
ToppCell	Smart-seq2-blood_(Smart-seq2)-lymphocytic-innate_lymphocytic-mature_NK_T_cell\|blood_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	CCNJL SELPLG BNC2 SYNE1	4.38e-05	190	46	4	d7cecf88451f736f8f3f6f4644504cf22846cd6e
ToppCell	Children_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)\|Children_(3_yrs) / Lineage, Cell type, age group and donor	ARHGEF12 GRIN2A NOS2 SYNE1	4.47e-05	191	46	4	f229abf69a1217194f74b0502486907e07dba989
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC17A8 WLS RBMS3 NOS1	4.56e-05	192	46	4	dc40ef2341e5d6a6d479f140e023fe1bf687928d
ToppCell	facs-Aorta-Heart-3m-Mesenchymal\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WLS RBMS3 PTPRS OLFML2B	4.56e-05	192	46	4	0dc1f46e40346ed0b286e53b106a812441575100
ToppCell	droplet-Lung-1m-Mesenchymal-myofibroblast\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	LRRC4C MAP6 RBMS3 OLFML2B	4.56e-05	192	46	4	dc4b4e16e6eb212e45fb70695afd1c7e91027407
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC17A8 WLS RBMS3 NOS1	4.65e-05	193	46	4	d1445b8bf2bab36e1a326ddb2a528151db016c7d
ToppCell	LA-14._Fibroblast_III\|LA / Chamber and Cluster_Paper	NR4A2 BNC2 ADAMTS4 RBMS3	4.65e-05	193	46	4	7426c291bac59e539c427bcaae18abc7d397d44e
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC17A8 WLS RBMS3 NOS1	4.65e-05	193	46	4	010717ca052b6c8a525a43aaeffddea0d1113e63
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC17A8 WLS RBMS3 NOS1	4.65e-05	193	46	4	2189da4b727e25e62669d7b9257f06493be21a27
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Endothelial-nan\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GRIN2A ZBTB39 LRRC4C ADAMTS4	4.65e-05	193	46	4	2483bb7f398e4fa0ef09c8bd584ed25703853f03
ToppCell	RA\|World / Chamber and Cluster_Paper	BNC2 ADAMTS4 RBMS3 PTPRS	4.75e-05	194	46	4	08f0afbb68a63150fbe107a5337299081c3f69e4
ToppCell	LPS-antiTNF-Stromal_mesenchymal\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PTGES BNC2 PTPRS SYNE1	4.75e-05	194	46	4	6e13549f697f7478b34fe71f7dd9d63c5d3db22e
ToppCell	Control-Fibroblasts-Intermediate_pathological_FB\|Control / group, cell type (main and fine annotations)	BNC2 RFX8 ADAMTS4 RBMS3	4.75e-05	194	46	4	03a269f75a481ea54aea8e6444605db8d6df493d
ToppCell	Neuron-Postmitotic-Inhibitory_Neuron-MGE2\|World / Primary Cells by Cluster	GRIN2A WLS RBMS3 PCLO	4.75e-05	194	46	4	b42fd64b0fb95434a9e4e6586f31d26114a4074b
ToppCell	Neuron-Postmitotic-Inhibitory_Neuron-MGE2-10\|World / Primary Cells by Cluster	GRIN2A WLS RBMS3 PCLO	4.75e-05	194	46	4	81e7bc6516ab8d02ccd1c76a56a3533b788c27c8
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-neurons_B\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	BNC2 MAP6 PTPRS PCLO	4.75e-05	194	46	4	15224fb3e7ca5bd1fb8c41f8275842f737014095
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_NK-natural_killer_cell\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CCNJL PRMT2 BNC2 SYNE1	4.84e-05	195	46	4	49a4f58aac168fc1838bd5d2b202135cd794c28b
ToppCell	3'_v3-lymph-node_spleen-Lymphocytic_NK-NK_CD16\|lymph-node_spleen / Manually curated celltypes from each tissue	SELPLG PRMT2 BNC2 SYNE1	4.84e-05	195	46	4	e756733cf48768bf40058d6cf9039e52f7563133
ToppCell	Parenchymal-NucSeq-Stromal-Mesofibroblastic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DLGAP2 BNC2 FAM153B LRRC4C	4.84e-05	195	46	4	a52685f76eca269a7d2de8dfc317439483e233fa
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_NK-natural_killer_cell-female\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	CCNJL PRMT2 BNC2 SYNE1	4.84e-05	195	46	4	72f42f0be53a2a61f61647118b4883e752d998a5
ToppCell	Parenchymal-NucSeq-Stromal-Mesofibroblastic-Mesothelia\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	DLGAP2 BNC2 FAM153B LRRC4C	4.84e-05	195	46	4	224deeba2f60def6543a55bb4f5ee6c7fdab3f02
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal-nan\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGEF12 RELA RBMS3 OLFML2B	4.94e-05	196	46	4	66d76249bd2770cdddff2c1fe59a016e95da2124
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DLGAP2 GRIN2A SYNE1 PCLO	4.94e-05	196	46	4	676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m-Mesenchymal\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARHGEF12 RELA RBMS3 OLFML2B	4.94e-05	196	46	4	9bd4c146fc7555e32adfa393b3a07846eb826d25
ToppCell	facs-Aorta-Heart-3m-Mesenchymal-fibroblast_of_cardiac_tissue\|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WLS RBMS3 PTPRS OLFML2B	4.94e-05	196	46	4	2029f58ce6a7b8c35d3a7496c3341391990909ce
ToppCell	5'-Adult-Appendix\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAMTS4 RBMS3 PTPRS SYNE1	4.94e-05	196	46	4	a579211ef14f348d0c5a290553150222dfbf1515
ToppCell	distal-mesenchymal-Lipofibroblast-1\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	NR4A2 BNC2 ADAMTS4 PTPRS	5.04e-05	197	46	4	865010edcd7e3f79f505fcef7b33882095994aa8
ToppCell	distal-mesenchymal-Lipofibroblast\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	NR4A2 BNC2 ADAMTS4 PTPRS	5.04e-05	197	46	4	ceb83bdef16b58ee16193413bfb006f7715728b2
ToppCell	URO-Lymphocyte-T_NK-NK\|URO / Disease, Lineage and Cell Type	CCNJL PRMT2 BNC2 SYNE1	5.14e-05	198	46	4	2ccff882aafabf041df15b31d9abc50dcbc2696e
ToppCell	Fibroblasts-HLA-DRA_high_Fibroblasts\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	PTGES WLS RBMS3 OLFML2B	5.14e-05	198	46	4	e8c0fbf306fae13e97caa294d7c99a564bd97130
ToppCell	Somatosensory_Cortex_(S1)-Neuronal\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DLGAP2 GRIN2A SYNE1 PCLO	5.14e-05	198	46	4	c01091ef18e096d792ea2a7a715764a5b215355f
ToppCell	primary_auditory_cortex_(A1C)-Neuronal\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DLGAP2 GRIN2A SYNE1 PCLO	5.14e-05	198	46	4	6d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DLGAP2 GRIN2A SYNE1 PCLO	5.14e-05	198	46	4	8ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell	Tracheal-NucSeq-Stromal-Myofibroblastic-Muscle_smooth_airway_ASM\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	BNC2 FAM153B WLS SYNE1	5.14e-05	198	46	4	22e766df1276c5b14aa0d83f434f47140ebb98ea
ToppCell	severe-NK\|severe / disease stage, cell group and cell class	SELPLG PRMT2 BNC2 SYNE1	5.14e-05	198	46	4	cb505077dc5bdf3fdd513bb9032e32bb9644c004
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	DLGAP2 GRIN2A SYNE1 PCLO	5.14e-05	198	46	4	4ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal-6\|World / Primary Cells by Cluster	NR4A2 ARHGEF12 MAP6 PCLO	5.24e-05	199	46	4	1b1bccf4293f11048709d15a3c892c0edf3da3d2
ToppCell	Fibroblasts-CD34+_Fibroblasts\|World / Immune cells in Rheumatoid Arthritis Joint Synovial Tissues	BNC2 WLS RBMS3 PTPRS	5.24e-05	199	46	4	13ff7409e200a0b46cdb7924d15ef33639693622
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LRRC4C RNF128 NOS1 SYNE1	5.24e-05	199	46	4	19a97e27a4758e794ce7246d295e112b47931a48
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LRRC4C RNF128 NOS1 SYNE1	5.24e-05	199	46	4	333056c2abe9724efeab542c0365fcfe4eff8f18
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	LRRC4C RNF128 NOS1 SYNE1	5.24e-05	199	46	4	e60ecbb8fa7bcd3e2ce7d78f6efb2cfd1fd77698
ToppCell	Neuron-Postmitotic-Excitatory_Neuron_-Parietal_and_Temporal\|World / Primary Cells by Cluster	NR4A2 ARHGEF12 MAP6 PCLO	5.24e-05	199	46	4	4bee94c116c0da5eba951cb4cea7cc9dcdd6e30f
ToppCell	distal-1-mesenchymal-Lipofibroblast\|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	NR4A2 BNC2 ADAMTS4 PTPRS	5.24e-05	199	46	4	a8293db3c42a8d30897858b49aae7acfc18663ba
ToppCell	Neuronal-Inhibitory-iB-iB_4(SST)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLC17A8 WLS RBMS3 NOS1	5.34e-05	200	46	4	347a510755374c6a66acee326565dfc447993f18
ToppCell	Sepsis-URO-Lymphocyte-T/NK-NK\|URO / Disease, condition lineage and cell class	CCNJL PRMT2 BNC2 SYNE1	5.34e-05	200	46	4	741c7bad606c7e4d7db57d89aaf4dcf4232fa82a
ToppCell	Neuronal-Inhibitory-iB-iB_3(PVALB-SST)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	SLC17A8 WLS RBMS3 NOS1	5.34e-05	200	46	4	107854f4855fc99c9f7e737eb246f0d868e6c5fd
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	DLGAP2 GRIN2A SYNE1 PCLO	5.34e-05	200	46	4	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	Transplant_Alveoli_and_parenchyma-Mesenchymal-Mesothelium\|Transplant_Alveoli_and_parenchyma / Tissue, Lineage and Cell class of Lung Cells from 10X	BNC2 FAM153B LRRC4C RBMS3	5.34e-05	200	46	4	c082bc21ec7c5323439d108ea8aea510e1113c3f
ToppCell	control-NK\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	CCNJL PRMT2 BNC2 SYNE1	5.34e-05	200	46	4	3d924bb0ee84a9976de3c2e956188ade7486f8af
ToppCell	TCGA-Bone_and_Soft_Tissue-Primary_Tumor-Sarcoma-Undifferentiated_Pleomorphic_Sarcoma-7\|TCGA-Bone_and_Soft_Tissue / Sample_Type by Project: Shred V9	RFX8 ADAMTS4 OLFML2B	3.05e-04	127	46	3	c4809d8502f460370f824719d69b13b400a2b202
ToppCell	Control-Neu_1\|World / 5 Neutrophil clusters in COVID-19 patients	ADAMTS4 SQOR NOS1	3.89e-04	138	46	3	b7920c9a28d28220e7e4b30cd91ba13d0548eb76
ToppCell	COVID-19-kidney-Technical/muscle\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DLGAP2 LRRC4C NOS1	3.97e-04	139	46	3	13247bcb21c57c808657e0f543d6f134eeea7cc1
ToppCell	facs-Trachea-18m-Hematologic-myeloid-tracheal_macrophage-macrophage_of_trachea\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GRIN2A NOS1 CNTN2	3.97e-04	139	46	3	96e6fed23e7a69f678f85e8e2fe77a7491586b4b
ToppCell	PBMC-Control-Myeloid-Neutrophil-Neutrophil-Neu_1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ADAMTS4 SQOR NOS1	4.23e-04	142	46	3	191a13bba143ecdfc2bfd797c3ac191481388298
ToppCell	PBMC-Control-Myeloid-Neutrophil-Neutrophil-Neu_1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ADAMTS4 SQOR NOS1	4.32e-04	143	46	3	b405dba9a83a99cc7b53ce71772bc52a0bbb0d4e
ToppCell	COVID-19-kidney-Technical/muscle\|kidney / Disease (COVID-19 only), tissue and cell type	DLGAP2 LRRC4C NOS1	4.77e-04	148	46	3	0dbd87078f54ee1c2f8ec64e8bac9dfddb9c181e
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	DLGAP2 GRIN2A LRRC4C	4.77e-04	148	46	3	d6ac5972267254651dfbe16bb4e9a62228093cc7
ToppCell	facs-GAT-Fat-3m-Lymphocytic-NK_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NR4A2 SELPLG RFX8	5.06e-04	151	46	3	3d07b79ecbcfad13116f0f2b039bd181a7ffe853
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19\|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.	NOS2 RAI2 SON	5.46e-04	155	46	3	9d53caee196b5c2bbc90c4f54f693b64d4086065
ToppCell	343B-Myeloid-Macrophage-SPP1+_Macrophage_3\|Macrophage / Donor, Lineage, Cell class and subclass (all cells)	NR4A2 BNC2 IQCN	5.46e-04	155	46	3	c4dc0fa1d0e657753a56939eb4829fb60382c17f
ToppCell	facs-Spleen-nan-24m-Myeloid\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SQOR OLFML2B SYNE1	5.56e-04	156	46	3	034d4359359a44c205c6931f38a375271ac2752b
ToppCell	facs-Spleen-nan-24m-Myeloid-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SQOR OLFML2B SYNE1	5.56e-04	156	46	3	2a4dac4100c0339aad4905b8eaca6e8fe806718b
ToppCell	facs-Spleen-nan-24m-Myeloid-granulocyte\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SQOR OLFML2B SYNE1	5.56e-04	156	46	3	21267718d3a3dc19988663b6846aed8bb3eae836
ToppCell	BL-critical-LOC-Epithelial-FOXN4+\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	CTAG2 DLGAP2 NOS2	5.99e-04	160	46	3	3f737451d5713deed20061aa72a9ef77a9a2bc06
ToppCell	facs-Lung-Endomucin-3m-Lymphocytic-CD4+_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELPLG ABHD18 CNTN2	5.99e-04	160	46	3	5c68d6a76c59e3a7e668ae5471396478a55756ac
ToppCell	facs-Lung-Endomucin-3m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELPLG ABHD18 CNTN2	5.99e-04	160	46	3	0fee84844733d36805e1df90ca09478169746708
ToppCell	droplet-Liver-HEPATOCYTES-1m-Epithelial-Hepatocyte_(Pericentral)\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC17A8 TKFC RNF128	5.99e-04	160	46	3	c42bcc6c7d113f0db43febb088b75ca4ac7cb7a3
ToppCell	ICU-SEP-Myeloid-cDC1\|ICU-SEP / Disease, Lineage and Cell Type	CTAG2 NR4A2 BEGAIN	6.10e-04	161	46	3	9fb73909fc2ec99f96ca2eed1a053bce89de7d16
ToppCell	Healthy_donor-CD8+_T_naive\|World / disease group, cell group and cell class (v2)	PRMT2 NOS2 RAI2	6.10e-04	161	46	3	8a61395af33132783a0a37956c6f821aba5d3b1e
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CDRT4 IQCN NOS1	6.21e-04	162	46	3	373513f9d0e5007b2e10a8b78d4909dcce9e3b62
ToppCell	368C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	LRRC4C WLS SYNE1	6.32e-04	163	46	3	4b8abbad4df040c895e3afb240759ebbc66b4d0e
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CCNJL GRIN2A LRRC4C	6.43e-04	164	46	3	382e42701779d12a7948690b3be72d06dd75c8b4
ToppCell	facs-Kidney-nan-24m-Mesenchymal-mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTGES RBMS3 BEGAIN	6.55e-04	165	46	3	c746bb22ef52d7f7fa6ee9c37ae6bbe0ccce718e
ToppCell	facs-Kidney-nan-24m-Mesenchymal-mesangial_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTGES RBMS3 BEGAIN	6.55e-04	165	46	3	4cdd80580d5638fd649280ba3893251c2f898f3f
ToppCell	droplet-Spleen-nan-24m-Myeloid-granulocyte\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SQOR OLFML2B SYNE1	6.55e-04	165	46	3	3cdb921f5b9facf04f81995d5641ac14ef3dbb6f
ToppCell	Dendritic_Cells-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	NR4A2 BRD8 OLFML2B	6.66e-04	166	46	3	fbeb74b98b58085de323f744b18d4a8f7b22d5d4
ToppCell	TCGA-Colorectal-Solid_Tissue_Normal-Colon_normal_tissue-Colon_normal_tissue-9\|TCGA-Colorectal / Sample_Type by Project: Shred V9	MAP6 NOS1 CNTN2	6.66e-04	166	46	3	68e6fc7c0040bbe48a93f96ecf28afffdc626845
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-Tnaive/CM_CD4\|Liver / Manually curated celltypes from each tissue	DLGAP2 FAM153B RAI2	6.78e-04	167	46	3	ab6273ae5d76a3f9a05c58320e3dee80f9b99e47
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-BM_CD4_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RNF128 MAP6 NOS1	6.78e-04	167	46	3	d30b96c39da3dd02500443877a4eb3500e26802c
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	BNC2 LRRC4C ZAN	6.78e-04	167	46	3	3edb0570e583bb527165bcd8a4c25a042054043b
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RNF128 MAP6 NOS1	6.78e-04	167	46	3	713899690e4acd9d259645e363c26983d6ef3022
ToppCell	droplet-Spleen-nan-21m-Myeloid-granulocyte\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SQOR OLFML2B SYNE1	6.78e-04	167	46	3	cfcd72292c733cdb18c92fdb61b68f6806d22c8c
ToppCell	Immune_cells-Neutrophils\|Immune_cells / Lineage and Cell class	SQOR OLFML2B SYNE1	6.90e-04	168	46	3	3539f802fe0143da1462df0618f78f9f15143f71
ToppCell	droplet-Spleen-SPLEEN-30m-Myeloid-granulocyte\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SQOR OLFML2B SYNE1	6.90e-04	168	46	3	c0ff30e2c47005514131a0866cf10a1c228128fc
ToppCell	AT1-AT2_cells-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	RNF128 RBMS3 PCLO	7.02e-04	169	46	3	815474855a70498a74e52f6583113c63b7267a0c
ToppCell	droplet-Spleen-SPLEEN-30m-Myeloid-nan\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SQOR OLFML2B SYNE1	7.02e-04	169	46	3	1000eaf5158596b4898bedcc802b31db76b05a48
Drug	arvelexin	PTGES RELA NOS2	1.54e-07	6	46	3	ctd:C500823
Drug	di-n-butyltin	RELA NOS1 NOS2	1.26e-06	11	46	3	ctd:C056189
Drug	Tropicamide	RELA NOS1 NOS2	1.68e-06	12	46	3	ctd:D014331
Drug	Kainic Acid	NR4A2 RELA GRIN2A REST NOS1 NOS2	2.50e-06	194	46	6	ctd:D007608
Drug	methoctramine	RELA NOS1 NOS2	2.77e-06	14	46	3	ctd:C054938
Drug	N-Omega-Propyl-L-Arginine	NOS1 NOS2	3.99e-06	2	46	2	DB02644
Drug	N-(4-(2-((3-Chlorophenylmethyl)Amino)Ethyl)Phenyl)-2-Thiophecarboxamidine	NOS1 NOS2	3.99e-06	2	46	2	DB03449
Drug	7,8-diacetoxy-4-methylcoumarin	RELA NOS1 NOS2	5.15e-06	17	46	3	ctd:C114369
Drug	Mevinphos	RELA NOS1 NOS2	5.15e-06	17	46	3	ctd:D008799
Drug	dimemorfan	RELA NOS1 NOS2	5.15e-06	17	46	3	ctd:C012621
Drug	Mn(III) 5,10,15,20-tetrakis(N-methylpyridinium-2-yl)porphyrin	RELA NOS1 NOS2	1.00e-05	21	46	3	ctd:C502230
Drug	N-(3-(Aminomethyl)Benzyl)Acetamidine	NOS1 NOS2	1.20e-05	3	46	2	DB02044
Drug	3-Bromo-7-Nitroindazole	NOS1 NOS2	1.20e-05	3	46	2	DB01997
Drug	SC-514	PTGES RELA NOS2	1.72e-05	25	46	3	CID002807869
Drug	triflusal	RELA NOS1 NOS2	1.72e-05	25	46	3	CID000009458
Drug	tert-butylcatechol	RELA NOS2	2.39e-05	4	46	2	ctd:C038096
Drug	(6r,1'r,2's)-5,6,7,8 Tetrahydrobiopterin	NOS1 NOS2	2.39e-05	4	46	2	DB02692
Drug	3-methylcatechol	RELA NOS2	2.39e-05	4	46	2	ctd:C031136
Drug	N-Omega-Hydroxy-L-Arginine	NOS1 NOS2	2.39e-05	4	46	2	DB03144
Drug	Yohimbine	RELA ADAMTS4 NOS2	3.02e-05	30	46	3	ctd:D015016
Drug	NSC-6354	RELA ACOT8 NOS1 NOS2	3.58e-05	92	46	4	CID000221534
Drug	meclofenamate	PTGES TKFC NOS1 NOS2	3.89e-05	94	46	4	CID000004036
Drug	catalposide	RELA NOS2	3.98e-05	5	46	2	CID000093039
Drug	5-hydroxy-3,6,7,8,3',4'-hexamethoxyflavone	RELA NOS2	3.98e-05	5	46	2	ctd:C521815
Drug	1-naphthylethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline	RELA NOS2	3.98e-05	5	46	2	ctd:C471009
Drug	1-(beta-naphthylmethyl)-6,7-dihydroxy-1,2,3,4-tetra-hydroisoquinoline	RELA NOS2	3.98e-05	5	46	2	ctd:C495109
Drug	epimuqubilin A	RELA NOS2	3.98e-05	5	46	2	ctd:C553039
Drug	cacospongionolide B	RELA NOS2	3.98e-05	5	46	2	ctd:C098384
Drug	glyceryl-isoeugenol	RELA NOS2	3.98e-05	5	46	2	ctd:C560287
Drug	4-(nitroxy)butanoic acid 4-acetylaminophenyl ester	NOS1 NOS2	3.98e-05	5	46	2	ctd:C478738
Drug	Antazoline hydrochloride [2508-72-7]; Up 200; 13.2uM; HL60; HG-U133A	BNC2 PRR14 SON BEGAIN PCIF1	4.40e-05	194	46	5	1556_UP
Drug	pioglitazone HCl; Up 200; 10uM; MCF7; HT_HG-U133A	NR4A2 REST NOS1 SYNE1 BEGAIN	4.74e-05	197	46	5	5972_UP
Drug	LY 294002; Up 200; 10uM; HL60; HT_HG-U133A	NR4A2 PRMT2 NOS1 PCLO RAI2	4.74e-05	197	46	5	6198_UP
Drug	Cyclopenthiazide [742-20-1]; Down 200; 10.6uM; HL60; HT_HG-U133A	NR4A2 PRMT2 BNC2 REST PCLO	5.09e-05	200	46	5	2905_DN
Drug	lipoteichoic acid	RELA GRIN2A NOS2	5.26e-05	36	46	3	ctd:C009900
Drug	3-bromo-7-nitroindazole	GRIN2A NOS1 NOS2	5.26e-05	36	46	3	CID000001649
Drug	panobinostat	BNC2 RELA GRIN2A REST WLS MAP6 RBMS3 SQOR SYNE1 CNTN2 BEGAIN	5.30e-05	1333	46	11	ctd:C496932
Drug	gigantol	RELA NOS2	5.96e-05	6	46	2	ctd:C478099
Drug	ruboxistaurin	RELA NOS2	5.96e-05	6	46	2	ctd:C099154
Drug	orazipone	RELA NOS2	5.96e-05	6	46	2	ctd:C502617
Drug	NapNa	NOS1 NOS2	5.96e-05	6	46	2	CID000128726
Drug	aciculatin	RELA NOS2	5.96e-05	6	46	2	ctd:C074400
Drug	N-nitroso-L-arginine	NOS1 NOS2	5.96e-05	6	46	2	CID000127762
Drug	1-hexacosanol	NOS1 NOS2	5.96e-05	6	46	2	ctd:C051942
Drug	dimethoxycurcumin	RELA NOS2	5.96e-05	6	46	2	ctd:C521105
Drug	toxB protein, Clostridium difficile	RELA NOS2	5.96e-05	6	46	2	ctd:C031815
Drug	Carrageenan	PTGES RELA NOS2	6.20e-05	38	46	3	ctd:D002351
Drug	Selenomethionine	RELA ADAMTS4 NOS1 NOS2	6.70e-05	108	46	4	ctd:D012645
Drug	sodium bisulfide	RELA NOS1 NOS2	7.24e-05	40	46	3	ctd:C025451
Drug	nitroflurbiprofen	RELA NOS2	8.33e-05	7	46	2	ctd:C095631
Drug	Lentinan	RELA NOS2	8.33e-05	7	46	2	ctd:D007912
Drug	asarone	RELA NOS2	8.33e-05	7	46	2	ctd:C012195
Drug	bis(3-hydroxyphenyl) diselenide	RELA NOS2	8.33e-05	7	46	2	ctd:C541028
Drug	4-methylcatechol	RELA NOS2	8.33e-05	7	46	2	ctd:C018599
Drug	petrosaspongiolide m	RELA NOS2	8.33e-05	7	46	2	ctd:C118309
Drug	AC1NLRUC	NOS1 NOS2	8.33e-05	7	46	2	CID004988604
Drug	AC1L1KON	RELA ADAMTS4 NOS1 NOS2	8.56e-05	115	46	4	CID000005589
Drug	Dinoprostone	PTGES NR4A2 RELA GRIN2A NOS2	8.88e-05	225	46	5	ctd:D015232
Drug	naftidrofuryl	PTGES NOS1 NOS2	9.00e-05	43	46	3	CID000004417
Drug	p-hydroxymandelonitrile	SELPLG ARHGEF12 NOS1 NOS2	9.15e-05	117	46	4	CID000166768
Drug	nitrosonium	GRIN2A NOS1 NOS2	9.65e-05	44	46	3	CID000084878
Drug	AC1LA6XC	SLC17A8 NOS1 NOS2	1.03e-04	45	46	3	CID000482573
Drug	shogaol	PTGES RELA NOS2	1.10e-04	46	46	3	ctd:C040115
Drug	pelargonidin	RELA NOS2	1.11e-04	8	46	2	ctd:C066957
Drug	beta-hydroxyisovalerylshikonin	RELA NOS2	1.11e-04	8	46	2	ctd:C118460
Drug	(5-formylfuran-2-yl)methyl 4-hydroxy-2-methylenebutanoate	RELA NOS2	1.11e-04	8	46	2	ctd:C575152
Drug	NSC 329246	NOS2 SYNE1	1.11e-04	8	46	2	CID000100067
Drug	NSC364150	RELA NOS2 SYNE1	1.25e-04	48	46	3	CID000100771
Drug	Ammonia	RELA NOS1 NOS2	1.25e-04	48	46	3	ctd:D000641
Drug	Lithium	NR4A2 RELA GRIN2A NOS1 NOS2	1.35e-04	246	46	5	ctd:D008094
Drug	pseudococaine	NR4A2 SLC17A8 RELA PRR14 GRIN2A NOS1 NOS2	1.36e-04	570	46	7	CID000002826
Drug	icariin	RELA NOS1 NOS2	1.42e-04	50	46	3	ctd:C056599
Drug	labdanolic acid methyl ester	RELA NOS2	1.42e-04	9	46	2	ctd:C570295
Drug	monotropein	RELA NOS2	1.42e-04	9	46	2	ctd:C507582
Drug	Aminoimidazole Carboxamide	RELA NOS2	1.42e-04	9	46	2	ctd:D000620
Drug	Vi-o	NOS1 NOS2	1.42e-04	9	46	2	CID005289554
Drug	17-hydroxyjolkinolide B	RELA NOS2	1.42e-04	9	46	2	ctd:C057916
Drug	astragalin	RELA NOS2	1.42e-04	9	46	2	ctd:C001579
Drug	bifendate	RELA NOS2	1.42e-04	9	46	2	ctd:C465548
Drug	7-(2-(cyclopropylmethoxy)-6-hydroxyphenyl)-5-(3-piperidinyl)-1,4-dihydro-2H-pyrido(2,3-d)(1,3)oxazin-2-one	RELA NOS2	1.42e-04	9	46	2	ctd:C502972
Drug	Reactive Nitrogen Species	NOS1 NOS2	1.42e-04	9	46	2	ctd:D026361
Drug	flavokawain A	RELA NOS2	1.42e-04	9	46	2	ctd:C500809
Drug	S-nitroso-N-acetyl-D,L-penicillamine	RELA GRIN2A NOS1 NOS2	1.55e-04	134	46	4	CID000005231
Drug	ASA404	RELA NOS1 NOS2	1.68e-04	53	46	3	CID000123964
Drug	diethylamine	GRIN2A NOS1 NOS2	1.68e-04	53	46	3	CID000008021
Drug	3-methylquercetin	PTGES RELA NOS2	1.68e-04	53	46	3	ctd:C047368
Drug	trikatu	RELA NOS2	1.78e-04	10	46	2	ctd:C540456
Drug	eupatilin	RELA NOS2	1.78e-04	10	46	2	ctd:C045325
Drug	KMUP 1	NOS1 NOS2	1.78e-04	10	46	2	ctd:C439304
Drug	soyasaponin I	RELA NOS2	1.78e-04	10	46	2	ctd:C056684
Drug	AC1N6UEL	RELA NOS2	1.78e-04	10	46	2	CID004221373
Drug	O-(chloroacetylcarbamoyl)fumagillol	RELA NOS2	1.78e-04	10	46	2	ctd:C066515
Drug	sinapinic acid	RELA NOS2	1.78e-04	10	46	2	ctd:C073734
Drug	loganin	RELA NOS2	1.78e-04	10	46	2	ctd:C059516
Drug	ramiprilat	RELA NOS1 NOS2	1.88e-04	55	46	3	CID005464096
Drug	DE gel	ACOT8 GRIN2A NOS1 NOS2	1.98e-04	143	46	4	CID000008146
Drug	nitrone	TKFC NOS2 SYNE1	2.09e-04	57	46	3	CID000006350
Drug	benzoyl isothiocyanate	NOS1 NOS2	2.17e-04	11	46	2	CID000068284
Drug	guanidinoglutaric acid	NOS1 NOS2	2.17e-04	11	46	2	CID000002105
Drug	glutamyl-(2-(((3,4-dihydro-2,5,7,8-tetramethyl-2-(4,8,12-trimethyltridecyl)-2H-1-benzopyran-6-yl)oxy)carbonyl)-3-((2-(1H-indol-3-yl)ethyl)amino)-3-oxopropyl)-cysteinyl-glycine sodium salt	RELA NOS2	2.17e-04	11	46	2	ctd:C475739
Disease	wellbeing measurement	NR4A2 DLGAP2 BNC2 GRIN2A ATXN2 RBMS3 NOS1 PCLO	6.17e-06	692	43	8	EFO_0007869
Disease	Parkinsonism (biomarker_via_orthology)	NR4A2 SLC17A8 NOS1	1.67e-05	34	43	3	DOID:0080855 (biomarker_via_orthology)
Disease	depressive symptom measurement	NR4A2 DLGAP2 BNC2 RBMS3 NOS1 PCLO	3.39e-05	426	43	6	EFO_0007006
Disease	Schizophrenia	NR4A2 DLGAP2 RELA GRIN2A REST ATXN2 MAP6 NOS1	3.57e-05	883	43	8	C0036341
Disease	Morphine Abuse	GRIN2A NOS1	4.34e-05	7	43	2	C0600272
Disease	Morphine Dependence	GRIN2A NOS1	4.34e-05	7	43	2	C0026552
Disease	Hepatic Insufficiency	RELA NOS2	7.42e-05	9	43	2	C1306571
Disease	Parkinson disease, late-onset	NR4A2 ATXN2	9.27e-05	10	43	2	cv:C3160718
Disease	PARKINSON DISEASE, LATE-ONSET	NR4A2 ATXN2	9.27e-05	10	43	2	168600
Disease	schizophrenia (implicated_via_orthology)	NR4A2 MAP6 NOS1	1.35e-04	68	43	3	DOID:5419 (implicated_via_orthology)
Disease	retinopathy of prematurity (biomarker_via_orthology)	NOS1 NOS2	1.36e-04	12	43	2	DOID:13025 (biomarker_via_orthology)
Disease	PARKINSON DISEASE, LATE-ONSET	NR4A2 ATXN2	1.36e-04	12	43	2	C3160718
Disease	Arthritis, Psoriatic	NR4A2 NOS2	1.87e-04	14	43	2	C0003872
Disease	5-methyluridine (ribothymidine) measurement	PTPRS PCLO	1.87e-04	14	43	2	EFO_0020013
Disease	hepatic encephalopathy (biomarker_via_orthology)	NOS1 NOS2	2.15e-04	15	43	2	DOID:13413 (biomarker_via_orthology)
Disease	Fetal Alcohol Syndrome	REST NOS1	2.78e-04	17	43	2	C0015923
Disease	neuroticism measurement	NR4A2 DLGAP2 BNC2 RBMS3 SQOR NOS1 PCLO	3.15e-04	909	43	7	EFO_0007660
Disease	renovascular hypertension (biomarker_via_orthology)	RELA NOS1	3.49e-04	19	43	2	DOID:1591 (biomarker_via_orthology)
Disease	epilepsy (biomarker_via_orthology)	NR4A2 RELA	4.28e-04	21	43	2	DOID:1826 (biomarker_via_orthology)
Disease	Visual seizure	REST NOS1 NOS2	4.35e-04	101	43	3	C0270824
Disease	Epileptic drop attack	REST NOS1 NOS2	4.35e-04	101	43	3	C0270846
Disease	Generalized seizures	REST NOS1 NOS2	4.35e-04	101	43	3	C0234533
Disease	Clonic Seizures	REST NOS1 NOS2	4.35e-04	101	43	3	C0234535
Disease	Vertiginous seizure	REST NOS1 NOS2	4.35e-04	101	43	3	C0422855
Disease	Gustatory seizure	REST NOS1 NOS2	4.35e-04	101	43	3	C0422854
Disease	Seizures, Somatosensory	REST NOS1 NOS2	4.35e-04	101	43	3	C0422850
Disease	Olfactory seizure	REST NOS1 NOS2	4.35e-04	101	43	3	C0422853
Disease	Seizures, Auditory	REST NOS1 NOS2	4.35e-04	101	43	3	C0422852
Disease	Generalized Absence Seizures	REST NOS1 NOS2	4.35e-04	101	43	3	C4505436
Disease	Convulsive Seizures	REST NOS1 NOS2	4.35e-04	101	43	3	C0751494
Disease	Seizures, Sensory	REST NOS1 NOS2	4.35e-04	101	43	3	C0751496
Disease	Jacksonian Seizure	REST NOS1 NOS2	4.35e-04	101	43	3	C0022333
Disease	Non-epileptic convulsion	REST NOS1 NOS2	4.35e-04	101	43	3	C0751056
Disease	Atonic Absence Seizures	REST NOS1 NOS2	4.35e-04	101	43	3	C0751123
Disease	Complex partial seizures	REST NOS1 NOS2	4.35e-04	101	43	3	C0149958
Disease	Single Seizure	REST NOS1 NOS2	4.35e-04	101	43	3	C0751110
Disease	Epileptic Seizures	REST NOS1 NOS2	4.35e-04	101	43	3	C4317109
Disease	Nonepileptic Seizures	REST NOS1 NOS2	4.35e-04	101	43	3	C3495874
Disease	Tonic Seizures	REST NOS1 NOS2	4.48e-04	102	43	3	C0270844
Disease	Absence Seizures	REST NOS1 NOS2	4.48e-04	102	43	3	C4316903
Disease	Convulsions	REST NOS1 NOS2	4.48e-04	102	43	3	C4048158
Disease	impotence (biomarker_via_orthology)	NOS1 NOS2	4.70e-04	22	43	2	DOID:1875 (biomarker_via_orthology)
Disease	Parkinson disease	NR4A2 ATXN2	4.70e-04	22	43	2	cv:C0030567
Disease	Seizures, Focal	REST NOS1 NOS2	4.74e-04	104	43	3	C0751495
Disease	Myoclonic Seizures	REST NOS1 NOS2	4.74e-04	104	43	3	C4317123
Disease	Tonic - clonic seizures	REST NOS1 NOS2	4.74e-04	104	43	3	C0494475
Disease	Ureteral obstruction	RELA NOS2	5.61e-04	24	43	2	C0041956
Disease	Autistic Disorder	NR4A2 DLGAP2 GRIN2A NOS2	5.63e-04	261	43	4	C0004352
Disease	Colitis	RELA NOS2	6.09e-04	25	43	2	C0009319
Disease	acute necrotizing pancreatitis (biomarker_via_orthology)	RELA NOS2	6.59e-04	26	43	2	DOID:0080998 (biomarker_via_orthology)
Disease	response to methotrexate, drug-induced liver injury	ARHGEF12 RBMS3	6.59e-04	26	43	2	EFO_0004228, GO_0031427
Disease	Fever	PTGES NOS1	7.11e-04	27	43	2	C0015967
Disease	lissencephaly (implicated_via_orthology)	NOS1 NOS2	7.11e-04	27	43	2	DOID:0050453 (implicated_via_orthology)
Disease	obstructive sleep apnea (is_marker_for)	RELA NOS2	8.21e-04	29	43	2	DOID:0050848 (is_marker_for)
Disease	Autosomal dominant nonsyndromic hearing loss	SLC17A8 REST	8.21e-04	29	43	2	cv:C5779548
Disease	bipolar disorder (is_implicated_in)	GRIN2A SYNE1	8.21e-04	29	43	2	DOID:3312 (is_implicated_in)
Disease	Depressive disorder	GRIN2A NOS1 NOS2 PCLO	8.23e-04	289	43	4	C0011581
Disease	Cholestasis, Extrahepatic	RELA NOS2	1.00e-03	32	43	2	C0005398

Protein segments in the cluster

Peptide	Gene	Start	Entry
MQHQFSMPTVPPPEE	ACOT8	136	O14734
MMDDPVPVHTGDVVT	PRMT2	376	P55345
HITMPFSSPMEAELV	CTAG2	91	O75638
PMEAVGDPHTVTVSM	BRD8	341	Q9H0E9
EPSSMEASPEMHPAA	BEGAIN	546	Q9BUH8
PVVPAVMMATHEPSA	BNC2	611	Q6ZN30
PMAHYVPDIMPIESV	ABHD18	76	Q0P651
CPVPVPASLSMHMAI	CCNJL	391	Q8IV13
PRSSVHSECVMMPVV	DLGAP2	136	Q9P1A6
TAMPAEHVAVQVPAP	DDX20	16	Q9UHI6
VEPSVIGHMSPIMTS	ARHGEF12	161	Q9NZN5
SPVVMPIHMQVEGSS	RAI2	86	Q9Y5P3
QPTGAVITPTMDHPM	RBMS3	311	Q6XE24
APHTCPMPTMTKIQV	IQCN	391	Q9H0B3
PMPTMTKIQVHPTAS	IQCN	396	Q9H0B3
SVLAMAPTMIPEPTH	CDRT4	106	Q8N9R6
PPMSGSITPVFHQEM	NOS2	466	P35228
VLAHMELPPPMETAQ	REST	681	Q13127
PMVPEHPKDESAMAT	MAP6	641	Q96JE9
MAAPPQPVTHLIFDM	PUDP	1	Q08623
VPSHPTAHAPMMLMT	ATXN2	1256	Q99700
AVTSLPAMHHSQPMP	PCLO	3126	Q9Y6V0
TGDTPMESHLPMPAI	LRRC4C	576	Q9HCJ2
PPMSGSITPVFHQEM	NOS1	686	P29475
SMLSHPPIPIADMAE	PTPRS	1366	Q13332
TSRHVMAPVMAHVDP	ADAMTS4	386	O75173
VSAPPMPSVEMHMEN	PCIF1	411	Q9H4Z3
TSMMVENMAVRPAPH	CNTN2	1006	Q02246
EATGVHMMQVDPATP	FAM153B	271	P0C7A2
LPPQSEEMMPHSGSV	NR4A2	106	P43354
PAAMEAQTTPPAAME	SELPLG	206	Q14242
VISYEMLHVTPPMSP	SQOR	286	Q9Y6N5
LPTPSAHPSVVMMTA	SYNE1	5836	Q8NF91
LEDVMAVHMVPVVPS	PRR14	56	Q9BWN1
IPMSHPGAVDIVAIM	RNF128	156	Q8TEB7
MPAHSLVMSSPALPA	PTGES	1	O14684
EALMEAMHTVPVPPT	OLFML2B	441	Q68BL8
ASPSMEPLGVMPTHM	RFX8	486	Q6ZV50
PVVMESAAAIAPQMP	TEX13C	251	A0A0J9YWL9
DHDTPAPFTSIPSMM	ZBTB39	211	O15060
VFSVHIPLPHMEMSP	WLS	91	Q5T9L3
ASHVPVQPGSSVVMM	TKFC	251	Q3LXA3
GIPVAPHTTEPMLME	RELA	481	Q04206
MSAEPTVLASEPPVM	SON	1291	P18583
SAVPHMVMTIVVPIG	SLC17A8	356	Q8NDX2
VMSPHAPSTPMTSVI	ZAN	1016	Q9Y493
RPEVPMHTLHPFMVN	GRIN2A	326	Q12879