Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	tRNA (cytidine-3-)-methyltransferase activity	METTL2A METTL2B	1.15e-04	4	88	2	GO:0052735
MousePheno	mosaic coat color	ATP7A OCA2	2.47e-05	2	70	2	MP:0010389
Domain	Ig_C2-set	CD4 VCAM1	6.27e-05	3	86	2	IPR008424
Domain	C2-set	CD4 VCAM1	6.27e-05	3	86	2	PF05790
Domain	MeTrfase	METTL2A METTL2B	1.25e-04	4	86	2	IPR026113
Domain	Methyltransf_12	METTL2A METTL2B	3.11e-04	6	86	2	PF08242
Domain	Methyltransf_12	METTL2A METTL2B	3.11e-04	6	86	2	IPR013217
Domain	TPR-like_helical_dom	NPHP3 TMTC3 WDR35 BBS4 TTC17 TRAPPC8	7.23e-04	233	86	6	IPR011990
Domain	TPR_1	NPHP3 TMTC3 BBS4 TTC17	7.92e-04	90	86	4	PF00515
Domain	TPR_1	NPHP3 TMTC3 BBS4 TTC17	7.92e-04	90	86	4	IPR001440
Domain	ARM-type_fold	DOCK5 USP34 SMG1 PSME4 PIK3CA USP9Y TEX10	9.61e-04	339	86	7	IPR016024
Domain	TF_fork_head_CS_2	FOXJ2 FOXN3 FOXI1	1.24e-03	46	86	3	IPR030456
Domain	TF_fork_head_CS_1	FOXJ2 FOXN3 FOXI1	1.32e-03	47	86	3	IPR018122
Domain	COS_domain	FSD1L FSD1	1.34e-03	12	86	2	IPR017903
Domain	COS	FSD1L FSD1	1.34e-03	12	86	2	PS51262
Domain	FH	FOXJ2 FOXN3 FOXI1	1.49e-03	49	86	3	SM00339
Domain	FORK_HEAD_1	FOXJ2 FOXN3 FOXI1	1.49e-03	49	86	3	PS00657
Domain	FORK_HEAD_2	FOXJ2 FOXN3 FOXI1	1.49e-03	49	86	3	PS00658
Domain	Fork_head_dom	FOXJ2 FOXN3 FOXI1	1.49e-03	49	86	3	IPR001766
Domain	FORK_HEAD_3	FOXJ2 FOXN3 FOXI1	1.49e-03	49	86	3	PS50039
Domain	Forkhead	FOXJ2 FOXN3 FOXI1	1.49e-03	49	86	3	PF00250
Domain	TPR_2	NPHP3 BBS4 TTC17	1.58e-03	50	86	3	PF07719
Domain	TPR_2	NPHP3 BBS4 TTC17	1.58e-03	50	86	3	IPR013105
Domain	TPR_8	TMTC3 BBS4 TTC17	1.87e-03	53	86	3	PF13181
Domain	Bbox_C	FSD1L FSD1	2.12e-03	15	86	2	IPR003649
Domain	BBC	FSD1L FSD1	2.12e-03	15	86	2	SM00502
Domain	PI3/4_kinase_CS	SMG1 PIK3CA	2.12e-03	15	86	2	IPR018936
Domain	-	SMG1 PIK3CA	2.41e-03	16	86	2	1.10.1070.11
Domain	PI3Kc	SMG1 PIK3CA	2.41e-03	16	86	2	SM00146
Domain	-	NPHP3 TMTC3 BBS4 TTC17 TRAPPC8	2.68e-03	207	86	5	1.25.40.10
Domain	TPR	NPHP3 TMTC3 BBS4 TTC17	2.98e-03	129	86	4	SM00028
Domain	PI3/4_kinase_cat_dom	SMG1 PIK3CA	3.06e-03	18	86	2	IPR000403
Domain	PI3_PI4_kinase	SMG1 PIK3CA	3.06e-03	18	86	2	PF00454
Domain	PI3_4_KINASE_3	SMG1 PIK3CA	3.06e-03	18	86	2	PS50290
Domain	PI3_4_KINASE_1	SMG1 PIK3CA	3.06e-03	18	86	2	PS00915
Domain	PI3_4_KINASE_2	SMG1 PIK3CA	3.06e-03	18	86	2	PS00916
Domain	TPR_repeat	NPHP3 TMTC3 BBS4 TTC17	3.33e-03	133	86	4	IPR019734
Domain	VWC_out	VWF JAG1	3.41e-03	19	86	2	SM00215
Domain	USP_CS	USP34 USP8 USP9Y	3.50e-03	66	86	3	IPR018200
Domain	HEAT_REPEAT	SMG1 PSME4 TEX10	4.13e-03	70	86	3	PS50077
Domain	USP_1	USP34 USP8 USP9Y	4.13e-03	70	86	3	PS00972
Domain	UCH	USP34 USP8 USP9Y	4.30e-03	71	86	3	PF00443
Domain	USP_2	USP34 USP8 USP9Y	4.30e-03	71	86	3	PS00973
Domain	USP_3	USP34 USP8 USP9Y	4.47e-03	72	86	3	PS50235
Domain	USP_dom	USP34 USP8 USP9Y	4.47e-03	72	86	3	IPR028889
Domain	Peptidase_C19_UCH	USP34 USP8 USP9Y	4.47e-03	72	86	3	IPR001394
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	TRPM6 PCNP USP34 FAM184B RHOH NPHP3 SLC4A7 PSME4 PTPRR CEP112 ANAPC15 UNC5C VPS35L BBS4 DNA2	8.75e-08	1084	88	15	11544199
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	MAPK8IP1 USP34 USP8 FRY VWF RABEP1 PDE4DIP VPS35L PPP1R16B TTC17 MYNN USP9Y RPH3A CNOT3 ZMYM5	7.61e-07	1285	88	15	35914814
Pubmed	Organization of the human beta-adducin gene (ADD2).	RPH3A ADD2	6.33e-06	2	88	2	9244430
Pubmed	Rabphilin-3A binds to a M(r) 115,000 polypeptide in a phosphatidylserine- and Ca(2+)-dependent manner.	RPH3A ADD2	6.33e-06	2	88	2	7707875
Pubmed	[Markers of endothelial dysfunction (VCAM-1 and vWF) in chronic hepatitis C].	VWF VCAM1	6.33e-06	2	88	2	24640675
Pubmed	Identification as beta-adducin of a protein interacting with rabphilin-3A in the presence of Ca2+ and phosphatidylserine.	RPH3A ADD2	6.33e-06	2	88	2	7999065
Pubmed	Endothelial damage in major depression patients is modulated by SSRI treatment, as demonstrated by circulating biomarkers and an in vitro cell model.	VWF VCAM1	6.33e-06	2	88	2	27598970
Pubmed	Identification of PTPRR and JAG1 as key genes in castration-resistant prostate cancer by integrated bioinformatics methods.	PTPRR JAG1	6.33e-06	2	88	2	32133801
Pubmed	Potent Antineoplastic Effects of Combined PI3Kα-MNK Inhibition in Medulloblastoma.	ATP7A PIK3CA	6.33e-06	2	88	2	30842251
Pubmed	Characterization of human FSD1, a novel brain specific gene on chromosome 19 with paralogy to 9q31.	FSD1L FSD1	6.33e-06	2	88	2	11267680
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	DOCK5 TMTC3 DDX60 XRN1 SMARCA2 TTC17	1.30e-05	202	88	6	33005030
Pubmed	CD4+ T cells migrate into inflamed skin only if they express ligands for E- and P-selectin.	CD4 OCA2	1.90e-05	3	88	2	9670976
Pubmed	The Inositol Polyphosphate 5-Phosphatase PIPP Regulates AKT1-Dependent Breast Cancer Growth and Metastasis.	PIK3CA INPP5J	1.90e-05	3	88	2	26267533
Pubmed	DALRD3 encodes a protein mutated in epileptic encephalopathy that targets arginine tRNAs for 3-methylcytosine modification.	METTL2A METTL2B	1.90e-05	3	88	2	32427860
Pubmed	Alström Syndrome protein ALMS1 localizes to basal bodies of cochlear hair cells and regulates cilium-dependent planar cell polarity.	ALMS1 BBS4	1.90e-05	3	88	2	21071598
Pubmed	The XRN1-regulated RNA helicase activity of YTHDC2 ensures mouse fertility independently of m6A recognition.	XRN1 YTHDC2	1.90e-05	3	88	2	35305312
Pubmed	Basal body proteins regulate Notch signaling through endosomal trafficking.	ALMS1 BBS4	1.90e-05	3	88	2	24681783
Pubmed	Regulation of m6A Transcripts by the 3'→5' RNA Helicase YTHDC2 Is Essential for a Successful Meiotic Program in the Mammalian Germline.	XRN1 YTHDC2	1.90e-05	3	88	2	29033321
Pubmed	Candidate gene analysis in primary lymphedema.	FOXJ2 VCAM1 FOXI1	3.46e-05	25	88	3	18564921
Pubmed	Identification of a novel family of putative methyltransferases that interact with human and Drosophila presenilins.	METTL2A METTL2B	3.79e-05	4	88	2	11738826
Pubmed	Tumor-intrinsic PIK3CA represses tumor immunogenecity in a model of pancreatic cancer.	CD4 PIK3CA	3.79e-05	4	88	2	31112530
Pubmed	Mutually exclusive substrate selection strategy by human m3C RNA transferases METTL2A and METTL6.	METTL2A METTL2B	3.79e-05	4	88	2	34268557
Pubmed	Gp120 activates children's brain endothelial cells via CD4.	CD4 VCAM1	3.79e-05	4	88	2	11517385
Pubmed	Three distinct 3-methylcytidine (m3C) methyltransferases modify tRNA and mRNA in mice and humans.	METTL2A METTL2B	6.30e-05	5	88	2	28655767
Pubmed	Phosphatidylinositol (PI) 3-kinase and PI 4-kinase binding to the CD4-p56lck complex: the p56lck SH3 domain binds to PI 3-kinase but not PI 4-kinase.	CD4 PIK3CA	6.30e-05	5	88	2	8246987
Pubmed	Histone Acetyltransferase KAT6A Upregulates PI3K/AKT Signaling through TRIM24 Binding.	PIK3CA KAT6A	6.30e-05	5	88	2	29021135
Pubmed	Residual Cajal bodies in coilin knockout mice fail to recruit Sm snRNPs and SMN, the spinal muscular atrophy gene product.	GEMIN2 COIL	9.43e-05	6	88	2	11470819
Pubmed	Increased serum vWF and sVCAM-1 levels are associated with late or very late angiographic stent thrombosis after sirolimus-eluting stent implantation.	VWF VCAM1	9.43e-05	6	88	2	20508517
Pubmed	Hyper-SUMOylation of SMN induced by SENP2 deficiency decreases its stability and leads to spinal muscular atrophy-like pathology.	GEMIN2 COIL	9.43e-05	6	88	2	34628513
Pubmed	Genetic predictors of depressive symptoms in cardiac patients.	VWF VCAM1	9.43e-05	6	88	2	18618671
Pubmed	A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.	USP8 SLC4A7 ATP7A PIK3CA UNC5C PRKCSH ADD2	9.90e-05	421	88	7	36976175
Pubmed	Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.	FSD1L ATP7A ZNF180 KAT6A PDE4DIP VPS35L CELA2A PRKCSH FOXN3 TEX10 METTL2A METTL2B	1.00e-04	1293	88	12	15342556
Pubmed	Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.	KIF27 PSME4 SMARCA2 TTC17 TRAPPC8 TEX10	1.26e-04	304	88	6	32235678
Pubmed	Expanding roles for alpha 4 integrin and its ligands in development.	VWF VCAM1	1.32e-04	7	88	2	7526952
Pubmed	The primary cilium as the cell's antenna: signaling at a sensory organelle.	KIF27 BBS4	1.32e-04	7	88	2	16888132
Pubmed	Molecular basis for hematopoietic/mesenchymal interaction during initiation of Peyer's patch organogenesis.	CD4 VCAM1	1.32e-04	7	88	2	11238592
Pubmed	Heat stable antigen (mouse CD24) supports myeloid cell binding to endothelial and platelet P-selectin.	VWF VCAM1	1.75e-04	8	88	2	8562500
Pubmed	HIV-1 and recombinant gp120 affect the survival and differentiation of human vessel wall-derived mesenchymal stem cells.	CD4 VWF	1.75e-04	8	88	2	21612582
Pubmed	A tissue-specific, Gata6-driven transcriptional program instructs remodeling of the mature arterial tree.	JAG1 CNN1	1.75e-04	8	88	2	28952437
Pubmed	Testosterone levels influence mouse fetal Leydig cell progenitors through notch signaling.	JAG1 VCAM1	1.75e-04	8	88	2	23467742
Pubmed	Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development.	VWF JAG1	1.75e-04	8	88	2	18245384
Pubmed	Ectopic lymphoid-organ development occurs through interleukin 7-mediated enhanced survival of lymphoid-tissue-inducer cells.	CD4 VCAM1	1.75e-04	8	88	2	17521585
Pubmed	Microfibril-associated glycoprotein-2 interacts with fibrillin-1 and fibrillin-2 suggesting a role for MAGP-2 in elastic fiber assembly.	VWF JAG1	2.25e-04	9	88	2	12122015
Pubmed	Maternal retinoids control type 3 innate lymphoid cells and set the offspring immunity.	CD4 VCAM1	2.25e-04	9	88	2	24670648
Pubmed	Interaction of TAGLN and USP1 promotes ZEB1 ubiquitination degradation in UV-induced skin photoaging.	USP34 USP9Y	2.25e-04	9	88	2	37149635
Pubmed	HENA, heterogeneous network-based data set for Alzheimer's disease.	MAPK8IP1 ALMS1 ZNF180 PDE4DIP	2.51e-04	120	88	4	31413325
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	SMG1 NPHP3 CTTNBP2 VWF ALMS1 RABEP1 PDE4DIP	2.73e-04	497	88	7	23414517
Pubmed	Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.	USP34 SMG1 ALMS1 PPP1R16B WDR35	2.74e-04	225	88	5	12168954
Pubmed	The Foxn1-dependent transcripts PCOLCE2 and mPPP1R16B are not required for normal thymopoiesis.	CD4 PPP1R16B	2.81e-04	10	88	2	17683113
Pubmed	Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay.	SMG1 XRN1	2.81e-04	10	88	2	18423202
Pubmed	The ubiquitin-specific protease USP8 is critical for the development and homeostasis of T cells.	USP8 CD4	2.81e-04	10	88	2	26214742
Pubmed	The nuclear localization pattern and interaction partners of GTF2IRD1 demonstrate a role in chromatin regulation.	ALMS1 BBS4 ZMYM5	2.81e-04	50	88	3	26275350
Pubmed	Identification of motif-based interactions between SARS-CoV-2 protein domains and human peptide ligands pinpoint antiviral targets.	ALMS1 MZB1 PDE4DIP PCDH11X YTHDC2	3.22e-04	233	88	5	37704626
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	USP8 DLG5 SLC4A7 ALMS1 CEP112 RABEP1 XRN1 FSD1 WNK3	3.34e-04	861	88	9	36931259
Pubmed	Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity.	VWF JAG1	3.43e-04	11	88	2	15875024
Pubmed	Lack of pendrin expression leads to deafness and expansion of the endolymphatic compartment in inner ears of Foxi1 null mutant mice.	JAG1 FOXI1	3.43e-04	11	88	2	12642503
Pubmed	Separation of splenic red and white pulp occurs before birth in a LTalphabeta-independent manner.	CD4 VCAM1	3.43e-04	11	88	2	18403646
Pubmed	Tamalin is a scaffold protein that interacts with multiple neuronal proteins in distinct modes of protein-protein association.	FRY PRKCSH	3.43e-04	11	88	2	12586822
Pubmed	An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells.	CD4 VCAM1	3.43e-04	11	88	2	14691482
Pubmed	STING Gain-of-Function Disrupts Lymph Node Organogenesis and Innate Lymphoid Cell Development in Mice.	CD4 VCAM1	3.43e-04	11	88	2	32553167
Pubmed	Homeodomain factor Nkx2-3 controls regional expression of leukocyte homing coreceptor MAdCAM-1 in specialized endothelial cells of the viscera.	CD4 CNN1 VCAM1	3.73e-04	55	88	3	10926756
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	DLG5 ALMS1 GEMIN2 XRN1 YTHDC2	3.83e-04	242	88	5	34011540
Pubmed	HIV-1 Nef plays an essential role in two independent processes in CD4 down-regulation: dissociation of the CD4-p56(lck) complex and targeting of CD4 to lysosomes.	CD4 PIK3CA	4.11e-04	12	88	2	10208934
Pubmed	Innervation of the developing kidney in vivo and in vitro.	JAG1 CNN1	4.11e-04	12	88	2	37439314
Pubmed	Impaired lymphoid organ development in mice lacking the heparan sulfate modifying enzyme glucuronyl C5-epimerase.	CD4 VCAM1	4.11e-04	12	88	2	20208005
Pubmed	Redundant roles of Sox17 and Sox18 in postnatal angiogenesis in mice.	VWF VCAM1	4.11e-04	12	88	2	16895970
Pubmed	A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins.	SMG1 ATP7A TMTC3 GEMIN2 TTC17 PRKCSH TRAPPC8 ADD2	4.82e-04	719	88	8	35337019
Pubmed	NANOS2 interacts with the CCR4-NOT deadenylation complex and leads to suppression of specific RNAs.	XRN1 CNOT3	4.85e-04	13	88	2	20133598
Pubmed	Identification of IL-7-producing cells in primary and secondary lymphoid organs using IL-7-GFP knock-in mice.	CD4 VCAM1	4.85e-04	13	88	2	22786774
Pubmed	HIV-1 Nef in macrophage-mediated disease pathogenesis.	CD4 PIK3CA	4.85e-04	13	88	2	23215766
Pubmed	Inhibition of notch1-dependent cardiomyogenesis leads to a dilated myopathy in the neonatal heart.	VWF JAG1	4.85e-04	13	88	2	20558824
Pubmed	Transcription factor TFCP2L1 patterns cells in the mouse kidney collecting ducts.	JAG1 FOXI1	4.85e-04	13	88	2	28577314
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	USP34 USP8 SLC4A7 ALMS1 TMTC3 CENPE XRN1 TTC17	5.47e-04	733	88	8	34672954
Pubmed	LTbetaR signaling induces cytokine expression and up-regulates lymphangiogenic factors in lymph node anlagen.	CD4 VCAM1	5.65e-04	14	88	2	19380791
Pubmed	Overexpression of RhoH Permits to Bypass the Pre-TCR Checkpoint.	RHOH CD4	5.65e-04	14	88	2	26114424
Pubmed	Hindbrain rhombic lip is comprised of discrete progenitor cell populations allocated by Pax6.	UNC5C RPH3A	5.65e-04	14	88	2	16364898
Pubmed	Chemokine coreceptor signaling in HIV-1 infection and pathogenesis.	CD4 PIK3CA	5.65e-04	14	88	2	20041213
Pubmed	Deubiquitinating enzymes: a new class of biological regulators.	USP8 USP9Y	6.51e-04	15	88	2	9827704
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	USP34 ALMS1 GEMIN2 RABEP1 XRN1 ZMYM5	6.87e-04	418	88	6	34709266
Pubmed	Tie2 regulates endocardial sprouting and myocardial trabeculation.	VWF JAG1 VCAM1	6.97e-04	68	88	3	31112136
Pubmed	Proximity labeling reveals OTUD3 as a DNA-binding deubiquitinase of cGAS.	TMTC3 VPS35L WDR35	6.97e-04	68	88	3	36966392
Pubmed	Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability.	USP34 DLG5 ALMS1 CENPE RABEP1 ZNF180 CNOT3	7.42e-04	588	88	7	38580884
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	MAPK8IP1 FRY CTTNBP2 CENPE RABEP1 PDE4DIP TEX10 RPH3A WNK3	7.46e-04	963	88	9	28671696
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	DOCK5 USP34 SLC4A7 ATP7A ZBED6 UNC5C XRN1 COIL	7.99e-04	777	88	8	35844135
Pubmed	A Brg1 mutation that uncouples ATPase activity from chromatin remodeling reveals an essential role for SWI/SNF-related complexes in beta-globin expression and erythroid development.	CD4 SMARCA2	8.40e-04	17	88	2	16287714
Pubmed	Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation.	CD4 VCAM1	8.40e-04	17	88	2	19783990
Pubmed	Macrophage activation through CCR5- and CXCR4-mediated gp120-elicited signaling pathways.	CD4 PIK3CA	8.40e-04	17	88	2	12960231
Pubmed	A strategy for modulation of enzymes in the ubiquitin system.	USP8 USP9Y	8.40e-04	17	88	2	23287719
Pubmed	The RNA helicase DHX34 activates NMD by promoting a transition from the surveillance to the decay-inducing complex.	SMG1 XRN1	9.43e-04	18	88	2	25220460
Pubmed	Lymphatic Endothelial Cells Control Initiation of Lymph Node Organogenesis.	CD4 VCAM1	9.43e-04	18	88	2	28709801
Pubmed	Unravelling the complex genetics of cleft lip in the mouse model.	METTL2A METTL2B	1.05e-03	19	88	2	11353389
Pubmed	Ubiquitous and kidney-specific subunits of vacuolar H+-ATPase are differentially expressed during nephrogenesis.	ATP6V1C1 FOXI1	1.05e-03	19	88	2	16177003
Pubmed	Lymph sacs are not required for the initiation of lymph node formation.	CD4 VCAM1	1.05e-03	19	88	2	19060331
Pubmed	COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.	ATP7A VPS35L	1.05e-03	19	88	2	25355947
Pubmed	Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes.	CD4 SMARCA2	1.05e-03	19	88	2	12110891
Pubmed	Synapsin and synaptic vesicle protein expression during embryonic and post-natal lens fiber cell differentiation.	MAPK8IP1 RABEP1	1.05e-03	19	88	2	15529118
Pubmed	Origin and differentiation trajectories of fibroblastic reticular cells in the splenic white pulp.	CD4 CNN1	1.17e-03	20	88	2	30988302
Pubmed	The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis.	VWF VCAM1	1.17e-03	20	88	2	23426945
Pubmed	A novel common variant in DCST2 is associated with length in early life and height in adulthood.	TTC17 GSDMC	1.17e-03	20	88	2	25281659
Pubmed	Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.	TAS1R1 GSDMC	1.17e-03	20	88	2	21738478
GeneFamily	Forkhead boxes	FOXJ2 FOXN3 FOXI1	3.35e-04	43	57	3	508
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	NPHP3 TMTC3 BBS4 TTC17	4.73e-04	115	57	4	769
GeneFamily	Ubiquitin specific peptidases	USP34 USP8 USP9Y	7.31e-04	56	57	3	366
ToppCell	10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	LRRC8C USP34 SMG1 RHOH KAT6A SMARCA2 USP9Y	3.42e-08	162	88	7	b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-6m-Mesenchymal-Cilia-bearing_cell\|6m / Sample Type, Dataset, Time_group, and Cell type.	SPEF1 KIF27 ART3 CCDC65 JHY ZBBX LRRC9	1.45e-07	200	88	7	177f9ad8dd8635394c575a2b30140184df0bd51e
ToppCell	LV-13._Vascular_Smooth_Muscle\|LV / Chamber and Cluster_Paper	FRY JAG1 UNC5C CELA2A OCA2 CNN1	1.16e-06	171	88	6	e99ecae66530d1ae09330cee408c8f3950b87e67
ToppCell	COVID_non-vent-Lymphocytic-T_cell-CD4+_Memory_T_cell\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	RTKN2 RHOH CD4 DDX60 PDE4DIP UBALD2	2.48e-06	195	88	6	22191d361af136942508f1553ff41a626ed982ad
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	USP34 SMG1 RTKN2 SLC4A7 XRN1 SMARCA2	2.63e-06	197	88	6	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	TCGA-Skin-Metastatic-Melanoma\|TCGA-Skin / Sample_Type by Project: Shred V9	USP34 CD4 ALMS1 PIK3CA KAT6A VCAM1	2.70e-06	198	88	6	af4fb9eb2295c7b90624b38ba25619aa15254efa
ToppCell	TCGA-Skin-Metastatic\|TCGA-Skin / Sample_Type by Project: Shred V9	USP34 CD4 ALMS1 PIK3CA KAT6A VCAM1	2.70e-06	198	88	6	ad39cce004867f083f8da1954e0cf5a263815184
ToppCell	TCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma\|TCGA-Skin / Sample_Type by Project: Shred V9	USP34 CD4 ALMS1 PIK3CA KAT6A VCAM1	2.70e-06	198	88	6	62cbf4b29e8af4983fb47a17f96da62682a5137e
ToppCell	ICU-NoSEP-Lymphocyte-T_NK-Treg\|ICU-NoSEP / Disease, Lineage and Cell Type	MAPK8IP1 RTKN2 RHOH SLC4A7 USP9Y	1.60e-05	159	88	5	d065ec02a4f3672ba53d4fea66029f1ce68f367f
ToppCell	droplet-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	TRPM6 VWF ART3 PPP1R16B VCAM1	2.03e-05	167	88	5	774f3264318b002d0df5d06d41d645366038d0bf
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FAM184B FOXN3 WNK3 FOXI1 LRRC9	2.40e-05	173	88	5	0bc2aacae60c6d3276b0949eb0748b4ac1f56e54
ToppCell	droplet-Heart-4Chambers-18m-Endothelial-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ENGASE RTKN2 PPP1R16B DNA2	2.57e-05	86	88	4	d20ec61a572b11641647358a546334b217c694f3
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DLG5 FOXN3 WNK3 FOXI1 LRRC9	2.61e-05	176	88	5	6c7edf1cb38644500bce6c5a1dd90bbe17415cdb
ToppCell	facs-Lung-Endomucin-3m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF PTPRR JAG1 PPP1R16B VCAM1	2.75e-05	178	88	5	5cc182e6faa7ba5b88378d2c953be29bbbb95a7e
ToppCell	facs-Lung-Endomucin-3m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF PTPRR JAG1 PPP1R16B VCAM1	2.75e-05	178	88	5	f9a16bc3f09c35c7d30e3809da024bc2dcf746ed
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW19-Neuronal-GABAergic_neurons\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	PTPRR PDE4DIP PCDH11X RPH3A	2.81e-05	88	88	4	5582fd7bac60c690ecd1f2aff1d446ccb69f79b9
ToppCell	Ciliated_cells-B-Donor_06\|World / lung cells shred on cell class, cell subclass, sample id	MAPK8IP1 SPEF1 OCA2 CCDC65 ZBBX	2.90e-05	180	88	5	bdea5ec6b60fc8c7cce4d71db5da74ac8675e211
ToppCell	facs-Lung-24m-Hematologic-myeloid-myeloid_dendritic_cell-dendritic_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLC41A2 ALMS1 DDX60 ZNF180 UNC5C	2.90e-05	180	88	5	d33bb00f2b7d07dda9015cb8eafd742c2b2e9ace
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FRY CTTNBP2 UNC5C OCA2 VCAM1	2.98e-05	181	88	5	5f2d3a08577c440c944778d07aa993c6e7873f3d
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FRY CTTNBP2 UNC5C OCA2 VCAM1	2.98e-05	181	88	5	c7c5f7d4c397b4613c772413a0a679377efffff3
ToppCell	COVID-19-kidney-Podocyte\|kidney / Disease (COVID-19 only), tissue and cell type	DOCK5 FRY CTTNBP2 UNC5C PDE4DIP	3.14e-05	183	88	5	fb5e2a31b560126e1c04a386c24c365901c60ad7
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 FAM184B FRY UNC5C PDE4DIP	3.14e-05	183	88	5	3c516fe5083f02bad1f464ed284010b4131a833c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 FRY CTTNBP2 UNC5C OCA2	3.14e-05	183	88	5	848fc6dd129150897ee339343e83c645b6e779eb
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 FAM184B FRY UNC5C PDE4DIP	3.14e-05	183	88	5	9c2689d76fc6d30f5ab093428aa669d0a98953cf
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Renal_corpuscle_epithelial_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 FAM184B FRY UNC5C PDE4DIP	3.22e-05	184	88	5	7294b379ce4cb8fa75e432559082f93cd106aaf5
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 FRY CTTNBP2 UNC5C PDE4DIP	3.31e-05	185	88	5	9197f074e769d54031ec41abfc65fcc0c6552c7e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FRY CTTNBP2 UNC5C OCA2 VCAM1	3.31e-05	185	88	5	34fcfd635c828dad9643bbf1c908d79282d6f5d9
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 FRY CTTNBP2 UNC5C PDE4DIP	3.31e-05	185	88	5	ce7d62394b09c26ca65b8cdb280afec5e25bbb62
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK5 FRY CTTNBP2 UNC5C PDE4DIP	3.31e-05	185	88	5	b848b63aff4d9dbb9e66a85876d4c7c6dacd0579
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FRY CTTNBP2 UNC5C OCA2 VCAM1	3.31e-05	185	88	5	8816f2909ed11833ff3d0ed96b9cb6d6fe9e1578
ToppCell	PCW_05-06-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)\|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung	RTKN2 CENPE OCA2 DNA2 CNN1	3.76e-05	190	88	5	e83fa8b711aa79a1767818474f1c193b674b1c31
ToppCell	LPS-antiTNF-Endothelial-Endothelial-Artery\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	LRRC8C CTTNBP2 VWF JAG1 PPP1R16B	3.85e-05	191	88	5	4b3d5157344dbfbf4fab518611cd9fa37fac7bd9
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-lymphocytic-innate_lymphocytic-mature_NK_T_cell\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DOCK5 DLG5 FRY SMARCA2 FSD1	3.95e-05	192	88	5	df4741e7684f010445f0224a1fd61aaa4fae02b3
ToppCell	COPD-Lymphoid-T\|World / Disease state, Lineage and Cell class	LRRC8C RHOH SLC4A7 SMARCA2 PPP1R16B	3.95e-05	192	88	5	eb4909574fb5fc91399463523e2737095773200a
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like-ILC3\|lymph-node_spleen / Manually curated celltypes from each tissue	DOCK5 DLG5 FRY JAG1 UNC5C	3.95e-05	192	88	5	e16035b3328f9b1b2e28d234c62ba88387540550
ToppCell	IPF-Lymphoid-T\|World / Disease state, Lineage and Cell class	LRRC8C RHOH SLC4A7 SMARCA2 PPP1R16B	3.95e-05	192	88	5	b25ba1f3bc842c22602b2aeed3b1b5082863e4fa
ToppCell	Control-Lymphoid-T\|Control / Disease state, Lineage and Cell class	LRRC8C RHOH SLC4A7 SMARCA2 PPP1R16B	4.05e-05	193	88	5	af928046ccd1ca874be1534aef6ca7f27d90bc46
ToppCell	severe-low-quality_cells\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SMG1 RTKN2 SLC4A7 TMTC3 USP9Y	4.05e-05	193	88	5	9337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell	nucseq-Immune-Lymphocytic_T/NK-Lymphocytic_T/NK-CD4_T\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	LRRC8C RHOH SLC4A7 SMARCA2 PPP1R16B	4.05e-05	193	88	5	9c9434a3297b85774b4f0ecab6294f44d738e29f
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27\|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)	MZB1 PIK3CA WDR35 FOXN3 CCDC191	4.15e-05	194	88	5	d852aebf7a763b9a776c4570711f0c759f591910
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Immune\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	RHOH CD4 MZB1 PPP1R16B FOXN3	4.15e-05	194	88	5	4dfc890bacf133cfb6ec7c8b73f084f2491cf78e
ToppCell	10x_3'_v3-lymph_node_(10x_3'_v3)-lymphocytic-innate_lymphocytic-innate_lymphoid_cell\|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	DOCK5 RTKN2 FRY SMARCA2 FSD1	4.25e-05	195	88	5	d70b49f6b9c6c4422adb2936c837a1af7569fb0a
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_neuro-secretory\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	ATP7A CELA2A ZNF709 INPP5J FOXI1	4.36e-05	196	88	5	a4cc02ea41479d24044bd2ca6441f85d683c0ca9
ToppCell	IPF-Lymphoid-T\|Lymphoid / Disease state, Lineage and Cell class	LRRC8C RHOH CD4 SLC4A7 SMARCA2	4.36e-05	196	88	5	6e70c48a63d9673eb16b0847c1bd88eecc2f7a3c
ToppCell	COVID_non-vent-Lymphocytic\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	SMG1 RHOH MZB1 PPP1R16B USP9Y	4.46e-05	197	88	5	c672915f8c8c1e948d251f6eaf9f84a5600c1193
ToppCell	Tracheal-10x5prime-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	RTKN2 NPHP3 CELA2A ZNF709 FOXI1	4.46e-05	197	88	5	fd76cc5e12c7e7943a48f739e4f0626ff7211f51
ToppCell	COVID-19_Mild\|World / Disease group, lineage and cell class	SMG1 DDX60 XRN1 UBALD2 FOXN3	4.46e-05	197	88	5	5c33454b10023decd2f5ccda9229b6512659711e
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class (2021.03.09)	SMG1 DDX60 XRN1 UBALD2 FOXN3	4.57e-05	198	88	5	44417089b62056269cac38d3134ff209c05b7007
ToppCell	Sepsis-ICU-NoSEP-Lymphocyte-T/NK-Treg\|ICU-NoSEP / Disease, condition lineage and cell class	MAPK8IP1 RTKN2 RHOH SLC4A7 USP9Y	4.57e-05	198	88	5	1ed4dfe5565328cb0f7ef31e6b2f67dfbdf3e2ac
ToppCell	PBMC-Mild\|PBMC / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SMG1 DDX60 XRN1 UBALD2 FOXN3	4.57e-05	198	88	5	28ef3fc4c17dcb765537b75917f7db78baa522db
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW23\|fetalBrain_Zhong_nature / Sample Type, Dataset, Time_group, and Cell type.	RHOH PTPRR PDE4DIP USP9Y RPH3A	4.68e-05	199	88	5	f30e9d3d095a1e12d759debe27540aad32861db6
ToppCell	(07)_Ionocytes\|World / shred by cell type by condition	SLC4A7 VWF ATP7A TMTC3 FOXI1	4.68e-05	199	88	5	8194777d367405a7840787e977854b5c07e3bd6b
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Mesenchymal-Cilia-bearing_cell\|3m / Sample Type, Dataset, Time_group, and Cell type.	SPEF1 CCDC65 JHY ZBBX LRRC9	4.79e-05	200	88	5	0d14a950172a56b11fdebee8f4e13b0c10e0d592
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23\|organoid_Tanaka_cellReport / Sample Type, Dataset, Time_group, and Cell type.	RHOH PTPRR PDE4DIP USP9Y RPH3A	4.79e-05	200	88	5	e16bde12326f0cfc4d03f9307cba0e21ea2389cb
ToppCell	LPS_only-Endothelial-Endothelial-Artery\|LPS_only / Treatment groups by lineage, cell group, cell type	FRY CTTNBP2 VWF JAG1 SMARCA2	4.79e-05	200	88	5	b17eb1587ca86c3d40515128a00a8d8fd787fccf
ToppCell	Fetal_brain-fetalBrain_Zhong_nature-GW23-Neuronal-GABAergic_neurons\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	MAPK8IP1 PTPRR PDE4DIP PCDH11X RPH3A	4.79e-05	200	88	5	c6bbd33bca86ac7a76a7ba704b3e141237d04549
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW19-Neuronal-Interneuron\|GW19 / Sample Type, Dataset, Time_group, and Cell type.	PTPRR UBALD2 RPH3A CNN1	9.75e-05	121	88	4	b2d571f571133c281d72584fe925cebbd2317829
ToppCell	Ionocyte-iono-4\|World / Class top	DOCK5 MYNN CNN1 VCAM1	1.25e-04	129	88	4	85ee6e16959cb58a58f5b09edf1f78d9ce6a9441
ToppCell	TCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Chromophobe-9\|TCGA-Kidney / Sample_Type by Project: Shred V9	FAM184B GSDMC INPP5J FOXI1	1.66e-04	139	88	4	a93b861906d7f01ff715084f99152ec83529f8b3
ToppCell	TCGA-Kidney-Primary_Tumor-Renal_Cell_Carcinoma-Kidney_Chromophobe\|TCGA-Kidney / Sample_Type by Project: Shred V9	FAM184B GSDMC INPP5J FOXI1	1.71e-04	140	88	4	bc5bed94c33129391ca35791febb55cc4cdff989
ToppCell	E18.5-samps-Mesenchymal-Myofibroblast-MyoFB-1\|E18.5-samps / Age Group, Lineage, Cell class and subclass	KIF27 MZB1 CCDC65 ZBBX	1.96e-04	145	88	4	ac41c6c02b7d78162b86222983688f54d04ac47d
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1\|Striatum / BrainAtlas - Mouse McCarroll V32	CD4 KIF27 ZNF180 OCA2	2.01e-04	146	88	4	7b863f9bc63dc1afe015a18a70cd6ed0b71d1f09
ToppCell	3'-GW_trimst-1.5-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CTTNBP2 UNC5C PDE4DIP OCA2	2.17e-04	149	88	4	aedbae2dffa1e880e5c6a146b6d5a135e7f54308
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_G2M\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VWF CENPE PTPRR JAG1	2.52e-04	155	88	4	8e239470799426ea474a36f57e1b7e0d9365ca5f
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CTTNBP2 UNC5C OCA2 VCAM1	2.59e-04	156	88	4	dd41ed918b07fa248da458a629b3c53cb7ea8764
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	CTTNBP2 UNC5C OCA2 VCAM1	2.59e-04	156	88	4	abf9dd075b1ca8f613c660cc82f8a5af071fb6ab
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW23-Neuronal-Interneuron\|GW23 / Sample Type, Dataset, Time_group, and Cell type.	PTPRR PDE4DIP RPH3A	2.64e-04	63	88	3	c10d344bf32a091deb79e1f128f7dd5e9f4abaa3
ToppCell	NS-moderate-d_07-13-Epithelial-FOXN4+\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	KIF27 ALMS1 CEP112 ZBBX	2.65e-04	157	88	4	410c9d74a2085179cfb39853cb6d330fa98c9c1b
ToppCell	Severe-B_naive-5\|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)	RTKN2 SPDYA FSD1 ADD2	2.65e-04	157	88	4	a57ee4a6febdff3ee3d1645836695e6e7c055cf8
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	FAM184B INPP5J FOXI1 LRRC9	2.85e-04	160	88	4	174a4ab27114efcc63be36929b80680be3c35c9b
ToppCell	RV-13._Vascular_Smooth_Muscle\|World / Chamber and Cluster_Paper	FRY JAG1 OCA2 CNN1	2.85e-04	160	88	4	29c9b4770d0e73d59cffc7937b179484c76b6dcc
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Connecting_Tubule_Intercalated_Cell_Type_A\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TRPM6 FSD1 WNK3 FOXI1	2.85e-04	160	88	4	86fde32f096eaf9ea3677f57169cdcc0a57bb8dd
ToppCell	10x3'2.3-week_12-13-Lymphocytic_B-B_lineage-naive_B_cell\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	VWF MZB1 XRN1 WDR35	2.85e-04	160	88	4	bfbac5ed3273b4430314c6c25cdc1bf0c42b27a1
ToppCell	Mild-MAIT\|Mild / Disease group and Cell class	FRY SPEF1 FSD1 ZBBX	2.92e-04	161	88	4	0c1a04485708d5302600cdc2d7dac1cb76b4033a
ToppCell	Children_(3_yrs)-Immune-dendritic_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SLC41A2 CD4 MZB1 PPP1R16B	2.98e-04	162	88	4	86a0b9dabd150dc993bfc0f3344804de7f8e4042
ToppCell	Mild-Lymphoid-NK-innate_T\|Mild / Condition, Lineage, Cell class and cell subclass	FOXJ2 RTKN2 WDR35 METTL2B	2.98e-04	162	88	4	bd218e41b2eadc3bba4c7ac3e34a014f6ad8b1bf
ToppCell	facs-Lung-ENDOMUCIN-18m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAPK8IP1 CD4 ALMS1 TEX10	3.06e-04	163	88	4	4af92b211d12c5b88b65bb746242cd702b545bd0
ToppCell	saliva-Severe-critical_progression_d28-40-Myeloid-Granulocytic-Neutrophil-Neu_c5-GSTP1(high)OASL(low)\|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)	DLG5 XRN1 YTHDC2 GSDMC	3.06e-04	163	88	4	d005115aa1e1458b51de7eb719794617a4168608
ToppCell	343B-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_0\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	FRY SLC4A7 SPDYA VCAM1	3.06e-04	163	88	4	0ab043b68e8739adcedda01165a3758cd0d22728
ToppCell	facs-Lung-ENDOMUCIN-18m-Lymphocytic-CD4+_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAPK8IP1 CD4 ALMS1 TEX10	3.06e-04	163	88	4	d24774e0aa612322c22fdb3b314aef275fa01d68
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	FAM184B INPP5J FOXI1 LRRC9	3.13e-04	164	88	4	d847d509bb1791638032ade6755d8164586b5bd5
ToppCell	343B-Myeloid-Dendritic-cDC_activated\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	SLC41A2 FAM184B FSD1 VCAM1	3.13e-04	164	88	4	eae6d440877b292ad18dc4bd02802dda5b2f9c60
ToppCell	PCW_07-8.5-Epithelial-Epithelial_ciliated-epi_ciliated_(14)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	SPEF1 GSDMC ZBBX LRRC9	3.20e-04	165	88	4	0c714e852f912b5749de4cb0895406673979b2e6
ToppCell	PCW_07-8.5-Epithelial-Epithelial_ciliated\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	SPEF1 GSDMC ZBBX LRRC9	3.20e-04	165	88	4	82530f96aaefe28a13bad0474bbad043f127a86c
ToppCell	tumor_Lymph_Node_/_Brain-T/NK_cells-Exhausted_Tfh\|tumor_Lymph_Node_/_Brain / Location, Cell class and cell subclass	LRRC8C RHOH CD4 SMARCA2	3.27e-04	166	88	4	c73fce59256ad501864f44f76cfae2fc33b3777e
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VWF PTPRR TAS1R1 VCAM1	3.35e-04	167	88	4	f01b96173deda0239fa482989873cf308e49d48c
ToppCell	PND28-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	VWF PTPRR TAS1R1 VCAM1	3.35e-04	167	88	4	5fc85a05124cd2324e1b8ff940193880f83cd8af
ToppCell	facs-GAT-Fat-18m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|GAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RHOH CD4 PPP1R16B UBALD2	3.43e-04	168	88	4	28248e97165b0f0a272aed62f7d3898472992e15
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c12-FOXP3\|Severe-critical_progression_d12-22 / Compartment, severity and other cell annotations on 10x 3' data (130k)	CD4 ZBED6 DDX60 JAG1	3.50e-04	169	88	4	c8691c4f707d46b2865fe46eabe24ea4d03c7b43
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	VWF JAG1 PCDH11X INPP5J	3.50e-04	169	88	4	c7fc3a8c44f07c557b60d469717b66e2f5863d38
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FAM184B FOXN3 FOXI1 LRRC9	3.50e-04	169	88	4	2a21f2cef959526bfe3c8f081f4f7e9dd4e01a37
ToppCell	facs-Lung-18m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell-CD4-positive,_alpha-beta_T_cell_l21\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MAPK8IP1 CD4 ALMS1 TEX10	3.58e-04	170	88	4	bda900c836e0f2c1d7b442beb50b672d025b2420
ToppCell	Immune-dendritic_cell\|World / Lineage, Cell type, age group and donor	SLC41A2 CD4 MZB1 PPP1R16B	3.66e-04	171	88	4	6a9e2e2d3e1d8cc475bf9765129bc4a32da3b8ea
ToppCell	Adult-Mesenchymal-vascular_smooth_muscle_cell\|Adult / Lineage, Cell type, age group and donor	ART3 JAG1 UNC5C CNN1	3.75e-04	172	88	4	c62cad0f4212d1e9ea1ec3143ad3c4e06aff0ebf
ToppCell	356C-Myeloid-Monocyte-CD16+_Monocyte\|Monocyte / Donor, Lineage, Cell class and subclass (all cells)	FSD1L GEMIN2 YTHDC2 METTL2B	3.75e-04	172	88	4	9dca1542145d88559527db7e0f6ad150df59ca2d
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Mesenchymal-brain_pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC4A7 ART3 JAG1 TAS1R1	3.83e-04	173	88	4	2415b6ff49f334da570577d4e93484d024a3dbd5
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Mesenchymal-Pericyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC4A7 ART3 JAG1 TAS1R1	3.83e-04	173	88	4	2acd0693a2dfe04e3c1b2125ea63efe92d13150b
ToppCell	PND01-03-samps-Endothelial-Postnatal_endothelial-capillary_endothelial_Hpgd-CA4_high\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	LRRC8C CTTNBP2 VWF PPP1R16B	3.91e-04	174	88	4	cb0109661e8c9ca04d67d33f2d926f0e649bf67d
ToppCell	facs-Marrow-B-cells-18m-Lymphocytic-early_pro-B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MZB1 ADAM21 PCDH11X PPP1R16B	3.91e-04	174	88	4	268be5e7d2a18b866770b7cdb966c3958c7e6534
ToppCell	facs-Brain_Non-Myeloid-Cortex-24m-Lymphocytic-T_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RHOH MZB1 CELA2A OCA2	3.91e-04	174	88	4	723848d2f8ae9cf4f15d4b4a130f9a64dab443c7
Drug	Vincristine	LRRC8C USP34 FSD1L FRY SLC4A7 VWF ATP7A PSME4 ALMS1 MZB1 PTPRR DDX60 YTHDC2 UBALD2 DNA2 CNOT3 VCAM1	2.39e-06	1182	88	17	ctd:D014750
Drug	Demecolcine	USP34 FRY SLC4A7 PSME4 ALMS1 MZB1 PTPRR DDX60 YTHDC2 UBALD2 MYNN DNA2 VCAM1 ZMYM5	6.57e-06	878	88	14	ctd:D003703
Drug	Apigenin [520-36-5]; Down 200; 14.8uM; HL60; HT_HG-U133A	FRY SLC4A7 PSME4 ALMS1 GEMIN2 JAG1 SMARCA2	7.34e-06	184	88	7	1321_DN
Drug	Tiaprofenic acid [33005-95-7]; Up 200; 15.4uM; MCF7; HT_HG-U133A	DOCK5 USP34 ATP6V1C1 SLC4A7 ALMS1 PDE4DIP RPH3A	1.00e-05	193	88	7	2852_UP
Drug	Pyrantel tartrate [33401-94-4]; Up 200; 11.2uM; HL60; HG-U133A	USP34 RHOH ATP6V1C1 FRY PPP1R16B YTHDC2 RPH3A	1.04e-05	194	88	7	1413_UP
Drug	Idoxuridine [54-42-2]; Up 200; 11.2uM; PC3; HT_HG-U133A	PTPRR CEP112 RABEP1 YTHDC2 INPP5J ZMYM5 JHY	1.04e-05	194	88	7	4200_UP
Drug	Carbetapentane citrate [23142-01-0]; Down 200; 7.6uM; PC3; HT_HG-U133A	ATP6V1C1 RABEP1 PDE4DIP SMARCA2 YTHDC2 FSD1 CNOT3	1.22e-05	199	88	7	4649_DN
Disease	Adenoid Cystic Carcinoma	PIK3CA JAG1 KAT6A SMARCA2	2.04e-04	100	85	4	C0010606
Disease	spinal muscular atrophy (implicated_via_orthology)	ATP7A GEMIN2	2.91e-04	9	85	2	DOID:12377 (implicated_via_orthology)
Disease	Polydactyly	NPHP3 ALMS1 PIK3CA BBS4	3.71e-04	117	85	4	C0152427
Disease	Moyamoya Disease	ATP7A JAG1	1.08e-03	17	85	2	C0026654
Disease	carotid artery disease (is_marker_for)	VWF VCAM1	1.36e-03	19	85	2	DOID:3407 (is_marker_for)
Disease	Seckel syndrome	CENPE DNA2	1.82e-03	22	85	2	C0265202
Disease	Deafness	JAG1 FOXI1	2.36e-03	25	85	2	C0011053
Disease	antiphospholipid antibody measurement	CEP112 CNN1	2.36e-03	25	85	2	EFO_0005200
Disease	uterine fibroid	DOCK5 SLC4A7 PTPRR MYNN	2.65e-03	199	85	4	EFO_0000731
Disease	DNA methylation	FAM184B FRY ALMS1 SMARCA2 OCA2 JHY ZBBX	2.87e-03	656	85	7	GO_0006306

Protein segments in the cluster

Peptide	Gene	Start	Entry
EAAKLNQKDWEISHN	BBS4	126	Q96RK4
QHQAWLQSIAEKDNN	ANAPC15	36	P60006
QWKQISLSQLQHDAA	ADAM21	281	Q9UKJ8
EHNSALNLNKINTQW	CCDC65	51	Q8IXS2
AILKKLQQDSNHAWF	GSDMC	376	Q9BYG8
NNSHFKVWNSLQLKS	ALMS1	2636	Q8TCU4
LNNDWEKKLHNAVAE	CEP112	351	Q8N8E3
VVHKDWNSNQISKGN	CELA2A	106	P08217
NLLWEKNVRNKDNHC	CBWD5	296	Q5RIA9
EDIWQKLHNAANANQ	CNOT3	26	O75175
HKNNWNIEDNNIKNA	ATP7A	1131	Q04656
DKNWETNIQELQKKH	OCA2	601	Q04671
QQHNQLKHTWQKAND	RABEP1	271	Q15276
DLSWNQLKKSGNEIN	LRRC9	766	Q6ZRR7
EKLENLKWASFSNNN	LRRC9	906	Q6ZRR7
DKWHQRAQQLKNYQE	JHY	316	Q6NUN7
NVNKHRSHWKSQQLD	GEMIN2	116	O14893
TLNNNSLGKKHSWQD	MAPK8IP1	176	Q9UQF2
NNWLQVSFTAKHANK	FSD1	396	Q9BTV5
NWLQNTFAAKHNNKV	FSD1L	426	Q9BXM9
KEQHQKLWEEQLAAA	PRKCSH	191	P14314
EDWQSQKAKLQAQVS	FAM184B	596	Q9ULE4
HQIFSWKNKQNIKDA	DDX60	196	Q8IY21
NLLWEKNVRNKDNHC	CBWD2	296	Q8IUF1
NLLWEKNVRNKDNHC	CBWD1	296	Q9BRT8
LNEKQQHKLQEWFNM	KIF27	431	Q86VH2
SDNQKLWERNIKSHL	PCNP	156	Q8WW12
SQNQNHLKDWFLENK	METTL2B	106	Q6P1Q9
KHWKSRENNNNNEKV	COIL	131	P38432
HELNKATAQNKDLQW	DLG5	381	Q8TDM6
NLDSWNVKEIHQAAD	MYNN	86	Q9NPC7
AEQKNWTLDQHHIAN	FOXJ2	451	Q9P0K8
HLKAAQKNKQNSEWA	PCDH11X	841	Q9BZA7
QFNSHTLHQWLKDKN	PIK3CA	871	P42336
SQNQNHLKDWFLENK	METTL2A	106	Q96IZ6
NVLQGQHEADKIWSK	PTPRR	211	Q15256
LSHGANVNAKDNELW	PPP1R16B	121	Q96T49
RNHGKLDNKQNVDWN	KAT6A	86	Q92794
LNWRSNSQNIKHNLK	DOCK5	641	Q9H7D0
INNNSKEVNWNLHKN	CTTNBP2	1641	Q8WZ74
TNLNWLHESKNLLKS	FOXN3	61	O00409
KKNLQLAEAQWAAEH	CCDC191	581	Q8NCU4
NLLWEKNVRNKDNHC	CBWD3	296	Q5JTY5
NLLWEKNVRNKDNHC	CBWD6	296	Q4V339
FHWKNSNQIKILGNQ	CD4	51	P01730
QSGQLKWQDELNQHN	ENGASE	276	Q8NFI3
WHIFLNNCLSNLKNK	FRY	381	Q5TBA9
NKSKAGWQNSIRHNL	FOXI1	161	Q12951
ESQSKDNKKNHQNIW	DNA2	451	P51530
NNQHLSNEVKTWKER	CENPE	2576	Q02224
TKHPNWTNKQDNRDL	JAG1	1191	P78504
LKSQSNTDQLVKDNW	RTKN2	516	Q8IZC4
QQTWEKLHAATSKNN	ATP6V1C1	16	P21283
DNWQAFEKNTHNNNK	SPDYA	41	Q5MJ70
IFWSKKLDNGNLQHL	VCAM1	256	P19320
DKKIERWHQLQNENH	RPH3A	676	Q9Y2J0
NETLAQWKKDNITAH	SLC4A7	776	Q9Y6M7
TNLVWEHKQAQAAKE	SMARCA2	541	P51531
WLFQQQGSKQKLHDC	NPHP3	871	Q7Z494
ANHNSFLNLKNKWIG	RHOH	86	Q15669
AAVQEWQNAIHDLKK	SMG1	1201	Q96Q15
QKNQEDRHKKANGIW	SLC41A2	51	Q96JW4
QHAQKQQKEKTRWLN	ADD2	421	P35612
WVIKLHQDLKNPNNS	C12orf4	226	Q9NQ89
SVKKINESTQNWHQL	CNN1	71	P51911
HQLWEKDQLNMAKNT	INPP5J	626	Q15735
LNQSLKDAWASDQKV	VPS35L	191	Q7Z3J2
LKQSQEDLSKNSLWN	TRPM6	1661	Q9BX84
LNINETKIQWHGKDN	TAS1R1	476	Q7RTX1
NAWKLHGDCQDLQKQ	VWF	551	P04275
SLQQKLSNWGHLNRK	SPEF1	61	Q9Y4P9
HLGDKEQSNWAKEVQ	XRN1	761	Q8IZH2
FINWKEHANDQQHIQ	TEX10	266	Q9NXF1
HKVLNLLWNLAQSDD	USP9Y	506	O00507
SLANILHNAKLWNDA	TTC17	1056	Q96AE7
NWQEHKQQFTDDQLL	PSME4	1816	Q14997
NWEEKNIEDHKNQGR	ZNF709	46	Q8N972
DQAKQLLQAAHWQFE	UBALD2	26	Q8IYN6
KWHLNAAVNSHQKIN	ZNF180	226	Q9UJW8
HLLNPWNDNKKVQIS	YTHDC2	1386	Q9H6S0
NDHQLPWKNLKQDET	ZBED6	631	P86452
NQLKNENGCKDWQHL	ZMYM5	601	Q9UJ78
HWKLQKSVNLSENKD	TRAPPC8	1131	Q9Y2L5
LWNNALAAKAQLSKQ	USP34	471	Q70CQ2
VNKNNAKLWNNVGHA	TMTC3	441	Q6ZXV5
AKLWNNVGHALENEK	TMTC3	446	Q6ZXV5
KAAVDTCVHLNQWNK	WDR35	886	Q9P2L0
NTEDWKILLKNQAAQ	UNC5C	616	O95185
AAEHAWQKHKQLNES	USP8	906	P40818
LSQWRTGNHDDNKKQ	ZBBX	266	A8MT70
DQAKQLLQAAHWQFE	UBALD1	26	Q8TB05
QSQHKLETENWNKVS	WNK3	1676	Q9BYP7
SENKLKQLNLNNEWT	LRRC8C	396	Q8TDW0
ASHQQLDTVWENAKA	ART3	61	Q13508
KQHLDKTWADVENLN	PDE4DIP	66	Q5VU43
SEQQKEASWKHNQEL	PDE4DIP	386	Q5VU43
EASWKHNQELRKALQ	PDE4DIP	391	Q5VU43
WQNLAKAETKLHTSN	MZB1	61	Q8WU39