Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontransmembrane receptor protein tyrosine kinase activity

RYK FGFR2

7.95e-0465132GO:0004714
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

GPR45 RYK FGFR2 PTPRE MC3R

1.15e-031353135GO:0004888
GeneOntologyMolecularFunctiontransmembrane receptor protein kinase activity

RYK FGFR2

1.35e-0385132GO:0019199
GeneOntologyMolecularFunctionprotein tyrosine kinase activity

RYK FGFR2

3.88e-03145132GO:0004713
GeneOntologyBiologicalProcessbranch elongation of an epithelium

TMTC3 FGFR2

8.41e-0522132GO:0060602
GeneOntologyBiologicalProcessaxis elongation

TMTC3 FGFR2

2.55e-0438132GO:0003401
GeneOntologyBiologicalProcessepithelial tube branching involved in lung morphogenesis

TMTC3 FGFR2

2.97e-0441132GO:0060441
GeneOntologyBiologicalProcesssodium ion homeostasis

SLC12A1 MC3R

4.59e-0451132GO:0055078
GeneOntologyBiologicalProcessdevelopmental growth involved in morphogenesis

TMTC3 RYK FGFR2

7.74e-04299133GO:0060560
GeneOntologyBiologicalProcesscell surface receptor protein tyrosine kinase signaling pathway

LRIG2 RYK FGFR2 PTPRE

9.39e-04747134GO:0007169
GeneOntologyBiologicalProcesslung alveolus development

TMTC3 FGFR2

9.92e-0475132GO:0048286
GeneOntologyBiologicalProcesslung morphogenesis

TMTC3 FGFR2

1.04e-0377132GO:0060425
GeneOntologyBiologicalProcessmidbrain development

RYK FGFR2

1.65e-0397132GO:0030901
MousePhenoabnormal midface morphology

RYK FGFR2

1.72e-0428102MP:0030095
MousePhenoabnormal branching involved in lung morphogenesis

TMTC3 FGFR2

2.55e-0434102MP:0011024
MousePhenoimpaired lung alveolus development

TMTC3 FGFR2

4.29e-0444102MP:0006027
MousePhenodecreased osteoblast cell number

FGFR2 JAM2

4.49e-0445102MP:0004989
MousePhenoabnormal hindlimb morphology

RYK FGFR2 PTPRE MC3R

4.91e-04576104MP:0000556
MousePhenoabnormal lung alveolus development

TMTC3 FGFR2

5.54e-0450102MP:0010995
MousePhenoabnormal long bone morphology

RYK FGFR2 PTPRE MC3R

9.01e-04676104MP:0003723
MousePhenoabnormal nasal bone morphology

RYK FGFR2

1.05e-0369102MP:0000102
MousePhenoabnormal osteoblast cell number

FGFR2 JAM2

1.31e-0377102MP:0004987
MousePhenoabnormal bone structure

FGFR2 SLC12A1 JAM2 PTPRE MC3R

1.53e-031379105MP:0003795
MousePhenoshort facial bone

RYK FGFR2

2.37e-03104102MP:0030384
MousePhenopostnatal growth retardation

TMTC3 RYK FGFR2 SLC12A1

2.42e-03881104MP:0001732
MousePhenoabnormal appendicular skeleton morphology

RYK FGFR2 PTPRE MC3R

2.58e-03896104MP:0009250
MousePhenoabnormal postnatal growth

TMTC3 RYK FGFR2 SLC12A1

2.69e-03907104MP:0001731
MousePhenoabnormal tongue morphology

RYK FGFR2

3.04e-03118102MP:0000762
MousePhenocleft secondary palate

RYK FGFR2

3.51e-03127102MP:0009890
MousePhenoshort snout

RYK FGFR2

4.02e-03136102MP:0000445
MousePhenoabnormal osteoblast morphology

FGFR2 JAM2

4.08e-03137102MP:0004986
MousePhenoabnormal limb morphology

RYK FGFR2 PTPRE MC3R

4.26e-031028104MP:0002109
DomainI-set

LRIG2 IGDCC3 FGFR2 JAM2

6.91e-06190134PF07679
DomainIg_I-set

LRIG2 IGDCC3 FGFR2 JAM2

6.91e-06190134IPR013098
DomainIg_sub2

LRIG2 IGDCC3 FGFR2 JAM2

1.60e-05235134IPR003598
DomainIGc2

LRIG2 IGDCC3 FGFR2 JAM2

1.60e-05235134SM00408
DomainIg_sub

LRIG2 IGDCC3 FGFR2 JAM2

1.55e-04421134IPR003599
DomainIG

LRIG2 IGDCC3 FGFR2 JAM2

1.55e-04421134SM00409
DomainImmunoglobulin

LRIG2 IGDCC3 JAM2

2.75e-04190133IPR013151
Domainig

LRIG2 IGDCC3 JAM2

2.75e-04190133PF00047
DomainIG_LIKE

LRIG2 IGDCC3 FGFR2 JAM2

2.79e-04491134PS50835
DomainIg-like_dom

LRIG2 IGDCC3 FGFR2 JAM2

3.06e-04503134IPR007110
Domain-

LRIG2 IGDCC3 FGFR2 JAM2

8.71e-046631342.60.40.10
DomainIg-like_fold

LRIG2 IGDCC3 FGFR2 JAM2

1.10e-03706134IPR013783
DomainTyrKc

RYK FGFR2

1.66e-0388132SM00219
DomainTyr_kinase_cat_dom

RYK FGFR2

1.66e-0388132IPR020635
DomainPROTEIN_KINASE_TYR

RYK FGFR2

2.01e-0397132PS00109
DomainTyr_kinase_AS

RYK FGFR2

2.01e-0397132IPR008266
DomainPkinase_Tyr

RYK FGFR2

3.51e-03129132PF07714
DomainSer-Thr/Tyr_kinase_cat_dom

RYK FGFR2

4.01e-03138132IPR001245
Pubmed

Testing reported associations of genetic risk factors for oral clefts in a large Irish study population.

RYK FGFR2

8.49e-061213219937600
Pubmed

Expression of the immunoglobulin superfamily cell adhesion molecules in the developing spinal cord and dorsal root ganglion.

LRIG2 IGDCC3 JAM2

2.74e-0516213325826454
Pubmed

Murine txk: a protein tyrosine kinase gene regulated by T cell activation.

RYK FGFR2

6.36e-05321327542761
Pubmed

A candidate gene study of obstructive sleep apnea in European Americans and African Americans.

FGFR2 MC3R

1.69e-045213220538960
Pubmed

Microarray analysis of Foxa2 mutant mouse embryos reveals novel gene expression and inductive roles for the gastrula organizer and its derivatives.

IGDCC3 RYK FGFR2

1.81e-0430613318973680
Cytoband10q26

FGFR2 PTPRE

1.87e-052313210q26
CytobandEnsembl 112 genes in cytogenetic band chr10q26

FGFR2 PTPRE

1.53e-03207132chr10q26
GeneFamilyBlood group antigens|CD molecules|I-set domain containing|Immunoglobulin like domain containing

LRIG2 IGDCC3 FGFR2 JAM2

2.84e-06161124593
GeneFamilyReceptor Tyrosine Kinases|CD molecules

RYK FGFR2

3.11e-0440122321
GeneFamilyADAM metallopeptidase domain containing|CD molecules

FGFR2 JAM2

2.71e-02394122471
ComputationalGenes in the cancer module 85.

RYK FGFR2

4.57e-045172MODULE_85
ComputationalGenes in the cancer module 199.

RYK FGFR2

5.70e-045772MODULE_199
ComputationalMembranal receptors.

FGFR2 JAM2 PTPRE

3.35e-0351773MODULE_64
Drugbenzmetanide

TMTC3 SLC12A1

1.05e-0427132CID000168795
DrugSTOCK1N-35215; Down 200; 10uM; MCF7; HT_HG-U133A

MPPE1 RYK FGFR2

1.61e-041931336422_DN
Drugvanadyl sulfate

FGFR2 JAM2 PTPRE

1.61e-04193133ctd:C034028
DrugDiphenidol hydrochloride [3254-89-5]; Down 200; 11.6uM; MCF7; HT_HG-U133A

MPPE1 FGFR2 PTPRE

1.61e-041931337447_DN
Drugalpha-estradiol; Down 200; 0.01uM; MCF7; HT_HG-U133A

LRIG2 MPPE1 FGFR2

1.69e-041961336970_DN
DrugNorgestrel-(-)-D [797-63-7]; Up 200; 12.8uM; HL60; HT_HG-U133A

GPR45 FGFR2 MC3R

1.69e-041961332547_UP
DrugPromethazine hydrochloride [58-33-3]; Down 200; 12.4uM; MCF7; HT_HG-U133A

MPPE1 RYK FGFR2

1.69e-041961335317_DN
DrugClindamycin hydrochloride [21462-39-5]; Up 200; 8.6uM; PC3; HT_HG-U133A

LRIG2 MPPE1 FGFR2

1.74e-041981335815_UP
Drug2-propylpentanoic acid; Up 200; 1000uM; MCF7; HT_HG-U133A

LRIG2 MPPE1 FGFR2

1.76e-041991336929_UP
DrugArtemisinin [63968-64-9]; Down 200; 14.2uM; PC3; HT_HG-U133A

LRIG2 MPPE1 RYK

1.76e-041991337247_DN
DrugAminocaproic acid [60-32-2]; Down 200; 30.4uM; PC3; HT_HG-U133A

LRIG2 MPPE1 RYK

1.76e-041991337258_DN
DiseaseCleft palate, isolated

RYK FGFR2

1.53e-0442132C1837218
DiseaseCleft Palate

RYK FGFR2

5.69e-0481132C0008925

Protein segments in the cluster

PeptideGeneStartEntry
YCIGVFLIACMVVTV

FGFR2

381

P21802
YGNIRVCVEDCVVLV

PTPRE

256

P23469
IVIGIHIGVTCIIFC

IGDCC3

641

Q8IVU1
EYMVQGECVAVVVVC

LCN9

76

Q8WX39
VVLIIYCGVVGFLVV

MPPE1

356

Q53F39
VVALVISVCGLGVCY

JAM2

246

P57087
VVGFLGNTVVCIIVY

GPR45

46

Q9Y5Y3
VVVTTVGCLCVVYVL

PKD1L2

1346

Q7Z442
CCGVCGVVFIVYSES

MC3R

171

P41968
TRVFYISVGVCCAVI

RYK

226

P34925
YLGVAICVGACVVRD

SLC12A1

426

Q13621
GITVVGICCVYEVFI

TMTC3

191

Q6ZXV5
VGIVIIVVVCCVVGT

LRIG2

806

O94898