Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionG protein-coupled serotonin receptor binding

GNAI1 GNAI3

6.12e-055502GO:0031821
GeneOntologyMolecularFunctionlipid transfer activity

ATG2B MTTP ATG2A

3.93e-0457503GO:0120013
GeneOntologyMolecularFunctionhelicase activity

EIF4A1 MCM9 DHX35 DDX60L

6.55e-04158504GO:0004386
GeneOntologyMolecularFunctionpotassium ion leak channel activity

KCNK10 KCNK2

7.21e-0416502GO:0022841
GeneOntologyMolecularFunctionRNA helicase activity

EIF4A1 DHX35 DDX60L

9.85e-0478503GO:0003724
GeneOntologyMolecularFunctionGTPase activating protein binding

GNAI1 GNAI3

1.02e-0319502GO:0032794
GeneOntologyMolecularFunctionnarrow pore channel activity

KCNK10 KCNK2

1.02e-0319502GO:0022842
GeneOntologyMolecularFunctionleak channel activity

KCNK10 KCNK2

1.02e-0319502GO:0022840
GeneOntologyMolecularFunctionATP-dependent activity, acting on RNA

EIF4A1 DHX35 DDX60L

1.06e-0380503GO:0008186
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

KCNJ8 KCNK10 KCNK2 ANO1

1.11e-03182504GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

KCNJ8 KCNK10 KCNK2 ANO1

1.15e-03184504GO:0022832
GeneOntologyMolecularFunctionlipid transporter activity

ATG2B ANO1 MTTP ATG2A

1.46e-03196504GO:0005319
GeneOntologyMolecularFunctionmonoatomic cation channel activity

KCNJ8 KCNK10 KCNK2 ANO1 UNC80

1.63e-03343505GO:0005261
GeneOntologyMolecularFunctionG-protein beta/gamma-subunit complex binding

GNAI1 GNAI3

1.78e-0325502GO:0031683
GeneOntologyMolecularFunctionoutward rectifier potassium channel activity

KCNK10 KCNK2

2.07e-0327502GO:0015271
GeneOntologyMolecularFunctionvoltage-gated potassium channel activity

KCNJ8 KCNK10 KCNK2

2.13e-03102503GO:0005249
GeneOntologyMolecularFunctionGDP binding

GNAI1 GNAI3 PCK1

2.19e-03103503GO:0019003
GeneOntologyMolecularFunctionribonucleoside triphosphate phosphatase activity

EIF4A1 MCM9 DHX35 GNAI1 GNAI3 DDX60L DNAH9

3.01e-03775507GO:0017111
GeneOntologyMolecularFunctionpotassium channel activity

KCNJ8 KCNK10 KCNK2

4.05e-03128503GO:0005267
GeneOntologyMolecularFunctionATP-dependent activity

KCNJ8 EIF4A1 MCM9 DHX35 DDX60L DNAH9

4.15e-03614506GO:0140657
GeneOntologyMolecularFunctiontransporter activity

SLC8A3 KCNJ8 ATG2B KCNK10 KCNK2 ANO1 MTTP ATG2A UNC80

4.29e-031289509GO:0005215
GeneOntologyMolecularFunctionpyrophosphatase activity

EIF4A1 MCM9 DHX35 GNAI1 GNAI3 DDX60L DNAH9

4.66e-03839507GO:0016462
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides

EIF4A1 MCM9 DHX35 GNAI1 GNAI3 DDX60L DNAH9

4.69e-03840507GO:0016817
GeneOntologyMolecularFunctionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides

EIF4A1 MCM9 DHX35 GNAI1 GNAI3 DDX60L DNAH9

4.69e-03840507GO:0016818
GeneOntologyMolecularFunctionATP hydrolysis activity

EIF4A1 MCM9 DHX35 DDX60L DNAH9

4.81e-03441505GO:0016887
GeneOntologyMolecularFunctionprotein-membrane adaptor activity

ATG2B ATG2A

5.68e-0345502GO:0043495
GeneOntologyMolecularFunctionmonoatomic ion channel activity

KCNJ8 KCNK10 KCNK2 ANO1 UNC80

5.69e-03459505GO:0005216
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC8A3 KCNJ8 KCNK10 KCNK2 ANO1 UNC80

6.06e-03664506GO:0008324
GeneOntologyMolecularFunctionphosphatidylinositol-3-phosphate binding

ATG2B ATG2A

6.44e-0348502GO:0032266
GeneOntologyMolecularFunctionvoltage-gated monoatomic cation channel activity

KCNJ8 KCNK10 KCNK2

6.52e-03152503GO:0022843
GeneOntologyBiologicalProcesskidney development

PROM1 FREM2 DCHS2 PDGFB KCNJ8 C3AR1 PAX2

3.90e-05372527GO:0001822
GeneOntologyBiologicalProcessglomerulus development

PROM1 PDGFB C3AR1 PAX2

4.24e-0577524GO:0032835
GeneOntologyBiologicalProcessrenal system development

PROM1 FREM2 DCHS2 PDGFB KCNJ8 C3AR1 PAX2

4.93e-05386527GO:0072001
GeneOntologyBiologicalProcessnephron development

PROM1 DCHS2 PDGFB C3AR1 PAX2

7.61e-05174525GO:0072006
GeneOntologyBiologicalProcessintermembrane lipid transfer

ATG2B MTTP ATG2A

8.56e-0534523GO:0120009
GeneOntologyBiologicalProcesspositive regulation of epithelial cell differentiation involved in kidney development

PROM1 PAX2

1.30e-047522GO:2000698
GeneOntologyBiologicalProcesspositive regulation of glomerular mesangial cell proliferation

PDGFB C3AR1

1.73e-048522GO:0072126
GeneOntologyCellularComponentphagophore

ATG2B ATG2A

1.68e-053502GO:0061908
DomainATG_C

VPS13C ATG2B ATG2A

1.91e-075513PF09333
DomainAutophagy-rel_C

VPS13C ATG2B ATG2A

1.91e-075513IPR015412
DomainVPS13_N

VPS13C ATG2B ATG2A

1.06e-068513IPR026854
DomainChorein_N

VPS13C ATG2B ATG2A

1.06e-068513PF12624
Domain2pore_dom_K_chnl_TREK

KCNK10 KCNK2

7.31e-062512IPR003976
DomainATG2

ATG2B ATG2A

7.31e-062512IPR026849
DomainATG2_CAD

ATG2B ATG2A

7.31e-062512PF13329
DomainATG2_CAD_motif

ATG2B ATG2A

7.31e-062512IPR026885
DomainPax2_C

PAX2 PAX5

2.19e-053512IPR022130
DomainPax2_C

PAX2 PAX5

2.19e-053512PF12403
DomainCalx_beta

FREM2 SLC8A3

2.03e-048512SM00237
DomainGprotein_alpha_I

GNAI1 GNAI3

2.03e-048512IPR001408
DomainCalx_beta

FREM2 SLC8A3

2.60e-049512IPR003644
DomainPAX

PAX2 PAX5

2.60e-049512SM00351
DomainPaired_dom

PAX2 PAX5

2.60e-049512IPR001523
DomainPAIRED_2

PAX2 PAX5

2.60e-049512PS51057
DomainPAX

PAX2 PAX5

2.60e-049512PF00292
DomainPAIRED_1

PAX2 PAX5

2.60e-049512PS00034
DomainCalx-beta

FREM2 SLC8A3

2.60e-049512PF03160
Domain2pore_dom_K_chnl

KCNK10 KCNK2

7.50e-0415512IPR003280
DomainG-alpha

GNAI1 GNAI3

8.56e-0416512PF00503
DomainGproteinA_insert

GNAI1 GNAI3

8.56e-0416512IPR011025
Domain-

GNAI1 GNAI3

8.56e-04165121.10.400.10
DomainG_alpha

GNAI1 GNAI3

8.56e-0416512SM00275
Domain-

EIF4A1 MCM9 DHX35 GNAI1 GNAI3 DDX60L DNAH9 ELP4

8.67e-047465183.40.50.300
DomainGprotein_alpha_su

GNAI1 GNAI3

9.68e-0417512IPR001019
DomainDEAD/DEAH_box_helicase_dom

EIF4A1 DHX35 DDX60L

1.04e-0373513IPR011545
DomainDEAD

EIF4A1 DHX35 DDX60L

1.04e-0373513PF00270
DomainK_chnl_dom

KCNK10 KCNK2

1.49e-0321512IPR013099
DomainIon_trans_2

KCNK10 KCNK2

1.49e-0321512PF07885
DomainP-loop_NTPase

EIF4A1 MCM9 DHX35 GNAI1 GNAI3 DDX60L DNAH9 ELP4

1.96e-03848518IPR027417
DomainHelicase_C

EIF4A1 DHX35 DDX60L

3.12e-03107513PF00271
DomainHELICc

EIF4A1 DHX35 DDX60L

3.12e-03107513SM00490
DomainHelicase_C

EIF4A1 DHX35 DDX60L

3.20e-03108513IPR001650
DomainHELICASE_CTER

EIF4A1 DHX35 DDX60L

3.29e-03109513PS51194
DomainHELICASE_ATP_BIND_1

EIF4A1 DHX35 DDX60L

3.29e-03109513PS51192
DomainDEXDc

EIF4A1 DHX35 DDX60L

3.29e-03109513SM00487
DomainHelicase_ATP-bd

EIF4A1 DHX35 DDX60L

3.37e-03110513IPR014001
DomainCA

FREM2 DCHS2 DSG2

3.82e-03115513SM00112
DomainCadherin

FREM2 DCHS2 DSG2

4.11e-03118513IPR002126
PathwayWP_ID_SIGNALING

PAX2 ELK3 PAX5

1.54e-0516443M39359
PathwayPID_S1P_S1P1_PATHWAY

PDGFB GNAI1 GNAI3

3.63e-0521443M103
PathwayPID_S1P_S1P3_PATHWAY

PDGFB GNAI1 GNAI3

9.80e-0529443M55
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PROK2_TO_PROK_PRKR_GI_ERK_SIGNALING_PATHWAY

GNAI1 GNAI3

2.63e-048442M47642
PathwayKEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PROKR2_TO_PROK_PRKR_GI_ERK_SIGNALING_PATHWAY

GNAI1 GNAI3

2.63e-048442M47643
PathwayKEGG_MEDICUS_REFERENCE_PROK_PRKR_GI_ERK_SIGNALING_PATHWAY

GNAI1 GNAI3

3.38e-049442M47641
PathwayWP_ID_SIGNALING_PATHWAY

PAX2 ELK3 PAX5

5.02e-0450443MM15817
PathwayKEGG_MEDICUS_ENV_FACTOR_NICOTINE_NNK_TO_PI3K_SIGNALING_PATHWAY

GNAI1 GNAI3

5.14e-0411442M47797
PathwayREACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS

KCNK10 KCNK2

5.14e-0411442MM14547
PathwayREACTOME_TANDEM_PORE_DOMAIN_POTASSIUM_CHANNELS

KCNK10 KCNK2

6.16e-0412442M1071
PathwayKEGG_MEDICUS_REFERENCE_CXCR4_GNAI_PI3K_BAD_SIGNALING_PATHWAY

GNAI1 GNAI3

6.16e-0412442M47558
PathwayKEGG_MEDICUS_PATHOGEN_HIV_GP120_TO_CXCR4_GNAI_PI3K_BAD_SIGNALING_PATHWAY

GNAI1 GNAI3

6.16e-0412442M47559
PathwayPID_SHP2_PATHWAY

PDGFB GNAI1 GNAI3

7.38e-0457443M100
PathwayPID_S1P_S1P4_PATHWAY

GNAI1 GNAI3

8.46e-0414442M64
PathwayREACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY

GNAI1 GNAI3

8.46e-0414442MM14669
PathwayREACTOME_ADENYLATE_CYCLASE_INHIBITORY_PATHWAY

GNAI1 GNAI3

8.46e-0414442M750
PathwayKEGG_MEDICUS_REFERENCE_CX3CR1_GNAI_AC_PKA_SIGNALING_PATHWAY

GNAI1 GNAI3

1.26e-0317442M47544
PathwayREACTOME_PHASE_4_RESTING_MEMBRANE_POTENTIAL

KCNK10 KCNK2

1.57e-0319442M27452
PathwayREACTOME_PHASE_4_RESTING_MEMBRANE_POTENTIAL

KCNK10 KCNK2

1.57e-0319442MM15194
PathwayREACTOME_NEURONAL_SYSTEM

KCNJ8 SIPA1L1 KCNK10 KCNK2 GNAI1 GNAI3

1.64e-03411446M735
Pubmed

Dermatofibrosarcoma protuberans with a novel COL6A3-PDGFD fusion gene and apparent predilection for breast.

COL6A3 PDGFB

2.19e-06252230014607
Pubmed

Atg2A/B deficiency switches cytoprotective autophagy to non-canonical caspase-8 activation and apoptosis.

ATG2B ATG2A

2.19e-06252228800131
Pubmed

AMP-activated protein kinase inhibits TREK channels.

KCNK10 KCNK2

2.19e-06252219840997
Pubmed

Modulation of K2P 2.1 and K2P 10.1 K(+) channel sensitivity to carvedilol by alternative mRNA translation initiation.

KCNK10 KCNK2

2.19e-06252225168769
Pubmed

Expression and effects of modulation of the K2P potassium channels TREK-1 (KCNK2) and TREK-2 (KCNK10) in the normal human ovary and epithelial ovarian cancer.

KCNK10 KCNK2

2.19e-06252223479219
Pubmed

Mammalian Atg2 proteins are essential for autophagosome formation and important for regulation of size and distribution of lipid droplets.

ATG2B ATG2A

2.19e-06252222219374
Pubmed

Identification of two promoters for human D-amino acid oxidase gene: implication for the differential promoter regulation mediated by PAX5/PAX2.

PAX2 PAX5

2.19e-06252225500505
Pubmed

DNA damage response in CD133 + stem/progenitor cells from umbilical cord blood: low level of endogenous foci and high recruitment of 53BP1.

PROM1 TP53BP1

2.19e-06252223206244
Pubmed

Extracellular acidification exerts opposite actions on TREK1 and TREK2 potassium channels via a single conserved histidine residue.

KCNK10 KCNK2

2.19e-06252219667202
Pubmed

The glycine hinge of transmembrane segment 2 modulates the subcellular localization and gating properties in TREK channels.

KCNK10 KCNK2

2.19e-06252228676394
Pubmed

The human genome encodes at least three non-allellic G proteins with alpha i-type subunits.

GNAI1 GNAI3

2.19e-0625222440724
Pubmed

Formation of Functional Heterodimers by TREK-1 and TREK-2 Two-pore Domain Potassium Channel Subunits.

KCNK10 KCNK2

2.19e-06252227129242
Pubmed

Pax2 and homeodomain proteins cooperatively regulate a 435 bp enhancer of the mouse Pax5 gene at the midbrain-hindbrain boundary.

PAX2 PAX5

2.19e-06252210662641
Pubmed

Migraine-Associated TRESK Mutations Increase Neuronal Excitability through Alternative Translation Initiation and Inhibition of TREK.

KCNK10 KCNK2

2.19e-06252230573346
Pubmed

Requirement of Gαi1 and Gαi3 in interleukin-4-induced signaling, macrophage M2 polarization and allergic asthma response.

GNAI1 GNAI3

2.19e-06252233754034
Pubmed

Diagnostic utility of PAX2 and PAX5 in distinguishing non-small cell lung cancer from small cell lung cancer.

PAX2 PAX5

2.19e-06252226823795
Pubmed

A conserved ATG2-GABARAP family interaction is critical for phagophore formation.

ATG2B ATG2A

6.57e-06352232009292
Pubmed

Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in splenocytes by Galphai proteins.

GNAI1 GNAI3

6.57e-06352216962188
Pubmed

The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway.

GNAI1 GNAI3

6.57e-0635228626678
Pubmed

Phospholipase D2 specifically regulates TREK potassium channels via direct interaction and local production of phosphatidic acid.

KCNK10 KCNK2

6.57e-06352225197053
Pubmed

Lipopolysaccharide- and gram-positive bacteria-induced cellular inflammatory responses: role of heterotrimeric Galpha(i) proteins.

GNAI1 GNAI3

6.57e-06352215788486
Pubmed

How ion channels sense mechanical force: insights from mechanosensitive K2P channels TRAAK, TREK1, and TREK2.

KCNK10 KCNK2

6.57e-06352226332952
Pubmed

Role of the TREK2 potassium channel in cold and warm thermosensation and in pain perception.

KCNK10 KCNK2

6.57e-06352225239074
Pubmed

Differential regulation of lipopolysaccharide and Gram-positive bacteria induced cytokine and chemokine production in macrophages by Galpha(i) proteins.

GNAI1 GNAI3

6.57e-06352217484771
Pubmed

Lysophosphatidic acid-operated K+ channels.

KCNK10 KCNK2

6.57e-06352215572365
Pubmed

Tension activation of mechanosensitive two-pore domain K+ channels TRAAK, TREK-1, and TREK-2.

KCNK10 KCNK2

6.57e-06352238605031
Pubmed

Dysfunction of KCNK potassium channels impairs neuronal migration in the developing mouse cerebral cortex.

KCNK10 KCNK2

6.57e-06352223236211
Pubmed

PAX immunoreactivity in poorly differentiated small round cell tumors of childhood.

PAX2 PAX5

6.57e-06352224897005
Pubmed

Behavioral characterization of mice lacking Trek channels.

KCNK10 KCNK2

6.57e-06352222973213
Pubmed

The cancer stem cell marker CD133 interacts with plakoglobin and controls desmoglein-2 protein levels.

PROM1 DSG2

6.57e-06352223326490
Pubmed

Differential effects of inhibitory G protein isoforms on G protein-gated inwardly rectifying K+ currents in adult murine atria.

GNAI1 GNAI3

6.57e-06352229342363
Pubmed

Pax-5 is expressed at the midbrain-hindbrain boundary during mouse development.

PAX2 PAX5

6.57e-0635221283313
Pubmed

Mixing and matching TREK/TRAAK subunits generate heterodimeric K2P channels with unique properties.

KCNK10 KCNK2

6.57e-06352227035965
Pubmed

Identification and expression of G-proteins in human myometrium: up-regulation of G alpha s in pregnancy.

GNAI1 GNAI3

6.57e-0635228504751
Pubmed

GNAI1 and GNAI3 Reduce Colitis-Associated Tumorigenesis in Mice by Blocking IL6 Signaling and Down-regulating Expression of GNAI2.

GNAI1 GNAI3

6.57e-06352230836096
Pubmed

Antidepression action of BDNF requires and is mimicked by Gαi1/3 expression in the hippocampus.

GNAI1 GNAI3

6.57e-06352229507199
Pubmed

Gαi1 and Gαi3mediate VEGF-induced VEGFR2 endocytosis, signaling and angiogenesis.

GNAI1 GNAI3

6.57e-06352230279732
Pubmed

Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development.

DCHS2 PAX2 PAX5

8.00e-062652321303848
Pubmed

Most central nervous system D2 dopamine receptors are coupled to their effectors by Go.

GNAI1 GNAI3

1.31e-05452211248120
Pubmed

Gαi1/3 mediate Netrin-1-CD146-activated signaling and angiogenesis.

GNAI1 GNAI3

1.31e-05452237153740
Pubmed

Id helix-loop-helix proteins antagonize pax transcription factor activity by inhibiting DNA binding.

PAX2 PAX5

1.31e-05452211134340
Pubmed

Elevated expression of TREK-TRAAK K2P channels in the retina of adult rd1 mice.

KCNK10 KCNK2

1.31e-05452231236347
Pubmed

RGS10 is a selective activator of G alpha i GTPase activity.

GNAI1 GNAI3

1.31e-0545228774883
Pubmed

Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division.

GNAI1 GNAI3

1.31e-05452217635935
Pubmed

Mouse gene knockout and knockin strategies in application to alpha subunits of Gi/Go family of G proteins.

GNAI1 GNAI3

1.31e-05452211771389
Pubmed

Gαi1 and Gαi3 regulate macrophage polarization by forming a complex containing CD14 and Gab1.

GNAI1 GNAI3

1.31e-05452225825741
Pubmed

CB1 receptor-G protein association. Subtype selectivity is determined by distinct intracellular domains.

GNAI1 GNAI3

1.31e-05452211168387
Pubmed

Functional equivalence of the transcription factors Pax2 and Pax5 in mouse development.

PAX2 PAX5

1.31e-05452210934015
Pubmed

Regulator of G protein signaling Z1 (RGSZ1) interacts with Galpha i subunits and regulates Galpha i-mediated cell signaling.

GNAI1 GNAI3

1.31e-05452212379657
Pubmed

Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells.

GNAI1 GNAI3

1.31e-0545221902575
Pubmed

The role of inhibitory heterotrimeric G proteins in the control of in vivo heart rate dynamics.

GNAI1 GNAI3

1.31e-05452218832081
Pubmed

Analysis of RGSZ1 protein interaction with Galphai subunits.

GNAI1 GNAI3

1.31e-05452215488169
Pubmed

Two Pax-binding sites are required for early embryonic brain expression of an Engrailed-2 transgene.

PAX2 PAX5

1.31e-0545228625814
Pubmed

Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP.

GNAI1 GNAI3

1.31e-05452210364213
Pubmed

Specific interaction of Gαi3 with the Oa1 G-protein coupled receptor controls the size and density of melanosomes in retinal pigment epithelium.

GNAI1 GNAI3

1.31e-05452221931697
Pubmed

Coupling of Airway Smooth Muscle Bitter Taste Receptors to Intracellular Signaling and Relaxation Is via Gαi1,2,3.

GNAI1 GNAI3

1.31e-05452228145731
Pubmed

GIV/Girdin activates Gαi and inhibits Gαs via the same motif.

GNAI1 GNAI3

1.31e-05452227621449
Pubmed

Essential roles for the splicing regulator nSR100/SRRM4 during nervous system development.

ARVCF VPS13C REST

1.38e-053152325838543
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

ZC3H11A NCAPG DSG2 AHCTF1 ATG2B ELP4 TP53BP1

1.70e-0554952738280479
Pubmed

K(+) efflux through two-pore domain K(+) channels is required for mouse embryonic development.

KCNK10 KCNK2

2.19e-05552222419831
Pubmed

Oxidized human neuroglobin acts as a heterotrimeric Galpha protein guanine nucleotide dissociation inhibitor.

GNAI1 GNAI3

2.19e-05552212860983
Pubmed

Piezo1 and Piezo2 foster mechanical gating of K2P channels.

KCNK10 KCNK2

2.19e-05552234852225
Pubmed

Mechanoprotection by polycystins against apoptosis is mediated through the opening of stretch-activated K(2P) channels.

KCNK10 KCNK2

2.19e-05552222832196
Pubmed

miR-1915 and miR-1225-5p regulate the expression of CD133, PAX2 and TLR2 in adult renal progenitor cells.

PROM1 PAX2

2.19e-05552223861881
Pubmed

Coupling of dopamine receptor subtypes to multiple and diverse G proteins.

GNAI1 GNAI3

2.19e-05552210978845
Pubmed

An essential role for Gα(i2) in Smoothened-stimulated epithelial cell proliferation in the mammary gland.

GNAI1 GNAI3

2.19e-05552226373672
Pubmed

Macrophage autophagy in immunity to Cryptococcus neoformans and Candida albicans.

ATG2B ATG2A

2.19e-05552222710871
Pubmed

G-protein alpha subunit interaction and guanine nucleotide dissociation inhibitor activity of the dual GoLoco motif protein PCP-2 (Purkinje cell protein-2).

GNAI1 GNAI3

2.19e-05552216298104
Pubmed

Defective macrophage migration in Gαi2- but not Gαi3-deficient mice.

GNAI1 GNAI3

2.19e-05552222706085
Pubmed

Molecular cloning of five GTP-binding protein cDNA species from rat olfactory neuroepithelium.

GNAI1 GNAI3

2.19e-0555222820999
Pubmed

Glucose inhibition persists in hypothalamic neurons lacking tandem-pore K+ channels.

KCNK10 KCNK2

2.19e-05552219244527
Pubmed

GINIP, a Gαi-interacting protein, functions as a key modulator of peripheral GABAB receptor-mediated analgesia.

GNAI1 GNAI3

2.19e-05552225242222
Pubmed

Pax-2 expression in the murine neural plate precedes and encompasses the expression domains of Wnt-1 and En-1.

PAX2 PAX5

2.19e-0555227577673
Pubmed

Estrogen- and xenoestrogen-induced ERK signaling in pituitary tumor cells involves estrogen receptor-α interactions with G protein-αi and caveolin I.

GNAI1 GNAI3

2.19e-05552222230296
Pubmed

RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity.

GNAI1 GNAI3

2.19e-05552211387333
Pubmed

HIV-1 triggers WAVE2 phosphorylation in primary CD4 T cells and macrophages, mediating Arp2/3-dependent nuclear migration.

GNAI1 GNAI3

2.19e-05552224415754
Pubmed

Requirement of Gαi1/3-Gab1 signaling complex for keratinocyte growth factor-induced PI3K-AKT-mTORC1 activation.

GNAI1 GNAI3

3.28e-05652225078664
Pubmed

Identification of the platelet ADP receptor targeted by antithrombotic drugs.

GNAI1 GNAI3

3.28e-05652211196645
Pubmed

Gialpha and Gbeta subunits both define selectivity of G protein activation by alpha2-adrenergic receptors.

GNAI1 GNAI3

3.28e-05652216371464
Pubmed

Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.

GNAI1 GNAI3

3.28e-05652218434541
Pubmed

A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse.

PAX5 TP53BP1

3.28e-05652218676810
Pubmed

Development of the mammalian axial skeleton requires signaling through the Gα(i) subfamily of heterotrimeric G proteins.

GNAI1 GNAI3

3.28e-05652223236180
Pubmed

Roles of Pax-genes in developing and adult brain as suggested by expression patterns.

PAX2 PAX5

3.28e-0565228126546
Pubmed

Galpha(i1) and Galpha(i3) are required for epidermal growth factor-mediated activation of the Akt-mTORC1 pathway.

GNAI1 GNAI3

3.28e-05652219401591
Pubmed

Intrinsic planar polarity mechanisms influence the position-dependent regulation of synapse properties in inner hair cells.

GNAI1 GNAI3

3.28e-05652230975754
Pubmed

Insights into the release mechanism of astrocytic glutamate evoking in neurons NMDA receptor-mediated slow depolarizing inward currents.

KCNK10 KCNK2

3.28e-05652230144319
Pubmed

Ecotopic viral integration site 1 (EVI1) regulates multiple cellular processes important for cancer and is a synergistic partner for FOS protein in invasive tumors.

PAX2 PAX5

3.28e-05652222308434
Pubmed

Cloning and characterization of a novel regulator of G protein signalling in human platelets.

GNAI1 GNAI3

3.28e-05652211955952
Pubmed

Characterization of RGS5 in regulation of G protein-coupled receptor signaling.

GNAI1 GNAI3

3.28e-05652211253162
Pubmed

Mapping of the human homologs of the murine paired-box-containing genes.

PAX2 PAX5

3.28e-0565228431641
Pubmed

Pax2 contributes to inner ear patterning and optic nerve trajectory.

PAX2 PAX5

4.58e-0575228951055
Pubmed

Conserved biological function between Pax-2 and Pax-5 in midbrain and cerebellum development: evidence from targeted mutations.

PAX2 PAX5

4.58e-0575229405645
Pubmed

Kv1.1 channels act as mechanical brake in the senses of touch and pain.

KCNK10 KCNK2

4.58e-05752223473320
Pubmed

CCL3, acting via the chemokine receptor CCR5, leads to independent activation of Janus kinase 2 (JAK2) and Gi proteins.

GNAI1 GNAI3

4.58e-05752215251452
Pubmed

Activation state-dependent interaction between Galphai and p67phox.

GNAI1 GNAI3

4.58e-05752216782902
Pubmed

Cooperation of Pax2 and Pax5 in midbrain and cerebellum development.

PAX2 PAX5

4.58e-0575229159136
Pubmed

GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits.

GNAI1 GNAI3

4.58e-0575228986788
Pubmed

The mesenchymal alpha11beta1 integrin attenuates PDGF-BB-stimulated chemotaxis of embryonic fibroblasts on collagens.

ITGA11 PDGFB

4.58e-05752215183724
Pubmed

Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer.

DSG2 VPS13C EIF4A1 GNAI1 GNAI3

4.71e-0526452532814769
Pubmed

Distinct regulators control the expression of the mid-hindbrain organizer signal FGF8.

PAX2 PAX5

6.10e-05852211704761
GeneFamilyPaired boxes

PAX2 PAX5

1.38e-049362675
GeneFamilyPotassium two pore domain channel subfamily K

KCNK10 KCNK2

3.98e-0415362277
GeneFamilyAutophagy related

ATG2B ATG2A

1.96e-03333621022
GeneFamilyZinc fingers CCCH-type

ZC3H11A ZC3H11B

2.20e-033536273
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

COL6A3 ITGA11 NCAPG ANO1 PCK1

2.41e-061845254a9f798c67b9998bffe44242b210cc1e224ff5b1
ToppCelldroplet-Liver-LIVER_HEP-30m-Mesenchymal|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A3 ARVCF KCNJ8 ANO1 NCKAP5

2.47e-06185525f814ec9d4ade717a0109398e9768d0d66f09317b
ToppCelldroplet-Liver-LIVER_HEP-30m-Mesenchymal-hepatic_stellate_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A3 ARVCF KCNJ8 ANO1 NCKAP5

2.47e-0618552540e958511790e84321da5ccf735f9974c06a0263
ToppCelldroplet-Liver-LIVER_HEP-30m-Mesenchymal-hepatic_stellate_cell|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A3 ARVCF KCNJ8 ANO1 NCKAP5

2.47e-061855255f2eeba80aff145e85cfd81e2890a155406badb9
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-Pericytes-angiogenic_pericyte|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL6A3 ITGA11 KCNJ8 ANO1 GNAI1

2.68e-061885250a5b93c131ce8514e996b0c2f39e0fc98636c122
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

PROM1 COL6A3 SLC8A3 DOCK10 GNAI1

3.20e-061955250e55fa5b3cbeb7baee3d4ac272a3bf80381ec937
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-Pericytes-angiogenic_pericyte|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL6A3 ITGA11 KCNJ8 ANO1 GNAI1

3.53e-061995259e32644b93fb1c4946dbe388fd5c357304d14e36
ToppCellPBMC-Mild-cDC_2|Mild / Compartment, Disease Groups and Clusters

FREM2 ZC3H11A KCNK10 DNAH9

1.88e-05135524cb9d834f8301cf53f20e09c3f4cb6a148690196a
ToppCellThalamus-Macroglia-POLYDENDROCYTE-P1|Thalamus / BrainAtlas - Mouse McCarroll V32

PROM1 PDGFB EIF4A1 NCKAP5

2.62e-05147524a21b63d0d3aec9ffadf3fac833a0a24da58a95bf
ToppCell3'_v3-bone_marrow-Hematopoietic_progenitors-Progenitor|bone_marrow / Manually curated celltypes from each tissue

PROM1 SLC8A3 DSG2 GNAI1

2.76e-05149524078e1e5765e476ba85c23fb8f6892b6698cbcbdb
ToppCellfacs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

FREM2 PDGFB DNAH9 UNC80

3.83e-05162524bf886e22ff2a20353499004b53f25fb9e6574896
ToppCellPND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_G2M|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

NCAPG KCNK10 PAX5 MAD2L1

4.02e-05164524249d8f75a64bce7db52ce0c563f496b9edf602a6
ToppCell10x_3'_v3-blood_(10x_3'_v3)-hematologic-hematopoietic_progenitor-hematopoietic_stem_cell|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PROM1 SLC8A3 DSG2 GNAI1

4.62e-051705245bb577e2c4bd275fbe4ee23ff8c007b2fcb90e56
ToppCell10x_3'_v3-blood_(10x_3'_v3)-hematologic-hematopoietic_progenitor|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PROM1 SLC8A3 DSG2 GNAI1

5.06e-0517452466df78280f657978c4a568010ae7d7943869af90
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Adenocarcinoma_Mixed_Subtype-4|TCGA-Lung / Sample_Type by Project: Shred V9

ITGA11 DOCK10 ELK3 DDX60L

5.29e-051765240923b01137d6f9956ca815b41102c81e82624065
ToppCellcontrol-Others-CD34+_GATA2+_cells|control / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

PROM1 SLC8A3 DSG2 GNAI1

5.53e-051785242120bd3e099b0b271bf079db9827a2f3eee2f909
ToppCellCOVID-19-kidney-PCT-S1/S2|COVID-19 / Disease (COVID-19 only), tissue and cell type

FREM2 NCKAP5 PAX2 PCK1

5.53e-0517852423a12d3d971b857d5be8e907334d1f6b49eeeb32
ToppCellsevere-Others-CD34+_GATA2+_cells|severe / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

PROM1 SLC8A3 DSG2 GNAI1

5.65e-05179524dd789a1b7327d6f9ed5272f3eb54bd43f7ae8d78
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FREM2 DCHS2 ITGA11 ELK3

5.90e-0518152413270b6ba6a9c8e5681c6f40000c643ce1d9344a
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_IT_L5/L6_Car3_THEMIS-Exc_L5-6_THEMIS_IL7R|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FREM2 DCHS2 ITGA11 ELK3

5.90e-051815243e3c903b522dced6bec5dc447cc3f8bf9a9749e3
ToppCellPBMC-Control-Hematopoietic-HSPC-HSPC-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

PROM1 SLC8A3 DSG2 GNAI1

6.03e-051825246497eeafb2b137e70261ec0314782831892a940d
ToppCellPBMC-Control-Hematopoietic-HSPC-HSPC|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PROM1 SLC8A3 DSG2 GNAI1

6.03e-05182524d0ebf2f0d5370458ab81485a0017c311077133d5
ToppCellPBMC-Control-Hematopoietic-HSPC|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

PROM1 SLC8A3 DSG2 GNAI1

6.03e-05182524bd1626261803324084fafca2f6665b50854e7fae
ToppCelldroplet-Heart-4Chambers-18m-Neuronal-cardiac_neuron|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARVCF KCNK2 GNAI1 UNC80

6.03e-051825246fdaf3c8c3952a8f14dd7288e523ed58eb1d3517
ToppCellPBMC-Control-Hematopoietic-HSPC-HSPC-|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PROM1 SLC8A3 DSG2 GNAI1

6.03e-051825242a6d1246bfb5899a0861c7f2f8fb9b43b0df8acc
ToppCellPBMC-Control-Hematopoietic-HSPC|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

PROM1 SLC8A3 DSG2 GNAI1

6.03e-05182524918286422b3eab32d962b49aa07b1b9512e51d9d
ToppCellPBMC-Control-Hematopoietic-HSPC-HSPC|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)

PROM1 SLC8A3 DSG2 GNAI1

6.03e-051825240d9b8c900da8cbae9cde72aecd4026b1ac2bbd67
ToppCelldroplet-Limb_Muscle-Pre-Sort-18m-Macroglial-nan|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC8A3 KCNK10 GNAI1 UNC80

6.03e-05182524c00e503f442d44fbae73c5e2dc85be69e294e67a
ToppCellE12.5-Endothelial-capillary_endothelial_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PDE8A PDGFB ADAM15 ELK3

6.42e-05185524e005d3c01a908157f780bbc1d53dd2ed814a39d2
ToppCellCV-Moderate-7|Moderate / Virus stimulation, Condition and Cluster

VPS13C AHCTF1 MCM9 DOCK10

6.42e-05185524a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCellE12.5-Endothelial-capillary_endothelial_cell-capillary_endothelial_cell|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PDE8A PDGFB ADAM15 ELK3

6.42e-051855240bccc424d0466f7f82baa00127c733640a2d50fb
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal-Stroma____fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A3 ITGA11 SLC8A3 KCNK2

6.42e-05185524785c55d39909fac74415f24427979691e7e694e6
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A3 ITGA11 SLC8A3 KCNK2

6.42e-0518552497a1dcacbc48dc3f41c26fbb59af35c935f894d4
ToppCellfacs-Heart-LA-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARVCF KCNJ8 ANO1 TEX44

6.56e-05186524e2ba9f3518d87a44537a57a648df17ab98fbbb39
ToppCellfacs-Heart-LA-18m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARVCF KCNJ8 ANO1 TEX44

6.56e-05186524fda3415222f688ef5cd8de4b0b79daa2493c585f
ToppCelldroplet-Liver-LIVER_HEP-30m-Lymphocytic-nan|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PROM1 GNAI1 UNC80 TP53BP1

6.56e-05186524f5468e03321ea2083e223eb0d92c3a9307039569
ToppCelldroplet-Kidney-KIDNEY-1m-Mesenchymal-fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A3 ITGA11 SLC8A3 KCNK2

6.56e-0518652494d577dbb6bfacf50632e1fe8af041b35a1e6b23
ToppCell3'-GW_trimst-2-LargeIntestine-Mesenchymal-Pericytes-angiogenic_pericyte|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL6A3 ITGA11 KCNJ8 GNAI1

6.56e-051865240b2ce9b8a4382d583240647217ad5e2d3fa555c1
ToppCellCV-Moderate-7|CV / Virus stimulation, Condition and Cluster

VPS13C AHCTF1 MCM9 DOCK10

6.56e-051865248571956890fc9894d766ba294a28e376b4aba428
ToppCellE12.5-Endothelial|E12.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PDE8A PDGFB ADAM15 ELK3

6.69e-05187524b8ed57b3c39ffbf750cd08a3e03ec11dae43d00e
ToppCell10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8|GI_small-bowel / Manually curated celltypes from each tissue

VPS13C AHCTF1 DOCK10 TP53BP1

6.83e-05188524ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCellLPS-antiTNF-Stromal_mesenchymal-Lung_smooth_muscle-Myofibroblast|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PROM1 FREM2 COL6A3 ANO1

6.83e-05188524293f2fa99f5f96aa7fd2b2a5cc94ff60eeaabe11
ToppCell3'_v3-lymph-node_spleen-Myeloid_Dendritic-Cycling_Dendritic|lymph-node_spleen / Manually curated celltypes from each tissue

NCAPG KCNK10 NCKAP5 TNFRSF21

6.83e-05188524723348a1836a074e068320cb736ce6a953e0038f
ToppCell10x3'2.3-week_17-19-Mesenchymal_osteo-stroma-osteochondral_precursor|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

COL6A3 KCNJ8 KCNK2 NCKAP5

6.98e-051895241ff4f8da572bdc6356e9df9f41a7f62c81d4c570
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARVCF KCNJ8 ANO1 NCKAP5

6.98e-05189524de51fbd6fdb24fc4549393cf41a020005444b2aa
ToppCelldroplet-Heart-HEART_(ALL_MINUS_AORTA)-30m-Mesenchymal-smooth_muscle_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ARVCF KCNJ8 ANO1 NCKAP5

7.12e-051905241d8e169d2448a34180c415843bb49aa45ed540c5
ToppCellfacs-Heart-RA-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNJ8 ANO1 NCKAP5 TNFRSF21

7.12e-05190524bfbdf16d488359d7935a419c4c1823288f39c183
ToppCellfacs-Heart-RA-3m-Mesenchymal-valve_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

KCNJ8 ANO1 NCKAP5 TNFRSF21

7.12e-05190524eb1f8bb4d903b08e50c2dc173b06c0c79d8e316e
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COL6A3 ITGA11 KCNK2 ANO1

7.27e-051915241caf726bd07fdca389e678fc16304a6ef1790423
ToppCellCD8+_Memory_T_cell-CV-7|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

VPS13C AHCTF1 MCM9 DOCK10

7.27e-051915249454f642c3621370fa23640b631301346b300950
ToppCellhuman_hepatoblastoma-Hepatic_Stellate_cells|human_hepatoblastoma / Sample and Cell Type and Tumor Cluster (all cells)

COL6A3 ITGA11 KCNJ8 ANO1

7.27e-0519152478c3c2fdb68c3407f2436f90e1e6a780bbf8b79e
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Collagen-low_Matrisome-low_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COL6A3 ITGA11 KCNK2 ANO1

7.27e-051915243d60c46bced2984c27a1fcf2910bc38b31fb0148
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COL6A3 ITGA11 KCNK2 ANO1

7.41e-051925244022f208eb5db760abd0aac782a25e8ab63efc64
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COL6A3 ITGA11 KCNK2 ANO1

7.41e-051925249333aba0d04203ccccad78d82bf6359922f810a7
ToppCell5'-GW_trimst-2-LargeIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL6A3 DCHS2 KCNJ8 TNFRSF21

7.41e-0519252420ede290e01ad574afd122d72b59dbc52c595fad
ToppCell10x_3'_v3-bone_marrow_(10x_3'_v3)-hematologic-hematopoietic_progenitor-hematopoietic_stem_cell|bone_marrow_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PROM1 SLC8A3 DSG2 GNAI1

7.41e-0519252461677831b096b36f6325e9cb047483dd72aa71c2
ToppCell3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL6A3 DCHS2 KCNJ8 TNFRSF21

7.56e-051935247cd9671e0ac64f7f3607f564485c63abbb7e7a63
ToppCelldroplet-Bladder-BLADDER-1m-Endothelial|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PROM1 FREM2 PDGFB KCNJ8

7.56e-051935243a5090f81f35026f435f4a250d1e77601a53af15
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COL6A3 ITGA11 KCNJ8 ANO1

7.56e-05193524dc8e62df6121ee99b156aca6b1b3ae555739b6f2
ToppCelldroplet-Bladder-BLADDER-1m-Endothelial-endothelial_cell|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PROM1 FREM2 PDGFB KCNJ8

7.56e-0519352413731b7fc1e3bec0cebc44bad7e2ecea358bb76a
ToppCelldroplet-Bladder-BLADDER-1m-Endothelial-endothelial_cell|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

PROM1 FREM2 PDGFB KCNJ8

7.56e-0519352488cd7d0d0da5c776b49fc131f746fe5ad9676fb7
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-Degenerative_Fibroblast-Degenerative_Fibroblast_119|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COL6A3 ITGA11 KCNJ8 ANO1

7.56e-05193524e2ee077fd381bd906e6b4329f22e7d106e422a7f
ToppCellNS-critical-d_07-13-Epithelial-Secretory|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

FREM2 DSG2 ADAM15 GNAI1

7.72e-051945242172d951896265243d14996eacce5aab5e14e26e
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

COL6A3 SLC8A3 DOCK10 GNAI1

7.72e-05194524b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COL6A3 ITGA11 KCNJ8 KCNK2

7.72e-05194524240d122dcb9dd1ab2867503ad85869853adcacae
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

COL6A3 ITGA11 KCNJ8 KCNK2

7.72e-05194524ae7df037592f1c20c9d32be15fe6fc3c562ebeb1
ToppCellIPF-Stromal-Pericyte|World / Disease state, Lineage and Cell class

COL6A3 KCNJ8 ANO1 NCKAP5

7.72e-051945241a41da29d5adaf766a84eff0003b959e4523f7f1
ToppCell3'_v3-Lung-Myeloid_Dendritic|Lung / Manually curated celltypes from each tissue

PDGFB DSG2 KCNK10 NCKAP5

7.87e-05195524b748cb15846345363e8c2ee5936bb42bba3ba9a7
ToppCelldroplet-Bladder-nan-3m-Epithelial-bladder_mesenchymal_cell_(Car3+)|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

COL6A3 ITGA11 KCNK2 GNAI1

7.87e-05195524095b8e0be385b6390420589124a95fa4ba3682ab
ToppCellwk_15-18-Endothelial-Blood_vessel_endothelial-Late_cap|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

PDGFB ADAM15 NCKAP5 ELK3

7.87e-05195524dfc5da514fb34a2c318a5c4c61f44049fa43960e
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

COL6A3 ITGA11 KCNK2 ANO1

8.03e-05196524a12dd986df65c36f248cf10815c3b8b6238613b0
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

COL6A3 ITGA11 KCNK2 ANO1

8.03e-051965243e6803587d8566fd08cb8b290be3b6461743d79c
ToppCellIPF-Stromal-Pericyte|IPF / Disease state, Lineage and Cell class

COL6A3 KCNJ8 ANO1 NCKAP5

8.03e-051965248b6ff47ce5291d223f5e639fc45cd9267f418256
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

COL6A3 ITGA11 KCNK2 ANO1

8.19e-051975246d027119a5f7ca2aac1b10837e43f9a2bb54db85
ToppCellkidney_cells-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

COL6A3 ITGA11 KCNJ8 ANO1

8.19e-051975244cf4e9553397cd8dee883dbec24f41bec41aff99
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Pericyte-F|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

ITGA11 PDE8A KCNJ8 ANO1

8.19e-051975242872a78b1be61aa1d50bc9a49294a21e922dc033
ToppCellTCGA-Skin-Metastatic-Melanoma|TCGA-Skin / Sample_Type by Project: Shred V9

VPS13C KCNJ8 C3AR1 TBC1D9

8.35e-05198524af4fb9eb2295c7b90624b38ba25619aa15254efa
ToppCellTCGA-Skin-Metastatic|TCGA-Skin / Sample_Type by Project: Shred V9

VPS13C KCNJ8 C3AR1 TBC1D9

8.35e-05198524ad39cce004867f083f8da1954e0cf5a263815184
ToppCell5'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

COL6A3 DCHS2 KCNJ8 TNFRSF21

8.35e-0519852412cd9f0bbad8dce5199ebfed1c4a8080710ca055
ToppCellcritical-Epithelial-FOXN4+|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls

DSG2 ADAM15 GNAI1 MAD2L1

8.35e-051985246b160b3d6a2c1b1641c2c7dcec1a7ef38411fec9
ToppCellParenchymal-NucSeq-Immune_Myeloid-Macrophage_other-Macro_AW_CX3CR1|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NCAPG DOCK10 C3AR1 MAD2L1

8.35e-05198524732a43061d75bc5e1cf23f5056b72cd10c926668
ToppCellTCGA-Skin-Metastatic-Melanoma-Skin_Cutaneous_Melanoma|TCGA-Skin / Sample_Type by Project: Shred V9

VPS13C KCNJ8 C3AR1 TBC1D9

8.35e-0519852462cbf4b29e8af4983fb47a17f96da62682a5137e
ToppCellControl-Control-Others-HSPC|Control / Disease, condition lineage and cell class

PROM1 SLC8A3 DSG2 GNAI1

8.51e-05199524b71169be0d916b2ed139a3122d78bb154c71edb4
ToppCellSevere-B_intermediate-6|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)

ADAM15 DOCK10 PAX5 TBC1D9

8.51e-05199524bf6ebb63ab361d9d1946225894d7be433e9befab
ToppCelldistal-mesenchymal-Pericyte-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

COL6A3 KCNJ8 GNAI1 TNFRSF21

8.51e-05199524000d9b5f5a48e56f0733390adb3d7270c49a4a1a
ToppCelldistal-3-mesenchymal-Pericyte|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

COL6A3 KCNJ8 GNAI1 TNFRSF21

8.68e-05200524911db29f254bb697610e720ba78816e2c7f57933
ToppCellSigmoid-Dendritic_cell-cycling_DCs|Dendritic_cell / Region, Cell class and subclass

NCAPG C3AR1 TNFRSF21 MAD2L1

8.68e-05200524372fe9018481a4e9ac6ab3af43705a48238c4376
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW26-Neuroepithelial|GW26 / Sample Type, Dataset, Time_group, and Cell type.

COL6A3 ITGA11 KCNJ8 ANO1

8.68e-052005248b80811a0ec28d1d763c10b095d1969bccbe82d4
ToppCellLPS_anti-TNF-Endothelial-Endothelial-Gen_Cap|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type

PDGFB ADAM15 NCKAP5 ELK3

8.68e-05200524a2b9d1cd291d17abddc3ee2e242121412c864b8b
ToppCellFetal_brain-organoid_Tanaka_cellReport-GW26-Neuroepithelial-Proteoglycan-expressing_cell|GW26 / Sample Type, Dataset, Time_group, and Cell type.

COL6A3 ITGA11 KCNJ8 ANO1

8.68e-0520052452ec80f3922ae6ee3565d5993c2fc56bb3a3199a
ToppCellEntopeduncular-Endothelial-MURAL-M1(Rgs5Acta2)-M1_3|Entopeduncular / BrainAtlas - Mouse McCarroll V32

ANO1 C3AR1 PAX2

3.20e-04114523108cc5b04cc7c59310eb55dc2c44ae2b8e0b05e4
ToppCelldroplet-Lung-18m-Hematologic-myeloid-non-classical_monocyte-nonclassical_monocyte_l14|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

PDE8A ATG2B TNFRSF21

3.37e-04116523f2bf9599040f43b5ea8724841d7b71c0a859c016
ToppCellMild/Remission-B_naive-1|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

ZC3H11A KCNJ8 PAX5

3.81e-0412152368940a552233d255b90ce5a081339c0d9d46ab02
ToppCellSevere-B_intermediate-1|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)

ZC3H11A PAX5 TBC1D9

4.29e-0412652342a0bdbe18ef85146cac4e86b2b27d0b3b20d8a2
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligodendroglioma-2|TCGA-Brain / Sample_Type by Project: Shred V9

SLC8A3 PAX5 UNC80

4.39e-04127523018ffd9ff1913787cb0086a8581b399a121eaba1
ToppCellE18.5-samps-Mesenchymal-Matrix_fibroblast-matrix_-_immature_4|E18.5-samps / Age Group, Lineage, Cell class and subclass

DHX35 PAX2 MAD2L1

4.70e-04130523169d88bffd7cd813a484d809defa638ceaca4bcb
ToppCellStriatum-Macroglia-POLYDENDROCYTE-P1-P1_1-Tnr-Polydendrocye.Tnr.Ctps_(Ctps)|Striatum / BrainAtlas - Mouse McCarroll V32

PROM1 PDGFB NCKAP5

5.13e-04134523bc550d3b44f1e1e1c18971c110e816bcffd79d14
ToppCellStriatum-Macroglia-POLYDENDROCYTE-P1-P1_1-Tnr|Striatum / BrainAtlas - Mouse McCarroll V32

PROM1 PDGFB NCKAP5

5.13e-0413452390a34ae53a602a92f6f998e7cf061d8f4f0da527
ToppCellPBMC-Severe-Lymphocyte-B-B_cell-B_intermediate-B_intermediate-1|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

ZC3H11A PAX5 TBC1D9

5.24e-041355237743a01dc9c4542e910e7c0fe046004692a680bf
ToppCell10x_3'_v3-blood_(10x_3'_v3)-hematologic-hematopoietic_progenitor-common_myeloid_progenitor|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

PROM1 SLC8A3 DSG2

5.47e-041375236d90da42dcc06aa895f920218055068f3c76d57d
Diseasecortical surface area measurement

DCHS2 ITGA11 MTMR11 PDE8A ADAM15 KCNK10 KCNK2 DOCK10 NCKAP5 PAX2 ELK3 REST

2.91e-0613455212EFO_0010736
DiseaseFEV/FEC ratio

FREM2 COL6A3 DCHS2 MTMR11 PDGFB ARVCF VPS13C ANO1 ZC3H11B PAX2 REST

7.79e-0612285211EFO_0004713
DiseaseMcCune Albright syndrome (implicated_via_orthology)

GNAI1 GNAI3

8.47e-058522DOID:1858 (implicated_via_orthology)
DiseaseAmnesia

GNAI1 GNAI3

4.07e-0417522C0002622
DiseaseTactile Amnesia

GNAI1 GNAI3

4.07e-0417522C0750906
DiseaseAmnestic State

GNAI1 GNAI3

4.07e-0417522C0750907
DiseaseDissociative Amnesia

GNAI1 GNAI3

4.07e-0417522C0236795
DiseaseGlobal Amnesia

GNAI1 GNAI3

4.07e-0417522C0262497
DiseaseHysterical amnesia

GNAI1 GNAI3

4.07e-0417522C0233750
DiseaseTemporary Amnesia

GNAI1 GNAI3

4.07e-0417522C0233796
DiseaseAlzheimer disease, APOE carrier status

COL6A3 ANO1 ATG2A

6.98e-0498523EFO_0007659, MONDO_0004975
Diseasebrain ischemia (biomarker_via_orthology)

SLC8A3 KCNK10 KCNK2

7.84e-04102523DOID:2316 (biomarker_via_orthology)
Diseaseintelligence, response to cranial radiation therapy

DCHS2 MAD2L1

1.12e-0328522EFO_0004337, EFO_0010950
DiseaseBilateral Wilms Tumor

COL6A3 REST

1.20e-0329522C2930471
Diseaseperivascular space measurement

PDE8A KCNK2

1.28e-0330522EFO_0803382
Diseaseheart conduction disease (implicated_via_orthology)

KCNK10 KCNK2

1.46e-0332522DOID:10273 (implicated_via_orthology)
Diseasemicrocephaly (implicated_via_orthology)

ODF2 MAD2L1

1.46e-0332522DOID:10907 (implicated_via_orthology)
DiseaseHeart Failure, Diastolic

SIPA1L1 ELK3

1.55e-0333522C1135196

Protein segments in the cluster

PeptideGeneStartEntry
VTTAVIIRDKSVRNV

BTN2A3P

201

Q96KV6
KTVKTVTTRTVRQVP

ARVCF

126

O00192
RDVVTETKTVELVIV

ADAM15

206

Q13444
SQSKTFRVAVVVVAV

C3AR1

371

Q16581
FAQTIETVLRRIKVT

ATG2A

156

Q2TAZ0
TIETVLRRVKVTFID

ATG2B

156

Q96BY7
ARIESKTVIVTQEQR

PCK1

86

P35558
QQDVLRTRVKTTGIV

GNAI1

171

P63096
SVSSINRIIRTKVQQ

PAX5

131

Q02548
KVTQEIVTERSVSSR

DSG2

901

Q14126
IQVTTRTRKSVTEVK

REST

486

Q13127
ISASVRIQVVKKTTT

KCNJ8

221

Q15842
DEIRSVIRQITATVT

MAD2L1

126

Q13257
QQDVLRTRVKTTGIV

GNAI3

171

P08754
SVLVTSRVRSVILQE

MTMR11

361

A4FU01
VIRQGDTSKVSIVRV

FREM2

2276

Q5SZK8
VSQTKIRIISTIIFI

KCNK2

216

O95069
LESISTKVIVTQTTR

DDX60L

531

Q5H9U9
TITQAVIFINTRRKV

EIF4A1

271

P60842
AKTPQTRVTIRTVRV

PDGFB

201

P01127
TRVKNRVTVVITTDI

MTTP

776

P55157
KLSENTVIVGVVRRV

PDE8A

151

O60658
VSQTKIRVISTILFI

KCNK10

226

P57789
VRSNIRVTVTATAVI

ANO1

556

Q5XXA6
TTVFIIESTRQRVAV

ITGA11

826

Q9UKX5
SVSSINRIIRTKVQQ

PAX2

131

Q02962
VSAIRQVITTRKQAV

PTOV1

226

Q86YD1
RLSNTTVIKVQVTDI

DCHS2

2326

Q6V1P9
VQVRKVVALVTSVLT

OR6V1

266

Q8N148
ITTTVTRVLTDIVAK

DOCK10

921

Q96BY6
VSRSVRKVIVATNVA

DHX35

331

Q9H5Z1
TVQQVISERVTQLTR

COL6A3

1196

P12111
VEEVRTVIRFVTNKT

ELK3

176

P41970
KQVVTGTVLTRSVFI

AHCTF1

1041

Q8WYP5
RISVEVLSVVAVQVK

DNAH9

1926

Q9NYC9
KAIIARVTTLSDVVV

ELP4

311

Q96EB1
DTVNVRRSVRVKTKV

ODF2

51

Q5BJF6
VTGTVIRTSLVKVLE

MCM9

126

Q9NXL9
VLVVIVVCSIRKSSR

TNFRSF21

361

O75509
RVVKRTSSEECVTVI

NCKAP5

656

O14513
VQRQTTTVVAGIKRV

PROM1

371

O43490
IDLLRTSVTVKVVII

SIPA1L1

1011

O43166
NKRTQIVTEIISEIR

NCAPG

456

Q9BPX3
TITRVLETVEQRTVE

TEX44

356

Q53QW1
TVKEVRSQISTITVA

UNC80

561

Q8N2C7
NVRTVVRTVTLSTKQ

ZC3H11A

256

O75152
DTTKRNVVRTIVTET

TBC1D9

806

Q6ZT07
TQSVQETVRVRKVDV

VPS13C

1896

Q709C8
RTIREVRTLVTRVIT

TP53BP1

1241

Q12888
NVRTVVRTVTLSTKQ

ZC3H11B

256

A0A1B0GTU1
RETTISKVSQVRDVI

WDR3

881

Q9UNX4
SIEVITSQEREVTIK

SLC8A3

101

P57103