Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	growth factor activity	INHBE GDF7 GDF15 GDF6 GDF2 GDF11	2.72e-05	173	68	6	GO:0008083
GeneOntologyMolecularFunction	cytokine activity	INHBE GDF7 GDF15 GDF6 GDF2 GDF11	2.07e-04	250	68	6	GO:0005125
GeneOntologyMolecularFunction	hyalurononglucosaminidase activity	HYAL1 HYAL3	4.05e-04	9	68	2	GO:0004415
GeneOntologyMolecularFunction	myosin II binding	TRIOBP GSN	8.70e-04	13	68	2	GO:0045159
GeneOntologyMolecularFunction	actin filament binding	TRIOBP GAS7 NEB NEXN GSN	1.06e-03	227	68	5	GO:0051015
GeneOntologyMolecularFunction	hexosaminidase activity	HYAL1 HYAL3	1.50e-03	17	68	2	GO:0015929
GeneOntologyMolecularFunction	virus receptor activity	SELPLG HYAL1 HYAL3	3.06e-03	85	68	3	GO:0001618
GeneOntologyMolecularFunction	exogenous protein binding	SELPLG HYAL1 HYAL3	3.16e-03	86	68	3	GO:0140272
GeneOntologyMolecularFunction	cullin family protein binding	DCUN1D5 DCUN1D4	3.52e-03	26	68	2	GO:0097602
GeneOntologyMolecularFunction	mitogen-activated protein kinase kinase kinase binding	DIXDC1 MAP4K2	3.52e-03	26	68	2	GO:0031435
GeneOntologyBiologicalProcess	regulation of SMAD protein signal transduction	GDF7 GDF15 GDF6 LRP1 GDF2 GDF11	5.13e-07	90	68	6	GO:0060390
GeneOntologyBiologicalProcess	SMAD protein signal transduction	GDF7 GDF15 GDF6 LRP1 GDF2 GDF11	1.68e-06	110	68	6	GO:0060395
GeneOntologyBiologicalProcess	positive regulation of SMAD protein signal transduction	GDF7 GDF6 GDF2 GDF11	1.21e-05	43	68	4	GO:0060391
GeneOntologyBiologicalProcess	activin receptor signaling pathway	GDF7 GDF6 GDF2 GDF11	4.58e-05	60	68	4	GO:0032924
GeneOntologyBiologicalProcess	positive regulation of protein neddylation	DCUN1D5 DCUN1D4	1.06e-04	5	68	2	GO:2000436
GeneOntologyBiologicalProcess	extracellular matrix disassembly	TPSAB1 ETS1 LRP1 GSN	1.10e-04	75	68	4	GO:0022617
MousePheno	impaired neutrophil chemotaxis	SELPLG TPSAB1 NLRP12 GSN STAT6	7.83e-07	40	61	5	MP:0008720
Domain	TGF-beta-rel	INHBE GDF7 GDF15 GDF6 GDF2 GDF11	1.30e-09	32	66	6	IPR015615
Domain	TGFB	INHBE GDF7 GDF15 GDF6 GDF2 GDF11	3.29e-09	37	66	6	SM00204
Domain	TGF-b_C	INHBE GDF7 GDF15 GDF6 GDF2 GDF11	3.29e-09	37	66	6	IPR001839
Domain	TGF_BETA_2	INHBE GDF7 GDF15 GDF6 GDF2 GDF11	3.29e-09	37	66	6	PS51362
Domain	TGF_beta	INHBE GDF7 GDF15 GDF6 GDF2 GDF11	3.29e-09	37	66	6	PF00019
Domain	TGF_BETA_1	INHBE GDF7 GDF15 GDF6 GDF2 GDF11	3.29e-09	37	66	6	PS00250
Domain	TGFb_propeptide	INHBE GDF7 GDF6 GDF2 GDF11	4.36e-08	28	66	5	PF00688
Domain	TGF-b_N	INHBE GDF7 GDF6 GDF2 GDF11	4.36e-08	28	66	5	IPR001111
Domain	TGFb_CS	INHBE GDF7 GDF6 GDF2 GDF11	8.83e-08	32	66	5	IPR017948
Domain	-	INHBE GDF7 GDF15 GDF6 GDF2 GDF11	1.30e-07	67	66	6	2.10.90.10
Domain	Cystine-knot_cytokine	INHBE GDF7 GDF15 GDF6 GDF2 GDF11	1.30e-07	67	66	6	IPR029034
Domain	DCN-prot	DCUN1D5 DCUN1D4	1.22e-04	5	66	2	IPR014764
Domain	Hyaluronidase	HYAL1 HYAL3	1.22e-04	5	66	2	IPR018155
Domain	PONY_dom	DCUN1D5 DCUN1D4	1.22e-04	5	66	2	IPR005176
Domain	Glyco_hydro_56	HYAL1 HYAL3	1.22e-04	5	66	2	PF01630
Domain	DCUN1	DCUN1D5 DCUN1D4	1.22e-04	5	66	2	PS51229
Domain	Cullin_binding	DCUN1D5 DCUN1D4	1.22e-04	5	66	2	PF03556
Domain	MA3	EIF4G1 EIF4G3	1.83e-04	6	66	2	SM00544
Domain	MA3	EIF4G1 EIF4G3	1.83e-04	6	66	2	PF02847
Domain	MI	EIF4G1 EIF4G3	1.83e-04	6	66	2	PS51366
Domain	Initiation_fac_eIF4g_MI	EIF4G1 EIF4G3	1.83e-04	6	66	2	IPR003891
Domain	eIF5C	EIF4G1 EIF4G3	2.55e-04	7	66	2	SM00515
Domain	W2	EIF4G1 EIF4G3	2.55e-04	7	66	2	PF02020
Domain	W2	EIF4G1 EIF4G3	2.55e-04	7	66	2	PS51363
Domain	W2_domain	EIF4G1 EIF4G3	2.55e-04	7	66	2	IPR003307
Domain	MIF4G	EIF4G1 EIF4G3	5.43e-04	10	66	2	SM00543
Domain	MIF4G	EIF4G1 EIF4G3	5.43e-04	10	66	2	PF02854
Domain	MIF4G-like_typ-3	EIF4G1 EIF4G3	5.43e-04	10	66	2	IPR003890
Domain	Glycoside_hydrolase_SF	HYAL1 HYAL3 SI	8.70e-04	53	66	3	IPR017853
Domain	Inhibin_asu	INHBE GDF2	9.36e-04	13	66	2	IPR002405
Domain	MIF4-like	EIF4G1 EIF4G3	1.25e-03	15	66	2	IPR016021
Domain	-	EIF4G1 EIF4G3	1.25e-03	15	66	2	1.25.40.180
Domain	TRYPSIN_SER	TPSAB1 PRSS36 TPSB2	3.98e-03	90	66	3	IPR033116
Domain	Ig_I-set	ROBO4 SIGLEC10 KIRREL2 NEXN	4.58e-03	190	66	4	IPR013098
Domain	I-set	ROBO4 SIGLEC10 KIRREL2 NEXN	4.58e-03	190	66	4	PF07679
Domain	Abhydrolase_1	EPHX1 LIPM	5.35e-03	31	66	2	PF00561
Domain	TRYPSIN_HIS	TPSAB1 PRSS36 TPSB2	5.80e-03	103	66	3	IPR018114
Domain	AB_hydrolase_1	EPHX1 LIPM	6.05e-03	33	66	2	IPR000073
Domain	TRYPSIN_SER	TPSAB1 PRSS36 TPSB2	6.27e-03	106	66	3	PS00135
Domain	TRYPSIN_HIS	TPSAB1 PRSS36 TPSB2	6.44e-03	107	66	3	PS00134
Domain	Peptidase_S1A	TPSAB1 PRSS36 TPSB2	7.48e-03	113	66	3	IPR001314
Domain	TRYPSIN_DOM	TPSAB1 PRSS36 TPSB2	7.85e-03	115	66	3	PS50240
Domain	Tryp_SPc	TPSAB1 PRSS36 TPSB2	8.23e-03	117	66	3	SM00020
Pubmed	TGFbeta superfamily signals are required for morphogenesis of the kidney mesenchyme progenitor population.	INHBE GDF7 GDF15 GDF6 GDF2 GDF11	1.31e-09	55	69	6	15342483
Pubmed	Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.	GPRASP1 ARHGEF9 GAS7 ZZEF1 PLXNB1	6.41e-08	52	69	5	9455477
Pubmed	Regulation of hyaluronidase activity by alternative mRNA splicing.	HYAL1 HYAL3	3.88e-06	2	69	2	12084718
Pubmed	Growth Differentiation Factor 15 Mediates Systemic Glucose Regulatory Action of T-Helper Type 2 Cytokines.	GDF15 STAT6	3.88e-06	2	69	2	28874416
Pubmed	The structure of the human betaII-tryptase tetramer: fo(u)r better or worse.	TPSAB1 TPSB2	3.88e-06	2	69	2	10500112
Pubmed	Mutations in HYAL1, a member of a tandemly distributed multigene family encoding disparate hyaluronidase activities, cause a newly described lysosomal disorder, mucopolysaccharidosis IX.	HYAL1 HYAL3	3.88e-06	2	69	2	10339581
Pubmed	Characterization of a tryptase mRNA expressed in the human basophil cell line KU812.	TPSAB1 TPSB2	3.88e-06	2	69	2	8434231
Pubmed	BMP12 and BMP13 gene transfer induce ligamentogenic differentiation in mesenchymal progenitor and anterior cruciate ligament cells.	GDF7 GDF6	3.88e-06	2	69	2	20334610
Pubmed	Cloning and characterization of a second complementary DNA for human tryptase.	TPSAB1 TPSB2	3.88e-06	2	69	2	2203827
Pubmed	Characterization of two highly polymorphic human tryptase loci and comparison with a newly discovered monkey tryptase ortholog.	TPSAB1 TPSB2	3.88e-06	2	69	2	10898108
Pubmed	Nexilin Is Necessary for Maintaining the Transverse-Axial Tubular System in Adult Cardiomyocytes.	A1CF NEXN	3.88e-06	2	69	2	32635769
Pubmed	Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions.	EIF4G1 EIF4G3	3.88e-06	2	69	2	31999954
Pubmed	STAT6 and LRP1 polymorphisms are associated with food allergen sensitization in Mexican children.	LRP1 STAT6	3.88e-06	2	69	2	22534531
Pubmed	Human beta-tryptase is a ring-like tetramer with active sites facing a central pore.	TPSAB1 TPSB2	3.88e-06	2	69	2	9521329
Pubmed	eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation.	EIF4G1 EIF4G3	3.88e-06	2	69	2	10872469
Pubmed	Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family.	TPSAB1 TPSB2	3.88e-06	2	69	2	2187193
Pubmed	Structural requirements and mechanism for heparin-dependent activation and tetramerization of human betaI- and betaII-tryptase.	TPSAB1 TPSB2	3.88e-06	2	69	2	15567416
Pubmed	Hyal-1 but not Hyal-3 deficiency has an impact on ovarian folliculogenesis and female fertility by altering the follistatin/activin/Smad3 pathway and the apoptotic process.	HYAL1 HYAL3	3.88e-06	2	69	2	21732362
Pubmed	Human tryptases alpha and beta/II are functionally distinct due, in part, to a single amino acid difference in one of the surface loops that forms the substrate-binding cleft.	TPSAB1 TPSB2	3.88e-06	2	69	2	10391906
Pubmed	The human mast cell tryptase tetramer: a fascinating riddle solved by structure.	TPSAB1 TPSB2	3.88e-06	2	69	2	10708850
Pubmed	Tryptase haplotype in mastocytosis: relationship to disease variant and diagnostic utility of total tryptase levels.	TPSAB1 TPSB2	3.88e-06	2	69	2	17449330
Pubmed	STAT6 and Ets-1 form a stable complex that modulates Socs-1 expression by interleukin-4 in keratinocytes.	ETS1 STAT6	3.88e-06	2	69	2	15199062
Pubmed	Impact of naturally forming human α/β-tryptase heterotetramers in the pathogenesis of hereditary α-tryptasemia.	TPSAB1 TPSB2	3.88e-06	2	69	2	31337736
Pubmed	Bone Morphogenetic Protein 9 and 13 Induce C3H10T1/2 Cell Differentiation to Cardiomyocyte-Like Cells In Vitro.	GDF6 GDF2	3.88e-06	2	69	2	24380493
Pubmed	Animal Models of Congenital Cardiomyopathies Associated With Mutations in Z-Line Proteins.	A1CF NEB NEXN	7.08e-06	19	69	3	27171814
Pubmed	Transforming growth factor-β superfamily ligand trap ACE-536 corrects anemia by promoting late-stage erythropoiesis.	INHBE GDF11	1.16e-05	3	69	2	24658078
Pubmed	Structural characterization of the Z RING-eIF4E complex reveals a distinct mode of control for eIF4E.	EIF4G1 EIF4G3	1.16e-05	3	69	2	20212144
Pubmed	Involvement of hyaluronidases in colorectal cancer.	HYAL1 HYAL3	1.16e-05	3	69	2	20849597
Pubmed	Crosstalk of HDAC4, PP1, and GSDMD in controlling pyroptosis.	GSDMD PPP1CC	1.16e-05	3	69	2	38326336
Pubmed	Expression and regulation patterns of hyaluronidases in small cell lung cancer and glioma lines.	HYAL1 HYAL3	1.16e-05	3	69	2	12684632
Pubmed	Plasma Gelsolin Reinforces the Diagnostic Value of FGF-21 and GDF-15 for Mitochondrial Disorders.	GDF15 GSN	1.16e-05	3	69	2	34203775
Pubmed	Expression and cellular localization of human hyaluronidase-2 in articular chondrocytes and cultured cell lines.	HYAL1 HYAL3	1.16e-05	3	69	2	16600643
Pubmed	Ultraviolet-B irradiation induces differential regulations of hyaluronidase expression and activity in normal human keratinocytes.	HYAL1 HYAL3	1.16e-05	3	69	2	21699545
Pubmed	Regulation of MDMX expression by mitogenic signaling.	ETS1 MDM4	1.16e-05	3	69	2	18172009
Pubmed	Mammalian hyaluronidase induces ovarian granulosa cell apoptosis and is involved in follicular atresia.	HYAL1 HYAL3	1.16e-05	3	69	2	18653706
Pubmed	Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine.	LRP1 STAT6	1.16e-05	3	69	2	27322543
Pubmed	Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3.	TPSAB1 TPSB2	1.16e-05	3	69	2	9920877
Pubmed	Hyaluronidase expression and activity is regulated by pro-inflammatory cytokines in human airway epithelial cells.	HYAL1 HYAL3	1.16e-05	3	69	2	18390475
Pubmed	A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation.	EIF4G1 EIF4G3	1.16e-05	3	69	2	9857202
Pubmed	Isolation of zebrafish gdf7 and comparative genetic mapping of genes belonging to the growth/differentiation factor 5, 6, 7 subgroup of the TGF-beta superfamily.	GDF7 GDF6	1.16e-05	3	69	2	10022976
Pubmed	Candidate tumor suppressor HYAL2 is a glycosylphosphatidylinositol (GPI)-anchored cell-surface receptor for jaagsiekte sheep retrovirus, the envelope protein of which mediates oncogenic transformation.	HYAL1 HYAL3	1.16e-05	3	69	2	11296287
Pubmed	Divergent activities of osteogenic BMP2, and tenogenic BMP12 and BMP13 independent of receptor binding affinities.	GDF7 GDF6	1.16e-05	3	69	2	21702718
Pubmed	Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations.	TPSAB1 TPSB2	1.16e-05	3	69	2	19748655
Pubmed	Expression and activity of hyaluronidases HYAL-1, HYAL-2 and HYAL-3 in the human intervertebral disc.	HYAL1 HYAL3	1.16e-05	3	69	2	31758257
Pubmed	A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.	SART1 MAGED1 EIF4G1 TRIOBP EIF4G3 PRPF8 DYSF GSN PPP1CC	1.30e-05	724	69	9	36232890
Pubmed	CD44-dependent intracellular and extracellular catabolism of hyaluronic acid by hyaluronidase-1 and -2.	HYAL1 HYAL3	2.32e-05	4	69	2	17170110
Pubmed	Cardiac-specific deletion of protein phosphatase 1β promotes increased myofilament protein phosphorylation and contractile alterations.	A1CF PPP1CC	2.32e-05	4	69	2	26334248
Pubmed	Hyaluronidases and CD44 undergo differential modulation during chondrogenesis.	HYAL1 HYAL3	2.32e-05	4	69	2	11944887
Pubmed	Protein phosphatase 1 inhibits p53 signaling by dephosphorylating and stabilizing Mdmx.	MDM4 PPP1CC	2.32e-05	4	69	2	23277204
Pubmed	PRPF19 regulates p53-dependent cellular senescence by modulating alternative splicing of MDM4 mRNA.	MDM4 PRPF8	2.32e-05	4	69	2	34144037
Pubmed	Reversing chemoresistance by small molecule inhibition of the translation initiation complex eIF4F.	EIF4G1 EIF4G3	2.32e-05	4	69	2	21191102
Pubmed	The 65 and 110 kDa SR-related proteins of the U4/U6.U5 tri-snRNP are essential for the assembly of mature spliceosomes.	SART1 PRPF8	3.86e-05	5	69	2	11350945
Pubmed	Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E.	EIF4G1 EIF4G3	3.86e-05	5	69	2	9878069
Pubmed	Characterization of human gamma-tryptases, novel members of the chromosome 16p mast cell tryptase and prostasin gene families.	TPSAB1 TPSB2	3.86e-05	5	69	2	10843716
Pubmed	structural Studies of Wnts and identification of an LRP6 binding site.	GDF15 STAT6	3.86e-05	5	69	2	23791946
Pubmed	Regulation of translation initiation in eukaryotes: mechanisms and biological targets.	EIF4G1 EIF4G3	3.86e-05	5	69	2	19239892
Pubmed	A novel functional human eukaryotic translation initiation factor 4G.	EIF4G1 EIF4G3	3.86e-05	5	69	2	9418880
Pubmed	Cutting Edge: The Heat Shock Protein gp96 Activates Inflammasome-Signaling Platforms in APCs.	GSDMD LRP1	3.86e-05	5	69	2	30209191
Pubmed	Reduced oxidative capacity in macrophages results in systemic insulin resistance.	GDF15 STAT6	3.86e-05	5	69	2	29674655
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	GPRASP1 FOXRED1 MAGED1 EIF4G1 LRP1 TRIOBP GAS7 EIF4G3 PRPF8 BRWD3 STAT6	4.28e-05	1285	69	11	35914814
Pubmed	Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3.	HYAL1 HYAL3	5.79e-05	6	69	2	11929860
Pubmed	ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors.	A1CF LRP1	5.79e-05	6	69	2	27400128
Pubmed	New developments in the genetics and activation of mast cell proteases.	TPSAB1 TPSB2	5.79e-05	6	69	2	12217407
Pubmed	eIF4GI links nutrient sensing by mTOR to cell proliferation and inhibition of autophagy.	EIF4G1 EIF4G3	5.79e-05	6	69	2	18426977
Pubmed	Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo.	EIF4G1 EIF4G3	5.79e-05	6	69	2	10022874
Pubmed	Neuronal differentiation of precursors in the neocortical ventricular zone is triggered by BMP.	GDF7 GDF6	8.09e-05	7	69	2	9786991
Pubmed	Skeletal and hematological anomalies in HYAL2-deficient mice: a second type of mucopolysaccharidosis IX?	HYAL1 HYAL3	8.09e-05	7	69	2	18772348
Pubmed	Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily.	GDF7 GDF6	8.09e-05	7	69	2	8145850
Pubmed	The conserved protein DCN-1/Dcn1p is required for cullin neddylation in C. elegans and S. cerevisiae.	DCUN1D5 DCUN1D4	8.09e-05	7	69	2	15988528
Pubmed	Multiple joint and skeletal patterning defects caused by single and double mutations in the mouse Gdf6 and Gdf5 genes.	GDF7 GDF6	8.09e-05	7	69	2	12606286
Pubmed	N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.	SART1 GSDMD EIF4G1 TRIOBP MAP4K2 GSN	8.17e-05	360	69	6	33111431
Pubmed	Identification and quantification of the basal and inducible Nrf2-dependent proteomes in mouse liver: biochemical, pharmacological and toxicological implications.	EPHX1 ENTPD5	1.08e-04	8	69	2	24859727
Pubmed	Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses.	GDF7 GDF6	1.08e-04	8	69	2	16049014
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	SART1 GPRASP1 MAGED1 EIF4G1 LRP1 TRIOBP DIXDC1 GSN PPP1CC	1.18e-04	963	69	9	28671696
Pubmed	eIF4G is required for the pioneer round of translation in mammalian cells.	EIF4G1 EIF4G3	1.38e-04	9	69	2	15361857
Pubmed	Dynamin genes Dnm1 and Dnm2 are located on proximal mouse chromosomes 2 and 9, respectively.	ETS1 NEB	1.38e-04	9	69	2	9143510
Pubmed	A human FLII gene variant alters sarcomeric actin thin filament length and predisposes to cardiomyopathy.	A1CF GSN	1.38e-04	9	69	2	37126682
Pubmed	Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.	ROBO4 ENTPD5 LRP1 MINPP1 PLXNB1	1.62e-04	257	69	5	16335952
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	ARHGAP6 MAGED1 AEBP1 NFKBIL1 EIF4G3 MDM4	2.14e-04	430	69	6	35044719
Pubmed	A large-scale candidate gene association study of age at menarche and age at natural menopause.	INHBE GDF7 GDF6 GDF2 GDF11	2.22e-04	275	69	5	20734064
Pubmed	Neuronal patterning by BMPs: a requirement for GDF7 in the generation of a discrete class of commissural interneurons in the mouse spinal cord.	GDF7 GDF6	2.53e-04	12	69	2	9808626
Pubmed	Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.	LRP1 TRIOBP NEXN GSN PPP1CC	2.61e-04	285	69	5	21423176
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	WWC2 AOPEP CEP162 ETS1 MASTL NEXN PLXNB1 SERTAD3 STAT6	2.84e-04	1084	69	9	11544199
Pubmed	The mouse homeobox gene Noto regulates node morphogenesis, notochordal ciliogenesis, and left right patterning.	DYNC2H1 NOTO	2.98e-04	13	69	2	17884984
Pubmed	Structural conservation of distinctive N-terminal acetylation-dependent interactions across a family of mammalian NEDD8 ligation enzymes.	DCUN1D5 DCUN1D4	2.98e-04	13	69	2	23201271
Pubmed	Genome-wide chromatin accessibility and transcriptome profiling show minimal epigenome changes and coordinated transcriptional dysregulation of hedgehog signaling in Danforth's short tail mice.	NOTO KIRREL2	2.98e-04	13	69	2	30380057
Pubmed	The network of protein-protein interactions within the human U4/U6.U5 tri-snRNP.	SART1 PRPF8	2.98e-04	13	69	2	16723661
Pubmed	Opposing Effects of Growth and Differentiation Factors in Cell-Fate Specification.	GDF15 GDF11	2.98e-04	13	69	2	31155355
Pubmed	Human U4/U6.U5 and U4atac/U6atac.U5 tri-snRNPs exhibit similar protein compositions.	SART1 PRPF8	3.48e-04	14	69	2	11971955
Pubmed	PTPN14 regulates Roquin2 stability by tyrosine dephosphorylation.	SART1 FOXRED1 MAGED1 EIF4G1 PRPF8 GSN PPP1CC	3.93e-04	678	69	7	30209976
Pubmed	SRF phosphorylation by glycogen synthase kinase-3 promotes axon growth in hippocampal neurons.	NEXN GSN	4.01e-04	15	69	2	24623780
Pubmed	Regulation of GDF-11 and myostatin activity by GASP-1 and GASP-2.	GPRASP1 GDF11	4.01e-04	15	69	2	24019467
Pubmed	The mRNA translation initiation factor eIF4G1 controls mitochondrial oxidative phosphorylation, axonal morphogenesis, and memory.	EIF4G1 EIF4G3	4.57e-04	16	69	2	37307456
Pubmed	Differential regulation of node formation, nodal ciliogenesis and cilia positioning by Noto and Foxj1.	DYNC2H1 NOTO	5.18e-04	17	69	2	22357932
Pubmed	Characterization of the mammalian family of DCN-type NEDD8 E3 ligases.	DCUN1D5 DCUN1D4	5.81e-04	18	69	2	26906416
Pubmed	Transcriptional regulatory network of SOX4 during myoblast differentiation.	MINPP1 PLXNB1	6.49e-04	19	69	2	25969425
Pubmed	RSPO-LGR4 functions via IQGAP1 to potentiate Wnt signaling.	EIF4G1 EIF4G3 PRPF8 NEXN	7.11e-04	202	69	4	24639526
Pubmed	Mdm4 controls ureteric bud branching via regulation of p53 activity.	GDF15 MDM4	7.95e-04	21	69	2	32464196
Pubmed	Genome-wide association study of ancestry-specific TB risk in the South African Coloured population.	DCUN1D5 DYNC2H1	7.95e-04	21	69	2	24057671
Pubmed	Temporomandibular joint formation requires two distinct hedgehog-dependent steps.	GDF7 GDF6	7.95e-04	21	69	2	19815519
Cytoband	Ensembl 112 genes in cytogenetic band chr12q13	CERS5 INHBE LRP1 GDF11 STAT6	4.49e-04	423	69	5	chr12q13
Cytoband	12q13.3	INHBE LRP1	2.71e-03	51	69	2	12q13.3
Cytoband	Ensembl 112 genes in cytogenetic band chr11q24	ROBO4 FOXRED1 ETS1	3.04e-03	191	69	3	chr11q24
ToppCell	10x5'-GI_large-bowel-Mast\|GI_large-bowel / Manually curated celltypes from each tissue	TPSAB1 ARHGAP6 TTLL9 HYAL1 GDF15 TPSB2	3.44e-07	178	69	6	d10ed2543c96e1a2373f847e0b82144771e26d07
ToppCell	10x5'-GI_large-bowel-Mast-Mast_cells\|GI_large-bowel / Manually curated celltypes from each tissue	TPSAB1 ARHGAP6 TTLL9 HYAL1 GDF15 TPSB2	3.44e-07	178	69	6	8fc5f735afa25ae43c2acb1c710ade6e9e093e3c
ToppCell	hematopoetic_progenitors-CD34+_MEP_1\|hematopoetic_progenitors / Lineage and Cell class	TPSAB1 ARHGAP6 HYAL3 SIGLEC10 MINPP1 TPSB2	6.22e-07	197	69	6	6172a1b98ff840d9174b1ab20ba0c202a7ef87af
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TPSAB1 GDF15 GAS7 DYSF TPSB2	7.72e-06	175	69	5	b2099b4ab1bf74497f454a99fffe5f5561b1f968
ToppCell	BAL-Mild-Myeloid-MoAM-MoAM4-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TPSAB1 GDF15 GAS7 DYSF TPSB2	7.72e-06	175	69	5	6e54b74c735f249c7bfab7087c1638065ec1dd2e
ToppCell	3'_v3-lymph-node_spleen-Mast-Mast_cell_lympho\|lymph-node_spleen / Manually curated celltypes from each tissue	TPSAB1 NLRP12 LRP1 SI TPSB2	8.16e-06	177	69	5	53040dbeb18574a48e352e4bce252c7c3018762c
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ROBO4 NEB DYSF MAP4K2 GSN	8.39e-06	178	69	5	60263c0bb9de3a57ba2ba543262a2ace0066fd85
ToppCell	3'_v3-blood-Hematopoietic_Erythro-Mega-Mega-Mast\|blood / Manually curated celltypes from each tissue	ARHGAP6 HYAL3 MINPP1 NEXN GSN	9.34e-06	182	69	5	1923b5669901f828e890416c22d1f1d21a4a2c6a
ToppCell	3'_v3-lymph-node_spleen-Hematopoietic_Erythro-Mega-Mega-Mast\|lymph-node_spleen / Manually curated celltypes from each tissue	ARHGAP6 HYAL3 MINPP1 NEXN GSN	1.09e-05	188	69	5	8e80e0714883e5c5e372d933682c5b55ebef7e62
ToppCell	facs-Lung-EPCAM-24m-Mesenchymal\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AEBP1 LRP1 GAS7 NEXN GSN	1.12e-05	189	69	5	324c81285c51f4f8bb1aef428b18fe2c549c2c11
ToppCell	facs-Lung-EPCAM-18m\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SELPLG AEBP1 LRP1 GAS7 GSN	1.24e-05	193	69	5	b9ac74357435f2f24aaede62b2a1d31b5d96a12c
ToppCell	3'-GW_trimst-1-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ROBO4 LIPM DYSF MAP4K2 GSN	1.24e-05	193	69	5	1b69f92c6a7a2516e393d3f3c371407ec791343d
ToppCell	3'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	EPHX1 ROBO4 HYAL1 DYSF MAP4K2	1.30e-05	195	69	5	36d4a11bc77a4cc97a22525c78ef8359f4a3ca66
ToppCell	Cerebellum-Endothelial\|Cerebellum / BrainAtlas - Mouse McCarroll V32	ARHGAP6 HYAL1 GSDMD ETS1 STAT6	1.30e-05	195	69	5	2192fd9b4682054776f0716933aed5a4a9412657
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	AEBP1 LRP1 GAS7 NEXN GSN	1.30e-05	195	69	5	47762d9e442fb1f6f0033e3e10f4c6e498d2c081
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TPSAB1 NLRP12 LRP1 GAS7 TPSB2	1.30e-05	195	69	5	391d8e00dd5f988baa6dbda8414d3c020679ea2f
ToppCell	droplet-Limb_Muscle-MUSCLE-30m-Mesenchymal\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AEBP1 LRP1 NEB NEXN GSN	1.30e-05	195	69	5	5c86fddd6d0530beecf45ea5ba6b823123847696
ToppCell	facs-Heart-LA\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAGED1 AEBP1 LRP1 GAS7 GSN	1.34e-05	196	69	5	8a84aeb1a565dd3e2a690fcaf1ab804f5e253545
ToppCell	facs-Trachea-24m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l20-25\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	AEBP1 LRP1 TRIOBP GAS7 GSN	1.34e-05	196	69	5	ed6047b48b6a96baa6a90c7af784e7c34b32824d
ToppCell	Parenchymal-NucSeq-Endothelial-Endothelia_vascular-VE_alveolar_capillary_Car4_aerocyte\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ROBO4 ARHGAP6 HYAL1 ETS1 DYSF	1.44e-05	199	69	5	dc88ce36cc066eb6c28cfd5b9b60fe07f8cc7b53
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Activated_Alv_Cap\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	ROBO4 HYAL1 GSDMD HELZ2 ETS1	1.47e-05	200	69	5	89821a264e872ed53e08e9d3609d5cc5c314503e
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGAP6 AEBP1 LRP1 GAS7 NEXN	1.47e-05	200	69	5	34f52003988ce6329d8deeee1ab875fa77e01e9d
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0\|CD8+_Cytotoxic_T-cell / Donor, Lineage, Cell class and subclass (all cells)	WWC2 FOXRED1 AEBP1 TTLL9	7.40e-05	144	69	4	57d2846ec26d4490ec11c171af447b17a729437e
ToppCell	PND10-Immune-Immune_Myeloid-Granulocytic\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SELPLG TPSAB1 NLRP12 TPSB2	8.45e-05	149	69	4	c9334f319a0c943268e54b6f0c9446736172c3a9
ToppCell	PND07-Immune-Immune_Myeloid-Granulocytic\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SELPLG TPSAB1 NLRP12 TPSB2	9.60e-05	154	69	4	f92d83c5f8b532fe5624f1cd352632f543d96ea9
ToppCell	TCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Clear_Cell_Renal_Carcinoma-1\|TCGA-Kidney / Sample_Type by Project: Shred V9	A1CF GDF6 ETS1 DYSF	1.14e-04	161	69	4	6cacae4a759ace763597ee394cff498dc5d96f74
ToppCell	Control-B_intermediate-10\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	WWC2 GAS7 NEB SERTAD3	1.17e-04	162	69	4	aa80452b972bb8ad3670ffaba4ce26fadb33b185
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Immune-Myeloid-Granulocytic-Mast_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	TPSAB1 GAS7 SI TPSB2	1.22e-04	164	69	4	2c48c6e4eeee845f0563982d0bfa2a176ca5ef61
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pou6f2-Inhibitory_Neuron.Gad1Gad2.Pou6f2-Pax6_(Zona_incerta_(ZI))\|Thalamus / BrainAtlas - Mouse McCarroll V32	GDF7 LIPM GDF2	1.22e-04	62	69	3	02f0398e18bd61fbfa03bce71ae77e106181abee
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pou6f2-Inhibitory_Neuron.Gad1Gad2.Pou6f2-Pax6_(Zona_incerta_(ZI))-\|Thalamus / BrainAtlas - Mouse McCarroll V32	GDF7 LIPM GDF2	1.22e-04	62	69	3	8fdbced7a2baa1bfb5b1e204128234424a872fe6
ToppCell	Thalamus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Pou6f2\|Thalamus / BrainAtlas - Mouse McCarroll V32	GDF7 LIPM GDF2	1.22e-04	62	69	3	ff68e007b8b2af4c7fb09139aed92e86907a05da
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Immune-Myeloid-Granulocytic-Mast_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TPSAB1 SIGLEC10 GAS7 TPSB2	1.31e-04	167	69	4	a813b95c2fafb638b249bc4fa4f708c6f39ad444
ToppCell	TCGA-Endometrium-Solid_Tissue_Normal-Endometrium_normal_tissue-Endometrium-7\|TCGA-Endometrium / Sample_Type by Project: Shred V9	GPRASP1 ARHGAP6 DIXDC1 NEXN	1.34e-04	168	69	4	a97e8e07ba949b30805aeed5f60fa5e092b9d3d4
ToppCell	10x5'v1-week_12-13-Myeloid_neutrophil-granulo-eo/baso/mast-eosinophil\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	TPSAB1 HYAL3 SIGLEC10 TPSB2	1.37e-04	169	69	4	f68195510b91e287fe1507455ca067ece77a3897
ToppCell	droplet-Lung-1m-Hematologic-myeloid-myeloid_dendritic_cell-proliferating_dendritic\|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TTLL9 ENTPD5 ARHGEF9 MASTL	1.40e-04	170	69	4	badbe200e9d5003d23d115955b10b4ea767f6c26
ToppCell	TCGA-Endometrium-Solid_Tissue_Normal-Endometrium_normal_tissue-Endometrium\|TCGA-Endometrium / Sample_Type by Project: Shred V9	GPRASP1 ARHGAP6 DIXDC1 NEXN	1.40e-04	170	69	4	cdc19013da7c41d1ed8400a6a643e4c684ff9912
ToppCell	TCGA-Endometrium-Solid_Tissue_Normal\|TCGA-Endometrium / Sample_Type by Project: Shred V9	GPRASP1 ARHGAP6 DIXDC1 NEXN	1.40e-04	170	69	4	0bde0a40440c7fdf7ba89cac8831d4014e7a4807
ToppCell	TCGA-Endometrium-Solid_Tissue_Normal-Endometrium_normal_tissue\|TCGA-Endometrium / Sample_Type by Project: Shred V9	GPRASP1 ARHGAP6 DIXDC1 NEXN	1.40e-04	170	69	4	516b38c4ecf6b0b04c5d4f80c510dcc00b328c6f
ToppCell	343B-Fibroblasts-Fibroblast-H\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	SELPLG GDF15 EIF4G3 TPSB2	1.47e-04	172	69	4	eb199c279fe8a2551121db37e9556893197d33ff
ToppCell	343B-Fibroblasts-Fibroblast-H-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	SELPLG GDF15 EIF4G3 TPSB2	1.47e-04	172	69	4	709c6b77a7a52b873eefb6caca28a41291d384af
ToppCell	5'-GW_trimst-2-SmallIntestine-Hematopoietic-Myeloid-CLC+_Mast_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TPSAB1 HYAL3 SIGLEC10 TPSB2	1.47e-04	172	69	4	2ab720a4c96073339a1f8b95ec7699682df98acf
ToppCell	10x3'2.3-week_12-13-Myeloid_neutrophil-granulo-eo/baso/mast-eosinophil\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	TPSAB1 HYAL3 SIGLEC10 TPSB2	1.50e-04	173	69	4	1e4afa020fae682521335b440ccd33c16f37156f
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP1-CAP1_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	SLC2A8 GDF15 GDF11 MAP4K2	1.50e-04	173	69	4	12f779b8dce79431b2d1002ba524dd3f9566aeb0
ToppCell	wk_15-18-Hematologic-Myeloid-Eosinophil\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	TPSAB1 HYAL3 SIGLEC10 TPSB2	1.50e-04	173	69	4	a85cead231e03945fabbc7762540ad21fe4299df
ToppCell	droplet-Lung-LUNG-1m-Myeloid-Proliferating_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTLL9 ENTPD5 ARHGEF9 MASTL	1.50e-04	173	69	4	15af4a0f7516dbf5c93ba66a19aca073ebe30d04
ToppCell	5'-GW_trimst-2-LymphNode-Hematopoietic-Myeloid-CLC+_Mast_cell\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TPSAB1 HYAL3 SIGLEC10 TPSB2	1.54e-04	174	69	4	36080fa12497faa752ff07ae52cd3864053eafef
ToppCell	10x3'2.3-week_17-19-Hematopoietic-HSC/MPP_and_pro-eo/baso/mast_precursor\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	TPSAB1 HYAL3 SIGLEC10 TPSB2	1.54e-04	174	69	4	64d13a7a9757e85f4f4af876c687dd18a7efa01a
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Neuronal-Neuron\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	SART1 GSDMD NEXN GSN	1.57e-04	175	69	4	2812ac2ef41d245db544697fb6da1883361c96e8
ToppCell	10x5'v1-week_17-19-Myeloid_neutrophil-granulo-eo/baso/mast-basophil\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	TPSAB1 HYAL3 SIGLEC10 TPSB2	1.57e-04	175	69	4	ba1befc4e5f0167452f9ceace39377d16136dfa9
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Hematopoietic-Myeloid-CLC+_Mast_cell\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SELPLG TPSAB1 SIGLEC10 TPSB2	1.60e-04	176	69	4	183ba1aa5cf594b88ec08e0e41241668b51256a9
ToppCell	3'_v3-blood-Mast-Mast_cell_granulo-myelo\|blood / Manually curated celltypes from each tissue	EPHX1 TPSAB1 SLC2A8 TPSB2	1.60e-04	176	69	4	d421b6b8e13894dbcf29548c0a6516c3dee8f9b1
ToppCell	5'-Adult-Appendix-Hematopoietic-Myeloid-cDC1\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GDF7 TTLL9 SIGLEC10 DYSF	1.64e-04	177	69	4	345cebc19f93970a9a46be139208b300081f5493
ToppCell	T_cells-ISG-high_CD4+_T_cells\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	GSDMD HELZ2 MASTL NEXN	1.71e-04	179	69	4	af35ef8a7768cee0c2af0590e5bec35cee6a4714
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ROBO4 HYAL1 DYSF MAP4K2	1.71e-04	179	69	4	abc6797bd3884aa75dca58fcb2523ee321243ab1
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ROBO4 HYAL1 DYSF MAP4K2	1.71e-04	179	69	4	0b996d6e881f31e6b80d359f7caac70ecdeb9982
ToppCell	10x3'2.3-week_14-16-Myeloid_neutrophil-granulo-eo/baso/mast-eosinophil\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	TPSAB1 HYAL3 SIGLEC10 TPSB2	1.71e-04	179	69	4	810972561d1ae5a68389b54ceeac7a49890513a4
ToppCell	P28-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	AEBP1 LRP1 GAS7 GSN	1.75e-04	180	69	4	9adebde5f4ca6dcb90e9113622862e14298465ac
ToppCell	Fetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	ROBO4 HELZ2 ETS1 DYSF	1.75e-04	180	69	4	d8ef44710a77ad0fc03243428e5e1dc4d41200cb
ToppCell	Monocytes-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	NLRP12 NFKBIL1 GAS7 DYSF	1.79e-04	181	69	4	d8b98c3d9bef026a0a35948219027f27718ffbee
ToppCell	3'-Pediatric_IBD-SmallIntestine-Mesenchymal-myocytic-myofibroblast_(RSPO2+)\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AEBP1 GDF6 DIXDC1 NEXN	1.79e-04	181	69	4	ab0f300d14b62cef57f1b0bdae143b8dfe8e6975
ToppCell	P28-Mesenchymal-mesenchymal_fibroblast\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	AEBP1 LRP1 GAS7 GSN	1.79e-04	181	69	4	091e7975badd1ffa463a8ec87908be20781ecfd6
ToppCell	LA-17._Lymphocyte\|LA / Chamber and Cluster_Paper	SELPLG TPSAB1 ETS1 TPSB2	1.79e-04	181	69	4	3fd9f805fa46141b0fa7023ee5d8688d338635d5
ToppCell	P15-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	AEBP1 LRP1 GAS7 GSN	1.82e-04	182	69	4	e9fcae9d03a6faf85b91882c5da699037bc61aeb
ToppCell	droplet-Heart-4Chambers-18m-Mesenchymal\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AEBP1 LRP1 GAS7 GSN	1.82e-04	182	69	4	f4b74c2756989812abe4e7055ec8918f69d56025
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MAGED1 GDF15 KHNYN EIF4G3	1.86e-04	183	69	4	91079a11685dd466bd27a0cf5afbf3734c08a05e
ToppCell	facs-Lung-EPCAM-24m-Mesenchymal-Adventitial_Fibroblast\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AEBP1 LRP1 GAS7 GSN	1.86e-04	183	69	4	63294d66e3ccf152ffe5d1237106764c14390b62
ToppCell	facs-Lung-EPCAM-24m-Mesenchymal-adventitial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AEBP1 LRP1 GAS7 GSN	1.86e-04	183	69	4	7e5c467fd1b156b928f1611a12ab4affb9f714b7
ToppCell	P07-Mesenchymal-mesenchymal_fibroblast-mesenchymal_alveolar_niche_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	AEBP1 LRP1 GAS7 GSN	1.90e-04	184	69	4	01257e5c12e38b849fd3d9496c43ded666249ba5
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ROBO4 ETS1 NOTO DYSF	1.90e-04	184	69	4	688428103e8b19f45f2f65d70a0f30c904c8411c
ToppCell	droplet-Limb_Muscle-Pre-Sort-18m-Mesenchymal\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AEBP1 LRP1 NEXN GSN	1.90e-04	184	69	4	c9d7ec17cc5b7ba1b1e721ca392746e8f4a3d41f
ToppCell	10x5'v1-week_14-16-Myeloid_neutrophil-granulo-eo/baso/mast-eosinophil\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	TPSAB1 HYAL3 SIGLEC10 TPSB2	1.90e-04	184	69	4	ce31684772e47a294155f368e50b49753f7c8e87
ToppCell	droplet-Heart-4Chambers-18m-Mesenchymal-fibroblast\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AEBP1 LRP1 GAS7 GSN	1.98e-04	186	69	4	35c88cc4eb388811fcac4323b549e5897fa8dc27
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-24m-Mesenchymal-mesenchymal_stem_cell\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AEBP1 LRP1 GAS7 GSN	1.98e-04	186	69	4	ff6ccfdf2509f96caa10281c29a95b432f6c6dcc
ToppCell	Control-Endothelial_cells-Endothelial_cells_(other)\|Control / group, cell type (main and fine annotations)	ROBO4 HYAL1 ETS1 DYSF	1.98e-04	186	69	4	c6075fe84226b370c5139066793844ad33ae2db1
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ROBO4 DYSF MAP4K2 GSN	1.98e-04	186	69	4	e9d12f2fcd346fc8d00f7178324ea5997628df8a
ToppCell	Thalamus-Endothelial\|Thalamus / BrainAtlas - Mouse McCarroll V32	EPHX1 HELZ2 ETS1 DYSF	1.98e-04	186	69	4	dcc6e4417c4123d5ca6b96fa8ca4874626aaebdb
ToppCell	droplet-Mammary_Gland-nan-21m-Mesenchymal-nan\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TPSAB1 AEBP1 LRP1 GSN	1.98e-04	186	69	4	cc94e0c5d1665d2ea2bb871ad79d8e1ec2249fb5
ToppCell	droplet-Heart-4Chambers-18m-Mesenchymal-fibroblast_of_cardiac_tissue\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AEBP1 LRP1 GAS7 GSN	1.98e-04	186	69	4	d998c5b00083cf2a7cd5341a98b7374b4de73c63
ToppCell	3'-GW_trimst-1-SmallIntestine-Endothelial-blood_vessel_EC-arterial_capillary\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ROBO4 DYSF MAP4K2 GSN	2.02e-04	187	69	4	50d5730e2cd4951d3ad0641fc81ae9f6ddabafe7
ToppCell	Monocytes-M2-like_CD16+_macrophages\|Monocytes / Immune cells in Kidney/Urine in Lupus Nephritis	EPHX1 ARHGAP6 GDF7 NEB	2.02e-04	187	69	4	59e31c51183ed4c9a3d0792c8005ea3a12b28dfa
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	AEBP1 LRP1 GAS7 GSN	2.06e-04	188	69	4	c32d023a69b6da79687ff8fa7485e7499db57046
ToppCell	T_cells-ISG-high_CD4+_T_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	GSDMD HELZ2 MASTL NEXN	2.06e-04	188	69	4	6f8946d4710f6e32c937213f99b790b098b8819c
ToppCell	Monocytes-Donor_08\|World / lung cells shred on cell class, cell subclass, sample id	NLRP12 NFKBIL1 SIGLEC10 GAS7	2.06e-04	188	69	4	756375cf9c9cccc4fb4a7f5e4756fa3fc36a7892
ToppCell	droplet-Thymus-nan-21m-Lymphocytic-double_negative_T_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPHX1 ETS1 MINPP1 GSN	2.06e-04	188	69	4	e0184d9f6687d7ecb8fc461294ff7208f49c437c
ToppCell	kidney_cells-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	AEBP1 LRP1 GAS7 GSN	2.06e-04	188	69	4	1cd5a4d744bd3777246958ea5eb94388a5cbad81
ToppCell	facs-Large_Intestine-Distal-3m-Epithelial-Lgr5+_undifferentiated_cell_(Distal)\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CERS5 AOPEP GDF15 GAS7	2.06e-04	188	69	4	5b69de5baaac45a6d4daa1dbfcb70a7b2ae744ac
ToppCell	metastatic_Lymph_Node-Myeloid_cells-Undetermined\|Myeloid_cells / Location, Cell class and cell subclass	TPSAB1 HYAL1 KIRREL2 TPSB2	2.11e-04	189	69	4	b46adb47768a7b6d801c457d7ba65508edfc36a5
ToppCell	LPS-antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGAP6 AEBP1 LRP1 NEXN	2.11e-04	189	69	4	a153b83314cf52808f685296cff8c95af3f4983d
ToppCell	facs-Lung-18m-Mesenchymal\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	AEBP1 LRP1 GAS7 GSN	2.11e-04	189	69	4	bdf8db938aa0863c4fed6fa99dcffd63c8c20c31
ToppCell	facs-Lung-18m-Mesenchymal-fibroblast\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	AEBP1 LRP1 GAS7 GSN	2.11e-04	189	69	4	40cbd679dc0548bf5207e1b033c0597886ad6fe1
ToppCell	3'-GW_trimst-1-LargeIntestine-Endothelial-blood_vessel_EC-Mature_venous_EC\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ROBO4 ETS1 DYSF MAP4K2	2.11e-04	189	69	4	b5fa3a619e3b554a1a45a551c9b6369075fe5615
ToppCell	E18.5-samps-Mesenchymal\|E18.5-samps / Age Group, Lineage, Cell class and subclass	MAGED1 LRP1 GAS7 NEXN	2.11e-04	189	69	4	0c18d3de4720759cf802eefb4d0ddde2a9246a1a
ToppCell	Monocytes-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	NLRP12 NFKBIL1 GAS7 DYSF	2.11e-04	189	69	4	22d08c7dde697f385100f72e009eeac8d19d329d
ToppCell	LV-01._Fibroblast_I\|World / Chamber and Cluster_Paper	ARHGAP6 DYNC2H1 GAS7 GSN	2.15e-04	190	69	4	12992ec80a7b4f4f17de693f0719ee061a9918fd
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Diff_MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGAP6 AEBP1 LRP1 NEXN	2.15e-04	190	69	4	841cd55861b43578d704418b9bc0af2e8b88323a
ToppCell	droplet-Mammary_Gland-nan-18m-Mesenchymal-stromal_cell\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AEBP1 LRP1 GAS7 GSN	2.15e-04	190	69	4	47077579496c5340e99f61499427a3a36b566da3
ToppCell	droplet-Mammary_Gland-nan-21m\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	AEBP1 LRP1 GAS7 GSN	2.19e-04	191	69	4	8022059e434fd411dc539819f969bd4f94861281
ToppCell	LPS-IL1RA+antiTNF-Stromal_mesenchymal-Matrix_Fibroblast-Activated_MatrixFB\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ARHGAP6 AEBP1 LRP1 GAS7	2.19e-04	191	69	4	b13229bb7f3713a392271aaf5dbae3edd1b9fe5a
ToppCell	facs-Lung-18m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l1\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	AEBP1 LRP1 GAS7 GSN	2.19e-04	191	69	4	2b73fcd592d16cae8ded5e45c8fbf2d9adc8caad
ToppCell	P07-Mesenchymal-mesenchymal_fibroblast\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MAGED1 LRP1 NEXN GSN	2.19e-04	191	69	4	a05e9a7eb137d804570dd7d8905975d735738767
Computational	Genes in the cancer module 455.	TPSAB1 FOXRED1 DYNC2H1	3.98e-04	39	40	3	MODULE_455
Computational	Immune / stress response genes.	TPSAB1 GDF15 NFKBIL1 ETS1 LRP1 NEB PLXNB1	4.65e-04	383	40	7	MODULE_33
Computational	Genes in the cancer module 486.	GPRASP1 PRPF8 MAP4K2 PLXNB1	4.98e-04	100	40	4	MODULE_486
Drug	uPA inhibitor	TPSAB1 ETS1 LRP1 TPSB2	2.31e-06	32	67	4	CID000001746
Disease	signal transducer and activator of transcription 6 measurement	NLRP12 STAT6	1.52e-05	3	67	2	EFO_0021916
Disease	tryptase beta-2 measurement	TPSAB1 TPSB2	1.81e-04	9	67	2	EFO_0008306
Disease	microphthalmia (implicated_via_orthology)	ARHGAP6 GDF6	3.30e-04	12	67	2	DOID:10629 (implicated_via_orthology)
Disease	urticaria	TPSAB1 TPSB2	9.40e-04	20	67	2	EFO_0005531
Disease	left atrial function	AOPEP GDF6	1.04e-03	21	67	2	EFO_0004294
Disease	descending aortic diameter	GDF7 LRP1 STAT6	1.07e-03	88	67	3	EFO_0021788
Disease	response to clopidogrel, cardiovascular event measurement	LIPM DYSF	1.25e-03	23	67	2	EFO_0006919, GO_1903493
Disease	response to venlafaxine	ADO DYSF	1.47e-03	25	67	2	EFO_0006328
Disease	migraine disorder, pulse pressure measurement	DYNC2H1 LRP1	1.59e-03	26	67	2	EFO_0005763, MONDO_0005277
Disease	Mental Retardation, X-Linked	ARHGEF9 BRWD3	1.98e-03	29	67	2	C1136249

Protein segments in the cluster

Peptide	Gene	Start	Entry
EDGAWPVLLDEFVEW	DCUN1D4	271	Q92564
LWGHGIAVDWAEPEV	A1CF	206	Q9NQ94
WALGLWTEEGFDIFE	AEBP1	686	Q8IUX7
WLLETPQADDFWCEG	ADO	246	Q96SZ5
DDDAIPGWEGKIVAW	DIXDC1	661	Q155Q3
SWGEGAPAWVLLDEC	GSDMD	431	P57764
GPAVDWWALGVCLFE	MASTL	756	Q96GX5
GEPNEEWFAPQWILD	BRWD3	916	Q6RI45
FGLAIGARDWTEEWL	AOPEP	486	Q8N6M6
GQILGFWEEERPFWE	CCDC70	81	Q6NSX1
FWLPENVSWADLEGP	CERS5	21	Q8N5B7
EDGAWPVLLDEFVEW	DCUN1D5	216	Q9BTE7
DDEEGWFPASFVRLW	ARHGEF9	51	O43307
FEDIGWDSWIIAPKE	GDF2	336	Q9UK05
PEITWWFEGEILQDG	NEXN	611	Q0ZGT2
DPLNEPWEEEWTLLG	MAP4K2	346	Q12851
ACLPRWLEAEWIFGG	ENTPD5	271	O75356
VSGPWSWDDIEFELL	MAGED1	701	Q9Y5V3
TWDEEGDFGDPWSRI	MAGED1	716	Q9Y5V3
LDLGFEEWDVAGLPW	MDM4	186	O15151
IPEWAHVDFIWGLDA	LIPM	381	Q5VYY2
PRDGILFWTDWDASL	LRP1	1396	Q07954
FQELGWRDWILQPEG	INHBE	256	P58166
WTGDGWEFKLSDPDE	ETS1	356	P14921
WLTREGGELPEADEW	PLXNB1	841	O43157
GEEADLVAPDWGWVD	C19orf85	186	A0A1B0GUS0
GLWAFPDWAPTEDLQ	NOTO	136	A8MTQ0
EDLGWADWVLSPREV	GDF15	221	Q99988
ILGWGPPWDSAEEEE	NFKBIL1	141	Q9UBC1
EQDSPRLGDAGWLDW	ARHGAP6	936	O43182
GAYLEDQLAWDWGPD	PRSS36	556	Q5K4E3
DQLAWDWGPDGEETE	PRSS36	561	Q5K4E3
WIICDGDIDPEWIES	DYNC2H1	2051	Q8NCM8
RDKEETLPLEDGWWG	EPHX1	21	P07099
GMEDEGWFDPWCLLQ	FOXRED1	211	Q96CU9
DFEAFGWDWIIAPKR	GDF11	321	O95390
EAFLHLWPDGSLGDW	HYAL3	376	O43820
PWWITEDDFKDDGLL	CEP162	46	Q5TB80
WREAGLSWKEFLPEG	EIF4G1	1396	Q04637
APDAVVWSWDEGFLE	KIRREL2	426	Q6UWL6
GWKELPGEEAWEREV	KHNYN	271	O15037
LGWDDDYWSVDPLDR	GSN	761	P06396
DFSGLAVIDWEAWRP	HYAL1	121	Q12794
DAEADFWPWDGELNA	HELZ2	1056	Q9BYK8
FWPWDGELNADDAIL	HELZ2	1061	Q9BYK8
WNEGFEWDLKGIPLD	DYSF	46	O75923
WREADLSWKDFLPEG	EIF4G3	1376	O43432
PEAEEGDIIGSWFWA	GPRASP1	771	Q5JY77
SWFWAGEEDRLEPAA	GPRASP1	781	Q5JY77
LGWDDWIIAPLEYEA	GDF6	366	Q6KF10
PDLWWELGLELPDGA	RXFP3	46	Q9NSD7
WDTWADEAEKALGPL	SELPLG	21	Q14242
WVTGWGDVDNDERLP	TPSAB1	156	Q15661
WVTGWGDVDNDERLP	TPSB2	156	P20231
LLQVPDGGWWEGEKE	GAS7	31	O60861
ALRFLWGSEQGWEDP	SLC2A8	221	Q9NY64
VDFKELGWDDWIIAP	GDF7	356	Q7Z4P5
LGWDDWIIAPLDYEA	GDF7	361	Q7Z4P5
NSWIEDTEFLWGPAL	SI	726	P14410
EGVWARVPSLDWEGL	TRIOBP	1571	Q9H2D6
PWAEELLAGWQSAEL	ROBO4	296	Q8WZ75
DLEEEEERWEWSPAG	SERTAD3	11	Q9UJW9
PTWEGLFWEKASGFE	PRPF8	1496	Q6P2Q9
FADCVGDELPWGWEA	WWC2	51	Q6AWC2
DLGAALADWPLWYAD	MINPP1	126	Q9UNW1
GDWLESQPWEFLVGS	STAT6	31	P42226
LDGVWGRVLDDAWDL	SCART1	451	Q4G0T1
WSDPDKDVLGWGEND	PPP1CC	206	P36873
GEDDPWLDDTAAWIE	SART1	191	O43290
RPGWVEVKDEGEWDF	TTLL9	61	Q3SXZ7
PIGWFELEEEWDEAD	ZZEF1	651	O43149
APSLRWWLGEELLEG	SIGLEC10	471	Q96LC7
LDLSFNDLGDWGLWL	NLRP12	946	P59046
ADLEWLRGIGWIPLD	NEB	4356	P20929