Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	enzyme regulator activity	RGPD4 MAPK8IP1 ERBB3 PPP2R5D DLC1 RGPD8 GOPC NET1 MYCBP2 CYTH3 RGPD3 MAP3K20 C4A C4B PPP6R1 ARHGEF11 PPP1R14B BIRC6 PIK3R5 MAPK8IP2 SH3BP5 RGPD5	1.47e-07	1418	88	22	GO:0030234
GeneOntologyMolecularFunction	kinesin binding	SPTBN5 MAPK8IP1 KIF1B TRAK2 MAPK8IP2	4.33e-06	55	88	5	GO:0019894
GeneOntologyMolecularFunction	nucleoside-triphosphatase regulator activity	RGPD4 DLC1 RGPD8 GOPC NET1 MYCBP2 CYTH3 RGPD3 ARHGEF11 SH3BP5 RGPD5	1.39e-05	507	88	11	GO:0060589
GeneOntologyMolecularFunction	GTPase regulator activity	RGPD4 DLC1 RGPD8 GOPC NET1 MYCBP2 CYTH3 RGPD3 ARHGEF11 SH3BP5 RGPD5	1.39e-05	507	88	11	GO:0030695
GeneOntologyMolecularFunction	glycogen phosphorylase activity	PYGB PYGL	5.74e-05	3	88	2	GO:0008184
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	RGPD4 RNF4 RGPD8 MYCBP2 TRIM32 RGPD3 ARIH1 RNF217 BIRC6 TAF1L	8.47e-05	512	88	10	GO:0019787
GeneOntologyMolecularFunction	SUMO ligase activity	RGPD4 RGPD8 RGPD3	8.93e-05	20	88	3	GO:0061665
GeneOntologyMolecularFunction	aminoacyltransferase activity	RGPD4 RNF4 RGPD8 MYCBP2 TRIM32 RGPD3 ARIH1 RNF217 BIRC6 TAF1L	1.16e-04	532	88	10	GO:0016755
GeneOntologyMolecularFunction	1,4-alpha-oligoglucan phosphorylase activity	PYGB PYGL	1.90e-04	5	88	2	GO:0004645
GeneOntologyMolecularFunction	ubiquitin-like protein ligase activity	RGPD4 RNF4 RGPD8 MYCBP2 TRIM32 RGPD3 ARIH1 RNF217	3.72e-04	398	88	8	GO:0061659
GeneOntologyMolecularFunction	ubiquitin conjugating enzyme binding	RNF4 ARIH1 RNF217	5.32e-04	36	88	3	GO:0031624
GeneOntologyMolecularFunction	SUMO transferase activity	RGPD4 RGPD8 RGPD3	5.32e-04	36	88	3	GO:0019789
GeneOntologyMolecularFunction	small GTPase binding	RGPD4 RBSN RGPD8 MYCBP2 RGPD3 PPP6R1 RIMS2	5.42e-04	321	88	7	GO:0031267
GeneOntologyMolecularFunction	acyltransferase activity	RGPD4 RNF4 RGPD8 MYCBP2 TRIM32 RGPD3 ARIH1 PLA2G4E RNF217 BIRC6 TAF1L	5.90e-04	775	88	11	GO:0016746
GeneOntologyMolecularFunction	enzyme activator activity	RGPD4 ERBB3 PPP2R5D DLC1 RGPD8 RGPD3 MAP3K20 ARHGEF11 MAPK8IP2 RGPD5	6.15e-04	656	88	10	GO:0008047
GeneOntologyMolecularFunction	ubiquitin-like protein conjugating enzyme binding	RNF4 ARIH1 RNF217	8.39e-04	42	88	3	GO:0044390
GeneOntologyMolecularFunction	complement component C1q complex binding	C4A C4B	8.44e-04	10	88	2	GO:0001849
GeneOntologyMolecularFunction	cytoskeletal protein binding	SPTBN5 MAPK8IP1 MYO3A DLC1 MYH14 TRIM32 SYNE1 KIF1B PPP1R18 TRAK2 KATNAL1 DBN1 MAPK8IP2	1.02e-03	1099	88	13	GO:0008092
GeneOntologyMolecularFunction	voltage-gated chloride channel activity	CLCN1 CLCN6	1.03e-03	11	88	2	GO:0005247
GeneOntologyMolecularFunction	GTPase binding	RGPD4 RBSN RGPD8 MYCBP2 RGPD3 PPP6R1 RIMS2	1.06e-03	360	88	7	GO:0051020
GeneOntologyMolecularFunction	molecular function inhibitor activity	MAPK8IP1 TAF3 C4A C4B DBN1 PPP1R14B BIRC6 TAF1L SH3BP5	1.24e-03	596	88	9	GO:0140678
GeneOntologyMolecularFunction	peptidyl-prolyl cis-trans isomerase activity	RGPD4 RGPD8 RGPD3	1.40e-03	50	88	3	GO:0003755
GeneOntologyMolecularFunction	MAP-kinase scaffold activity	MAPK8IP1 MAPK8IP2	1.45e-03	13	88	2	GO:0005078
GeneOntologyMolecularFunction	GTPase activator activity	RGPD4 DLC1 RGPD8 RGPD3 ARHGEF11 RGPD5	1.47e-03	279	88	6	GO:0005096
GeneOntologyMolecularFunction	cis-trans isomerase activity	RGPD4 RGPD8 RGPD3	1.65e-03	53	88	3	GO:0016859
GeneOntologyMolecularFunction	cytoskeletal motor activity	MYO3A MYH14 KIF1B DNAH5	1.84e-03	118	88	4	GO:0003774
GeneOntologyMolecularFunction	kinase regulator activity	MAPK8IP1 ERBB3 MAP3K20 PIK3R5 MAPK8IP2 SH3BP5	2.30e-03	305	88	6	GO:0019207
GeneOntologyMolecularFunction	JUN kinase binding	MAPK8IP1 MAPK8IP2	2.50e-03	17	88	2	GO:0008432
GeneOntologyMolecularFunction	voltage-gated monoatomic anion channel activity	CLCN1 CLCN6	2.50e-03	17	88	2	GO:0008308
GeneOntologyMolecularFunction	actin filament binding	SPTBN5 MYO3A MYH14 SYNE1 DBN1	3.31e-03	227	88	5	GO:0051015
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	NET1 MYCBP2 CYTH3 ARHGEF11 SH3BP5	3.57e-03	231	88	5	GO:0005085
GeneOntologyBiologicalProcess	NLS-bearing protein import into nucleus	RGPD4 RGPD8 RGPD3 RGPD5	1.30e-06	20	86	4	GO:0006607
GeneOntologyBiologicalProcess	positive regulation of glucokinase activity	RGPD4 RGPD8 RGPD3	5.77e-06	9	86	3	GO:0033133
GeneOntologyBiologicalProcess	positive regulation of hexokinase activity	RGPD4 RGPD8 RGPD3	8.22e-06	10	86	3	GO:1903301
GeneOntologyBiologicalProcess	regulation of glucokinase activity	RGPD4 RGPD8 RGPD3	1.94e-05	13	86	3	GO:0033131
GeneOntologyBiologicalProcess	regulation of hexokinase activity	RGPD4 RGPD8 RGPD3	2.46e-05	14	86	3	GO:1903299
GeneOntologyBiologicalProcess	modulation of excitatory postsynaptic potential	SYNE1 IGSF11 DBN1 RIMS2	1.57e-04	65	86	4	GO:0098815
GeneOntologyBiologicalProcess	regulation of mini excitatory postsynaptic potential	SYNE1 IGSF11	1.70e-04	5	86	2	GO:0061884
GeneOntologyBiologicalProcess	mini excitatory postsynaptic potential	SYNE1 IGSF11	1.70e-04	5	86	2	GO:0098816
GeneOntologyBiologicalProcess	excitatory postsynaptic potential	SYNE1 IGSF11 DBN1 RIMS2 MAPK8IP2	2.13e-04	130	86	5	GO:0060079
GeneOntologyCellularComponent	cytoplasmic periphery of the nuclear pore complex	RGPD4 RGPD8 RGPD3	3.84e-06	8	87	3	GO:1990723
GeneOntologyCellularComponent	nuclear pore cytoplasmic filaments	RGPD4 RGPD8 RGPD3	8.18e-06	10	87	3	GO:0044614
GeneOntologyCellularComponent	annulate lamellae	RGPD4 RGPD8 RGPD3	2.45e-05	14	87	3	GO:0005642
GeneOntologyCellularComponent	nuclear pore nuclear basket	RGPD4 RGPD8 RGPD3	5.43e-05	18	87	3	GO:0044615
GeneOntologyCellularComponent	nuclear inclusion body	RGPD4 RGPD8 RGPD3	7.54e-05	20	87	3	GO:0042405
GeneOntologyCellularComponent	SUMO ligase complex	RGPD4 RGPD8 RGPD3	8.77e-05	21	87	3	GO:0106068
GeneOntologyCellularComponent	symbiont cell surface	C4A C4B	4.72e-04	8	87	2	GO:0106139
GeneOntologyCellularComponent	nuclear protein-containing complex	RGPD4 TAF3 SFPQ DDX12P RGPD8 CTC1 SEM1 SYNE1 RGPD3 CUL7 PRPF8 TRRAP CWC22 TAF1L RGPD5	5.20e-04	1377	87	15	GO:0140513
GeneOntologyCellularComponent	nuclear envelope	RGPD4 TAF3 CUEDC2 RGPD8 SYNE1 RGPD3 DISP3 CC2D1B RGPD5	5.34e-04	560	87	9	GO:0005635
GeneOntologyCellularComponent	inclusion body	RGPD4 RGPD8 RGPD3 ARIH1	5.44e-04	90	87	4	GO:0016234
GeneOntologyCellularComponent	other organism part	C4A C4B	6.05e-04	9	87	2	GO:0044217
GeneOntologyCellularComponent	nuclear membrane	RGPD4 TAF3 CUEDC2 RGPD8 SYNE1 RGPD3 DISP3	6.34e-04	349	87	7	GO:0031965
GeneOntologyCellularComponent	cytoplasmic region	SPTBN5 SFPQ KIF1B TRAK2 LRRC43 RIMS2 DNAH5	7.61e-04	360	87	7	GO:0099568
GeneOntologyCellularComponent	nuclear pore	RGPD4 RGPD8 RGPD3 RGPD5	8.40e-04	101	87	4	GO:0005643
GeneOntologyCellularComponent	axonal growth cone	MAPK8IP1 TRAK2 DBN1	8.71e-04	45	87	3	GO:0044295
GeneOntologyCellularComponent	U2-type catalytic step 1 spliceosome	PRPF8 CWC22	1.51e-03	14	87	2	GO:0071006
GeneOntologyCellularComponent	catalytic step 1 spliceosome	PRPF8 CWC22	1.51e-03	14	87	2	GO:0071012
GeneOntologyCellularComponent	cortical cytoskeleton	SPTBN5 DLC1 DBN1 RIMS2	2.07e-03	129	87	4	GO:0030863
GeneOntologyCellularComponent	plasma membrane bounded cell projection cytoplasm	SPTBN5 SFPQ KIF1B TRAK2 LRRC43 DNAH5	2.09e-03	317	87	6	GO:0032838
MousePheno	failure of blastocyst formation	RGPD4 RGPD8 RGPD3 ZNF407	1.46e-05	31	68	4	MP:0012129
MousePheno	abnormal blastocyst formation	RGPD4 RGPD8 RGPD3 ZNF407	3.70e-05	39	68	4	MP:0012128
MousePheno	elevated level of mitotic sister chromatid exchange	RGPD4 RGPD8 RGPD3	5.89e-05	16	68	3	MP:0003701
Domain	Grip	RGPD4 RGPD8 RGPD3 RGPD5	1.29e-07	11	85	4	SM00755
Domain	GRIP	RGPD4 RGPD8 RGPD3 RGPD5	1.29e-07	11	85	4	PF01465
Domain	Ran_BP1	RGPD4 RGPD8 RGPD3 RGPD5	1.92e-07	12	85	4	PF00638
Domain	GRIP_dom	RGPD4 RGPD8 RGPD3 RGPD5	1.92e-07	12	85	4	IPR000237
Domain	GRIP	RGPD4 RGPD8 RGPD3 RGPD5	1.92e-07	12	85	4	PS50913
Domain	RANBD1	RGPD4 RGPD8 RGPD3 RGPD5	1.92e-07	12	85	4	PS50196
Domain	RanBD	RGPD4 RGPD8 RGPD3 RGPD5	2.77e-07	13	85	4	SM00160
Domain	Ran_bind_dom	RGPD4 RGPD8 RGPD3 RGPD5	2.77e-07	13	85	4	IPR000156
Domain	PH_dom-like	RGPD4 SPTBN5 MAPK8IP1 RGPD8 NET1 CYTH3 NBEAL2 KIF1B RGPD3 ARHGEF11 MAPK8IP2 RGPD5	4.97e-07	426	85	12	IPR011993
Domain	GCC2_Rab_bind	RGPD4 RGPD8 RGPD3	3.14e-06	7	85	3	IPR032023
Domain	Rab_bind	RGPD4 RGPD8 RGPD3	3.14e-06	7	85	3	PF16704
Domain	-	RGPD4 RGPD8 RGPD3	1.07e-05	10	85	3	1.10.220.60
Domain	-	RGPD4 SPTBN5 MAPK8IP1 RGPD8 NET1 CYTH3 KIF1B RGPD3 ARHGEF11 MAPK8IP2	1.12e-05	391	85	10	2.30.29.30
Domain	PHOSPHORYLASE	PYGB PYGL	6.12e-05	3	85	2	PS00102
Domain	Phosphorylase	PYGB PYGL	6.12e-05	3	85	2	PF00343
Domain	Glycg_phsphrylas	PYGB PYGL	6.12e-05	3	85	2	IPR011833
Domain	Glyco_trans_35	PYGB PYGL	6.12e-05	3	85	2	IPR000811
Domain	Anaphylatoxin_comp_syst	C4A C4B	2.03e-04	5	85	2	IPR018081
Domain	Anaphylatoxn_comp_syst_dom	C4A C4B	2.03e-04	5	85	2	IPR001840
Domain	ANATO	C4A C4B	4.24e-04	7	85	2	SM00104
Domain	ANATO	C4A C4B	4.24e-04	7	85	2	PF01821
Domain	APC_su10/DOC_dom	MYCBP2 CUL7	4.24e-04	7	85	2	IPR004939
Domain	DOC	MYCBP2 CUL7	4.24e-04	7	85	2	PS51284
Domain	ANAPHYLATOXIN_2	C4A C4B	4.24e-04	7	85	2	PS01178
Domain	ANAPHYLATOXIN_1	C4A C4B	4.24e-04	7	85	2	PS01177
Domain	APC10	MYCBP2 CUL7	4.24e-04	7	85	2	SM01337
Domain	Anaphylatoxin/fibulin	C4A C4B	4.24e-04	7	85	2	IPR000020
Domain	ANAPC10	MYCBP2 CUL7	4.24e-04	7	85	2	PF03256
Domain	Thiol-ester_cl	C4A C4B	5.63e-04	8	85	2	PF10569
Domain	MacrogloblnA2_thiol-ester-bond	C4A C4B	5.63e-04	8	85	2	IPR019565
Domain	MacrogloblnA2_CS	C4A C4B	5.63e-04	8	85	2	IPR019742
Domain	Cl-channel_core	CLCN1 CLCN6	7.22e-04	9	85	2	IPR014743
Domain	-	CLCN1 CLCN6	7.22e-04	9	85	2	1.10.3080.10
Domain	Voltage_CLC	CLCN1 CLCN6	7.22e-04	9	85	2	PF00654
Domain	Cl-channel_volt-gated	CLCN1 CLCN6	7.22e-04	9	85	2	IPR001807
Domain	ARM-type_fold	PPP2R5D PI4KA NBEAL2 PPP6R1 CUL7 TRRAP CWC22	8.96e-04	339	85	7	IPR016024
Domain	A2M_N	C4A C4B	9.00e-04	10	85	2	PF01835
Domain	A2M_N	C4A C4B	9.00e-04	10	85	2	IPR002890
Domain	A-macroglobulin_rcpt-bd	C4A C4B	9.00e-04	10	85	2	IPR009048
Domain	ALPHA_2_MACROGLOBULIN	C4A C4B	9.00e-04	10	85	2	PS00477
Domain	A2M	C4A C4B	9.00e-04	10	85	2	PF00207
Domain	E3_UB_ligase_RBR	ARIH1 RNF217	9.00e-04	10	85	2	IPR031127
Domain	A2M_N_2	C4A C4B	9.00e-04	10	85	2	IPR011625
Domain	A2M_comp	C4A C4B	9.00e-04	10	85	2	IPR011626
Domain	A2M_N_2	C4A C4B	9.00e-04	10	85	2	PF07703
Domain	A2M_recep	C4A C4B	9.00e-04	10	85	2	PF07677
Domain	A2M_comp	C4A C4B	9.00e-04	10	85	2	PF07678
Domain	Macroglobln_a2	C4A C4B	9.00e-04	10	85	2	IPR001599
Domain	IBR	ARIH1 RNF217	1.80e-03	14	85	2	SM00647
Domain	IBR	ARIH1 RNF217	1.80e-03	14	85	2	PF01485
Domain	IBR_dom	ARIH1 RNF217	2.07e-03	15	85	2	IPR002867
Domain	-	PI4KA TRRAP	2.36e-03	16	85	2	1.10.1070.11
Domain	PI3Kc	PI4KA TRRAP	2.36e-03	16	85	2	SM00146
Domain	C345C	C4A C4B	2.66e-03	17	85	2	SM00643
Domain	PI3/4_kinase_cat_dom	PI4KA TRRAP	2.99e-03	18	85	2	IPR000403
Domain	PI3_PI4_kinase	PI4KA TRRAP	2.99e-03	18	85	2	PF00454
Domain	PI3_4_KINASE_3	PI4KA TRRAP	2.99e-03	18	85	2	PS50290
Domain	PI3_4_KINASE_1	PI4KA TRRAP	2.99e-03	18	85	2	PS00915
Domain	PI3_4_KINASE_2	PI4KA TRRAP	2.99e-03	18	85	2	PS00916
Domain	Terpenoid_cyclase/PrenylTrfase	C4A C4B	2.99e-03	18	85	2	IPR008930
Domain	C2	OTOF CC2D1B PLA2G4E RIMS2	3.02e-03	131	85	4	PF00168
Domain	NTR	C4A C4B	3.33e-03	19	85	2	PF01759
Domain	Netrin_module_non-TIMP	C4A C4B	3.33e-03	19	85	2	IPR018933
Domain	C2	OTOF CC2D1B PLA2G4E RIMS2	3.54e-03	137	85	4	SM00239
Domain	CBS_dom	CLCN1 CLCN6	3.69e-03	20	85	2	IPR000644
Domain	CBS	CLCN1 CLCN6	3.69e-03	20	85	2	PF00571
Domain	CBS	CLCN1 CLCN6	3.69e-03	20	85	2	PS51371
Domain	PDZ	GOPC PDZK1 ARHGEF11 RIMS2	3.93e-03	141	85	4	PF00595
Domain	C2	OTOF CC2D1B PLA2G4E RIMS2	4.03e-03	142	85	4	PS50004
Domain	TPR-like_helical_dom	RGPD4 RGPD8 RGPD3 TRRAP RGPD5	4.23e-03	233	85	5	IPR011990
Domain	-	RBSN TAF3 RNF4 MYCBP2 TRIM32 ARIH1 RIMS2	4.36e-03	449	85	7	3.30.40.10
Pubmed	Complex genomic rearrangements lead to novel primate gene function.	RGPD4 RGPD8 RGPD3 RGPD5	1.33e-09	7	88	4	15710750
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	RGPD4 MAPK8IP1 SFPQ PPP2R5D ZSCAN12 RGPD8 MYCBP2 CYTH3 SYNE1 PI4KA RGPD3 PPP6R1 DBN1 ARHGEF11 MAPK8IP2 SH3BP5	2.37e-09	963	88	16	28671696
Pubmed	Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.	RGPD4 MYO3A SFPQ RGPD8 MYH14 TRIM32 SYNE1 RGPD3 PYGB PYGL C4A C4B DBN1 PRPF8 RGPD5	3.23e-09	844	88	15	25963833
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	PPP2R5D TRIM32 KIF1B MAP3K20 PPP6R1 GIGYF1 DBN1 CUL7 BIRC6 ARAF KIAA0753	1.80e-08	446	88	11	24255178
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	RGPD4 SETDB1 NEK1 RGPD8 MYCBP2 RGPD3 ZBTB10 PPP6R1 BIRC6 ARAF	1.11e-07	418	88	10	34709266
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	NET1 TRIM32 SYNE1 PI4KA PDZK1 RGPD3 UTP14A MAP3K20 GNL2 PPP1R18 TRMT1L ARHGEF11 YTHDC1 TRRAP TAF1L ARAF ATP6V0A2	1.84e-07	1497	88	17	31527615
Pubmed	Transcription factor Foxp3 and its protein partners form a complex regulatory network.	RGPD4 RGPD8 RGPD3 UTP14A GNL2 PPP1R18 TRMT1L ARIH1 TAF1L	4.32e-07	370	88	9	22922362
Pubmed	Nup358, a nucleoporin, functions as a key determinant of the nuclear pore complex structure remodeling during skeletal myogenesis.	RGPD4 RGPD8 RGPD3	5.44e-07	7	88	3	21205196
Pubmed	Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons.	RGPD4 RGPD8 RGPD3	5.44e-07	7	88	3	18949001
Pubmed	Selective impairment of a subset of Ran-GTP-binding domains of ran-binding protein 2 (Ranbp2) suffices to recapitulate the degeneration of the retinal pigment epithelium (RPE) triggered by Ranbp2 ablation.	RGPD4 RGPD8 RGPD3	5.44e-07	7	88	3	25187515
Pubmed	Interconversion of red opsin isoforms by the cyclophilin-related chaperone protein Ran-binding protein 2.	RGPD4 RGPD8 RGPD3	5.44e-07	7	88	3	9037092
Pubmed	Localization of the Ran-GTP binding protein RanBP2 at the cytoplasmic side of the nuclear pore complex.	RGPD4 RGPD8 RGPD3	5.44e-07	7	88	3	8603673
Pubmed	Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).	RGPD4 RGPD8 RGPD3	5.44e-07	7	88	3	26632511
Pubmed	Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis.	RGPD4 RGPD8 RGPD3	5.44e-07	7	88	3	24403063
Pubmed	Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors.	RGPD4 RGPD8 RGPD3	5.44e-07	7	88	3	23818861
Pubmed	Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene.	RGPD4 RGPD8 RGPD3	5.44e-07	7	88	3	11353387
Pubmed	Microglial activation in an amyotrophic lateral sclerosis-like model caused by Ranbp2 loss and nucleocytoplasmic transport impairment in retinal ganglion neurons.	RGPD4 RGPD8 RGPD3	5.44e-07	7	88	3	30944974
Pubmed	Nucleoporin Nup358 drives the differentiation of myeloid-biased multipotent progenitors by modulating HDAC3 nuclear translocation.	RGPD4 RGPD8 RGPD3	5.44e-07	7	88	3	38838144
Pubmed	Kinesin-1 and mitochondrial motility control by discrimination of structurally equivalent but distinct subdomains in Ran-GTP-binding domains of Ran-binding protein 2.	RGPD4 RGPD8 RGPD3	5.44e-07	7	88	3	23536549
Pubmed	Retina-specifically expressed novel subtypes of bovine cyclophilin.	RGPD4 RGPD8 RGPD3	5.44e-07	7	88	3	7559465
Pubmed	Mst1, RanBP2 and eIF4G are new markers for in vivo PI3K activation in murine and human prostate.	RGPD4 RGPD8 RGPD3	5.44e-07	7	88	3	17372272
Pubmed	Proteostatic Remodeling of Small Heat Shock Chaperones─Crystallins by Ran-Binding Protein 2─and the Peptidyl-Prolyl cis-trans Isomerase and Chaperone Activities of Its Cyclophilin Domain.	RGPD4 RGPD8 RGPD3	5.44e-07	7	88	3	38657106
Pubmed	Identification of RanBP2- and kinesin-mediated transport pathways with restricted neuronal and subcellular localization.	RGPD4 RGPD8 RGPD3	5.44e-07	7	88	3	12191015
Pubmed	Ranbp2 haploinsufficiency mediates distinct cellular and biochemical phenotypes in brain and retinal dopaminergic and glia cells elicited by the Parkinsonian neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).	RGPD4 RGPD8 RGPD3	5.44e-07	7	88	3	22821000
Pubmed	Neuroprotection resulting from insufficiency of RANBP2 is associated with the modulation of protein and lipid homeostasis of functionally diverse but linked pathways in response to oxidative stress.	RGPD4 RGPD8 RGPD3	5.44e-07	7	88	3	20682751
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	ERBB3 TRIM32 UTP14A PYGB CC2D1B C4A C4B PPP6R1 GIGYF1 CWC22 ARAF	7.77e-07	650	88	11	38777146
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	SFPQ MYCBP2 MYH14 UTP14A GNL2 PYGB PYGL CUL7 PRPF8 TRRAP BIRC6	8.13e-07	653	88	11	22586326
Pubmed	The distribution of phosphorylated SR proteins and alternative splicing are regulated by RANBP2.	RGPD4 RGPD8 RGPD3	8.69e-07	8	88	3	22262462
Pubmed	The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity.	RGPD4 RGPD8 RGPD3	8.69e-07	8	88	3	21670213
Pubmed	Zap70 and downstream RanBP2 are required for the exact timing of the meiotic cell cycle in oocytes.	RGPD4 RGPD8 RGPD3	8.69e-07	8	88	3	28745977
Pubmed	Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis.	RGPD4 RGPD8 RGPD3	8.69e-07	8	88	3	27412403
Pubmed	Mice lacking Ran binding protein 1 are viable and show male infertility.	RGPD4 RGPD8 RGPD3	8.69e-07	8	88	3	21310149
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	RGPD4 MAPK8IP1 RBSN SFPQ PPP2R5D RGPD8 GOPC MYCBP2 PI4KA RGPD3 PYGB PPP6R1 DBN1 BIRC6	1.02e-06	1139	88	14	36417873
Pubmed	Resolution of sister centromeres requires RanBP2-mediated SUMOylation of topoisomerase IIalpha.	RGPD4 RGPD8 RGPD3	1.30e-06	9	88	3	18394993
Pubmed	The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.	RGPD4 RGPD8 RGPD3	1.30e-06	9	88	3	11553612
Pubmed	The zinc finger cluster domain of RanBP2 is a specific docking site for the nuclear export factor, exportin-1.	RGPD4 RGPD8 RGPD3	1.30e-06	9	88	3	10601307
Pubmed	The cyclophilin-like domain mediates the association of Ran-binding protein 2 with subunits of the 19 S regulatory complex of the proteasome.	RGPD4 RGPD8 RGPD3	1.30e-06	9	88	3	9733766
Pubmed	Loss of Ranbp2 in motoneurons causes disruption of nucleocytoplasmic and chemokine signaling, proteostasis of hnRNPH3 and Mmp28, and development of amyotrophic lateral sclerosis-like syndromes.	RGPD4 RGPD8 RGPD3	1.30e-06	9	88	3	28100513
Pubmed	Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.	RGPD4 RGPD8 RGPD3	1.30e-06	9	88	3	28877029
Pubmed	Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function.	RGPD4 RGPD8 RGPD3	1.30e-06	9	88	3	17887960
Pubmed	HAUSP regulates c-MYC expression via de-ubiquitination of TRRAP.	MYO3A DBN1 TRRAP CWC22	1.67e-06	34	88	4	25925205
Pubmed	Cyclophilin-related protein RanBP2 acts as chaperone for red/green opsin.	RGPD4 RGPD8 RGPD3	1.85e-06	10	88	3	8857542
Pubmed	The RanBP2/RanGAP1*SUMO1/Ubc9 SUMO E3 ligase is a disassembly machine for Crm1-dependent nuclear export complexes.	RGPD4 RGPD8 RGPD3	1.85e-06	10	88	3	27160050
Pubmed	Parkin ubiquitinates and promotes the degradation of RanBP2.	RGPD4 RGPD8 RGPD3	1.85e-06	10	88	3	16332688
Pubmed	Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.	RGPD4 RGPD8 RGPD3	1.85e-06	10	88	3	21859863
Pubmed	An Rtn4/Nogo-A-interacting micropeptide modulates synaptic plasticity with age.	RGPD4 RGPD8 RGPD3	2.55e-06	11	88	3	35771867
Pubmed	RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism.	RGPD4 RGPD8 RGPD3	2.55e-06	11	88	3	17069463
Pubmed	T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1.	RGPD4 RGPD8 RGPD3	2.55e-06	11	88	3	34110283
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	RGPD4 SFPQ RGPD8 MYH14 SYNE1 FAM178B RGPD3 UTP14A CC2D1B DBN1 LRRC43 PRPF8 RIMS2 ERICH6 RGPD5	3.15e-06	1442	88	15	35575683
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	TAF3 SFPQ MYCBP2 TRIM32 SYNE1 UTP14A GNL2 DBN1 PRPF8 YTHDC1 TRRAP CWC22 PIK3R5	3.30e-06	1082	88	13	38697112
Pubmed	Coordinated transport of phosphorylated amyloid-beta precursor protein and c-Jun NH2-terminal kinase-interacting protein-1.	MAPK8IP1 KIF1B MAPK8IP2	3.39e-06	12	88	3	16301330
Pubmed	Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1.	SETDB1 CLCN6 KIF1B CUL7	3.98e-06	42	88	4	7584044
Pubmed	Ankyrin-G induces nucleoporin Nup358 to associate with the axon initial segment of neurons.	RGPD4 RGPD8 RGPD3	4.40e-06	13	88	3	31427429
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	NEK1 UTP14A DISP3 ZNF407 CC2D1B CUL7 YTHDC1 BIRC6 KIAA0753	4.56e-06	493	88	9	15368895
Pubmed	Copy number analysis of complement C4A, C4B and C4A silencing mutation by real-time quantitative polymerase chain reaction.	C4A C4B	6.33e-06	2	88	2	22737222
Pubmed	Deficiency of C4 from donor or recipient mouse fails to prevent renal allograft rejection.	C4A C4B	6.33e-06	2	88	2	16565498
Pubmed	Complete deficiencies of complement C4A and C4B including 2-bp insertion in codon 1213 are genetic risk factors of systemic lupus erythematosus in Thai populations.	C4A C4B	6.33e-06	2	88	2	15998580
Pubmed	Structural polymorphism of murine C4 and its linkage to H-2.	C4A C4B	6.33e-06	2	88	2	7373044
Pubmed	High-throughput analysis of the C4 polymorphism by a combination of MLPA and isotype-specific ELISA's.	C4A C4B	6.33e-06	2	88	2	19062096
Pubmed	The chemical structure of the C4d fragment of the human complement component C4.	C4A C4B	6.33e-06	2	88	2	3696167
Pubmed	Restriction fragment length polymorphism of the murine C4 and Slp genes: two C4 groups.	C4A C4B	6.33e-06	2	88	2	1357031
Pubmed	Structural comparison of human C4A3 and C4B1 after proteolytic activation by C1s.	C4A C4B	6.33e-06	2	88	2	16098595
Pubmed	Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice.	C4A C4B	6.33e-06	2	88	2	19933335
Pubmed	Structural basis for the C4d.1/C4d.2 serologic allotypes of murine complement component C4.	C4A C4B	6.33e-06	2	88	2	2459207
Pubmed	Antigen-induced B cell apoptosis is independent of complement C4.	C4A C4B	6.33e-06	2	88	2	17645767
Pubmed	Increased frequency of C4B*Q0 alleles in patients with Henoch-Schönlein purpura.	C4A C4B	6.33e-06	2	88	2	15787745
Pubmed	Anti-DNA autoreactivity in C4-deficient mice.	C4A C4B	6.33e-06	2	88	2	12207352
Pubmed	Neuropil contraction in relation to Complement C4 gene copy numbers in independent cohorts of adolescent-onset and young adult-onset schizophrenia patients-a pilot study.	C4A C4B	6.33e-06	2	88	2	30026462
Pubmed	A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.	C4A C4B	6.33e-06	2	88	2	6559257
Pubmed	ARAF suppresses ERBB3 expression and metastasis in a subset of lung cancers.	ERBB3 ARAF	6.33e-06	2	88	2	35302851
Pubmed	Complement C4A and C4B Gene Copy Number Study in Alzheimer's Disease Patients.	C4A C4B	6.33e-06	2	88	2	27758680
Pubmed	Genetically determined partial complement C4 deficiency states are not independent risk factors for SLE in UK and Spanish populations.	C4A C4B	6.33e-06	2	88	2	22387014
Pubmed	Complement C4 Is Reduced in iPSC-Derived Astrocytes of Autism Spectrum Disorder Subjects.	C4A C4B	6.33e-06	2	88	2	34299197
Pubmed	Assessment of complement C4 gene copy number using the paralog ratio test.	C4A C4B	6.33e-06	2	88	2	20506482
Pubmed	Polymerase chain reaction based C4AQ0 and C4BQ0 genotyping: association with systemic lupus erythematosus in southwest Han Chinese.	C4A C4B	6.33e-06	2	88	2	12480675
Pubmed	Low C4, C4A and C4B gene copy numbers are stronger risk factors for juvenile-onset than for adult-onset systemic lupus erythematosus.	C4A C4B	6.33e-06	2	88	2	26800705
Pubmed	Complement C4 maintains peripheral B-cell tolerance in a myeloid cell dependent manner.	C4A C4B	6.33e-06	2	88	2	23749435
Pubmed	Copy number variations of complement component C4 are associated with Behçet's disease but not with ankylosing spondylitis associated with acute anterior uveitis.	C4A C4B	6.33e-06	2	88	2	23918728
Pubmed	Murine complement C4 is not required for experimental autoimmune encephalomyelitis.	C4A C4B	6.33e-06	2	88	2	15390104
Pubmed	Molecular genetics of androgen-dependent and -independent expression of mouse sex-limited protein.	C4A C4B	6.33e-06	2	88	2	3037333
Pubmed	Evidence of a role for C4 in modulating interstitial inflammation in experimental glomerulonephritis.	C4A C4B	6.33e-06	2	88	2	11726230
Pubmed	Quantitative variations in the expression of the mouse serum antigen Ss and its sex-limited allotype Slp.	C4A C4B	6.33e-06	2	88	2	4216347
Pubmed	Importance of the alpha 3-fragment of complement C4 for the binding with C4b-binding protein.	C4A C4B	6.33e-06	2	88	2	1699796
Pubmed	Sequence determination of the thiolester site of the fourth component of human complement.	C4A C4B	6.33e-06	2	88	2	6950384
Pubmed	Molecular cloning and characterization of complementary and genomic DNA clones for mouse C4 and Slp.	C4A C4B	6.33e-06	2	88	2	2997024
Pubmed	Visual demonstration of the organization of the human complement C4 and 21-hydroxylase genes by high-resolution fluorescence in situ hybridization.	C4A C4B	6.33e-06	2	88	2	8660986
Pubmed	Constitutive expression of Slp genes in mouse strain B10.WR directed by C4 regulatory sequences.	C4A C4B	6.33e-06	2	88	2	3624865
Pubmed	Tissue-specific RNA processing for the complement C4 gene transcript in the H-2k mouse strain.	C4A C4B	6.33e-06	2	88	2	8428773
Pubmed	Determination of the loss of function complement C4 exon 29 CT insertion using a novel paralog-specific assay in healthy UK and Spanish populations.	C4A C4B	6.33e-06	2	88	2	21857912
Pubmed	Complement C4 deficiency--a plausible risk factor for non-tuberculous mycobacteria (NTM) infection in apparently immunocompetent patients.	C4A C4B	6.33e-06	2	88	2	24638111
Pubmed	Isolation of cDNA clones specifying the fourth component of mouse complement and its isotype, sex-limited protein.	C4A C4B	6.33e-06	2	88	2	6208559
Pubmed	The role of the histocompatibility-2-linked Ss-Slp region in the control of mouse complement.	C4A C4B	6.33e-06	2	88	2	4514997
Pubmed	Transcriptional repression of C4 complement by hepatitis C virus proteins.	C4A C4B	6.33e-06	2	88	2	21345967
Pubmed	The inheritance of susceptibility to the Gross leukemia virus in mice.	C4A C4B	6.33e-06	2	88	2	5919331
Pubmed	An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene.	C4A C4B	6.33e-06	2	88	2	3167981
Pubmed	The dichotomous size variation of human complement C4 genes is mediated by a novel family of endogenous retroviruses, which also establishes species-specific genomic patterns among Old World primates.	C4A C4B	6.33e-06	2	88	2	7545960
Pubmed	Structural basis of homodimerization of the JNK scaffold protein JIP2 and its heterodimerization with JIP1.	MAPK8IP1 MAPK8IP2	6.33e-06	2	88	2	39013462
Pubmed	Insights on the relationship between complement component C4 serum concentrations and C4 gene copy numbers in a Western Australian systemic lupus erythematosus cohort.	C4A C4B	6.33e-06	2	88	2	30041577
Pubmed	Restriction fragment analysis of H-2 recombinant mouse strains with crossovers between E alpha and C4 genes.	C4A C4B	6.33e-06	2	88	2	2572548
Pubmed	The complement component C4 of mammals.	C4A C4B	6.33e-06	2	88	2	2302180
Interaction	RGPD4 interactions	RGPD4 RGPD8 RGPD3 RGPD5	2.13e-06	22	86	4	int:RGPD4
Interaction	ABCA1 interactions	GOPC PDZK1 ARHGEF11 PRPF8 RIMS2	3.38e-06	54	86	5	int:ABCA1
Interaction	RGPD2 interactions	RGPD4 RGPD8 RGPD3 RGPD5	5.03e-06	27	86	4	int:RGPD2
Interaction	LRRFIP2 interactions	GOPC MYCBP2 MYH14 PYGL DBN1 TRRAP	1.08e-05	117	86	6	int:LRRFIP2
Interaction	RGPD8 interactions	RGPD4 RGPD8 MYCBP2 RGPD3 RGPD5	1.61e-05	74	86	5	int:RGPD8
Interaction	DDX23 interactions	TAF3 SFPQ SYNE1 UTP14A GNL2 CUL7 PRPF8 YTHDC1 TRRAP CWC22	3.75e-05	480	86	10	int:DDX23
Interaction	PPP1CA interactions	SFPQ PPP2R5D CUEDC2 MYCBP2 ZBTB10 PPP1R18 PYGB PYGL DBN1 CUL7 PRPF8 PPP1R14B	3.86e-05	696	86	12	int:PPP1CA
Interaction	RGPD3 interactions	RGPD4 RGPD8 RGPD3 RGPD5	4.79e-05	47	86	4	int:RGPD3
Interaction	MCM2 interactions	RGPD4 MYO3A TAF3 SFPQ RGPD8 MYH14 TRIM32 SYNE1 RGPD3 PYGB PYGL C4A C4B TRRAP RGPD5	4.80e-05	1081	86	15	int:MCM2
Interaction	RGPD1 interactions	RGPD4 RGPD8 RGPD3 RGPD5	5.66e-05	49	86	4	int:RGPD1
Interaction	CLEC11A interactions	MYCBP2 CTC1 BIRC6 ARAF RGPD5	5.67e-05	96	86	5	int:CLEC11A
Interaction	BTG3 interactions	SETDB1 OTOF MYCBP2 TRIM32 SYNE1	6.26e-05	98	86	5	int:BTG3
Interaction	NUP43 interactions	TAF3 RNF4 RGPD8 PI4KA GNL2 ZBTB10 TRMT1L CUL7 YTHDC1 CWC22 RGPD5	6.94e-05	625	86	11	int:NUP43
Interaction	DLEU1 interactions	SETDB1 GOPC UTP14A	8.12e-05	20	86	3	int:DLEU1
Interaction	LIMA1 interactions	RNF4 GOPC MYCBP2 PPP1R18 GIGYF1 DBN1 CUL7 PRPF8 SH3BP5	8.92e-05	429	86	9	int:LIMA1
Interaction	SUZ12 interactions	SETDB1 TAF3 MYH14 SYNE1 PYGL TRMT1L DBN1 PRPF8 YTHDC1 TRRAP BIRC6	9.06e-05	644	86	11	int:SUZ12
Interaction	ODAD1 interactions	SETDB1 CYTH3 DNAH5 RGPD5	1.26e-04	60	86	4	int:ODAD1
Interaction	SOHLH1 interactions	CTC1 TRIM32 PI4KA CUL7 TRRAP	1.34e-04	115	86	5	int:SOHLH1
Cytoband	1q21	SETDB1 PDZK1 CASQ1 ARHGEF11	2.97e-05	91	88	4	1q21
Cytoband	2q13	RGPD8 RGPD3 RGPD5	3.12e-04	68	88	3	2q13
GeneFamily	Glycogen phosphorylases	PYGB PYGL	3.13e-05	3	59	2	437
GeneFamily	C3 and PZP like, alpha-2-macroglobulin domain containing	C4A C4B	3.71e-04	9	59	2	1234
GeneFamily	Chloride voltage-gated channels	CLCN1 CLCN6	4.63e-04	10	59	2	302
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	RGPD4 RGPD8 RGPD3 RGPD5	5.40e-04	115	59	4	769
GeneFamily	PDZ domain containing	GOPC PDZK1 ARHGEF11 RIMS2	1.53e-03	152	59	4	1220
GeneFamily	Mitogen-activated protein kinase kinase kinases\|RAF family	MAP3K20 ARAF	2.76e-03	24	59	2	654
GeneFamily	Actins\|Deafness associated genes	MYO3A OTOF MYH14	5.99e-03	113	59	3	1152
GeneFamily	Complement system\|Sushi domain containing	C4A C4B	6.14e-03	36	59	2	492
GeneFamily	Glycosyltransferase family 6\|Blood group antigens	C4A C4B	6.48e-03	37	59	2	454
Coexpression	NAKAYA_PBMC_FLUARIX_FLUVIRIN_AGE_18_50YO_CORRELATED_WITH_HAI_28DY_RESPONSE_AT_7DY_NEGATIVE	RGPD4 RBSN SFPQ RGPD8 GOPC CTC1 RGPD3 ZBTB10 ARIH1 YTHDC1 RGPD5	4.90e-07	474	87	11	M40991
Coexpression	CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1	RBSN TAF3 DLC1 FAM178B PDZK1 UTP14A ZBTB10 PPP1R18 RIMS2 SH3BP5	1.11e-05	534	87	10	M12522
Drug	DIBAH	SYNE1 PYGB PYGL	3.08e-06	8	88	3	CID000014487
Drug	5-(2-chloroethyl)uracil	PYGB PYGL	1.48e-05	2	88	2	CID010442204
Drug	6878P	PYGB PYGL	1.48e-05	2	88	2	CID002725013
Drug	AC1LBRFU	PYGB PYGL	1.48e-05	2	88	2	CID000562981
Drug	3H-pyrrolo[3,2-f]quinoline	TRIM32 SYNE1	1.48e-05	2	88	2	CID000906143
Drug	2-amino-6-chloropurine	SYNE1 PYGB PYGL	4.37e-05	18	88	3	CID005360349
Drug	3,5-dimethylphenyl isocyanate	PYGB PYGL	4.42e-05	3	88	2	CID000521488
Drug	5-ethyl-4-hydroxy-2-methyl-3(2H)-furanone	PYGB PYGL	4.42e-05	3	88	2	CID000093111
Drug	adenosine-5'-chloromethylphosphonate	PYGB PYGL	4.42e-05	3	88	2	CID000191554
Drug	hydan	PYGB PYGL	4.42e-05	3	88	2	CID000008360
Drug	EHMF	PYGB PYGL	4.42e-05	3	88	2	CID000033931
Drug	AC1L29EX	PYGB PYGL	4.42e-05	3	88	2	CID000043221
Drug	p-bromobenzoyl chloride	MAPK8IP1 MAPK8IP2	4.42e-05	3	88	2	CID000068515
Drug	5'-deoxy-5'-fluoro-5'-(methylthio)adenosine	PYGB PYGL	4.42e-05	3	88	2	CID000147839
Drug	pyridoxal 5'-methylenephosphonate	PYGB PYGL	4.42e-05	3	88	2	CID003082249
Drug	Plp 5'-mpa	PYGB PYGL	4.42e-05	3	88	2	CID003082151
Drug	2bq6	MAPK8IP1 MAPK8IP2	4.42e-05	3	88	2	CID006540266
Drug	glucose-1,2-cyclic phosphate	PYGB PYGL	4.42e-05	3	88	2	CID000191723
Drug	3'-FFdUrd	PYGB PYGL	4.42e-05	3	88	2	CID000072260
Drug	2',3',4',5,5'-pentachloro-2-biphenylol	PYGB PYGL	4.42e-05	3	88	2	CID000119518
Drug	AC1L8XK3	PYGB PYGL	4.42e-05	3	88	2	CID000409735
Drug	N-acetyl-N'-beta-D-glucopyranosyl urea	PYGB PYGL	4.42e-05	3	88	2	CID000446801
Drug	2-aminothiophenol	C4A C4B	4.42e-05	3	88	2	ctd:C005464
Drug	NSC758405	PYGB PYGL	4.42e-05	3	88	2	CID000003201
Drug	3,5-dinitrophenyl phosphate	PYGB PYGL	4.42e-05	3	88	2	CID000151920
Drug	riboflavin tetraacetate	PYGB PYGL	4.42e-05	3	88	2	CID000094186
Drug	pyridoxal phosphoglucose	PYGB PYGL	4.42e-05	3	88	2	CID000196007
Drug	Aspaminol	PYGB PYGL	4.42e-05	3	88	2	CID003084278
Drug	2,5-dimethyl-3-furanone	PYGB PYGL	4.42e-05	3	88	2	CID000085730
Drug	3,5-dinitrophenol	PYGB PYGL	4.42e-05	3	88	2	CID000011459
Drug	2evm	C4A IGFLR1 TRRAP BIRC6	8.61e-05	60	88	4	CID000736259
Drug	galocitabine	PYGB PYGL	8.82e-05	4	88	2	CID000065950
Drug	2,5-anhydro-D-mannitol 1-phosphate	PYGB PYGL	8.82e-05	4	88	2	CID000189134
Drug	AC1LAMW2	PYGB PYGL	8.82e-05	4	88	2	CID000491364
Drug	FdUrd-C8	PYGB PYGL	8.82e-05	4	88	2	CID000094262
Drug	Mem-CC	PYGB PYGL	8.82e-05	4	88	2	CID003081269
Drug	5-deoxyribose-1-phosphate	PYGB PYGL	8.82e-05	4	88	2	CID000135786
Drug	2H-5a	PYGB PYGL	8.82e-05	4	88	2	CID000440102
Drug	Ge-68	SYNE1 C4A	8.82e-05	4	88	2	CID000133044
Drug	ingliforib	PYGB PYGL	8.82e-05	4	88	2	CID006451325
Drug	uric acid riboside	PYGB PYGL	8.82e-05	4	88	2	CID000164933
Drug	pseudo-dl-glucose	PYGB PYGL	8.82e-05	4	88	2	CID000125259
Drug	Z-Cl	TRIM32 SYNE1	8.82e-05	4	88	2	CID000010387
Drug	BCIp4A	PYGB PYGL	8.82e-05	4	88	2	CID000192417
Drug	pyridoxal diphosphate	PYGB PYGL	8.82e-05	4	88	2	CID000125696
Drug	3'-chloromethotrexate	PYGB PYGL	8.82e-05	4	88	2	CID000097703
Drug	4-pyridoxic acid	PYGB PYGL PPP1R14B	9.34e-05	23	88	3	CID000006723
Drug	Xylazine [7361-61-7]; Down 200; 18.2uM; PC3; HT_HG-U133A	SPTBN5 DLC1 CLCN6 SYNE1 CUL7 MAPK8IP2	1.17e-04	197	88	6	4066_DN
Drug	Fluvastatin sodium salt [93957-55-2]; Up 200; 9.2uM; HL60; HT_HG-U133A	SPTBN5 CTC1 MYH14 PYGB ZNF407 RIMS2	1.24e-04	199	88	6	3032_UP
Drug	Cefsulodin sodium salt [52152-93-9]; Down 200; 7.2uM; HL60; HT_HG-U133A	DLC1 KIF1B UTP14A PYGB IGFLR1 ARHGEF11	1.27e-04	200	88	6	2988_DN
Drug	heptulose-2-P	PYGB PYGL	1.47e-04	5	88	2	CID000124823
Drug	m-anisidine	PYGB PYGL	1.47e-04	5	88	2	CID000010824
Drug	6-FPLP	PYGB PYGL	1.47e-04	5	88	2	CID000146246
Drug	gluconohydroximo-1,5-lactone	PYGB PYGL	1.47e-04	5	88	2	CID009576855
Drug	2-hydroxypropylphosphonate	PYGB PYGL	1.47e-04	5	88	2	CID000441028
Drug	DHPBU	PYGB PYGL	1.47e-04	5	88	2	CID000125914
Drug	6-FDPL	PYGB PYGL	1.47e-04	5	88	2	CID000129578
Drug	5'-isobutylthioinosine	PYGB PYGL	1.47e-04	5	88	2	CID003080910
Drug	3'-O-methylpyridoxal 5'-phosphate	PYGB PYGL	1.47e-04	5	88	2	CID003082179
Drug	GlcMan	PYGB PYGL	1.47e-04	5	88	2	CID000152120
Drug	U66985	PYGB PYGL	1.47e-04	5	88	2	CID000127224
Drug	indirubin-5-sulphonate	PYGB PYGL	1.47e-04	5	88	2	CID005288641
Drug	VaraU	PYGB PYGL	1.47e-04	5	88	2	CID000126501
Drug	AC1O3M08	PYGB PYGL	1.47e-04	5	88	2	CID006331955
Drug	AC1LCUXJ	PYGB PYGL	1.47e-04	5	88	2	CID000656425
Drug	6-amino-5-bromouracil	PYGB PYGL	1.47e-04	5	88	2	CID000080578
Drug	etafenone	PYGB PYGL	1.47e-04	5	88	2	CID000003275
Drug	ddEtUrd	PYGB PYGL	1.47e-04	5	88	2	CID000451452
Drug	5-trifluoromethyl-2'-deoxycytidine	PYGB PYGL	1.47e-04	5	88	2	CID000125618
Drug	BrdAdo	PYGB PYGL	1.47e-04	5	88	2	CID000055914
Drug	cyclamate	CLCN1 CLCN6 PDZK1	1.70e-04	28	88	3	CID000007533
Drug	cantharidic acid	PPP2R5D PYGB PYGL	1.90e-04	29	88	3	CID000002544
Drug	norstatine	PYGB PYGL	2.19e-04	6	88	2	CID000173844
Drug	CV-araU	PYGB PYGL	2.19e-04	6	88	2	CID006441877
Drug	2-thiothymidine	PYGB PYGL	2.19e-04	6	88	2	CID003005944
Drug	Carbocyclic Bvdc	PYGB PYGL	2.19e-04	6	88	2	CID006438602
Drug	AC1NDJ6Q	PYGB PYGL	2.19e-04	6	88	2	CID004602095
Drug	DNPP	PYGB PYGL	2.19e-04	6	88	2	CID000067056
Drug	5-chloro-indole-2-carboxylic acid	PYGB PYGL	2.19e-04	6	88	2	CID000082693
Drug	2,2-dimethyl-3-hydroxybutyric acid	PYGB PYGL	2.19e-04	6	88	2	CID000152984
Drug	EdUMP	PYGB PYGL	2.19e-04	6	88	2	CID003085112
Drug	5'-deoxy-5'-chloroformycin	PYGB PYGL	2.19e-04	6	88	2	CID000126430
Drug	NSC-97433	PYGB PYGL	2.19e-04	6	88	2	CID000001803
Drug	5-n-propylthioadenosine	PYGB PYGL	2.19e-04	6	88	2	CID000656428
Drug	AzddCyd	PYGB PYGL	2.19e-04	6	88	2	CID000451374
Drug	BAY R3401	PYGB PYGL	2.19e-04	6	88	2	CID009842599
Drug	5-Ffdru	PYGB PYGL	2.19e-04	6	88	2	CID000065561
Drug	AR-L57	PYGB PYGL	2.19e-04	6	88	2	CID000156890
Drug	Carbocyclic Ivdu	PYGB PYGL	2.19e-04	6	88	2	CID006439191
Drug	6-hydroxyluteolin	PYGB PYGL	2.19e-04	6	88	2	CID005281642
Drug	brilliant yellow	PYGB PYGL	2.19e-04	6	88	2	CID005462609
Drug	deoxythymidine diphosphate-glucose	PYGB PYGL ARAF	2.80e-04	33	88	3	CID000000684
Drug	nicotinamide ribose	SYNE1 PYGB PYGL ARAF	2.90e-04	82	88	4	CID000000940
Drug	alpha-(fluoromethyl)dehydroornithine	PYGB PYGL	3.06e-04	7	88	2	CID006439607
Drug	2-tetralone	TRIM32 SYNE1	3.06e-04	7	88	2	CID000068266
Drug	6-fluoropyridoxal	PYGB PYGL	3.06e-04	7	88	2	CID003080803
Drug	2',3'-dideoxy-3'-fluorocytidine	PYGB PYGL	3.06e-04	7	88	2	CID000356019
Drug	RG 14467	ERBB3 C4A	3.06e-04	7	88	2	CID000132069
Drug	heptenitol	PYGB PYGL	3.06e-04	7	88	2	CID000188267
Drug	3-methylcytidine	PYGB PYGL	3.06e-04	7	88	2	CID000159649
Disease	Ovarian Mucinous Adenocarcinoma	MYO3A ERBB3 TRRAP	9.44e-05	31	84	3	C1335167
Disease	asphyxiating thoracic dystrophy (is_implicated_in)	NEK1 KIAA0753	1.67e-04	7	84	2	DOID:0050592 (is_implicated_in)
Disease	chronic obstructive pulmonary disease	ERBB3 ZSCAN12 DLC1 KIF1B MAP3K20 ZSCAN9 PPP1R18 DNAH5	7.70e-04	688	84	8	EFO_0000341
Disease	muscular dystrophy (is_implicated_in)	TRIM32 SYNE1	1.06e-03	17	84	2	DOID:9884 (is_implicated_in)
Disease	Nonsyndromic genetic hearing loss	MYO3A OTOF MYH14	1.35e-03	76	84	3	cv:C5680182
Disease	Nasopharyngeal carcinoma	ERBB3 SYNE1	1.78e-03	22	84	2	C2931822
Disease	Ovarian Serous Adenocarcinoma	MYO3A TRRAP	1.95e-03	23	84	2	C1335177
Disease	ergothioneine measurement	RIMS2 DNAH5	2.49e-03	26	84	2	EFO_0021163
Disease	Adenocarcinoma of large intestine	DLC1 TRRAP ARAF	2.63e-03	96	84	3	C1319315

Protein segments in the cluster

Peptide	Gene	Start	Entry
VEEELVGEEQELEAP	ERICH6	56	Q7L0X2
EEVELEPELDLDLDL	ERBB3	1001	P21860
LDDDIPLLEVEEEPV	DISP3	666	Q9P2K9
LLLPLSTENGEEEEE	BIRC6	4411	Q9NR09
QELELELEGPLLEAD	CTC1	316	Q2NKJ3
LQEEDLIDEDDIPVR	C4B	761	P0C0L5
EEEEEVDPRIQGELE	SH3BP5	36	O60239
LLEDDLGQLSDLEPE	ARHGEF11	696	O15085
LNELEEILDVIEPSE	PPP2R5D	381	Q14738
AEEELLPGVDVLLEV	CUEDC2	141	Q9H467
IIGEEDLPSEEVDQE	BPNT1	71	O95861
ELNLEPEEENELLQL	FAM200A	466	Q8TCP9
EEPIEEELLLQQIDN	RBSN	731	Q9H1K0
DIGKIDVQEPELEDL	RGPD5	406	Q99666
DIGKIDVQEPELEDL	RGPD8	406	O14715
VDVDLLLGEIDPDQA	GOPC	46	Q9HD26
PADLAGLEDEDVIIE	PDZK1	411	Q5T2W1
IPVQELVLEDLQDGD	NET1	431	Q7Z628
DDDTLDLGEVELVEP	ARIH1	36	Q9Y4X5
EDEEPALEELEQREV	ARL10	66	Q8N8L6
DLVPVEVSDLEEELE	GNL2	546	Q13823
GLEDLIDALDILEEE	MAGEB10	21	Q96LZ2
EPIPEEQELDFQGLE	GIGYF1	321	O75420
NLEEPDDLETEILQE	NEK1	891	Q96PY6
ELELEVDDPLLVELQ	MAPK8IP1	506	Q9UQF2
QGLGDIIDIDPLIDD	KIF1B	386	O60333
DELELDVDDPVLVEA	MAPK8IP2	621	Q13387
PIILEGLDLVEEDDQ	CWC22	351	Q9HCG8
AELQEPLLQLEDEAE	CCDC178	581	Q5BJE1
LEGRLGQLEEELEEE	MYH14	1751	Q7Z406
LQENLDGEILDDEIL	CUL7	516	Q14999
PDIGDLLDQLVEEIT	PI4KA	1706	P42356
LEELEQEQEPEPHLL	DBN1	566	Q16643
RDPLALIEELEQEEG	NUTM1	446	Q86Y26
EILIELETALLDDEP	RIMS2	911	Q9UQ26
QLEEDLQEDEVPLIA	PLA2G4E	361	Q3MJ16
DIGNIDVQEPELEDL	RGPD3	406	A6NKT7
LDGEELIVEVLEDVP	ARAF	81	P10398
PEELTILGETQEEED	CLCN6	26	P51797
ILGETQEEEDEILPR	CLCN6	31	P51797
EEEEIPNEIREDDLP	IGSF11	276	Q5DX21
EFLLDVLEDPVELIE	CASQ1	151	P31415
VLEDPVELIEGEREL	CASQ1	156	P31415
ELEVLEELIVLLDPE	IGFLR1	256	Q9H665
EEGLEEDAELLTELQ	CC2D1B	96	Q5T0F9
GVPEDLSLEEREELL	CYTH3	11	O43739
PEQLESGEEELVLAE	DDX12P	206	Q92771
GEPEENEEKIVNLEL	MAP3K20	426	Q9NYL2
DDEEDEEELLLLQPE	PPP1R18	581	Q6NYC8
LELLEEETEPGVPEE	SAMD15	181	Q9P1V8
QELLDEAELELELEP	FAM167B	121	Q9BTA0
LQEEDLIDEDDIPVR	C4A	761	P0C0L4
DVGEELDPALDNVLE	DNAH5	3651	Q8TE73
LELLVEESPEEVVED	LRRC43	371	Q8N309
DEDDIEGNLLLPEGV	OTOF	396	Q9HC10
VPLEEDDELEEEEII	TAF3	156	Q5VWG9
EVELDPDIQLEDIAE	KATNAL1	396	Q9BW62
DIGNIDVQEPELEDL	RGPD4	406	Q7Z3J3
EEELLPLEKEEVEVA	TRMT1L	6	Q7Z2T5
VALLEETADEEEPEL	TRIM32	251	Q13049
AQEGLEEKGDPEELL	SYNE1	946	Q8NF91
LDPNDENLILEIPDE	TAF1L	521	Q8IZX4
LAGELPEELEQEHLD	FAM178B	146	Q8IXR5
LQEDQLGEDELAELE	NBEAL2	1891	Q6ZNJ1
QPVDLGLLEEDDEFE	SEM1	6	P60896
PIGNELEEDLEILEE	MYCBP2	2181	O75592
LPLQLELEEEEEEAG	RNF217	101	Q8TC41
ELDVLDADIVLEEGP	KIAA0753	456	Q2KHM9
DLENEDIFPELDDIL	DLC1	896	Q96QB1
QEEEIPELEIDVDEL	PPP1R14B	86	Q96C90
EQELGIAQLLDPEDV	SPTBN5	246	Q9NRC6
EIIEIPDEDDDVLSI	SETDB1	121	Q15047
LEELELVESPGLEEE	CLCN1	951	P35523
EPLEAIQLELDPEED	PRPF8	186	Q6P2Q9
IQLELDPEEDAPVLD	PRPF8	191	Q6P2Q9
IVEPLEQLDDEDGLP	SFPQ	446	P23246
EDLPEVELVSLLEEQ	TRAK2	36	O60296
LLQPGILGDDEEEEE	PIK3R5	311	Q8WYR1
LEAEPIELVETAGDE	RNF4	31	P78317
LGLDLEELEEIEEDA	PYGB	116	P11216
EEGGTEDVEELLVPD	UTP14A	346	Q9BVJ6
LDDILTEVPEQDDEL	YTHDC1	16	Q96MU7
DLSLPELLDEEDVLQ	PPP6R1	21	Q9UPN7
EVELEGLEPQDLEAS	ZBTB10	66	Q96DT7
LLEDLERELDEPQHE	ZSCAN9	126	O15535
PEDGELIDQSEEGLI	ZNF407	1366	Q9C0G0
LGLDIEELEEIEEDA	PYGL	116	P06737
LEDLERELDEPGEQV	ZSCAN12	121	O43309
EEDVEIDIELAPGDQ	TRRAP	2556	Q9Y4A5
ELDESLEDPETGEVI	ATP6V0A2	206	Q9Y487
ILDPIHDIDEEIEAE	MYO3A	51	Q8NEV4