Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionG protein-coupled photoreceptor activity

OPN1LW OPN1MW OPN1MW2 OPN1MW3

7.75e-07151004GO:0008020
GeneOntologyMolecularFunctionphotoreceptor activity

OPN1LW OPN1MW OPN1MW2 OPN1MW3

1.34e-06171004GO:0009881
GeneOntologyMolecularFunctionpotassium:chloride symporter activity

SLC12A4 SLC12A9 SLC12A7

1.00e-0591003GO:0015379
GeneOntologyMolecularFunctionmonoatomic anion transmembrane transporter activity

BEST1 SLC12A4 SLC12A9 LRRC8B SLC12A7 APOL2

1.12e-041511006GO:0008509
GeneOntologyMolecularFunctionSUMO ligase activity

RGPD4 RGPD8 RGPD3

1.31e-04201003GO:0061665
GeneOntologyMolecularFunctionchloride:monoatomic cation symporter activity

SLC12A4 SLC12A9 SLC12A7

2.01e-04231003GO:0015377
GeneOntologyMolecularFunctioninorganic anion transmembrane transporter activity

BEST1 ABCC4 SLC12A4 SLC12A9 SLC12A7 APOL2

2.21e-041711006GO:0015103
GeneOntologyMolecularFunctionN-formyl peptide receptor activity

GPR32 GPR32P1

2.46e-0451002GO:0004982
GeneOntologyMolecularFunctionmonoatomic anion:monoatomic cation symporter activity

SLC12A4 SLC12A9 SLC12A7

2.91e-04261003GO:0015296
GeneOntologyMolecularFunctionchannel activity

BEST1 TRPV1 TPTE2 TRPM2 GRIN2D SLC12A4 KCNK3 LRRC8B SLC12A7 APOL2

3.02e-0452510010GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

BEST1 TRPV1 TPTE2 TRPM2 GRIN2D SLC12A4 KCNK3 LRRC8B SLC12A7 APOL2

3.06e-0452610010GO:0022803
GeneOntologyMolecularFunctionchloride transmembrane transporter activity

BEST1 SLC12A4 SLC12A9 SLC12A7 APOL2

4.15e-041251005GO:0015108
GeneOntologyMolecularFunctionligand-gated calcium channel activity

TRPV1 TRPM2 GRIN2D

4.95e-04311003GO:0099604
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

BEST1 TRPV1 TPTE2 TRPM2 GRIN2D SLC12A4 SLC12A9 KCNK3 LRRC8B UQCRFS1 SLC12A7 APOL2

6.04e-0479310012GO:0015075
GeneOntologyMolecularFunctionSUMO transferase activity

RGPD4 RGPD8 RGPD3

7.72e-04361003GO:0019789
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

EPOR TRPV1 CRLF1 GPR32 GPR32P1 OPN1LW GRIN2D OPN1MW AR OPN1MW2 OPN1MW3 P2RY6 RXFP2 ROS1 NOTCH1 NOTCH2

1.09e-03135310016GO:0004888
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

BEST1 ABCC4 TRPV1 TRPM2 GRIN2D SLC12A4 SLC12A9 KCNK3 UQCRFS1 SLC12A7 APOL2

1.44e-0375810011GO:0015318
GeneOntologyMolecularFunctionammonium channel activity

SLC12A4 SLC12A7

1.59e-03121002GO:0008519
GeneOntologyMolecularFunctionpeptidyl-prolyl cis-trans isomerase activity

RGPD4 RGPD8 RGPD3

2.01e-03501003GO:0003755
GeneOntologyMolecularFunctionmonoatomic ion channel activity

BEST1 TRPV1 TPTE2 TRPM2 GRIN2D KCNK3 LRRC8B APOL2

2.16e-034591008GO:0005216
GeneOntologyMolecularFunctioncomplement receptor activity

GPR32 GPR32P1

2.17e-03141002GO:0004875
GeneOntologyMolecularFunctionglutamate binding

GRIN2D CPS1

2.17e-03141002GO:0016595
GeneOntologyMolecularFunctioncis-trans isomerase activity

RGPD4 RGPD8 RGPD3

2.38e-03531003GO:0016859
GeneOntologyBiologicalProcessNLS-bearing protein import into nucleus

RGPD4 RGPD8 RGPD3 RGPD5

2.28e-0620994GO:0006607
GeneOntologyBiologicalProcessdetection of visible light

BEST1 OPN1LW OPN1MW OPN1MW2 OPN1MW3

7.90e-0657995GO:0009584
GeneOntologyBiologicalProcesspositive regulation of glucokinase activity

RGPD4 RGPD8 RGPD3

8.82e-069993GO:0033133
GeneOntologyBiologicalProcessmonoatomic anion homeostasis

CPS1 SLC12A4 SLC12A9 SLC12A7

9.36e-0628994GO:0055081
GeneOntologyBiologicalProcesspositive regulation of hexokinase activity

RGPD4 RGPD8 RGPD3

1.26e-0510993GO:1903301
GeneOntologyBiologicalProcessdetection of external stimulus

BEST1 TRPV1 OPN1LW GRIN2D OPN1MW OPN1MW2 OPN1MW3

2.01e-05173997GO:0009581
GeneOntologyBiologicalProcessdetection of abiotic stimulus

BEST1 TRPV1 OPN1LW GRIN2D OPN1MW OPN1MW2 OPN1MW3

2.17e-05175997GO:0009582
GeneOntologyBiologicalProcesspancreas regeneration

REG1A REG1B

2.28e-052992GO:1990798
GeneOntologyBiologicalProcessmonoatomic anion transport

BEST1 ABCC4 SLC12A4 SLC12A9 P2RY6 LRRC8B SLC12A7

2.89e-05183997GO:0006820
GeneOntologyBiologicalProcessregulation of glucokinase activity

RGPD4 RGPD8 RGPD3

2.96e-0513993GO:0033131
GeneOntologyBiologicalProcessdetection of light stimulus

BEST1 OPN1LW OPN1MW OPN1MW2 OPN1MW3

3.46e-0577995GO:0009583
GeneOntologyBiologicalProcessregulation of hexokinase activity

RGPD4 RGPD8 RGPD3

3.76e-0514993GO:1903299
GeneOntologyBiologicalProcesscellular response to tumor cell

NOTCH1 NOTCH2

6.82e-053992GO:0071228
GeneOntologyBiologicalProcesspositive regulation of acinar cell proliferation

REG1A REG1B

6.82e-053992GO:1904699
GeneOntologyBiologicalProcessmonoatomic anion transmembrane transport

BEST1 ABCC4 SLC12A4 SLC12A9 LRRC8B SLC12A7

9.59e-05153996GO:0098656
GeneOntologyBiologicalProcessphototransduction

OPN1LW OPN1MW OPN1MW2 OPN1MW3

1.22e-0453994GO:0007602
GeneOntologyBiologicalProcessammonium import across plasma membrane

SLC12A4 SLC12A7

1.36e-044992GO:0140157
GeneOntologyBiologicalProcessregulation of acinar cell proliferation

REG1A REG1B

2.26e-045992GO:1904697
GeneOntologyBiologicalProcessacinar cell proliferation

REG1A REG1B

2.26e-045992GO:1990863
GeneOntologyBiologicalProcesscellular response to temperature stimulus

TRPV1 TRPM2

2.26e-045992GO:0071502
GeneOntologyBiologicalProcesschloride ion homeostasis

SLC12A4 SLC12A9 SLC12A7

2.28e-0425993GO:0055064
GeneOntologyBiologicalProcessinorganic anion transport

BEST1 SLC12A4 SLC12A9 P2RY6 ROS1 SLC12A7

2.33e-04180996GO:0015698
GeneOntologyBiologicalProcesspositive regulation of response to oxidative stress

EPOR TRPM2

3.38e-046992GO:1902884
GeneOntologyBiologicalProcesshair follicle maturation

TRPV1 ERCC2 NOTCH1

3.58e-0429993GO:0048820
GeneOntologyBiologicalProcesschloride transport

BEST1 SLC12A4 SLC12A9 P2RY6 SLC12A7

3.82e-04128995GO:0006821
GeneOntologyBiologicalProcessmyelination

GPC1 ERCC2 NAB1 REG1A REG1B SBF2

4.78e-04206996GO:0042552
GeneOntologyBiologicalProcessaxon ensheathment

GPC1 ERCC2 NAB1 REG1A REG1B SBF2

5.16e-04209996GO:0008366
GeneOntologyBiologicalProcessensheathment of neurons

GPC1 ERCC2 NAB1 REG1A REG1B SBF2

5.16e-04209996GO:0007272
GeneOntologyCellularComponentcytoplasmic periphery of the nuclear pore complex

RGPD4 RGPD8 RGPD3

5.33e-068973GO:1990723
GeneOntologyCellularComponentphotoreceptor disc membrane

OPN1LW OPN1MW OPN1MW2 OPN1MW3

6.02e-0626974GO:0097381
GeneOntologyCellularComponentnuclear pore cytoplasmic filaments

RGPD4 RGPD8 RGPD3

1.14e-0510973GO:0044614
GeneOntologyCellularComponentannulate lamellae

RGPD4 RGPD8 RGPD3

3.40e-0514973GO:0005642
GeneOntologyCellularComponentnuclear pore nuclear basket

RGPD4 RGPD8 RGPD3

7.51e-0518973GO:0044615
GeneOntologyCellularComponentnuclear inclusion body

RGPD4 RGPD8 RGPD3

1.04e-0420973GO:0042405
GeneOntologyCellularComponentSUMO ligase complex

RGPD4 RGPD8 RGPD3

1.21e-0421973GO:0106068
GeneOntologyCellularComponentnon-motile cilium

MDM1 OPN1LW OPN1MW NPHP4 OPN1MW2 OPN1MW3

3.06e-04196976GO:0097730
GeneOntologyCellularComponentphotoreceptor cell cilium

OPN1LW OPN1MW NPHP4 OPN1MW2 OPN1MW3

4.77e-04139975GO:0097733
GeneOntologyCellularComponent9+0 non-motile cilium

OPN1LW OPN1MW NPHP4 OPN1MW2 OPN1MW3

7.38e-04153975GO:0097731
GeneOntologyCellularComponentnuclear envelope

RGPD4 RGPD8 TOR2A FANCL RIF1 INTS5 RGPD3 OSBPL8 RGPD5

1.18e-03560979GO:0005635
GeneOntologyCellularComponentnuclear pore

RGPD4 RGPD8 RGPD3 RGPD5

1.26e-03101974GO:0005643
GeneOntologyCellularComponentphotoreceptor outer segment

OPN1LW OPN1MW OPN1MW2 OPN1MW3

1.79e-03111974GO:0001750
GeneOntologyCellularComponentFanconi anaemia nuclear complex

FANCL FANCB

2.15e-0315972GO:0043240
GeneOntologyCellularComponentdendrite membrane

TRPV1 REG1A REG1B

2.25e-0356973GO:0032590
GeneOntologyCellularComponentcilium

ABCC4 MDM1 OPN1LW OPN1MW NPHP4 TTLL8 CDK10 OPN1MW2 OPN1MW3 MROH2B NOTCH2

2.96e-038989711GO:0005929
GeneOntologyCellularComponentnuclear outer membrane-endoplasmic reticulum membrane network

RGPD4 GALNT1 RGPD8 CYP4B1 TPTE2 GRIN2D RGPD3 OSBPL8 CYP4X1 HSD3B1 LRRC8B APOL2 NOTCH1 NOTCH2

3.19e-0313279714GO:0042175
HumanPhenoBlue cone monochromacy

OPN1LW OPN1MW

4.07e-052332HP:0007939
HumanPhenoCone monochromacy

OPN1LW OPN1MW

4.07e-052332HP:0011517
MousePhenodecreased tumor latency

RGPD4 ERCC2 RGPD8 RGPD3

2.68e-0530824MP:0010308
MousePhenoabnormal tumor latency

RGPD4 ERCC2 RGPD8 RGPD3

4.46e-0534824MP:0010307
MousePhenoabnormal eye physiology

RGPD4 EPOR BEST1 RGPD8 SH3BP2 MDM1 OPN1LW NPHP4 FAM151B OPN1MW2 OPN1MW3 RGPD3 HSD3B1

4.77e-056068213MP:0005253
MousePhenoelevated level of mitotic sister chromatid exchange

RGPD4 RGPD8 RGPD3

1.03e-0416823MP:0003701
DomainOpsin_red/grn

OPN1LW OPN1MW OPN1MW3

1.27e-073953IPR000378
DomainGrip

RGPD4 RGPD8 RGPD3 RGPD5

2.02e-0711954SM00755
DomainGRIP

RGPD4 RGPD8 RGPD3 RGPD5

2.02e-0711954PF01465
DomainRan_BP1

RGPD4 RGPD8 RGPD3 RGPD5

3.01e-0712954PF00638
DomainGRIP_dom

RGPD4 RGPD8 RGPD3 RGPD5

3.01e-0712954IPR000237
DomainGRIP

RGPD4 RGPD8 RGPD3 RGPD5

3.01e-0712954PS50913
DomainRANBD1

RGPD4 RGPD8 RGPD3 RGPD5

3.01e-0712954PS50196
DomainRanBD

RGPD4 RGPD8 RGPD3 RGPD5

4.34e-0713954SM00160
DomainRan_bind_dom

RGPD4 RGPD8 RGPD3 RGPD5

4.34e-0713954IPR000156
DomainGCC2_Rab_bind

RGPD4 RGPD8 RGPD3

4.40e-067953IPR032023
DomainRab_bind

RGPD4 RGPD8 RGPD3

4.40e-067953PF16704
DomainSLC12_C

SLC12A4 SLC12A9 SLC12A7

7.01e-068953IPR018491
DomainSLC12

SLC12A4 SLC12A9 SLC12A7

7.01e-068953PF03522
DomainPH_dom-like

RGPD4 RGPD8 SH3BP2 SBF2 RGPD3 OSBPL8 ARHGAP21 EPB41L1 EPB41L2 FRMD3 RGPD5

1.07e-054269511IPR011993
DomainOPSIN

OPN1LW OPN1MW OPN1MW3

1.49e-0510953PS00238
Domain-

RGPD4 RGPD8 RGPD3

1.49e-05109531.10.220.60
DomainOpsin

OPN1LW OPN1MW OPN1MW3

2.04e-0511953IPR001760
Domain-

RGPD4 RGPD8 SH3BP2 SBF2 RGPD3 OSBPL8 ARHGAP21 EPB41L1 EPB41L2 FRMD3

2.99e-0539195102.30.29.30
DomainFERM-adjacent

EPB41L1 EPB41L2 FRMD3

3.51e-0513953IPR014847
DomainFA

EPB41L1 EPB41L2 FRMD3

3.51e-0513953SM01195
DomainFA

EPB41L1 EPB41L2 FRMD3

3.51e-0513953PF08736
DomainDUF3454

NOTCH1 NOTCH2

7.65e-053952PF11936
DomainDUF3454_notch

NOTCH1 NOTCH2

7.65e-053952IPR024600
DomainDUF3454

NOTCH1 NOTCH2

7.65e-053952SM01334
DomainNotch

NOTCH1 NOTCH2

1.53e-044952IPR008297
DomainNODP

NOTCH1 NOTCH2

1.53e-044952PF07684
DomainNotch_NODP_dom

NOTCH1 NOTCH2

1.53e-044952IPR011656
DomainBand_4.1_C

EPB41L1 EPB41L2

1.53e-044952IPR008379
DomainNotch_NOD_dom

NOTCH1 NOTCH2

1.53e-044952IPR010660
Domain4_1_CTD

EPB41L1 EPB41L2

1.53e-044952PF05902
DomainSAB_dom

EPB41L1 EPB41L2

1.53e-044952IPR007477
DomainNOD

NOTCH1 NOTCH2

1.53e-044952PF06816
DomainKCL_cotranspt

SLC12A4 SLC12A7

1.53e-044952IPR000076
DomainSAB

EPB41L1 EPB41L2

1.53e-044952PF04382
DomainNOD

NOTCH1 NOTCH2

1.53e-044952SM01338
DomainNODP

NOTCH1 NOTCH2

1.53e-044952SM01339
DomainEz/rad/moesin-like

EPB41L1 EPB41L2 FRMD3

1.59e-0421953IPR000798
DomainAA-permease/SLC12A_dom

SLC12A4 SLC12A9 SLC12A7

1.83e-0422953IPR004841
DomainAA_permease

SLC12A4 SLC12A9 SLC12A7

1.83e-0422953PF00324
DomainFERM_CS

EPB41L1 EPB41L2 FRMD3

2.39e-0424953IPR019747
DomainLNR

NOTCH1 NOTCH2

2.53e-045952PS50258
DomainGrowth/epo_recpt_lig-bind

EPOR CRLF1

2.53e-045952IPR015152
DomainEpoR_lig-bind

EPOR CRLF1

2.53e-045952PF09067
DomainFERM_C

EPB41L1 EPB41L2 FRMD3

3.04e-0426953PF09380
DomainFERM_C

EPB41L1 EPB41L2 FRMD3

3.41e-0427953SM01196
DomainFERM_PH-like_C

EPB41L1 EPB41L2 FRMD3

3.41e-0427953IPR018980
DomainhEGF

MEGF11 NOTCH1 NOTCH2

3.81e-0428953PF12661
DomainSLC12A_fam

SLC12A4 SLC12A7

5.29e-047952IPR004842
DomainNotch_dom

NOTCH1 NOTCH2

5.29e-047952IPR000800
DomainNotch

NOTCH1 NOTCH2

5.29e-047952PF00066
DomainNL

NOTCH1 NOTCH2

5.29e-047952SM00004
DomainFERM_N

EPB41L1 EPB41L2 FRMD3

6.23e-0433953PF09379
DomainFERM_N

EPB41L1 EPB41L2 FRMD3

6.23e-0433953IPR018979
DomainC_TYPE_LECTIN_1

REG1A REG1B MRC2 CLEC2A

7.39e-0480954PS00615
DomainLectin_C

REG1A REG1B MRC2 CLEC2A

8.88e-0484954PF00059
DomainCLECT

REG1A REG1B MRC2 CLEC2A

8.88e-0484954SM00034
DomainC_TYPE_LECTIN_2

REG1A REG1B MRC2 CLEC2A

9.28e-0485954PS50041
DomainC-type_lectin-like

REG1A REG1B MRC2 CLEC2A

9.70e-0486954IPR001304
DomainTPR-contain_dom

RGPD4 RGPD8 TRANK1 RGPD3 RGPD5

1.01e-03150955IPR013026
DomainC-type_lectin_CS

REG1A REG1B MRC2

1.36e-0343953IPR018378
Domain-

REG1A REG1B MRC2 CLEC2A

1.52e-03979543.10.100.10
DomainTPR_REGION

RGPD4 RGPD8 TRANK1 RGPD3 RGPD5

1.55e-03165955PS50293
DomainTPR

RGPD4 RGPD8 TRANK1 RGPD3 RGPD5

1.55e-03165955PS50005
DomainC-type_lectin-like/link

REG1A REG1B MRC2 CLEC2A

1.63e-0399954IPR016186
DomainFERM_M

EPB41L1 EPB41L2 FRMD3

1.65e-0346953PF00373
Domain-

EPB41L1 EPB41L2 FRMD3

1.98e-03499531.20.80.10
DomainFERM_central

EPB41L1 EPB41L2 FRMD3

1.98e-0349953IPR019748
DomainFERM_domain

EPB41L1 EPB41L2 FRMD3

1.98e-0349953IPR000299
DomainFERM_1

EPB41L1 EPB41L2 FRMD3

2.10e-0350953PS00660
DomainFERM_2

EPB41L1 EPB41L2 FRMD3

2.10e-0350953PS00661
DomainFERM_3

EPB41L1 EPB41L2 FRMD3

2.10e-0350953PS50057
DomainBand_41_domain

EPB41L1 EPB41L2 FRMD3

2.10e-0350953IPR019749
DomainB41

EPB41L1 EPB41L2 FRMD3

2.10e-0350953SM00295
DomainFERM/acyl-CoA-bd_prot_3-hlx

EPB41L1 EPB41L2 FRMD3

2.10e-0350953IPR014352
DomainCTDL_fold

REG1A REG1B MRC2 CLEC2A

2.17e-03107954IPR016187
DomainTPR

RGPD4 RGPD8 TRANK1 RGPD3

4.26e-03129954SM00028
DomainTPR_repeat

RGPD4 RGPD8 TRANK1 RGPD3

4.75e-03133954IPR019734
PathwayREACTOME_THE_RETINOID_CYCLE_IN_CONES_DAYLIGHT_VISION

OPN1LW OPN1MW2 OPN1MW3

7.63e-068743MM14880
PathwayREACTOME_OPSINS

OPN1LW OPN1MW2 OPN1MW3

1.62e-0510743MM15063
PathwayBIOCARTA_RANBP2_PATHWAY

RGPD4 RGPD8 RGPD3

1.07e-0418743MM1549
Pubmed

Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.

RGPD4 RGPD8 OPN1LW OPN1MW OPN1MW2 RGPD3

1.01e-131010068857542
Pubmed

Human L- and M-opsins restore M-cone function in a mouse model for human blue cone monochromacy.

OPN1LW OPN1MW OPN1MW2 OPN1MW3

6.43e-114100429386880
Pubmed

Molecular genetics of human color vision: the genes encoding blue, green, and red pigments.

OPN1LW OPN1MW OPN1MW2 OPN1MW3

3.21e-10510042937147
Pubmed

Complex genomic rearrangements lead to novel primate gene function.

RGPD4 RGPD8 RGPD3 RGPD5

2.24e-097100415710750
Pubmed

Fam151b, the mouse homologue of C.elegans menorin gene, is essential for retinal function.

OPN1LW FAM151B OPN1MW2 OPN1MW3

1.33e-0810100431949211
Pubmed

Multiple hypothalamic cell populations encoding distinct visual information.

OPN1LW OPN1MW2 OPN1MW3

2.31e-083100321224225
Pubmed

Circadian Regulation of the Rod Contribution to Mesopic Vision in Mice.

OPN1LW OPN1MW2 OPN1MW3

2.31e-083100336216501
Pubmed

Extensive cone-dependent spectral opponency within a discrete zone of the lateral geniculate nucleus supporting mouse color vision.

OPN1LW OPN1MW2 OPN1MW3

2.31e-083100334111401
Pubmed

Gene-based Therapy in a Mouse Model of Blue Cone Monochromacy.

OPN1LW OPN1MW2 OPN1MW3

2.31e-083100328751656
Pubmed

The molecular genetics and evolution of red and green color vision in vertebrates.

OPN1LW OPN1MW2 OPN1MW3

2.31e-083100311545071
Pubmed

Co-expression of murine opsins facilitates identifying the site of cone adaptation.

OPN1LW OPN1MW2 OPN1MW3

2.31e-083100312511072
Pubmed

Molecular determinants of human red/green color discrimination.

OPN1LW OPN1MW OPN1MW2

2.31e-08310038185948
Pubmed

X-linked cone dystrophy caused by mutation of the red and green cone opsins.

OPN1LW OPN1MW OPN1MW2

2.31e-083100320579627
Pubmed

Expression of red/green-cone opsin mutants K82E, P187S, M273K result in unique pathobiological perturbations to cone structure and function.

OPN1LW OPN1MW2 OPN1MW3

2.31e-083100338410159
Pubmed

Chloride-dependent spectral tuning mechanism of L-group cone visual pigments.

OPN1LW OPN1MW2 OPN1MW3

2.31e-083100323350963
Pubmed

Distinct contributions of rod, cone, and melanopsin photoreceptors to encoding irradiance.

OPN1LW OPN1MW2 OPN1MW3

2.31e-083100320471354
Pubmed

Spectral tuning of a circadian photopigment in a subterranean 'blind' mammal (Spalax ehrenbergi).

OPN1LW OPN1MW2 OPN1MW3

2.31e-083100310567724
Pubmed

Genetically engineered mice with an additional class of cone photoreceptors: implications for the evolution of color vision.

OPN1LW OPN1MW2 OPN1MW3

2.31e-083100314500905
Pubmed

Rescue of M-cone Function in Aged Opn1mw-/- Mice, a Model for Late-Stage Blue Cone Monochromacy.

OPN1LW OPN1MW2 OPN1MW3

2.31e-083100331469404
Pubmed

Mechanisms of spectral tuning in the mouse green cone pigment.

OPN1LW OPN1MW2 OPN1MW3

2.31e-08310039238068
Pubmed

Emergence of novel color vision in mice engineered to express a human cone photopigment.

OPN1LW OPN1MW2 OPN1MW3

2.31e-083100317379811
Pubmed

The Pem homeobox gene is X-linked and exclusively expressed in extraembryonic tissues during early murine development.

OPN1LW OPN1MW2 OPN1MW3

2.31e-08310037958444
Pubmed

The Retinal Pigment Epithelium Is a Notch Signaling Niche in the Mouse Retina.

OPN1LW OPN1MW2 OPN1MW3 NOTCH1 NOTCH2

5.38e-0835100528402857
Pubmed

Modulation of Fast Narrowband Oscillations in the Mouse Retina and dLGN According to Background Light Intensity.

OPN1LW OPN1MW2 OPN1MW3

9.21e-084100328103478
Pubmed

Molecular biology of the visual pigments.

OPN1LW OPN1MW OPN1MW2

9.21e-08410033303660
Pubmed

Melanopsin-driven increases in maintained activity enhance thalamic visual response reliability across a simulated dawn.

OPN1LW OPN1MW2 OPN1MW3

9.21e-084100326438865
Pubmed

Light/dark translocation of alphatransducin in mouse photoreceptor cells expressing G90D mutant opsin.

OPN1LW OPN1MW2 OPN1MW3

9.21e-084100317249565
Pubmed

Structural and functional rescue of cones carrying the most common cone opsin C203R missense mutation.

OPN1LW OPN1MW2 OPN1MW3

9.21e-084100338060327
Pubmed

Contribution of M-opsin-based color vision to refractive development in mice.

OPN1LW OPN1MW2 OPN1MW3

9.21e-084100334126082
Pubmed

Visual responses in the dorsal lateral geniculate nucleus at early stages of retinal degeneration in rd1 PDE6β mice.

OPN1LW OPN1MW2 OPN1MW3

9.21e-084100331461375
Pubmed

Murine and bovine blue cone pigment genes: cloning and characterization of two new members of the S family of visual pigments.

OPN1LW OPN1MW2 OPN1MW3

9.21e-08410038088841
Pubmed

Cones Support Alignment to an Inconsistent World by Suppressing Mouse Circadian Responses to the Blue Colors Associated with Twilight.

OPN1LW OPN1MW2 OPN1MW3

9.21e-084100331846668
Pubmed

Physiological features of the S- and M-cone photoreceptors of wild-type mice from single-cell recordings.

OPN1LW OPN1MW2 OPN1MW3

9.21e-084100316567464
Pubmed

S-opsin knockout mice with the endogenous M-opsin gene replaced by an L-opsin variant.

OPN1LW OPN1MW2 OPN1MW3

9.21e-084100324801621
Pubmed

Melanopsin Contributions to the Representation of Images in the Early Visual System.

OPN1LW OPN1MW2 OPN1MW3

9.21e-084100328528909
Pubmed

Melanopsin-driven light adaptation in mouse vision.

OPN1LW OPN1MW2 OPN1MW3

9.21e-084100325308073
Pubmed

Using Silent Substitution to Track the Mesopic Transition From Rod- to Cone-Based Vision in Mice.

OPN1LW OPN1MW2 OPN1MW3

2.30e-075100326818794
Pubmed

A distinct contribution of short-wavelength-sensitive cones to light-evoked activity in the mouse pretectal olivary nucleus.

OPN1LW OPN1MW2 OPN1MW3

2.30e-075100322090509
Pubmed

Peripherin-2 differentially interacts with cone opsins in outer segments of cone photoreceptors.

OPN1LW OPN1MW2 OPN1MW3

2.30e-075100327033727
Pubmed

The notch receptor and its ligands are selectively expressed during hematopoietic development in the mouse.

EPOR NOTCH1 NOTCH2

2.30e-075100311713346
Pubmed

The murine cone photoreceptor: a single cone type expresses both S and M opsins with retinal spatial patterning.

OPN1LW OPN1MW2 OPN1MW3

2.30e-075100311055434
Pubmed

Noncoding Mutations in a Thyroid Hormone Receptor Gene That Impair Cone Photoreceptor Function.

OPN1LW OPN1MW2 OPN1MW3

2.30e-075100336631163
Pubmed

A common integration locus in type B retrovirus-induced thymic lymphomas.

OPN1LW OPN1MW2 OPN1MW3

2.30e-07510031333116
Pubmed

Comparative sequence analysis of the MECP2-locus in human and mouse reveals new transcribed regions.

OPN1LW OPN1MW2 OPN1MW3

2.30e-075100310723722
Pubmed

Melanopsin-based brightness discrimination in mice and humans.

OPN1LW OPN1MW2 OPN1MW3

2.30e-075100322633808
Pubmed

Enhancer/promoter activities of the long/middle wavelength-sensitive opsins of vertebrates mediated by thyroid hormone receptor β2 and COUP-TFII.

OPN1LW OPN1MW2 OPN1MW3

2.30e-075100324058409
Pubmed

Variations in photoreceptor throughput to mouse visual cortex and the unique effects on tuning.

OPN1LW OPN1MW2 OPN1MW3

2.30e-075100334099749
Pubmed

Typing recombinant inbred mouse strains for microsatellite markers on chromosomes 10, 16, 18, 19, and X.

MDM1 OPN1LW OPN1MW2 OPN1MW3

3.01e-072010048589516
Pubmed

Notch signaling controls hepatoblast differentiation by altering the expression of liver-enriched transcription factors.

CPS1 NOTCH1 NOTCH2

4.58e-076100315226394
Pubmed

Reduced levels of dystrophin associated proteins in the brains of mice deficient for Dp71.

OPN1LW OPN1MW2 OPN1MW3

4.58e-07610038872469
Pubmed

A thyroid hormone receptor that is required for the development of green cone photoreceptors.

OPN1LW OPN1MW2 OPN1MW3

4.58e-076100311138006
Pubmed

Functional comparison of rod and cone Gα(t) on the regulation of light sensitivity.

OPN1LW OPN1MW2 OPN1MW3

4.58e-076100323288843
Pubmed

Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase.

OPN1LW OPN1MW2 OPN1MW3

4.58e-076100310395695
Pubmed

Transient expression of thyroid hormone nuclear receptor TRbeta2 sets S opsin patterning during cone photoreceptor genesis.

OPN1LW OPN1MW2 OPN1MW3

4.58e-076100317436273
Pubmed

Telomere-related markers for the pseudoautosomal region of the mouse genome.

OPN1LW OPN1MW2 OPN1MW3

4.58e-07610031549575
Pubmed

Notch 1 inhibits photoreceptor production in the developing mammalian retina.

OPN1LW OPN1MW2 OPN1MW3 NOTCH1

7.77e-0725100416452096
Pubmed

DNA segments mapped by reciprocal use of microsatellite primers between mouse and rat.

OPN1LW AR OPN1MW2 OPN1MW3

7.77e-072510048268655
Pubmed

Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.

RGPD4 RGPD8 RGPD3

8.01e-07710039037092
Pubmed

NeuroD1 regulates expression of thyroid hormone receptor 2 and cone opsins in the developing mouse retina.

OPN1LW OPN1MW2 OPN1MW3

8.01e-077100318199774
Pubmed

Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.

RGPD4 RGPD8 RGPD3

8.01e-077100311353387
Pubmed

Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.

RGPD4 RGPD8 RGPD3

8.01e-077100330944974
Pubmed

Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation.

RGPD4 RGPD8 RGPD3

8.01e-077100338838144
Pubmed

Characterization of cDNAs encoding the murine interleukin 2 receptor (IL-2R) gamma chain: chromosomal mapping and tissue specificity of IL-2R gamma chain expression.

OPN1LW OPN1MW2 OPN1MW3

8.01e-07710038378320
Pubmed

Rod Photoreceptor Activation Alone Defines the Release of Dopamine in the Retina.

OPN1LW OPN1MW2 OPN1MW3

8.01e-077100330799247
Pubmed

Retina-specifically expressed novel subtypes of bovine cyclophilin.

RGPD4 RGPD8 RGPD3

8.01e-07710037559465
Pubmed

Activation of the blue opsin gene in cone photoreceptor development by retinoid-related orphan receptor beta.

OPN1LW OPN1MW2 OPN1MW3

8.01e-077100316574740
Pubmed

Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.

RGPD4 RGPD8 RGPD3

8.01e-077100317372272
Pubmed

Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain.

RGPD4 RGPD8 RGPD3

8.01e-077100338657106
Pubmed

Cloning and distribution of myosin 3B in the mouse retina: differential distribution in cone outer segments.

OPN1LW OPN1MW2 OPN1MW3

8.01e-077100319332056
Pubmed

Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis.

RGPD4 RGPD8 RGPD3

8.01e-077100321205196
Pubmed

Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.

RGPD4 RGPD8 RGPD3

8.01e-077100318949001
Pubmed

Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.

RGPD4 RGPD8 RGPD3

8.01e-077100325187515
Pubmed

Retarded developmental expression and patterning of retinal cone opsins in hypothyroid mice.

OPN1LW OPN1MW2 OPN1MW3

8.01e-077100318974269
Pubmed

Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.

RGPD4 RGPD8 RGPD3

8.01e-07710038603673
Pubmed

Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).

RGPD4 RGPD8 RGPD3

8.01e-077100326632511
Pubmed

Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.

RGPD4 RGPD8 RGPD3

8.01e-077100324403063
Pubmed

Genetic and physical mapping of a gene encoding a methyl CpG binding protein, Mecp2, to the mouse X chromosome.

OPN1LW OPN1MW2 OPN1MW3

8.01e-07710038001979
Pubmed

Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.

RGPD4 RGPD8 RGPD3

8.01e-077100323818861
Pubmed

Mapping of the murine tbl1 gene reveals a new rearrangement between mouse and human X Chromosomes.

OPN1LW OPN1MW2 OPN1MW3

8.01e-07710039880679
Pubmed

Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.

RGPD4 RGPD8 RGPD3

8.01e-077100323536549
Pubmed

Rods progressively escape saturation to drive visual responses in daylight conditions.

OPN1LW OPN1MW2 OPN1MW3

8.01e-077100329180667
Pubmed

Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization.

RGPD4 RGPD8 RGPD3

8.01e-077100312191015
Pubmed

Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

RGPD4 RGPD8 RGPD3

8.01e-077100322821000
Pubmed

Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.

RGPD4 RGPD8 RGPD3

8.01e-077100320682751
Pubmed

Localization of the mdx mutation within the mouse dystrophin gene.

OPN1LW OPN1MW2 OPN1MW3

1.28e-06810032903046
Pubmed

The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.

RGPD4 RGPD8 RGPD3

1.28e-068100321670213
Pubmed

Genetic mapping on the mouse X chromosome of human cDNA clones for the fragile X and Hunter syndromes.

OPN1LW OPN1MW2 OPN1MW3

1.28e-06810031572654
Pubmed

Two transcription factors can direct three photoreceptor outcomes from rod precursor cells in mouse retinal development.

OPN1LW OPN1MW2 OPN1MW3

1.28e-068100321813673
Pubmed

Transcriptional profiling of murine retinas undergoing semi-synchronous cone photoreceptor differentiation.

OPN1LW OPN1MW2 OPN1MW3

1.28e-068100331163126
Pubmed

Type 3 deiodinase, a thyroid-hormone-inactivating enzyme, controls survival and maturation of cone photoreceptors.

OPN1LW OPN1MW2 OPN1MW3

1.28e-068100320203194
Pubmed

Tubby is required for trafficking G protein-coupled receptors to neuronal cilia.

OPN1LW OPN1MW2 OPN1MW3

1.28e-068100323351594
Pubmed

Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.

RGPD4 RGPD8 RGPD3

1.28e-068100327412403
Pubmed

A retinitis pigmentosa GTPase regulator (RPGR)-deficient mouse model for X-linked retinitis pigmentosa (RP3).

OPN1LW OPN1MW2 OPN1MW3

1.28e-068100310725384
Pubmed

Nr2e3 functional domain ablation by CRISPR-Cas9D10A identifies a new isoform and generates retinitis pigmentosa and enhanced S-cone syndrome models.

OPN1LW OPN1MW2 OPN1MW3

1.28e-068100333007388
Pubmed

Linkage of amelogenin (Amel) to the distal portion of the mouse X chromosome.

OPN1LW OPN1MW2 OPN1MW3

1.28e-06810031675194
Pubmed

Mice lacking Ran binding protein 1 are viable and show male infertility.

RGPD4 RGPD8 RGPD3

1.28e-068100321310149
Pubmed

The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2.

RGPD4 RGPD8 RGPD3

1.28e-068100322262462
Pubmed

X-chromosome gene order in different Mus species crosses.

OPN1LW OPN1MW2 OPN1MW3

1.28e-06810033416629
Pubmed

The retinitis pigmentosa GTPase regulator (RPGR)- interacting protein: subserving RPGR function and participating in disk morphogenesis.

OPN1LW OPN1MW2 OPN1MW3

1.28e-068100312651948
Pubmed

Zap70 and downstream RanBP2 are required for the exact timing of the meiotic cell cycle in oocytes.

RGPD4 RGPD8 RGPD3

1.28e-068100328745977
InteractionRGPD4 interactions

RGPD4 RGPD8 RGPD3 RGPD5

3.04e-0622944int:RGPD4
InteractionRXFP1 interactions

ABCC4 SRPK2 SLC12A4 SLC12A9 SLC12A7 APOL2

3.98e-0690946int:RXFP1
InteractionRGPD2 interactions

RGPD4 RGPD8 RGPD3 RGPD5

7.17e-0627944int:RGPD2
InteractionTMEM9B interactions

RNF213 RIF1 INTS5 SLC12A4 OSBPL8 NOTCH2

1.34e-05111946int:TMEM9B
InteractionCENPS interactions

RGPD8 FANCL FANCB RGPD5

2.33e-0536944int:CENPS
InteractionMS4A15 interactions

ABCC4 SLC12A4 SLC12A9 SLC12A7

3.22e-0539944int:MS4A15
InteractionLGALS9B interactions

ABCC4 SLC12A4 MRC2 SLC12A7

5.71e-0545944int:LGALS9B
InteractionRGPD3 interactions

RGPD4 RGPD8 RGPD3 RGPD5

6.79e-0547944int:RGPD3
InteractionRGPD1 interactions

RGPD4 RGPD8 RGPD3 RGPD5

8.01e-0549944int:RGPD1
CytobandEnsembl 112 genes in cytogenetic band chr1p12

WARS2 HSD3B1 NOTCH2

2.17e-04531003chr1p12
Cytoband12q14

OSBPL8 MMP19

2.55e-0411100212q14
Cytoband2q13

RGPD8 RGPD3 RGPD5

4.53e-046810032q13
Cytoband2q35

CPS1 USP37 STK16

7.03e-047910032q35
CytobandEnsembl 112 genes in cytogenetic band chrXq28

OPN1LW OPN1MW OPN1MW2 OPN1MW3

1.25e-032131004chrXq28
Cytoband19q13.33

GPR32 GPR32P1 GRIN2D

1.64e-03106100319q13.33
GeneFamilyOpsin receptors

OPN1LW OPN1MW OPN1MW2 OPN1MW3

9.81e-0811774215
GeneFamilyErythrocyte membrane protein band 4.1|FERM domain containing

EPB41L1 EPB41L2

1.07e-044772951
GeneFamilyTetratricopeptide repeat domain containing|Bardet-Biedl syndrome associated|BBSome

RGPD4 RGPD8 TRANK1 RGPD3 RGPD5

1.31e-04115775769
GeneFamilyAnkyrin repeat domain containing|FERM domain containing

EPB41L1 EPB41L2 FRMD3

1.26e-03507731293
GeneFamilyRing finger proteins|Fanconi anemia complementation groups|Protein phosphatase 1 regulatory subunits|BRCA1 A complex|BRCA1 B complex|BRCA1 C complex

FANCL FANCB

3.24e-0320772548
CoexpressionGAUSSMANN_MLL_AF4_FUSION_TARGETS_B_UP

RGPD4 CRLF1 RGPD8 RGPD3

6.64e-0633974MM477
CoexpressionTABULA_MURIS_SENIS_TRACHEA_GRANULOCYTE_AGEING

RGPD4 RGPD8 RGPD3 DCAF12

1.95e-0543974MM3857
ToppCellBAL-Mild-cDC_5|Mild / Compartment, Disease Groups and Clusters

NPHP4 FAM151B XYLT2 SLC12A7 MMP19 RGPD5

1.63e-061619967a6e8ed0b5d999efce8945d8083ab01d71be9a92
DrugLoracarbef [121961-22-6]; Down 200; 10.8uM; MCF7; HT_HG-U133A

CRLF1 NPHP4 AR STK16 XYLT2 INTS5 MMP19 EPB41L1

2.29e-061989885492_DN
Drug((2-n-butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy)acetic acid

SLC12A4 SLC12A7

1.83e-052982ctd:C095651
DrugChlortetracycline hydrochloride [64-72-2]; Up 200; 7.8uM; PC3; HG-U133A

ERCC2 SH3BP2 REG1A NPHP4 EPB41L2 NOTCH2 RAD54L

2.25e-051969871958_UP
Drugnovobiocin sodium, USP; Down 200; 100uM; ssMCF7; HG-U133A

EPOR ERCC2 CAPN10 JOSD1 MMP19 TARBP1 RAD54L

2.25e-05196987499_DN
DrugPicrotoxinin [17617-45-7]; Down 200; 13.6uM; MCF7; HT_HG-U133A

EPOR ABCC4 ERCC2 CRLF1 SH3BP2 AR MMP19

2.32e-051979874842_DN
Drug2-propylpentanoic acid; Down 200; 1000uM; ssMCF7; HG-U133A

ERCC2 SH3BP2 CDK10 P2RY6 JOSD1 MMP19 RAD54L

2.32e-05197987497_DN
Drugprochlorperazine dimaleate salt; Down 200; 10uM; MCF7; HT_HG-U133A

MDM1 NCAM2 CDK10 AR P2RY6 NOTCH1 EPB41L2

2.32e-051979876975_DN
Diseaseblue cone monochromacy (implicated_via_orthology)

OPN1LW OPN1MW OPN1MW2 OPN1MW3

9.66e-114944DOID:0050679 (implicated_via_orthology)
DiseaseBladder Neoplasm

TRPV1 ERCC2 CYP4B1 SLC12A7 NOTCH1 NOTCH2

5.92e-06140946C0005695
DiseaseMalignant neoplasm of urinary bladder

TRPV1 ERCC2 CYP4B1 SLC12A7 NOTCH1 NOTCH2

6.17e-06141946C0005684
DiseaseCone monochromatism

OPN1LW OPN1MW

1.00e-052942C0339537
DiseaseBLUE CONE MONOCHROMACY

OPN1LW OPN1MW

1.00e-052942303700
DiseaseCone monochromatism

OPN1LW OPN1MW

1.00e-052942cv:C0339537
Diseaseblue cone monochromacy (is_implicated_in)

OPN1LW OPN1MW

1.00e-052942DOID:0050679 (is_implicated_in)
DiseaseBORNHOLM EYE DISEASE

OPN1LW OPN1MW

1.00e-052942C3159311
DiseaseAchromatopsia incomplete, X-linked

OPN1LW OPN1MW

1.00e-052942C2931753
DiseaseRed-green dyschromatopsia

OPN1LW OPN1MW

1.00e-052942cv:C0155016
DiseaseNeoplasm of uncertain or unknown behavior of bladder

ERCC2 NOTCH1 NOTCH2

1.39e-0515943C0496930
DiseaseBenign neoplasm of bladder

ERCC2 NOTCH1 NOTCH2

1.39e-0515943C0154017
DiseaseCarcinoma in situ of bladder

ERCC2 NOTCH1 NOTCH2

1.39e-0515943C0154091
DiseaseCarcinoma of bladder

ERCC2 NOTCH1 NOTCH2

2.47e-0518943C0699885
DiseaseMalignant neoplasm of skin

ERCC2 ODC1 NOTCH1 NOTCH2

3.84e-0559944C0007114
DiseaseSkin Neoplasms

ERCC2 ODC1 NOTCH1 NOTCH2

3.84e-0559944C0037286
Diseasecryptorchidism (is_implicated_in)

AR RXFP2

6.00e-054942DOID:11383 (is_implicated_in)
DiseaseCerebral Astrocytoma

AR NOTCH1 NOTCH2

6.84e-0525943C0750935
DiseaseIntracranial Astrocytoma

AR NOTCH1 NOTCH2

6.84e-0525943C0750936
DiseasePilocytic Astrocytoma

AR NOTCH1 NOTCH2

6.84e-0525943C0334583
DiseaseAstrocytoma

AR NOTCH1 NOTCH2

6.84e-0525943C0004114
DiseaseJuvenile Pilocytic Astrocytoma

AR NOTCH1 NOTCH2

6.84e-0525943C0280783
DiseaseDiffuse Astrocytoma

AR NOTCH1 NOTCH2

6.84e-0525943C0280785
DiseaseGrade I Astrocytoma

AR NOTCH1 NOTCH2

6.84e-0525943C1704230
DiseaseSubependymal Giant Cell Astrocytoma

AR NOTCH1 NOTCH2

6.84e-0525943C0205768
DiseaseMixed oligoastrocytoma

AR NOTCH1 NOTCH2

6.84e-0525943C0547065
DiseaseChildhood Cerebral Astrocytoma

AR NOTCH1 NOTCH2

6.84e-0525943C0338070
DiseaseGemistocytic astrocytoma

AR NOTCH1 NOTCH2

7.72e-0526943C0334581
DiseaseProtoplasmic astrocytoma

AR NOTCH1 NOTCH2

7.72e-0526943C0334580
DiseaseFibrillary Astrocytoma

AR NOTCH1 NOTCH2

7.72e-0526943C0334582
DiseaseAnaplastic astrocytoma

AR NOTCH1 NOTCH2

8.66e-0527943C0334579
Diseaselithostathine-1-alpha measurement

REG1A REG1B

2.09e-047942EFO_0801083
Diseaseadenocarcinoma (implicated_via_orthology)

NOTCH1 NOTCH2

2.09e-047942DOID:299 (implicated_via_orthology)
Diseaseobsolete_interleukin-1 alpha measurement

REG1A REG1B

2.09e-047942EFO_0802653
Diseasecentral nervous system cancer (implicated_via_orthology)

NOTCH1 NOTCH2

2.09e-047942DOID:3620 (implicated_via_orthology)
Diseasesunburn

USP49 SRPK2 HERC2 NOTCH2

2.56e-0496944EFO_0003958
DiseaseNeoplasm of uncertain or unknown behavior of breast

HERC2 NOTCH1 NOTCH2

3.06e-0441943C0496956
DiseaseBreast adenocarcinoma

HERC2 NOTCH1 NOTCH2

3.06e-0441943C0858252
Diseasehypertension

RNF213 SLC12A9 SBF2 RXFP2 KCNK3 FRMD3

4.57e-04307946EFO_0000537
Diseasephenylacetylglutamine measurement

RXFP2 LRRC8B

6.49e-0412942EFO_0021013
Diseaseretinopathy of prematurity (biomarker_via_orthology)

EPOR NOTCH1

6.49e-0412942DOID:13025 (biomarker_via_orthology)
Diseaseresponse to carboplatin, methylcobalamin deficiency type cblE, response to antineoplastic agent

LRRC8B APOL2

6.49e-0412942GO_0097327, GO_0097328, MONDO_0009354
DiseaseFanconi anemia

FANCL FANCB

8.91e-0414942cv:C0015625
DiseaseBone marrow hypocellularity

FANCL FANCB

1.49e-0318942C1855710
DiseaseManic Disorder

TRPM2 SRPK2 TRANK1

1.53e-0371943C0024713
DiseaseAlopecia

ODC1 AR

1.66e-0319942C0002170
Diseaseepilepsy (implicated_via_orthology)

GRIN2D SLC12A4 SBF2 SLC12A7

1.86e-03163944DOID:1826 (implicated_via_orthology)
DiseaseManic

TRPM2 SRPK2 TRANK1

2.00e-0378943C0338831
DiseaseNystagmus

REG1A REG1B

2.03e-0321942HP_0000639
DiseaseDepression, Bipolar

TRPM2 SRPK2 TRANK1

2.08e-0379943C0005587
Diseasecongenital heart disease (is_implicated_in)

NPHP4 NOTCH1

2.65e-0324942DOID:1682 (is_implicated_in)
Diseasemean corpuscular hemoglobin concentration

USP49 FAM234A NAB1 CPS1 RIF1 JOSD1 SLC12A7 ARHGAP21 EPB41L2 DCAF12

2.74e-0311059410EFO_0004528
Diseaseerythrocyte count, mean corpuscular hemoglobin concentration, mean corpuscular volume, hematocrit, obsolete_red blood cell distribution width, mean corpuscular hemoglobin

USP49 FAM234A

2.87e-0325942EFO_0004305, EFO_0004348, EFO_0004526, EFO_0004527, EFO_0004528, EFO_0005192
Diseaseinflammatory bowel disease (implicated_via_orthology)

EPB41L1 EPB41L2

2.87e-0325942DOID:0050589 (implicated_via_orthology)
DiseaseFanconi Anemia

FANCL FANCB

2.87e-0325942C0015625
Diseaseresponse to venlafaxine

RXFP2 DCAF12

2.87e-0325942EFO_0006328
Diseaseeye color

TRANK1 SLC12A9 HERC2

3.01e-0390943EFO_0003949
DiseasePancytopenia

FANCL FANCB

3.10e-0326942C0030312
Diseasebrain cancer (implicated_via_orthology)

NOTCH1 NOTCH2

3.10e-0326942DOID:1319 (implicated_via_orthology)
DiseaseAcute monocytic leukemia

FANCL FANCB

3.10e-0326942C0023465
Diseaseprimary aldosteronism

KLHL1 RXFP2

3.10e-0326942MONDO_0001422

Protein segments in the cluster

PeptideGeneStartEntry
RWTPKAAHVLRKPIF

FAM234A

361

Q9H0X4
QHRQWFLKEFPRLKR

APOL2

76

Q9BQE5
PWKGLQTNFRLLKRR

APOBEC3D

366

Q96AK3
WAHILALRALQDPKK

HSD3B1

231

P14060
AKLLREGWVHANRPK

GPR32

241

O75388
LQLLKWPLRFVIIHK

SH3BP2

41

P78314
KLLWPKRESLLHEGL

BEST1

411

O76090
GLHLWKVEKRRVNLP

CAPN10

421

Q9HC96
FKKLRHPLNWILVNL

OPN1LW

81

P04000
FKKLRHPLNWILVNL

OPN1MW3

81

P0DN78
KVLRPHQREGVKFLW

RAD54L

151

Q92698
LPGIRKWLKQLFHRL

RGPD5

451

Q99666
LPGIRKWLKQLFHRL

RGPD8

451

O14715
FKKLRHPLNWILVNL

OPN1MW2

81

P0DN77
LHSVLFRKQPFLWRA

KIAA0895L

321

Q68EN5
KRKRKHGSLWLPEGF

NOTCH2

1701

Q04721
PLREVSGLLKRRFHW

PDHB

11

P11177
GFKLPNHRSAKRLWK

EPB41L1

351

Q9H4G0
LGLFAWHRRRQKEKG

MEGF11

866

A6BM72
LRKHPIKRAAEGWAA

NOTCH1

1626

P46531
FPERKHPWQSELLRK

KCTD16

411

Q68DU8
KPRWFVLDVTKHQLR

SBF2

1761

Q86WG5
KPLHVRRLQKALRDW

NAB1

61

Q13506
FWARLLERLFKQLHP

GPC1

166

P35052
HLIILPFKRRLEFLW

GPR155

716

Q7Z3F1
PDSLLLPHRVWKVKF

HERC2

4456

O95714
VLRLKPHKAGVQWRF

KCNK3

66

O14649
IGFKLPNHRAAKRLW

EPB41L2

471

O43491
LGRWRKKHLTFRILN

MMP19

101

Q99542
IQKQLIRHRWGLPQK

FAM205A

596

Q6ZU69
LLENVKRHLKRPVWI

FAM151B

116

Q6UXP7
KRHLKRPVWINADIL

FAM151B

121

Q6UXP7
RKLTPWKHQRLGKVN

MDM1

291

Q8TC05
RLLKINPDWKTHRLL

METTL9

136

Q9H1A3
TFRLLQKPLRWHDAL

MRC2

1136

Q9UBG0
RGDKRGKLPRWIQEH

ERCC2

686

P18074
LKLPLKRQHWICVRE

JOSD1

131

Q15040
VVKWAKALPGFRNLH

AR

716

P10275
VLLQKREKRGPLWRH

PLA2G4F

21

Q68DD2
WAKIILPRLIRKGNS

IAH1

61

Q2TAA2
KIPRWVFHLKNLKEL

LRRC8B

501

Q6P9F7
LSFLKKAIRLPPWHT

NPHP4

1141

O75161
FKKLRHPLNWILVNL

OPN1MW

81

P04001
VLNGPLILWRHVKAF

FANCB

136

Q8NB91
PDIKQWRLIRHTVKF

OSBPL8

661

Q9BZF1
WLNPLFKIGHKRRLE

ABCC4

26

O15439
LPGIRKWLKQLFHHL

RGPD3

451

A6NKT7
VGWLEPLLARIKHDR

GALNT1

216

Q10472
VFQGNKRIHLIKWPD

FRMD3

246

A2A2Y4
HQKWKFSRPGIRLLS

CPS1

26

P31327
REKVLFLLHPERWLG

C6orf141

86

Q5SZD1
KHKFPWLSEAGLRLL

CDK10

286

Q15131
QFGWDHSLHKRKRLP

DCAF12

26

Q5T6F0
AKLLREGWVHANRPK

GPR32P1

241

Q8NGA4
AALDGPKWFQHRRLL

CYP4X1

126

Q8N118
HSWKRLKDIRKIFPG

ALOX12B

231

O75342
PSDFKIILGKHWRLR

MASP1

511

P48740
LLSHRRALKQKIWPG

EPOR

271

P19235
LLVLEGPKWLQHRKL

CYP4B1

126

P13584
LARKLRPAQKHWVLQ

CA5BP1

76

Q8WTZ4
GPVRRELKQFLGWLK

CRLF1

361

O75462
LPFLLRQHKVWRKCR

SLC12A7

861

Q9Y666
RLRQWLQETHKGKIP

SEC14L1

261

Q92503
IERFWRNILLLPLHK

CARD16

161

Q5EG05
KHLRWLKALPRVTPF

ODC1

51

P11926
RPHELLQKLTAKWQR

P2RY6

311

Q15077
FNVWIGLHDPKKNRR

REG1A

96

P05451
SNVWIGLHDPKKNRR

REG1B

96

P48304
VRLPRLQHLHQWKAK

WARS2

131

Q9UGM6
LPGIRKWLKQLFHHL

RGPD4

451

Q7Z3J3
RERGAKHEAWLLLPF

STK16

86

O75716
KAIFIFIRWLLKLGH

TOR2A

191

Q8N2E6
KPLGIKLSRNIHLWD

FANCL

261

Q9NW38
FWHLRQAKPRKDIDP

RGS22

526

Q8NE09
KLWPLFVKLLGRTLH

RIF1

251

Q5UIP0
RPGIFKDLHQLTWLI

RXFP2

201

Q8WXD0
LERKRFLWQHQLLGL

INTS5

491

Q6P9B9
KEPILWKHGNLRNVL

MROH2B

1291

Q7Z745
LPFLLRQHKVWRKCR

SLC12A4

861

Q9UP95
HRIVPKLIQNWKIGL

CLEC2A

16

Q6UVW9
WNRLHQLKALKTRRP

CDK5RAP1

156

Q96SZ6
GKERVPILWHFLQKE

RNF213

4761

Q63HN8
LRRKGWVEKKFHFLP

TTLL8

71

A6PVC2
LRTKWGRRGHIKEPL

TSR1

731

Q2NL82
AFKWRGKPLFVRHRT

UQCRFS1

166

P47985
SIHWRRDKLVLPAKN

NCAM2

431

O15394
RHWKNFALVPLLREA

TRPV1

786

Q8NER1
KLKRILRQEHWPSFE

TRPM2

1401

O94759
DVRKDHVKFWRPQLL

SLC12A9

521

Q9BXP2
RRGELRHITKLKPWS

SRPK2

626

P78362
PQVLRLHLKRFRWSG

USP49

546

Q70CQ1
IPLTFVWHRRLKNQK

ROS1

1876

P08922
WKKIPLNALIRRFAH

USP37

376

Q86T82
FDIKLLRNIPRWTHL

TPTE2

161

Q6XPS3
LINLHLKVGWKRGNP

TARBP1

761

Q13395
GSPLLAKQVWLKRRL

TRANK1

1061

O15050
GWLHFRPLVTDKGKR

ARHGAP21

936

Q5T5U3
RKAFAWKPQLLRHQR

ZNF605

511

Q86T29
NRKLPLRKDDASWLH

XYLT2

751

Q9H1B5
LKANPGAWILRLRKG

UGGT1

1156

Q9NYU2
LWLKKHRRTPQEQLF

ZBBX

321

A8MT70
VKHILRLRWKLFSHP

KLHL1

11

Q9NR64
IALHKGSRWKRPIDL

GRIN2D

791

O15399