Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	RNA polymerase II transcription regulatory region sequence-specific DNA binding	ZSCAN29 ZNF449 ZNF69 CPHXL ZNF772 ZNF555 ZNF763 ZNF439 ZNF277 ZNF879 ZNF596 CPHXL2 ZNF440 ZNF77	1.76e-09	1459	28	14	GO:0000977
GeneOntologyMolecularFunction	DNA-binding transcription factor activity, RNA polymerase II-specific	ZSCAN29 ZNF449 ZNF69 CPHXL ZNF772 ZNF555 ZNF439 ZNF879 ZNF596 CPHXL2 ZNF440 ZNF77	1.56e-07	1412	28	12	GO:0000981
GeneOntologyMolecularFunction	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ZSCAN29 ZNF449 CPHXL ZNF772 ZNF763 ZNF277 ZNF879 CPHXL2	2.24e-04	1244	28	8	GO:0000978
GeneOntologyMolecularFunction	cis-regulatory region sequence-specific DNA binding	ZSCAN29 ZNF449 CPHXL ZNF772 ZNF763 ZNF277 ZNF879 CPHXL2	2.60e-04	1271	28	8	GO:0000987
GeneOntologyMolecularFunction	histone H3K4 methyltransferase activity	WDR5 SETMAR	3.55e-04	20	28	2	GO:0042800
GeneOntologyMolecularFunction	histone H3 methyltransferase activity	WDR5 SETMAR	1.73e-03	44	28	2	GO:0140938
GeneOntologyMolecularFunction	histone modifying activity	WDR5 SETMAR USP22	3.95e-03	229	28	3	GO:0140993
GeneOntologyMolecularFunction	protein-lysine N-methyltransferase activity	WDR5 SETMAR	4.08e-03	68	28	2	GO:0016279
GeneOntologyMolecularFunction	lysine N-methyltransferase activity	WDR5 SETMAR	4.20e-03	69	28	2	GO:0016278
GeneOntologyMolecularFunction	histone methyltransferase activity	WDR5 SETMAR	4.44e-03	71	28	2	GO:0042054
GeneOntologyCellularComponent	Set1C/COMPASS complex	WDR5 WDR5B	2.05e-04	16	28	2	GO:0048188
GeneOntologyCellularComponent	extrinsic component of synaptic membrane	DGKB RIMS1	1.00e-03	35	28	2	GO:0099243
GeneOntologyCellularComponent	SAGA-type complex	WDR5 USP22	1.24e-03	39	28	2	GO:0070461
Domain	zf-C2H2	ZSCAN29 ZNF449 ZNF69 ZNF772 ZNF555 ZNF763 ZNF439 ZNF277 ZNF879 ZNF596 ZNF440 ZNF77	3.71e-11	693	26	12	PF00096
Domain	ZINC_FINGER_C2H2_2	ZSCAN29 ZNF449 ZNF69 ZNF772 ZNF555 ZNF763 ZNF439 ZNF277 ZNF879 ZNF596 ZNF440 ZNF77	1.35e-10	775	26	12	PS50157
Domain	ZINC_FINGER_C2H2_1	ZSCAN29 ZNF449 ZNF69 ZNF772 ZNF555 ZNF763 ZNF439 ZNF277 ZNF879 ZNF596 ZNF440 ZNF77	1.39e-10	777	26	12	PS00028
Domain	Znf_C2H2-like	ZSCAN29 ZNF449 ZNF69 ZNF772 ZNF555 ZNF763 ZNF439 ZNF277 ZNF879 ZNF596 ZNF440 ZNF77	1.84e-10	796	26	12	IPR015880
Domain	Znf_C2H2	ZSCAN29 ZNF449 ZNF69 ZNF772 ZNF555 ZNF763 ZNF439 ZNF277 ZNF879 ZNF596 ZNF440 ZNF77	2.10e-10	805	26	12	IPR007087
Domain	ZnF_C2H2	ZSCAN29 ZNF449 ZNF69 ZNF772 ZNF555 ZNF763 ZNF439 ZNF277 ZNF879 ZNF596 ZNF440 ZNF77	2.19e-10	808	26	12	SM00355
Domain	-	ZSCAN29 ZNF449 ZNF69 ZNF772 ZNF555 ZNF763 ZNF439 ZNF879 ZNF596 ZNF440 ZNF77	6.35e-10	679	26	11	3.30.160.60
Domain	KRAB	ZNF69 ZNF772 ZNF555 ZNF763 ZNF439 ZNF879 ZNF596 ZNF440 ZNF77	7.41e-10	358	26	9	PS50805
Domain	KRAB	ZNF69 ZNF772 ZNF555 ZNF763 ZNF439 ZNF879 ZNF596 ZNF440 ZNF77	7.41e-10	358	26	9	PF01352
Domain	Znf_C2H2/integrase_DNA-bd	ZSCAN29 ZNF449 ZNF69 ZNF772 ZNF555 ZNF763 ZNF439 ZNF879 ZNF596 ZNF440 ZNF77	8.00e-10	694	26	11	IPR013087
Domain	KRAB	ZNF69 ZNF772 ZNF555 ZNF763 ZNF439 ZNF879 ZNF596 ZNF440 ZNF77	9.67e-10	369	26	9	SM00349
Domain	KRAB	ZNF69 ZNF772 ZNF555 ZNF763 ZNF439 ZNF879 ZNF596 ZNF440 ZNF77	9.90e-10	370	26	9	IPR001909
Domain	zf-C2H2_6	ZNF449 ZNF69 ZNF555 ZNF763 ZNF439 ZNF879 ZNF440 ZNF77	7.01e-09	314	26	8	PF13912
Domain	Furin-like_2	RSPO3 RSPO1	1.12e-05	4	26	2	PF15913
Domain	Gprotein_B	WDR5 WDR5B	8.33e-05	10	26	2	IPR001632
Domain	TSP_1	ADAMTS18 RSPO3 RSPO1	9.00e-05	63	26	3	PF00090
Domain	TSP1_rpt	ADAMTS18 RSPO3 RSPO1	9.88e-05	65	26	3	IPR000884
Domain	TSP1	ADAMTS18 RSPO3 RSPO1	9.88e-05	65	26	3	PS50092
Domain	TSP1	ADAMTS18 RSPO3 RSPO1	9.88e-05	65	26	3	SM00209
Domain	Furin_repeat	RSPO3 RSPO1	2.81e-04	18	26	2	IPR006212
Domain	FU	RSPO3 RSPO1	2.81e-04	18	26	2	SM00261
Domain	Growth_fac_rcpt_	RSPO3 FAT4 RSPO1	1.29e-03	156	26	3	IPR009030
Domain	SCAN	ZSCAN29 ZNF449	2.74e-03	56	26	2	SM00431
Domain	SCAN_BOX	ZSCAN29 ZNF449	2.94e-03	58	26	2	PS50804
Domain	SCAN	ZSCAN29 ZNF449	2.94e-03	58	26	2	PF02023
Domain	SCAN_dom	ZSCAN29 ZNF449	2.94e-03	58	26	2	IPR003309
Domain	Retrov_capsid_C	ZSCAN29 ZNF449	3.04e-03	59	26	2	IPR008916
Domain	G-protein_beta_WD-40_rep	WDR5 WDR5B	6.20e-03	85	26	2	IPR020472
Pathway	WP_MARKERS_OF_KIDNEY_CELL_LINEAGE	RSPO3 FAT4 RSPO1	4.54e-05	59	17	3	M46460
Pathway	REACTOME_RNA_POLYMERASE_II_TRANSCRIPTION	RSPO3 WDR5 ZNF772 ZNF555 ZNF439 ZNF596 ZNF440 ZNF77	9.28e-05	1387	17	8	M734
Pathway	WP_NEPHROGENESIS	RSPO3 RSPO1	2.07e-04	18	17	2	M40045
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_LGR_RSPO	RSPO3 RSPO1	2.31e-04	19	17	2	M47833
Pathway	REACTOME_REGULATION_OF_FZD_BY_UBIQUITINATION	RSPO3 RSPO1	2.57e-04	20	17	2	MM15155
Pathway	REACTOME_REGULATION_OF_FZD_BY_UBIQUITINATION	RSPO3 RSPO1	2.84e-04	21	17	2	M27401
Pubmed	A WNT/beta-catenin signaling activator, R-spondin, plays positive regulatory roles during skeletal myogenesis.	RSPO3 RSPO1	6.25e-07	2	28	2	21252233
Pubmed	LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling.	RSPO3 RSPO1	6.25e-07	2	28	2	21909076
Pubmed	Rspo1 and Rspo3 are required for sensory lineage neural crest formation in mouse embryos.	RSPO3 RSPO1	6.25e-07	2	28	2	37767857
Pubmed	Recurrent R-spondin fusions in colon cancer.	RSPO3 RSPO1	1.87e-06	3	28	2	22895193
Pubmed	R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis.	RSPO3 RSPO1	1.87e-06	3	28	2	15469841
Pubmed	RSPOs facilitated HSC activation and promoted hepatic fibrogenesis.	RSPO3 RSPO1	1.87e-06	3	28	2	27572318
Pubmed	Dynamic expression of R-spondin family genes in mouse development.	RSPO3 RSPO1	3.75e-06	4	28	2	17035101
Pubmed	Mesenchyme governs hair follicle induction.	RSPO3 RSPO1	3.75e-06	4	28	2	37982496
Pubmed	A conditional allele of Rspo3 reveals redundant function of R-spondins during mouse limb development.	RSPO3 RSPO1	3.75e-06	4	28	2	22610508
Pubmed	R-spondin-3 induces secretory, antimicrobial Lgr5+ cells in the stomach.	RSPO3 RSPO1	3.75e-06	4	28	2	31235935
Pubmed	LGR6 is a high affinity receptor of R-spondins and potentially functions as a tumor suppressor.	RSPO3 RSPO1	6.24e-06	5	28	2	22615920
Pubmed	Novel PRD-like homeodomain transcription factors and retrotransposon elements in early human development.	CPHXL CPHXL2	6.24e-06	5	28	2	26360614
Pubmed	Reconstitution of R-spondin:LGR4:ZNRF3 adult stem cell growth factor signaling complexes with recombinant proteins produced in Escherichia coli.	RSPO3 RSPO1	9.36e-06	6	28	2	24050775
Pubmed	Engineering high-potency R-spondin adult stem cell growth factors.	RSPO3 RSPO1	9.36e-06	6	28	2	25504990
Pubmed	Differential activities and mechanisms of the four R-spondins in potentiating Wnt/β-catenin signaling.	RSPO3 RSPO1	1.31e-05	7	28	2	29752411
Pubmed	Spatiotemporal expression patterns of R-spondins and their receptors, Lgrs, in the developing mouse telencephalon.	RSPO3 RSPO1	1.31e-05	7	28	2	37651925
Pubmed	R-spondins/Lgrs expression in tooth development.	RSPO3 RSPO1	1.74e-05	8	28	2	24616052
Pubmed	Mouse cristin/R-spondin family proteins are novel ligands for the Frizzled 8 and LRP6 receptors and activate beta-catenin-dependent gene expression.	RSPO3 RSPO1	2.24e-05	9	28	2	16543246
Pubmed	Secreted factor R-Spondin 2 is involved in refinement of patterning of the mammalian cochlea.	RSPO3 RSPO1	2.80e-05	10	28	2	23192966
Pubmed	Role of LGR5-positive mesenchymal cells in craniofacial development.	RSPO3 RSPO1	3.42e-05	11	28	2	36133922
Pubmed	R-Spondin 3 Regulates Mammalian Dental and Craniofacial Development.	RSPO3 RSPO1	4.10e-05	12	28	2	34449628
Pubmed	The Matricellular Protein R-Spondin 2 Promotes Midbrain Dopaminergic Neurogenesis and Differentiation.	RSPO3 RSPO1	4.10e-05	12	28	2	30146491
Pubmed	RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6.	RSPO3 RSPO1	4.10e-05	12	28	2	29769720
Pubmed	The adrenal capsule is a signaling center controlling cell renewal and zonation through Rspo3.	RSPO3 RSPO1	4.85e-05	13	28	2	27313319
Pubmed	Id2 controls specification of Lgr5+ intestinal stem cell progenitors during gut development.	RSPO3 RSPO1	6.52e-05	15	28	2	28077488
Pubmed	A brain precursor atlas reveals the acquisition of developmental-like states in adult cerebral tumours.	RSPO3 RSPO1	7.45e-05	16	28	2	35853870
Pubmed	Mesenchymal-epithelial crosstalk shapes intestinal regionalisation via Wnt and Shh signalling.	RSPO3 RSPO1	7.45e-05	16	28	2	35132078
Pubmed	The Angiocrine Factor Rspondin3 Is a Key Determinant of Liver Zonation.	RSPO3 RSPO1	1.30e-04	21	28	2	26655896
Pubmed	LGR5 controls extracellular matrix production by stem cells in the developing intestine.	RSPO3 RSPO1	1.56e-04	23	28	2	32468660
Pubmed	Neonatal Wnt-dependent Lgr5 positive stem cells are essential for uterine gland development.	RSPO3 RSPO1	1.71e-04	24	28	2	31772170
Pubmed	Human ATAC Is a GCN5/PCAF-containing acetylase complex with a novel NC2-like histone fold module that interacts with the TATA-binding protein.	WDR5 USP22	2.17e-04	27	28	2	18838386
Pubmed	Signalling codes for the maintenance and lineage commitment of embryonic gastric epithelial progenitors.	RSPO3 RSPO1	2.17e-04	27	28	2	32878924
Pubmed	CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation.	WDR5 WDR5B	2.33e-04	28	28	2	17041588
Pubmed	Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury.	RSPO3 RSPO1	2.50e-04	29	28	2	22956684
Pubmed	Genetic interactions of the androgen and Wnt/beta-catenin pathways for the masculinization of external genitalia.	RSPO3 RSPO1	2.68e-04	30	28	2	19282366
Pubmed	Atlas of Wnt and R-spondin gene expression in the developing male mouse lower urogenital tract.	RSPO3 RSPO1	2.68e-04	30	28	2	21936019
Pubmed	R-spondin signalling is essential for the maintenance and differentiation of mouse nephron progenitors.	RSPO3 RSPO1	2.68e-04	30	28	2	32324134
Pubmed	Single cell and genetic analyses reveal conserved populations and signaling mechanisms of gastrointestinal stromal niches.	RSPO3 RSPO1	2.68e-04	30	28	2	31953387
Pubmed	Defining developmental diversification of diencephalon neurons through single cell gene expression profiling.	RSPO3 RSPO1	2.86e-04	31	28	2	30872278
Pubmed	Postnatal prolongation of mammalian nephrogenesis by excess fetal GDNF.	RSPO3 RSPO1	3.66e-04	35	28	2	34032268
Pubmed	Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development.	RSPO3 RSPO1	3.87e-04	36	28	2	24151333
Pubmed	Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells.	ZNF555 ZNF440 ZNF77	4.13e-04	181	28	3	37372979
Pubmed	ATAC and SAGA co-activator complexes utilize co-translational assembly, but their cellular localization properties and functions are distinct.	WDR5 USP22	5.79e-04	44	28	2	37682711
Pubmed	Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis.	RSPO3 RSPO1	6.61e-04	47	28	2	28813421
Pubmed	Transcriptional analysis of Gli3 mutants identifies Wnt target genes in the developing hippocampus.	RSPO3 RSPO1	6.61e-04	47	28	2	22235033
Interaction	ZNF763 interactions	ZNF69 ZNF763	2.39e-05	6	26	2	int:ZNF763
Cytoband	Ensembl 112 genes in cytogenetic band chr19p13	ZNF69 ZNF555 ZNF763 ZNF439 ZNF440 ZNF77	7.31e-06	797	28	6	chr19p13
Cytoband	19p13.2	ZNF69 ZNF763 ZNF439 ZNF440	1.12e-05	229	28	4	19p13.2
Cytoband	Ensembl 112 genes in cytogenetic band chr16q23	ADAMTS18 CPHXL CPHXL2	4.92e-05	116	28	3	chr16q23
Cytoband	19p13.3	ZNF555 ZNF77	9.18e-03	237	28	2	19p13.3
GeneFamily	Zinc fingers C2H2-type\|ZF class homeoboxes and pseudogenes	ZSCAN29 ZNF449 ZNF69 ZNF772 ZNF555 ZNF763 ZNF439 ZNF879 ZNF596 ZNF440 ZNF77	1.70e-10	718	22	11	28
Coexpression	GSE2706_UNSTIM_VS_2H_LPS_DC_UP	ZSCAN29 ZNF449 ZNF555 ZNF439 ZNF879	1.32e-06	197	26	5	M4695
Coexpression	GSE15659_CD45RA_NEG_CD4_TCELL_VS_RESTING_TREG_DN	ZSCAN29 ZNF277 ZNF596 ZCCHC13	4.15e-05	198	26	4	M3552
Coexpression	GSE15659_NAIVE_CD4_TCELL_VS_ACTIVATED_TREG_DN	ZSCAN29 ZNF277 ZNF596 ZCCHC13	4.15e-05	198	26	4	M3550
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-bronchial_smooth_muscle_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF449 RSPO3 DGKB RIMS1	5.71e-06	189	28	4	4dc32b463546bbe7250dddd281b92ad17ec22da1
ToppCell	droplet-Lung-LUNG-1m-Mesenchymal-Airway_Smooth_Muscle\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ZNF449 RSPO3 DGKB RIMS1	5.71e-06	189	28	4	0d06bf0d7191d13a1c4f30a7881e7ea1093bfd6f
Disease	Premature atrial contractions	ZNF69 ZNF440	8.42e-04	55	23	2	HP_0006699
Disease	congenital heart disease (implicated_via_orthology)	WDR5 WDR5B	1.32e-03	69	23	2	DOID:1682 (implicated_via_orthology)
Disease	nicotine dependence symptom count	ADAMTS18 DGKB RIMS1	1.37e-03	285	23	3	EFO_0009262
Disease	DNA methylation	ADAMTS18 FAT4 RIMS1 ZNF596	1.53e-03	656	23	4	GO_0006306
Disease	total cortical area measurement	ADAMTS18 RSPO3	2.43e-03	94	23	2	EFO_0008381
Disease	spine bone mineral density	RSPO3 DGKB	3.86e-03	119	23	2	EFO_0007701
Disease	cup-to-disc ratio measurement	RSPO3 DGKB FAT4	4.38e-03	430	23	3	EFO_0006939

Protein segments in the cluster

Peptide	Gene	Start	Entry
CHCKEGLTGKYCEKS	FAT4	4186	Q6V0I7
HKFYGKQCCKSCTRK	ADAMTS18	1206	Q8TE60
CGAHRNYKKLLGSCC	HIRIP3	436	Q9BW71
CCKHCHTKLSLGSYA	LIMD2	66	Q9BT23
KTKFADGCGHLCSYC	RIMS1	121	Q86UR5
YGVKKDHCLCSFCLS	CPHXL2	261	A0A1W2PPK0
CDKCHKTVKCYQGLT	DGKB	321	Q9Y6T7
KACYHKACFKSGSCP	RUBCN	916	Q92622
AYGVKKDHCLCSFCL	CPHXL	286	A0A1W2PPM1
CTKCKEGLYLHKGRC	RSPO1	111	Q2MKA7
GKLRKPCYCGAKSCT	SETMAR	281	Q53H47
KCKFCGKAFHCLRLY	ZNF440	201	Q8IYI8
CLYCVFFGCFTKKHI	USP22	76	Q9UPT9
KCLKTLKGHSNYVFC	WDR5B	116	Q86VZ2
CKHCGKAFTCYSSLR	ZNF77	326	Q15935
ECKLCGKAFYCHISL	ZNF555	481	Q8NEP9
PYGCLLCGKAFSKCS	ZNF596	306	Q8TC21
CTKCKSGFYLHLGKC	RSPO3	111	Q9BXY4
KCYSCGKLGHIQKDC	ZCCHC13	111	Q8WW36
QCRCYGCHVKFKSKA	ZNF277	356	Q9NRM2
RKCYKCNICGKIFLH	ZNF879	201	B4DU55
KCKFCGKAFHCLSLY	ZNF69	221	Q9UC07
KPYGCHDCGKCFSKS	ZSCAN29	816	Q8IWY8
KCKFCGKAVHCLRLY	ZNF763	201	Q0D2J5
CGKRHYKCSECGKTF	ZNF772	261	Q68DY9
CLKTLKGHSNYVFCC	WDR5	121	P61964
TYKCLECGKSFCHGS	ZNF449	406	Q6P9G9
CKFCGKAFHCLSLYL	ZNF439	216	Q8NDP4