Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	cytoskeletal protein binding	KIF21B FLII MYH8 CCDC88A TIAM1 XIRP2 KIF19 SVBP LRRK2 NUMA1 TMOD4 MYO1B CCDC181 CROCC PALLD	9.99e-06	1099	74	15	GO:0008092
GeneOntologyMolecularFunction	microtubule binding	KIF21B CCDC88A TIAM1 KIF19 SVBP LRRK2 NUMA1 CCDC181	1.82e-05	308	74	8	GO:0008017
GeneOntologyMolecularFunction	small GTPase binding	IPO9 RGPD8 LRRK2 DVL1 DVL3 PEX5 GOLGA5 CYRIB	2.45e-05	321	74	8	GO:0031267
GeneOntologyMolecularFunction	GTPase binding	IPO9 RGPD8 LRRK2 DVL1 DVL3 PEX5 GOLGA5 CYRIB	5.52e-05	360	74	8	GO:0051020
GeneOntologyMolecularFunction	actin binding	FLII MYH8 CCDC88A XIRP2 LRRK2 TMOD4 MYO1B CROCC PALLD	6.77e-05	479	74	9	GO:0003779
GeneOntologyMolecularFunction	cytoskeletal motor activity	KIF21B DNHD1 MYH8 KIF19 MYO1B	7.70e-05	118	74	5	GO:0003774
GeneOntologyMolecularFunction	tubulin binding	KIF21B CCDC88A TIAM1 KIF19 SVBP LRRK2 NUMA1 CCDC181	1.83e-04	428	74	8	GO:0015631
GeneOntologyMolecularFunction	calcium-dependent protein serine/threonine kinase activity	MKNK2 MAPKAPK5	5.98e-04	10	74	2	GO:0009931
GeneOntologyMolecularFunction	co-receptor binding	BMP2 LRRK2	1.03e-03	13	74	2	GO:0039706
GeneOntologyMolecularFunction	phosphatidylinositol binding	FLII CCDC88A NUMA1 SNX27 MYO1B NCF4	1.12e-03	316	74	6	GO:0035091
GeneOntologyMolecularFunction	calmodulin binding	MYH8 MKNK2 MYO1B MAPKAPK5 PCNT	1.64e-03	230	74	5	GO:0005516
GeneOntologyCellularComponent	Wnt signalosome	LRRK2 DVL1 DVL3	2.21e-05	16	73	3	GO:1990909
GeneOntologyCellularComponent	growth cone	LRIG2 KIF21B TIAM1 LRRK2 DVL1 EXOC3 PALLD	2.35e-05	245	73	7	GO:0030426
GeneOntologyCellularComponent	site of polarized growth	LRIG2 KIF21B TIAM1 LRRK2 DVL1 EXOC3 PALLD	2.89e-05	253	73	7	GO:0030427
GeneOntologyCellularComponent	centrosome	FLII CCDC88A LATS2 TIAM1 CEP250 UBXN6 NUMA1 CROCC TSEN2 RBM39 PCNT	6.99e-05	770	73	11	GO:0005813
GeneOntologyCellularComponent	supramolecular fiber	KIF21B MYH8 TIAM1 XIRP2 RP1L1 KIF19 NUMA1 DVL1 TMOD4 MYO1B CCDC181 PALLD PCNT	2.00e-04	1179	73	13	GO:0099512
GeneOntologyCellularComponent	supramolecular polymer	KIF21B MYH8 TIAM1 XIRP2 RP1L1 KIF19 NUMA1 DVL1 TMOD4 MYO1B CCDC181 PALLD PCNT	2.13e-04	1187	73	13	GO:0099081
GeneOntologyCellularComponent	cilium	DNHD1 FSIP2 CCDC88A TIAM1 CEP250 RP1L1 KIF19 CCDC181 CROCC CYRIB PCNT	2.69e-04	898	73	11	GO:0005929
GeneOntologyCellularComponent	microtubule organizing center	FLII CCDC88A LATS2 TIAM1 CEP250 UBXN6 NUMA1 CROCC TSEN2 RBM39 PCNT	3.28e-04	919	73	11	GO:0005815
GeneOntologyCellularComponent	microtubule	KIF21B TIAM1 RP1L1 KIF19 NUMA1 DVL1 CCDC181 PCNT	5.32e-04	533	73	8	GO:0005874
GeneOntologyCellularComponent	distal axon	LRIG2 KIF21B TIAM1 LRRK2 DVL1 EXOC3 PALLD	8.04e-04	435	73	7	GO:0150034
GeneOntologyCellularComponent	centriolar satellite	FLII LATS2 RBM39 PCNT	1.05e-03	128	73	4	GO:0034451
GeneOntologyCellularComponent	polymeric cytoskeletal fiber	KIF21B TIAM1 RP1L1 KIF19 NUMA1 DVL1 MYO1B CCDC181 PALLD PCNT	1.10e-03	899	73	10	GO:0099513
Domain	Dishevelled_fam	DVL1P1 DVL1 DVL3	2.29e-07	4	73	3	IPR008339
Domain	Dishevelled	DVL1P1 DVL1 DVL3	2.29e-07	4	73	3	PF02377
Domain	Dishevelled_protein_dom	DVL1P1 DVL1 DVL3	2.29e-07	4	73	3	IPR003351
Domain	DIX	DVL1P1 DVL1 DVL3	1.98e-06	7	73	3	PF00778
Domain	DIX	DVL1P1 DVL1 DVL3	1.98e-06	7	73	3	IPR001158
Domain	DIX	DVL1P1 DVL1 DVL3	1.98e-06	7	73	3	PS50841
Domain	DAX	DVL1P1 DVL1 DVL3	1.98e-06	7	73	3	SM00021
Domain	DVL-1	DVL1P1 DVL1	1.51e-05	2	73	2	IPR008340
Domain	Dsh_C	DVL1 DVL3	4.51e-05	3	73	2	PF12316
Domain	Dishevelled_C-dom	DVL1 DVL3	4.51e-05	3	73	2	IPR024580
Domain	DEP	DVL1P1 DVL1 DVL3	8.36e-05	22	73	3	PF00610
Domain	DEP	DVL1P1 DVL1 DVL3	8.36e-05	22	73	3	PS50186
Domain	DEP	DVL1P1 DVL1 DVL3	8.36e-05	22	73	3	SM00049
Domain	Dsh/Dvl-rel	DVL1 DVL3	9.00e-05	4	73	2	IPR015506
Domain	DEP_dom	DVL1P1 DVL1 DVL3	9.59e-05	23	73	3	IPR000591
Domain	UBA-like	USP13 TDRD3 LATS2 DMRTA1	1.14e-04	64	73	4	IPR009060
Domain	PDZ	DVL1P1 TIAM1 DVL1 DVL3 SNX27	2.27e-04	141	73	5	PF00595
Domain	PDZ	DVL1P1 TIAM1 DVL1 DVL3 SNX27	2.84e-04	148	73	5	SM00228
Domain	PDZ	DVL1P1 TIAM1 DVL1 DVL3 SNX27	3.12e-04	151	73	5	PS50106
Domain	PDZ	DVL1P1 TIAM1 DVL1 DVL3 SNX27	3.22e-04	152	73	5	IPR001478
Domain	UBA	USP13 TDRD3 LATS2	3.73e-04	36	73	3	PF00627
Domain	LRR_8	LRIG2 FLII TLR3 LRRK2 LRRC69	5.51e-04	171	73	5	PF13855
Domain	Leu-rich_rpt_typical-subtyp	LRIG2 FLII TLR3 LRRK2 LRRC69	6.45e-04	177	73	5	IPR003591
Domain	LRR_TYP	LRIG2 FLII TLR3 LRRK2 LRRC69	6.45e-04	177	73	5	SM00369
Domain	Leu-rich_rpt_4	FLII LRRK2	6.64e-04	10	73	2	IPR025875
Domain	LRR_4	FLII LRRK2	6.64e-04	10	73	2	PF12799
Domain	UBA	USP13 TDRD3 LATS2	6.76e-04	44	73	3	IPR015940
Domain	Ubiquitin-rel_dom	UBXN6 DVL1 DVL3 SNX27 UHRF2	7.68e-04	184	73	5	IPR029071
Domain	Grip	RGPD8 RGPD5	8.10e-04	11	73	2	SM00755
Domain	GRIP	RGPD8 RGPD5	8.10e-04	11	73	2	PF01465
Domain	UBA	USP13 TDRD3 LATS2	8.21e-04	47	73	3	PS50030
Domain	Ran_BP1	RGPD8 RGPD5	9.70e-04	12	73	2	PF00638
Domain	GRIP_dom	RGPD8 RGPD5	9.70e-04	12	73	2	IPR000237
Domain	GRIP	RGPD8 RGPD5	9.70e-04	12	73	2	PS50913
Domain	RANBD1	RGPD8 RGPD5	9.70e-04	12	73	2	PS50196
Domain	LRR	LRIG2 FLII TLR3 LRRK2 LRRC69	1.14e-03	201	73	5	PS51450
Domain	RanBD	RGPD8 RGPD5	1.14e-03	13	73	2	SM00160
Domain	Ran_bind_dom	RGPD8 RGPD5	1.14e-03	13	73	2	IPR000156
Domain	TUDOR	TDRD3 TDRD10	1.33e-03	14	73	2	PF00567
Domain	-	LRIG2 FLII TLR3 LRRK2 LRRC69 TMOD4	1.59e-03	321	73	6	3.80.10.10
Domain	P-loop_NTPase	KIF21B DNHD1 MYH8 BRIP1 CLPB GBP7 KIF19 LRRK2 MYO1B ABCB1	1.64e-03	848	73	10	IPR027417
Domain	LRR_1	LRIG2 FLII TLR3 LRRK2 LRRC69	1.67e-03	219	73	5	PF00560
Domain	L_dom-like	LRIG2 FLII TLR3 LRRK2 LRRC69 TMOD4	1.78e-03	328	73	6	IPR032675
Domain	Prefoldin	KIF21B RNF20 CROCC	2.82e-03	72	73	3	IPR009053
Domain	-	TIAM1 DVL1 DVL3 SNX27	2.83e-03	150	73	4	2.30.42.10
Domain	TUDOR	TDRD3 TDRD10	3.61e-03	23	73	2	PS50304
Domain	tRNA-bd_arm	CROCC CUX1	3.93e-03	24	73	2	IPR010978
Domain	Leu-rich_rpt	LRIG2 FLII TLR3 LRRK2 LRRC69	4.17e-03	271	73	5	IPR001611
Domain	TPR_1	RGPD8 PEX5 RGPD5	5.28e-03	90	73	3	PF00515
Domain	TPR_1	RGPD8 PEX5 RGPD5	5.28e-03	90	73	3	IPR001440
Domain	Tudor	TDRD3 TDRD10	6.11e-03	30	73	2	IPR002999
Domain	UBA	USP13 TDRD3	6.11e-03	30	73	2	SM00165
Domain	LRRCT	LRIG2 TLR3	6.93e-03	32	73	2	PF01463
Pubmed	cDNA characterization and chromosomal mapping of two human homologues of the Drosophila dishevelled polarity gene.	DVL1P1 DVL1 DVL3	4.00e-08	4	76	3	8817329
Pubmed	Human dishevelled genes constitute a DHR-containing multigene family.	DVL1P1 DVL1 DVL3	4.00e-08	4	76	3	9192851
Pubmed	Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways.	LRRK2 DVL1 DVL3	4.00e-08	4	76	3	19625296
Pubmed	CYLD regulates spindle orientation by stabilizing astral microtubules and promoting dishevelled-NuMA-dynein/dynactin complex formation.	NUMA1 DVL1 DVL3	1.00e-07	5	76	3	24469800
Pubmed	Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.	IGF2BP2 MIA3 CEP250 RNF20 TIMELESS HERC1 GOLGA5 PCNT	2.15e-07	285	76	8	32838362
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	TDRD3 IGF2BP2 MIA3 CCDC88A IPO9 TIAM1 SNX27 EXOC3 MYO1B HERC1 GOLGA5 NOTCH1 PCNT	4.18e-07	1049	76	13	27880917
Pubmed	A Conserved Role for Girdin in Basal Body Positioning and Ciliogenesis.	CCDC88A CEP250 CROCC	5.57e-07	8	76	3	27623382
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	FLII TDRD3 IGF2BP2 MIA3 RGPD8 CLPB DVL1 MRPL10 PEX5 HERC1 GOLGA5 QRSL1 RBM39 CUX1 PCNT	7.14e-07	1496	76	15	32877691
Pubmed	LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6.	LRRK2 DVL1 DVL3	8.34e-07	9	76	3	22899650
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	DNHD1 RGPD8 CEP250 NUMA1 MYO1B HERC1 RBM39	8.41e-07	234	76	7	36243803
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	LRIG2 KIF21B FLII TDRD3 MIA3 CCDC88A RGPD8 NUMA1 PEX5 CYRIB CUX1 PCNT	1.16e-06	963	76	12	28671696
Pubmed	Dishevelled 2 is essential for cardiac outflow tract development, somite segmentation and neural tube closure.	DVL1 DVL3 NOTCH1	2.17e-06	12	76	3	12421720
Pubmed	The Hippo pathway regulates Wnt/beta-catenin signaling.	LATS2 DVL1 DVL3	2.82e-06	13	76	3	20412773
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	USP34 CCDC88A RGPD8 DVL1 DVL3 GOLGA5 CUX1 PCNT	3.76e-06	418	76	8	34709266
Pubmed	TLR3 preconditioning enhances the therapeutic efficacy of umbilical cord mesenchymal stem cells in TNBS-induced colitis via the TLR3-Jagged-1-Notch-1 pathway.	TLR3 NOTCH1	4.71e-06	2	76	2	27649928
Pubmed	cDNA cloning of a human dishevelled DVL-3 gene, mapping to 3q27, and expression in human breast and colon carcinomas.	DVL1 DVL3	4.71e-06	2	76	2	9344861
Pubmed	A genome-wide association study reveals 2 new susceptibility loci for atopic dermatitis.	XIRP2 DMRTA1	4.71e-06	2	76	2	25865352
Pubmed	Human homologue sequences to the Drosophila dishevelled segment-polarity gene are deleted in the DiGeorge syndrome.	DVL1P1 DVL1	4.71e-06	2	76	2	8644734
Pubmed	Expression of dishevelled gene in Hirschsprung's disease.	DVL1 DVL3	4.71e-06	2	76	2	24040443
Pubmed	Notch signaling indirectly promotes chondrocyte hypertrophy via regulation of BMP signaling and cell cycle arrest.	BMP2 NOTCH1	4.71e-06	2	76	2	27146698
Pubmed	Notch 1 impairs osteoblastic cell differentiation.	BMP2 NOTCH1	4.71e-06	2	76	2	12960086
Pubmed	Rootletin interacts with C-Nap1 and may function as a physical linker between the pair of centrioles/basal bodies in cells.	CEP250 CROCC	4.71e-06	2	76	2	16339073
Pubmed	C-NAP1 and rootletin restrain DNA damage-induced centriole splitting and facilitate ciliogenesis.	CEP250 CROCC	4.71e-06	2	76	2	23070519
Pubmed	DVL1 and DVL3 require nuclear localisation to regulate proliferation in human myoblasts.	DVL1 DVL3	4.71e-06	2	76	2	35589804
Pubmed	Myo1b Promotes Premature Endothelial Senescence and Dysfunction via Suppressing Autophagy: Implications for Vascular Aging.	LRRK2 MYO1B	4.71e-06	2	76	2	36654782
Pubmed	Ubiquitin-specific protease USP34 controls osteogenic differentiation and bone formation by regulating BMP2 signaling.	USP34 BMP2	4.71e-06	2	76	2	30181118
Pubmed	DVL3 Alleles Resulting in a -1 Frameshift of the Last Exon Mediate Autosomal-Dominant Robinow Syndrome.	DVL1 DVL3	4.71e-06	2	76	2	26924530
Pubmed	GSK-3 signaling in developing cortical neurons is essential for radial migration and dendritic orientation.	DVL1 DVL3 CUX1	7.99e-06	18	76	3	25073924
Pubmed	Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.	TDRD3 IGF2BP2 MIA3 DVL1 DVL3 RBM39	9.04e-06	220	76	6	24550385
Pubmed	The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly.	CEP250 CROCC PCNT	9.47e-06	19	76	3	24421332
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	KIF21B FLII XIRP2 KIF19 NUMA1 EXOC3 HERC1 RBM39	1.32e-05	497	76	8	36774506
Pubmed	Differential mediation of the Wnt canonical pathway by mammalian Dishevelleds-1, -2, and -3.	DVL1 DVL3	1.41e-05	3	76	2	18093802
Pubmed	DVL mutations identified from human neural tube defects and Dandy-Walker malformation obstruct the Wnt signaling pathway.	DVL1 DVL3	1.41e-05	3	76	2	32900645
Pubmed	Essential role of the Dishevelled DEP domain in a Wnt-dependent human-cell-based complementation assay.	DVL1 DVL3	1.41e-05	3	76	2	27744318
Pubmed	Cytosolic TMEM88 promotes invasion and metastasis in lung cancer cells by binding DVLS.	DVL1 DVL3	1.41e-05	3	76	2	26359454
Pubmed	NOTCH1 signaling regulates the BMP2/DLX-3 directed osteogenic differentiation of dental follicle cells.	BMP2 NOTCH1	1.41e-05	3	76	2	24321094
Pubmed	Notch signaling pathway enhances bone morphogenetic protein 2 (BMP2) responsiveness of Msx2 gene to induce osteogenic differentiation and mineralization of vascular smooth muscle cells.	BMP2 NOTCH1	1.41e-05	3	76	2	21471203
Pubmed	Purified Wnt-5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation.	DVL1 DVL3	1.41e-05	3	76	2	15748172
Pubmed	Promotion of dentin regeneration via CCN3 modulation on Notch and BMP signaling pathways.	BMP2 NOTCH1	1.41e-05	3	76	2	24406215
Pubmed	Dishevelled proteins are significantly upregulated in chronic lymphocytic leukaemia.	DVL1 DVL3	1.41e-05	3	76	2	27086035
Pubmed	Dishevelled-3 C-terminal His single amino acid repeats are obligate for Wnt5a activation of non-canonical signaling.	DVL1 DVL3	1.41e-05	3	76	2	21092292
Pubmed	Genomic organization of mouse Dishevelled genes.	DVL1 DVL3	1.41e-05	3	76	2	8973355
Pubmed	Dishevelled family proteins are expressed in non-small cell lung cancer and function differentially on tumor progression.	DVL1 DVL3	1.41e-05	3	76	2	18692936
Pubmed	Dishevelled proteins are associated with olfactory sensory neuron presynaptic terminals.	DVL1 DVL3	1.41e-05	3	76	2	23437169
Pubmed	Autosomal Dominant Robinow Syndrome	DVL1 DVL3	1.41e-05	3	76	2	25577943
Pubmed	Charting the landscape of tandem BRCT domain-mediated protein interactions.	DNHD1 FLII CCDC88A IPO9 NUMA1 PALLD RBM39 CUX1 PCNT	1.56e-05	670	76	9	22990118
Pubmed	Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.	FLII TDRD3 MIA3 CCDC88A PEX5 GOLGA5	1.91e-05	251	76	6	29778605
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	MIA3 CCDC88A LATS2 DVL1 DVL3 GOLGA5	2.48e-05	263	76	6	34702444
Pubmed	Huwe1-mediated ubiquitylation of dishevelled defines a negative feedback loop in the Wnt signaling pathway.	DVL1 DVL3	2.82e-05	4	76	2	24643799
Pubmed	Inhibition of the Wnt/beta-catenin pathway by the WWOX tumor suppressor protein.	DVL1 DVL3	2.82e-05	4	76	2	19465938
Pubmed	DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling.	DVL1 DVL3	2.82e-05	4	76	2	25557784
Pubmed	Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein.	DVL1 DVL3	2.82e-05	4	76	2	11113207
Pubmed	Tooth morphogenesis and the differentiation of ameloblasts.	BMP2 NOTCH1	2.82e-05	4	76	2	9189614
Pubmed	Golgin tethers define subpopulations of COPI vesicles.	GOLGA5 CUX1	2.82e-05	4	76	2	15718469
Pubmed	Crosstalk between Toll-like receptor 3 and Notch signaling contributes to CD14+ monocytes activity in enterovirus 71 infected hand, foot, and mouth disease.	TLR3 NOTCH1	2.82e-05	4	76	2	29702280
Pubmed	Non-canonical Wnt signaling induces ubiquitination and degradation of Syndecan4.	DVL1P1 DVL1	2.82e-05	4	76	2	20639201
Pubmed	Loss of Dishevelleds disrupts planar polarity in ependymal motile cilia and results in hydrocephalus.	DVL1 DVL3	2.82e-05	4	76	2	25043421
Pubmed	Phosphorylation of Dishevelled by protein kinase RIPK4 regulates Wnt signaling.	DVL1 DVL3	2.82e-05	4	76	2	23371553
Pubmed	Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation.	DVL1 DVL3	2.82e-05	4	76	2	18772438
Pubmed	Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration.	FLII TIAM1	2.82e-05	4	76	2	26887924
Pubmed	Activation of p53 by Dishevelled independent of Wnt or planar polarity pathways.	DVL1 DVL3	2.82e-05	4	76	2	17593335
Pubmed	Identification of a novel Ran binding protein 2 related gene (RANBP2L1) and detection of a gene cluster on human chromosome 2q11-q12.	RGPD8 RGPD5	2.82e-05	4	76	2	9480752
Pubmed	Clinical and molecular characterization of four patients with Robinow syndrome from different families.	DVL1 DVL3	2.82e-05	4	76	2	33496066
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	USP34 TDRD3 MIA3 BRIP1 CCDC88A RGPD8 PEX5 GOLGA5 CROCC	3.16e-05	733	76	9	34672954
Pubmed	The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.	RGPD8 NUMA1 DVL3 UHRF2	3.90e-05	86	76	4	37253089
Pubmed	Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.	USP13 BRIP1 IPO9 RNF20	4.08e-05	87	76	4	17148452
Pubmed	Functional proteomics mapping of a human signaling pathway.	USP13 IRF2BP1 CLPB CEP250 DVL3 CCDC181 HERC1 UHRF2	4.53e-05	591	76	8	15231748
Pubmed	Independent mutations in mouse Vangl2 that cause neural tube defects in looptail mice impair interaction with members of the Dishevelled family.	DVL1 DVL3	4.69e-05	5	76	2	15456783
Pubmed	The E3 ubiquitin ligase ITCH negatively regulates canonical Wnt signaling by targeting dishevelled protein.	DVL1 DVL3	4.69e-05	5	76	2	22826439
Pubmed	DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability.	DVL1 DVL3	4.69e-05	5	76	2	10330181
Pubmed	CCDC102B functions in centrosome linker assembly and centrosome cohesion.	CEP250 CROCC	4.69e-05	5	76	2	30404835
Pubmed	A novel Wnt5a-Frizzled4 signaling pathway mediates activity-independent dendrite morphogenesis via the distal PDZ motif of Frizzled 4.	DVL1 DVL3	4.69e-05	5	76	2	25424568
Pubmed	Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl.	DVL1 DVL3	4.69e-05	5	76	2	20227366
Pubmed	Centlein mediates an interaction between C-Nap1 and Cep68 to maintain centrosome cohesion.	CEP250 CROCC	4.69e-05	5	76	2	24554434
Pubmed	The sirtuins promote Dishevelled-1 scaffolding of TIAM1, Rac activation and cell migration.	TIAM1 DVL1	4.69e-05	5	76	2	24362520
Pubmed	A dishevelled-1/Smad1 interaction couples WNT and bone morphogenetic protein signaling pathways in uncommitted bone marrow stromal cells.	BMP2 DVL1	4.69e-05	5	76	2	16621789
Pubmed	FBW7 suppresses ovarian cancer development by targeting the N6-methyladenosine binding protein YTHDF2.	FLII IGF2BP2 IPO9 NUMA1 EXOC3 MYO1B UHRF2 RBM39	5.10e-05	601	76	8	33658012
Pubmed	Identification of human protein interaction domains using an ORFeome-based yeast two-hybrid fragment library.	NUMA1 RNF20 DVL3	5.22e-05	33	76	3	23718855
Pubmed	Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy.	KIF21B DNHD1 CROCC CUX1 PCNT	5.78e-05	187	76	5	26460568
Pubmed	A germline-specific class of small RNAs binds mammalian Piwi proteins.	FSIP2 CCDC88A NUMA1 PEX5 TDRD10 ANKRD12 CUX1	5.87e-05	450	76	7	16751776
Pubmed	Dual regulation of planar polarization by secreted Wnts and Vangl2 in the developing mouse cochlea.	DVL1 DVL3 PCNT	6.24e-05	35	76	3	32907846
Pubmed	Genomic analysis of mouse retinal development.	LRIG2 IPO9 CLPB MKNK2 RP1L1 RNF20 DVL1 CROCC RBM39 NOTCH1	6.65e-05	1006	76	10	15226823
Pubmed	Targeting E3 Ubiquitin Ligase WWP1 Prevents Cardiac Hypertrophy Through Destabilizing DVL2 via Inhibition of K27-Linked Ubiquitination.	DVL1 DVL3	7.03e-05	6	76	2	34139860
Pubmed	Nuclear factor of activated T cells (NFAT) proteins repress canonical Wnt signaling via its interaction with Dishevelled (Dvl) protein and participate in regulating neural progenitor cell proliferation and differentiation.	DVL1 DVL3	7.03e-05	6	76	2	21880741
Pubmed	Deletion of the Dishevelled family of genes disrupts anterior-posterior axis specification and selectively prevents mesoderm differentiation.	DVL1 DVL3	7.03e-05	6	76	2	32579954
Pubmed	Cep44 functions in centrosome cohesion by stabilizing rootletin.	CEP250 CROCC	7.03e-05	6	76	2	31974111
Pubmed	SIRT1 regulates Dishevelled proteins and promotes transient and constitutive Wnt signaling.	DVL1 DVL3	7.03e-05	6	76	2	20439735
Pubmed	Identification of Human Neuronal Protein Complexes Reveals Biochemical Activities and Convergent Mechanisms of Action in Autism Spectrum Disorders.	CEP250 CROCC CUX1 PCNT	7.32e-05	101	76	4	26949739
Pubmed	Centrosome-related genes, genetic variation, and risk of breast cancer.	LATS2 CEP250 NUMA1 PCNT	7.61e-05	102	76	4	20508983
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	USP34 MIA3 IPO9 MYO1B ANKRD12 RBM39	7.62e-05	322	76	6	26514267
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	FLII IGF2BP2 IRF2BP1 NUMA1 PEX5 EXOC3 MYO1B RBM39 ABCB1 PCNT	7.70e-05	1024	76	10	24711643
Pubmed	The CRL4DCAF6 E3 ligase ubiquitinates CtBP1/2 to induce apoptotic signalling and promote intervertebral disc degeneration.	MIA3 IPO9 DVL1 DVL3 ABCB1	7.75e-05	199	76	5	36688959
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	LRIG2 FAM184B MIA3 CCDC88A TIAM1 CLPB MRPL10 EXOC3 GOLGA5 QRSL1 CUX1 PCNT	8.78e-05	1487	76	12	33957083
Pubmed	An Interaction Landscape of Ubiquitin Signaling.	USP13 CLPB UBXN6 SNX27 HERC1 PALLD PCNT	8.90e-05	481	76	7	28190767
Pubmed	Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.	KIF21B MIA3 IPO9 CLPB CEP250 NUMA1 RNF20 RBM39 PCNT	9.58e-05	847	76	9	35235311
Pubmed	Interactomes of Glycogen Synthase Kinase-3 Isoforms.	TDRD3 MIA3 CCDC88A PEX5 PALLD	9.76e-05	209	76	5	36779422
Pubmed	Complex genomic rearrangements lead to novel primate gene function.	RGPD8 RGPD5	9.83e-05	7	76	2	15710750
Pubmed	Dishevelled proteins regulate cell adhesion in mouse blastocyst and serve to monitor changes in Wnt signaling.	DVL1 DVL3	9.83e-05	7	76	2	17005174
Pubmed	Adam10 is essential for early embryonic cardiovascular development.	BMP2 NOTCH1	9.83e-05	7	76	2	20803506
Pubmed	The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins.	GOLGA5 CUX1	9.83e-05	7	76	2	15004235
Interaction	CTNNB1 interactions	FLII USP13 CCDC88A LATS2 CEP250 LRRK2 NUMA1 DVL1 DVL3 MYO1B CROCC UHRF2 RBM39 NOTCH1 CUX1	3.80e-06	1009	75	15	int:CTNNB1
Interaction	LATS1 interactions	TDRD3 MYH8 MIA3 CCDC88A LATS2 XIRP2 LRRK2 DVL1 MYO1B PCNT	5.19e-06	440	75	10	int:LATS1
Interaction	NUP62 interactions	CCDC88A RGPD8 CEP250 NUMA1 RNF20 CUX1 PCNT RGPD5	7.88e-06	273	75	8	int:NUP62
Interaction	DVL3 interactions	CCDC88A LRRK2 NUMA1 DVL1 DVL3 SNX27 UHRF2 RBM39	9.47e-06	280	75	8	int:DVL3
Interaction	NUP43 interactions	FSIP2 USP34 BRIP1 CCDC88A RGPD8 CEP250 DVL1 SNX27 TIMELESS RBM39 RGPD5	1.89e-05	625	75	11	int:NUP43
Interaction	CFAP184 interactions	CCDC88A RNF20 PEX5 SMG5 PCNT RGPD5	3.13e-05	162	75	6	int:CFAP184
Interaction	ABTB2 interactions	MYH8 CCDC88A TIAM1 SNX27 NOTCH1	3.74e-05	101	75	5	int:ABTB2
Interaction	KXD1 interactions	CEP250 NUMA1 RNF20 PEX5 EXOC3 CUX1	4.10e-05	170	75	6	int:KXD1
Interaction	PMS1 interactions	USP13 BRIP1 IPO9 UBXN6 RNF20	4.51e-05	105	75	5	int:PMS1
Interaction	HDAC1 interactions	FLII MYH8 LATS2 CEP250 RNF20 DVL1 DVL3 GOLGA5 CROCC UHRF2 RBM39 NOTCH1 CUX1 PCNT	5.11e-05	1108	75	14	int:HDAC1
Interaction	CPAP interactions	IPO9 LATS2 DVL3 SNX27 PALLD PCNT	6.00e-05	182	75	6	int:CPAP
Interaction	C1orf87 interactions	LRRK2 HERC1 PCNT	6.27e-05	21	75	3	int:C1orf87
Interaction	MLF1 interactions	TDRD3 CCDC88A IRF2BP1 HERC1 RGPD5	6.40e-05	113	75	5	int:MLF1
Interaction	FAM120C interactions	TDRD3 IGF2BP2 MIA3 DVL3 SMG5 RBM39	7.84e-05	191	75	6	int:FAM120C
Interaction	WHAMMP3 interactions	CEP250 RNF20 HERC1 CROCC PCNT	8.19e-05	119	75	5	int:WHAMMP3
Interaction	RCOR1 interactions	USP34 FLII CCDC88A NUMA1 DVL1 DVL3 GOLGA5 UHRF2 CUX1	8.88e-05	494	75	9	int:RCOR1
Interaction	SSX2IP interactions	TDRD3 LATS2 CEP250 NUMA1 DVL1 DVL3 PCNT	9.79e-05	288	75	7	int:SSX2IP
Interaction	CELF1 interactions	TDRD3 IGF2BP2 CCDC88A MKNK2 SMG5 RBM39 NOTCH1	9.79e-05	288	75	7	int:CELF1
Interaction	HERC2 interactions	FLII CCDC88A CEP250 LRRK2 MRPL10 HERC1 MAPKAPK5 RBM39 CUX1	1.02e-04	503	75	9	int:HERC2
Interaction	FUBP3 interactions	KIF21B TDRD3 IGF2BP2 CCDC88A LATS2 SMG5 RBM39	1.19e-04	297	75	7	int:FUBP3
Interaction	RGPD2 interactions	RGPD8 EXOC3 RGPD5	1.36e-04	27	75	3	int:RGPD2
Interaction	UNK interactions	USP34 TDRD3 IGF2BP2 IPO9 DVL3 SMG5 HERC1 CYRIB	1.36e-04	408	75	8	int:UNK
Interaction	TCP10L interactions	LRRK2 NUMA1 RNF20 PCNT	1.42e-04	71	75	4	int:TCP10L
Interaction	MAP2K6 interactions	TLR3 LRRK2 EXOC3 NCF4	1.67e-04	74	75	4	int:MAP2K6
Interaction	FBXO22 interactions	KIF21B FLII LATS2 XIRP2 KIF19 NUMA1 EXOC3 HERC1 RBM39	1.74e-04	540	75	9	int:FBXO22
Interaction	EPB41L4A interactions	CCDC88A DVL1 DVL3 MYO1B MAPKAPK5	1.76e-04	140	75	5	int:EPB41L4A
Interaction	LINC02694 interactions	USP34 CLPB	2.03e-04	6	75	2	int:LINC02694
Interaction	UBC interactions	USP34 USP13 CLPB UBXN6 SNX27 HERC1 PALLD PCNT	2.49e-04	446	75	8	int:UBC
Interaction	DVL1 interactions	USP13 LRRK2 NUMA1 DVL1 DVL3	2.50e-04	151	75	5	int:DVL1
Interaction	HNRNPA1L2 interactions	MIA3 NUMA1 EXOC3 ANKRD12 RBM39	2.50e-04	151	75	5	int:HNRNPA1L2
Interaction	SMG5 interactions	FLII TDRD3 IGF2BP2 SMG5	2.73e-04	84	75	4	int:SMG5
GeneFamily	Dishevelled segment polarity proteins\|PDZ domain containing	DVL1 DVL3	4.66e-05	4	51	2	505
GeneFamily	Tudor domain containing	TDRD3 TDRD10 UHRF2	1.54e-04	37	51	3	780
GeneFamily	Mitogen-activated protein kinase-activated protein kinases	MKNK2 MAPKAPK5	4.22e-04	11	51	2	1156
GeneFamily	PDZ domain containing	TIAM1 DVL1 DVL3 SNX27	8.83e-04	152	51	4	1220
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	RGPD8 PEX5 RGPD5	4.18e-03	115	51	3	769
Coexpression	BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_UP	LRIG2 BMP2 SP2 MKNK2 ANKRD12 GOLGA5 PALLD RBM39 NOTCH1 CUX1 RGPD5	2.12e-05	822	75	11	M6782
Coexpression	HALLMARK_MITOTIC_SPINDLE	CCDC88A TIAM1 CEP250 NUMA1 PALLD PCNT	2.31e-05	199	75	6	M5893
Coexpression	GSE28237_EARLY_VS_LATE_GC_BCELL_DN	FLII MYH8 MIA3 SVBP CROCC MAPKAPK5	2.38e-05	200	75	6	M4894
Drug	topiramate; Down 200; 3uM; MCF7; HT_HG-U133A_EA	METTL5 IPO9 IRF2BP1 TIAM1 CEP250 SMG5 CYRIB	3.48e-06	196	74	7	915_DN
Disease	neurodegenerative disease (implicated_via_orthology)	DVL1P1 LATS2 LRRK2 DVL1 DVL3	2.87e-05	145	72	5	DOID:1289 (implicated_via_orthology)
Disease	Robinow Syndrome	DVL1 DVL3	3.51e-05	4	72	2	C0265205
Disease	Robinow Syndrome, Autosomal Dominant	DVL1 DVL3	3.51e-05	4	72	2	C4551476
Disease	propionic acid measurement	IGF2BP2 PALLD	3.51e-05	4	72	2	EFO_0010525
Disease	DiGeorge syndrome (is_implicated_in)	DVL1P1 DVL1	5.84e-05	5	72	2	DOID:11198 (is_implicated_in)
Disease	obsolete_red blood cell distribution width	C9orf153 IGF2BP2 BRIP1 IRF2BP1 RP1L1 DMRTA1 ANKRD12 SMG5 HERC1 CYRIB NOTCH1 ABCB1	9.46e-05	1347	72	12	EFO_0005192
Disease	Colorectal Carcinoma	BMP2 TIAM1 GUCY2C MYO1B DMRTA1 UHRF2 CUX1 ABCB1	3.09e-04	702	72	8	C0009402
Disease	mean corpuscular hemoglobin concentration	BRIP1 IRF2BP1 RP1L1 RNF20 DVL3 MYO1B DMRTA1 ANKRD12 SMG5 CYRIB	3.39e-04	1105	72	10	EFO_0004528
Disease	metabolite measurement, body weight gain	KIF19 PEX5	3.81e-04	12	72	2	EFO_0004566, EFO_0004725
Disease	Microcephaly	CCDC88A METTL5 TSEN2	5.97e-04	67	72	3	C0025958
Disease	Down syndrome (is_marker_for)	BRIP1 PCNT	1.31e-03	22	72	2	DOID:14250 (is_marker_for)
Disease	gestational diabetes	IGF2BP2 DMRTA1	1.44e-03	23	72	2	EFO_0004593
Disease	post-traumatic stress disorder	BMP2 IPO9 DMRTA1 CYRIB	1.52e-03	202	72	4	EFO_0001358
Disease	Cerebral Astrocytoma	LATS2 NOTCH1	1.70e-03	25	72	2	C0750935
Disease	Intracranial Astrocytoma	LATS2 NOTCH1	1.70e-03	25	72	2	C0750936
Disease	Pilocytic Astrocytoma	LATS2 NOTCH1	1.70e-03	25	72	2	C0334583
Disease	Astrocytoma	LATS2 NOTCH1	1.70e-03	25	72	2	C0004114
Disease	Juvenile Pilocytic Astrocytoma	LATS2 NOTCH1	1.70e-03	25	72	2	C0280783
Disease	Diffuse Astrocytoma	LATS2 NOTCH1	1.70e-03	25	72	2	C0280785
Disease	Grade I Astrocytoma	LATS2 NOTCH1	1.70e-03	25	72	2	C1704230
Disease	Subependymal Giant Cell Astrocytoma	LATS2 NOTCH1	1.70e-03	25	72	2	C0205768
Disease	Mixed oligoastrocytoma	LATS2 NOTCH1	1.70e-03	25	72	2	C0547065
Disease	Childhood Cerebral Astrocytoma	LATS2 NOTCH1	1.70e-03	25	72	2	C0338070
Disease	Gemistocytic astrocytoma	LATS2 NOTCH1	1.84e-03	26	72	2	C0334581
Disease	Protoplasmic astrocytoma	LATS2 NOTCH1	1.84e-03	26	72	2	C0334580
Disease	Fibrillary Astrocytoma	LATS2 NOTCH1	1.84e-03	26	72	2	C0334582
Disease	serum non-albumin protein measurement	MIA3 NUMA1 TDRD10 DMRTA1 TSEN2	1.91e-03	361	72	5	EFO_0004568
Disease	Anaplastic astrocytoma	LATS2 NOTCH1	1.98e-03	27	72	2	C0334579
Disease	Weight Gain	MYO1B TSEN2 PALLD	2.01e-03	102	72	3	C0043094

Protein segments in the cluster

Peptide	Gene	Start	Entry
EAVQELNSFLAQENM	RNF20	216	Q5VTR2
VFENQANMLERAVND	CCDC7	281	Q96M83
QQARREMEAQQAALD	CUX1	711	P39880
DALQAQREAFLEQMS	DNHD1	3211	Q96M86
MRQQHEAAALNAVQR	ANKRD12	2006	Q6UB98
NFENMSNDDAVRVLR	DVL3	306	Q92997
QVFREQMQDALGNNS	BMP2	151	P12643
LRVENMEDVFQNLTQ	CAPN14	651	A8MX76
QASQAEKNRAAAMAN	RBM39	226	Q14498
DRNSLLNMICQQVEA	RGPD5	806	Q99666
DRNSLLNMICQQVEA	RGPD8	806	O14715
VENQQRLQAEFSDMI	GUCY2C	1016	P25092
QEITSRFVMNQLAEN	LRRC69	251	Q6ZNQ3
NAGNLEDLMSNITNR	ABCB1	81	P08183
RLLEASADANIQDNM	NOTCH1	1946	P46531
LTNLEEFMAANNNLE	FLII	316	Q13045
QAHAEQLANMRIQDL	MAPKAPK5	331	Q8IW41
AAEVNRQMLQELVNA	LATS2	96	Q9NRM7
VFQLERLEQQMNSAS	GOLGA5	616	Q8TBA6
QAMVADFSSAQAQLQ	FAM184B	866	Q9ULE4
QASIIAMEQQQLRAE	HERC1	1621	Q15751
NFNDIASNLVSDIRM	FSIP2	4501	Q5CZC0
LQQENMNLLSDARSA	CCDC88A	291	Q3V6T2
NEMEIQLNHANRLAA	MYH8	1626	P13535
AAEAIAMNRQLAQHD	MKNK2	396	Q9HBH9
DLLAEMQQIEQSNFR	PEX5	86	P50542
MQEAIDAINNRVTQL	KIF21B	441	O75037
MAVAQQLRAESDFEQ	NCF4	1	Q15080
RNIMLNNDELEFEQA	LRRK2	1866	Q5S007
DLENAQFSEIQMERQ	METTL7B	211	Q6UX53
MEAQERSFQENIAQL	GBP7	516	Q8N8V2
REAFENDMLAVNQQA	IGF2BP2	346	Q9Y6M1
LREAEMRQLQDQQAA	PCNT	791	O95613
QEDDNIMRSLQLFQN	KCNIP1	211	Q9NZI2
RFARDELDSMVNNNI	BRIP1	416	Q9BX63
QLREQLASAFQEQMD	KIF19	421	Q2TAC6
RAALQMQFNAAERET	PALLD	596	Q8WX93
NRNAEEFELTNIDMV	METTL5	91	Q9NRN9
QNESSRNAQFLDMVA	ACP2	176	P11117
DMNSRQENRDPQQAF	CCDC181	401	Q5TID7
NAMLREQLDQAGSAN	CROCC	236	Q5TZA2
RSAQDDIFTQAVNMA	QRSL1	441	Q9H0R6
MAAQVALRRQQAQEE	DMRTA1	136	Q5VZB9
NEAQEVLARNLNVMS	C9orf153	51	Q5TBE3
SRMEAAEQARNALQV	CEP250	631	Q9BV73
IINELSNVMEANAAR	IPO9	921	Q96P70
AALLEAARANNMQEV	CLPB	136	Q9H078
ENEVNNELANRMSLF	CYRIB	176	Q9NUQ9
LLQVNDVNFENMSND	DVL1	301	O14640
LLQVNDVNFENMSND	DVL1P1	301	P54792
MFEQNLQVAAQISED	EXOC3	431	O60645
QQRNADCLAELNEAM	IRF2BP1	201	Q8IU81
AANNTQLQARVEMLE	NUMA1	426	Q14980
RAEMINNNVIVRNAE	TSEN2	41	Q8NCE0
ALNRVMTELEQQQFD	SVBP	41	Q8N300
ASRQALMDNGNNLEA	TDRD3	211	Q9H7E2
QQAQAQFRMAQEEAR	SMG5	806	Q9UPR3
NRDLGMNENNIFEEA	MIA3	1001	Q5JRA6
QNMQALFSTLAQAEE	TDRD10	221	Q5VZ19
LQNMEAEQQRRAQEA	IQANK1	286	A8MXQ7
SRGLENANSEIQMLN	CLEC4F	216	Q8N1N0
NRTVQMAENFVNDPE	XIRP2	3141	A4UGR9
ADQTLTNMNRALALN	UHRF2	526	Q96PU4
NEEAMENEQFQQLLR	TIMELESS	1051	Q9UNS1
EAQMAAAAALARLEQ	UBXN6	51	Q9BZV1
LDLSNNNIANINDDM	TLR3	511	O15455
LEINNRAADALNSSM	TIAM1	896	Q13009
QDNRMIAVCQNVALS	MRPL10	91	Q7Z7H8
MAAELQQDVAQRLQD	RP1L1	1556	Q8IWN7
AAQLAAAAQAMQTIN	SP2	426	Q02086
ENIFQMARSQQRDVA	SNX27	526	Q96L92
NVNNRMASLAIAEDR	TRAV26-2	71	A0A0B4J265
ANAVADMLRENRSLQ	TMOD4	241	Q9NZQ9
DQELRQSAARNMADL	USP34	281	Q70CQ2
FVIEMENNANANIIS	USP13	776	Q92995
DLNNNAIMSIQENAF	LRIG2	416	O94898
DDAANFRTVRNAMQI	MYO1B	246	O43795