Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
DomainLCE

LCE3D LCE3E

5.38e-0417382PF14672
DomainLCE

LCE3D LCE3E

5.38e-0417382IPR028205
Pubmed

Nuclear Receptor Subfamily 1 Group D Member 1 Regulates Circadian Activity of NLRP3 Inflammasome to Reduce the Severity of Fulminant Hepatitis in Mice.

NR1D1 NLRP3

1.23e-06239229277561
Pubmed

Cutting edge: nitric oxide inhibits the NLRP3 inflammasome.

NOS2 NLRP3

3.67e-06339223100513
Pubmed

REV-ERBα integrates colon clock with experimental colitis through regulation of NF-κB/NLRP3 axis.

NR1D1 NLRP3

3.67e-06339230315268
Pubmed

Potential i-Nos/Arg-1 Switch with NLRP3 and Parasitic Load Down Regulation in Experimental Schistosoma mansoni Infection via Chloroquine Repurposing.

NOS2 NLRP3

3.67e-06339238498004
Pubmed

Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort.

PLAA ANK3

3.67e-06339220185149
Pubmed

Oscillating lncRNA Platr4 regulates NLRP3 inflammasome to ameliorate nonalcoholic steatohepatitis in mice.

NR1D1 NLRP3

7.34e-06439233391484
Pubmed

Molecular cloning and characterization of a novel mouse epidermal differentiation gene and its promoter.

LCE3D LCE3E

7.34e-06439211350120
Pubmed

Stabilin-1 localizes to endosomes and the trans-Golgi network in human macrophages and interacts with GGA adaptors.

GGA3 STAB1

7.34e-06439215345724
Pubmed

Brucella abortus nitric oxide metabolite regulates inflammasome activation and IL-1β secretion in murine macrophages.

NOS2 NLRP3

1.22e-05539230919410
Pubmed

Evaluation of IL-1 Blockade as an Adjunct to Linezolid Therapy for Tuberculosis in Mice and Macaques.

NOS2 NLRP3

1.22e-05539232477361
Pubmed

Liver repopulation and correction of metabolic liver disease by transplanted adult mouse pancreatic cells.

LCE3D LCE3E

1.22e-05539211159194
Pubmed

IFN-γ-dependent nitric oxide suppresses Brucella-induced arthritis by inhibition of inflammasome activation.

NOS2 NLRP3

2.56e-05739230748031
Pubmed

Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.

ZSWIM8 CPLANE1 ABCA13 ADAM28 PLK5 STAB1

3.25e-0555239610737800
Pubmed

Shedding of the tumor necrosis factor (TNF) receptor from the surface of hepatocytes during sepsis limits inflammation through cGMP signaling.

NOS2 NLRP3

3.42e-05839225628461
Pubmed

A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity.

FLG2 LCE3D LCE3E

4.71e-056239326644517
Pubmed

IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes.

NOS2 NLRP3

6.70e-051139227693356
Pubmed

Chronic Alcohol Exposure and the Circadian Clock Mutation Exert Tissue-Specific Effects on Gene Expression in Mouse Hippocampus, Liver, and Proximal Colon.

NR1D1 NOS2 NLRP3

8.00e-057439326332085
Pubmed

Neutrophil elastase causes tissue damage that decreases host tolerance to lung infection with burkholderia species.

NOS2 NLRP3

9.48e-051339225166912
Pubmed

Fate and plasticity of the epidermis in response to congenital activation of BRAF.

LCE3D LCE3E

9.48e-051339225202828
Pubmed

Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium.

NOS2 NLRP3

1.11e-041439226320999
Pubmed

Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.

GRM1 ANK3 CBFA2T2 CRTC2 GGA3

1.15e-0443039535044719
Pubmed

p63 regulates Satb1 to control tissue-specific chromatin remodeling during development of the epidermis.

LCE3D LCE3E

1.46e-041639221930775
Pubmed

Rodent Lce gene clusters; new nomenclature, gene organization, and divergence of human and rodent genes.

LCE3D LCE3E

1.46e-041639217410201
Pubmed

Late cornified envelope family in differentiating epithelia--response to calcium and ultraviolet irradiation.

LCE3D LCE3E

2.79e-042239215854049
Pubmed

Differentially expressed late constituents of the epidermal cornified envelope.

LCE3D LCE3E

3.05e-042339211698679
Pubmed

Keratin 1 maintains skin integrity and participates in an inflammatory network in skin through interleukin-18.

LCE3D LCE3E

3.62e-042539223132931
Pubmed

Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway.

NOS2 NLRP3

3.62e-042539235139355
Pubmed

Insulin/IGF-1 controls epidermal morphogenesis via regulation of FoxO-mediated p63 inhibition.

LCE3D LCE3E

3.62e-042539223906066
Pubmed

Pax9 is required for filiform papilla development and suppresses skin-specific differentiation of the mammalian tongue epithelium.

LCE3D LCE3E

3.91e-042639215454262
Pubmed

Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications.

NOS2 NLRP3

5.23e-043039228096401
Pubmed

Ets1 blocks terminal differentiation of keratinocytes and induces expression of matrix metalloproteases and innate immune mediators.

LCE3D LCE3E

5.58e-043139220930145
Pubmed

Dynamic spatiotemporal gene expression in embryonic mouse thalamus.

GRM1 NR1D1

9.77e-044139221192082
Cytoband1q21.3

FLG2 CRTC2 LCE3E

1.38e-041173931q21.3
CytobandEnsembl 112 genes in cytogenetic band chr1q21

FLG2 LCE3D CRTC2 LCE3E

3.81e-04404394chr1q21
Cytoband19p13.3

POLRMT ZFR2 PLK5

1.08e-0323739319p13.3
CytobandEnsembl 112 genes in cytogenetic band chr19p13

POLRMT ZFR2 FBN3 PLK5

4.58e-03797394chr19p13
CytobandEnsembl 112 genes in cytogenetic band chr8p21

CHRNA2 ADAM28

5.92e-03135392chr8p21
GeneFamilyLate cornified envelope proteins

LCE3D LCE3E

2.34e-0418232627
CoexpressionGSE17721_CTRL_VS_POLYIC_2H_BMDC_DN

CHADL PLAA CHRNA2 CRTC2 RNF111

1.15e-05200395M3712
ToppCellDendritic_Cells-Donor_02|World / lung cells shred on cell class, cell subclass, sample id

ADAM28 NLRP3 STAB1 SIGLEC10

1.33e-05166394fbeb74b98b58085de323f744b18d4a8f7b22d5d4
ToppCellcellseq2-Epithelial-Epithelial_Glandular-Goblet-Goblet|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ABCA13 NOS2 ADAM28 FYB2

1.49e-0517139425c1979e972c959e1ce4c57804f976f53a247ad7
ToppCellcellseq2-Epithelial-Epithelial_Glandular-Goblet|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ABCA13 NOS2 ADAM28 FYB2

1.49e-05171394fe27bf581c75ef33c2848878e51ed16b275a4c8e
ToppCellDendritic_Cells-IPF_01|World / lung cells shred on cell class, cell subclass, sample id

ADAM28 NLRP3 STAB1 SIGLEC10

1.75e-051783943a28103cf282cc3637d1875a3b4cd7ddf3207687
ToppCell367C-Myeloid-Dendritic-cDC1|367C / Donor, Lineage, Cell class and subclass (all cells)

ZNF467 ADAM28 NLRP3 SIGLEC10

1.91e-051823946f5228ac47f9ab46d165740cf2655b5ba217acbe
ToppCell5'-Adult-LymphNode-Hematopoietic-T_cells-ILC3|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SCART1 NLRP3 CRTC2 LPXN

2.03e-051853947d6954bb04368ec62b284ba6c3021a15fbdfdee6
ToppCellDendritic_Cells-Donor_01|World / lung cells shred on cell class, cell subclass, sample id

ADAM28 NLRP3 STAB1 SIGLEC10

2.08e-051863941d52912bd17e232cf39b2423a4d93585c164ba34
ToppCell5'-Adult-LargeIntestine-Hematopoietic-Myeloid-cDC2|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAM28 NLRP3 STAB1 SIGLEC10

2.08e-0518639469b107ad88b07e9aeef09d4e4dac99b0cb6b467e
ToppCellLAM-Myeloid-DC|LAM / Condition, Lineage and Cell class

ADAM28 NLRP3 STAB1 SIGLEC10

2.17e-05188394b4140110c2f7d25fd8a0d2749e33e02003ac4bf2
ToppCellcontrol-immature_Neutrophil|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ZNF467 ZFR2 GGA3 STAB1

2.21e-05189394bdfd120900ba58d5e54765f7b576e1f8cc2401bf
ToppCellCOVID-19-Epithelial_cells-Airway_goblet|COVID-19 / group, cell type (main and fine annotations)

ANK3 ABCA13 ADAM28 FYB2

2.26e-0519039451ca9ef4df3220487152fcf684147730637c7cc1
ToppCellMonocytes|World / lung cells shred on cell class, cell subclass, sample id

ZNF467 NLRP3 STAB1 SIGLEC10

2.40e-05193394d66d3927f8fbe1544b5cfa5ee91a7f4a0ef1e810
ToppCellNS-moderate-d_0-4|moderate / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ANK3 CPLANE1 ABCA13 FYB2

2.40e-05193394ea345d34440b25f65358a53dc72831998d1c3620
ToppCellDendritic_Cells|World / lung cells shred on cell class, cell subclass, sample id

ADAM28 NLRP3 STAB1 SIGLEC10

2.40e-051933947792eb6e247af2d7a8f80476f37dcd880922d625
ToppCellMonocytes-Donor_07|World / lung cells shred on cell class, cell subclass, sample id

ZNF467 NLRP3 STAB1 SIGLEC10

2.45e-05194394ed14fbb3b4622798f8e02dc91bbe464a6fed8310
ToppCell368C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)|Macrophage / Donor, Lineage, Cell class and subclass (all cells)

ZNF467 ADAM28 NLRP3 STAB1

2.45e-0519439458046894446cb250814252a23f60fdd59c114d77
ToppCell18-Airway-Immune-Hematopoietic,_Macrophage|Airway / Age, Tissue, Lineage and Cell class

NLRP3 LPXN STAB1 SIGLEC10

2.45e-051943949671fed8cd45ea8c7a411239aa5012c2a1edf264
ToppCellMNPs-Monocytes|MNPs / lung cells shred on cell class, cell subclass, sample id

ZNF467 NLRP3 STAB1 SIGLEC10

2.50e-0519539445e8d27287bdfd07d7e944ae5d3f44d05c33468f
ToppCell5'-Adult-SmallIntestine-Hematopoietic-Myeloid|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAM28 NLRP3 STAB1 SIGLEC10

2.50e-05195394f289a44010788853d7726d4b5aa75f3c62186c08
ToppCellcontrol-immature_Neutrophil|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

ZNF467 NLRP3 GGA3 STAB1

2.55e-05196394e34fd3e7a5b1c22a81fd3208e6d58bdb846d51c4
ToppCellILEUM-non-inflamed-(3)_moDC|non-inflamed / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

ADAM28 NLRP3 STAB1 SIGLEC10

2.55e-05196394e10f01172fd076d6892906853f9375d4c3058951
ToppCellTracheal-10x3prime_v2-Immune_Myeloid-Dendritic_cell-DC_2|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

ADAM28 NLRP3 LPXN SIGLEC10

2.60e-05197394febafd8f0f5bb9a09f496f240e6b6b5e9275669b
ToppCellBAL-Control-Myeloid-cDC-cDC-cDC_0|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ZNF467 ADAM28 NLRP3 STAB1

2.65e-051983947f7024b26337ae2bc7f57c3274a7dfdaaa64ab7c
ToppCellBAL-Control-Myeloid-cDC-cDC-cDC_0|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZNF467 ADAM28 NLRP3 STAB1

2.65e-0519839459214e34b077dffa989c48635fdef143f57f1320
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADAM28 NLRP3 STAB1 SIGLEC10

2.71e-0519939404adf46975aa4194ea40c7480f8a517def5d929c
ToppCellParenchymal-10x5prime-Epithelial-Epi_submucosal-gland|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LOXL4 FRK ABCA13

1.15e-0410839375d635fc5bb004418db2e1328c24d96b718f10b1
ToppCellParenchymal-10x5prime-Epithelial-Epi_submucosal-gland-SMG_Duct|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

LOXL4 FRK ABCA13

1.15e-041083939c7f3e25facfb54ef0be45044999bc36438bbea0
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-immature_mesenchymal_cell-Mesoderm_1_(HAND1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CHADL ABCA13 ADAM28

2.23e-041353935113bb1713f99d01103b9a99de5d80393081cf87
ToppCell3'-Broncho-tracheal-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes-|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ZNF467 NLRP3 STAB1

2.64e-041433937adc34d8ad11e57950a5a258ae9bf8f52259385a
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ZNF467 ADAM28 STAB1

2.98e-04149393a85a051e0d82430160967e72fa04b55f43e84513
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_4|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZNF467 ADAM28 STAB1

3.04e-041503937a381f5ae94eba5eb60dcbf83416b4eb18c279ea
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FRK ZFR2 FYB2

3.22e-041533930a4fbe46125b05ee235deb528855808c2bf33cba
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

FRK FBN3 FYB2

3.28e-04154393ce4b1e878cd88065fbfd2df18caf19703fec37d8
ToppCellCV-Healthy-3|Healthy / Virus stimulation, Condition and Cluster

ZSWIM8 ANK3 ZFR2

3.28e-0415439326bf81a86700db7e65c2384ffe94ed4253ea4047
ToppCellDendritic_Cells-Donor_03|World / lung cells shred on cell class, cell subclass, sample id

ZNF467 ADAM28 STAB1

3.28e-0415439365013f696da623d37f1e3447a294dfb3c31ae93b
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

ANK3 FYB2 SIGLEC10

3.47e-041573932c5295043611bac7dfa4aef2146681bce4a33a8f
ToppCellCD8+_Memory_T_cell-RSV-6|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

NR1D1 KHNYN SIGLEC10

3.54e-041583935ae737757a49fc96bde1e57e02066f9f65654ea1
ToppCelldroplet-Bladder-Unstain-18m-Hematologic-macrophage|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NLRP3 LPXN STAB1

3.54e-04158393e5e7b2d609973f1dd4fe7dc62bb69422268ea801
ToppCelldroplet-Bladder-nan-24m-Hematologic-macrophage|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NLRP3 LPXN STAB1

3.54e-041583934a9d4706876f6e86fc5d63ad6dc7df1b4a5cfd9e
ToppCellTCGA-Stomach-Primary_Tumor-Stomach_Adenocarcinoma-Stomach_Adenocarcinoma_-_Tubular-6|TCGA-Stomach / Sample_Type by Project: Shred V9

FRK SCART1 NR1D1

3.60e-04159393655c0749c238bd68cb797adb83e25a23b8a3cc9d
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_0|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ADAM28 NLRP3 STAB1

3.60e-04159393ded4e3626a62fb6334403b7213b467fb7e8131c3
ToppCelldroplet-Bladder-Unstain-18m-Hematologic|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NLRP3 LPXN STAB1

3.60e-04159393a80b4637a74bcc6f213d584aba2c727a983eedb3
ToppCelldroplet-Bladder-Unstain-18m-Hematologic-leukocyte|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NLRP3 LPXN STAB1

3.60e-0415939389b5e895e95cdd654edd471bde9b6887939b3503
ToppCellBAL-Mild-Myeloid-cDC-cDC-cDC_0|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ADAM28 NLRP3 STAB1

3.60e-041593932f6c60ddff2208a68146f9786143d9aefd528840
ToppCellCOVID-19_Moderate-MAIT|COVID-19_Moderate / disease group, cell group and cell class

SCART1 NR1D1 ZFR2

3.60e-041593936d08d670c34eb6bb8ad5dad3293b3107c006236d
ToppCelldroplet-Trachea-3m-Hematologic-myeloid-granulocyte-granulocyte_l1-4|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NR1D1 NLRP3 LPXN

3.67e-041603936329b0f02f9509086e563c2ed762a8ec693883b5
ToppCellfrontal_cortex-Non-neuronal-macrophage-Macrophage-Microglia_Siglech|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

NLRP3 LPXN STAB1

3.67e-04160393c3f2f362e5d0602bb997e8367b4c9a8fe88e4ea8
ToppCellLPS-antiTNF-Myeloid-Monocytes,_Macrophages-Neutrophils|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

TECPR2 NLRP3 LPXN

3.67e-041603935d8d97c3da5837ba5fe743d2f8438f5cb7cea64b
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ADGRA1 FBN3 FYB2

3.67e-041603931e210e526ea4d84fc58a798a26c0929bcb69fd89
ToppCellCOVID-19_Moderate-MAIT|World / disease group, cell group and cell class

SCART1 NR1D1 ZFR2

3.67e-04160393bf73c5fe87c1f243edec17d7a2c30fae5e2cfd6b
ToppCelldroplet-Bladder-nan-3m-Hematologic-macrophage|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NLRP3 LPXN STAB1

3.81e-041623930cee9ef405765f3f82d0cd7b8adc88f6e9fdbb5c
ToppCellfrontal_cortex-Non-neuronal-macrophage|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

NLRP3 LPXN STAB1

3.88e-04163393b89f586b444f90047c8ce407f53847fd1ee7cca3
ToppCellfrontal_cortex-Non-neuronal-macrophage-Macrophage|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

NLRP3 LPXN STAB1

3.88e-04163393cbe9b4c4b2e42e9f92a57ed66758af93434db5bb
ToppCellRSV-Healthy-6|RSV / Virus stimulation, Condition and Cluster

NR1D1 KHNYN SIGLEC10

3.95e-04164393ab312b8c2f828ea7331f2a340c4df81587a23b5c
ToppCellLPS-antiTNF-Epithelial_airway-Mes-Epi-like|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

STT3B GPRIN2 STAB1

3.95e-041643934307b002fb41ddfc7ab8a6bca66a60942c250052
ToppCellRSV-Healthy-6|Healthy / Virus stimulation, Condition and Cluster

NR1D1 KHNYN SIGLEC10

3.95e-041643931b9c5a6dc4e09b90f92e98b81a5ee620f8479cc7
ToppCellLPS-antiTNF-Epithelial_airway-Mes-Epi-like-Airway|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

STT3B GPRIN2 STAB1

3.95e-041643931d84aa5b925f502ee9c5fa39714490f613a58028
ToppCelldroplet-Limb_Muscle-nan-21m-Myeloid-macrophage|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NR1D1 NLRP3 LPXN

4.02e-04165393c2fc76feff58d77128f5a5318fed9c265574d760
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c09-SLC4A10|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

SCART1 NR1D1 KLHDC9

4.02e-041653935e7ee76f3dcddbd1b560bacd043f9001b0c18b5f
ToppCelldroplet-Limb_Muscle-nan-21m-Myeloid|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NR1D1 NLRP3 LPXN

4.02e-041653935f23173ec624ea7f893d22e326446f0e39e30b4e
ToppCelldroplet-Limb_Muscle-nan-21m-Myeloid-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NR1D1 NLRP3 LPXN

4.02e-041653931760ec2ac8913a2b33f46672a3f39ca7489966b8
ToppCellPCW_07-8.5-Hematologic_ErythroMegGranulo-Hem_Granulocytic-im_mast/basophil_(18)|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung

NLRP3 STAB1 SIGLEC10

4.09e-04166393f03f78cae6272c89618c0bda032ce45c4fc96baa
ToppCelldroplet-Lung-3m-Hematologic-myeloid-classical_monocyte-classical_monocyte_l2-17-52|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PLAA WRAP53 LPXN

4.09e-04166393de319c960b0cd90b294f677d1ea1b013a2ce2d53
ToppCellThalamus-Hematopoietic|Thalamus / BrainAtlas - Mouse McCarroll V32

NLRP3 LPXN STAB1

4.09e-0416639376d60ac7ac5d1eaf530f0c741d9c48e0bd58396b
ToppCellLPS-antiTNF-Epithelial_airway-Club_cells|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FRK ANK3 ADAM28

4.09e-041663931df4bdf7c773cbfa6c93d7a901f9cd3f3fe07a3d
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1-3_VIP_ACHE|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CHRNA2 FBN3 LCE3E

4.09e-041663932e8ac5e84b2231d7405121f1681623b25d1ec3ca
ToppCellLPS-antiTNF-Epithelial_airway-Club_cells-Airway|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

FRK ANK3 ADAM28

4.09e-041663939628522e7af8f8edca733588a364ab2454ac5ca5
ToppCell5'-Parenchyma_lung-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADAM28 FYB2 STT3B

4.09e-041663939e98e6070055bfc780becee52d77830e06b6d854
ToppCelldroplet-Bladder-BLADDER-1m-Hematologic-macrophage|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NLRP3 LPXN STAB1

4.16e-041673931a6a48180481f0c13c15bb93d6ff4eeb96a5b9a0
ToppCell(0)_Myeloid-(00)_Monocyte-(000)_CD14+_Monocyte|(00)_Monocyte / immune cells in Peripheral Blood (logTPM normalization)

ZNF467 NLRP3 STAB1

4.16e-041673937d9fd6a7a45c2aa0d5f2e3960ca4c97ee8836ba5
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NLRP3 PLK5 STAB1

4.23e-0416839326fce414439ccd204e3acb41f2b4f75072df5a26
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-M2_Macrophage|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

NLRP3 PLK5 STAB1

4.23e-0416839361a5435b27b01ff1a509ea463a6af220c5d2c9b3
ToppCellMonocytes-Donor_05|World / lung cells shred on cell class, cell subclass, sample id

ZNF467 STAB1 SIGLEC10

4.23e-041683939ea3c682ce4e98f1a3303f99b4c63c2cf8863abc
ToppCellDendritic_Cells-Donor_08|World / lung cells shred on cell class, cell subclass, sample id

ZNF467 STAB1 SIGLEC10

4.23e-0416839333618e5dbcee31f30afacacc9f6046782c100fb3
ToppCelldroplet-Bladder-BLADDER-1m-Hematologic-leukocyte|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NLRP3 LPXN STAB1

4.31e-04169393b46e446067c6425bd5b8ef7719aeecff5e861249
ToppCelldroplet-Bladder-BLADDER-1m-Hematologic|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NLRP3 LPXN STAB1

4.31e-041693935508b03fbf483fce7701d6c82c297ffda3b1ba05
ToppCellfacs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l44-58|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

APLP1 ANK3 ZFR2

4.31e-04169393d382a76d85875663502cc7dde2e3e0682605768e
ToppCellfacs-Trachea-24m-Hematologic-myeloid-tracheal_macrophage-macrophage_of_tracheal_l12|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NLRP3 LPXN STAB1

4.31e-041693938180aeda13c511260d0542a94156059d558848a7
ToppCellfacs-Trachea-3m-Hematologic-myeloid-tracheal_macrophage-macrophage_of_tracheal_l12|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NLRP3 LPXN STAB1

4.38e-04170393f524b73d65941ebef7671c46df4362a3f15d24fc
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LOXL4 FLG2 PLK5

4.38e-041703932d880223d01bde4bf777bd6f50b7d2768489075f
ToppCellBALF-PFMC-Severe-critical_progression_d12-22_no-steroids-Myeloid-Macrophage-macrophage,_alveolar-Macro_c3-EREG|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

NLRP3 LPXN STAB1

4.38e-041703939ac1ef57f14418a5dd2aa16861c3df698c28f5ed
ToppCelldroplet-Trachea-3m-Hematologic-myeloid-granulocyte-granulocyte_l12-45|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NLRP3 LPXN STAB1

4.38e-04170393e028e22ad051c2628248b212b5d28b891e0ee782
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Basal_resting-Basal_resting_L.0.0.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

LOXL4 FLG2 PLK5

4.38e-041703930cc20322cb3e3e7bbd4daad8785c99f80e355c16
ToppCellfacs-Trachea-18m-Hematologic-myeloid-tracheal_macrophage-macrophage_of_tracheal_l12|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

NLRP3 LPXN STAB1

4.46e-0417139326755e43d94e934106fc19ab929e4d34c17d6cba
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

LOXL4 ABCA13 ADAM28

4.53e-04172393afa36501d48b1456c511fa0d5d326ec05bdc380f
ToppCelldroplet-Lung-21m-Epithelial-airway_epithelial|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ANK3 KLHDC9 PLK5

4.61e-04173393a809be2630d2b91b53b82b5e2bb99e05524597c1
ToppCelldroplet-Limb_Muscle-MUSCLE-1m-Myeloid-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NLRP3 LPXN STAB1

4.61e-04173393a664dbd7fb55b1c4309fa5f9425bc83924dac545
ToppCell5'-GW_trimst-2-LargeIntestine-Hematopoietic-T_cells-ILCP|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SCART1 NR1D1 LPXN

4.69e-04174393c0204a0d0a979a489e8d30dc5396e99da14c119c
ToppCellBasal_cells-Cryobiopsy_01|World / lung cells shred on cell class, cell subclass, sample id

CHADL ABCA13 FYB2

4.69e-04174393a0060be3940043015dcc49a5157de5541aed24a1
ToppCellDendritic_Cells-IPF_02|World / lung cells shred on cell class, cell subclass, sample id

ADAM28 STAB1 SIGLEC10

4.77e-04175393584290a51f9975782a5ac8c6ad67c778d8323f8c
ToppCellCOVID-19-kidney-CD-IC-A|COVID-19 / Disease (COVID-19 only), tissue and cell type

FRK FBN3 FYB2

4.85e-0417639345028197364c64e93e3ffe86aff773d47a477d49
ToppCell3'-Parenchyma_lung-Immune_Myeloid-Myeloid_macrophage-elicited_macrophage-Monocyte-derived_macrophage-Monocyte-derived_macrophage_L.1.2.5.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

NLRP3 LPXN STAB1

4.85e-04176393b99e20e4dd8b3322c9d7a08d518ed4f8f356b3de
ToppCellMonocytes-Donor_01|World / lung cells shred on cell class, cell subclass, sample id

ZNF467 NLRP3 STAB1

4.85e-041763935b5f8655b0c6c56f98f70bce13e71f017d4b75a5
ToppCellE18.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KLHDC9 KHNYN STAB1

4.93e-041773938dfadd9852e0c256363471a7cfe6af120c8c51e0
ToppCellE18.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC-LEC_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KLHDC9 KHNYN STAB1

4.93e-04177393767b2af5f224d100b22bed32f86cec1cd17e8711
ToppCellE18.5-Endothelial-Endothelial_lymphatic-Lymphatic_EC-LEC|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KLHDC9 KHNYN STAB1

4.93e-041773935ef2527e9b41e62f1724cdabaad9d8979266bb7d
ToppCellE18.5-Endothelial-Endothelial_lymphatic|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

KLHDC9 KHNYN STAB1

4.93e-04177393ae1d2fdd4f67f50c906b27ea084de058c6908aa2
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Transitional_Principal-Intercalated_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ANK3 FBN3 FYB2

4.93e-04177393f35b04c3557ebbdeba37dec54c8f45880eafb422
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_GGH|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FLG2 CHRNA2 FBN3

4.93e-04177393a28ab55e4e2e6cc365d81da669e37f8c6f399dfb
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ADGRA1 FBN3 FYB2

5.01e-0417839351d2188406f04329311b2efd1108fc36617a860e
DrugMPTP-HCl

LOXL4 APLP1 GRM1 NOS2 CHRNA2

7.12e-06162385CID000001388
DrugGliquidone [33342-05-1]; Up 200; 7.6uM; HL60; HT_HG-U133A

PLAA ADAM28 CBFA2T2 GPRIN2 STAB1

1.70e-051943853126_UP
DrugMephenytoin [50-12-4]; Up 200; 18.4uM; PC3; HT_HG-U133A

ZSWIM8 PLAA GRM1 TECPR2 CHRNA2

1.79e-051963855801_UP
DrugHeptaminol hydrochloride [543-15-7]; Down 200; 22uM; MCF7; HT_HG-U133A

FRK APLP1 GRM1 NR1D1 CBFA2T2

1.79e-051963856015_DN
DrugRifampicin [13292-46-1]; Up 200; 4.8uM; HL60; HT_HG-U133A

WRAP53 NR1D1 CHRNA2 ADAM28 GGA3

1.88e-051983852487_UP
DrugMethiothepin maleate [19728-88-2]; Up 200; 8.4uM; PC3; HT_HG-U133A

GRM1 ZNF467 TECPR2 CHRNA2 GPRIN2

1.93e-051993856312_UP
Drugmalonate

GRM1 ANK3 NOS2 CHRNA2 ADAM28

2.44e-05209385CID000000867
DiseasePetit mal status

GRM1 ANK3 NOS2

8.23e-0567373C0270823
DiseaseGrand Mal Status Epilepticus

GRM1 ANK3 NOS2

8.23e-0567373C0311335
DiseaseStatus Epilepticus, Subclinical

GRM1 ANK3 NOS2

8.23e-0567373C0751522
DiseaseSimple Partial Status Epilepticus

GRM1 ANK3 NOS2

8.23e-0567373C0751524
DiseaseNon-Convulsive Status Epilepticus

GRM1 ANK3 NOS2

8.23e-0567373C0751523
DiseaseComplex Partial Status Epilepticus

GRM1 ANK3 NOS2

8.23e-0567373C0393734
DiseaseStatus Epilepticus

GRM1 ANK3 NOS2

8.60e-0568373C0038220
DiseaseAsbestosis

NOS2 NLRP3

1.38e-0414372C0003949
DiseasePulmonary Fibrosis - from Asbestos Exposure

NOS2 NLRP3

1.38e-0414372C2930617
DiseaseBipolar Disorder

ANK3 NR1D1 ABCA13 CHRNA2 STAB1

3.08e-04477375C0005586
DiseaseLung Neoplasms

ANK3 NOS2 CHRNA2 ADAM28

3.33e-04265374C0024121
DiseaseMalignant neoplasm of lung

ANK3 NOS2 CHRNA2 ADAM28

3.37e-04266374C0242379
DiseaseDepressive disorder

GRM1 NR1D1 NOS2 CHRNA2

4.61e-04289374C0011581
DiseaseInflammation

PLAA NOS2 NLRP3

5.44e-04127373C0021368
Diseaseaseptic loosening, revision of total knee arthroplasty

ANK3 NLRP3

1.28e-0342372EFO_0010725, EFO_0020972
DiseasePsoriasis

LCE3D NOS2

2.34e-0357372C0033860
DiseaseAlzheimer's disease (implicated_via_orthology)

APLP1 NOS2

2.34e-0357372DOID:10652 (implicated_via_orthology)
DiseasePustulosis of Palms and Soles

LCE3D NOS2

2.34e-0357372C0030246

Protein segments in the cluster

PeptideGeneStartEntry
QVNGFPCHHGKGHCL

ADAM28

491

Q9UKQ2
AFGHDPHLHGCLQGR

ADGRA1

406

Q86SQ6
GGSRSGSCAHPHHQV

APLP1

121

P51693
PSVGTLCSHGHLHSG

CHRNA2

431

Q15822
LCSHGHLHSGASGPK

CHRNA2

436

Q15822
LQNHRPTGHLSGYCG

ABCA13

4176

Q86UQ4
CGAHGHCHNTPGSFR

FBN3

2496

Q75N90
HTRDGQGPLHHGVCS

NOS2

931

P35228
SQRPHSRGHTHGQAG

FLG2

1816

Q5D862
QCQRHGPVHCSHGGG

LOXL4

506

Q96JB6
RLCGQNLHGQSPHGQ

CBFA2T2

541

O43439
HGCAPTTGQHLHHAL

PLK5

316

Q496M5
YHHRRGTLCHGCGQP

LPXN

321

O60711
PGHHGLALGNSALHH

GGA3

501

Q9NZ52
PGPAHHSCHQSNSNG

NR1D1

371

P20393
NPGALCSPQSQRHGH

FRK

31

P42685
CGLTFIHPAGHGLCH

C2orf83

86

Q53S99
QHCPSPRGENQHGHS

CPLANE1

3001

Q9H799
NHQNLTHCSRHGSGP

CRTC2

601

Q53ET0
GLTPLHCGARSGHEQ

ANK3

301

Q12955
GSQKGPHGLRHHSCS

KLHDC9

251

Q8NEP7
PGAHGSCHRAAQSRG

KHNYN

326

O15037
PSSEGGCFLNHHRRH

LCE3D

46

Q9BYE3
PSSEGGCFLNHHRRH

LCE3E

46

Q5T5B0
PGLGHLVSLHLQHCG

CHADL

446

Q6NUI6
RLSGGLPGHSHCCAH

GPRIN2

281

O60269
AHGLQNMHHALCPGH

GRM1

421

Q13255
HLPVHQDGSCNGLQH

POLRMT

916

O00411
LQPRGGSQEHGLCAH

NLRP3

451

Q96P20
HQGGITHLCFHPDGN

WRAP53

366

Q9BUR4
EGPKLARHSQGHCGH

FYB2

451

Q5VWT5
ACGQPSPHGSHSHAQ

ZFR2

131

Q9UPR6
CPQHSPCGGSSQNHH

RNF111

481

Q6ZNA4
PCGGSSQNHHALGHP

RNF111

486

Q6ZNA4
LGNSRHGHHGPGAQC

STT3B

26

Q8TCJ2
HGHHGPGAQCAHKAA

STT3B

31

Q8TCJ2
PHGLIATGGNDHNIC

PLAA

81

Q9Y263
HGHGGCSPHANCTKV

STAB1

1461

Q9NY15
HCPRGRGSQCGHGHD

SCART1

306

Q4G0T1
PHCHHAHGRELLNGA

TECPR2

571

O15040
SSGGHQGPHRNLHLC

ZSWIM8

1266

A7E2V4
GEFTCHARHPLGSQH

SIGLEC10

421

Q96LC7
CGRGFSHGQHLARHP

ZNF467

436

Q7Z7K2