Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhydrolase activity, acting on glycosyl bonds

TLR10 KL GANAB ACER1 TLR1 TLR6 OGG1 CEMIP

1.50e-07144838GO:0016798
GeneOntologyMolecularFunctionToll-like receptor 2 binding

TLR10 TLR1 TLR6

2.76e-074833GO:0035663
GeneOntologyMolecularFunctionlipopeptide binding

TLR10 TLR1 TLR6

8.14e-0610833GO:0071723
GeneOntologyMolecularFunctionhydrolase activity, hydrolyzing N-glycosyl compounds

TLR10 TLR1 TLR6 OGG1

2.50e-0541834GO:0016799
GeneOntologyMolecularFunctionNAD+ nucleotidase, cyclic ADP-ribose generating

TLR10 TLR1 TLR6

3.73e-0516833GO:0061809
GeneOntologyMolecularFunctionglycosyltransferase activity

UGT8 PGAP4 CHPF2 ST3GAL2 GALNT6 STT3B PARP12

1.97e-04288837GO:0016757
GeneOntologyMolecularFunctionToll-like receptor binding

TLR10 TLR1 TLR6

2.34e-0429833GO:0035325
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen

DEGS2 CMAHP

3.54e-047832GO:0016716
GeneOntologyMolecularFunctionhydrolase activity, hydrolyzing O-glycosyl compounds

KL GANAB ACER1 CEMIP

8.98e-04103834GO:0004553
GeneOntologyMolecularFunctionoxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

SCD DEGS2

1.29e-0313832GO:0016717
GeneOntologyBiologicalProcesscellular response to bacterial lipoprotein

TLR10 TLR1 TLR6

7.39e-0610833GO:0071220
GeneOntologyBiologicalProcesscellular response to bacterial lipopeptide

TLR10 TLR1 TLR6

7.39e-0610833GO:0071221
GeneOntologyBiologicalProcessresponse to bacterial lipopeptide

TLR10 TLR1 TLR6

7.39e-0610833GO:0070339
GeneOntologyBiologicalProcessresponse to bacterial lipoprotein

TLR10 TLR1 TLR6

1.01e-0511833GO:0032493
GeneOntologyBiologicalProcessmembrane lipid biosynthetic process

ACER1 GAL3ST3 UGT8 PGAP4 ST3GAL2 DEGS2

4.11e-05157836GO:0046467
GeneOntologyBiologicalProcessdetection of bacterial lipopeptide

TLR1 TLR6

4.79e-053832GO:0070340
GeneOntologyBiologicalProcessdetection of bacterial lipoprotein

TLR1 TLR6

9.55e-054832GO:0042494
DomainToll-like_receptor

TLR10 TLR1 TLR6

8.11e-075823IPR017241
DomainCA-VB_mt

CA5B CA5A

1.90e-052822IPR018437
DomainEIF3C_N_dom

EIF3C EIF3CL

1.90e-052822IPR008905
DomaineIF-3c_N

EIF3C EIF3CL

1.90e-052822PF05470
DomainEIF3C

EIF3C EIF3CL

1.90e-052822IPR027516
DomainTIR

TLR10 TLR1 TLR6

1.02e-0421823SM00255
DomainTIR

TLR10 TLR1 TLR6

1.18e-0422823PF01582
Domain-

TLR10 TLR1 TLR6

1.36e-04238233.40.50.10140
DomainTIR

TLR10 TLR1 TLR6

1.54e-0424823PS50104
DomainTIR_dom

TLR10 TLR1 TLR6

1.75e-0425823IPR000157
DomainFA_desaturase_dom

SCD DEGS2

5.24e-048822IPR005804
DomainFA_desaturase

SCD DEGS2

5.24e-048822PF00487
DomainNa_channel_asu

SCN4A SCN8A

8.38e-0410822IPR001696
DomainNa_trans_assoc

SCN4A SCN8A

8.38e-0410822IPR010526
DomainNa_trans_assoc

SCN4A SCN8A

8.38e-0410822PF06512
DomainAdipoR/HlyIII-related

MMD ADIPOR2

1.02e-0311822IPR004254
DomainHlyIII

MMD ADIPOR2

1.02e-0311822PF03006
DomainCarbonic_anhydrase_a-class_CS

CA5B CA5A

1.22e-0312822IPR018338
DomainRas_G-nucl-exch_fac_CS

SOS1 SOS2

1.67e-0314822IPR019804
DomainCarbonic_anhydrase_a-class

CA5B CA5A

1.93e-0315822IPR023561
DomainALPHA_CA_1

CA5B CA5A

1.93e-0315822PS00162
DomainChannel_four-helix_dom

CACNA1S SCN4A SCN8A

2.01e-0357823IPR027359
Domain-

CACNA1S SCN4A SCN8A

2.01e-03578231.20.120.350
DomainPINT

EIF3C EIF3CL

2.20e-0316822SM00088
DomainALPHA_CA_2

CA5B CA5A

2.48e-0317822PS51144
DomainPCI_dom

EIF3C EIF3CL

2.48e-0317822IPR000717
DomainCarb_anhydrase

CA5B CA5A

2.48e-0317822PF00194
DomainPCI

EIF3C EIF3CL

2.48e-0317822PF01399
DomainCarb_anhydrase

CA5B CA5A

2.48e-0317822SM01057
Domain-

CA5B CA5A

2.48e-03178223.10.200.10
DomainCarbonic_anhydrase_a

CA5B CA5A

2.48e-0317822IPR001148
Domain-

CLASP1 ARMC12 RTTN SERAC1 HEATR1

2.95e-032228251.25.10.10
DomainRasGEFN

SOS1 SOS2

3.44e-0320822SM00229
DomainIQ

SCN4A MYO1F SCN8A

3.76e-0371823PF00612
DomainARM-type_fold

VPS11 CLASP1 ARMC12 RTTN SERAC1 HEATR1

3.77e-03339826IPR016024
DomainRasGEF_N

SOS1 SOS2

3.79e-0321822PF00618
DomainRas-like_Gua-exchang_fac_N

SOS1 SOS2

4.15e-0322822IPR000651
DomainRASGEF_NTER

SOS1 SOS2

4.15e-0322822PS50212
DomainIQ

SCN4A MYO1F SCN8A

5.44e-0381823SM00015
DomainRASGEF

SOS1 SOS2

5.78e-0326822PS00720
DomainARM-like

CLASP1 ARMC12 RTTN SERAC1 HEATR1

6.72e-03270825IPR011989
DomainRASGEF_CAT

SOS1 SOS2

7.16e-0329822PS50009
DomainCys-rich_flank_reg_C

TLR10 TLR1 TLR6

7.28e-0390823IPR000483
DomainLRRCT

TLR10 TLR1 TLR6

7.28e-0390823SM00082
DomainIQ_motif_EF-hand-BS

SCN4A MYO1F SCN8A

7.28e-0390823IPR000048
DomainRasGEF

SOS1 SOS2

7.65e-0330822PF00617
Domain-

SOS1 SOS2

7.65e-03308221.10.840.10
DomainRas_GEF_dom

SOS1 SOS2

7.65e-0330822IPR023578
DomainRASGEF_cat_dom

SOS1 SOS2

7.65e-0330822IPR001895
DomainRasGEF

SOS1 SOS2

7.65e-0330822SM00147
DomainIQ

SCN4A MYO1F SCN8A

7.97e-0393823PS50096
DomainLRRCT

TLR1 TLR6

8.67e-0332822PF01463
PathwayWP_MYD88_DISTINCT_INPUTOUTPUT_PATHWAY

TLR10 TLR1 TLR6

5.16e-0518583M39478
PathwayREACTOME_DISEASES_OF_IMMUNE_SYSTEM

TLR10 TLR1 TLR6

3.01e-0432583M27428
PathwayKEGG_SPHINGOLIPID_METABOLISM

ACER1 UGT8 DEGS2

5.44e-0439583M15955
PathwayREACTOME_SPHINGOLIPID_METABOLISM

ACER1 UGT8 ST3GAL2 DEGS2

5.51e-0492584MM15086
PathwayKEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_PATHWAY_ADAPTOR_PROTEINS

SOS1 SOS2

7.33e-0410582M47930
PathwayREACTOME_INTERLEUKIN_15_SIGNALING

SOS1 SOS2

8.93e-0411582MM15578
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_RALGDS_SIGNALING_PATHWAY

SOS1 SOS2

8.93e-0411582M47436
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_RASSF1_SIGNALING_PATHWAY

SOS1 SOS2

8.93e-0411582M47432
PathwayREACTOME_SPHINGOLIPID_METABOLISM

ACER1 UGT8 ST3GAL2 DEGS2

9.71e-04107584M14857
PathwayREACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE

CA5B CA5A

1.07e-0312582M671
PathwayREACTOME_REVERSIBLE_HYDRATION_OF_CARBON_DIOXIDE

CA5B CA5A

1.07e-0312582MM14574
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_JNK_SIGNALING_PATHWAY

SOS1 SOS2

1.26e-0313582M47594
PathwayREACTOME_ACTIVATION_OF_RAC1

SOS1 SOS2

1.26e-0313582M6322
PathwayKEGG_MEDICUS_VARIANT_BCR_ABL_FUSION_KINASE_TO_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.47e-0314582M47364
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_KIT_TO_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.47e-0314582M47365
PathwayKEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.47e-0314582M47366
PathwayKEGG_MEDICUS_VARIANT_DUPLICATION_OR_MUTATION_ACTIVATED_FLT3_TO_RAS_PI3K_SIGNALING_PATHWAY

SOS1 SOS2

1.47e-0314582M47390
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_PDGFR_TO_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.47e-0314582M47378
PathwayREACTOME_INTERLEUKIN_15_SIGNALING

SOS1 SOS2

1.47e-0314582M27858
PathwayKEGG_MEDICUS_VARIANT_MET_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.47e-0314582M47488
PathwayREACTOME_GLYCOSAMINOGLYCAN_METABOLISM

HS3ST6 CHPF2 ST3GAL2 CEMIP

1.63e-03123584MM14623
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_MET_TO_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.69e-0315582M47367
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_PI3K_SIGNALING_PATHWAY

SOS1 SOS2

1.69e-0315582M47389
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_EGFR_TO_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.69e-0315582M47375
PathwayKEGG_MEDICUS_VARIANT_AMPLIFIED_FGFR_TO_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.69e-0315582M47380
PathwayKEGG_MEDICUS_REFERENCE_CA2_PYK2_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.69e-0315582M47592
PathwayKEGG_MEDICUS_PATHOGEN_HBV_HBX_TO_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.69e-0315582M47593
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_FGF17_TO_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.69e-0315582M47640
PathwayKEGG_MEDICUS_VARIANT_IGF2_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.69e-0315582M47485
PathwayKEGG_MEDICUS_REFERENCE_HGF_MET_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.69e-0315582M47473
PathwayKEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.69e-0315582M47474
PathwayKEGG_MEDICUS_REFERENCE_FLT3LG_FLT3_RAS_PI3K_SIGNALING_PATHWAY

SOS1 SOS2

1.69e-0315582M47475
PathwayKEGG_MEDICUS_REFERENCE_TGFA_EGFR_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.69e-0315582M47480
PathwayKEGG_MEDICUS_VARIANT_EGF_OVEREXPRESSION_TO_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.69e-0315582M47495
PathwayKEGG_MEDICUS_REFERENCE_EREG_EGFR_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.69e-0315582M47496
PathwayKEGG_MEDICUS_REFERENCE_AREG_EGFR_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.69e-0315582M47497
PathwayKEGG_MEDICUS_REFERENCE_KITLG_KIT_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.69e-0315582M47472
PathwayKEGG_MEDICUS_PATHOGEN_HCMV_GB_TO_PDGFR_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.69e-0315582M47535
PathwayKEGG_MEDICUS_PATHOGEN_HPV_E5_TO_EGFR_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.69e-0315582M47531
PathwayREACTOME_GLYCOSAMINOGLYCAN_METABOLISM

HS3ST6 CHPF2 ST3GAL2 CEMIP

1.78e-03126584M695
PathwayKEGG_MEDICUS_REFERENCE_EGF_EGFR_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.92e-0316582M47363
PathwayKEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_FGFR3_TO_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.92e-0316582M47373
PathwayKEGG_MEDICUS_REFERENCE_EGF_ERBB2_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.92e-0316582M47381
PathwayKEGG_MEDICUS_REFERENCE_P4_PR_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.92e-0316582M47804
PathwayWP_MAPK_PATHWAY_IN_CONGENITAL_THYROID_CANCER

SOS1 SOS2

1.92e-0316582M39882
PathwayKEGG_MEDICUS_REFERENCE_IGF_IGF1R_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

1.92e-0316582M47483
PathwayREACTOME_TIE2_SIGNALING

GRB14 SOS1

2.17e-0317582MM14836
PathwayKEGG_MEDICUS_REFERENCE_PDGF_PDGFR_RAS_ERK_SIGNALING_PATHWAY

SOS1 SOS2

2.17e-0317582M47376
PathwayREACTOME_IRAK4_DEFICIENCY_TLR2_4

TLR1 TLR6

2.44e-0318582M27464
PathwayREACTOME_TIE2_SIGNALING

GRB14 SOS1

2.44e-0318582M11932
PathwayREACTOME_GLYCOSPHINGOLIPID_BIOSYNTHESIS

UGT8 ST3GAL2

2.72e-0319582MM17075
PathwayREACTOME_GLYCOSPHINGOLIPID_BIOSYNTHESIS

UGT8 ST3GAL2

2.72e-0319582M48041
Pubmed

Genetic variation in the toll-like receptor gene cluster (TLR10-TLR1-TLR6) and prostate cancer risk.

TLR10 TLR1 TLR6

1.36e-08384318752252
Pubmed

Polymorphisms in TLR1, TLR6 and TLR10 genes and the risk of Graves' disease.

TLR10 TLR1 TLR6

1.36e-08384325028161
Pubmed

[Association of polymorphisms in toll-like receptor genes with atopic dermatitis in the Republic of Bashkortostan].

TLR10 TLR1 TLR6

1.36e-08384325850295
Pubmed

Genetic variation in the Toll-like receptor gene cluster (TLR10-TLR1-TLR6) influences disease course in sarcoidosis.

TLR10 TLR1 TLR6

1.36e-08384322150367
Pubmed

Sequence variants in Toll-like receptor gene cluster (TLR6-TLR1-TLR10) and prostate cancer risk.

TLR10 TLR1 TLR6

1.36e-08384315812078
Pubmed

Epistatic effect of TLR-1, -6 and -10 polymorphisms on organic dust-mediated cytokine response.

TLR10 TLR1 TLR6

1.36e-08384328123183
Pubmed

Full-exon resequencing reveals toll-like receptor variants contribute to human susceptibility to tuberculosis disease.

TLR10 TLR1 TLR6

1.36e-08384318091991
Pubmed

Association between Toll-like receptor gene cluster (TLR6, TLR1, and TLR10) and prostate cancer.

TLR10 TLR1 TLR6

1.36e-08384317932345
Pubmed

Variation in the TLR10/TLR1/TLR6 locus is the major genetic determinant of interindividual difference in TLR1/2-mediated responses.

TLR10 TLR1 TLR6

1.36e-08384323151486
Pubmed

Toll-like receptor heterodimer variants protect from childhood asthma.

TLR10 TLR1 TLR6

5.43e-08484318547625
Pubmed

Polymorphisms in the toll-like receptor 2 subfamily and risk of asthma: a case-control analysis in a Chinese population.

TLR10 TLR1 TLR6

5.43e-08484320815312
Pubmed

Human TLRs 10 and 1 share common mechanisms of innate immune sensing but not signaling.

TLR10 TLR1 TLR6

5.43e-08484320348427
Pubmed

Toll-like receptor gene polymorphisms confer susceptibility to graft-versus-host disease in allogenic hematopoietic stem cell transplantation.

TLR10 TLR1 TLR6

1.35e-07584322703024
Pubmed

Interactions of sequence variants in interleukin-1 receptor-associated kinase4 and the toll-like receptor 6-1-10 gene cluster increase prostate cancer risk.

TLR10 TLR1 TLR6

1.35e-07584316537705
Pubmed

A pooled investigation of Toll-like receptor gene variants and risk of non-Hodgkin lymphoma.

TLR10 TLR1 TLR6

1.35e-07584319029192
Pubmed

Structural and functional understanding of the toll-like receptors.

TLR10 TLR1 TLR6

2.70e-07684333576548
Pubmed

Isolated Toll-like receptor transmembrane domains are capable of oligomerization.

TLR10 TLR1 TLR6

4.72e-07784323155421
Pubmed

Polymorphisms of toll like receptors in the genetics of severe RSV associated diseases.

TLR10 TLR1 TLR6

4.72e-07784318776592
Pubmed

Identification of genetic loci associated with Helicobacter pylori serologic status.

TLR10 TLR1 TLR6

4.72e-07784323652523
Pubmed

Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens.

TLR10 TLR1 TLR6

7.54e-07884311561001
Pubmed

[Expression of toll-like receptors in human epidermal keratinocytes].

TLR10 TLR1 TLR6

1.61e-061084318686608
Pubmed

Polymorphisms in innate immunity genes associated with development of bronchiolitis obliterans after lung transplantation.

TLR10 TLR1 TLR6

1.61e-061084320227302
Pubmed

Toll-like receptors.

TLR10 TLR1 TLR6

1.61e-061084311782555
Pubmed

A family of human receptors structurally related to Drosophila Toll.

TLR10 TLR1 TLR6

1.61e-06108439435236
Pubmed

Toll-like receptors.

TLR10 TLR1 TLR6

2.21e-061184318394314
Pubmed

Polymorphisms in interleukin-1 receptor-associated kinase 4 are associated with total serum IgE.

TLR10 TLR1 TLR6

2.94e-061284319254290
Pubmed

Polymorphisms of innate pattern recognition receptors, response to interferon-beta and development of neutralizing antibodies in multiple sclerosis patients.

TLR10 TLR1 TLR6

4.85e-061484320595247
Pubmed

Species-specific recognition of Aspergillus fumigatus by Toll-like receptor 1 and Toll-like receptor 6.

TLR1 TLR6

5.76e-06284222315281
Pubmed

Role of TLR1 and TLR6 in the host defense against disseminated candidiasis.

TLR1 TLR6

5.76e-06284218036178
Pubmed

Toll-like receptor 1 and 10 polymorphisms, Helicobacter pylori susceptibility and risk of gastric lesions in a high-risk Chinese population.

TLR10 TLR1

5.76e-06284225687912
Pubmed

The association of genetic variants in toll-like receptor 2 subfamily with allergy and asthma after hospitalization for bronchiolitis in infancy.

TLR1 TLR6

5.76e-06284224445834
Pubmed

[DISTRIBUTION OF TWO-LOCUS HAPLOTYPES OF MICROBIAL COMPONENT SENSOR GENES TLR1 AND TLR6 IN MAJOR POPULATIONS OF SOUTH URALS].

TLR1 TLR6

5.76e-06284226470427
Pubmed

Carbonic anhydrase activators: an activation study of the human mitochondrial isoforms VA and VB with amino acids and amines.

CA5B CA5A

5.76e-06284217174092
Pubmed

Targeted mutagenesis of mitochondrial carbonic anhydrases VA and VB implicates both enzymes in ammonia detoxification and glucose metabolism.

CA5B CA5A

5.76e-06284223589845
Pubmed

Absence of ion channels CACN1AS and SCN4A mutations in thyrotoxic hypokalemic periodic paralysis.

CACNA1S SCN4A

5.76e-06284215072700
Pubmed

Association of human TLR1 and TLR6 deficiency with altered immune responses to BCG vaccination in South African infants.

TLR1 TLR6

5.76e-06284221852947
Pubmed

Toll-like Receptor 1 743 A>G, 1805 T>G & Toll-like Receptor 6 745 C>T gene polymorphism and tuberculosis: a case control study of north Indian population from Agra (India).

TLR1 TLR6

5.76e-06284224984237
Pubmed

Synergistic effect of genetic polymorphisms in TLR6 and TLR10 genes on the risk of pulmonary tuberculosis in a Moldavian population.

TLR10 TLR6

5.76e-06284234275341
Pubmed

A homologue of the Drosophila Son of sevenless gene maps to mouse chromosome 17.

SOS1 SOS2

5.76e-0628428307589
Pubmed

EIF3C Promotes Lung Cancer Tumorigenesis by Regulating the APP/HSPA1A/LMNB1 Axis.

EIF3C EIF3CL

5.76e-06284236157221
Pubmed

Cutting edge: functional interactions between toll-like receptor (TLR) 2 and TLR1 or TLR6 in response to phenol-soluble modulin.

TLR1 TLR6

5.76e-06284211123271
Pubmed

SNPs in the exons of Toll-like receptors are associated with susceptibility to type 1 diabetes in Chinese population.

TLR1 TLR6

5.76e-06284225261617
Pubmed

Mutation analysis of CACNA1S and SCN4A in patients with hypokalemic periodic paralysis.

CACNA1S SCN4A

5.76e-06284226252573
Pubmed

Polymorphisms at Locus 4p14 of Toll-Like Receptors TLR-1 and TLR-10 Confer Susceptibility to Gastric Carcinoma in Helicobacter pylori Infection.

TLR10 TLR1

5.76e-06284226559190
Pubmed

Absence of both Sos-1 and Sos-2 in peripheral CD4(+) T cells leads to PI3K pathway activation and defects in migration.

SOS1 SOS2

5.76e-06284225973715
Pubmed

Genetic ancestry effects on the distribution of toll-like receptors (TLRs) gene polymorphisms in a population of the Atlantic Forest, São Paulo, Brazil.

TLR1 TLR6

5.76e-06284229175392
Pubmed

Voltage sensor charge loss accounts for most cases of hypokalemic periodic paralysis.

CACNA1S SCN4A

5.76e-06284219118277
Pubmed

Voltage-dependent Ca2+ release is impaired in hypokalemic periodic paralysis caused by CaV1.1-R528H but not by NaV1.4-R669H.

CACNA1S SCN4A

5.76e-06284235759432
Pubmed

The Roles of TLR Gene Polymorphisms in Atherosclerosis: A Systematic Review and Meta-Analysis of 35,317 Subjects.

TLR1 TLR6

5.76e-06284228474755
Pubmed

Topiramate treatment protects blood-brain barrier pericytes from hyperglycemia-induced oxidative damage in diabetic mice.

CA5B CA5A

5.76e-06284222109883
Pubmed

Identification of murine homologues of the Drosophila son of sevenless gene: potential activators of ras.

SOS1 SOS2

5.76e-0628421631150
Pubmed

Toll-like receptor 1 and 10 variations increase asthma risk and review highlights further research directions.

TLR10 TLR1

5.76e-06284230924193
Pubmed

SOS2 Comes to the Fore: Differential Functionalities in Physiology and Pathology.

SOS1 SOS2

5.76e-06284234205562
Pubmed

Defective hepatic bicarbonate production due to carbonic anhydrase VA deficiency leads to early-onset life-threatening metabolic crisis.

CA5B CA5A

5.76e-06284226913920
Pubmed

The Ras-specific exchange factors mouse Sos1 (mSos1) and mSos2 are regulated differently: mSos2 contains ubiquitination signals absent in mSos1.

SOS1 SOS2

5.76e-0628429372945
Pubmed

Mutations associated with hypokalemic periodic paralysis: from hotspot regions to complete analysis of CACNA1S and SCN4A genes.

CACNA1S SCN4A

5.76e-06284234608571
Pubmed

Toll-like receptor 1 and 10 gene polymorphisms are linked to postbronchiolitis asthma in adolescence.

TLR10 TLR1

5.76e-06284228692144
Pubmed

Genotype and phenotype analysis of patients with sporadic periodic paralysis.

CACNA1S SCN4A

5.76e-06284221841462
Pubmed

Critical Requirement of SOS1 for Development of BCR/ABL-Driven Chronic Myelogenous Leukemia.

SOS1 SOS2

5.76e-06284236010887
Pubmed

Mitochondrial carbonic anhydrase VA and VB: properties and roles in health and disease.

CA5B CA5A

5.76e-06284236464834
Pubmed

A specific role for TLR1 in protective T(H)17 immunity during mucosal infection.

TLR1 TLR6

5.76e-06284222778390
Pubmed

Chromosomal localization of two genes encoding human ras exchange factors: SOS1 maps to the 2p22-->p16 region and SOS2 to the 14q21-->q22 region of the human genome.

SOS1 SOS2

5.76e-0628428275713
Pubmed

Mitochondrial carbonic anhydrase CA VB: differences in tissue distribution and pattern of evolution from those of CA VA suggest distinct physiological roles.

CA5B CA5A

5.76e-06284210677517
Pubmed

Genetic polymorphisms in TLR1, TLR2, TLR4, and TLR10 of Helicobacter pylori-associated gastritis: a prospective cross-sectional study in Thailand.

TLR10 TLR1

5.76e-06284228368946
Pubmed

Natural selection in the TLR-related genes in the course of primate evolution.

TLR10 TLR1 TLR6

7.44e-061684318810425
Pubmed

Binding specificity of Toll-like receptor cytoplasmic domains.

TLR10 TLR1 TLR6

1.28e-051984316482509
Pubmed

Toll-like receptor signaling pathway variants and prostate cancer mortality.

TLR10 TLR1 TLR6

1.28e-051984319505919
Pubmed

Heterozygous Arg753Gln polymorphism of human TLR-2 impairs immune activation by Borrelia burgdorferi and protects from late stage Lyme disease.

TLR1 TLR6

1.73e-05384216081826
Pubmed

Sublethal infection of C57BL/6 mice with Salmonella enterica Serovar Typhimurium leads to an increase in levels of Toll-like receptor 1 (TLR1), TLR2, and TLR9 mRNA as well as a decrease in levels of TLR6 mRNA in infected organs.

TLR1 TLR6

1.73e-05384215731092
Pubmed

Recognition of Coxiella burnetii by toll-like receptors and nucleotide-binding oligomerization domain-like receptors.

TLR1 TLR6

1.73e-05384225246533
Pubmed

The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors.

TLR1 TLR6

1.73e-05384211095740
Pubmed

IFNs activate toll-like receptor gene expression in viral infections.

TLR1 TLR6

1.73e-05384211607792
Pubmed

Association of 4p14 TLR locus with antibodies to Helicobacter pylori.

TLR10 TLR6

1.73e-05384226312625
Pubmed

Ureaplasma parvum lipoproteins, including MB antigen, activate NF-{kappa}B through TLR1, TLR2 and TLR6.

TLR1 TLR6

1.73e-05384218451040
Pubmed

TLR1- and TLR6-independent recognition of bacterial lipopeptides.

TLR1 TLR6

1.73e-05384216455646
Pubmed

Toll-like receptor polymorphisms are associated with increased neurosyphilis risk.

TLR1 TLR6

1.73e-05384224922103
Pubmed

Functional redundancy of Sos1 and Sos2 for lymphopoiesis and organismal homeostasis and survival.

SOS1 SOS2

1.73e-05384224043312
Pubmed

Molecular mechanisms of TLR2-mediated antigen cross-presentation in dendritic cells.

TLR1 TLR6

1.73e-05384224683188
Pubmed

A dipalmitoylated lipoprotein from Mycoplasma pneumoniae activates NF-kappa B through TLR1, TLR2, and TLR6.

TLR1 TLR6

1.73e-05384216177110
Pubmed

Mutation spectrum and health status in skeletal muscle channelopathies in Japan.

CACNA1S SCN4A

1.73e-05384232660787
Pubmed

Toll-like receptor 1, 2 and 6 polymorphisms: no association with 11 serum cytokine concentrations.

TLR1 TLR6

1.73e-05384230028533
Pubmed

Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS.

SOS1 SOS2

1.73e-05384212628188
Pubmed

Differential Role of the RasGEFs Sos1 and Sos2 in Mouse Skin Homeostasis and Carcinogenesis.

SOS1 SOS2

1.73e-05384229844066
Pubmed

Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer.

TLR1 TLR6

1.73e-05384219931471
Pubmed

Hypokalemic Periodic Paralysis

CACNA1S SCN4A

1.73e-05384220301512
Pubmed

Divergent roles of amino acid residues inside and outside the BB loop affect human Toll-like receptor (TLR)2/2, TLR2/1 and TLR2/6 responsiveness.

TLR1 TLR6

1.73e-05384223626692
Pubmed

Atherosclerosis induced by endogenous and exogenous toll-like receptor (TLR)1 or TLR6 agonists.

TLR1 TLR6

1.73e-05384222822027
Pubmed

TLR1, TLR2, and TLR6 gene polymorphisms are associated with increased susceptibility to complicated skin and skin structure infections.

TLR1 TLR6

1.73e-05384224511099
Pubmed

TLR1 and TLR6 polymorphisms are associated with susceptibility to invasive aspergillosis after allogeneic stem cell transplantation.

TLR1 TLR6

1.73e-05384216461792
Pubmed

Toll-like receptor 2 subfamily gene polymorphisms are associated with Bacillus Calmette-Guérin osteitis following newborn vaccination.

TLR1 TLR6

1.73e-05384225605403
Pubmed

Saturated fatty acid activates but polyunsaturated fatty acid inhibits Toll-like receptor 2 dimerized with Toll-like receptor 6 or 1.

TLR1 TLR6

1.73e-05384214966134
Pubmed

Toll-like receptor 2 subfamily genotypes are not associated with severity of bronchiolitis or postbronchiolitis wheezing in infants.

TLR1 TLR6

1.73e-05384224112285
Pubmed

Deconstructing Ras signaling in the thymus.

SOS1 SOS2

1.73e-05384222586275
Pubmed

Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins.

TLR1 TLR6

1.73e-05384212077222
Pubmed

Toll-like receptors 1 and 6 are involved in TLR2-mediated macrophage activation by hepatitis C virus core and NS3 proteins.

TLR1 TLR6

1.73e-05384217595379
Pubmed

Disassembly of Son-of-sevenless proteins from Grb2 during p21ras desensitization by insulin.

SOS1 SOS2

1.73e-0538427829473
Pubmed

Heterodimerization of TLR2 with TLR1 or TLR6 expands the ligand spectrum but does not lead to differential signaling.

TLR1 TLR6

1.73e-05384218056480
Pubmed

Differential interactions of human Sos1 and Sos2 with Grb2.

SOS1 SOS2

1.73e-0538427629138
Pubmed

Toll-like receptor-1, -2, and -6 polymorphisms influence disease extension in inflammatory bowel diseases.

TLR1 TLR6

1.73e-05384216374251
Pubmed

TLR1/TLR2 heterodimers play an important role in the recognition of Borrelia spirochetes.

TLR1 TLR6

1.73e-05384221998742
Cytoband4p14

TLR10 TLR1 TLR6

6.44e-05428434p14
CytobandEnsembl 112 genes in cytogenetic band chr4p14

TLR10 TLR1 TLR6

2.60e-0467843chr4p14
Cytoband5q33.1

FAT2 SLC36A2

1.04e-03268425q33.1
Cytoband6q25.3

NOX3 SERAC1

1.68e-03338426q25.3
Cytoband11q23

IL10RA VPS11

2.00e-033684211q23
GeneFamilyCD molecules|Toll like receptors

TLR10 TLR1 TLR6

4.31e-0610613948
GeneFamilyFatty acid desaturases

SCD DEGS2

3.09e-048612553
GeneFamilySodium voltage-gated channel alpha subunits

SCN4A SCN8A

3.97e-0496121203
GeneFamilyProgestin and adipoQ receptor family

MMD ADIPOR2

6.04e-0411612930
GeneFamilyCarbonic anhydrases

CA5B CA5A

1.65e-0318612460
GeneFamilyADAM metallopeptidase domain containing|CD molecules

TLR10 CXCR5 IL10RA TLR1 BCAM TLR6

2.08e-03394616471
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

ASAP2 GRB14 SOS1 SOS2

5.15e-03206614682
GeneFamilyZinc fingers CCCH-type

UNK PARP12

6.20e-033561273
GeneFamilySulfotransferases, membrane bound

GAL3ST3 HS3ST6

6.91e-0337612763
CoexpressionSTK33_UP

TLR10 IL10RA ZMYND11 BTG2 TLR1 UNK TLR6 SOS1

3.54e-06286838M2858
CoexpressionSTK33_SKM_UP

TLR10 IL10RA BTG2 TLR1 UNK SERAC1 TLR6

2.99e-05279837M2857
CoexpressionGSE29617_DAY3_VS_DAY7_TIV_FLU_VACCINE_PBMC_2008_UP

CACNA1S ZNF628 SLC31A2 ARMC12 GRB14 MFSD5

3.09e-05189836M4933
CoexpressionSTK33_NOMO_UP

IL10RA ZMYND11 BTG2 TLR1 UNK TLR6 SOS1

3.82e-05290837M2855
CoexpressionGSE13485_DAY7_VS_DAY21_YF17D_VACCINE_PBMC_UP

VPS11 ASAP2 CLASP1 GALNT6 HERC5 PARP12

3.90e-05197836M3307
ToppCelldroplet-Lung-1m-Hematologic-lymphocytic-Zbtb32+_B_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CXCR5 CACNA1S SCD SCN4A CMAHP STT3B

1.07e-06177846a58c93be9767e3fe8fbb6b0db1210d3a33aac662
ToppCelldroplet-Lung-1m-Hematologic-lymphocytic-Zbtb32+_B_cell-Zbtb32+_B_cell|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CXCR5 CACNA1S SCD SCN4A CMAHP STT3B

1.07e-061778463ed383e5c0b15d9d5e75b98cf6d10609f48fc422
ToppCell10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-C|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CLCN4 SCD DHCR24 LRP2 UGT8 HEPN1

1.72e-061928463ce5dbde41aeb73d49f2c7991d34682f0827fa5a
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CLCN4 SLC31A2 SCD LRP2 UGT8 ADIPOR2

2.12e-06199846214a6a267e77e5508867b9eb48c4fbc7855ed0a0
ToppCellPBMC-Mild-Lymphocyte-B-B_cell-B_intermediate-B_activate-7|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TLR10 CXCR5 OR52R1 UGT8 NOX3

4.61e-0612984558790c6eaa597b8e8209a0fbc970e9cffa10bca5
ToppCellLPS-IL1RA-Endothelial-Mes-Like-Gen_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PCED1B CLCN4 PEX10 GRB14 PARP12

8.16e-0614584590ca38c02325c5c637c32efdef634b54cc3cd105
ToppCellFetal_29-31_weeks-Immune-dendritic_cell-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

TLR10 IL10RA ZFAT CLCN4 ST3GAL2

9.62e-0615084557f21ad380fd1350a2c25d75ad8c3b763ded53ec
ToppCellfacs-Heart-RA-24m-Lymphocytic-B_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CXCR5 CACNA1S SCD SCN4A CMAHP

1.53e-0516584536415924d05373e9dd3665be599f4f3f40bf0497
ToppCellfacs-Heart-RA-24m-Lymphocytic-B_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CXCR5 CACNA1S SCD SCN4A CMAHP

1.53e-0516584556310fddd3d8e4afdfde066d26cee9747e5b8c6a
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_ALM_Npsr1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

NPR3 HS3ST6 UGT8 DNAH9

1.69e-05818445d9b08bc1ae6ecb894c88c9784fdc4203682d087
ToppCellfacs-Marrow-KLS-3m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CXCR5 SCD TLR1 UGT8 CMAHP

1.71e-05169845d18b823836ca6fba79a2d2f10cb9966fa2623af2
ToppCellfacs-Marrow-KLS-3m-Lymphocytic-naive_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CXCR5 SCD TLR1 UGT8 CMAHP

1.71e-05169845befb9b1618ea30fbf8983bcc493853da53b809c3
ToppCellfacs-Thymus-Flowthrough-3m-Myeloid|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CXCR5 IL10RA SCD LOXL4 ELMOD3

1.86e-05172845356a66cd9303470e427005cc67fdd22a2c4bf971
ToppCellfacs-Thymus-Flowthrough-3m-Myeloid-macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CXCR5 IL10RA SCD LOXL4 ELMOD3

1.86e-0517284546fadeee483fdf8402df92ec98575a09c6c15b16
ToppCellfacs-Thymus-Flowthrough-3m-Myeloid-macrophage|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CXCR5 IL10RA SCD LOXL4 ELMOD3

1.86e-05172845438d2e7f1897668a14d85ca70722e5d0102606dc
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CXCR5 SCD SCN4A LRP2 DNAH9

2.08e-05176845c6484334187f64cd00cd35e77d8ae436556b4260
ToppCelldroplet-Lung-nan-21m-Lymphocytic-Zbtb32+_B|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CXCR5 CACNA1S SCD SCN4A CMAHP

2.08e-05176845741fdacb33d49b030a797a6099fdea0949a22e75
ToppCellRV-11._Adipocyte|RV / Chamber and Cluster_Paper

PCED1B SCD ELMOD3 ADIPOR2 HEPN1

2.20e-05178845278bbea5cf8f0589f71675c7a3d00679391b5253
ToppCelldroplet-Lung-LUNG-1m-Lymphocytic-Zbtb32+_B|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CXCR5 SCD SCN4A CMAHP STT3B

2.20e-051788459b932b677ae05ac6e12cd6ce97789f8c10e4790b
ToppCelldroplet-Lung-nan-21m-Lymphocytic-B_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CXCR5 CACNA1S SCD SCN4A CMAHP

2.32e-05180845b673d11d764e275883fc5edbad97137a6549df6a
ToppCellLPS-IL1RA-Myeloid-Monocytes,_Macrophages-Monocytes-Macrophages|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IL10RA SLC31A2 TLR1 MYO1F P2RY8

2.32e-0518084597241f62ee133dcb0d4855ffda5dd1349de9f7b2
ToppCellLPS-IL1RA-Myeloid-Monocytes,_Macrophages|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IL10RA SLC31A2 TLR1 MYO1F P2RY8

2.32e-0518084541896546cd1cc458e08c0d4e19aa4860e5d4fcd6
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_MOBP_COL18A1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC31A2 SCD LRP2 UGT8 GALNT6

2.44e-05182845d524ad5cf00f05ee27c9db2ffa2d4e30a1e2e21a
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC31A2 SCD LRP2 UGT8 GALNT6

2.51e-051838455472cdce6d99314d229418412acf1fff6340db7d
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC31A2 SCD LRP2 UGT8 GALNT6

2.51e-0518384593213124e55d1b673dd345188caf8b5bd31d99fe
ToppCellfacs-Limb_Muscle-ForelimbandHindlimb-3m-Lymphocytic-B_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CXCR5 IL10RA SCD TLR1 CMAHP

2.51e-0518384520f7b6ec2462032eda957a893ca76d5a5a01333d
ToppCellAnterior_Cingulate_gyrus_(CgG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC31A2 SCD LRP2 UGT8 GALNT6

2.57e-05184845f6d6b3ddada66dae28d3306415bf4efe0934208a
ToppCellPrimary_Visual_cortex_(V1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC31A2 SCD LRP2 UGT8 GALNT6

2.57e-051848455939527d24d299e562e707469c9123890edd76be
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC31A2 SCD LRP2 UGT8 GALNT6

2.64e-051858451d731d69d8db8aef4a11439b8abd1030c7e6ac4c
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC31A2 SCD LRP2 UGT8 GALNT6

2.64e-05185845b8d02c9426740ffcb69d2e6f95473b388149d297
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC31A2 SCD LRP2 UGT8 GALNT6

2.71e-0518684590eaf6ffb4ce0c34fa1e79f0c8f36f217f44973b
ToppCellMid-temporal_gyrus_(MTG)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC31A2 SCD LRP2 UGT8 GALNT6

2.71e-05186845bd8a9753df219084e19e7f94447856e86608325c
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_OPALIN|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC31A2 SCD LRP2 UGT8 GALNT6

2.78e-05187845f0de86ef25e344d9b1860ee26308877d6c25ed31
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC31A2 SCD LRP2 UGT8 GALNT6

2.78e-05187845b71d0cd91bc98e020757c1d071a13ad48d718bcf
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC31A2 SCD LRP2 UGT8 GALNT6

2.85e-0518884514072d0b82df55711d5356b2209f4f0bdd90dc27
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial-Oligo|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC31A2 SCD LRP2 UGT8 GALNT6

2.85e-0518884560242c29c7f16c94a84685d3bc4ed93a66e70152
ToppCellfacs-MAT-Fat-3m-Lymphocytic-B_cell|MAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CXCR5 SCD TLR1 SCN4A CMAHP

2.85e-05188845a7158b5c94e6b356877f016e52f2c24a3f5d24d2
ToppCellprimary_auditory_cortex_(A1C)-Non-neuronal-Macroglial-Oligo|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC31A2 SCD LRP2 UGT8 GALNT6

2.85e-05188845b04fd6a724c117eb9a979c29b91f90113feb7a5c
ToppCelldroplet-Heart-nan-18m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RTTN UGT8 GRB14 GALNT6 SLC36A2

2.93e-051898450493f7b79127c207fd7ade778ef4810500495d7e
ToppCellPrimary_Motor_Cortex_(M1)-Non-neuronal-Macroglial-Oligo-Oligodendrocyte-Oligo_L4-6_MOBP_COL18A1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

SLC31A2 SCD LRP2 UGT8 GALNT6

3.00e-05190845396b7225c2430db3dc55a3d0db70239b71987229
ToppCellcontrol-Lymphoid-B_cell|Lymphoid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

TLR10 CXCR5 BTG2 TLR1 TLR6

3.32e-05194845a5284adca931a78b1c4592925c4860853ebd24f1
ToppCell11.5-Airway-Epithelial-Secretory_progenitor|Airway / Age, Tissue, Lineage and Cell class

BTG2 DHCR24 GRB14 DEGS2 BCAM

3.40e-051958458cbc78a6cb812f907c69b00f85263976216840ac
ToppCellPCW_13-14-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_myeloid_progenitor3_(13)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

TLR10 IL10RA TLR1 MYO1F P2RY8

3.40e-051958455f46f9aca1c7f76416e861aa94d24fc1d6266113
ToppCell5'-GW_trimst-1.5-SmallIntestine-Hematopoietic-Myeloid-Macrophages|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

IL10RA TLR1 MYO1F P2RY8 TLR6

3.65e-0519884588635244a0b306d2cc50b8412fe47bb359c9cf00
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW26-Mesenchymal-BMP_responsible_cell|GW26 / Sample Type, Dataset, Time_group, and Cell type.

PCED1B IL10RA BTG2 MYO1F TLR6

3.83e-05200845cd0d69f973ca3204b500d12031b403a1f4593431
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CLCN4 SLC31A2 SCD LRP2 UGT8

3.83e-05200845acdef0b9096c774040948fc75621ff2b08ea2ee8
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CLCN4 SLC31A2 SCD LRP2 UGT8

3.83e-05200845091a18d6efed81cab99955c3047f172170f70476
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CLCN4 SLC31A2 SCD LRP2 UGT8

3.83e-052008453b8513defe25262ab4b492345b2628570eaefd17
ToppCellBrain_organoid-organoid_Tanaka_cellReport-5w-Mesenchymal-Mesoderm|5w / Sample Type, Dataset, Time_group, and Cell type.

ARMC12 STXBP5L MYO1F EXOC3L1 ZNF639

3.83e-052008450927061536a664b4f7feb9e5b0a8c11ca0d5955c
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW26-Mesenchymal|GW26 / Sample Type, Dataset, Time_group, and Cell type.

PCED1B IL10RA BTG2 MYO1F TLR6

3.83e-0520084516caefcc5bdca82d904462c6fd0ffa80d96fa474
ToppCellBiopsy_Other_PF-Epithelial-Basal|Biopsy_Other_PF / Sample group, Lineage and Cell type

FAT2 LOXL4 PGAP4 BCAM CEMIP

3.83e-052008457098ae4b0ea8ba607519eaed8577c577530fc2a1
ToppCellTCGA-Cervix-Primary_Tumor-Cervical_Carcinoma-Cervical_Squamous_Cell_Carcinoma-3|TCGA-Cervix / Sample_Type by Project: Shred V9

CXCR5 FAT2 ZFAT ELMOD3

8.40e-051228441ed865f0ecfe304fb86313ff51c04e9052357270
ToppCellStriatum-Macroglia-POLYDENDROCYTE-P1-P1_1-Tnr-Polydendrocye.Tnr.Ctps_(Ctps)|Striatum / BrainAtlas - Mouse McCarroll V32

UGT8 GRB14 GALNT6 FHL3

1.21e-04134844bc550d3b44f1e1e1c18971c110e816bcffd79d14
ToppCellStriatum-Macroglia-POLYDENDROCYTE-P1-P1_1-Tnr|Striatum / BrainAtlas - Mouse McCarroll V32

UGT8 GRB14 GALNT6 FHL3

1.21e-0413484490a34ae53a602a92f6f998e7cf061d8f4f0da527
ToppCellPND07-28-samps-Lymphocyte-B_cell-B_cell_2|PND07-28-samps / Age Group, Lineage, Cell class and subclass

CXCR5 TLR1 SCN4A PEX10

1.31e-041378442544d1256f11da6e3bad24a871b2253e0ab20d01
ToppCellfrontal_cortex-Non-neuronal-oligodendrocyte-Oligo-Oligo_Serpinb1a|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SCD UGT8 GRB14 GALNT6

1.31e-04137844ca8fdbe66a854e6283b22179ec9359ea9e86cd8e
ToppCellPND07-28-samps-Lymphocyte-B_cell|PND07-28-samps / Age Group, Lineage, Cell class and subclass

CXCR5 TLR1 SCN4A PEX10

1.31e-04137844874e2eaa7846a2832f46b77c726d79f220a4a1cd
ToppCellLPS-IL1RA-Endothelial-Epi-like-Alv_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

ZMYND11 KL LRP2 BCAM

1.35e-041388445f8ac8f67e34a7cf560099208e6884102532391e
ToppCellCOVID-19-Heart-CM_5_(RYR2-)|COVID-19 / Disease (COVID-19 only), tissue and cell type

CACNA1S SCN4A SLC36A2 CNTFR

1.59e-04144844f92e03dd784e31a9e5dbd4f4c3a6517ea19210cf
ToppCellkidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

NAT8B KL LRP2 SLC36A2

1.63e-0414584447a3bb973a508d3097213a2d86ad1ce697af9bae
ToppCellLPS-IL1RA+antiTNF-Myeloid-Dendritic_cells-Monocytes-Macrophages|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

IL10RA FAT2 MYO1F TLR6

1.68e-04146844b76110b159acd27a2c8d6a9f98336608ace1ec12
ToppCell5'-GW_trimst-1.5-SmallIntestine-Hematopoietic-Myeloid-cDC1|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

TLR10 IL10RA MYO1F P2RY8

1.86e-041508443dc23a37dbeb7f9df93683702a7838f7cc3ec9cc
ToppCellHippocampus-Hematopoietic|Hippocampus / BrainAtlas - Mouse McCarroll V32

IL10RA TLR1 MYO1F TLR6

1.91e-0415184481b2189afd72658f7e2539b856ba79cd49340215
ToppCellLPS-antiTNF-Lymphocytic_NKT-T_cells-Neutrophils|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

MYO1F MMD MFSD5 CEMIP

2.01e-04153844c4dcdcaa672929c1da870e9fb8ada1bb030ad12f
ToppCellCOVID-19-Heart-CM_5_(RYR2-)|Heart / Disease (COVID-19 only), tissue and cell type

CACNA1S SCN4A SLC36A2 CNTFR

2.11e-04155844d7e26696fd9c0a759524f331243db43059b33ed9
ToppCellGlobus_pallidus-Hematopoietic|Globus_pallidus / BrainAtlas - Mouse McCarroll V32

IL10RA TLR1 MYO1F TLR6

2.16e-0415684467cdaadc3b917f7072adce16c0391472c14a2563
ToppCelldroplet-Kidney-KIDNEY-30m-Myeloid-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL10RA MYO1F COL14A1 FHL3

2.16e-041568446e60e860603a7e8194f437a574ff8e887f6083b8
ToppCell343B-Epithelial_cells-Epithelial-H_(AT1)-|343B / Donor, Lineage, Cell class and subclass (all cells)

FAT2 LOXL4 PGAP4 HEPN1

2.22e-04157844dd08dc19d434e94a194076c462ee273c682abf55
ToppCellfacs-Trachea-nan-3m-Myeloid-lymphocyte_of_B_lineage|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL10RA CACNA1S TLR1 SCN4A

2.22e-041578440fecc14959c4c9efc19d5c06475a890e0a30f148
ToppCell343B-Epithelial_cells-Epithelial-H_(AT1)|343B / Donor, Lineage, Cell class and subclass (all cells)

FAT2 LOXL4 PGAP4 HEPN1

2.22e-0415784470fd6c46db4250c7de5c4686a9500689402737f6
ToppCelldroplet-Lung-nan-3m-Lymphocytic-Zbtb32+_B|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CXCR5 SCD SCN4A CMAHP

2.27e-0415884466c011e9de002224f70725dfe8e7871c8d304492
ToppCell343B-Epithelial_cells-Epithelial-H_(AT1)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

FAT2 LOXL4 PGAP4 HEPN1

2.44e-04161844da9eecf919866a9c579d7a707a996cf335213134
ToppCellE16.5-Immune-Immune_Myeloid-Monocytic-Macrophage-IM-IM_G2M|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

IL10RA TLR1 MYO1F TLR6

2.44e-041618445a8698790f9aba796dd2b64af419055c60bd7de8
ToppCell343B-Epithelial_cells-Epithelial-H_(AT1)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

FAT2 LOXL4 PGAP4 HEPN1

2.44e-04161844d431625c32f59a6b552191f3adc5198bd16ad5cf
ToppCelldroplet-Lung-3m-Hematologic-lymphocytic-Zbtb32+_B_cell-Zbtb32+_B_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CXCR5 CACNA1S SCD SCN4A

2.44e-041618447af3b0d4fc7967f6b3e2d255d23fd8b1fd01a7af
ToppCell5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.4.2|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SCD LRP2 ST3GAL2 C5

2.44e-041618441f4614ae15bd2fc08e555cea4d0152c4a940d048
ToppCellTCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Clear_Cell_Renal_Carcinoma-1|TCGA-Kidney / Sample_Type by Project: Shred V9

NPR3 SCN4A P2RY8 EXOC3L1

2.44e-041618446cacae4a759ace763597ee394cff498dc5d96f74
ToppCelldroplet-Lung-3m-Hematologic-lymphocytic-Zbtb32+_B_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

CXCR5 CACNA1S SCD SCN4A

2.44e-0416184498be0cf8228496b31f7f3e0efd8787e95eb626d1
ToppCelldroplet-Marrow-nan-21m-Hematologic-erythroid_progenitor|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PCED1B CACNA1S SCD COL14A1

2.50e-04162844d0ffebf5adee8a3ac9b81a4b793184f54010489a
ToppCellfacs-Lung-Endomucin-24m-Lymphocytic-B_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CXCR5 SCD SCN4A CMAHP

2.56e-041638442a561aa4518cf52d8470eff083b84f942a2b2b5d
ToppCellImmune_cells-B_cell|World / Lineage and Cell class

CXCR5 CACNA1S SCD TLR1

2.56e-041638443a02465de7c2f7cea227e289fb082a1fb6400301
ToppCellE16.5-samps-Mesenchymal-Matrix_fibroblast-_fetal-Mature_Fibroblast_1|E16.5-samps / Age Group, Lineage, Cell class and subclass

NPR3 GAL3ST3 COL14A1 SLC36A2

2.56e-04163844f1ec2625b52664308968b01d8e0275e1e0751480
ToppCell343B-Epithelial_cells-Epithelial-A_(AT2)-|343B / Donor, Lineage, Cell class and subclass (all cells)

FAT2 SCD DHCR24 LRP2

2.62e-04164844beaa13a75c3bb72446c85084d75e9fe3f15fd3d4
ToppCellE18.5-samps-Mesenchymal-Matrix_fibroblast-MatrixFB-A|E18.5-samps / Age Group, Lineage, Cell class and subclass

PCED1B NPR3 COL14A1 SLC36A2

2.62e-04164844519ab4fe885dfe4c50846f346a062acc2cb44299
ToppCell343B-Epithelial_cells-Epithelial-A_(AT2)|343B / Donor, Lineage, Cell class and subclass (all cells)

FAT2 SCD DHCR24 LRP2

2.62e-04164844d005cfd821b87548b075120bffe65a0be9860463
ToppCellfacs-Lung-Endomucin-24m-Lymphocytic-Zbtb32+_B|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CXCR5 SCD SCN4A CMAHP

2.74e-041668446842735750dcb361e4c9844f05233b0fbb879652
ToppCelldroplet-Fat-SCAT-30m-Lymphocytic-B_cell|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CXCR5 CACNA1S CMAHP STT3B

2.74e-041668444b31d2755108b2815316411a38bfb11fd30ef98a
ToppCellfacs-Heart-RA-18m-Lymphocytic-B_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CXCR5 CACNA1S TLR1 CMAHP

2.74e-04166844fc2cf67311c86fda75b35fcd4768b6f6f14c59d0
ToppCell368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)|368C / Donor, Lineage, Cell class and subclass (all cells)

KL EXOC3L1 BCAM HEPN1

2.74e-0416684430a991fc3275b571d53bd0976df4789e5d40b01d
ToppCell10x5'-bone_marrow-Hematopoietic_progenitors-Progenitor_MEMP|bone_marrow / Manually curated celltypes from each tissue

NPR3 GAL3ST3 PGAP4 BCAM

2.74e-041668449788486582cc2c5f28b9ea015e235732f9fefb1e
ToppCelldroplet-Kidney-nan-18m-Epithelial-Epcam____proximal_tube_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NAT8B LRP2 UGT8 DEGS2

2.74e-041668448ab18c9d911eb3a9970bba7a769294b0927538f7
ToppCell368C-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-|368C / Donor, Lineage, Cell class and subclass (all cells)

KL EXOC3L1 BCAM HEPN1

2.74e-0416684476b4cd32698900797ec009f17e50ea7ae36b85f4
ToppCelldroplet-Lung-nan-18m-Lymphocytic-Zbtb32+_B|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CXCR5 CACNA1S SCD CMAHP

2.74e-041668443e3e9296e6919a38602e417a6606c046af3bd101
ToppCellfacs-Heart-RA-18m-Lymphocytic-B_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CXCR5 CACNA1S TLR1 CMAHP

2.74e-0416684433a6876d06e26176135a73a77c19e634ec53f7ce
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

NAT8B SCN4A CA5A

2.76e-04678432c95f09e680d2c5e6edfefa5b933617db5786c60
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)--|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

NAT8B SCN4A CA5A

2.76e-0467843859716ced14c35703c23a538a87621e48eb03aca
ToppCellFrontal_cortex-Endothelial-ENDOTHELIAL_STALK-Flt1_1-Endothelial_Stalk.Flt1.Car4_(Car4)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

NAT8B SCN4A CA5A

2.76e-04678433876baae8344902d517bdff99a920a657a29a150
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

STXBP5L LRP2 DNAH9 CA5A

2.80e-041678443edb0570e583bb527165bcd8a4c25a042054043b
ToppCelldroplet-Kidney-nan-18m-Epithelial-Epcam____brush_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SCD LRP2 LOXL4 CA5A

2.80e-04167844ed7e785dcd25777f64e0c2596ada4f5a5ea17121
ToppCellfacs-Kidney-nan-24m-Lymphocytic-B_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CXCR5 ACER1 SCD SCN4A

2.80e-041678443c4183a8225bae37b9f5341ebd1b95409ced2022
ComputationalGenes in the cancer module 73.

CXCR5 IL10RA TLR1

1.57e-0423503MODULE_73
ComputationalCaner module 265: IL receptors.

CXCR5 IL10RA TLR1

3.18e-0429503MODULE_265
DrugTiabendazole [148-79-8]; Down 200; 19.8uM; PC3; HT_HG-U133A

ZMYND11 NPR3 BTG2 CLCN4 SCN8A UGT8 CA5B SOS2

7.03e-071988484579_DN
DiseaseHYPOKALEMIC PERIODIC PARALYSIS, TYPE 1

CACNA1S SCN4A

7.63e-062822170400
DiseaseHypokalemic periodic paralysis, type 1

CACNA1S SCN4A

7.63e-062822cv:C3714580
DiseaseHypokalemic periodic paralysis

CACNA1S SCN4A

7.63e-062822cv:C0238358
DiseaseHypokalemic periodic paralysis type 1

CACNA1S SCN4A

2.28e-053822C3714580
Diseaseanti-Helicobacter pylori serum IgG measurement

TLR10 TLR1

2.28e-053822EFO_0005247
DiseaseHypokalemic periodic paralysis

CACNA1S SCN4A

4.56e-054822C0238358
Diseaseamino acid measurement

SCN4A SHPRH ZBTB40 LRP2 GRB14 COL14A1 C5 BCAM CMAHP

1.11e-04678829EFO_0005134
Diseaseasymmetrical dimethylarginine measurement

ZFAT LOXL4

2.11e-048822EFO_0006522
Diseaseaspergillosis (is_implicated_in)

TLR1 TLR6

2.11e-048822DOID:13564 (is_implicated_in)
Diseasehypokalemic periodic paralysis (implicated_via_orthology)

CACNA1S SCN4A

2.11e-048822DOID:14452 (implicated_via_orthology)
DiseaseIntellectual Disability

ZMYND11 RTTN SCN8A ZBTB40 LRP2 SERAC1 STT3B

2.50e-04447827C3714756
Diseaseend stage renal disease (biomarker_via_orthology)

KL LRP2 ADIPOR2

3.07e-0447823DOID:783 (biomarker_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN4A SCN8A

3.38e-0410822DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN4A SCN8A

3.38e-0410822DOID:0080422 (implicated_via_orthology)
Diseaseautoimmune thyroiditis (is_implicated_in)

ZFAT LRP2

4.94e-0412822DOID:7188 (is_implicated_in)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN4A SCN8A

4.94e-0412822DOID:0060170 (implicated_via_orthology)
DiseaseCongenital myopathy (disorder)

CACNA1S SCN4A

4.94e-0412822C0270960
Diseasehyperinsulinism (biomarker_via_orthology)

SCD ADIPOR2

7.82e-0415822DOID:2018 (biomarker_via_orthology)
Diseaseasthma (is_implicated_in)

TLR10 TLR1 C5 TLR6

9.77e-04157824DOID:2841 (is_implicated_in)
Diseaseperinatal necrotizing enterocolitis (biomarker_via_orthology)

TLR1 TLR6

1.01e-0317822DOID:8677 (biomarker_via_orthology)
DiseaseNoonan-Like Syndrome With Loose Anagen Hair

SOS1 SOS2

1.27e-0319822C3501846
DiseaseCostello syndrome (disorder)

SOS1 SOS2

1.27e-0319822C0587248
DiseaseNoonan syndrome-like disorder with loose anagen hair

SOS1 SOS2

1.27e-0319822C1843181
DiseaseCardio-facio-cutaneous syndrome

SOS1 SOS2

1.27e-0319822C1275081
Diseaseasthma, allergic disease

TLR10 TLR1 TLR6

1.40e-0379823MONDO_0004979, MONDO_0005271
DiseaseNonsyndromic Deafness

MYO1F ELMOD3 CEMIP

1.51e-0381823C3711374
DiseaseLEOPARD Syndrome

SOS1 SOS2

1.70e-0322822C0175704
DiseaseNoonan Syndrome

SOS1 SOS2

2.02e-0324822C0028326
DiseaseHbA1c measurement

KL ZFAT CLASP1 GRB14 CMAHP SOS1 SOS2

2.74e-03675827EFO_0004541
Diseasetuberculosis (is_implicated_in)

TLR1 TLR6

2.75e-0328822DOID:399 (is_implicated_in)
Diseasecorpus callosum volume measurement

EEF1AKMT2 MOB2 SOS1

2.76e-03100823EFO_0010299

Protein segments in the cluster

PeptideGeneStartEntry
AADAFALLHWALHVY

EXOC3L1

331

Q86VI1
HARVISAFFSYWITH

ERICH1

421

Q86X53
EHNYRLKQFHFHWGA

CA5B

121

Q9Y2D0
SFYAATFLHLAHVWR

ELMOD3

286

Q96FG2
IYRNHFWKEHHFEGI

AKR7L

231

Q8NHP1
ETHAWFTSRFLYHVA

CXCR5

211

P32302
FWQRIHFFYLHSIWH

ACER1

196

Q8TDN7
HFFYLHSIWHVLISI

ACER1

201

Q8TDN7
GVEQLAYHHHDWIIF

CLCN4

486

P51793
AYHHHDWIIFRNWCR

CLCN4

491

P51793
HFFHLWNDFAYIEVD

CEMIP

1221

Q8WUJ3
HYHVVKWHYNEQSLH

ARMC12

266

Q5T9G4
LFRHHHWSRAALVYS

NPR3

191

P17342
CDIWFHSHQLFHIFV

ADIPOR2

341

Q86V24
LPFQIYYHCNRHHWV

P2RY8

76

Q86VZ1
LFHVLAHIYWAHFKE

MOB2

151

Q70IA6
RLHVAWFYIHGVFYH

PEX10

176

O60683
CIIHYRHQEFSHWLH

KIAA0100

376

Q14667
VWHQCHRHYHSIEVF

LOXL4

606

Q96JB6
FNSHVHVEYEWRLLH

ASAP2

681

O43150
WHFTHSHYNATIYEN

FAT2

31

Q9NYQ8
FHFRHARENLHWDGV

PCED1B

216

Q96HM7
VAWKHYFHQHYPQLH

GNL1

236

P36915
SVWFEAEFFHHILHW

IL10RA

31

Q13651
AVGVAFHYHLQRVFW

LRP2

426

P98164
FHYHLQRVFWTDTVQ

LRP2

431

P98164
LLHSYFYLRHWHLNQ

PGAP4

46

Q9BRR3
LAQLYHHWGSVDSHF

OGG1

106

O15527
AIWHLFVATAAAVHY

MMD

206

Q15546
HRVHFHLPYRWQFLD

PARP12

291

Q9H0J9
VFYIHFNVHWDRNDT

HERC5

831

Q9UII4
AIFWFHAHEIQYHAC

OR52R1

86

Q8NGF1
ENHYRLKQFHFHWGA

CA5A

121

P35218
CHIYHHALHSRWYQA

EIF3C

571

Q99613
GLYDHFNATFWRHVA

GAL3ST3

296

Q96A11
LCHIYHHALHSRWYQ

EIF3CL

571

B5ME19
YVSFEDRHWHHNCFS

FHL3

236

Q13643
RHREWVHSDFHFDNV

CACNA1S

986

Q13698
CAHWQVHRHATAYRV

COL14A1

936

Q05707
QLHCHNFSWYLHNVY

GALNT6

471

Q8NCL4
HYYHRHTRSIFWELQ

DHCR24

326

Q15392
HHHAWIIFVFLAETR

EEF1AKMT2

241

Q5JPI9
HHRWYLCHFGQSLIH

SLC31A2

86

O15432
VFHYLETGNHWNIFH

C5

1021

P01031
YWIDYIIRHNGAHHL

UGT8

446

Q16880
LYACFHRDSWHLRHQ

CNTFR

86

P26992
WITFNVGYHVEHHDF

DEGS2

251

Q6QHC5
HSYELFNRRWHGHVL

HEPN1

61

Q6WQI6
AHALAWHVYNEKFRH

KL

706

Q9UEF7
NHYIDDHSWTLFEHL

GRB14

141

Q14449
WLIHRFHIHLYNQDS

HEATR1

116

Q9H583
HTIIRQHLDYGHWYD

DNAH9

2561

Q9NYC9
FHLTLHYPTEHVQFW

BCAM

256

P50895
SAFEAWYIHEHVERH

MFSD5

146

Q6N075
HLDHWLRYFPLSHFL

HS3ST6

231

Q96QI5
WFNHLYNHEDIIQTH

RUSC2

1121

Q8N2Y8
ELISAFYHTWTHLFN

RTTN

1731

Q86VV8
SETHHWHDYQYRIIA

SERAC1

156

Q96JX3
RILNVFRHWVEHHFY

SOS2

686

Q07890
FRHWVEHHFYDFERD

SOS2

691

Q07890
RWHMHDFFHSFLIVF

SCN4A

741

P35499
TLWCHRRHIFYLQHH

PTAR1

311

Q7Z6K3
VQNEWCHYEFYFAHH

TLR10

701

Q9BXR5
WEHRDVHNIYGLYVH

GANAB

566

Q14697
NHAHWGRHIVSFFLI

SLC36A2

141

Q495M3
FFKYIHDRWTEHHGR

ST3GAL2

261

Q16842
IHWLHFSPVERHFYH

SHPRH

921

Q149N8
NVCRHWVEHHFYDFE

SOS1

691

Q07889
HIVAHFFNLERYHWS

NOX3

116

Q9HBY0
RVYYDEAIHSIDWHH

STXBP5L

246

Q9Y2K9
WCHYELYFAHHNLFH

TLR1

706

Q15399
ALQEALTEHYKHHWF

BTG2

41

P78543
RDPDIYHHLFWNHFQ

CMAHP

441

Q9Y471
HLHTHFGADYDWFFI

CHPF2

166

Q9P2E5
WGFHSHFSREAEHLY

CLASP1

511

Q7Z460
FWYQVHFDMHVRTHT

ZFAT

751

Q9P243
HALYLAENHAHHEWY

VPS11

501

Q9H270
SQHIADTHFSDHLYW

ZNF639

276

Q9UID6
THHLASHGFYEFLNW

STT3B

111

Q8TCJ2
RHYRNPWKAAYHHFQ

SAP130

901

Q9H0E3
RWHMHDFFHSFLIVF

SCN8A

916

Q9UQD0
YEWARDHRAHHKFSE

SCD

151

O00767
WCHYELYFAHHNLFH

TLR6

711

Q9Y2C9
VDVRFFGHHHQRAWI

ZMYND11

306

Q15326
HRPYTCFHWHFVNQR

UNK

56

Q9C0B0
LWYHNRTHHPDVFAA

ZBTB40

1021

Q9NUA8
WSSHYQYHLRQHTGE

ZNF628

131

Q5EBL2
EHFNSWSAGFVIHHY

MYO1F

491

O00160
FHVWARLVDLHTVHF

NAT8B

201

Q9UHF3