Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	aspartic-type endopeptidase activity	ERVK-6 ERVK-18 BACE1 ERVK-7 ERVK-25 NCSTN ERVK-10	1.54e-10	37	83	7	GO:0004190
GeneOntologyMolecularFunction	aspartic-type peptidase activity	ERVK-6 ERVK-18 BACE1 ERVK-7 ERVK-25 NCSTN ERVK-10	1.88e-10	38	83	7	GO:0070001
GeneOntologyMolecularFunction	RNA-DNA hybrid ribonuclease activity	ERVK-6 ERVK-7 ERVK-10 ERVK-11	8.96e-08	11	83	4	GO:0004523
GeneOntologyMolecularFunction	RNA-directed DNA polymerase activity	ERVK-6 ERVK-7 ERVK-10 ERVK-11	2.69e-07	14	83	4	GO:0003964
GeneOntologyMolecularFunction	RNA stem-loop binding	ERVK-6 ERVK-7 ERVK-10 ERVK-11	1.57e-06	21	83	4	GO:0035613
GeneOntologyMolecularFunction	RNA endonuclease activity, producing 5'-phosphomonoesters	ERVK-6 ERVK-7 ERVK-10 ERVK-11	1.65e-05	37	83	4	GO:0016891
GeneOntologyMolecularFunction	dolichyl pyrophosphate Glc2Man9GlcNAc2 alpha-1,2-glucosyltransferase activity	ALG10 ALG10B	1.71e-05	2	83	2	GO:0106073
GeneOntologyMolecularFunction	DNA polymerase activity	ERVK-6 ERVK-7 ERVK-10 ERVK-11	1.84e-05	38	83	4	GO:0034061
GeneOntologyMolecularFunction	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	ERVK-6 ERVK-7 ERVK-10 ERVK-11	3.96e-05	46	83	4	GO:0016893
GeneOntologyMolecularFunction	amino acid:monoatomic cation symporter activity	SLC6A7 SLC6A13 SLC36A3	2.34e-04	29	83	3	GO:0005416
GeneOntologyMolecularFunction	RNA endonuclease activity	ERVK-6 ERVK-7 ERVK-10 ERVK-11	3.29e-04	79	83	4	GO:0004521
GeneOntologyMolecularFunction	L-proline transmembrane transporter activity	SLC6A7 SLC36A3	3.54e-04	7	83	2	GO:0015193
GeneOntologyMolecularFunction	peptidase activity	ERVK-6 TPP2 VASH2 ERVK-18 BACE1 ERVK-7 ERVK-25 NCSTN ERVK-10 CPVL	3.75e-04	654	83	10	GO:0008233
GeneOntologyMolecularFunction	endopeptidase activity	ERVK-6 TPP2 ERVK-18 BACE1 ERVK-7 ERVK-25 NCSTN ERVK-10	4.17e-04	430	83	8	GO:0004175
GeneOntologyMolecularFunction	amino acid transmembrane transporter activity	SLC6A7 SLC6A13 SLC36A3 GRIK3	9.64e-04	105	83	4	GO:0015171
GeneOntologyMolecularFunction	serine-type exopeptidase activity	TPP2 CPVL	1.10e-03	12	83	2	GO:0070008
GeneOntologyMolecularFunction	transferase activity, transferring phosphorus-containing groups	ERVK-6 MET PGS1 MAST4 TIE1 PAK5 PAK4 ERVK-7 ERVK-10 ERVK-11 MAP3K4	1.69e-03	938	83	11	GO:0016772
GeneOntologyMolecularFunction	carboxylic acid transmembrane transporter activity	SLC6A7 SLC22A9 SLC6A13 SLC36A3 GRIK3	1.72e-03	207	83	5	GO:0046943
GeneOntologyMolecularFunction	G protein-coupled photoreceptor activity	ELOVL4 RRH	1.73e-03	15	83	2	GO:0008020
GeneOntologyMolecularFunction	organic acid transmembrane transporter activity	SLC6A7 SLC22A9 SLC6A13 SLC36A3 GRIK3	1.76e-03	208	83	5	GO:0005342
GeneOntologyMolecularFunction	photoreceptor activity	ELOVL4 RRH	2.23e-03	17	83	2	GO:0009881
GeneOntologyMolecularFunction	RNA nuclease activity	ERVK-6 ERVK-7 ERVK-10 ERVK-11	2.50e-03	136	83	4	GO:0004540
GeneOntologyMolecularFunction	endonuclease activity	ERVK-6 ERVK-7 ERVK-10 ERVK-11	2.50e-03	136	83	4	GO:0004519
GeneOntologyMolecularFunction	nuclease activity	DXO ERVK-6 ERVK-7 ERVK-10 ERVK-11	2.77e-03	231	83	5	GO:0004518
GeneOntologyMolecularFunction	proteasome binding	PSME4 WFS1	3.09e-03	20	83	2	GO:0070628
GeneOntologyMolecularFunction	nucleotidyltransferase activity	ERVK-6 ERVK-7 ERVK-10 ERVK-11	3.72e-03	152	83	4	GO:0016779
GeneOntologyMolecularFunction	glucosyltransferase activity	ALG10 ALG10B	3.74e-03	22	83	2	GO:0046527
GeneOntologyMolecularFunction	amino acid:sodium symporter activity	SLC6A7 SLC6A13	4.08e-03	23	83	2	GO:0005283
GeneOntologyBiologicalProcess	DNA integration	ERVK-6 ERVK-7 ERVK-10 ERVK-11	1.54e-07	13	81	4	GO:0015074
GeneOntologyBiologicalProcess	RNA-templated DNA biosynthetic process	ERVK-6 ERVK-7 ERVK-10 ERVK-11 MAP3K4	1.88e-05	83	81	5	GO:0006278
GeneOntologyBiologicalProcess	DNA synthesis involved in DNA repair	ERVK-6 ERVK-7 ERVK-10 ERVK-11	3.77e-05	48	81	4	GO:0000731
GeneOntologyBiologicalProcess	branching involved in lymph vessel morphogenesis	TIE1 NFATC1	4.56e-05	3	81	2	GO:0060854
GeneOntologyBiologicalProcess	positive regulation of amyloid precursor protein biosynthetic process	ABCA2 NCSTN	9.09e-05	4	81	2	GO:0042986
GeneOntologyBiologicalProcess	protein retention in Golgi apparatus	VPS13D VPS13C	1.51e-04	5	81	2	GO:0045053
Domain	Alg10	ALG10 ALG10B	1.72e-05	2	78	2	IPR016900
Domain	DIE2_ALG10	ALG10 ALG10B	1.72e-05	2	78	2	PF04922
Domain	VPS13	VPS13D VPS13C	5.15e-05	3	78	2	IPR026847
Domain	VPS13_mid_rpt	VPS13D VPS13C	5.15e-05	3	78	2	PF16910
Domain	VPS13	VPS13D VPS13C	5.15e-05	3	78	2	PF16908
Domain	VPS13_N2	VPS13D VPS13C	5.15e-05	3	78	2	IPR031646
Domain	VPS13_mid_rpt	VPS13D VPS13C	5.15e-05	3	78	2	IPR031642
Domain	VPS13_C	VPS13D VPS13C	1.03e-04	4	78	2	PF16909
Domain	SHR-BD	VPS13D VPS13C	1.03e-04	4	78	2	IPR009543
Domain	VPS13_C	VPS13D VPS13C	1.03e-04	4	78	2	IPR031645
Domain	SHR-BD	VPS13D VPS13C	1.03e-04	4	78	2	PF06650
Domain	PAK_BD	PAK5 PAK4	2.55e-04	6	78	2	IPR033923
Domain	WASP_C	PAK5 PAK4	3.57e-04	7	78	2	IPR011026
Domain	VPS13_N	VPS13D VPS13C	4.74e-04	8	78	2	IPR026854
Domain	Chorein_N	VPS13D VPS13C	4.74e-04	8	78	2	PF12624
Domain	fn3	EPOR PTPRG TIE1 L1CAM MYOM3	5.85e-04	162	78	5	PF00041
Domain	FN3	EPOR PTPRG TIE1 L1CAM MYOM3	1.06e-03	185	78	5	SM00060
Domain	-	PAK5 PAK4	1.11e-03	12	78	2	3.90.810.10
Domain	ABC_A	ABCA2 ABCA4	1.11e-03	12	78	2	IPR026082
Domain	ASP_PROTEASE	ERVK-6 BACE1	1.11e-03	12	78	2	PS00141
Domain	Aspartic_peptidase_AS	ERVK-6 BACE1	1.30e-03	13	78	2	IPR001969
Domain	FN3	EPOR PTPRG TIE1 L1CAM MYOM3	1.47e-03	199	78	5	PS50853
Domain	FN3_dom	EPOR PTPRG TIE1 L1CAM MYOM3	1.82e-03	209	78	5	IPR003961
Domain	PBD	PAK5 PAK4	1.99e-03	16	78	2	SM00285
Domain	PBD	PAK5 PAK4	2.25e-03	17	78	2	PF00786
Domain	NA_NEUROTRAN_SYMP_2	SLC6A7 SLC6A13	2.52e-03	18	78	2	PS00754
Domain	SNF	SLC6A7 SLC6A13	2.81e-03	19	78	2	PF00209
Domain	NA_NEUROTRAN_SYMP_1	SLC6A7 SLC6A13	2.81e-03	19	78	2	PS00610
Domain	NA_NEUROTRAN_SYMP_3	SLC6A7 SLC6A13	2.81e-03	19	78	2	PS50267
Domain	Na/ntran_symport	SLC6A7 SLC6A13	2.81e-03	19	78	2	IPR000175
Domain	CRIB	PAK5 PAK4	3.12e-03	20	78	2	PS50108
Domain	CRIB_dom	PAK5 PAK4	3.43e-03	21	78	2	IPR000095
Domain	zf-CCHC	ERVK-6 DDX41	4.12e-03	23	78	2	PF00098
Domain	IPT	MET NFATC1	5.65e-03	27	78	2	SM00429
Domain	TIG	MET NFATC1	7.40e-03	31	78	2	PF01833
Domain	IPT	MET NFATC1	7.87e-03	32	78	2	IPR002909
Pathway	WP_DYRK1A_INVOLVEMENT_REGARDING_CELL_PROLIFERATION_IN_BRAIN_DEVELOPMENT	NFATC1 RPTOR BACE1 NCSTN DCAF7	4.10e-06	62	55	5	M45532
Pubmed	Many human endogenous retrovirus K (HERV-K) proviruses are unique to humans.	ERVK-6 ERVK-7 ERVK-10	5.83e-08	4	86	3	10469592
Pubmed	Expression patterns of transcribed human endogenous retrovirus HERV-K(HML-2) loci in human tissues and the need for a HERV Transcriptome Project.	ERVK-18 ERVK-25 ERVK-10 ERVK-11	1.04e-07	18	86	4	18664271
Pubmed	A revised nomenclature for transcribed human endogenous retroviral loci.	ERVK-6 ERVK-18 ERVK-7 ERVK-25 ERVK-10 ERVK-11	1.31e-07	94	86	6	21542922
Pubmed	Quantitation of HERV-K env gene expression and splicing in human breast cancer.	ERVK-6 ERVK-18 ERVK-7	1.45e-07	5	86	3	12629516
Pubmed	Large-scale structural analysis of the classical human protein tyrosine phosphatome.	MET EPOR PTPRG TIE1	5.73e-06	47	86	4	19167335
Pubmed	Herpes simplex virus infection causes cellular beta-amyloid accumulation and secretase upregulation.	BACE1 NCSTN	6.04e-06	2	86	2	17980964
Pubmed	BACE1 interacts with nicastrin.	BACE1 NCSTN	6.04e-06	2	86	2	12054507
Pubmed	Interferon-alpha-induced endogenous superantigen. a model linking environment and autoimmunity.	ERVK-6 ERVK-18	6.04e-06	2	86	2	11672541
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	VPS13D MAST4 RPTOR PAK5 PAK4 DOCK7 GAN RTKN DDX41 UTRN DCAF7	9.07e-06	861	86	11	36931259
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	PAK4 DOCK7 SH3GLB2 RTKN CPVL UTRN NUP160 DCAF7	1.52e-05	446	86	8	24255178
Pubmed	A point mutation in the gene for asparagine-linked glycosylation 10B (Alg10b) causes nonsyndromic hearing impairment in mice (Mus musculus).	ALG10 ALG10B	1.81e-05	3	86	2	24303013
Pubmed	c-Abl links APP-BACE1 interaction promoting APP amyloidogenic processing in Niemann-Pick type C disease.	NPC1 BACE1	1.81e-05	3	86	2	27565738
Pubmed	Genome-wide screening, cloning, chromosomal assignment, and expression of full-length human endogenous retrovirus type K.	ERVK-6 ERVK-18	1.81e-05	3	86	2	10516026
Pubmed	Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization.	ABCA2 NCSTN	1.81e-05	3	86	2	22086926
Pubmed	Identification of an active reverse transcriptase enzyme encoded by a human endogenous HERV-K retrovirus.	ERVK-6 ERVK-11	1.81e-05	3	86	2	9971820
Pubmed	Altered levels and distribution of amyloid precursor protein and its processing enzymes in Niemann-Pick type C1-deficient mouse brains.	NPC1 BACE1	1.81e-05	3	86	2	20607864
Pubmed	p120-catenin is a binding partner and substrate for Group B Pak kinases.	PAK5 PAK4	1.81e-05	3	86	2	20564219
Pubmed	The neural cell adhesion molecules L1 and CHL1 are cleaved by BACE1 protease in vivo.	L1CAM BACE1	1.81e-05	3	86	2	22692213
Pubmed	Stimulation of calcineurin signaling attenuates the dystrophic pathology in mdx mice.	NFATC1 UTRN	1.81e-05	3	86	2	14681302
Pubmed	Calcium and calcineurin-NFAT signaling regulate granulocyte-monocyte progenitor cell cycle via Flt3-L.	FLT3LG NFATC1	1.81e-05	3	86	2	25100642
Pubmed	Evaluation of the ELOVL4, PRPH2 and ABCA4 genes in patients with Stargardt macular degeneration.	ELOVL4 ABCA4	1.81e-05	3	86	2	22948568
Pubmed	The ATP-binding cassette transporter-2 (ABCA2) increases endogenous amyloid precursor protein expression and Aβ fragment generation.	ABCA2 BACE1	1.81e-05	3	86	2	20704561
Pubmed	Analysis of the human VPS13 gene family.	VPS13D VPS13C	3.61e-05	4	86	2	15498460
Pubmed	Expression of utrophin A mRNA correlates with the oxidative capacity of skeletal muscle fiber types and is regulated by calcineurin/NFAT signaling.	NFATC1 UTRN	3.61e-05	4	86	2	12808150
Pubmed	The IKr drug response is modulated by KCR1 in transfected cardiac and noncardiac cell lines.	ALG10 ALG10B	3.61e-05	4	86	2	14525949
Pubmed	Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice.	FLT3LG NCSTN	3.61e-05	4	86	2	22547652
Pubmed	A strategy focused on MAPT, APP, NCSTN and BACE1 to build blood classifiers for Alzheimer's disease.	BACE1 NCSTN	3.61e-05	4	86	2	25863267
Pubmed	BACE1-cleavage of Sez6 and Sez6L is elevated in Niemann-Pick type C disease mouse brains.	NPC1 BACE1	3.61e-05	4	86	2	29979789
Pubmed	PAK5, a new brain-specific kinase, promotes neurite outgrowth in N1E-115 cells.	PAK5 PAK4	3.61e-05	4	86	2	11756552
Pubmed	Effect of cancer-associated mutations in the PlexinB1 gene.	MET RTKN	3.61e-05	4	86	2	22404908
Pubmed	Human endogenous retrovirus K10: expression of Gag protein and detection of antibodies in patients with seminomas.	ERVK-6 ERVK-10	3.61e-05	4	86	2	7983737
Pubmed	The emerging importance of group II PAKs.	PAK5 PAK4	3.61e-05	4	86	2	20070256
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	ABCA2 MAST4 PSME4 VPS13C RPTOR PAK4 SH3GLB2 NCSTN	5.10e-05	529	86	8	14621295
Pubmed	Transcriptionally active HERV-K genes: identification, isolation, and chromosomal mapping.	ERVK-6 ERVK-7	6.01e-05	5	86	2	11401426
Pubmed	STAT3, STAT4, NFATc1, and CTCF regulate PD-1 through multiple novel regulatory regions in murine T cells.	NFATC1 STAT4	6.01e-05	5	86	2	24711622
Pubmed	Characterization of presenilin complexes from mouse and human brain using Blue Native gel electrophoresis reveals high expression in embryonic brain and minimal change in complex mobility with pathogenic presenilin mutations.	BACE1 NCSTN	9.01e-05	6	86	2	14717705
Pubmed	Targeted disruption of the gene for the PAK5 kinase in mice.	PAK5 PAK4	9.01e-05	6	86	2	14517284
Pubmed	GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells.	STAT4 MAP3K4	9.01e-05	6	86	2	15044949
Pubmed	mTORC1 controls the adaptive transition of quiescent stem cells from G0 to G(Alert).	MET RPTOR	1.26e-04	7	86	2	24870234
Pubmed	An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease.	BACE1 NCSTN	1.68e-04	8	86	2	25592972
Pubmed	Spatial segregation of gamma-secretase and substrates in distinct membrane domains.	BACE1 NCSTN	1.68e-04	8	86	2	15886206
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	PDE4B RPTOR PAK4 DOCK7 PLEKHA6 RASSF9 CINP RTKN RWDD4 DCAF7	2.44e-04	1038	86	10	26673895
Pubmed	The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met.	MET SH3GLB2	3.28e-04	11	86	2	11894096
Pubmed	Transcriptomic analysis of murine embryos lacking endogenous retinoic acid signaling.	BHLHE40 STAT4	3.28e-04	11	86	2	23638021
Pubmed	Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.	RPTOR RTKN	3.93e-04	12	86	2	15467718
Pubmed	Mitochondrial complex II regulates a distinct oxygen sensing mechanism in monocytes.	MET SDHC	3.93e-04	12	86	2	28204537
Pubmed	Alternative splice variants encoding unstable protein domains exist in the human brain.	ABCA2 BACE1	4.63e-04	13	86	2	15491607
Pubmed	Linkage and association of successful aging to the 6q25 region in large Amish kindreds.	ELOVL4 MAP3K4	4.63e-04	13	86	2	22773346
Pubmed	EDEM1 Drives Misfolded Protein Degradation via ERAD and Exploits ER-Phagy as Back-Up Mechanism When ERAD Is Impaired.	NPC1 WFS1 RPTOR BACE1	5.36e-04	150	86	4	32423001
Pubmed	Loss of flow responsive Tie1 results in Impaired Aortic valve remodeling.	TIE1 NFATC1	5.39e-04	14	86	2	31319059
Pubmed	Tie1 is required for lymphatic valve and collecting vessel development.	TIE1 NFATC1	5.39e-04	14	86	2	25576926
Pubmed	Sequence identification of 2,375 human brain genes.	PGS1 ABCA2	6.21e-04	15	86	2	1538749
Pubmed	Murine Creld1 controls cardiac development through activation of calcineurin/NFATc1 signaling.	EPOR NFATC1	7.09e-04	16	86	2	24697899
Pubmed	Alteration of Neuronal Excitability and Short-Term Synaptic Plasticity in the Prefrontal Cortex of a Mouse Model of Mental Illness.	PDE4B L1CAM	7.09e-04	16	86	2	28283561
Pubmed	TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.	NPC1 MET ABCA2 NCSTN	7.49e-04	164	86	4	32409323
Pubmed	Assignment of 22 loci in the rat by somatic hybrid and linkage analysis.	MET EPOR	9.01e-04	18	86	2	8268657
Pubmed	Role of Ostm1 Cytosolic Complex with Kinesin 5B in Intracellular Dispersion and Trafficking.	DOCK7 NUP160	9.01e-04	18	86	2	26598607
Pubmed	The chromosomal location of the mouse mammary tumor gene Int6 and related pseudogenes in the mouse genome.	MET MAP3K4	1.01e-03	19	86	2	7558022
Pubmed	The repertoire of solute carriers of family 6: identification of new human and rodent genes.	SLC6A7 SLC6A13	1.23e-03	21	86	2	16125675
Pubmed	Neither replication nor simulation supports a role for the axon guidance pathway in the genetics of Parkinson's disease.	PAK5 PAK4	1.35e-03	22	86	2	18628988
Pubmed	Klf2 is an essential regulator of vascular hemodynamic forces in vivo.	EPOR TIE1	1.35e-03	22	86	2	17141159
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	NPC1 TNPO1 PDE4B PSME4 FMN1 PAK4 NCSTN UTRN DSE	1.44e-03	1084	86	9	11544199
Pubmed	Functional genetic analysis of mouse chromosome 11.	ALG10 ALG10B	1.48e-03	23	86	2	12955145
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	TNPO1 PTPRG RPTOR PAK4 DOCK7 GAN RTKN DDX41 NUP160 DCAF7	1.56e-03	1321	86	10	27173435
Pubmed	Hereditary Ataxia Overview	ELOVL4 VPS13D WFS1	1.56e-03	92	86	3	20301317
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	VPS13D MAST4 DOCK7 UTRN	1.83e-03	209	86	4	36779422
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	MET TCL1A PAK5 PAK4 DDX41 UTRN MAP3K4 DCAF7	1.87e-03	910	86	8	36736316
Pubmed	An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets.	BHLHE40 STAT4	1.89e-03	26	86	2	33238123
Pubmed	Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.	RPTOR SH3GLB2 UTRN DCAF7	2.03e-03	215	86	4	35973513
Pubmed	Interspecific backcrosses provide an important new tool for centromere mapping of mouse chromosomes.	MET EPOR	2.04e-03	27	86	2	8188294
Pubmed	5-HT(6) receptor recruitment of mTOR as a mechanism for perturbed cognition in schizophrenia.	TNPO1 RPTOR	2.04e-03	27	86	2	23027611
Pubmed	Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.	PAK4 GAN DCAF7	2.10e-03	102	86	3	15778465
Pubmed	Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette.	TNPO1 VPS13D PTPRG L1CAM SDHC MAP3K4	2.16e-03	536	86	6	15840001
Pubmed	Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis.	MET TIE1	2.19e-03	28	86	2	18593464
Pubmed	Evidence that the transcriptional repressor ICER is regulated via the N-end rule for ubiquitination.	TNPO1 DDX41	2.19e-03	28	86	2	35227662
Pubmed	Exchangeable gene trap using the Cre/mutated lox system.	TNPO1 VPS13D PTPRG L1CAM SDHC MAP3K4	2.20e-03	538	86	6	10512203
Interaction	CBY1 interactions	RPTOR PAK4 DOCK7 GAN RTKN DDX41 DCAF7	7.96e-06	182	80	7	int:CBY1
GeneFamily	Alpha-1,2-glucosyltransferases	ALG10 ALG10B	8.43e-06	2	53	2	448
GeneFamily	Fibronectin type III domain containing	EPOR PTPRG TIE1 L1CAM MYOM3	1.04e-04	160	53	5	555
GeneFamily	ATP binding cassette subfamily A	ABCA2 ABCA4	7.50e-04	14	53	2	805
ToppCell	Fetal_29-31_weeks-Endothelial-endothelial_cell_of_lymph_vessel-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PDE4B ABCA4 TIE1 NFATC1 WFS1 TDRD10 RASSF9	4.37e-08	185	80	7	f9f48251bc33eb6bf2cff580d1a3207d21450aa0
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	TPP2 TIE1 FMN1 MYOM3 STAT4	1.07e-05	161	80	5	5fba13f0aa5002f7eefe219e2c6a07e163f1a50d
ToppCell	facs-Marrow-T-cells-3m-Myeloid-promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1G MET VPS13C L1CAM DSE	1.39e-05	170	80	5	a78d9789c3e7c84a36e1bd380192d7aba4a4d443
ToppCell	facs-Marrow-T-cells-3m-Myeloid-monocyte_+_promonocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1G MET VPS13C L1CAM DSE	1.39e-05	170	80	5	ff68600b945b3a5437b14e5411b3db800d0ccbe5
ToppCell	COVID-19-Heart-EC_2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MET MAST4 PTPRG TIE1 UTRN	1.78e-05	179	80	5	2a53d94f6c30bf887dfe88f1693ea057218c852d
ToppCell	facs-Marrow-T-cells-3m-Myeloid\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	NPC1 MET VPS13C L1CAM DSE	1.88e-05	181	80	5	7286700396676fdc41d9723979b8b408177aceb9
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TIE1 NFATC1 WFS1 TDRD10 RASSF9	1.98e-05	183	80	5	38a54216458ad57f356bb4ddf272e1af8036ddeb
ToppCell	COVID-19-Heart-EC_2\|Heart / Disease (COVID-19 only), tissue and cell type	MET MAST4 PTPRG TIE1 UTRN	2.20e-05	187	80	5	40ffc06a3e3251d9b12da390210d3e045af7537a
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TIE1 WFS1 GRIK3 RASSF9 UTRN	2.20e-05	187	80	5	65d406122dffe18279f14a1ed35ba091730b97be
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TIE1 WFS1 GRIK3 RASSF9 UTRN	2.20e-05	187	80	5	4c15c0ed41a55271fc793cb76fee97fa64190369
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-lymphatic_endothelial_cell-lymphatic_endothelial_cell_of_renal_cortex\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TIE1 WFS1 GRIK3 RASSF9 UTRN	2.20e-05	187	80	5	5274f2b302bbf7fed30c480af4f35058d2cf61e0
ToppCell	E17.5-Endothelial-large_vessel_endothelial_cell\|E17.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PDE4B MAST4 TIE1 PAK5 RASSF9	2.31e-05	189	80	5	360f09f46231a83f99d8fa0158b72a38068e1642
ToppCell	3'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TIE1 NFATC1 WFS1 RASSF9 UTRN	2.37e-05	190	80	5	b2bd2cb384bb8a5662064ed1aee68e905e1f780d
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	TPP2 FMN1 MYOM3 STAT4 MAP3K4	2.43e-05	191	80	5	9bb6a6b88f351217455765ba07a6acf11fda98f4
ToppCell	wk_15-18-Endothelial-Lymph_endothelial-Intermediate_lymphatic_endo\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	MET ABCA4 TIE1 NFATC1 RASSF9	2.43e-05	191	80	5	d25ac3206fe205a100cfee26431ff32c14c1938f
ToppCell	wk_20-22-Endothelial-Lymph_endothelial\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	ABCA4 TIE1 NFATC1 WFS1 RASSF9	2.43e-05	191	80	5	631f95fd80dd3678b5b2ef201abf7fe646049af6
ToppCell	P07-Endothelial-large_vessel_endothelial_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	TIE1 PAK5 RASSF9 BHLHE40 UTRN	2.43e-05	191	80	5	d162917816dd2e4767c97447c1cddae9397713ab
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	TPP2 FMN1 MYOM3 STAT4 MAP3K4	2.49e-05	192	80	5	1c0ce299cee9ab5cdea256f3e8c1e5598577a8b6
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PDE4B TIE1 NFATC1 WFS1 RASSF9	2.55e-05	193	80	5	ef007b736da56529ec628fc3df86a335e7ec3f18
ToppCell	COPD-Multiplet-Multiplet\|COPD / Disease state, Lineage and Cell class	MET CFAP251 MAST4 DCDC1 PTPRG	2.75e-05	196	80	5	af4cdc61830685a888a1209826c23bcf54a43084
ToppCell	wk_15-18-Endothelial-Lymph_endothelial\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	ABCA4 TIE1 NFATC1 WFS1 RASSF9	2.75e-05	196	80	5	ff627244d7f5fd6a2ec009dae32d3509f0e2d95e
ToppCell	COPD-Multiplet\|COPD / Disease state, Lineage and Cell class	MET CFAP251 MAST4 DCDC1 PTPRG	2.75e-05	196	80	5	6d02d494196e3f857d53eea46d9419690d43beca
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Macrophage-macrophage,_alveolar\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MYO1G PDE4B CPVL DSE STAT4	2.82e-05	197	80	5	b17ac6c88dc53e54e04e8a79409d9a0de0be88dc
ToppCell	saliva-Mild-Moderate_progression_d12-25-Myeloid-Macrophage\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MYO1G PDE4B CPVL DSE STAT4	2.82e-05	197	80	5	a22c0f2ffac34635c9c8221aee778e2fc78d672b
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar-AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NPC1 MET MAST4 PTPRG FMN1	2.89e-05	198	80	5	2e2a4e1756bba6f4fbe529559a97d2993c890b4b
ToppCell	Bronchial-10x5prime-Endothelial-Endothelia_vascular-VE_systemic_arterial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	MET MAST4 PTPRG TIE1 MYOM3	2.96e-05	199	80	5	6a2943a23fdd2ec814662db7c21a0d6804a6cbbc
ToppCell	facs-Pancreas-Exocrine-18m-Epithelial-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HSD17B7 FMN1 L1CAM GAN	1.09e-04	137	80	4	e9b88ad86b75454a8292a94879c5b665adc42744
ToppCell	control-dn_T\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	MET GTSF1 CD248 IBA57-DT	1.43e-04	147	80	4	68258498202c7f580f72c46dd645071835098455
ToppCell	facs-Lung-Endomucin-3m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1G L1CAM SLC36A3 DSE	1.84e-04	157	80	4	0ad242320ada7bcb9e29548d3050bf4fd3a07115
ToppCell	severe_COVID-19-MAIT\|severe_COVID-19 / disease group, cell group and cell class (v2)	ELOVL4 ABCA2 BHLHE40 STAT4	1.84e-04	157	80	4	175f637e9707836bd63b5c2ccc9d4eb601c05b9e
ToppCell	facs-Lung-Endomucin-3m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1G L1CAM SLC36A3 DSE	1.84e-04	157	80	4	fe4c9556806203e57522d1986754ebe5a20aa2de
ToppCell	Control-Lymphocyte-T_NK-dnT\|Control / Disease, Lineage and Cell Type	MET GTSF1 RPTOR IBA57-DT	1.88e-04	158	80	4	7a2fad6426549d910834debfe5e102fe2ab5976d
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Lymphocytic-T_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MYO1G MET NFATC1 ARRDC4	1.97e-04	160	80	4	cfd005e98944817458e8ef9e0c436d77f50c1ad1
ToppCell	Children_(3_yrs)-Epithelial-lung_goblet_cell-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	MET GRIK3 RASSF9 PADI3	2.02e-04	161	80	4	2d63b279d9a5132e1c09b03930bf9039036d24a2
ToppCell	Bronchial_Biopsy-Endothelial-Lymphatic\|Endothelial / Tissue, Lineage and Cell class of Lung Cells from 10X	ABCA4 DTX4 VASH2 PADI3	2.12e-04	163	80	4	961c3a1303108afd680365466045f3460a30a7b0
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT3LG BHLHE40 DSE STAT4	2.17e-04	164	80	4	9fed5df40f50bde35db8bf89c291cbdc0e104112
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FLT3LG BHLHE40 DSE STAT4	2.17e-04	164	80	4	e712d6b89461f741dbd773ba9a27ecaddf97cbaa
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c09-SLC4A10\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	ELOVL4 FLT3LG BHLHE40 STAT4	2.22e-04	165	80	4	5e7ee76f3dcddbd1b560bacd043f9001b0c18b5f
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PDE4B TIE1 NFATC1 RASSF9	2.27e-04	166	80	4	941d6aa94ab9d36e5f6c40f446c926754e070d56
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PDE4B TIE1 NFATC1 RASSF9	2.27e-04	166	80	4	6f5ecf3b2cf613ae0535ab3d21d93622f1497571
ToppCell	343B-Myeloid-Dendritic-pDC\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	PTPRG TCL1A VASH2 RTKN	2.43e-04	169	80	4	632aa3ab39ec87bafcefec6cddf71129a054d3b0
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_3\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	COL4A4 MET ABCA4 APCS	2.49e-04	170	80	4	5d5f208682be21ed58320f5fc083a7898f8712da
ToppCell	control-dn_T\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	MET GTSF1 CD248 IBA57-DT	2.49e-04	170	80	4	839f62860b4a52d06e6a8fce7632195c7310b89d
ToppCell	3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-ENCC/glia_Progenitor\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SLC6A7 PAK5 L1CAM GRIK3	2.54e-04	171	80	4	b51bbeacb172e8b5de519ada85543d7ae9914b3c
ToppCell	Healthy/Control-Plasmablast\|World / Disease group and Cell class	MET PTPRG WFS1 CCDC187	2.60e-04	172	80	4	d3bfcf5d936152b71cd90f955f9331709edd979e
ToppCell	10x3'2.3-week_12-13-Lymphocytic_NK-T_NK-NK_progenitor\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	ELOVL4 FLT3LG TEF UTRN	2.60e-04	172	80	4	a126dacd94939851de1403d30f0b63eaad48bfa1
ToppCell	Mild/Remission-B_naive-8\|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)	ARRDC4 TCL1A CCDC187 UTRN	2.66e-04	173	80	4	694d02c4d2dc2de4b344544f9124fec40fcf7d8f
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-4_RORB_SEMA6D\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC6A7 MET FMN1 UTRN	2.66e-04	173	80	4	9a2d42f8d9cb834856522661d524abb91c4637c5
ToppCell	tumor_Lymph_Node_/_Brain-B_lymphocytes-Undetermined\|B_lymphocytes / Location, Cell class and cell subclass	MET PTPRG SH3GLB2 STAT4	2.72e-04	174	80	4	390bd41ef114464f3db3e0cac4e67fe7571b4c23
ToppCell	Multiple_Sclerosis-Lymphocyte-T_NK-CD4_TEM\|Multiple_Sclerosis / Disease, Lineage and Cell Type	ELOVL4 FLT3LG PDE4B STAT4	2.72e-04	174	80	4	d2ea5b55bf03a8013816d073896208f311c3e544
ToppCell	Severe-B_naive-8\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	TCL1A DTX4 CCDC187 UTRN	2.72e-04	174	80	4	f3f8c924420f46321bd47e2b97f18c7241541599
ToppCell	Healthy_donor-Plasmablast\|World / disease group, cell group and cell class (v2)	MET SLC22A9 PTPRG WFS1	2.78e-04	175	80	4	5293e00fda63a291aa393bdf82ebd4b80265049f
ToppCell	B_cells-pDCs\|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis	NPC1 ABCA2 FMN1 VASH2	2.84e-04	176	80	4	ce757de9e09a225f3f96433f103f43619b0e0dda
ToppCell	10x3'2.3-week_14-16-Lymphocytic_T-T_NK-NK_T_cell\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	ELOVL4 COL4A4 FLT3LG STAT4	2.84e-04	176	80	4	f0c01fc4f9c17c4d724642d9931731eef2b10258
ToppCell	3'-Adult-LargeIntestine-Endothelial-lymphatic_endothelial-LEC3_(ADGRG3+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABCA4 TIE1 WFS1 IBA57-DT	2.84e-04	176	80	4	5d3b2395bb842eea39175f5af6a4c76527e2fc31
ToppCell	3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CFAP251 DCDC1 FER1L5 CFAP65	2.84e-04	176	80	4	dee780cfa85234a7cd7bf440b66b84cec959893e
ToppCell	metastatic_Brain-B_lymphocytes-GrB-secreting_B_cells\|B_lymphocytes / Location, Cell class and cell subclass	NPC1 FMN1 VASH2 BHLHE40	2.90e-04	177	80	4	43e1d0d3cf8f0c02e67d91f8dd1761df23d59e07
ToppCell	Ciliated_cells-B-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	CFAP251 DCDC1 CCDC187 CFAP119	2.90e-04	177	80	4	c38138fb5ad9766c2d240811210c854338cd612e
ToppCell	Fetal_29-31_weeks-Epithelial-ciliated_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CFAP251 DCDC1 CCDC187 CFAP65	2.96e-04	178	80	4	de5d50d7ca9ee9eb62f50c88a0c6d47f0694b2e6
ToppCell	Healthy_donor-Plasmablast\|Healthy_donor / disease group, cell group and cell class (v2)	MET SLC22A9 PTPRG WFS1	2.96e-04	178	80	4	388b8b4fa20dcc6e9ae4b06118e20b2c20c52bde
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC6A7 MET SLC22A9 ABCA4	2.96e-04	178	80	4	731e1e8eff2c4018c75dfc66632a316010a09a9a
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_HNRNPA1P46\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC22A9 FMN1 GRIK3 UTRN	3.03e-04	179	80	4	c815eb9f760fe4ca7a5e49beb224659f0b864f22
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TIE1 WFS1 RASSF9 UTRN	3.03e-04	179	80	4	abc6797bd3884aa75dca58fcb2523ee321243ab1
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TIE1 WFS1 RASSF9 UTRN	3.03e-04	179	80	4	0b996d6e881f31e6b80d359f7caac70ecdeb9982
ToppCell	PCW_10-12-Endothelial-Endothelial_mature-lymphatic\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ABCA4 TIE1 TDRD10 RASSF9	3.03e-04	179	80	4	ab3d08b51cd7a37582305615ee221c7a2af83b40
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	SLC6A13 NEU4 MAST4 MYOM3	3.03e-04	179	80	4	d1ef7e1cb00336118e387b47f4f8120f53584391
ToppCell	PCW_10-12-Endothelial-Endothelial_mature-lymphatic-endo_lymphatic_(7)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	ABCA4 TIE1 TDRD10 RASSF9	3.03e-04	179	80	4	35fe9961e228ce255e3317fc244efa35b5adbf8b
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC6A7 MET MAST4 FMN1	3.09e-04	180	80	4	5391d23817f5cc88a0871ddb98968897c839f464
ToppCell	PCW_05-06-Endothelial-Endothelial_mature-endo_arterial_(9)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	MET TIE1 TDRD10 BHLHE40	3.09e-04	180	80	4	5861b44acfb8fe92c281c8355bf19c059b3dcd64
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial-neuronal_stem_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ELOVL4 NEU4 PAK4 PLEKHA6	3.16e-04	181	80	4	4e81ec1580e9acb22c32c465eb46f83d1e9e424e
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ELOVL4 NEU4 PAK4 PLEKHA6	3.16e-04	181	80	4	ad30c01290fb98adbd0caed301a584761212c977
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC6A7 MET SLC22A9 ABCA4	3.16e-04	181	80	4	6e8c5460021d3999daec58e3d6661a6fa998fd16
ToppCell	Endothelial-B-IPF_02\|World / lung cells shred on cell class, cell subclass, sample id	TIE1 NFATC1 WFS1 RASSF9	3.16e-04	181	80	4	4fe0215d08f03d4e24749d70fce01b7aa22906fd
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Epithelial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ELOVL4 NEU4 PAK4 PLEKHA6	3.16e-04	181	80	4	3a3268a4dff8ffcb79e09f46490e138c96f8d916
ToppCell	Fetal_29-31_weeks-Epithelial-ciliated_cell-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CFAP251 DCDC1 CFAP119 CFAP65	3.16e-04	181	80	4	dfce05bd472f67e6e2bb60ebd6fd34f0a9aeeca6
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L2-4_RORB_GRIK1\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SLC6A7 MET UTRN STAT4	3.16e-04	181	80	4	57994ff4ecffb15653aee00644d9f887f5e3461d
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T-MAIT-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ELOVL4 FLT3LG BHLHE40 STAT4	3.22e-04	182	80	4	f30e5a21b49f30b82e2b6f1fd2daefd805a40083
ToppCell	Adult-Epithelial-ciliated_cell-D122\|Adult / Lineage, Cell type, age group and donor	CFAP251 DCDC1 CCDC187 CFAP65	3.22e-04	182	80	4	7ded554a4b441e6496db673ba206c0d76ccad7d9
ToppCell	Control-Epithelial_cells-Airway_ciliated\|Control / group, cell type (main and fine annotations)	CFAP251 DCDC1 CCDC187 CFAP65	3.22e-04	182	80	4	fb725d10d9ed25dfc6d5bb69cfef78513f7d3e8f
ToppCell	COVID-19_Severe-Lymphoid_T/NK-MAIT\|COVID-19_Severe / Disease group, lineage and cell class	ELOVL4 FLT3LG BHLHE40 STAT4	3.22e-04	182	80	4	19045db5c726c06ec6e4feb4311633c8164ddb3c
ToppCell	5'-Airway_Nasal-Immune_Myeloid-Myeloid_monocytic-classical_monocyte-Classical_monocytes-Classical_monocytes_L.1.2.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MYO1G PDE4B CPVL DSE	3.22e-04	182	80	4	c3eafdc11858566aa7692b2f5dbe72ac01fb769a
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T-MAIT-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ELOVL4 FLT3LG BHLHE40 STAT4	3.22e-04	182	80	4	cccac9f85825f4e310b86e37ee6320769a670501
ToppCell	3'-Adult-LymphNode-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABCA4 TIE1 NFATC1 RASSF9	3.22e-04	182	80	4	82d6f72649c7dd4d64a84a9795edebdef2f285d6
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TIE1 TDRD10 RASSF9 UTRN	3.22e-04	182	80	4	d0e3663f7d39f22a3ebd7fde56ab3504773598f4
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T-MAIT\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ELOVL4 FLT3LG BHLHE40 STAT4	3.22e-04	182	80	4	1444cdc4522a70a40d697ccadf54cf26d327ade0
ToppCell	PBMC-Severe-Lymphocyte-T/NK-CD8+_T-MAIT\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	ELOVL4 FLT3LG BHLHE40 STAT4	3.22e-04	182	80	4	49eced222e8f90c2b59bcc7d56b62c3e703fcce5
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	TIE1 NFATC1 WFS1 RASSF9	3.29e-04	183	80	4	764ea07621f77fbd13a877aed5806ae2b3dfb43e
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Hematopoietic-T_cells-LTi-like_NCR+_ILC3\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYO1G GTSF1 NFATC1 STAT4	3.29e-04	183	80	4	c7fedb5b0c1f17b3391ce1c4a6bfca7615c359c5
ToppCell	wk_08-11-Hematologic_Lymphocytic-T_&_ILC-ILCP\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	MYO1G GTSF1 FLT3LG NFATC1	3.29e-04	183	80	4	797eb968c57e48db33ff8e2236ee22e9425c4676
ToppCell	Nasal_Brush-Immune-Dendritic_cells\|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	MYO1G GTSF1 PDE4B CPVL	3.29e-04	183	80	4	b1daec831990a53e846c089cebfcf4f8440820e4
ToppCell	Children_(3_yrs)-Epithelial-ciliated_cell-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CFAP251 DCDC1 CCDC187 CFAP65	3.36e-04	184	80	4	5daff849625f2f41d56615569c0ed59cd733b34c
ToppCell	Adult-Epithelial-ciliated_cell-D175\|Adult / Lineage, Cell type, age group and donor	CFAP251 DCDC1 CCDC187 CFAP65	3.43e-04	185	80	4	30f4980dee6cd5959655f8d74049f3bfb5312611
ToppCell	5'-GW_trimst-2-SmallIntestine-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABCA4 TIE1 NFATC1 RASSF9	3.43e-04	185	80	4	241ea1e178fffef9e7df971de739e794332d5173
ToppCell	Fetal_29-31_weeks-Epithelial-ciliated_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CFAP251 DCDC1 CCDC187 CFAP65	3.43e-04	185	80	4	3e39a3cb534dfe2301930f3e2f7e8cefb522c158
ToppCell	COVID-19-Epithelial_cells-Airway_ciliated\|COVID-19 / group, cell type (main and fine annotations)	CFAP251 DCDC1 CCDC187 CFAP65	3.43e-04	185	80	4	18a40f0a338aa398d81384b5159fb80ce8a2020c
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Endothelial-blood_vessel_EC-Fetal_venous_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PDE4B TIE1 TDRD10 RASSF9	3.50e-04	186	80	4	055cc23c4db9aad2d6c62e62c8e58bfe5047c6b1
ToppCell	5'-Adult-SmallIntestine-Endothelial-lymphatic_endothelial-LEC5_(CLDN11+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ABCA4 TIE1 NFATC1 RASSF9	3.50e-04	186	80	4	9579180db2a0bf3f043b4d169f9a08cdc45b459a
ToppCell	facs-Lung-ENDOMUCIN-18m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ELOVL4 TIE1 BHLHE40 UTRN	3.50e-04	186	80	4	5302399825f213d105ac70b91366a4513b732838
ToppCell	wk_20-22-Hematologic_Lymphocytic-T_&_ILC-ILC2\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	MYO1G FLT3LG BHLHE40 STAT4	3.57e-04	187	80	4	dd5183d2c620b2a87253a9783b70c5df2c36c570
ToppCell	Fetal_29-31_weeks-Epithelial-ciliated_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CFAP251 DCDC1 CCDC187 CFAP65	3.57e-04	187	80	4	9e10ed56090d82589bc457788282f664b70ace4b
Disease	Stargardt disease (implicated_via_orthology)	ELOVL4 ABCA4	6.72e-06	2	77	2	DOID:0050817 (implicated_via_orthology)
Disease	Stargardt disease	ELOVL4 ABCA4	2.01e-05	3	77	2	cv:C0271093
Disease	autosomal recessive spinocerebellar ataxia 4 (implicated_via_orthology)	VPS13D VPS13C	2.01e-05	3	77	2	DOID:0111611 (implicated_via_orthology)
Disease	Long Qt Syndrome 2	ALG10 ALG10B	2.01e-05	3	77	2	C3150943
Disease	STARGARDT DISEASE 1 (disorder)	ELOVL4 ABCA4	6.69e-05	5	77	2	C1855465
Disease	nonsyndromic deafness (implicated_via_orthology)	ALG10 ALG10B	1.00e-04	6	77	2	DOID:0050563 (implicated_via_orthology)
Disease	Stargardt's disease	ELOVL4 ABCA4	1.00e-04	6	77	2	C0271093
Disease	glutamine measurement	TNPO1 SLC6A13 SLC36A3 PLEKHA6	1.24e-04	97	77	4	EFO_0009768
Disease	Thyroid preparation use measurement	TNPO1 NFATC1 TEF BHLHE40 STAT4	2.64e-04	217	77	5	EFO_0009933
Disease	level of Phosphatidylinositol (16:0_18:1) in blood serum	RRN3 DOCK7	4.36e-04	12	77	2	OBA_2045152
Disease	cholangiocarcinoma (biomarker_via_orthology)	MET EPOR	5.15e-04	13	77	2	DOID:4947 (biomarker_via_orthology)
Disease	Parkinson's disease (implicated_via_orthology)	RRN3 VPS13C PAK5 PAK4	7.72e-04	157	77	4	DOID:14330 (implicated_via_orthology)
Disease	C-reactive protein measurement	NPC1 PGS1 CFAP251 PDE4B CD248 VPS13C DOCK7 APCS TDRD10 TEF	1.14e-03	1206	77	10	EFO_0004458
Disease	coagulation factor V measurement	MAST4 PAK5	1.24e-03	20	77	2	EFO_0008087
Disease	leptin measurement	ALG10 CPVL ALG10B	1.26e-03	81	77	3	EFO_0005000
Disease	body weight	NPC1 PDE4B MAST4 PTPRG VPS13C PAK5 PPIL1 RRH CPVL NUP160	1.59e-03	1261	77	10	EFO_0004338
Disease	Hereditary Paraganglioma-Pheochromocytoma Syndrome	MET SDHC	1.64e-03	23	77	2	C1708353
Disease	beta-aminoisobutyric acid measurement	SLC6A13 BHLHE40	1.79e-03	24	77	2	EFO_0010464
Disease	amino acid measurement	SLC6A13 DCDC1 PTPRG ARRDC4 FMN1 GAN MAP3K4	1.96e-03	678	77	7	EFO_0005134
Disease	triglycerides:total lipids ratio, high density lipoprotein cholesterol measurement	DXO PGS1 RRN3 DOCK7	2.10e-03	206	77	4	EFO_0004612, EFO_0020947
Disease	alcohol use disorder measurement, alcohol consumption measurement	PDE4B TEF NUP160	2.11e-03	97	77	3	EFO_0007878, EFO_0009458
Disease	Vitiligo	TEF CPVL STAT4	2.37e-03	101	77	3	EFO_0004208

Protein segments in the cluster

Peptide	Gene	Start	Entry
WPDMGVPEYALPVLT	PTPRG	1026	P23470
TPWNIFPVISLYLMG	BACE1	336	P56817
WVSMQPQPLLPPTYF	CCDC187	901	A0A096LP49
VVFPDMYPWTSSLPP	ABCA4	551	P78363
LPMLEKCWYPTSVPV	BHLHE40	336	O14503
LWMEPTQPPDFALAY	CD248	396	Q9HCU0
YWLASAAPLPMMPLS	COL4A4	1541	P53420
VEPMLWNPSGTPKRY	C22orf31	221	O95567
SQWDPMITTLPGLYL	ALG10B	56	Q5I7T1
YPMVTGTLPKAQSWP	DTX4	161	Q9Y2E6
DHPYPTTKLMWIPDT	DCAF7	66	P61962
MSWLTLTLPEQPEAP	ARRDC4	336	Q8NCT1
PTCMVWYPPLTRELF	CFAP251	796	Q8TBY9
WELSPANYMKTLPPD	RASSF9	141	O75901
IEPSCPMKPLYWTRI	FMN1	976	Q68DA7
ALMPIIGWASYAPDP	RRH	156	O14718
DLQWVLTDGPNPPYM	NCSTN	81	Q92542
TPYWMAPEVISRLPY	PAK5	606	Q9P286
PLWNKLTYMWPVLPS	DCDC1	886	M0R2J8
PLMQSPWPTLSISTL	ELOVL4	41	Q9GZR5
SGMRVPKSLPYVLPW	GTSF1	146	Q8WW33
YLMPILPVPSSSWED	CFAP65	1726	Q6ZU64
PWTTTLSMLYIDNPV	CPVL	141	Q9H3G5
YPLLSSPVQWPLSLV	IBA57-DT	16	B1ANH7
MTVLAPAWSPTTYLL	FLT3LG	1	P49771
APDTWIYPLIQMKPF	PGS1	346	Q32NB8
WYQSMIPQSPSPPLD	PDE4B	651	Q07343
PFESPIWRMYPNSTV	MS4A10	151	Q96PG2
SYMSPTLPALDWQLP	NFATC1	406	O95644
NWIRPTLGIPTYVMS	HERVK_113	276	P63132
HTMLSSPLEYLPPWD	DSE	76	Q9UL01
PPSAEPLRIYWMNSK	L1CAM	161	P32004
WIMTPSTLPPLEVYV	PADI3	296	Q9ULW8
PIKTSWTPPRYVLSM	DDX41	141	Q9UJV9
MPFAAPPQSPTWLLY	NEU4	366	Q8WWR8
NWIRPTLGIPTYAMS	ERVK-7	276	P63135
NWIRPTLGIPTYAMS	ERVK-6	276	Q9BXR3
IWYVEAMTQDLPSPP	DXO	376	O77932
PPAPWTILGLDAMYV	NPC1	256	O15118
NWIRPTLGIPTYAMS	ERVK-18	276	Q9QC07
LTYMGLQPPKLWPES	CFAP119	226	A1A4V9
TPLETPVGYTWIPML	DOCK7	661	Q96N67
KYDPDANTWTALPPM	GAN	346	Q9H2C0
PLSPHITIYSWSLPM	SDHC	51	Q99643
ITPIMYPASFWFEVP	ABCA2	1886	Q9BZC7
TYGILPPFIWTLLMP	HSD17B7	231	P56937
MNKSYLLEPWFLPPS	MAST4	1866	O15021
WLPPPETPMTSHIRY	EPOR	166	P19235
PPGDTTTIIPLNWML	nan	16	Q6ZN92
SFLNPLSPDIWMYVL	GRIK3	556	Q13003
WMAPELISRLPYGPE	PAK4	481	O96013
TSAPAPNAYTMPPLW	ODF3L2	156	Q3SX64
PMWGSDYVQLSRTPP	MAP3K4	576	Q9Y6R4
VLLWELMTRGAPPYP	MET	1271	P08581
LETPPPWLAMFTDQP	RTKN	476	Q9BST9
YVPSTPWFLMPILVE	RRN3	196	Q9NYV6
PITLISMWPEHYDPS	UTRN	3166	P46939
LAMSWIKPQLQLYPP	FER1L5	1986	A0AVI2
WDEGYSTPSIPPEML	NBPF9	561	P0DPF3
LMMILSVYSPPLPWI	SLC22A9	486	Q8IVM8
DDFWTIPPLTQPFML	TDRD10	301	Q5VZ19
LITVYSLPGMDPDWL	SH3GLB2	361	Q9NR46
ASLMPPIWDKTIPYD	TEF	76	Q10587
IEFPLSATAPMVWLP	NUP160	1371	Q12769
PLSIYDLQTWMGSPS	RPTOR	176	Q8N122
YPQAMTMLPLSPFWS	SLC6A7	371	Q99884
EGIPYPSNLPLMANW	SLC36A3	236	Q495N2
QIGPSLLPIMWQLYP	TCL1A	66	P56279
SQWDPMITTLPGLYL	ALG10	56	Q5BKT4
PDLTLSYLSMWLHQP	CINP	176	Q9BW66
NWIRPTLGIPTYAMS	ERVK-25	276	P63136
SMPAYDRISPPWALE	PLEKHA6	376	Q9Y2H5
LYMWDSVLPPENILS	APCS	176	P02743
PDSWQPPNVYLETSM	PPIL1	6	Q9Y3C6
WTETYPQTPPILSMN	RWDD4	51	Q6NW29
TLMTTDCPEPLLQPW	TIE1	536	P35590
PPPATLSQLLEVMSW	STAT4	486	Q14765
AYPRAVVMLPFSPLW	SLC6A13	361	Q9NSD5
NWIRPTLGIPTYAMS	ERVK-10	276	P10266
ASFTENWLPIMYPPD	TPP2	1231	P29144
NWIRPTLGIPTYAMS	ERVK-11	276	Q9UQG0
PQVPNYRLSMTIPDW	VASH2	96	Q86V25
PALIMNHTPWDILTY	VPS13C	2976	Q709C8
LSSPYDVPTWMPQLL	PSME4	1771	Q14997
WVVSQPPDTYLKPLM	TNPO1	476	Q92973
GLLSLLPSMPLNWPY	WFS1	466	O76024
MTSLDYAWDEPTLPP	VPS13D	3546	Q5THJ4
LLYNSTDPTLRAMWP	MYO1G	546	B0I1T2
TSLVLQWEPPLYMGA	MYOM3	816	Q5VTT5