Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

CACNA1A ANO9 HCN1 PKD1L1 SLC24A3 KCNB2 SLC9A2 SLC10A1 SLC14A1 SLC15A1 KCNJ4 SCN1A SLC22A1 KCNJ9 ATP6V1D SCN4A SCN8A SLC10A6 MFSD5

7.10e-0975810119GO:0015318
GeneOntologyMolecularFunctionmetal ion transmembrane transporter activity

CACNA1A HCN1 PKD1L1 SLC24A3 KCNB2 SLC9A2 SLC10A1 KCNJ4 SCN1A SLC22A1 KCNJ9 SCN4A SCN8A SLC10A6

9.17e-0846510114GO:0046873
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

CACNA1A HCN1 PKD1L1 SLC24A3 KCNB2 SLC9A2 SLC10A1 SLC15A1 KCNJ4 SCN1A SLC22A1 KCNJ9 ATP6V1D SCN4A SCN8A SLC10A6

9.93e-0862710116GO:0022890
GeneOntologyMolecularFunctionchannel inhibitor activity

ANO9 WNK1 SLC15A1 WNK4 WNK3 WNK2

1.91e-07501016GO:0016248
GeneOntologyMolecularFunctionpotassium channel inhibitor activity

WNK1 WNK4 WNK3 WNK2

1.98e-07111014GO:0019870
GeneOntologyMolecularFunctionsodium ion transmembrane transporter activity

HCN1 SLC24A3 SLC9A2 SLC10A1 SCN1A SLC22A1 SCN4A SCN8A SLC10A6

2.13e-071711019GO:0015081
GeneOntologyMolecularFunctiontransporter inhibitor activity

ANO9 WNK1 SLC15A1 WNK4 WNK3 WNK2

2.16e-07511016GO:0141110
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

CACNA1A HCN1 PKD1L1 SLC24A3 KCNB2 SLC9A2 SLC10A1 SLC15A1 KCNJ4 SCN1A SLC22A1 KCNJ9 ATP6V1D SCN4A SCN8A SLC10A6

2.16e-0766410116GO:0008324
GeneOntologyMolecularFunctionolfactory receptor activity

OR13C8 OR13C3 OR13F1 OR4C45 OR2S2 OR52P1 OR13C6P OR2T6 OR13C9 OR13C2 OR6Y1 OR13C7 OR2W6P

2.69e-0743110113GO:0004984
GeneOntologyMolecularFunctiontransmembrane transporter activity

CACNA1A ANO9 HCN1 PKD1L1 SLC24A3 KCNB2 SLC2A2 ABCG1 SLC9A2 SLC10A1 SLC14A1 SLC15A1 KCNJ4 SCN1A SLC22A1 KCNJ9 ATP6V1D SCN4A SCN8A SLC10A6 MFSD5

3.68e-07118010121GO:0022857
GeneOntologyMolecularFunctiontransporter activity

NPC1 CACNA1A ANO9 HCN1 PKD1L1 SLC24A3 KCNB2 SLC2A2 ABCG1 SLC9A2 SLC10A1 SLC14A1 SLC15A1 KCNJ4 SCN1A SLC22A1 KCNJ9 ATP6V1D SCN4A SCN8A SLC10A6 MFSD5

3.75e-07128910122GO:0005215
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

CACNA1A ANO9 HCN1 PKD1L1 SLC24A3 KCNB2 SLC9A2 SLC10A1 SLC15A1 KCNJ4 SCN1A SLC22A1 KCNJ9 ATP6V1D SCN4A SCN8A SLC10A6

4.49e-0779310117GO:0015075
GeneOntologyMolecularFunctionion channel inhibitor activity

ANO9 WNK1 WNK4 WNK3 WNK2

4.32e-06481015GO:0008200
GeneOntologyMolecularFunctionvoltage-gated sodium channel activity

HCN1 SCN1A SCN4A SCN8A

8.46e-06261014GO:0005248
GeneOntologyMolecularFunctionmonoatomic cation channel activity

CACNA1A HCN1 PKD1L1 SLC24A3 KCNB2 KCNJ4 SCN1A KCNJ9 SCN4A SCN8A

9.44e-0634310110GO:0005261
GeneOntologyMolecularFunctionpotassium channel regulator activity

DRD4 WNK1 WNK4 WNK3 WNK2

1.02e-05571015GO:0015459
GeneOntologyMolecularFunctionchannel activity

CACNA1A ANO9 HCN1 PKD1L1 SLC24A3 KCNB2 SLC14A1 KCNJ4 SCN1A KCNJ9 SCN4A SCN8A

1.37e-0552510112GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

CACNA1A ANO9 HCN1 PKD1L1 SLC24A3 KCNB2 SLC14A1 KCNJ4 SCN1A KCNJ9 SCN4A SCN8A

1.40e-0552610112GO:0022803
GeneOntologyMolecularFunctionmonoatomic ion channel activity

CACNA1A ANO9 HCN1 PKD1L1 SLC24A3 KCNB2 KCNJ4 SCN1A KCNJ9 SCN4A SCN8A

2.08e-0545910111GO:0005216
GeneOntologyMolecularFunctionchannel regulator activity

ANO9 DRD4 WNK1 SLC15A1 WNK4 WNK3 WNK2

2.92e-051741017GO:0016247
GeneOntologyMolecularFunctiontransporter regulator activity

ANO9 DRD4 WNK1 SLC15A1 WNK4 WNK3 WNK2

3.26e-051771017GO:0141108
GeneOntologyMolecularFunctionG protein-coupled receptor activity

DRD4 OR13C8 OR13C3 OR13F1 OR4C45 OR2S2 OR52P1 GRM5 OR13C6P OR2T6 OR13C9 OR13C2 OR6Y1 OR13C7 OR2W6P

3.70e-0588410115GO:0004930
GeneOntologyMolecularFunctionsodium channel activity

HCN1 SCN1A SCN4A SCN8A

1.39e-04521014GO:0005272
GeneOntologyMolecularFunctionion channel regulator activity

ANO9 DRD4 WNK1 WNK4 WNK3 WNK2

1.74e-041621016GO:0099106
GeneOntologyMolecularFunctionpotassium ion transmembrane transporter activity

HCN1 SLC24A3 KCNB2 SLC9A2 KCNJ4 KCNJ9

2.06e-041671016GO:0015079
GeneOntologyMolecularFunctionmolecular function inhibitor activity

ANO9 GBP1 WNK1 SERPINB6 SLC15A1 FNIP1 TESC IGSF1 WNK4 WNK3 WNK2

2.14e-0459610111GO:0140678
GeneOntologyMolecularFunctionalkali metal ion binding

ACAT1 SCN1A SCN8A

3.00e-04261013GO:0031420
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

CACNA1A HCN1 KCNB2 KCNJ4 SCN1A KCNJ9

3.27e-041821016GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

CACNA1A HCN1 KCNB2 KCNJ4 SCN1A KCNJ9

3.46e-041841016GO:0022832
GeneOntologyMolecularFunctionbile acid:sodium symporter activity

SLC10A1 SLC10A6

3.75e-0461012GO:0008508
GeneOntologyMolecularFunctionacetyl-CoA C-acetyltransferase activity

ACAT1 HADHB

3.75e-0461012GO:0003985
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

NPC1 DRD4 GFRAL OR13C8 OR13C3 OR13F1 OR4C45 OR2S2 OR52P1 GRM5 OR13C6P OR2T6 OR13C9 OR13C2 OR6Y1 OR13C7 OR2W6P

4.23e-04135310117GO:0004888
GeneOntologyMolecularFunctionorganic hydroxy compound transmembrane transporter activity

ABCG1 SLC10A1 SLC22A1 SLC10A6

4.38e-04701014GO:1901618
GeneOntologyMolecularFunctionlipid transporter activity

NPC1 ANO9 ABCG1 SLC10A1 SLC22A1 SLC10A6

4.85e-041961016GO:0005319
GeneOntologyMolecularFunctionlipid transmembrane transporter activity

ABCG1 SLC10A1 SLC22A1 SLC10A6

5.14e-04731014GO:0170055
GeneOntologyMolecularFunctionC-acetyltransferase activity

ACAT1 HADHB

5.23e-0471012GO:0016453
GeneOntologyMolecularFunctionacetyl-CoA C-acyltransferase activity

ACAT1 HADHB

5.23e-0471012GO:0003988
GeneOntologyMolecularFunctionactive monoatomic ion transmembrane transporter activity

SLC24A3 SLC9A2 SLC10A1 SLC15A1 SLC22A1 ATP6V1D SLC10A6

8.47e-043011017GO:0022853
GeneOntologyMolecularFunctionsymporter activity

SLC24A3 SLC10A1 SLC15A1 SLC22A1 SLC10A6

9.93e-041501015GO:0015293
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

CACNA1A HCN1 KCNB2 KCNJ4 KCNJ9

1.05e-031521015GO:0022843
GeneOntologyMolecularFunctionmolecular condensate scaffold activity

NLRP1 WNK1 WNK3

1.25e-03421013GO:0140693
GeneOntologyMolecularFunctiongated channel activity

CACNA1A ANO9 HCN1 KCNB2 KCNJ4 SCN1A KCNJ9

1.54e-033341017GO:0022836
GeneOntologyMolecularFunctiontoxin transmembrane transporter activity

ABCG1 SLC22A1

1.62e-03121012GO:0019534
GeneOntologyMolecularFunctionvoltage-gated potassium channel activity

HCN1 KCNB2 KCNJ4 KCNJ9

1.79e-031021014GO:0005249
GeneOntologyMolecularFunctionsodium ion binding

SCN1A SCN8A

2.22e-03141012GO:0031402
GeneOntologyMolecularFunctionmonocarboxylate:sodium symporter activity

SLC10A1 SLC10A6

2.55e-03151012GO:0140161
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC24A3 ABCG1 SLC9A2 SLC10A1 SLC15A1 SLC22A1 ATP6V1D SLC10A6

2.91e-034771018GO:0022804
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC10A1 SLC15A1 SLC22A1 SLC10A6

3.14e-031191014GO:0015294
GeneOntologyMolecularFunctioncholesterol binding

NPC1 ABCG1 CD81

3.17e-03581013GO:0015485
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC24A3 SLC9A2 SLC10A1 SLC15A1 SLC22A1 SLC10A6

3.94e-032961016GO:0015291
GeneOntologyMolecularFunctionpotassium channel activity

HCN1 KCNB2 KCNJ4 KCNJ9

4.07e-031281014GO:0005267
GeneOntologyMolecularFunctionsecondary active monocarboxylate transmembrane transporter activity

SLC10A1 SLC10A6

4.10e-03191012GO:0015355
GeneOntologyMolecularFunctionsolute:potassium antiporter activity

SLC24A3 SLC9A2

4.10e-03191012GO:0022821
GeneOntologyMolecularFunctionC-acyltransferase activity

ACAT1 HADHB

5.00e-03211012GO:0016408
GeneOntologyMolecularFunctionenzyme regulator activity

STXBP5L SH3BP1 GBP1 NLRP1 GRM5 WNK1 RCC2 DENND4C CCNE1 SERPINB6 FNIP1 GNA11 TESC HERC2 HERC1

5.02e-03141810115GO:0030234
GeneOntologyMolecularFunction3',5'-cyclic-AMP phosphodiesterase activity

PDE6A PDE11A

5.48e-03221012GO:0004115
GeneOntologyMolecularFunctionsterol binding

NPC1 ABCG1 CD81

5.60e-03711013GO:0032934
GeneOntologyMolecularFunction3',5'-cyclic-GMP phosphodiesterase activity

PDE6A PDE11A

6.50e-03241012GO:0047555
GeneOntologyBiologicalProcesssodium ion transport

DRD4 HCN1 SLC24A3 WNK1 SLC9A2 SLC10A1 SCN1A SCN4A SCN8A SLC10A6 TESC WNK4 WNK3 WNK2

7.34e-1127510114GO:0006814
GeneOntologyBiologicalProcesssodium ion transmembrane transport

DRD4 HCN1 SLC24A3 WNK1 SLC9A2 SCN1A SCN4A SCN8A TESC WNK4 WNK3 WNK2

4.37e-1020810112GO:0035725
GeneOntologyBiologicalProcessmonoatomic cation transmembrane transport

CACNA1A DRD4 HCN1 PKD1L1 SLC24A3 KCNB2 WNK1 SLC9A2 SLC15A1 KCNJ4 SCN1A SLC22A1 KCNJ9 ATP6V1D SCN4A SCN8A TESC OGA WNK4 WNK3 WNK2

4.56e-0994210121GO:0098655
GeneOntologyBiologicalProcessmonoatomic cation transport

CACNA1A DRD4 HCN1 PKD1L1 SLC24A3 KCNB2 WNK1 SLC9A2 SLC10A1 SLC15A1 KCNJ4 SCN1A SLC22A1 KCNJ9 ATP6V1D SCN4A SCN8A SLC10A6 TESC OGA WNK4 WNK3 WNK2

6.48e-09115710123GO:0006812
GeneOntologyBiologicalProcessmonoatomic ion transport

CACNA1A ANO9 DRD4 HCN1 PKD1L1 SLC24A3 KCNB2 WNK1 SLC9A2 SLC10A1 SLC15A1 KCNJ4 SCN1A SLC22A1 KCNJ9 ATP6V1D SCN4A SCN8A SLC10A6 TESC OGA MFSD5 WNK4 WNK3 WNK2

7.37e-09137410125GO:0006811
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

CACNA1A ANO9 DRD4 HCN1 PKD1L1 SLC24A3 KCNB2 WNK1 SLC9A2 SLC15A1 KCNJ4 SCN1A SLC22A1 KCNJ9 ATP6V1D SCN4A SCN8A TESC OGA WNK4 WNK3 WNK2

1.69e-08111510122GO:0034220
GeneOntologyBiologicalProcessinorganic ion transmembrane transport

CACNA1A ANO9 DRD4 HCN1 PKD1L1 SLC24A3 KCNB2 WNK1 SLC9A2 SLC15A1 KCNJ4 SCN1A KCNJ9 ATP6V1D SCN4A SCN8A TESC OGA WNK4 WNK3 WNK2

1.74e-08101710121GO:0098660
GeneOntologyBiologicalProcessinorganic cation transmembrane transport

CACNA1A DRD4 HCN1 PKD1L1 SLC24A3 KCNB2 WNK1 SLC9A2 SLC15A1 KCNJ4 SCN1A KCNJ9 ATP6V1D SCN4A SCN8A TESC OGA WNK4 WNK3 WNK2

1.78e-0892210120GO:0098662
GeneOntologyBiologicalProcesspositive regulation of potassium ion import across plasma membrane

WNK1 WNK4 WNK3 WNK2

1.87e-0871014GO:1903288
GeneOntologyBiologicalProcessregulation of potassium ion import

WNK1 WNK4 WNK3 WNK2

6.70e-0891014GO:1903286
GeneOntologyBiologicalProcessmetal ion transport

CACNA1A DRD4 HCN1 PKD1L1 SLC24A3 KCNB2 WNK1 SLC9A2 SLC10A1 KCNJ4 SCN1A KCNJ9 SCN4A SCN8A SLC10A6 TESC OGA WNK4 WNK3 WNK2

6.79e-08100010120GO:0030001
GeneOntologyBiologicalProcesspotassium ion transport

HCN1 SLC24A3 KCNB2 WNK1 SLC9A2 KCNJ4 KCNJ9 SCN4A WNK4 WNK3 WNK2

9.54e-0827210111GO:0006813
GeneOntologyBiologicalProcesspotassium ion import across plasma membrane

WNK1 KCNJ4 KCNJ9 WNK4 WNK3 WNK2

1.79e-07511016GO:1990573
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception of smell

OR13C8 OR13C3 OR13F1 OR4C45 OR2S2 OR52P1 OR13C6P OR2T6 OR13C9 OR13C2 OR6Y1 OR13C7 OR2W6P

1.91e-0743210113GO:0050911
GeneOntologyBiologicalProcesspotassium ion transmembrane transport

HCN1 SLC24A3 KCNB2 WNK1 SLC9A2 KCNJ4 KCNJ9 WNK4 WNK3 WNK2

2.10e-0723210110GO:0071805
GeneOntologyBiologicalProcessdetection of stimulus

OR13C8 OR13C3 OR13F1 PKD1L1 OR4C45 OR2S2 OR52P1 OR13C6P OR2T6 OR13C9 SCN1A OR13C2 OR6Y1 GNA11 OR13C7 OR2W6P

4.31e-0772210116GO:0051606
GeneOntologyBiologicalProcesssensory perception of smell

OR13C8 OR13C3 OR13F1 OR4C45 OR2S2 OR52P1 OR13C6P OR2T6 OR13C9 OR13C2 OR6Y1 OR13C7 OR2W6P

4.42e-0746510113GO:0007608
GeneOntologyBiologicalProcessinorganic ion import across plasma membrane

CACNA1A WNK1 SLC9A2 KCNJ4 KCNJ9 WNK4 WNK3 WNK2

4.88e-071421018GO:0099587
GeneOntologyBiologicalProcessinorganic cation import across plasma membrane

CACNA1A WNK1 SLC9A2 KCNJ4 KCNJ9 WNK4 WNK3 WNK2

4.88e-071421018GO:0098659
GeneOntologyBiologicalProcessdetection of chemical stimulus involved in sensory perception

OR13C8 OR13C3 OR13F1 OR4C45 OR2S2 OR52P1 OR13C6P OR2T6 OR13C9 OR13C2 OR6Y1 OR13C7 OR2W6P

7.10e-0748510113GO:0050907
GeneOntologyBiologicalProcessdetection of stimulus involved in sensory perception

OR13C8 OR13C3 OR13F1 OR4C45 OR2S2 OR52P1 OR13C6P OR2T6 OR13C9 SCN1A OR13C2 OR6Y1 OR13C7 OR2W6P

9.33e-0758210114GO:0050906
GeneOntologyBiologicalProcesspositive regulation of sodium ion transmembrane transporter activity

DRD4 TESC WNK3 WNK2

9.42e-07161014GO:2000651
GeneOntologyBiologicalProcesssensory perception

PDE6A OR13C8 OR13C3 OR13F1 OR4C45 OR2S2 OR52P1 BBS9 PKHD1L1 OR13C6P SERPINB6 OR2T6 OR13C9 SCN1A OR13C2 SCN8A OR6Y1 OR13C7 OR2W6P

9.58e-07107210119GO:0007600
GeneOntologyBiologicalProcessnegative regulation of pancreatic juice secretion

WNK1 WNK4 WNK3

1.13e-0651013GO:0090188
GeneOntologyBiologicalProcessdetection of chemical stimulus

OR13C8 OR13C3 OR13F1 OR4C45 OR2S2 OR52P1 OR13C6P OR2T6 OR13C9 OR13C2 OR6Y1 OR13C7 OR2W6P

1.68e-0652410113GO:0009593
GeneOntologyBiologicalProcessimport across plasma membrane

CACNA1A WNK1 SLC9A2 SLC15A1 KCNJ4 KCNJ9 WNK4 WNK3 WNK2

1.96e-062301019GO:0098739
GeneOntologyBiologicalProcessmembrane depolarization

CACNA1A HCN1 SCN1A SCN4A SCN8A KMT2A OGA

2.19e-061211017GO:0051899
GeneOntologyBiologicalProcesssensory perception of chemical stimulus

OR13C8 OR13C3 OR13F1 OR4C45 OR2S2 OR52P1 OR13C6P OR2T6 OR13C9 OR13C2 OR6Y1 OR13C7 OR2W6P

2.70e-0654710113GO:0007606
GeneOntologyBiologicalProcessregulation of membrane potential

CACNA1A DRD4 HCN1 RIMS3 KCNB2 GRM5 SCN1A KCNJ9 SCN4A SCN8A KMT2A GNA11 OGA

3.42e-0655910113GO:0042391
GeneOntologyBiologicalProcessnegative regulation of sodium ion transport

WNK1 WNK4 WNK3 WNK2

3.70e-06221014GO:0010766
GeneOntologyBiologicalProcesspositive regulation of sodium ion transmembrane transport

DRD4 TESC WNK3 WNK2

3.70e-06221014GO:1902307
GeneOntologyBiologicalProcessregulation of pancreatic juice secretion

WNK1 WNK4 WNK3

9.37e-0691013GO:0090186
GeneOntologyBiologicalProcessregulation of sodium ion transport

DRD4 WNK1 TESC WNK4 WNK3 WNK2

1.03e-051011016GO:0002028
GeneOntologyBiologicalProcessentrainment of circadian clock

PPP1CA PPP1CB PPP1CC GNA11

1.35e-05301014GO:0009649
GeneOntologyBiologicalProcessnegative regulation of protein localization to plasma membrane

GBP1 WNK1 WNK4 WNK3

1.54e-05311014GO:1903077
GeneOntologyBiologicalProcessnegative regulation of protein localization to cell periphery

GBP1 WNK1 WNK4 WNK3

1.99e-05331014GO:1904376
GeneOntologyBiologicalProcessregulation of sodium ion transmembrane transport

DRD4 WNK1 TESC WNK3 WNK2

2.23e-05691015GO:1902305
GeneOntologyBiologicalProcesspositive regulation of cation transmembrane transport

DRD4 WNK1 TESC OGA WNK4 WNK3 WNK2

2.38e-051741017GO:1904064
GeneOntologyBiologicalProcesscircadian rhythm

DRD4 GFPT1 PPP1CA PPP1CB PPP1CC KMT2A GNA11 PRKDC

3.01e-052481018GO:0007623
GeneOntologyBiologicalProcesscircadian regulation of gene expression

GFPT1 PPP1CA PPP1CB PPP1CC KMT2A

3.35e-05751015GO:0032922
GeneOntologyBiologicalProcesspancreatic juice secretion

WNK1 WNK4 WNK3

3.99e-05141013GO:0030157
GeneOntologyBiologicalProcesspositive regulation of monoatomic ion transmembrane transport

DRD4 WNK1 TESC OGA WNK4 WNK3 WNK2

4.46e-051921017GO:0034767
GeneOntologyBiologicalProcessnegative regulation of protein localization to membrane

GBP1 WNK1 WNK4 WNK3

4.77e-05411014GO:1905476
GeneOntologyBiologicalProcesspositive regulation of sodium ion transport

DRD4 TESC WNK3 WNK2

5.25e-05421014GO:0010765
GeneOntologyBiologicalProcesspositive regulation of potassium ion transmembrane transport

WNK1 WNK4 WNK3 WNK2

5.25e-05421014GO:1901381
GeneOntologyBiologicalProcessregulation of circadian rhythm

DRD4 PPP1CA PPP1CB PPP1CC GNA11 PRKDC

5.35e-051351016GO:0042752
GeneOntologyBiologicalProcessintracellular chloride ion homeostasis

CACNA1A WNK1 WNK4

6.09e-05161013GO:0030644
GeneOntologyBiologicalProcessintracellular monoatomic anion homeostasis

CACNA1A WNK1 WNK4

7.37e-05171013GO:0030002
GeneOntologyBiologicalProcessadult walking behavior

NPC1 CACNA1A SCN1A SCN8A

1.05e-04501014GO:0007628
GeneOntologyBiologicalProcesschemical homeostasis

NPC1 CACNA1A DRD4 STXBP5L SLC24A3 GRM5 WNK1 ADCY5 SLC2A2 ABCG1 SLC9A2 FBN2 ATP6V1D TESC WNK4 WNK3 WNK2

1.12e-04124910117GO:0048878
GeneOntologyBiologicalProcessnegative regulation of digestive system process

WNK1 WNK4 WNK3

1.22e-04201013GO:0060457
GeneOntologyBiologicalProcessG protein-coupled receptor signaling pathway

DRD4 OR13C8 OR13C3 OR13F1 OR4C45 OR2S2 OR52P1 GRM5 WNK1 ADCY5 OR13C6P OR2T6 OR13C9 OR13C2 OR6Y1 GNA11 OR13C7 OR2W6P

1.35e-04139510118GO:0007186
GeneOntologyBiologicalProcessglucan metabolic process

NPC1 GFPT1 PPP1CA PPP1CB PPP1CC

1.39e-041011015GO:0044042
GeneOntologyBiologicalProcessmetanephric proximal tubule development

ACAT1 SLC22A1

1.42e-0441012GO:0072237
GeneOntologyBiologicalProcesspositive regulation of potassium ion transport

WNK1 WNK4 WNK3 WNK2

1.42e-04541014GO:0043268
GeneOntologyBiologicalProcessregulation of secretion

CACNA1A DRD4 STXBP5L RIMS3 WNK1 ADCY5 SLC2A2 ABCG1 SLC10A1 GNA11 OGA WNK4 WNK3

1.44e-0480110113GO:0051046
GeneOntologyBiologicalProcessregulation of sodium ion transmembrane transporter activity

DRD4 TESC WNK3 WNK2

1.75e-04571014GO:2000649
GeneOntologyBiologicalProcessprotein localization to plasma membrane

GBP1 KCNB2 WNK1 DENND4C CD81 TESC WNK4 WNK3

1.94e-043241018GO:0072659
GeneOntologyBiologicalProcessregulation of monoatomic ion transmembrane transport

DRD4 WNK1 KCNJ4 KCNJ9 TESC OGA WNK4 WNK3 WNK2

2.10e-044171019GO:0034765
GeneOntologyBiologicalProcesswalking behavior

NPC1 CACNA1A SCN1A SCN8A

2.14e-04601014GO:0090659
GeneOntologyBiologicalProcesstransmission of nerve impulse

CACNA1A HCN1 SCN1A SCN4A SCN8A

2.26e-041121015GO:0019226
GeneOntologyBiologicalProcessentrainment of circadian clock by photoperiod

PPP1CA PPP1CB PPP1CC

2.42e-04251013GO:0043153
GeneOntologyBiologicalProcesschloride ion homeostasis

CACNA1A WNK1 WNK4

2.42e-04251013GO:0055064
GeneOntologyBiologicalProcessneuronal action potential

HCN1 SCN1A SCN4A SCN8A

2.58e-04631014GO:0019228
GeneOntologyBiologicalProcessadult locomotory behavior

NPC1 CACNA1A DRD4 SCN1A SCN8A

2.66e-041161015GO:0008344
GeneOntologyBiologicalProcesspositive regulation of monoatomic ion transport

DRD4 WNK1 TESC OGA WNK4 WNK3 WNK2

3.36e-042661017GO:0043270
GeneOntologyBiologicalProcessphotoperiodism

PPP1CA PPP1CB PPP1CC

3.42e-04281013GO:0009648
GeneOntologyBiologicalProcessmonoatomic anion homeostasis

CACNA1A WNK1 WNK4

3.42e-04281013GO:0055081
GeneOntologyBiologicalProcesspositive regulation of sodium:proton antiporter activity

DRD4 TESC

3.52e-0461012GO:0032417
GeneOntologyBiologicalProcessadenylate cyclase-inhibiting dopamine receptor signaling pathway

DRD4 ADCY5

3.52e-0461012GO:0007195
GeneOntologyBiologicalProcesspolysaccharide metabolic process

NPC1 GFPT1 PPP1CA PPP1CB PPP1CC

3.90e-041261015GO:0005976
GeneOntologyBiologicalProcesspositive regulation of transmembrane transport

DRD4 WNK1 TESC OGA WNK4 WNK3 WNK2

3.93e-042731017GO:0034764
GeneOntologyBiologicalProcessrhythmic process

DRD4 GFPT1 PPP1CA PPP1CB PPP1CC KMT2A GNA11 PRKDC

3.93e-043601018GO:0048511
GeneOntologyBiologicalProcessaction potential

HCN1 KCNB2 SCN1A SCN4A SCN8A GNA11

4.67e-042011016GO:0001508
GeneOntologyBiologicalProcessregulation of sodium:proton antiporter activity

DRD4 TESC

4.91e-0471012GO:0032415
GeneOntologyBiologicalProcesslocomotory behavior

NPC1 CACNA1A DRD4 GRM5 ADCY5 SCN1A SCN8A

4.98e-042841017GO:0007626
GeneOntologyBiologicalProcesslocalization within membrane

NPC1 CACNA1A STXBP5L GBP1 KCNB2 WNK1 DENND4C CD81 TESC OGA WNK4 WNK3

5.25e-0479810112GO:0051668
GeneOntologyBiologicalProcessprotein localization to membrane

NPC1 CACNA1A GBP1 KCNB2 WNK1 DENND4C CD81 TESC OGA WNK4 WNK3

6.70e-0470510111GO:0072657
GeneOntologyBiologicalProcessmembrane depolarization during action potential

SCN1A SCN4A SCN8A

7.24e-04361013GO:0086010
GeneOntologyBiologicalProcessimport into cell

NPC1 CACNA1A DRD4 SH3BP1 WNK1 SLC9A2 SLC15A1 KCNJ4 SLC22A1 KCNJ9 CD81 WNK4 WNK3 WNK2

7.36e-04107410114GO:0098657
GeneOntologyBiologicalProcessmonoatomic ion homeostasis

CACNA1A DRD4 SLC24A3 GRM5 WNK1 SLC9A2 ATP6V1D TESC WNK4 WNK3 WNK2

7.70e-0471710111GO:0050801
GeneOntologyBiologicalProcessregulation of glycogen biosynthetic process

GFPT1 PPP1CA PPP1CB

8.49e-04381013GO:0005979
GeneOntologyBiologicalProcessregulation of glucan biosynthetic process

GFPT1 PPP1CA PPP1CB

8.49e-04381013GO:0010962
GeneOntologyBiologicalProcessregulation of insulin secretion

STXBP5L ADCY5 SLC2A2 ABCG1 GNA11 OGA

9.67e-042311016GO:0050796
GeneOntologyBiologicalProcesscellular homeostasis

CACNA1A DRD4 SLC24A3 GRM5 WNK1 ADCY5 SLC2A2 ABCG1 SLC9A2 ATP6V1D TESC WNK4 WNK3

9.92e-0498110113GO:0019725
GeneOntologyBiologicalProcesscytosolic ribosome assembly

EFL1 PRKDC

1.04e-03101012GO:0042256
GeneOntologyBiologicalProcessformation of translation preinitiation complex

EIF2S3B EIF2S3

1.04e-03101012GO:0001731
GeneOntologyBiologicalProcessproximal tubule development

ACAT1 SLC22A1

1.04e-03101012GO:0072014
GeneOntologyBiologicalProcessintracellular chemical homeostasis

CACNA1A DRD4 SLC24A3 GRM5 WNK1 ADCY5 SLC2A2 ABCG1 SLC9A2 ATP6V1D TESC WNK4

1.07e-0386610112GO:0055082
GeneOntologyBiologicalProcessamide transport

STXBP5L ADCY5 SLC2A2 ABCG1 SLC14A1 SLC15A1 GNA11 OGA

1.07e-034201018GO:0042886
GeneOntologyBiologicalProcessprotein localization to cell periphery

GBP1 KCNB2 WNK1 DENND4C CD81 TESC WNK4 WNK3

1.11e-034221018GO:1990778
GeneOntologyBiologicalProcesscellular response to lipoprotein particle stimulus

NPC1 ABCG1 CD81

1.22e-03431013GO:0071402
GeneOntologyBiologicalProcessG protein-coupled dopamine receptor signaling pathway

DRD4 ADCY5 GNA11

1.30e-03441013GO:0007212
GeneOntologyBiologicalProcesspositive regulation of ion transmembrane transporter activity

DRD4 TESC WNK3 WNK2

1.32e-03971014GO:0032414
GeneOntologyBiologicalProcessregulation of potassium ion transmembrane transport

WNK1 WNK4 WNK3 WNK2

1.32e-03971014GO:1901379
GeneOntologyBiologicalProcesssignal release

CACNA1A DRD4 STXBP5L RIMS3 ADCY5 SLC2A2 ABCG1 GNA11 OGA WNK4

1.36e-0365310110GO:0023061
GeneOntologyBiologicalProcessglycogen metabolic process

GFPT1 PPP1CA PPP1CB PPP1CC

1.43e-03991014GO:0005977
GeneOntologyBiologicalProcessproton transmembrane transport

DRD4 SLC9A2 SLC15A1 ATP6V1D TESC

1.50e-031701015GO:1902600
GeneOntologyBiologicalProcessacetylcholine transport

CACNA1A SLC22A1

1.52e-03121012GO:0015870
GeneOntologyBiologicalProcessnegative regulation of monoatomic ion transport

DRD4 WNK1 WNK4 WNK3 WNK2

1.54e-031711015GO:0043271
GeneOntologyCellularComponentPTW/PP1 phosphatase complex

PPP1CA PPP1CB PPP1CC

3.89e-0671023GO:0072357
GeneOntologyCellularComponentcation channel complex

CACNA1A HCN1 PKD1L1 KCNB2 KCNJ4 SCN1A SCN4A SCN8A

2.00e-052351028GO:0034703
GeneOntologyCellularComponentvoltage-gated sodium channel complex

SCN1A SCN4A SCN8A

7.30e-05171023GO:0001518
GeneOntologyCellularComponentmonoatomic ion channel complex

CACNA1A HCN1 PKD1L1 KCNB2 KCNJ4 SCN1A KCNJ9 SCN4A SCN8A

9.80e-053781029GO:0034702
GeneOntologyCellularComponentprotein phosphatase type 1 complex

PPP1CA PPP1CB PPP1CC

1.03e-04191023GO:0000164
GeneOntologyCellularComponentbasolateral plasma membrane

HCN1 CLDN8 SLC2A2 SLC10A1 SLC14A1 KCNJ4 SLC22A1 CD81

1.74e-043201028GO:0016323
GeneOntologyCellularComponenttransmembrane transporter complex

CACNA1A HCN1 PKD1L1 KCNB2 KCNJ4 SCN1A KCNJ9 ATP6V1D SCN4A SCN8A

2.40e-0452310210GO:1902495
GeneOntologyCellularComponentbasal plasma membrane

HCN1 CLDN8 SLC2A2 SLC10A1 SLC14A1 KCNJ4 SLC22A1 CD81

3.44e-043541028GO:0009925
GeneOntologyCellularComponenteukaryotic translation initiation factor 2 complex

EIF2S3B EIF2S3

3.49e-0461022GO:0005850
GeneOntologyCellularComponenttransporter complex

CACNA1A HCN1 PKD1L1 KCNB2 KCNJ4 SCN1A KCNJ9 ATP6V1D SCN4A SCN8A

3.57e-0455010210GO:1990351
GeneOntologyCellularComponentsodium channel complex

SCN1A SCN4A SCN8A

3.76e-04291023GO:0034706
GeneOntologyCellularComponentpresynaptic membrane

CACNA1A DRD4 HCN1 RIMS3 SCN1A KCNJ9 SCN8A

4.20e-042771027GO:0042734
GeneOntologyCellularComponentbasal part of cell

HCN1 CLDN8 SLC2A2 SLC10A1 SLC14A1 KCNJ4 SLC22A1 CD81

5.31e-043781028GO:0045178
GeneOntologyCellularComponentsynaptic membrane

CACNA1A DRD4 HCN1 RIMS3 GRM5 KCNJ4 SCN1A KCNJ9 SCN8A TMEM240

5.63e-0458310210GO:0097060
GeneOntologyCellularComponentglycogen granule

PPP1CA PPP1CB

6.48e-0481022GO:0042587
GeneOntologyCellularComponentanchoring junction

FLNC GFRAL SH3BP1 CLDN8 SLC2A2 PPP1CA PPP1CB PPP1CC FAT1 SCN1A CD81 WNK4 WNK3

9.20e-0497610213GO:0070161
GeneOntologyCellularComponentparallel fiber to Purkinje cell synapse

KCNJ9 SCN8A TMEM240

1.21e-03431023GO:0098688
GeneOntologyCellularComponentphosphatase complex

PPP1CA PPP1CB PPP1CC

2.46e-03551023GO:1903293
GeneOntologyCellularComponentprotein serine/threonine phosphatase complex

PPP1CA PPP1CB PPP1CC

2.46e-03551023GO:0008287
DomainKinase_OSR1/WNK_CCT

WNK1 WNK4 WNK3 WNK2

9.75e-096964IPR024678
DomainOSR1_C

WNK1 WNK4 WNK3 WNK2

9.75e-096964PF12202
DomainSTPPase_N

PPP1CA PPP1CB PPP1CC

1.32e-073963IPR031675
DomainSTPPase_N

PPP1CA PPP1CB PPP1CC

1.32e-073963PF16891
DomainNa_channel_asu

SCN1A SCN4A SCN8A

1.54e-0510963IPR001696
DomainNa_trans_assoc

SCN1A SCN4A SCN8A

1.54e-0510963IPR010526
DomainNa_trans_assoc

SCN1A SCN4A SCN8A

1.54e-0510963PF06512
DomainIon_trans_dom

CACNA1A HCN1 KCNB2 SCN1A SCN4A SCN8A

2.69e-05114966IPR005821
DomainIon_trans

CACNA1A HCN1 KCNB2 SCN1A SCN4A SCN8A

2.69e-05114966PF00520
DomainSer/Thr-sp_prot-phosphatase

PPP1CA PPP1CB PPP1CC

3.63e-0513963IPR006186
DomainSER_THR_PHOSPHATASE

PPP1CA PPP1CB PPP1CC

3.63e-0513963PS00125
DomainPP2Ac

PPP1CA PPP1CB PPP1CC

3.63e-0513963SM00156
DomainRCC1

RCC2 HERC2 HERC1

1.41e-0420963PF00415
DomainBilac:Na_transpt

SLC10A1 SLC10A6

1.56e-044962IPR004710
DomainRCC1_1

RCC2 HERC2 HERC1

1.64e-0421963PS00625
DomainRCC1_2

RCC2 HERC2 HERC1

1.64e-0421963PS00626
DomainRCC1_3

RCC2 HERC2 HERC1

1.64e-0421963PS50012
DomainReg_chr_condens

RCC2 HERC2 HERC1

1.89e-0422963IPR000408
Domain-

RCC2 HERC2 HERC1

1.89e-04229632.130.10.30
DomainIg_E-set

FLNC PKHD1L1 TGM4 KCNJ4 KCNJ9

1.99e-04104965IPR014756
DomainChannel_four-helix_dom

CACNA1A SCN1A SCN4A SCN8A

2.10e-0457964IPR027359
Domain-

CACNA1A SCN1A SCN4A SCN8A

2.10e-04579641.20.120.350
DomainRCC1/BLIP-II

RCC2 HERC2 HERC1

2.16e-0423963IPR009091
DomainThiolase_AS

ACAT1 HADHB

2.59e-045962IPR020610
DomainThiolase_acyl_enz_int_AS

ACAT1 HADHB

2.59e-045962IPR020615
DomainThiolase_C

ACAT1 HADHB

3.87e-046962PF02803
DomainNa_trans_cytopl

SCN1A SCN8A

3.87e-046962PF11933
DomainThiolase_N

ACAT1 HADHB

3.87e-046962PF00108
DomainTHIOLASE_2

ACAT1 HADHB

3.87e-046962PS00737
DomainTHIOLASE_1

ACAT1 HADHB

3.87e-046962PS00098
DomainTHIOLASE_3

ACAT1 HADHB

3.87e-046962PS00099
DomainThiolase_N

ACAT1 HADHB

3.87e-046962IPR020616
DomainThiolase_C

ACAT1 HADHB

3.87e-046962IPR020617
DomainThiolase_CS

ACAT1 HADHB

3.87e-046962IPR020613
DomainThiolase

ACAT1 HADHB

3.87e-046962IPR002155
DomainNa_trans_cytopl

SCN1A SCN8A

3.87e-046962IPR024583
DomainHaem_d1

STXBP5L KMT2A

3.87e-046962IPR011048
DomainCalcineurin-like_PHP_ApaH

PPP1CA PPP1CB PPP1CC

3.93e-0428963IPR004843
DomainMetallophos

PPP1CA PPP1CB PPP1CC

3.93e-0428963PF00149
DomainMetallo-depent_PP-like

PPP1CA PPP1CB PPP1CC

4.83e-0430963IPR029052
Domain-

PPP1CA PPP1CB PPP1CC

4.83e-04309633.60.21.10
DomainBilAc:Na_symport/Acr3

SLC10A1 SLC10A6

5.40e-047962IPR002657
DomainSBF

SLC10A1 SLC10A6

5.40e-047962PF01758
DomainGAF

PDE6A PDE11A

5.40e-047962PF01590
DomainGAF

PDE6A PDE11A

7.17e-048962IPR003018
DomainGAF

PDE6A PDE11A

7.17e-048962SM00065
DomainGAF_dom-like

PDE6A PDE11A

9.19e-049962IPR029016
Domain-

PDE6A PDE11A

9.19e-0499623.30.450.40
DomainOlfact_rcpt

OR13C8 OR13C3 OR13F1 OR2S2 OR2T6 OR13C9 OR13C2 OR6Y1

9.47e-04393968IPR000725
Domain-

ACAT1 HADHB

1.15e-03109623.40.47.10
DomainThiolase-like

ACAT1 HADHB

1.15e-0310962IPR016039
DomainK_chnl_inward-rec_Kir_cyto

KCNJ4 KCNJ9

2.99e-0316962IPR013518
DomainIRK

KCNJ4 KCNJ9

2.99e-0316962PF01007
Domain-

KCNJ4 KCNJ9

2.99e-03169622.60.40.1400
DomainK_chnl_inward-rec_Kir

KCNJ4 KCNJ9

2.99e-0316962IPR016449
DomainEFTu-like_2

EFL1 EIF2S3

3.79e-0318962IPR004161
DomainGTP_EFTU_D2

EFL1 EIF2S3

3.79e-0318962PF03144
DomainG_TR_2

EFL1 EIF2S3

3.79e-0318962PS51722
DomainTF_GTP-bd_dom

EFL1 EIF2S3

4.22e-0319962IPR000795
DomainPDEase

PDE6A PDE11A

4.22e-0319962IPR023088
DomainMFS_dom

SLC2A2 SLC15A1 SLC22A1 MFSD5

5.06e-03134964IPR020846
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

NPC1 ANO9 SLC24A3 WNK1 ADCY5 SLC2A2 ABCG1 SLC9A2 SLC14A1 SLC15A1 EIF2S3 SLC22A1 ATP6V1D SLC10A6 WNK4 WNK3 WNK2

8.80e-077368217M27287
PathwayWP_COMMON_PATHWAYS_UNDERLYING_DRUG_ADDICTION

DRD4 GRM5 PPP1CA PPP1CB PPP1CC

3.74e-0641825M39655
PathwayKEGG_MEDICUS_REFERENCE_REGULATION_OF_GF_RTK_RAS_ERK_SIGNALING_MRAS_SHOC2_PP1_HOLOPHOSPHATASE

PPP1CA PPP1CB PPP1CC

1.04e-058823M47933
PathwayWP_CIRCADIAN_RHYTHM_GENES

DRD4 GFPT1 PPP1CA PPP1CB PPP1CC KMT2A GNA11 PRKDC

2.15e-05201828M39605
PathwayKEGG_MEDICUS_REFERENCE_CENPE_INTERACTION_WITH_NDC80_COMPLEX

PPP1CA PPP1CB PPP1CC

4.02e-0512823M47887
PathwayKEGG_MEDICUS_REFERENCE_DEPHOSPHORYLATION_OF_KINETOCHORE

PPP1CA PPP1CB PPP1CC

4.02e-0512823M47891
PathwayREACTOME_RESPIRATORY_SYNCYTIAL_VIRUS_RSV_GENOME_REPLICATION_TRANSCRIPTION_AND_TRANSLATION

PPP1CA PPP1CB PPP1CC

1.01e-0416823M48235
PathwayREACTOME_TRANSPORT_OF_SMALL_MOLECULES

NPC1 ANO9 SLC24A3 EIF2S3B SLC2A2 ABCG1 SLC9A2 SLC14A1 SLC15A1 EIF2S3 SLC22A1 ATP6V1D SLC10A6

1.43e-046818213MM14985
PathwayREACTOME_TRIGLYCERIDE_CATABOLISM

PPP1CA PPP1CB PPP1CC

3.52e-0424823M10064
PathwayREACTOME_STIMULI_SENSING_CHANNELS

ANO9 WNK1 WNK4 WNK3 WNK2

3.77e-04106825M27200
PathwayKEGG_OLFACTORY_TRANSDUCTION

OR13C8 OR13C3 OR13F1 OR4C45 OR2S2 OR2T6 OR13C9 OR13C2 OR6Y1

4.19e-04389829M14091
PathwayREACTOME_REGULATION_OF_INSULIN_SECRETION

CACNA1A ADCY5 SLC2A2 GNA11

4.31e-0461824MM15071
PathwayREACTOME_DOWNREGULATION_OF_TGF_BETA_RECEPTOR_SIGNALING

PPP1CA PPP1CB PPP1CC

4.48e-0426823M628
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC24A3 SLC2A2 SLC9A2 SLC14A1 SLC15A1 SLC22A1 SLC10A6

4.64e-04238827MM15076
PathwayKEGG_OOCYTE_MEIOSIS

ADCY5 PPP1CA PPP1CB PPP1CC CCNE1

5.06e-04113825M16817
PathwayKEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION

ADCY5 PPP1CA PPP1CB PPP1CC GNA11

5.48e-04115825M9387
PathwayWP_DRAVET_SYNDROME

HCN1 SCN1A SCN8A

5.60e-0428823M45519
PathwayREACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT

SLC24A3 SLC2A2 SLC9A2 SLC14A1 SLC15A1 SLC22A1 SLC10A6

6.08e-04249827M5988
PathwayREACTOME_ION_CHANNEL_TRANSPORT

ANO9 WNK1 ATP6V1D WNK4 WNK3 WNK2

6.82e-04183826M997
PathwayWP_DISTAL_CONVOLUTED_TUBULE_1_DCT1_CELL

WNK1 WNK4

6.89e-047822MM15929
PathwayREACTOME_OLFACTORY_SIGNALING_PATHWAY

OR13C8 OR13C3 OR13F1 OR4C45 OR2S2 OR2T6 OR13C9 OR13C2 OR6Y1

6.91e-04417829M4072
PathwayREACTOME_NEURONAL_SYSTEM

CACNA1A HCN1 KCNB2 GRM5 ADCY5 KCNJ4 SLC22A1 KCNJ9

7.23e-04335828MM14503
PathwayKEGG_LONG_TERM_POTENTIATION

GRM5 PPP1CA PPP1CB PPP1CC

7.28e-0470824M3115
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SCN1A SCN4A SCN8A

7.58e-0431823M877
PathwayREACTOME_INTEGRATION_OF_ENERGY_METABOLISM

CACNA1A ADCY5 SLC2A2 GNA11

8.10e-0472824MM14631
PathwayREACTOME_PHASE_0_RAPID_DEPOLARISATION

SCN1A SCN4A SCN8A

8.33e-0432823M27455
PathwayREACTOME_SIGNALING_BY_MRAS_COMPLEX_MUTANTS

PPP1CB PPP1CC

9.15e-048822M38999
PathwayREACTOME_REGULATION_OF_INSULIN_SECRETION

CACNA1A ADCY5 SLC2A2 GNA11

1.09e-0378824M1921
PathwayREACTOME_RECYCLING_OF_EIF2_GDP

EIF2S3B EIF2S3

1.17e-039822MM15418
PathwayREACTOME_TRIGLYCERIDE_METABOLISM

PPP1CA PPP1CB PPP1CC

1.38e-0338823M27856
PathwayREACTOME_CELLULAR_RESPONSE_TO_MITOCHONDRIAL_STRESS

EIF2S3B EIF2S3

1.46e-0310822MM17234
PathwayBIOCARTA_EIF_PATHWAY

EIF2S3B EIF2S3

1.46e-0310822MM1394
PathwayBIOCARTA_EIF2_PATHWAY

EIF2S3B EIF2S3

1.46e-0310822MM1469
PathwayKEGG_MEDICUS_REFERENCE_BETA_OXIDATION

ACAT1 HADHB

1.78e-0311822M47630
Pubmed

Organization and evolutionary relatedness of OR37 olfactory receptor genes in mouse and human.

OR13C8 OR13C3 OR2S2 OR13C6P OR13C9 OR13C2 OR13C7

1.18e-1512102712906860
Pubmed

WNK kinases, a novel protein kinase subfamily in multi-cellular organisms.

WNK1 WNK4 WNK3 WNK2

6.97e-114102411571656
Pubmed

Human hypertension caused by mutations in WNK kinases.

WNK1 WNK4 WNK3 WNK2

6.97e-114102411498583
Pubmed

Axon morphogenesis and maintenance require an evolutionary conserved safeguard function of Wnk kinases antagonizing Sarm and Axed.

WNK1 WNK4 WNK3 WNK2

6.97e-114102434384519
Pubmed

Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members.

WNK1 WNK4 WNK3 WNK2

2.42e-097102420525693
Pubmed

The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction.

WNK1 WNK4 WNK3 WNK2

4.84e-098102423387299
Pubmed

KLHL2 interacts with and ubiquitinates WNK kinases.

WNK1 WNK4 WNK3 WNK2

4.84e-098102423838290
Pubmed

Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development.

CACNA1A HCN1 KCNB2 KCNJ4 SCN1A KCNJ9 SCN4A SCN8A

8.49e-09139102816985003
Pubmed

1E7-03, a low MW compound targeting host protein phosphatase-1, inhibits HIV-1 transcription.

PPP1CA PPP1CB PPP1CC

2.45e-083102325073485
Pubmed

Chromosomal localization of human, rat, and mouse protein phosphatase type 1 beta catalytic subunit genes (PPP1CB) by fluorescence in situ hybridization.

PPP1CA PPP1CB PPP1CC

2.45e-08310237857673
Pubmed

Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock.

PPP1CA PPP1CB PPP1CC

2.45e-083102321712997
Pubmed

Nuclear targeting of protein phosphatase-1 by HIV-1 Tat protein.

PPP1CA PPP1CB PPP1CC

9.78e-084102316131488
Pubmed

Nuclear protein phosphatase-1 regulates HIV-1 transcription.

PPP1CA PPP1CB PPP1CC

9.78e-084102312788939
Pubmed

Protein phosphatase 1 inhibits p53 signaling by dephosphorylating and stabilizing Mdmx.

PPP1CA PPP1CB PPP1CC

9.78e-084102323277204
Pubmed

SLC26A9 is a Cl(-) channel regulated by the WNK kinases.

WNK1 WNK4 WNK3

9.78e-084102317673510
Pubmed

Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1.

PPP1CA PPP1CB PPP1CC

9.78e-084102310194355
Pubmed

Small molecules targeted to a non-catalytic "RVxF" binding site of protein phosphatase-1 inhibit HIV-1.

PPP1CA PPP1CB PPP1CC

9.78e-084102322768081
Pubmed

Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1.

PPP1CA PPP1CB PPP1CC

9.78e-084102312226088
Pubmed

N-CoR controls differentiation of neural stem cells into astrocytes.

PPP1CA PPP1CB PPP1CC

9.78e-084102312410313
Pubmed

Distinct roles for the α , β and γ1 isoforms of protein phosphatase 1 in the outside-in αIIbβ3 integrin signalling-dependent functions.

PPP1CA PPP1CB PPP1CC

2.44e-075102323197154
Pubmed

Structural and biochemical characterization of the KLHL3-WNK kinase interaction important in blood pressure regulation.

WNK1 WNK4 WNK3

2.44e-075102324641320
Pubmed

Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220.

PPP1CA PPP1CB PPP1CC

2.44e-075102310209101
Pubmed

The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity.

PPP1CA PPP1CB PPP1CC

2.44e-075102312016208
Pubmed

Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle.

PPP1CA PPP1CB PPP1CC

2.44e-075102311551964
Pubmed

The heterotrimeric G protein Gβ1 interacts with the catalytic subunit of protein phosphatase 1 and modulates G protein-coupled receptor signaling in platelets.

PPP1CA PPP1CB PPP1CC

2.44e-075102328615442
Pubmed

A PP1-PP2A phosphatase relay controls mitotic progression.

PPP1CA PPP1CB PPP1CC

2.44e-075102325487150
Pubmed

SUMOylation of the transcriptional co-repressor KAP1 is regulated by the serine and threonine phosphatase PP1.

PPP1CA PPP1CB PPP1CC

2.44e-075102320424263
Pubmed

The interaction of PP1 with BRCA1 and analysis of their expression in breast tumors.

PPP1CA PPP1CB PPP1CC

2.44e-075102317511879
Pubmed

SIPP1, a novel pre-mRNA splicing factor and interactor of protein phosphatase-1.

PPP1CA PPP1CB PPP1CC

4.87e-076102314640981
Pubmed

Dissociation of SHP-1 from spinophilin during platelet activation exposes an inhibitory binding site for protein phosphatase-1 (PP1).

PPP1CA PPP1CB PPP1CC

4.87e-076102325785436
Pubmed

Inhibitory member of the apoptosis-stimulating proteins of the p53 family (iASPP) interacts with protein phosphatase 1 via a noncanonical binding motif.

PPP1CA PPP1CB PPP1CC

4.87e-076102321998301
Pubmed

WNK2 kinase is a novel regulator of essential neuronal cation-chloride cotransporters.

WNK1 WNK4 WNK2

4.87e-076102321733846
Pubmed

Protein phosphatase 1 regulates the phosphorylation state of the polarity scaffold Par-3.

PPP1CA PPP1CB PPP1CC

4.87e-076102318641122
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

FLNC ACAT1 RCC2 GFPT1 DHX8 PPP1CA PPP1CB PPP1CC KMT2A UTP20 PRKDC HERC2

5.04e-076531021222586326
Pubmed

Different evolutionary processes shaped the mouse and human olfactory receptor gene families.

OR13C8 OR13C3 OR13F1 OR4C45 OR52P1 OR2T6 OR6Y1 OR13C7 OR2W6P

7.57e-07340102911875048
Pubmed

The olfactory receptor gene superfamily of the mouse.

OR13C8 OR13C3 OR13F1 OR4C45 OR52P1 OR2T6 OR6Y1 OR13C7 OR2W6P

7.57e-07340102911802173
Pubmed

A unified nomenclature for vertebrate olfactory receptors.

OR13C8 OR13C3 OR13F1 OR4C45 OR52P1 OR2T6 OR6Y1 OR13C7 OR2W6P

8.14e-07343102932295537
Pubmed

A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3beta (GSK-3beta ) and mediates protein kinase A-dependent inhibition of GSK-3beta.

PPP1CA PPP1CB PPP1CC

8.50e-077102312147701
Pubmed

Inhibitor-2 prevents protein phosphatase 1-induced cardiac hypertrophy and mortality.

PPP1CA PPP1CB PPP1CC

8.50e-077102318689497
Pubmed

SARP, a new alternatively spliced protein phosphatase 1 and DNA interacting protein.

PPP1CA PPP1CB PPP1CC

8.50e-077102317123353
Pubmed

Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.

OR13C8 OR13C3 OR13F1 OR4C45 OR52P1 OR2T6 OR6Y1 OR13C7 OR2W6P

8.75e-07346102914611657
Pubmed

Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation.

PPP1CA PPP1CB PPP1CC

1.36e-068102316262633
Pubmed

The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1.

PPP1CA PPP1CB PPP1CC

1.36e-068102321930935
Pubmed

A protein phosphatase from human T cells augments tat transactivation of the human immunodeficiency virus type 1 long-terminal repeat.

PPP1CA PPP1CB PPP1CC

1.36e-068102312036313
Pubmed

IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway.

WNK1 WNK4 WNK3

1.36e-068102321317537
Pubmed

International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels.

SCN1A SCN4A SCN8A

2.03e-069102316382098
Pubmed

G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase.

DRD4 ADCY5 KCNJ9

2.03e-069102312297500
Pubmed

RRP1B targets PP1 to mammalian cell nucleoli and is associated with Pre-60S ribosomal subunits.

PPP1CA PPP1CB PPP1CC

2.03e-069102320926688
Pubmed

Consensus PP1 binding motifs regulate transcriptional corepression and alternative RNA splicing activities of the steroid receptor coregulators, p54nrb and PSF.

PPP1CA PPP1CB PPP1CC

2.03e-069102321566083
Pubmed

Expression pattern of neuronal and skeletal muscle voltage-gated Na+ channels in the developing mouse heart.

SCN1A SCN4A SCN8A

2.03e-069102315746173
Pubmed

The European renal genome project: an integrated approach towards understanding the genetics of kidney development and disease.

CLDN8 GFPT1 SLC2A2 ST6GAL2 SLC9A2 SLC22A1 SLC10A6

3.20e-06212102719521566
Pubmed

L-type voltage-dependent calcium channel alpha subunit 1C is a novel candidate gene associated with secondary hyperparathyroidism: an application of haplotype-based analysis for multiple linked single nucleotide polymorphisms.

SLC2A2 SLC10A1 SLC14A1 SLC15A1 KCNJ4 SLC22A1

4.23e-06143102620424473
Pubmed

PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts.

PPP1CA PPP1CB PPP1CC

5.29e-0612102310830164
Pubmed

Reduction of Kcnt1 is therapeutic in mouse models of SCN1A and SCN8A epilepsy.

SCN1A SCN8A

8.52e-062102237901435
Pubmed

An Scn1a epilepsy mutation in Scn8a alters seizure susceptibility and behavior.

SCN1A SCN8A

8.52e-062102226410685
Pubmed

The fission yeast dis2+ gene required for chromosome disjoining encodes one of two putative type 1 protein phosphatases.

PPP1CB PPP1CC

8.52e-06210222544298
Pubmed

Hypertension associated polymorphisms in WNK1/WNK4 are not associated with hydrochlorothiazide response.

WNK1 WNK4

8.52e-062102221704025
Pubmed

WNKs are potassium-sensitive kinases.

WNK4 WNK3

8.52e-062102233439774
Pubmed

Effect of heterozygous deletion of WNK1 on the WNK-OSR1/ SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels.

WNK1 WNK4

8.52e-062102222294159
Pubmed

Scn8a Antisense Oligonucleotide Is Protective in Mouse Models of SCN8A Encephalopathy and Dravet Syndrome.

SCN1A SCN8A

8.52e-062102231943325
Pubmed

Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo.

WNK1 WNK4

8.52e-062102216899520
Pubmed

Regulation of Na+-K+-Cl- cotransporter type 2 by the with no lysine kinase-dependent signaling pathway.

WNK1 WNK3

8.52e-062102230917032
Pubmed

WNK-SPAK-NCC cascade revisited: WNK1 stimulates the activity of the Na-Cl cotransporter via SPAK, an effect antagonized by WNK4.

WNK1 WNK4

8.52e-062102225113964
Pubmed

Protein phosphatase 1 abrogates IRF7-mediated type I IFN response in antiviral immunity.

PPP1CA PPP1CB

8.52e-062102227469204
Pubmed

Kidney-specific WNK1 isoform (KS-WNK1) is a potent activator of WNK4 and NCC.

WNK1 WNK4

8.52e-062102229846116
Pubmed

The expression of the solute carriers NTCP and OCT-1 is regulated by cholesterol in HepG2 cells.

SLC10A1 SLC22A1

8.52e-062102217635184
Pubmed

Spermiogenesis is impaired in mice bearing a targeted mutation in the protein phosphatase 1cgamma gene.

PPP1CA PPP1CC

8.52e-06210229882500
Pubmed

Impact of the Uridine⁻Cytidine Kinase Like-1 Protein and IL28B rs12979860 and rs8099917 SNPs on the Development of Hepatocellular Carcinoma in Cirrhotic Chronic Hepatitis C Patients-A Pilot Study.

UCKL1 IFNL3

8.52e-062102230344298
Pubmed

WNK Inhibition Increases Surface Liquid pH and Host Defense in Cystic Fibrosis Airway Epithelia.

WNK1 WNK2

8.52e-062102235849656
Pubmed

WNK kinases regulate thiazide-sensitive Na-Cl cotransport.

WNK1 WNK4

8.52e-062102212671053
Pubmed

Protein phosphatase 1-dependent transcriptional programs for long-term memory and plasticity.

PPP1CB PPP1CC

8.52e-062102220592054
Pubmed

PP-1α and PP-1γ display antagonism and differential roles in tumorigenicity of lung cancer cells.

PPP1CA PPP1CC

8.52e-062102223176181
Pubmed

Aberrant regulation of a poison exon caused by a non-coding variant in a mouse model of Scn1a-associated epileptic encephalopathy.

SCN1A SCN8A

8.52e-062102233411788
Pubmed

WNK3 and WNK4 amino-terminal domain defines their effect on the renal Na+-Cl- cotransporter.

WNK4 WNK3

8.52e-062102218701621
Pubmed

Inherited neuronal ion channelopathies: new windows on complex neurological diseases.

CACNA1A SCN1A

8.52e-062102219005038
Pubmed

WNK kinases regulate sodium chloride and potassium transport by the aldosterone-sensitive distal nephron.

WNK1 WNK4

8.52e-062102216820787
Pubmed

Persistent Nav1.1 and Nav1.6 currents drive spinal locomotor functions through nonlinear dynamics.

SCN1A SCN8A

8.52e-062102237665666
Pubmed

The voltage-gated sodium channel Scn8a is a genetic modifier of severe myoclonic epilepsy of infancy.

SCN1A SCN8A

8.52e-062102217881658
Pubmed

Sexually dimorphic expression of the X-linked gene Eif2s3x mRNA but not protein in mouse brain.

EIF2S3B EIF2S3

8.52e-062102216325480
Pubmed

Dephosphorylation of CDK9 by protein phosphatase 2A and protein phosphatase-1 in Tat-activated HIV-1 transcription.

PPP1CA PPP1CB PPP1CC

8.71e-0614102316048649
Pubmed

A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis.

PPP1CA PPP1CB PPP1CC CCNE1

1.23e-0548102417274640
Pubmed

Regulation of HIV-1 transcription by protein phosphatase 1.

PPP1CA PPP1CB PPP1CC

1.62e-0517102317266553
Pubmed

[Action of protein phosphatase-1 on Tat-dependent HIV-1 transcription and its related inhibitors].

PPP1CA PPP1CB PPP1CC

1.62e-0517102321351466
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

NPC1 FLNC ZNF395 WNK1 CCNE1 FAT1 UCKL1 SCN8A PRKDC HERC2 HERC1 MFSD5 WNK2

2.14e-0511051021335748872
Pubmed

Systematic analysis of three FHM genes in 39 sporadic patients with hemiplegic migraine.

CACNA1A SCN1A

2.55e-053102218056581
Pubmed

Mutually exclusive binding of PP1 and RNA to AKAP149 affects the mitochondrial network.

PPP1CA PPP1CC

2.55e-053102219074462
Pubmed

The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex.

WNK4 WNK3

2.55e-053102217975670
Pubmed

PAI1: a novel PP1-interacting protein that mediates human plasma's anti-apoptotic effect in endothelial cells.

PPP1CA PPP1CB

2.55e-053102228296156
Pubmed

Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia.

KMT2A PRKDC

2.55e-053102218538732
Pubmed

The direct binding of the catalytic subunit of protein phosphatase 1 to the PKR protein kinase is necessary but not sufficient for inactivation and disruption of enzyme dimer formation.

PPP1CA PPP1CC

2.55e-053102212138106
Pubmed

Familial Hemiplegic Migraine

CACNA1A SCN1A

2.55e-053102220301562
Pubmed

Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice.

WNK1 WNK4

2.55e-053102224821705
Pubmed

Three Novel Genetic Variants in the FAM110D, CACNA1A, and NLRP12 Genes Are Associated With Susceptibility to Hypertension Among Dai People.

CACNA1A NLRP1

2.55e-053102233621312
Pubmed

Role of WNK4 and kidney-specific WNK1 in mediating the effect of high dietary K+ intake on ROMK channel in the distal convoluted tubule.

WNK1 WNK4

2.55e-053102229667910
Pubmed

Wnk kinases are positive regulators of canonical Wnt/β-catenin signalling.

WNK1 WNK2

2.55e-053102223797875
Pubmed

Dynamic targeting of protein phosphatase 1 within the nuclei of living mammalian cells.

PPP1CA PPP1CC

2.55e-053102211739654
Pubmed

The contribution of CACNA1A, ATP1A2 and SCN1A mutations in hemiplegic migraine: A clinical and genetic study in Finnish migraine families.

CACNA1A SCN1A

2.55e-053102229486580
Pubmed

Regulation of the expression of the Na/Cl cotransporter by WNK4 and WNK1: evidence that accelerated dynamin-dependent endocytosis is not involved.

WNK1 WNK4

2.55e-053102216788137
Pubmed

WNK3 positively regulates epithelial calcium channels TRPV5 and TRPV6 via a kinase-dependent pathway.

WNK3 WNK2

2.55e-053102218768590
Pubmed

Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance.

KMT2A PRKDC

2.55e-053102232763164
InteractionPPP1R2C interactions

PPP1CA PPP1CB PPP1CC

3.79e-074933int:PPP1R2C
InteractionCSRNP2 interactions

PPP1CA PPP1CB PPP1CC

9.45e-075933int:CSRNP2
InteractionKLHL3 interactions

WNK1 CLDN8 WNK4 WNK3 WNK2

1.57e-0643935int:KLHL3
InteractionSFRP5 interactions

PPP1CA PPP1CB PPP1CC

1.88e-066933int:SFRP5
InteractionGNB2 interactions

CACNA1A SH3BP1 GBP1 RNF213 ACSF2 PPP1CC FAT1 GNA11 CD81 HADHB WNK2

1.99e-055029311int:GNB2
InteractionADCY2 interactions

DRD4 SPPL3 ADCY5

2.63e-0513933int:ADCY2
InteractionPPP1R2B interactions

PPP1CA PPP1CB PPP1CC

3.34e-0514933int:PPP1R2B
InteractionPPP1R15A interactions

PPP1CA PPP1CB PPP1CC KMT2A

3.42e-0540934int:PPP1R15A
InteractionSCN11A interactions

CACNA1A SCN1A SCN8A

4.16e-0515933int:SCN11A
InteractionPRR16 interactions

SPPL3 PPP1CA PPP1CC

5.10e-0516933int:PRR16
InteractionKLHL2 interactions

WNK1 UCKL1 WNK4 WNK3 WNK2

5.74e-0589935int:KLHL2
InteractionKCNJ3 interactions

DRD4 SPPL3 KCNJ9

7.38e-0518933int:KCNJ3
InteractionPPP1R3B interactions

PPP1CA PPP1CB PPP1CC

8.74e-0519933int:PPP1R3B
InteractionPLCL2 interactions

PPP1CA PPP1CB PPP1CC

8.74e-0519933int:PLCL2
InteractionGNB1 interactions

CACNA1A RNF213 PPP1CA PPP1CB PPP1CC GNA11 CD81 HADHB

8.78e-05307938int:GNB1
InteractionWBP11 interactions

SH3BP1 DHX8 PPP1CA PPP1CB PPP1CC TESC

9.83e-05160936int:WBP11
InteractionSCN8A interactions

SPPL3 SCN4A SCN8A

1.02e-0420933int:SCN8A
InteractionCLOCK interactions

PDE6A PPP1CA PPP1CB PPP1CC KMT2A

1.10e-04102935int:CLOCK
InteractionCSRNP1 interactions

PPP1CA PPP1CB PPP1CC

1.19e-0421933int:CSRNP1
InteractionLY6K interactions

NPC1 SPPL3

1.26e-044932int:LY6K
InteractionC9orf50 interactions

SPPL3 PPP1CC

1.26e-044932int:C9orf50
InteractionPPP1R12C interactions

CACNA1A PPP1CA PPP1CB PPP1CC

1.49e-0458934int:PPP1R12C
InteractionSIRT7 interactions

FLNC ACAT1 RCC2 GFPT1 DHX8 PPP1CA PPP1CB PPP1CC KMT2A UTP20 PRKDC HERC2

1.58e-047449312int:SIRT7
InteractionGSK3B interactions

HCN1 RCC2 GFPT1 DENND4C PPP1CA PPP1CB PPP1CC CCNE1 FNIP1 PRKDC HADHB HERC2 OGA

1.72e-048689313int:GSK3B
InteractionCACNA1D interactions

CACNA1A KCNB2 SCN1A

1.79e-0424933int:CACNA1D
InteractionDRD4 interactions

DRD4 KCNJ9 PRKDC

2.03e-0425933int:DRD4
InteractionSFRP1 interactions

PPP1CA PPP1CB PPP1CC

2.03e-0425933int:SFRP1
InteractionUBXN2A interactions

PPP1CA PPP1CB PPP1CC

2.29e-0426933int:UBXN2A
InteractionPPP1R16B interactions

PPP1CA PPP1CB PPP1CC KLHL13

2.32e-0465934int:PPP1R16B
Cytoband9q31.1

OR13C8 OR13C3 OR13F1 OR13C9 OR13C2

3.45e-084110259q31.1
CytobandEnsembl 112 genes in cytogenetic band chr9q31

OR13C8 OR13C3 OR13F1 OR13C9 OR13C2

1.45e-051371025chr9q31
Cytoband9p13.3

OR2S2 OR13C6P OR13C7

6.40e-047510239p13.3
Cytoband2p23

PPP1CB HADHB

6.50e-041710222p23
Cytoband11p15.5

ANO9 DRD4 CD81

2.36e-03118102311p15.5
Cytoband1q23.2

SLAMF9 KCNJ9

2.77e-033510221q23.2
GeneFamilyOlfactory receptors, family 13

OR13C8 OR13C3 OR13F1 OR13C6P OR13C9 OR13C2 OR13C7

3.35e-1223747162
GeneFamilySodium voltage-gated channel alpha subunits

SCN1A SCN4A SCN8A

5.43e-0697431203
GeneFamilyProtein phosphatase catalytic subunits|EF-hand domain containing

PPP1CA PPP1CB PPP1CC

1.83e-0513743693
GeneFamilySolute carriers

SLC24A3 SLC2A2 SLC9A2 SLC10A1 SLC14A1 SLC15A1 SLC22A1 SLC10A6

2.07e-04395748752
GeneFamilyPotassium voltage-gated channel subfamily J

KCNJ4 KCNJ9

1.91e-0316742276
GeneFamilyPhosphodiesterases

PDE6A PDE11A

4.30e-0324742681
GeneFamilyGuanylate cyclase receptors|DENN/MADD domain containing

DENND4C FNIP1

4.66e-0325742504
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_top-relative-expression-ranked_1000

NPC1 FLNC GBP1 RNF213 SLC24A3 ZNF395 DENND4C SERPINB6 FBN2 EIF2S3 KLHL13 WNK3

8.59e-057978612gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_Sma_1000
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_top-relative-expression-ranked_500

FLNC RNF213 SLC24A3 DENND4C SERPINB6 FBN2 KLHL13 WNK3

1.00e-04357868gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_500
CoexpressionAtlasdev gonad_e13.5_M_SertoliCell_Sox9_k-means-cluster#4_top-relative-expression-ranked_200

RNF213 SERPINB6 WNK3

1.22e-0424863gudmap_dev gonad_e13.5_M_SertoliCell_Sox9_k4_200
CoexpressionAtlasFacebaseRNAseq_e9.5_Mandibular Arch_top-relative-expression-ranked_500_k-means-cluster#1

RCC2 TMEM121 CCNE1 TRMT6 EIF2S3 UTP20

1.42e-04195866Facebase_RNAseq_e9.5_Mandibular Arch_500_K1
CoexpressionAtlasdev gonad_e12.5_M_SertoliCell_Sox9_k-means-cluster#2_top-relative-expression-ranked_200

RNF213 SERPINB6 WNK3

1.56e-0426863gudmap_dev gonad_e12.5_M_SertoliCell_Sox9_k2_200
CoexpressionAtlasFacebaseRNAseq_e8.5_Non-Floor Plate Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#5

CACNA1A STXBP5L SLC24A3 ACSF2 KMT2E BBS9 ST6GAL2 FAT1 RHBDL3 IGSF1 WNK2

1.76e-047328611Facebase_RNAseq_e8.5_Non-Floor Plate Neural Epithelium_2500_K5
CoexpressionAtlasdev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_top-relative-expression-ranked_1000

NPC1 FLNC RNF213 SLC24A3 ZNF395 WNK1 DENND4C SERPINB6 FBN2 KLHL13 WNK3

1.94e-047408611gudmap_dev gonad_e13.5_F_VascAssocMesenchStromOvary_MafB_1000
CoexpressionAtlasBM Top 100 - cerebral cortex

HCN1 RIMS3 KCNJ4 SCN1A

2.09e-0472864BM Top 100 - cerebral cortex
CoexpressionAtlasFacebaseRNAseq_e9.5_Maxillary Arch_top-relative-expression-ranked_2500_k-means-cluster#2

CACNA1A STXBP5L SLC24A3 ACSF2 KMT2E BBS9 ST6GAL2 FAT1 RHBDL3 IGSF1 WNK2

2.10e-047478611Facebase_RNAseq_e9.5_Maxillary Arch_2500_K2
CoexpressionAtlasBM Top 100 - parietal lobe

HCN1 RIMS3 KCNJ4 SCN1A

2.45e-0475864BM Top 100 - parietal lobe
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

CACNA1A STXBP5L KCNB2 CCNE1 SLC15A1 WNK3 WNK2

1.19e-07169101796a2aec9acf8a6f966973c035e5ade456cf47772
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

CACNA1A STXBP5L HCN1 KCNB2 GRM5 SCN8A HERC1

3.73e-07200101748d801219bc771d6c7e151dc88ca4c179988de85
ToppCelldroplet-Kidney-nan-3m-Epithelial-kidney_collecting_duct_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANO9 WNK1 CLDN8 SLC15A1 TESC WNK4

3.72e-061821016ccfee33de0faebbe69099d4ff3c3971f6a708b99
ToppCelldroplet-Lung-3m-Epithelial-airway_epithelial-neuroendocrine_cell|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

STXBP5L RIMS3 GRM5 SCN8A IGSF1 WNK2

3.96e-061841016e0e5a553fb8c0947679634396d20c2ca8455b932
ToppCelldroplet-Lung-3m-Epithelial-airway_epithelial-neuroendocrine_cell-neuroendocrine|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

STXBP5L RIMS3 GRM5 SCN8A IGSF1 WNK2

3.96e-061841016c3b848e1438a84b3fac8a4e40f3db478cc84d970
ToppCellfacs-Brain_Non-Myeloid-Cerebellum_-18m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A STXBP5L HCN1 SCN1A SCN8A TMEM240

3.96e-0618410167d9bcdaff8cbea4c50ab7db0f8e01f6bbd0ef593
ToppCelldroplet-Lung-immune-endo-depleted-3m-Epithelial-lung_neuroendocrine_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STXBP5L RIMS3 GRM5 SCN8A IGSF1 WNK2

4.08e-06185101630263c558ee331e0879abcf8b4c2427ff05f9fe7
ToppCelldroplet-Lung-immune-endo-depleted-3m-Epithelial-Neuroendocrine|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STXBP5L RIMS3 GRM5 SCN8A IGSF1 WNK2

4.08e-0618510161b000ca11970db8f347eb97ff44605d562aea70a
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CACNA1A STXBP5L HCN1 KCNB2 SCN8A WNK2

4.21e-061861016b45cce768e4bf91da194fd9660cab7520dfb15ac
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A STXBP5L GRM5 KCNJ4 SCN1A SCN8A

5.21e-061931016be28070c049e7cb68bcd54f582226eb2f5e4bc1c
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A STXBP5L GRM5 KCNJ4 SCN1A SCN8A

5.21e-0619310160c652ebe22ce5d2927599dd97ef1920547858395
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A STXBP5L GRM5 KCNJ4 SCN1A SCN8A

5.21e-0619310168689a70a33a7c3823dc647d41ac0160e7c3ae396
ToppCellHippocampus-Neuronal|Hippocampus / BrainAtlas - Mouse McCarroll V32

SH3BP1 GRM5 KCNJ9 SCN8A HERC2 HERC1

5.36e-0619410168aeb347b3024354c9505f4f0fddf0b843489dc6b
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA1A STXBP5L HCN1 GRM5 SCN1A SCN8A

6.03e-061981016c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1A STXBP5L HCN1 KCNB2 SCN8A WNK2

6.03e-0619810168f25e8dff42bad8e779ca618bdb1cb1610667962
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA1A STXBP5L HCN1 GRM5 SCN1A SCN8A

6.03e-0619810166d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA1A STXBP5L HCN1 GRM5 SCN1A SCN8A

6.03e-0619810164ca5ff320905ab4ff60ed90a5522227c782142a6
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1A STXBP5L HCN1 KCNB2 SCN8A WNK2

6.03e-061981016e3e0aa3ef20b2370f5b133048510677aaa562dfa
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

STXBP5L HCN1 KCNB2 GRM5 SCN8A HERC1

6.03e-0619810160ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCellCOVID-19-kidney-Technical/muscle_(PCT)|kidney / Disease (COVID-19 only), tissue and cell type

CACNA1A STXBP5L GRM5 FBN2 SCN1A

2.07e-051461015c55f1bdb6ac43b4118cb27ea7c879527e1afcbab
ToppCellPND10-Epithelial-Epithelial_Airway-Neurosecretory-Secretory-Secretory_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ANO9 RIMS3 CLDN8 C16orf89 SLC9A2

3.62e-0516410156ea188e17895961cd112152fb111d08641cc5e45
ToppCell3'-Child04-06-SmallIntestine-Epithelial-neuro-epithelial-L_cells_(PYY+)|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A DRD4 STXBP5L KCNB2 BBS9

3.94e-0516710155accd0bc7c95089feb2c09376d12cd8bd3773775
ToppCell10x_3'_v2v3-Neoplastic-Stem-like-OPC-like-OPC-like_Prolif-E|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

RIMS3 CCNE1 FAT1 SCN8A WNK3

4.17e-0516910152833a8a7094e4d407eb923f2bc59b9b112c6bae4
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)|Children_(3_yrs) / Lineage, Cell type, age group and donor

CACNA1A STXBP5L KCNB2 SLC15A1 WNK2

4.17e-051691015b6b5bb6408c1305a00719e1b88a5e1202081faf3
ToppCellBL-critical-LOC-Epithelial-Ionocyte|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

ADCY5 SLC9A2 SLC14A1 WNK3 PDE11A

4.29e-051701015b465df2dac6b4e98b4ede6ad0c6347656757885c
ToppCellTCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-8|TCGA-Liver / Sample_Type by Project: Shred V9

ACAT1 SLC10A1 KCNJ4 SLC22A1 SCN4A

4.41e-051711015c4a919fe3d56ae6df2fcab6686abacc10befc053
ToppCellfacs-Kidney-nan-18m-Epithelial-kidney_collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WNK1 CLDN8 SLC15A1 TESC WNK4

4.54e-051721015bc1b889ac5e07b8324ae5837eca911f9c865e959
ToppCellfacs-Kidney-nan-18m-Epithelial-kidney_collecting_duct_principal_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

WNK1 CLDN8 SLC15A1 TESC WNK4

4.54e-051721015ba70b6110b70afb1870e8dcaf58c507b8c7d918e
ToppCellBAL-Mild-Epithelial-Epithelial-AT1/AT2|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ADCY5 ST6GAL2 SLC9A2 WNK3 PDE11A

4.79e-051741015b7f5492ce8098f7eb0aef30ee558d00738d59d0e
ToppCellBAL-Mild-Epithelial-Epithelial-AT1/AT2-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

ADCY5 ST6GAL2 SLC9A2 WNK3 PDE11A

4.79e-05174101571730503be3d9c839c4c9e950145e2101d682a1c
ToppCellBAL-Mild-Epithelial-Epithelial-AT1/AT2|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

ADCY5 ST6GAL2 SLC9A2 WNK3 PDE11A

4.79e-051741015ee8ac51fa0b426ad7b7453371bb79c8bf8c1d358
ToppCellBAL-Mild-Epithelial-Epithelial-AT1/AT2-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ADCY5 ST6GAL2 SLC9A2 WNK3 PDE11A

4.79e-051741015cafe4d6b5f08d8888e9db6e196c66df991c03e7b
ToppCellAdult-Epithelial-lung_neuroendocrine_cell_(PNEC)|Adult / Lineage, Cell type, age group and donor

CACNA1A STXBP5L HCN1 KCNB2 RHBDL3

4.92e-0517510154db1a3c284488b3f6de7568363f176d74e2a4587
ToppCell5'-Adult-Distal_Rectal-Epithelial-goblet-BEST2+_Goblet_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLAMF9 GFPT1 SCN8A WNK4 WNK2

4.92e-051751015019ea30ac55748463d7917abf3d3f0e804189bfd
ToppCellAdult-Epithelial-lung_neuroendocrine_cell_(PNEC)-D231|Adult / Lineage, Cell type, age group and donor

CACNA1A STXBP5L HCN1 KCNB2 RHBDL3

4.92e-0517510158d9f44a2633b71fb4d2b4a7d9530f954e07c4a18
ToppCell3'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A HCN1 KCNB2 WNK4 PROC

5.63e-051801015d553aba594f5304f1c09ff9c6d49b64cd7ee7850
ToppCell5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte-Ionocyte_L.0.7.0.0|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADCY5 SLC9A2 SLC14A1 WNK2 PDE11A

5.78e-05181101540df0afcb6848202da54670e84f22d7c3a515d01
ToppCell5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte-Ionocyte|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADCY5 SLC9A2 SLC14A1 WNK2 PDE11A

5.78e-0518110152b53a65ca5616a7b9f64232c3e0b7212d1e2f063
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-neuro-epithelial-M/X_cells_(MLN/GHRL+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CACNA1A SLAMF9 STXBP5L KCNB2 WNK3

5.78e-051811015cb17c904ab86d56dd30cac9b61acbb3b76f84ded
ToppCell5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic-ionocyte|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADCY5 SLC9A2 SLC14A1 WNK2 PDE11A

5.78e-0518110156aef84616e8d2faf54b7e9e6cd02f33c3066dabc
ToppCell5'-Airway_Nasal-Epithelial-Neuro-endocrine/ionocytic|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ADCY5 SLC9A2 SLC14A1 WNK2 PDE11A

5.78e-05181101540d3829ae4aaf81e8616c3499ff8933137fc1cc4
ToppCellEpithelial-lung_neuroendocrine_cell_(PNEC)|World / Lineage, Cell type, age group and donor

CACNA1A STXBP5L HCN1 KCNB2 SCN8A

5.93e-05182101557bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCelldroplet-Heart-nan-24m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC24A3 ADCY5 FAT1 SLC9A2 TESC

6.25e-051841015f4344f3c407b2d4d703fe56e43d84dbfe60ba833
ToppCellfacs-Brain_Non-Myeloid-Cortex-24m|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A GRM5 KCNJ4 SCN1A SCN8A

6.57e-0518610157278a1a1bf9bb27aeb03852134defb31b62f30d6
ToppCellfacs-Brain_Non-Myeloid-Cerebellum-3m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STXBP5L HCN1 SCN1A KCNJ9 SCN8A

6.74e-0518710157b2cd0c618ed081223343f3bec2244c8723c9a31
ToppCellCOVID-19-kidney-DCT|kidney / Disease (COVID-19 only), tissue and cell type

SLC24A3 WNK1 KLHL13 TESC WNK4

6.91e-051881015df1fd0819d301679f3c9ea404e942e39095912eb
ToppCellFetal_29-31_weeks-Epithelial-lung_neuroendocrine_cell_(PNEC)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CACNA1A STXBP5L HCN1 KCNB2 SCN8A

6.91e-051881015c4c3b21ab723b0e9beff9ec84f8d68485f771528
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_5|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

SLAMF9 ACSF2 MS4A4E RCC2 TRMT6

7.64e-051921015dfb9101622f7d2f2c392e850cff07becfc8c655e
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_5|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

SLAMF9 ACSF2 MS4A4E RCC2 TRMT6

7.64e-051921015d39133cf1a20af6f2970188630fc3b27a4cfc9c5
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Neuronal-neuron|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RIMS3 KCNB2 GRM5 KCNJ4 KCNJ9

7.82e-051931015461919ab422bc9d1fcff7a3a4757c75239041d7e
ToppCellfacs-Brain_Non-Myeloid-Cortex-3m-Neuronal-nan|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RIMS3 KCNB2 GRM5 KCNJ4 KCNJ9

7.82e-0519310150dd810ad900d3e586551622b2c1de39d76fd6a7f
ToppCellPosterior_cortex-Neuronal|Posterior_cortex / BrainAtlas - Mouse McCarroll V32

STXBP5L SH3BP1 GRM5 SCN8A HERC1

7.82e-051931015b4989e3436e84dbec3789b46057e0f7a0ebf09d4
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

GRM5 ST6GAL2 FAT1 FBN2 PROC

8.02e-0519410158ddcaaf24cee6e30d5be52c0cbf778cfba309c53
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A SLC2A2 KMT2A FNIP1 HERC1

8.21e-0519510153e519cffa6144a62b06124642a14c9ff39b76554
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

CACNA1A STXBP5L RIMS3 SCN1A RHBDL3

8.21e-051951015787e95fb59c40bba784544b662fac37606ae1427
ToppCell367C-Myeloid-Macrophage-FABP4+_Macrophage|Myeloid / Donor, Lineage, Cell class and subclass (all cells)

ACAT1 GBP1 ABCG1 ATP6V1D CD81

8.21e-051951015f664fe18856065baaa2837fc82ea946e45f6fcc3
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CACNA1A SLC2A2 KMT2A FNIP1 HERC1

8.21e-0519510157796ea9247f4c63762f0de8490fed08b9717fa23
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_neuro-secretory|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ADCY5 SLC9A2 SLC14A1 RHBDL3 PDE11A

8.41e-051961015a4cc02ea41479d24044bd2ca6441f85d683c0ca9
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

STXBP5L HCN1 KCNB2 GRM5 SCN8A

8.41e-051961015676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCellTracheal-10x5prime-Epithelial-Epi_airway_neuro-secretory-Ionocyte_n_Brush|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

ADCY5 SLC9A2 SLC14A1 RHBDL3 PDE11A

8.41e-05196101550aaca81b593ff71790bb75403b2e4c3ab03a6d2
ToppCellBronchial-NucSeq-Epithelial-Epi_submucosal-gland-Myoepithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ADCY5 ST6GAL2 FBN2 KLHL13 WNK2

8.41e-051961015a58bdf9de05d13d84211e09a933679d485bf8ab4
ToppCellTracheal-10x3prime_v2-Epithelial-Epi_airway_neuro-secretory|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

CACNA1A ANO9 KCNB2 ADCY5 SCN8A

8.62e-051971015ff4df77117165b6b25315e29b0722cc136eba607
ToppCellTracheal-NucSeq-Epithelial-Epi_submucosal-gland-Myoepithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ADCY5 ST6GAL2 FAT1 FBN2 KLHL13

8.62e-051971015f0475ad9c09c6da418dba17d3d3c1aaa2ef9ab4e
ToppCellnormal_Pleural_Fluid-T/NK_cells-Exhausted_CD8+_T|T/NK_cells / Location, Cell class and cell subclass

GBP1 RNF213 PPP1CA CD81 TESC

8.62e-0519710152bf540fa228687a71f595a807e4a2af20588a82c
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

STXBP5L HCN1 GRM5 SCN1A SCN8A

8.83e-0519810158ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell5'-Adult-Distal_Rectal-Epithelial|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CLDN8 GFPT1 ST6GAL2 WNK4 WNK2

8.83e-0519810159c0535099750698daac5d6b4d39fb19fecf4ffde
ToppCellBronchus_Control_(B.)-Endothelial-TX-Bronchial_vessel|Bronchus_Control_(B.) / Sample group, Lineage and Cell type

KCNB2 FAT1 SLC15A1 RHBDL3 PDE11A

8.83e-051981015dcf334d13e5b0018fee24febccfef91c9e17843b
ToppCellSepsis-ICU-NoSEP-Myeloid-pDC|ICU-NoSEP / Disease, condition lineage and cell class

NPC1 DRD4 RIMS3 KLHL13 PROC

9.04e-051991015a199e67438eeed903d0996605591ec54400fdd66
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-OPC-OPC-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

STXBP5L GRM5 ST6GAL2 SCN1A WNK3

9.04e-05199101519a97e27a4758e794ce7246d295e112b47931a48
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-1_mon-Proliferating-Cycling_Progenitors|1_mon / Sample Type, Dataset, Time_group, and Cell type.

WNK1 RCC2 ST6GAL2 FAT1 KMT2A

9.04e-051991015358c4b3037f59378db8916a2fbe9ed4830cf1449
ToppCellStriatum-Neuronal|Striatum / BrainAtlas - Mouse McCarroll V32

GRM5 SCN1A KCNJ9 ATP6V1D HERC1

9.25e-052001015c888fd487990cad482a4ca47601cdebc0ca3f3ce
ToppCellMacroglial-Polydendrocytes-PDGFRA-|Macroglial / cells hierarchy compared to all cells using T-Statistic

CACNA1A STXBP5L SLC24A3 GRM5 SCN1A

9.25e-052001015f17b5a54e8f9eba9dcd0808ba4e8d275ac41bce2
ToppCellMacroglial-Polydendrocytes-PDGFRA--|Macroglial / cells hierarchy compared to all cells using T-Statistic

CACNA1A STXBP5L SLC24A3 GRM5 SCN1A

9.25e-052001015cc3409518f8b436ea92deb955e81114b3f410ff7
ToppCellMacroglial-Polydendrocytes-PDGFRA|Macroglial / cells hierarchy compared to all cells using T-Statistic

CACNA1A STXBP5L SLC24A3 GRM5 SCN1A

9.25e-052001015c24a3099e3d96d8b72f6d05286bb355d661a0377
ToppCellMacroglial-Polydendrocytes-PDGFRA---|Macroglial / cells hierarchy compared to all cells using T-Statistic

CACNA1A STXBP5L SLC24A3 GRM5 SCN1A

9.25e-0520010154fc3de4bff7ed2bf40b38462c4b4e9b87af6a4ca
ToppCellMacroglial-Polydendrocytes-PDGFRA----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

CACNA1A STXBP5L SLC24A3 GRM5 SCN1A

9.25e-052001015310cd53db1c137f6af74e6ae682221d7ac27310c
ToppCellMacroglial-Polydendrocytes|Macroglial / cells hierarchy compared to all cells using T-Statistic

CACNA1A STXBP5L SLC24A3 GRM5 SCN1A

9.25e-052001015961858738ce35db8760c8c2e136f8369bc444ccf
ToppCellLPS_only-Unknown-Endothelial|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PDE6A RIMS3 ADCY5 SLC10A6

1.37e-041151014ad5298c2ad8bf94fa13c2e50b0799e929473ef59
ToppCellLPS_only-Unknown|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PDE6A RIMS3 ADCY5 SLC10A6

1.37e-0411510147a733f6987b40ec497a03734b79ed5355ad3a2fc
ToppCellLPS_only-Unknown-Endothelial-Pericyte_2|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PDE6A RIMS3 ADCY5 SLC10A6

1.37e-041151014c67145d3cd9243994a141749b426ff2a6dcc8d93
ToppCellParenchymal-10x5prime-Immune_Myeloid-Myeloid|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SLC24A3 ZNF395 CCNE1 SLC14A1

1.46e-041171014f0c738b6b850733f9af68704172554177a1c1198
ToppCellParenchymal-10x5prime-Immune_Myeloid-Myeloid-Megakaryocyte|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

SLC24A3 ZNF395 CCNE1 SLC14A1

1.46e-041171014b5cb9d69ddd42331134f7e4bd51bd1c31030893c
ToppCellControl-Lymphocytic_NKT-T_cells-Erythroid|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CCNE1 SLC14A1 SCN4A TESC

1.94e-041261014f582c3ed43209dca3538e60062b3edd59bf2ad6b
ToppCell(09)_Ionocytes|World / shred by cell type and Timepoint

ADCY5 ATP6V1D CD81 PDE11A

2.53e-041351014237b9b646513ca6e4b754c0da95d24015b3661f7
ToppCellLPS-antiTNF-Hematopoietic_Meg-Ery-Mes-Epi-like|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CACNA1A GRM5 SLC10A1 CHCHD1

2.60e-041361014a2063abe2d7c3277bfbe1514c8c66363cf04b248
Drugsodium

HCN1 SLC24A3 WNK1 ADCY5 GFPT1 SLC2A2 PPP1CA SLC9A2 SLC10A1 SLC15A1 KCNJ4 KCNJ9 ATP6V1D SCN4A SLC10A6 TESC WNK4 WNK3 PROC

1.04e-089449519CID000000923
Drugamiloride

CACNA1A HCN1 SLC24A3 WNK1 PPP1CA SLC9A2 SLC14A1 SCN4A WNK4 WNK3

7.97e-073159510CID000016230
Drugpotassium

CACNA1A ACAT1 HCN1 SLC24A3 KCNB2 GRM5 WNK1 ADCY5 SLC2A2 SLC9A2 SLC14A1 KCNJ4 KCNJ9 SCN4A WNK4 WNK3

3.98e-0610089516CID000000813
Diseasepseudohypoaldosteronism (implicated_via_orthology)

WNK1 WNK4 WNK3 WNK2

1.57e-096964DOID:4479 (implicated_via_orthology)
DiseaseTremor, Rubral

NPC1 CACNA1A HCN1 SCN8A

1.86e-0716964C0750940
DiseaseAtaxia, Appendicular

NPC1 CACNA1A HCN1 SCN8A

1.86e-0716964C0750937
DiseaseAtaxia, Motor

NPC1 CACNA1A HCN1 SCN8A

1.86e-0716964C0278161
DiseaseAtaxia, Sensory

NPC1 CACNA1A HCN1 SCN8A

1.86e-0716964C0240991
DiseaseAbnormal coordination

NPC1 CACNA1A HCN1 SCN8A

1.86e-0716964C0520966
DiseaseAtaxia, Truncal

NPC1 CACNA1A HCN1 SCN8A

1.86e-0716964C0427190
DiseaseAtaxia

NPC1 CACNA1A HCN1 SCN8A

1.26e-0625964C0004134
Diseasegeneralized epilepsy with febrile seizures plus 2 (implicated_via_orthology)

SCN1A SCN4A SCN8A

3.94e-0610963DOID:0111294 (implicated_via_orthology)
DiseaseDravet syndrome (implicated_via_orthology)

SCN1A SCN4A SCN8A

3.94e-0610963DOID:0080422 (implicated_via_orthology)
Diseasegeneralized epilepsy with febrile seizures plus (implicated_via_orthology)

SCN1A SCN4A SCN8A

7.19e-0612963DOID:0060170 (implicated_via_orthology)
DiseaseMEHMO syndrome (implicated_via_orthology)

EIF2S3B EIF2S3

1.05e-052962DOID:0060801 (implicated_via_orthology)
DiseaseNeurodevelopmental Disorders

KMT2E ADCY5 SCN1A SCN8A KMT2A

1.36e-0593965C1535926
DiseaseFamilial or sporadic hemiplegic migraine

CACNA1A SCN1A

3.14e-053962cv:CN295307
DiseaseFamilial hemiplegic migraine

CACNA1A SCN1A

3.14e-053962cv:C0338484
DiseasePseudohypoaldosteronism type 2A

WNK1 WNK4

6.26e-054962cv:C1840389
DiseasePseudohypoaldosteronism, type 2

WNK1 WNK4

6.26e-054962cv:C1449844
Diseasehypopituitarism (implicated_via_orthology)

EIF2S3B EIF2S3

1.56e-046962DOID:9406 (implicated_via_orthology)
DiseaseEPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 1

HCN1 SCN1A

1.56e-046962C3463992
Diseaseepilepsy (implicated_via_orthology)

CACNA1A SLC24A3 SCN1A SCN4A SCN8A

1.97e-04163965DOID:1826 (implicated_via_orthology)
Diseasebutyrylcarnitine (C4) measurement

SPPL3 SLC22A1

2.90e-048962EFO_0800201
DiseaseX-linked infantile spasms

HCN1 SCN1A

2.90e-048962C4552072
Diseasepseudohypoaldosteronism (is_implicated_in)

WNK1 WNK4

2.90e-048962DOID:4479 (is_implicated_in)
Diseasemultiple system atrophy

PKHD1L1 FBXO47 FBN2

3.02e-0440963EFO_1001050
Diseaseleukodystrophy (implicated_via_orthology)

EIF2S3B EIF2S3

3.72e-049962DOID:10579 (implicated_via_orthology)
DiseaseGeneralized Epilepsy with Febrile Seizures Plus

HCN1 SCN1A

3.72e-049962C3502809
Diseasetype 2 diabetes mellitus (implicated_via_orthology)

SLC2A2 PPP1CA PPP1CC OGA

3.91e-04105964DOID:9352 (implicated_via_orthology)
DiseaseEpilepsy

HCN1 EIF2S3 SCN1A SCN8A

4.51e-04109964C0014544
Diseasegout

OR13C8 OR13C3 ABCG1 FAT1 SLC22A1

4.60e-04196965EFO_0004274
DiseasePseudohypoaldosteronism, Type I

WNK1 WNK4

4.63e-0410962C0268436
DiseaseCongenital myasthenic syndrome

GFPT1 SCN4A

4.63e-0410962cv:C0751882
Diseasehair colour measurement, eye colour measurement, skin pigmentation measurement

GRM5 HERC2

4.63e-0410962EFO_0007009, EFO_0007822, EFO_0009764
DiseasePseudohypoaldosteronism

WNK1 WNK4

4.63e-0410962C0033805
DiseaseHyperpotassemia and Hypertension, Familial

WNK1 WNK4

4.63e-0410962C2713447
DiseasePseudohypoaldosteronism, Type I, Autosomal Recessive

WNK1 WNK4

4.63e-0410962C1449843
DiseasePseudohypoaldosteronism, Type II

WNK1 WNK4

4.63e-0410962C1449844
DiseasePseudohypoaldosteronism, Type I, Autosomal Dominant

WNK1 WNK4

4.63e-0410962C1449842
Diseasechronic kidney disease, Proteinuria

CACNA1A KMT2A

5.65e-0411962EFO_0003884, HP_0000093
DiseaseHOMA-B

ADCY5 SLC2A2 SLC22A1

7.74e-0455963EFO_0004469
DiseaseHepatitis C

CD81 IFNL3

1.07e-0315962C0019196
DiseaseMyasthenic Syndromes, Congenital, Slow Channel

GFPT1 SCN4A

1.22e-0316962C0751885
Diseasephysical activity measurement

NPC1 GRM5 TESC HERC1 PROC

1.25e-03245965EFO_0008002
DiseaseCongenital Myasthenic Syndromes, Postsynaptic

GFPT1 SCN4A

1.38e-0317962C0751883
Diseasemigraine disorder, systolic blood pressure

RNF213 SLC24A3

1.55e-0318962EFO_0006335, MONDO_0005277
DiseaseFebrile seizure (within the age range of 3 months to 6 years)

SCN1A HERC1

1.55e-0318962HP_0002373
DiseaseMyeloid Leukemia

KMT2E KMT2A

1.55e-0318962C0023470
DiseaseLeukemia, Monocytic, Chronic

KMT2E KMT2A

1.55e-0318962C0023466
DiseaseCongenital Myasthenic Syndromes, Presynaptic

GFPT1 SCN4A

1.73e-0319962C0751884
DiseaseAttention Deficit Disorder

DRD4 GRM5

2.32e-0322962C0041671
DiseaseMinimal Brain Dysfunction

DRD4 GRM5

2.32e-0322962C1321905
Diseaseanxiety disorder (implicated_via_orthology)

HCN1 SCN1A

2.32e-0322962DOID:2030 (implicated_via_orthology)
DiseaseEpilepsy, Cryptogenic

HCN1 SCN1A SCN8A

2.45e-0382963C0086237
DiseaseAwakening Epilepsy

HCN1 SCN1A SCN8A

2.45e-0382963C0751111
DiseaseAura

HCN1 SCN1A SCN8A

2.45e-0382963C0236018
DiseaseBMI-adjusted fasting blood glucose measurement

ADCY5 SLC2A2

2.53e-0323962EFO_0008036
DiseaseMyasthenic Syndromes, Congenital

GFPT1 SCN4A

2.76e-0324962C0751882
DiseaseAttention deficit hyperactivity disorder

DRD4 GRM5

2.76e-0324962C1263846
Diseaseparacentral lobule volume measurement

STXBP5L SLC15A1

2.99e-0325962EFO_0010317
Diseasedepressive symptom measurement, response to antidepressant

NLRP1 DHX8 TGM4

3.00e-0388963EFO_0007006, GO_0036276

Protein segments in the cluster

PeptideGeneStartEntry
IEACVMMLLSEGMKE

BARGIN

301

Q6ZT62
EMCILMVIAMSSIAL

CACNA1A

1246

O00555
PTRDIFMENIMFCGM

C16orf89

246

Q6UX73
MACLMAAFSVGTAMN

ABCG1

1

P45844
MAAMYTCDIMATGDV

EFL1

981

Q7Z2Z2
CVMMLLSEGMKEEGL

SH3BP1

296

Q9Y3L3
CSGDEILTMELMIMK

CCNE1

221

P24864
VAGTMMCLMYGATLI

ACSF2

316

Q96CM8
CCVEMGMDMIEAISL

ADCY5

536

O95622
HASGCMMDLFVQMAI

ANO9

466

A1A5B4
MIFEMILSMVLCCGI

CD81

216

P60033
SAMLIMAEEKALAMG

HADHB

316

P55084
ITKMACGAEFSMIMD

RCC2

256

Q9P258
GSMVNAFMVGCMFVK

KCNJ9

146

Q92806
CVIDSFMIGTIMAKM

KCNJ4

161

P48050
EDSCFMIDMETGMLK

FAT1

761

Q14517
FAMGATECVLLSMMA

OR13C6P

106

Q8NH95
FAMGATECVLLSMMA

OR13C7

106

P0DN81
CFCEGMTVRGLLMAM

GRM5

276

P41594
AMASPMNGEECMLAV

HERC2

3441

O95714
EGMISFDCFMTILMQ

HERC1

291

Q15751
MTQSMCGFLMVVAGI

OR4C45

131

A6NMZ5
ICAVFFMAMIANGVM

OR2T6

31

Q8NHC8
IGMACVDTMMLEALA

OR2W6P

191

Q8NHA6
DAMITAALRMFMELG

PDE11A

621

Q9HCR9
VMAMMMTACDLSAIT

PDE6A

711

P16499
MGMCVETDMELLVCT

NLRP1

741

Q9C000
FTVDCSKAGTNMMMV

FLNC

2656

Q14315
IGMSGMFVCAIFMSV

SLC2A2

371

P11168
CLMQDDTRGMFMETT

KMT2E

1106

Q8IZD2
MASEIHMTGPMCLIE

GBP1

1

P32455
FAMAGTECLLLSMMA

OR2S2

106

Q9NQN1
IHAFCMMESTVLLAM

OR52P1

106

Q8NH57
AMGTTECVLLGMMAF

OR13C2

106

Q8NGS9
LMAMDVMLCTASIFN

DRD4

111

P21917
CMASLIVARQGMGDM

SLC24A3

526

Q9HC58
LICIQSMDGMLMVFE

BBS9

151

Q3SYG4
IMCATIAMVLVNMFG

NPC1

1126

O15118
AMKGDMNLSIVMTTC

SLC10A1

111

Q14973
VMSNMVSENMLCAGI

PROC

376

P04070
AMMSVDETLMCSFQI

PPP1CA

281

P62136
DNAGGMMSVDETLMC

PPP1CB

276

P62140
MMSVDETLMCSFQIL

PPP1CB

281

P62140
GEATCITEMSVMMAC

CHCHD1

41

Q96BP2
MLSMIVGATCYAMFV

HCN1

376

O60741
FCIRMSLGMTSIVMD

IGSF1

21

Q8N6C5
AMFTGGMKEQDLMCI

KLHL13

121

Q9P2N7
GKLHMMEEMCALSFG

KCNB2

106

Q92953
AMCMTVTCGILLLVM

GFRAL

356

Q6UXV0
RCSSDANMLGEMMFG

FNIP1

121

Q8TF40
MTLESMMACCLSDEV

GNA11

1

P29992
MTGDCMPVLVLMAAV

IFNL3

1

Q8IZI9
SSEMAIMMGADAKIL

DENND4C

1066

Q5VZ89
MGIIMMCVAFSSYEE

MS4A4E

61

Q96PG1
FACVIMEMLQSIMSG

FBXO47

401

Q5MNV8
MMIGSMTIDCLGILN

KMT2A

2021

Q03164
LMATMLNGAAVMDAA

EIF2S3B

141

Q2VIR3
ESRGMMCKNLIGTFM

FBN2

2306

P35556
MAVGMVLASMAFVVA

SLC15A1

361

P46059
MAMSNLLAGAACLVM

SLC22A1

406

O15245
CLMMDFGDSSGVEMR

PKD1L1

321

Q8TDX9
RNMFSICSAVMVMAL

MFSD5

406

Q6N075
KMLIMSVHLGCSEEM

DHX8

991

Q14562
AMGSTECLLLGMMAF

OR13C3

136

Q8NGS6
GCMVQMFISFAMGAT

OR13C8

96

Q8NGS7
MFISFAMGATECMIL

OR13C8

101

Q8NGS7
AMGATECMILGTMAL

OR13C8

106

Q8NGS7
AMGTTECVLLGMMAF

OR13C9

106

Q8NGT0
AMVEMMSVLPLSLCG

OR13F1

156

Q8NGS4
DMSLSDNASMCLMSI

UTP20

1486

O75691
CAMMMGCVIERAFKD

MRPL39

146

Q9NYK5
AMCLTVFLMVMVIGN

SCN4A

776

P35499
VSLVMFALMMCDDRI

GFPT1

501

Q06210
AAKFEEMCGLVMGMF

OGA

611

O60502
EMCGLVMGMFTRLSN

OGA

616

O60502
LRMAVALICMSMEFG

RHBDL3

306

P58872
KCFMGMAQIMLDELD

RIMS3

251

Q9UJD0
EGTEAAAATAAIMMM

SERPINB6

326

P35237
SGFIGILIMMSMCRE

ST6GAL2

436

Q96JF0
CASGMKAIMMASQSL

ACAT1

126

P24752
MCAMMSFEKGQGVLI

TGM4

216

P49221
CGLMTAMIKMVFIAQ

OR6Y1

156

Q8NGX8
VLTFSCMDRMGGLMQ

STXBP5L

896

Q9Y2K9
EVAGQAMCLTVFMMV

SCN1A

961

P35498
MMAILGMKCTRCTGD

CLDN8

96

P56748
SIADGAMMEAASVCM

TESC

156

Q96BS2
MTLDAFAAMACTEML

RNF213

3856

Q63HN8
MILGASVVMAIACLM

TMEM240

11

Q5SV17
SVVMAIACLMDMNAL

TMEM240

16

Q5SV17
SGIMAITACAMTMNK

SLC9A2

331

Q9UBY0
MDALAMGLCVAMIAF

SPPL3

166

Q8TCT6
VCLTTLVIMGSMAVM

TMEM121

11

Q9BTD3
MLMGEVMREAAFSLA

ATP6V1D

56

Q9Y5K8
DEMMAAMVLTSLSCS

ZNF395

166

Q9H8N7
EVAGQAMCLIVFMMV

SCN8A

946

Q9UQD0
MMGLLMFSLGCSVEI

SLC10A6

41

Q3KNW5
CFGMEYAMMVIESLD

PKHD1L1

3761

Q86WI1
SMSLVCSVEKAGMDM

SLAMF9

151

Q96A28
SLACIAMGGMFMALT

SLC14A1

291

Q13336
AMMSVDETLMCSFQI

PPP1CC

281

P36873
CELLHSMVMFMLGKA

PRKDC

931

P78527
METCAGLVLGAMMER

TRMT6

206

Q9UJA5
LMDCTVSTGAAAMMA

UCKL1

451

Q9NWZ5
ESVDVYAFGMCMLEM

WNK1

401

Q9H4A3
SVDVYAFGMCMLEMA

WNK2

376

Q9Y3S1
VDVYAFGMCMLEMAT

WNK4

356

Q96J92
VYAFGMCMLEMATSE

WNK3

331

Q9BYP7
LMATMLNGAAVMDAA

EIF2S3

141

P41091