Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctiontransmembrane transporter activity

SLC25A3 GPR89B KCNH6 ABCA3 CLCN4 SLC16A5 SLC15A1 SLC15A2 SLC6A16 SLC22A23 PIEZO1 SLC6A5 GPR89A ABCB11 GRIK4 BCL2 GRIK5 ANKH SLC7A10 TMEM63A

6.71e-0711809620GO:0022857
GeneOntologyMolecularFunctiontransporter activity

SLC25A3 GPR89B KCNH6 ABCA3 CLCN4 SLC16A5 SLC15A1 SLC15A2 SLC6A16 SLC22A23 PIEZO1 SLC6A5 GPR89A ABCB11 GRIK4 BCL2 GRIK5 ANKH SLC7A10 TMEM63A

2.63e-0612899620GO:0005215
GeneOntologyMolecularFunctionalpha1-adrenergic receptor activity

ADRA1B ADRA1A

6.84e-053962GO:0004937
GeneOntologyMolecularFunctionvoltage-gated monoatomic anion channel activity

GPR89B CLCN4 GPR89A

6.97e-0517963GO:0008308
GeneOntologyMolecularFunctionsymporter activity

SLC25A3 SLC16A5 SLC15A1 SLC15A2 SLC6A16 SLC6A5

8.64e-05150966GO:0015293
GeneOntologyMolecularFunctionsecondary active transmembrane transporter activity

SLC25A3 CLCN4 SLC16A5 SLC15A1 SLC15A2 SLC6A16 SLC6A5 ANKH

9.10e-05296968GO:0015291
GeneOntologyMolecularFunctionactive transmembrane transporter activity

SLC25A3 ABCA3 CLCN4 SLC16A5 SLC15A1 SLC15A2 SLC6A16 SLC6A5 ABCB11 ANKH

9.91e-054779610GO:0022804
GeneOntologyMolecularFunction5'-3' RNA exonuclease activity

XRN2 XRN1

1.36e-044962GO:0004534
GeneOntologyMolecularFunctionpeptide:proton symporter activity

SLC15A1 SLC15A2

1.36e-044962GO:0015333
GeneOntologyMolecularFunctiongated channel activity

GPR89B KCNH6 CLCN4 PIEZO1 GPR89A GRIK4 GRIK5 TMEM63A

2.08e-04334968GO:0022836
GeneOntologyMolecularFunctiondipeptide transmembrane transporter activity

SLC15A1 SLC15A2

2.27e-045962GO:0071916
GeneOntologyMolecularFunctionsolute:proton symporter activity

SLC25A3 SLC15A1 SLC15A2

2.29e-0425963GO:0015295
GeneOntologyMolecularFunctionkainate selective glutamate receptor activity

GRIK4 GRIK5

3.39e-046962GO:0015277
GeneOntologyMolecularFunctionMAP kinase kinase kinase kinase activity

MAP4K3 MAP4K5

3.39e-046962GO:0008349
GeneOntologyMolecularFunctionalpha-adrenergic receptor activity

ADRA1B ADRA1A

3.39e-046962GO:0004936
GeneOntologyMolecularFunctionmonoatomic ion transmembrane transporter activity

SLC25A3 GPR89B KCNH6 CLCN4 SLC15A1 SLC15A2 PIEZO1 SLC6A5 GPR89A GRIK4 GRIK5 TMEM63A

4.15e-047939612GO:0015075
GeneOntologyMolecularFunctioncarboxylic acid transmembrane transporter activity

SLC16A5 SLC6A5 ABCB11 GRIK4 GRIK5 SLC7A10

4.93e-04207966GO:0046943
GeneOntologyMolecularFunctionorganic acid transmembrane transporter activity

SLC16A5 SLC6A5 ABCB11 GRIK4 GRIK5 SLC7A10

5.06e-04208966GO:0005342
GeneOntologyMolecularFunctionorganic anion transmembrane transporter activity

SLC16A5 SLC6A5 ABCB11 GRIK4 GRIK5 ANKH SLC7A10

5.34e-04293967GO:0008514
GeneOntologyMolecularFunctiontripeptide transmembrane transporter activity

SLC15A1 SLC15A2

8.06e-049962GO:0042937
GeneOntologyMolecularFunctionpeptide transmembrane transporter activity

SLC15A1 SLC15A2

8.06e-049962GO:1904680
GeneOntologyMolecularFunctionRNA exonuclease activity, producing 5'-phosphomonoesters

XRN2 XRN1 CNOT1

9.35e-0440963GO:0016896
GeneOntologyMolecularFunctionchannel activity

GPR89B KCNH6 CLCN4 PIEZO1 GPR89A GRIK4 BCL2 GRIK5 TMEM63A

9.58e-04525969GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

GPR89B KCNH6 CLCN4 PIEZO1 GPR89A GRIK4 BCL2 GRIK5 TMEM63A

9.70e-04526969GO:0022803
GeneOntologyMolecularFunctionadrenergic receptor activity

ADRA1B ADRA1A

1.00e-0310962GO:0004935
GeneOntologyMolecularFunctionG protein-coupled amine receptor activity

ADRA1B ADRA1A TAAR6

1.01e-0341963GO:0008227
GeneOntologyMolecularFunctionendopeptidase activity

FAP ADAMTS4 CAPN7 ADAM2 OVCH1 MMP16 MMP19 ADGRG6

1.10e-03430968GO:0004175
GeneOntologyMolecularFunctionRNA exonuclease activity

XRN2 XRN1 CNOT1

1.32e-0345963GO:0004532
GeneOntologyMolecularFunctionamino acid transmembrane transporter activity

SLC6A5 GRIK4 GRIK5 SLC7A10

1.65e-03105964GO:0015171
GeneOntologyMolecularFunctionmonoatomic ion channel activity

GPR89B KCNH6 CLCN4 PIEZO1 GPR89A GRIK4 GRIK5 TMEM63A

1.66e-03459968GO:0005216
GeneOntologyMolecularFunctionABC-type xenobiotic transporter activity

ABCA3 ABCB11

2.31e-0315962GO:0008559
GeneOntologyMolecularFunctionsolute:monoatomic cation symporter activity

SLC25A3 SLC15A1 SLC15A2 SLC6A5

2.61e-03119964GO:0015294
GeneOntologyMolecularFunctionoligopeptide transmembrane transporter activity

SLC15A1 SLC15A2

2.63e-0316962GO:0035673
GeneOntologyMolecularFunctionmetalloendopeptidase activity

ADAMTS4 ADAM2 MMP16 MMP19

2.69e-03120964GO:0004222
GeneOntologyMolecularFunctionglutamate-gated receptor activity

GRIK4 GRIK5

2.97e-0317962GO:0004970
GeneOntologyMolecularFunctionexonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

XRN2 XRN1 CNOT1

3.32e-0362963GO:0016796
GeneOntologyMolecularFunctionligand-gated sodium channel activity

GRIK4 GRIK5

3.33e-0318962GO:0015280
GeneOntologyMolecularFunction5'-3' exonuclease activity

XRN2 XRN1

3.33e-0318962GO:0008409
GeneOntologyMolecularFunctionmechanosensitive monoatomic ion channel activity

PIEZO1 TMEM63A

3.33e-0318962GO:0008381
GeneOntologyMolecularFunctioninorganic molecular entity transmembrane transporter activity

SLC25A3 KCNH6 CLCN4 SLC15A1 SLC15A2 SLC6A5 GRIK4 GRIK5 ANKH TMEM63A

3.49e-037589610GO:0015318
GeneOntologyMolecularFunctionRNA nuclease activity

XRN2 XRN1 PRORP CNOT1

4.22e-03136964GO:0004540
GeneOntologyMolecularFunctionpeptidase activity

FAP ADAMTS4 CAPN7 ADAM2 OVCH1 MMP16 MMP19 USP3 ADGRG6

4.23e-03654969GO:0008233
GeneOntologyMolecularFunctionmonoatomic cation transmembrane transporter activity

SLC25A3 KCNH6 SLC15A1 SLC15A2 PIEZO1 SLC6A5 GRIK4 GRIK5 TMEM63A

4.67e-03664969GO:0008324
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

KCNH6 GRIK4 GRIK5 TMEM63A

4.67e-03140964GO:0099094
GeneOntologyMolecularFunctionphosphate transmembrane transporter activity

SLC25A3 ANKH

5.89e-0324962GO:0005315
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

GRIK4 GRIK5

5.89e-0324962GO:0099507
GeneOntologyBiologicalProcesstripeptide import across plasma membrane

SLC15A1 SLC15A2

2.10e-052952GO:0140207
GeneOntologyBiologicalProcessmonoatomic ion transmembrane transport

SLC25A3 GPR89B KCNH6 ADRA1A CLCN4 SLC15A1 SLC15A2 SLC6A16 PIEZO1 SLC6A5 GPR89A STEAP4 GRIK4 BCL2 GRIK5 TMEM63A

4.66e-0511159516GO:0034220
GeneOntologyBiologicalProcesspositive regulation of heart rate by epinephrine-norepinephrine

ADRA1B ADRA1A

1.25e-044952GO:0001996
GeneOntologyBiologicalProcesspositive regulation of the force of heart contraction by epinephrine-norepinephrine

ADRA1B ADRA1A

1.25e-044952GO:0001997
GeneOntologyBiologicalProcessDNA repair-dependent chromatin remodeling

USP3 TRIP12 HDGFL2

1.57e-0423953GO:0140861
GeneOntologyBiologicalProcessmonoatomic ion transport

SLC25A3 GPR89B KCNH6 ADRA1A CLCN4 SLC15A1 SLC15A2 SLC6A16 SLC22A23 PIEZO1 SLC6A5 GPR89A STEAP4 GRIK4 BCL2 GRIK5 TMEM63A

1.63e-0413749517GO:0006811
GeneOntologyBiologicalProcessneuron-glial cell signaling

ADRA1B ADRA1A

2.08e-045952GO:0150099
GeneOntologyBiologicalProcessoligopeptide import across plasma membrane

SLC15A1 SLC15A2

2.08e-045952GO:0140205
GeneOntologyBiologicalProcessdipeptide import across plasma membrane

SLC15A1 SLC15A2

2.08e-045952GO:0140206
GeneOntologyBiologicalProcesssynaptic transmission, glycinergic

SLC6A5 SLC7A10

2.08e-045952GO:0060012
GeneOntologyBiologicalProcesspositive regulation of the force of heart contraction by chemical signal

ADRA1B ADRA1A

2.08e-045952GO:0003099
GeneOntologyCellularComponentGolgi membrane

ACER2 GPR89B NAPEPLD OTOF SURF4 DHCR24 ARFGEF2 GPR89A ABCB11 STEAP4 PGAP4 HEPACAM2 GOLT1A RIC1 DOP1B

9.83e-077219615GO:0000139
GeneOntologyCellularComponentpresynaptic membrane

ADRA1A NAPEPLD OTOF SLC6A5 GRIK4 GRIK5 RIMS1

2.90e-04277967GO:0042734
GeneOntologyCellularComponentkainate selective glutamate receptor complex

GRIK4 GRIK5

3.09e-046962GO:0032983
GeneOntologyCellularComponentearly endosome membrane

CLCN4 NAPEPLD NTRK1 STEAP4 DOP1B TMEM63A

4.40e-04212966GO:0031901
DomainPut_53exo

XRN2 XRN1

2.51e-052942IPR004859
DomainLEDGF

PSIP1 HDGFL2

2.51e-052942PF11467
DomainLEDGF

PSIP1 HDGFL2

2.51e-052942IPR021567
Domain5_3_exoribonuclease

XRN2 XRN1

2.51e-052942IPR027073
DomainOligopep_transport

SLC15A1 SLC15A2

2.51e-052942IPR004768
DomainXRN_N

XRN2 XRN1

2.51e-052942PF03159
DomainCK1gamma_C

CSNK1G2 CSNK1G1

7.49e-053942PF12605
DomainCasein_kinase-1_gamma_C

CSNK1G2 CSNK1G1

7.49e-053942IPR022247
DomainPTR2_symporter_CS

SLC15A1 SLC15A2

7.49e-053942IPR018456
DomainPTR2_1

SLC15A1 SLC15A2

7.49e-053942PS01022
DomainPWWP

PSIP1 HDGFL2 HDGF

1.32e-0420943SM00293
DomainMAPKKKK

MAP4K3 MAP4K5

1.49e-044942IPR021160
DomainPTR2_2

SLC15A1 SLC15A2

1.49e-044942PS01023
DomainPWWP

PSIP1 HDGFL2 HDGF

2.03e-0423943PF00855
DomainPWWP_dom

PSIP1 HDGFL2 HDGF

2.03e-0423943IPR000313
DomainPWWP

PSIP1 HDGFL2 HDGF

2.31e-0424943PS50812
DomainPOT_fam

SLC15A1 SLC15A2

2.48e-045942IPR000109
DomainPTR2

SLC15A1 SLC15A2

2.48e-045942PF00854
DomainCarboxylesterase_B_AS

CEL CES4A

6.88e-048942IPR019826
DomainCARBOXYLESTERASE_B_1

CEL CES4A

6.88e-048942PS00122
DomainMetalloPept_cat_dom

ADAMTS4 ADAM2 MMP16 MMP19

7.44e-0481944IPR024079
Domain-

ADAMTS4 ADAM2 MMP16 MMP19

7.44e-04819443.40.390.10
DomainADR_fam

ADRA1B ADRA1A

1.10e-0310942IPR002233
DomainCarboxylesterase_B_CS

CEL CES4A

1.89e-0313942IPR019819
DomainCARBOXYLESTERASE_B_2

CEL CES4A

2.19e-0314942PS00941
DomainCOesterase

CEL CES4A

2.19e-0314942PF00135
DomainCarbesteraseB

CEL CES4A

2.19e-0314942IPR002018
DomainCNH

MAP4K3 MAP4K5

2.19e-0314942SM00036
DomainCNH

MAP4K3 MAP4K5

2.52e-0315942PF00780
DomainCNH

MAP4K3 MAP4K5

2.52e-0315942PS50219
DomainCNH_dom

MAP4K3 MAP4K5

2.52e-0315942IPR001180
DomainIontro_rcpt

GRIK4 GRIK5

3.64e-0318942IPR001320
DomainLig_chan-Glu_bd

GRIK4 GRIK5

3.64e-0318942PF10613
DomainIono_rcpt_met

GRIK4 GRIK5

3.64e-0318942IPR001508
DomainGlu/Gly-bd

GRIK4 GRIK5

3.64e-0318942IPR019594
DomainNA_NEUROTRAN_SYMP_2

SLC6A16 SLC6A5

3.64e-0318942PS00754
DomainLig_chan-Glu_bd

GRIK4 GRIK5

3.64e-0318942SM00918
DomainPept_M10A_stromelysin-type

MMP16 MMP19

3.64e-0318942IPR016293
DomainLig_chan

GRIK4 GRIK5

3.64e-0318942PF00060
DomainPBPe

GRIK4 GRIK5

3.64e-0318942SM00079
DomainSNF

SLC6A16 SLC6A5

4.05e-0319942PF00209
DomainNA_NEUROTRAN_SYMP_1

SLC6A16 SLC6A5

4.05e-0319942PS00610
DomainNA_NEUROTRAN_SYMP_3

SLC6A16 SLC6A5

4.05e-0319942PS50267
DomainNa/ntran_symport

SLC6A16 SLC6A5

4.05e-0319942IPR000175
DomainPG_binding_1

MMP16 MMP19

4.49e-0320942PF01471
DomainPeptidoglycan-bd-like

MMP16 MMP19

4.49e-0320942IPR002477
DomainMFS_dom

SLC16A5 SLC15A1 SLC15A2 SLC22A23

4.69e-03134944IPR020846
Pubmed

Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.

INTU SLC22A23 SCARB1 TBCK ASS1 RIMS1 BAIAP2 PRORP ZSWIM1 MMP16 USP3 CNOT1 ANKH RIC1 ADGRG6 TMEM63A

3.06e-061489961628611215
Pubmed

USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.

XRN2 PSIP1 SLC15A1 OTOF MYO7B OVCH1 TRIP12

4.09e-0623496736243803
Pubmed

Biochemical and genetic analyses of integrase-interacting proteins lens epithelium-derived growth factor (LEDGF)/p75 and hepatoma-derived growth factor related protein 2 (HRP2) in preintegration complex function and HIV-1 replication.

PSIP1 HDGFL2

7.54e-06296216337983
Pubmed

ABC transporter expression profiling after ischemic reperfusion injury in mouse kidney.

ABCA3 ABCB11

7.54e-06296216612327
Pubmed

An alpha1A-adrenergic-extracellular signal-regulated kinase survival signaling pathway in cardiac myocytes.

ADRA1B ADRA1A

7.54e-06296217283256
Pubmed

Alpha1-adrenergic receptors prevent a maladaptive cardiac response to pressure overload.

ADRA1B ADRA1A

7.54e-06296216585965
Pubmed

High-affinity kainate receptor subunits are necessary for ionotropic but not metabotropic signaling.

GRIK4 GRIK5

7.54e-06296219778510
Pubmed

LEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription in differentiated cells.

PSIP1 HDGFL2

7.54e-06296231616795
Pubmed

Oligomerization of the alpha 1a- and alpha 1b-adrenergic receptor subtypes. Potential implications in receptor internalization.

ADRA1B ADRA1A

7.54e-06296212888550
Pubmed

Importance of a small N-terminal region in mammalian peptide transporters for substrate affinity and function.

SLC15A1 SLC15A2

7.54e-06296211944083
Pubmed

Comparison of human and monkey peptide transporters: PEPT1 and PEPT2.

SLC15A1 SLC15A2

7.54e-06296215981923
Pubmed

Peptide transporters and their roles in physiological processes and drug disposition.

SLC15A1 SLC15A2

7.54e-06296218668438
Pubmed

Lack of interaction between the peptidomimetic substrates captopril and cephradine.

SLC15A1 SLC15A2

7.54e-06296219246733
Pubmed

alpha(1A)- and alpha(1B)-adrenergic receptors differentially modulate antidepressant-like behavior in the mouse.

ADRA1B ADRA1A

7.54e-06296219540213
Pubmed

HRP-2 determines HIV-1 integration site selection in LEDGF/p75 depleted cells.

PSIP1 HDGFL2

7.54e-06296223046603
Pubmed

The alpha(1A/C)- and alpha(1B)-adrenergic receptors are required for physiological cardiac hypertrophy in the double-knockout mouse.

ADRA1B ADRA1A

7.54e-06296212782680
Pubmed

Subunit-specific desensitization of heteromeric kainate receptors.

GRIK4 GRIK5

7.54e-06296220026616
Pubmed

Carboxyl ester lipase cofractionates with scavenger receptor BI in hepatocyte lipid rafts and enhances selective uptake and hydrolysis of cholesteryl esters from HDL3.

CEL SCARB1

7.54e-06296215105424
Pubmed

Nuclear localization drives α1-adrenergic receptor oligomerization and signaling in cardiac myocytes.

ADRA1B ADRA1A

7.54e-06296222120526
Pubmed

Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited.

SLC15A1 SLC15A2

7.54e-06296218713951
Pubmed

Molecular mechanism of dipeptide and drug transport by the human renal H+/oligopeptide cotransporter hPEPT2.

SLC15A1 SLC15A2

7.54e-06296218367661
Pubmed

GPHR-dependent functions of the Golgi apparatus are essential for the formation of lamellar granules and the skin barrier.

GPR89B GPR89A

7.54e-06296222572823
Pubmed

Tissue distribution and thyroid hormone regulation of Pept1 and Pept2 mRNA in rodents.

SLC15A1 SLC15A2

7.54e-06296216202478
Pubmed

Genetic ablation of the GluK4 kainate receptor subunit causes anxiolytic and antidepressant-like behavior in mice.

GRIK4 GRIK5

7.54e-06296222203159
Pubmed

The bioactive dipeptide anserine is transported by human proton-coupled peptide transporters.

SLC15A1 SLC15A2

7.54e-06296220067523
Pubmed

Identification of the LEDGF/p75 HIV-1 integrase-interaction domain and NLS reveals NLS-independent chromatin tethering.

PSIP1 HDGFL2

7.54e-06296215797927
Pubmed

[Distribution and significance of α1-adrenoceptor subtypes in patients with chronic prostatitis in prostate, bladder detrusor and posterior urethral tissue].

ADRA1B ADRA1A

7.54e-06296221223784
Pubmed

{alpha}1-Adrenergic receptor subtypes in nonfailing and failing human myocardium.

ADRA1B ADRA1A

7.54e-06296219919991
Pubmed

Knockout of the alpha 1A/C-adrenergic receptor subtype: the alpha 1A/C is expressed in resistance arteries and is required to maintain arterial blood pressure.

ADRA1A BAIAP2

7.54e-06296212093905
Pubmed

Nuclear alpha1-adrenergic receptors signal activated ERK localization to caveolae in adult cardiac myocytes.

ADRA1B ADRA1A

7.54e-06296218802028
Pubmed

Interaction of HRP-2 isoforms with HDGF: chromatin binding of a specific heteromer.

HDGFL2 HDGF

7.54e-06296222212508
Pubmed

GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus.

GPR89B GPR89A

7.54e-06296218794847
Pubmed

Differences in the signaling pathways of α(1A)- and α(1B)-adrenoceptors are related to different endosomal targeting.

ADRA1B ADRA1A

7.54e-06296223717684
Pubmed

Abnormal myocardial contraction in alpha(1A)- and alpha(1B)-adrenoceptor double-knockout mice.

ADRA1B ADRA1A

7.54e-06296214519431
Pubmed

Dissecting the roles of the 5' exoribonucleases Xrn1 and Xrn2 in restricting hepatitis C virus replication.

XRN2 XRN1

7.54e-06296225673723
Pubmed

LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.

SLC25A3 SURF4 XRN1 ARFGEF2 TRIP12 CNOT1

2.14e-0520296633005030
Pubmed

Gene expressions and mechanical functions of α1-adrenoceptor subtypes in mouse ureter.

ADRA1B ADRA1A

2.26e-05396219259685
Pubmed

GATA4 is a survival factor in adult cardiac myocytes but is not required for alpha1A-adrenergic receptor survival signaling.

ADRA1B ADRA1A

2.26e-05396218552157
Pubmed

The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype.

ADRA1B ADRA1A

2.26e-0539628183249
Pubmed

Blockade of both alpha1A- and alpha1B-adrenergic receptor subtype signaling is required to inhibit neointimal formation in the mouse femoral artery.

ADRA1B ADRA1A

2.26e-05396217384126
Pubmed

Role of α₁-adrenoceptor subtypes in pupil dilation studied with gene-targeted mice.

ADRA1B ADRA1A

2.26e-05396225425303
Pubmed

Localizations and expressions of alpha-1A, alpha-1B and alpha-1D adrenoceptors in human ureter.

ADRA1B ADRA1A

2.26e-05396217973108
Pubmed

Unlike Its Paralog LEDGF/p75, HRP-2 Is Dispensable for MLL-R Leukemogenesis but Important for Leukemic Cell Survival.

PSIP1 HDGFL2

2.26e-05396233477970
Pubmed

Different internalization properties of the alpha1a- and alpha1b-adrenergic receptor subtypes: the potential role of receptor interaction with beta-arrestins and AP50.

ADRA1B ADRA1A

2.26e-05396218523139
Pubmed

Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c.

ADRA1B ADRA1A

2.26e-0539628024574
Pubmed

Alpha1-adrenoceptors are required for normal male sexual function.

ADRA1B ADRA1A

2.26e-05396217603545
Pubmed

Examination of alpha 1 adrenoceptor subtypes in the human ureter.

ADRA1B ADRA1A

2.26e-05396217681068
Pubmed

Hepatoma-derived growth factor belongs to a gene family in mice showing significant homology in the amino terminus.

HDGFL2 HDGF

2.26e-0539629299445
Pubmed

Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase.

PSIP1 HDGFL2

2.26e-05396215371438
Pubmed

The alpha(1B)-adrenergic receptor decreases the inotropic response in the mouse Langendorff heart model.

ADRA1B ADRA1A

2.26e-05396214659805
Pubmed

The presence and distribution of alpha adrenergic receptors in human renal pelvis and calyces.

ADRA1B ADRA1A

2.26e-05396223877383
Pubmed

Molecular cloning of alpha 1d-adrenergic receptor and tissue distribution of three alpha 1-adrenergic receptor subtypes in mouse.

ADRA1B ADRA1A

2.26e-0539627595531
Pubmed

Alpha 1-adrenergic receptor responses in alpha 1AB-AR knockout mouse hearts suggest the presence of alpha 1D-AR.

ADRA1B ADRA1A

2.26e-05396212595294
Pubmed

Association study of polymorphisms in the GluR7, KA1 and KA2 kainate receptor genes (GRIK3, GRIK4, GRIK5) with schizophrenia.

GRIK4 GRIK5

2.26e-05396216325263
Pubmed

Alternate expression of PEPT1 and PEPT2 in epidermal differentiation is required for NOD2 immune responses by bacteria-derived muramyl dipeptide.

SLC15A1 SLC15A2

2.26e-05396231757425
Pubmed

Functional role of α1-adrenoceptor subtypes in murine ophthalmic arteries.

ADRA1B ADRA1A

2.26e-05396221613371
Pubmed

Downregulation of peptide transporters PEPT1 and PEPT2 by oxidative stress responsive kinase OSR1.

SLC15A1 SLC15A2

2.26e-05396225531100
Pubmed

Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function.

GPR89B GPR89A

2.26e-05396232220963
Pubmed

Alpha- and beta-adrenergic receptor polymorphisms in hypertensive and normotensive offspring.

ADRA1B ADRA1A

2.26e-05396216645408
Pubmed

Up-regulation of α1-adrenoceptors in burn and keloid scars.

ADRA1B ADRA1A

2.26e-05396229089212
Pubmed

Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues.

ADRA1B ADRA1A

2.26e-0539627815325
Pubmed

Role of α1-adrenoceptor subtypes on corneal epithelial thickness and cell proliferation in mice.

ADRA1B ADRA1A

2.26e-05396230257104
Pubmed

Evidence of alpha1-adrenoceptor functional changes in omental arteries of patients with end-stage renal disease.

ADRA1B ADRA1A

2.26e-05396218257748
Pubmed

Specific interactions between gC1qR and alpha1-adrenoceptor subtypes.

ADRA1B ADRA1A

2.26e-05396214626446
Pubmed

Differential regulation of the cell cycle by alpha1-adrenergic receptor subtypes.

ADRA1B ADRA1A

2.26e-05396215297446
Pubmed

Neuron-glia signaling via alpha(1) adrenoceptor-mediated Ca(2+) release in Bergmann glial cells in situ.

ADRA1B ADRA1A

2.26e-05396210493741
Pubmed

Effect of Janus kinase 3 on the peptide transporters PEPT1 and PEPT2.

SLC15A1 SLC15A2

2.26e-05396223934551
Pubmed

Expression profile and functional activity of peptide transporters in prostate cancer cells.

SLC15A1 SLC15A2

2.26e-05396222950754
Pubmed

alpha 1-Adrenergic receptor subtypes differentially control the cell cycle of transfected CHO cells through a cAMP-dependent mechanism involving p27Kip1.

ADRA1B ADRA1A

2.26e-05396212409310
Pubmed

Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.

SLC25A3 GPR89B SURF4 GPR89A RIMS1 CNOT1

2.52e-0520896633230847
Pubmed

Oncogenic role of the SOX9-DHCR24-cholesterol biosynthesis axis in IGH-BCL2+ diffuse large B-cell lymphomas.

DHCR24 BCL2

4.51e-05496234624089
Pubmed

Characterization of heteromeric complexes between chemokine (C-X-C motif) receptor 4 and α1-adrenergic receptors utilizing intermolecular bioluminescence resonance energy transfer assays.

ADRA1B ADRA1A

4.51e-05496232085899
Pubmed

Targeted disruption of the PDZK1 gene in mice causes tissue-specific depletion of the high density lipoprotein receptor scavenger receptor class B type I and altered lipoprotein metabolism.

SCARB1 BCL2

4.51e-05496214551195
Pubmed

Distribution of kainate receptor subunits at hippocampal mossy fiber synapses.

GRIK4 GRIK5

4.51e-05496212954862
Pubmed

Adrenergic Receptors in Individual Ventricular Myocytes: The Beta-1 and Alpha-1B Are in All Cells, the Alpha-1A Is in a Subpopulation, and the Beta-2 and Beta-3 Are Mostly Absent.

ADRA1B ADRA1A

4.51e-05496228219977
Pubmed

Proton-coupled oligopeptide transporter (POT) family expression in human nasal epithelium and their drug transport potential.

SLC15A1 SLC15A2

4.51e-05496221366347
Pubmed

The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology.

SLC15A1 SLC15A2

4.51e-05496212905028
Pubmed

Gene deletion of dopamine beta-hydroxylase and alpha1-adrenoceptors demonstrates involvement of catecholamines in vascular remodeling.

ADRA1B ADRA1A

4.51e-05496215231500
Pubmed

Cerebellar Neurodegeneration and Neuronal Circuit Remodeling in Golgi pH Regulator-Deficient Mice.

GPR89B GPR89A

4.51e-05496231118204
Pubmed

Heteromerization of chemokine (C-X-C motif) receptor 4 with α1A/B-adrenergic receptors controls α1-adrenergic receptor function.

ADRA1B ADRA1A

4.51e-05496225775528
Pubmed

Neuroendocrine Modulation of IL-27 in Macrophages.

ADRA1B ADRA1A

4.51e-05496228835457
Pubmed

Developmental expression patterns of kainate receptors in the mouse spinal cord.

GRIK4 GRIK5

7.50e-05596223076118
Pubmed

Complete Disruption of the Kainate Receptor Gene Family Results in Corticostriatal Dysfunction in Mice.

GRIK4 GRIK5

7.50e-05596228228252
Pubmed

Development of laminar distributions of kainate receptors in the somatosensory cortex of mice.

GRIK4 GRIK5

7.50e-0559629593973
Pubmed

The stimulatory effects of alpha1-adrenergic receptors on TGF-beta1, IGF-1 and hyaluronan production in human skin fibroblasts.

ADRA1B ADRA1A

7.50e-05596224844469
Pubmed

Determination of kainate receptor subunit ratios in mouse brain using novel chimeric protein standards.

GRIK4 GRIK5

7.50e-05596226448475
Pubmed

Biochemical and assembly properties of GluR6 and KA2, two members of the kainate receptor family, determined with subunit-specific antibodies.

GRIK4 GRIK5

7.50e-0559628288598
Pubmed

Kainate receptors: pharmacology, function and therapeutic potential.

GRIK4 GRIK5

7.50e-05596218793656
Pubmed

Kainate receptor subunits underlying presynaptic regulation of transmitter release in the dorsal horn.

GRIK4 GRIK5

7.50e-05596212223554
Pubmed

Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1.

CSNK1G2 CSNK1G1

7.50e-05596221680713
Pubmed

Molecular determinants of kainate receptor trafficking.

GRIK4 GRIK5

7.50e-05596218358623
Pubmed

Preferential assembly of heteromeric kainate and AMPA receptor amino terminal domains.

GRIK4 GRIK5

7.50e-05596229058671
Pubmed

Expression of adrenergic receptors in mouse preimplantation embryos and ovulated oocytes.

ADRA1B ADRA1A

1.12e-04696217636168
Pubmed

Compartment-specific expression of collagens and their processing enzymes in intrapulmonary arteries of IPAH patients.

COL14A1 MMP19

1.12e-04696225840998
Pubmed

Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival.

NTRK1 BCL2

1.12e-04696215492043
Pubmed

Interaction of neuronal nitric oxide synthase with alpha1-adrenergic receptor subtypes in transfected HEK-293 cells.

ADRA1B ADRA1A

1.12e-04696212184796
Pubmed

MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by α1-adrenergic receptors.

ADRA1B ADRA1A

1.12e-04696224567387
Pubmed

N-glycan content modulates kainate receptor functional properties.

GRIK4 GRIK5

1.12e-04696228714086
Pubmed

Yeast two-hybrid screening for proteins that interact with alpha1-adrenergic receptors.

ADRA1B ADRA1A

1.12e-04696215525470
Pubmed

α1-Adrenergic Receptors Function Within Hetero-Oligomeric Complexes With Atypical Chemokine Receptor 3 and Chemokine (C-X-C motif) Receptor 4 in Vascular Smooth Muscle Cells.

ADRA1B ADRA1A

1.12e-04696228862946
InteractionVIPR2 interactions

TMEM41A SURF4 DHCR24 VPS8 GPR89A PGAP4 LMBRD2 ECSIT

2.32e-06194898int:VIPR2
InteractionRTL1 interactions

MAP4K3 MAP4K5 NTRK1

6.86e-069893int:RTL1
InteractionPIGN interactions

SURF4 GPR89A PGAP4 LMBRD2 TMEM63A

1.55e-0571895int:PIGN
Cytoband3q27.2

TMEM41A VPS8

2.82e-04129623q27.2
Cytoband1q21-q23

ADAMTS4 HDGF

3.32e-04139621q21-q23
GeneFamilySolute carriers

SLC25A3 SLC16A5 SLC15A1 SLC15A2 SLC6A16 SLC22A23 SLC6A5 SLC7A10

5.83e-05395628752
GeneFamilyMitogen-activated protein kinase kinase kinase kinases

MAP4K3 MAP4K5

1.15e-045622655
GeneFamilyGlutamate ionotropic receptor kainate type subunits

GRIK4 GRIK5

1.15e-0456221199
GeneFamilyAdrenoceptors

ADRA1B ADRA1A

4.10e-049622169
GeneFamilyPWWP domain containing

PSIP1 HDGF

2.56e-03226221147
GeneFamilyEndogenous ligands|Matrix metallopeptidases

MMP16 MMP19

3.04e-0324622891
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)|Children_(3_yrs) / Lineage, Cell type, age group and donor

KCNH6 SLC15A1 GRIK5 RIMS1 HEPACAM2 MMP16 UNC79

8.38e-08169967b6b5bb6408c1305a00719e1b88a5e1202081faf3
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

KCNH6 GRIK5 RIMS1 HEPACAM2 MMP16 UNC79

1.68e-06167966c87ebfa8c3284ad33579190e148c95bcaf670d17
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

KCNH6 SLC15A1 ASS1 GRIK5 HEPACAM2 UNC79

1.80e-0616996696a2aec9acf8a6f966973c035e5ade456cf47772
ToppCellEpithelial-lung_neuroendocrine_cell_(PNEC)|World / Lineage, Cell type, age group and donor

KCNH6 GRIK5 RIMS1 HEPACAM2 MMP16 UNC79

2.77e-0618296657bf4ffb304324e2e392e196336a530d9f78fe0d
ToppCell356C-Epithelial_cells-Epithelial-B_(AT2)-|356C / Donor, Lineage, Cell class and subclass (all cells)

ABCA3 DHCR24 ASS1 STEAP4 ACSS2 GOLT1A

4.36e-0619796606ed8f293d4ee89f14dc2f43d6cae93bbc02508a
ToppCell356C-Epithelial_cells-Epithelial-B_(AT2)|356C / Donor, Lineage, Cell class and subclass (all cells)

ABCA3 DHCR24 ASS1 STEAP4 ACSS2 GOLT1A

4.36e-06197966c115d0a45545ed24259ad88872231bf4d4d389d2
ToppCellIPF-Epithelial-PNEC|IPF / Disease state, Lineage and Cell class

KCNH6 SLC6A5 HEPACAM2 MMP16 ADGRG6

2.44e-05159965adec82df944fe8699a69ca52534353bef100f2f9
ToppCellIPF-Epithelial-PNEC|World / Disease state, Lineage and Cell class

KCNH6 SLC6A5 HEPACAM2 MMP16 ADGRG6

2.59e-05161965133833729ba8b6d3eef326590ca7476b17602cbb
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_B_(ET)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADRA1A OR9Q1 ABCB11 OVCH1 OR6X1

3.18e-051689658e9046b661642293eee640ead91d43db9d8daae0
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_B_(ET)-Glut_ET_L5_FEZF2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADRA1A OR9Q1 ABCB11 OVCH1 OR6X1

3.18e-05168965c7d66e5d9311ceaab3f144f1516b49b8812976b8
ToppCell10x_5'_v1-Neoplastic|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

FAP ASS1 TM6SF2 MMP16 HDGFL2

3.86e-05175965379f595be2273f662064c920d195a30491aa88d6
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NTRK1 SLC22A23 HEPACAM2 USP3 DOP1B

4.41e-05180965cfc8bfbfd3617aabbb49f9730c29b673ca157e74
ToppCellRA-11._Adipocyte|RA / Chamber and Cluster_Paper

ADRA1A BCL2 ACSS2 MMP19 SLC7A10

4.41e-05180965d48a3d27357f7d184132a6805950f93080146b59
ToppCell5'-Adult-LymphNode-Mesenchymal-fibroblastic-Transitional_Stromal_3_(C3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

ADAMTS4 NTRK1 STEAP4 OVCH1 MMP19

4.53e-05181965ab66a89f316b935d9ba1277426d976b1e9e39757
ToppCell10x5'v1-week_14-16-Myeloid_neutrophil-granulo-eo/baso/mast-eosinophil|week_14-16 / cell types per 3 fetal stages;per 3',per 5'

NTRK1 DHCR24 OR5H2 BCL2 GRIK5

4.90e-05184965ce31684772e47a294155f368e50b49753f7c8e87
ToppCelldroplet-Lung-21m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l17|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ADAMTS4 NTRK1 COL14A1 GRIK5 MMP16

5.03e-051859651b990e3089772be2b38c6d7ea0d1bf22461ae3ea
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ABCA3 SLC16A5 TMEM41A DHCR24 STEAP4

5.16e-05186965acfa68a2afb7d2b51c9b469a1965fe5cc5d5e64e
ToppCell10x3'2.3-week_12-13-Mesenchymal_adipo|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

FAP ADRA1A COL14A1 TM6SF2 SLC7A10

5.29e-05187965f1d0fc625e0e7881b3f290742fd7148d995eb71e
ToppCell10x3'2.3-week_12-13-Mesenchymal_adipo-stroma|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

FAP ADRA1A COL14A1 TM6SF2 SLC7A10

5.29e-0518796502e7246ef5ad41773d14426254e139b156d45c1d
ToppCell10x3'2.3-week_12-13-Mesenchymal_adipo-stroma-adipo-CAR|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

FAP ADRA1A COL14A1 TM6SF2 SLC7A10

5.29e-0518796508c73d125e0638c9e9878165bba2442c266c8a48
ToppCellP03-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

PIEZO1 ASS1 COL14A1 MMP16 ADGRG6

5.43e-051889655eb107122064f0a99dfd445cc87d3766f7257216
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SLC15A2 ASS1 STEAP4 RIMS1 HEPACAM2

5.43e-051889655901b276f2379abf486b8285957277e95f08464e
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D175|Adult / Lineage, Cell type, age group and donor

ABCA3 DHCR24 STEAP4 INO80 ACSS2

5.43e-05188965ec38def1fdbb34ed9b30244806975bd5a4370164
ToppCellP07-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_vein|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase

ASS1 COL14A1 BAIAP2 MMP16 ADGRG6

5.70e-05190965e1b721bb74561fe51c53328a0394c9954e489049
ToppCellCD8+_Memory_T_cell-CV-7|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster

GPR89B TBCK ARFGEF2 LMBRD2 DOP1B

5.85e-051919659454f642c3621370fa23640b631301346b300950
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-goblet|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KCNH6 SLC22A23 HEPACAM2 ACSS2 DOP1B

6.14e-05193965402aad2f9e789ad1f2e1536cdc9ce61de7625427
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

ACER2 RHPN2 SLC22A23 BAIAP2 ADGRG6

6.14e-05193965a5695ce2e24a62026ae28f3dea07ca4a435206b8
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-goblet-Goblet_cell|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KCNH6 SLC22A23 HEPACAM2 ACSS2 DOP1B

6.14e-051939657ee3b1ef5c455f321b4e154ae62c69543fe9b30e
ToppCellAT2|World / shred by cell class for parenchyma

ABCA3 DHCR24 STEAP4 ACSS2 GOLT1A

6.30e-05194965e773f5ef3abce7113a6b7cc7cbe68de873d4a17f
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)-Goblet_(subsegmental)_L.0.4.3.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SLC15A2 DHCR24 STEAP4 RIMS1 HEPACAM2

6.45e-051959652a9a36df1dbc4eac77a8ddbe939ec8a8d6c41464
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ABCA3 DHCR24 STEAP4 ACSS2 GOLT1A

6.45e-051959656617abca0009ad3d8731f515f91ab275f9ea4c40
ToppCellcellseq-Epithelial-Epithelial_Alveolar-AT2-AT2|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ABCA3 DHCR24 STEAP4 ACSS2 GOLT1A

6.45e-051959656867f9c56ea27a17c8c4099aae0d79903c3748a5
ToppCellAT2_cells-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

ABCA3 DHCR24 STEAP4 ACSS2 GOLT1A

6.45e-05195965b0cea3f4e59635913d243612f2e8cf4c7b34e726
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ABCA3 DHCR24 STEAP4 ACSS2 GOLT1A

6.45e-05195965fc0ae145a2118df7cbbc9ac4ca9dc12d26c087c4
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell-Goblet_(subsegmental)|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SLC15A2 DHCR24 STEAP4 RIMS1 HEPACAM2

6.45e-05195965576142b4e75457c0973051bccc4163bd624496af
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-tracheobronchial_goblet_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SLC15A2 DHCR24 STEAP4 RIMS1 HEPACAM2

6.45e-051959658f151066ad3ebd9661ea0b733f03c2ce1518f9ad
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ABCA3 DHCR24 STEAP4 ACSS2 GOLT1A

6.45e-051959653e24570def013d5b0b1ef1d7a5ced7dfd922590b
ToppCellcellseq-Epithelial-Epithelial_Alveolar-AT2|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

ABCA3 DHCR24 STEAP4 ACSS2 GOLT1A

6.45e-05195965955a0a7244cd7eaf006a39e1bd03333baf6f30a4
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.0.3|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ABCA3 DHCR24 STEAP4 ACSS2 GOLT1A

6.45e-0519596537aa6e4123d37de4de42ca68d3020f2a7686ce02
ToppCell3'-Parenchyma_lung-Epithelial|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ABCA3 DHCR24 STEAP4 ACSS2 GOLT1A

6.45e-05195965eec187c087e432417bc346c5d3ead72f58bf3215
ToppCellBronchial-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

CEL OTOF GRIK5 HEPACAM2 UNC79

6.61e-051969654bdc304c0c9d8bebe1a6a8a27e44acd1e8113725
ToppCell3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.1.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

ABCA3 DHCR24 STEAP4 ACSS2 GOLT1A

6.61e-0519696583aeb96a33802949238d8a097086a1812201d1b5
ToppCellBronchial_Biopsy-Epithelial-Club|Bronchial_Biopsy / Tissue, Lineage and Cell class of Lung Cells from 10X

SLC15A2 ASS1 STEAP4 RIMS1 HEPACAM2

6.61e-05196965057d150bdf0cad959fd03ec2d1560a96ba03fae9
ToppCell356C-Epithelial_cells-Epithelial-A_(AT2)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ABCA3 SURF4 DHCR24 STEAP4 GOLT1A

6.77e-051979650de77f04612b66cc637dab5d5432c6e711e5964e
ToppCellAT2_cells-SSc-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

SPINK13 ABCA3 SLC16A5 DHCR24 STEAP4

6.77e-0519796542e49a8ce3118db6c2fd620d70c480b75143c828
ToppCellASK452-Epithelial-Transformed_epithelium|ASK452 / Donor, Lineage and Cell class of Lung cells from Dropseq

ABCA3 DHCR24 STEAP4 ADGRG6 HDGF

6.77e-05197965b22a79a5922c865a360e2afc5506a08a512fa76a
ToppCellNS-critical-d_16-33-Epithelial-Secretory|d_16-33 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

SLC15A2 DHCR24 ASS1 PGAP4 RIMS1

6.77e-05197965a72047b7428c0d4aaf016c1ac23dc30919260fd8
ToppCell356C-Epithelial_cells-Epithelial-A_(AT2)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

ABCA3 SURF4 DHCR24 STEAP4 GOLT1A

6.77e-05197965a01640e31fc33c1ab512b4d3eddae8342ecf182c
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KCNH6 SLC6A5 HEPACAM2 MMP16 UNC79

6.93e-051989658f25e8dff42bad8e779ca618bdb1cb1610667962
ToppCell3'-Broncho-tracheal-Epithelial-Epithelial_transtional-secretory-club_cell|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SLC15A2 ASS1 STEAP4 RIMS1 HEPACAM2

6.93e-05198965778fee7020c82d11ff3984a8e482a23e5d58165f
ToppCellPSB-critical-LOC-Epithelial-Secretory|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

SLC15A2 SURF4 ASS1 STEAP4 RIMS1

6.93e-05198965e4cbe4032dba0da3fd46817ea9ad86ba9217f747
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KCNH6 SLC6A5 HEPACAM2 MMP16 UNC79

6.93e-05198965e3e0aa3ef20b2370f5b133048510677aaa562dfa
ToppCell3'-Pediatric_IBD-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SLC15A1 MYO7B ASS1 TM6SF2 GOLT1A

6.93e-05198965c48b3f026b16d48b8eca9f74dc1e3f3f39a89322
ToppCell3'-GW_trimst-1.5-SmallIntestine-Epithelial-mature_enterocytic|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CEL SLC15A1 MYO7B ASS1 GOLT1A

7.10e-05199965a10768e1cddd2d38291c30d24820a94040a72211
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CEL SLC15A1 MYO7B ASS1 GOLT1A

7.10e-05199965914f66e2b4af323d09fa2340a39cf8051d00a422
ToppCell3'-GW_trimst-1.5-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CEL SLC15A1 MYO7B ASS1 GOLT1A

7.10e-05199965f26c20f5d7470e90eaa79613d0b87bd4865585a8
ToppCellBiopsy_IPF-Epithelial-SCGB3A2+|Biopsy_IPF / Sample group, Lineage and Cell type

SLC15A2 DHCR24 ASS1 STEAP4 RIMS1

7.27e-052009652aaf130d702d18c277d16b6800f006a53ed653fb
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-mature_enterocytic-Enterocyte|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CEL SLC15A1 MYO7B ASS1 GOLT1A

7.27e-052009653e13c9a4ba99a7dfbf738b0fb63fb54b4dee5897
ToppCellTracheal-10x3prime_v2-Epithelial-Epi_airway_secretory|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

SLC15A2 DHCR24 ASS1 STEAP4 RIMS1

7.27e-052009658f811ddd84c037a250d124496b0fbb2e4717011c
ToppCell5'-GW_trimst-2-SmallIntestine-Epithelial-mature_enterocytic|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CEL SLC15A1 MYO7B ASS1 GOLT1A

7.27e-0520096573bfdf068a8ecbefc1e6afe9686df73658ee042f
ToppCellBiopsy_Other_PF-Epithelial-SCGB3A2+|Biopsy_Other_PF / Sample group, Lineage and Cell type

SLC15A2 DHCR24 ASS1 STEAP4 RIMS1

7.27e-05200965631550dc34bcb605ab726645f4024d7828bb7975
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-6|TCGA-Lung / Sample_Type by Project: Shred V9

MYO7B GRIK4 OVCH1 MMP19

8.18e-05106964c36911774d31fdea680e3db300ce9064f5b69554
ToppCellControl-Epithelial_alveolar-Mes-Like-Differentiating_AT1|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SLC15A2 GRIK5 RIMS1 PRORP

1.65e-04127964556aaf88719c83f307fa50dfac151136ed05c8ad
ToppCellrenal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

OTOF GRIK5 PRORP CYP39A1

2.46e-041419649a0f4bee2893da1b13ab89494e6159821d53538b
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

PIEZO1 HEPACAM2 BAIAP2 TM6SF2

2.66e-041449645665dd2839b6c8ddbf5ddb2d22e1ee6073f74c3b
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

SPINK13 SLC22A23 HEPACAM2 MMP16

2.66e-04144964cc11cce43d1af8ac63140d05faf215ae9a10cde1
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD4_c08-GZMK-FOS_h|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)

MAP4K5 COL14A1 RIMS1 TMEM63A

2.80e-04146964deeb2c90a478deac7805e1f0d1466bf5bc42f746
ToppCell368C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

ACER2 INTU MAP4K3 NTRK1

3.27e-04152964ca23261d8ef263cc697b8d7e7cb2afec8bc564f2
ToppCellClub_cells-Donor_06|World / lung cells shred on cell class, cell subclass, sample id

SLC15A1 SLC15A2 ASS1 STEAP4

3.35e-0415396477030b0e033f3635b1bbe7552a28c074ea7bb106
ToppCellFrontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nptxr-Excitatory_Neuron.Slc17a7.Nptxr-Ndst4_(Superficial_layer_pyramidal_cells--dorsal_endopiriform_nucleus_or_piriform_cortex)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

GDPD4 SLC16A5 SLC6A5

3.41e-04639631f609765ed8b3a09095427da5dab7ba03a763192
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.0.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SLC15A2 STEAP4 RIMS1 HEPACAM2

3.52e-0415596462b59cb32b12bd55b19e98786a866d788fc9e4bf
ToppCell10x5'-Liver-Myeloid_Mac-Intestinal_macrophages|Liver / Manually curated celltypes from each tissue

INTU SLC22A23 SCARB1 ADGRG6

3.61e-041569649a897fc79c4fae94c5f2e9012d65297f9225e5e3
ToppCell18-Distal-Epithelial-Basal_cell|Distal / Age, Tissue, Lineage and Cell class

SLC15A2 SLC22A23 ASS1 NIF3L1

3.78e-04158964183f445967e09e871c93d8e94781ed9fec894169
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Papillary_Muscle_Invasive_Urothelial_Carcinoma|TCGA-Bladder / Sample_Type by Project: Shred V9

SLC15A1 GOLT1A USP3 TMEM63A

3.78e-04158964dc559503bab3ec1b9ea54ef2e896d1be33e5344c
ToppCellChildren_(3_yrs)-Epithelial-lung_goblet_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

SLC15A2 RHPN2 STEAP4 RIMS1

4.06e-041619642d63b279d9a5132e1c09b03930bf9039036d24a2
ToppCellfacs-Heart-LA-24m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC25A3 CEL ASS1 STEAP4

4.06e-04161964248487415a0601d57ef2a6692e22a61368d0b9c8
ToppCellClub_cells-Donor_04|World / lung cells shred on cell class, cell subclass, sample id

SLC15A2 STEAP4 PGAP4 GRIK5

4.06e-04161964342f5c61d37df61b35c18f5d258043a8f5cef629
ToppCellFetal_29-31_weeks-Epithelial-club_cell-D062|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

ADRA1B DHCR24 RIMS1 AWAT2

4.16e-041629645c9bc3c3857a99d8a3caf359a7eb279ce9cc1c81
ToppCellTCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Serous_adenocarcinoma|TCGA-Endometrium / Sample_Type by Project: Shred V9

ADRA1B TMEM41A GRIK5 SLC7A10

4.36e-0416496408c725548e751f815b4df778607270498204b353
ToppCell367C-Epithelial_cells-Epithelial-A_(AT2)|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

IL34 ABCA3 DHCR24 GOLT1A

4.36e-04164964b0ed8cb6000ce8bf94444307e4b7b3574fa3fab2
ToppCell367C-Epithelial_cells-Epithelial-A_(AT2)-|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)

IL34 ABCA3 DHCR24 GOLT1A

4.36e-041649643aea6207a011ad55a1aeb2ed9fb54d31b23694b5
ToppCellMultiple_Sclerosis-Other-HSPC|Multiple_Sclerosis / Disease, Lineage and Cell Type

CEL PGAP4 CYP39A1 ADGRG6

4.36e-041649646af5529507d695b347adee4be5ead70f56c9cf55
ToppCellChildren_(3_yrs)-Epithelial-lung_neuroendocrine_cell_(PNEC)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

RIMS1 HEPACAM2 MMP16 UNC79

4.36e-04164964be49af6335f2505065cde2cb9800e4a5516811b1
ToppCell3'-Distal_airway-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

CEL RHPN2 DNAH2 UNC79

4.36e-041649649e16e52f5a634585f26021bcce9b5d5992ff6db0
ToppCellClub-club-12|World / Class top

STEAP4 PRORP ACSS2 SLC7A10

4.46e-041659649b7a31cbdcd2f96b8bd08a4cd4141b92bd5e9062
ToppCelldroplet-Fat-SCAT-30m-Lymphocytic-nan|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC16A5 ADAMTS4 BCL2 HEPACAM2

4.56e-0416696467370c49d7aedcb4eca802095f06b30f6bbf8919
ToppCelldroplet-Fat-SCAT-30m-Lymphocytic|Fat / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC16A5 ADAMTS4 BCL2 HEPACAM2

4.56e-041669647f4e5976ede6478636aa567d6fc2b56ff7295fb8
ToppCellfacs-Kidney-nan-24m-Epithelial|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC25A3 CEL DHCR24 ASS1

4.56e-04166964fe87b444fc0ef6fc20c646c9d2c3c8ce916a70c0
ToppCellClub-club-2|World / Class top

SLC15A2 RHPN2 STEAP4 ACSS2

4.56e-0416696456f11efb6b686b3ee2c34a051f626e3d761b5112
ToppCell3'-Distal_airway-Epithelial-Epithelial_transtional-secretory-nasal_mucosa_goblet_cell-Goblet_(nasal)-Goblet_(nasal)_L.0.2.2.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

SLC15A2 ASS1 PACS2 HEPACAM2

4.77e-04168964de0b00bc405c898d08a06b2e585fb62c0ab9a66e
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC16A5 SLC22A23 ADAM2 HEPACAM2

4.88e-041699644b3a7b4a497178799b6b2f0b744f5fb752cee31a
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Outer_Medullary_Collecting_Duct_Intercalated_Cell_Type_A|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

SLC16A5 SLC22A23 ADAM2 HEPACAM2

4.88e-04169964a4fd646b9bf87225131fca530bd6b52df9eaf489
ToppCellIonocyte|World / Class top

NAPEPLD CEL ABCB11 HEPACAM2

4.99e-04170964d2e592f2a679e6a8d32f2b752d9a3c493e50ced4
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_B_(ET)-Glut_ET_L5_FEZF2-Exc_L5_FEZF2_SCN7A|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ADRA1A OR9Q1 ABCB11 OVCH1

4.99e-04170964a0047551619547971d55165156f61f090948f902
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-Lgr5+_undifferentiated_cell_(Distal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

SLC16A5 PGAP4 TM6SF2 ANKH

4.99e-04170964833b4f44ea1fa673dfc6b43ce45a79fe68ae3b05
ToppCell368C-Myeloid-Macrophage-SPP1+_Macrophage_2|368C / Donor, Lineage, Cell class and subclass (all cells)

SLC15A2 PIEZO1 SCARB1 RNFT1

5.10e-0417196426b34dc069cc15b75a0c13cb8c5d81e074788160
ToppCellTCGA-Prostate-Solid_Tissue_Normal-Prostate_normal_tissue-Prostate_normal_tissue-4|TCGA-Prostate / Sample_Type by Project: Shred V9

ADRA1B ADRA1A SLC16A5 PGAP4

5.10e-04171964cafcb7714110cb361808dbe4b9a4963bb71f5129
ToppCellmetastatic_Brain-Fibroblasts-Undetermined|Fibroblasts / Location, Cell class and cell subclass

CAPN7 CES4A CYP39A1 CNOT1

5.21e-04172964c3822ff7329c3ac38c68c5c38cd67c390682e2a6
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADRA1B OTOF SCARB1 PACS2

5.21e-041729647fb31ccbcd0204c3612986a6bc20d57ed6825e9c
ToppCellfacs-Marrow-Granulocytes-3m-Myeloid-CD4+_macrophage|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ADRA1B OTOF SCARB1 PACS2

5.21e-041729642a4614b3d25e8c6b095e6992d8ca35371dcdb5e1
DrugDoxazosin

KCNH6 ADRA1B ADRA1A

1.39e-066953DB00590
DrugPrazosin

KCNH6 ADRA1B ADRA1A

1.39e-066953DB00457
Drug3-acetylisoquinoline

RRM2B GRIK4 GRIK5

1.39e-066953CID000124656
DrugTerazosin

KCNH6 ADRA1B ADRA1A

1.39e-066953DB01162
DrugTerazosin

ADRA1B ADRA1A BCL2

1.39e-066953ctd:C041226
DrugGuanadrel sulfate [22195-34-2]; Up 200; 7.6uM; HL60; HT_HG-U133A

KCNH6 ADRA1A CLCN4 SLC6A16 NTRK1 COL14A1 OR52A1 TMEM63A

1.95e-062009582575_UP
DrugAR E

MAP4K5 SCARB1 DHCR24 XRN1 STEAP4 BCL2 CABIN1 MMP19

5.48e-06230958CID004369394
Drugifenprodil

ADRA1B ADRA1A SLC6A5 GRIK4 GRIK5

1.19e-0571955CID000003689
DrugSt-1913

ADRA1B ADRA1A

1.72e-052952CID000123528
DrugNeldazosin

ADRA1B ADRA1A

1.72e-052952CID000065908
DrugDL-028

ADRA1B ADRA1A

1.72e-052952CID005487531
Drugquinazosin

ADRA1B ADRA1A

1.72e-052952CID000027486
Drughydroxyphenacetyl aminoclonidine

ADRA1B ADRA1A

1.72e-052952CID000173558
DrugMidodrine

ADRA1B ADRA1A

1.72e-052952DB00211
Drugsulfonterol

ADRA1B ADRA1A

1.72e-052952CID000170372
DrugAC1L27FT

ADRA1B ADRA1A

1.72e-052952CID000016192
Drugpaveril

ADRA1B ADRA1A

1.72e-052952CID000006855
Drugtolazine

ADRA1B ADRA1A

1.72e-052952CID000101252
Drugpiclonidine

ADRA1B ADRA1A

1.72e-052952CID000068914
DrugLidanserin

ADRA1B ADRA1A

1.72e-052952CID000068919
Drugglycylsarcosine

SLC15A1 SLC15A2

1.72e-052952ctd:C004194
DrugFCE 22716

ADRA1B ADRA1A

1.72e-052952CID000125720
DrugSKF 101253

ADRA1B ADRA1A

1.72e-052952CID000135152
DrugASL-7022

ADRA1B ADRA1A

1.72e-052952CID000173406
Drugquinaprilat

SLC15A1 SLC15A2

1.72e-052952ctd:C054501
Drughoquizil

ADRA1B ADRA1A

1.72e-052952CID000030690
DrugMethoxamine

ADRA1B ADRA1A

1.72e-052952DB00723
Drugmoexipril

SLC15A1 SLC15A2

1.72e-052952ctd:C058302
DrugPrestwick_774

ADRA1B ADRA1A

1.72e-052952CID006420011
Drugcompound 44-549

ADRA1B ADRA1A

1.72e-052952CID000191431
Drug5-dembs

ADRA1B ADRA1A

1.72e-052952CID000130379
Druglevomepromazine sulfoxide

ADRA1B ADRA1A

1.72e-052952CID000165566
DrugR 56

ADRA1B ADRA1A

1.72e-052952CID009578362
Drugdihydrolysergic acid amide

ADRA1B ADRA1A

1.72e-052952CID000151000
DrugSt-404

ADRA1B ADRA1A

1.72e-052952CID000191786
DrugAC1MBW4N

ADRA1B ADRA1A

1.72e-052952CID002732234
DrugMyordil

ADRA1B ADRA1A

1.72e-052952CID000011282
Drug5-cfmbs

ADRA1B ADRA1A

1.72e-052952CID000183818
DrugIK29

ADRA1B ADRA1A

1.72e-052952CID000183825
Drugpyrroxan

ADRA1B ADRA1A

1.72e-052952CID000036302
Drugdihydroergonine

ADRA1B ADRA1A

1.72e-052952CID000193205
DrugIndoramin

ADRA1B ADRA1A

1.72e-052952ctd:D007217
Drugpenta-O-ethylquercetin

ADRA1B ADRA1A

1.72e-052952CID000133942
Drugclozapine

ADRA1B ADRA1A SLC6A5 GRIK4 GRIK5 PRORP CABIN1 TAAR6

1.95e-05274958CID000002818
DrugCloxacillin sodium salt [642-78-4]; Up 200; 8.8uM; MCF7; HT_HG-U133A

KCNH6 CLCN4 CEL STEAP4 GRIK5 DOP1B TMEM63A

2.02e-051999572289_UP
Drugrisperidone

KCNH6 ADRA1B ADRA1A SLC6A5 PRORP TAAR6

2.29e-05136956CID000005073
DrugAC1L1KEH

ADRA1B ADRA1A SLC6A5 ABCB11

2.32e-0540954CID000005462
Drugpseudococaine

ADRA1B ADRA1A SLC6A16 SLC6A5 STEAP4 GRIK4 BCL2 GRIK5 CABIN1 MMP16 MMP19

2.57e-055709511CID000002826
DrugTG-1

INTU GRIK4 GRIK5

3.09e-0515953CID000060499
DrugAC1Q5UBL

ADRA1B ADRA1A SLC6A16 SLC6A5 GRIK4 GRIK5

3.41e-05146956CID000005466
DrugRec 15/2739

ADRA1B ADRA1A

5.15e-053952CID000148842
DrugFarial

ADRA1B ADRA1A

5.15e-053952CID000065979
Drugmephentermine

ADRA1B ADRA1A

5.15e-053952CID000003677
Drug1-(2-(3-methoxyphenyl)ethyl)phenoxy-3-(dimethylamino)-2-propanol

ADRA1B ADRA1A

5.15e-053952ctd:C099060
DrugAlfuzosin

ADRA1B ADRA1A

5.15e-053952DB00346
DrugPhenylephrine

ADRA1B ADRA1A

5.15e-053952DB00388
Drugspirapril

SLC15A1 SLC15A2

5.15e-053952ctd:C052555
DrugDapiprazole

ADRA1B ADRA1A

5.15e-053952DB00298
DrugPhendimetrazine

ADRA1B ADRA1A

5.15e-053952DB01579
Drug2-(beta-(3-iodo-4-hydroxyphenyl)ethylaminomethyl)tetralone

ADRA1B ADRA1A

5.15e-053952ctd:C048008
DrugSY28

ADRA1B ADRA1A

5.15e-053952CID000014606
DrugMOPEG sulfate

ADRA1B ADRA1A

5.15e-053952CID000004182
Drug2-FPE

ADRA1B ADRA1A

5.15e-053952CID000127900
Drug4-FPE

ADRA1B ADRA1A

5.15e-053952CID000127903
Drugverticillatine

ADRA1B ADRA1A

5.15e-053952CID000176717
DrugTamsulosin

ADRA1B ADRA1A

5.15e-053952DB00706
Drugabanoquil

ADRA1B ADRA1A

5.15e-053952ctd:C058534
Drugifoxetine

ADRA1B ADRA1A

5.15e-053952CID000071971
DrugDB-6,7-ADTN

ADRA1B ADRA1A

5.15e-053952CID000129816
Drugchlorethylclonidine

ADRA1B ADRA1A

5.15e-053952ctd:C051731
DrugWy 25309

ADRA1B ADRA1A

5.15e-053952CID000133818
Drug6-FPE

ADRA1B ADRA1A

5.15e-053952CID000183822
DrugXB513

ADRA1B ADRA1A

5.15e-053952CID000183813
Drugmetrenperone

ADRA1B ADRA1A

5.15e-053952CID000072005
Drug5,7-dichlorokynurenic acid

INTU SLC6A5 GRIK4 GRIK5

5.22e-0549954CID000001779
Drugnifedipine

ADRA1B ADRA1A CEL COL14A1 GRIK4 BCL2 GRIK5 CABIN1 CYP39A1

6.00e-05415959CID000004485
DrugAzone

RRM2B GRIK4 GRIK5

7.62e-0520953CID000042981
Drugaminothiazole 6

GRIK4 GRIK5

1.03e-044952CID005329388
DrugLabetalol

ADRA1B ADRA1A

1.03e-044952DB00598
Drugtamsulosin

ADRA1B ADRA1A

1.03e-044952ctd:C088482
Drug5-methoxygramine

ADRA1B ADRA1A

1.03e-044952CID000027965
DrugTetraminol

ADRA1B ADRA1A

1.03e-044952CID000125151
Drugsertindole

ADRA1B ADRA1A

1.03e-044952ctd:C066304
Drugabanoquil

ADRA1B ADRA1A

1.03e-044952CID000164088
DrugBE 2254

ADRA1B ADRA1A

1.03e-044952ctd:C010652
Drug5-methylurapidil

ADRA1B ADRA1A

1.03e-044952ctd:C057446
Drugacromelic acid B

GRIK4 GRIK5

1.03e-044952CID000158974
DrugBrn 1074551

GRIK4 GRIK5

1.03e-044952CID000120220
DrugNSC342008

ADRA1B ADRA1A

1.03e-044952CID000072602
Drug4-methyleneglutamic acid

GRIK4 GRIK5

1.03e-044952CID000096407
Drugflupirtine

ABCB11 BCL2

1.03e-044952ctd:C034161
DrugdiCl-HQC

GRIK4 GRIK5

1.03e-044952CID003018579
DrugYM90K

GRIK4 GRIK5 CABIN1

1.17e-0423953CID005486547
Drugsodium

SLC25A3 GPR89B KCNH6 SLC15A1 SLC15A2 SLC6A16 SLC6A5 ABCB11 GRIK4 GRIK5 RIMS1 ANKH SLC7A10

1.48e-049449513CID000000923
Drugphendimetrazine

ADRA1B ADRA1A CEL

1.51e-0425953CID000012460
DrugRamipril

SLC15A1 SLC15A2 BCL2

1.71e-0426953ctd:D017257
DrugI heat

ADRA1B ADRA1A

1.71e-045952CID000122216
DrugLeniquinsin

ADRA1B ADRA1A

1.71e-045952CID000025195
DrugAC1L9NP0

ADRA1B ADRA1A

1.71e-045952CID000449842
Drugpropericiazine

ADRA1B ADRA1A

1.71e-045952CID000004747
Diseasealcohol use disorder (implicated_via_orthology)

ADRA1B ADRA1A MAP4K3 MAP4K5 ACSS2 FADS2B UNC79

2.90e-06195937DOID:1574 (implicated_via_orthology)
Diseasenon-high density lipoprotein cholesterol measurement

CEL MAP4K5 SCARB1 XRN1 ARFGEF2 ABCB11 GRIK5 TM6SF2 USP3 HDGFL2 SLC7A10

1.53e-057139311EFO_0005689
Diseaseaspartate aminotransferase measurement

SLC25A3 IL34 CLCN4 CEL MAP4K5 PIEZO1 SCARB1 DNAH2 ABCB11 BCL2 TM6SF2 GOLT1A

2.72e-059049312EFO_0004736
Diseasepolycystic ovary syndrome (biomarker_via_orthology)

ADRA1B ADRA1A BCL2

3.87e-0521933DOID:11612 (biomarker_via_orthology)
Diseasefasting blood glucose measurement, glucose tolerance test, fasting blood insulin measurement

MAP4K5 ABCB11

9.77e-055932EFO_0004307, EFO_0004465, EFO_0004466
Disease1-myristoyl-2-docosahexaenoyl-GPC (14:0/22:6) measurement

MAP4K5 TM6SF2

9.77e-055932EFO_0800454
Diseaseprolyl endopeptidase FAP measurement

FAP CEL

9.77e-055932EFO_0021856
Diseasered blood cell density measurement

XRN2 ADRA1B MAP4K5 PIEZO1 RRM2B DNAH2 ARFGEF2 BCL2 INO80 USP3 SLC7A10

1.03e-048809311EFO_0007978
Diseaselipoprotein measurement, phospholipid measurement

MAP4K5 SCARB1 ABCB11 TM6SF2

1.54e-0485934EFO_0004639, EFO_0004732
Diseasemean corpuscular hemoglobin concentration

ACER2 INTU XRN2 MAP4K5 PIEZO1 SCARB1 ARFGEF2 ABCB11 BCL2 HDGFL2 SLC7A10 OR52A1

1.83e-0411059312EFO_0004528
Diseaseciliopathy (implicated_via_orthology)

RPGRIP1 MAP4K3 MAP4K5

2.75e-0440933DOID:0060340 (implicated_via_orthology)
Diseaselymphocyte:monocyte ratio

FAP CEL SCARB1 CSNK1G1 BCL2 SLC7A10

3.07e-04288936EFO_0600088
Diseaselevel of Sterol ester (27:1/16:1) in blood serum

MAP4K5 TM6SF2

3.49e-049932OBA_2045190
Diseaseomega-6 polyunsaturated fatty acid measurement

MAP4K5 SCARB1 ABCB11 BCL2 TM6SF2

4.07e-04197935EFO_0005680
Diseaseoleoyl-arachidonoyl-glycerol (18:1/20:4) [1] measurement

MAP4K5 TM6SF2

4.35e-0410932EFO_0800507
Diseaselifestyle measurement, alcohol consumption measurement

INTU PGAP4 GRIK5 SLC7A10

4.89e-04115934EFO_0007878, EFO_0010724
Diseasebilirubin measurement

MAP4K5 PIEZO1 SCARB1 TM6SF2 USP3 HDGFL2 HDGF

5.05e-04442937EFO_0004570
Diseaselevel of Ceramide (d40:1) in blood serum

MAP4K5 TM6SF2

5.31e-0411932OBA_2045185
Diseasephosphatidylcholine 34:4 measurement

MAP4K5 TM6SF2

6.35e-0412932EFO_0010378
Disease1-myristoyl-2-arachidonoyl-GPC (14:0/20:4) measurement

MAP4K5 TM6SF2

6.35e-0412932EFO_0800453
Diseasenon-alcoholic steatohepatitis

MAP4K5 TM6SF2

6.35e-0412932EFO_1001249
Diseasemyeloid white cell count

FAP CEL MAP4K5 NTRK1 PIEZO1 CSNK1G1 VPS8 CES4A BCL2 PRORP

7.43e-049379310EFO_0007988
Diseasefacial pigmentation measurement

CEL SCARB1 TAAR6

7.84e-0457933EFO_0006942
DiseaseBipolar Disorder

ADRA1A NTRK1 GRIK4 BCL2 GRIK5 RIMS1 TAAR6

7.91e-04477937C0005586
Diseasepolyunsaturated fatty acid measurement

MAP4K5 SCARB1 ABCB11 TM6SF2

7.98e-04131934EFO_0010733
Diseaseprotein-glutamine gamma-glutamyltransferase e measurement

RHPN2 MAP4K5 ABCB11

9.11e-0460933EFO_0020690
Diseaselifestyle measurement, anxiety disorder measurement

INTU PGAP4 GRIK5 SLC7A10

9.43e-04137934EFO_0007795, EFO_0010724
Diseasebody surface area

MAP4K5 ASS1 BCL2 BAIAP2 ACSS2 TRIP12 UNC79 ADGRG6

9.76e-04643938EFO_0022196
Diseaseliver fat measurement, liver disease biomarker

MAP4K5 TM6SF2

1.15e-0316932EFO_0006845, EFO_0010821
Diseasetriacylglycerol 50:5 measurement

MAP4K5 TM6SF2

1.15e-0316932EFO_0010412
DiseaseCannabis Dependence

ADRA1A SCARB1

1.30e-0317932C0006870
Diseaseprotein C measurement

MYO7B MAP4K5

1.30e-0317932EFO_0004633
DiseaseAlzheimer's disease (is_marker_for)

NTRK1 ASS1 ADAM2 BCL2 BAIAP2

1.34e-03257935DOID:10652 (is_marker_for)
Diseasetriglyceride measurement, body mass index

MAP4K5 BCL2

1.62e-0319932EFO_0004340, EFO_0004530
Diseaseacetate measurement

MAP4K5 ACSS2

1.80e-0320932EFO_0010112
DiseaseDepression, Bipolar

NTRK1 GRIK4 RIMS1

2.02e-0379933C0005587
Diseasephosphatidylcholine measurement

MAP4K5 SCARB1 GRIK5 TM6SF2 OVCH1

2.08e-03284935EFO_0010226
Diseaseautoimmune disease

FAP CEL SLC15A2 NTRK1

2.22e-03173934EFO_0005140
Diseasediet measurement, HOMA-IR

SLC22A23 ANKH

2.38e-0323932EFO_0004501, EFO_0008111
Diseaseparacentral lobule volume measurement

SLC15A1 GRIK5

2.81e-0325932EFO_0010317
Diseaselinoleic acid measurement

MAP4K5 SCARB1 ABCB11 TM6SF2

2.88e-03186934EFO_0006807
Diseaselysophosphatidylethanolamine 18:2 measurement

MAP4K5 LMBRD2

3.04e-0326932EFO_0010369

Protein segments in the cluster

PeptideGeneStartEntry
AMWFPRRYLPKIFRN

ACER2

106

Q5QJU3
FGEKLLGYFSWVMPV

SLC7A10

306

Q9NS82
IENIYHSKPMRWPFF

ADAM2

676

Q99965
HSKPMRWPFFLFIPF

ADAM2

681

Q99965
FAWGPLNIPFMYLFS

ADGRG6

1086

Q86SQ4
FVLCWLPFFLVMPIG

ADRA1A

281

P35348
RPMFKLVWTPLLAAY

ARFGEF2

891

Q9Y6D5
FFIMPSYWCGKPRAV

ABCA3

486

Q99758
VRRILKFSAPEWPYM

ABCB11

741

O95342
GMFILCWLPFFIALP

ADRA1B

301

P35368
PWYMAELFPFILLGV

CLCN4

326

P51793
LVFKQPWPGIMRTVY

ACSS2

516

Q9NR19
YLFSHPSRMPVYPKW

CEL

436

P19835
VIAPWRMPEFYNRFK

ASS1

141

P00966
MYFLSGWPKRLLCPL

RIC1

1

Q4ADV7
FTRWPKPRCKMYIPL

SPINK13

31

Q1W4C9
FTRFVPKFKVLPYWG

INO80

586

Q9ULG1
AKRKSFIGTPYWMAP

MAP4K3

166

Q8IVH8
IRWMPPESILYRKFT

NTRK1

691

P04629
PEWALPLFLLFLFMY

OR9Q1

21

Q8NGQ5
FYKGVAPLWMRQIPY

SLC25A3

216

Q00325
SFPPDKMPLFQIYRW

DOP1B

2161

Q9Y3R5
KMPLFQIYRWAFIPE

DOP1B

2166

Q9Y3R5
FMYFLRGSLPWQGLK

CSNK1G1

241

Q9HCP0
MFMYFLRGSLPWQGL

CSNK1G2

241

P78368
YFKGWFLIDMVAAIP

KCNH6

341

Q9H252
KVWRYINFKMSPGFP

MMP19

356

Q99542
PKMLGIFWFNVPEIY

OR52A1

81

Q9UKL2
GLTYQPEWKMPLFLV

OR5H2

21

Q8NGV7
MLSPTFVLWDVGYPL

FAM205C

1

A6NFA0
NLEFNWLLPYIMKFP

CES4A

351

Q5XG92
VFAKMKGYPHWPARI

HDGF

16

P51858
GKWFVKPELRPFYNM

GDPD4

281

Q6W3E5
RPGFSWPVMLFFSLY

PGAP4

286

Q9BRR3
PDWLGYMRFLVIPLG

PACS2

576

Q86VP3
WLYFFSFLRLGMKAP

TMEM63A

681

O94886
TVWAEPRLQIPMYFF

OR6X1

46

Q8NH79
RWPLLGMFLETYGFF

GOLT1A

81

Q6ZVE7
VFAKMKGYPHWPARI

HDGFL2

11

Q7Z4V5
MVIGWYKLFPPSSLV

RIMS1

1651

Q86UR5
VWLPLFMPVYLKLPS

FADS2B

306

A8MWK0
APPVMAYWVVGRLFL

INTU

896

Q9ULD6
LFKSFPGPMDWVPRY

ADAMTS4

596

O75173
MPRGFTWLRYLGIFL

IL34

1

Q6ZMJ4
PYILTLGAFFWMPFL

AWAT2

136

Q6E213
YLKAMGHKFLVRWPP

CABIN1

491

Q9Y6J0
AYPMPFCDRWGKLPL

CAPN7

236

Q9Y6W3
MYFFWKLGDPFPILS

GPR89A

121

B7ZAQ6
MYFFWKLGDPFPILS

GPR89B

121

P0CG08
RKMRYWLLPPFLAIV

COL14A1

6

Q05707
FRYLFGWMVPPKISL

DHCR24

351

Q15392
MVKFPALTHYWPLIR

ANKH

1

Q9HCJ1
MLSPFWLHRNPKYFP

CYP39A1

366

Q9NYL5
IIWLFERPHTMPKYL

HEPACAM2

66

A8MVW5
DPFSPGVWLFMLLAY

GRIK4

541

Q16099
PFSPAVWLFMLLAYL

GRIK5

541

Q16478
SWRYPPNAPFYKIMV

DNAH2

2376

Q9P225
TRVMFLYIPLPMFWA

SLC15A1

281

P46059
RVLFLYIPLPMFWAL

SLC15A2

301

Q16348
SYPMLKLVRLKLWFP

ECSIT

191

Q9BQ95
KRKSFIGTPYWMAPE

MAP4K5

171

Q9Y4K4
KGFLPTLGPAWVNMY

OTOF

526

Q9HC10
WMFPLERDFYPKARG

PAFAH2

261

Q99487
RYGFLWPGLNVPLMK

MRPS5

136

P82675
FLLFLRLFPMTPNWF

TMEM41A

156

Q96HV5
GVLEYWMRLRFPIKP

RPGRIP1

746

Q96KN7
LPPSVFWSFIFFLML

SLC6A16

491

Q9GZN6
MNPLIYALFYPWFRK

TAAR6

306

Q96RI8
RLPLSPFWAIIFFLM

SLC6A5

556

Q9Y345
FKPWSYIPDGIMPIF

LMBRD2

96

Q68DH5
CPFLLMLLYWSIFPE

SLC22A23

351

A1A5C7
PWKPGVFARVMIFLD

OVCH1

791

Q7RTY7
LSFNMWKEIPIPFYL

SCARB1

51

Q8WTV0
LKPSLKVWMTFPYGR

VPS8

331

Q8N3P4
AFWTIPVYKPMHDFL

SURF4

221

O15260
SYHPPIFRPMKRITW

NIF3L1

91

Q9GZT8
MTFYLFGIRSFPKLW

PRORP

1

O15091
FGIRSFPKLWKSPYL

PRORP

6

O15091
FPPTRQMGLLFTWYD

RHPN2

186

Q8IUC4
TKMRGWFPFSYTRVL

BAIAP2

421

Q9UQB8
LYGPSMRPLFDFSWL

BCL2

201

P10415
GMEVFPVDLIYRPWK

CNOT1

386

A5YKK6
IFAKMKGYPHWPARV

PSIP1

11

O75475
RFVIFPIQYPDIWKM

RRM2B

41

Q7LG56
ITLWYKMILPPQFDR

FAP

516

Q12884
LVPSFIMPFKSKGYW

RNFT1

271

Q5M7Z0
YILGVMWSVLGFPLP

SLC16A5

241

O15375
WLQKYGYLPPTDPRM

MMP16

46

P51512
MGVPAFFRWLSRKYP

XRN2

1

Q9H0D6
MGVPKFYRWISERYP

XRN1

1

Q8IZH2
LFPMWRFPFYLSAVL

STEAP4

196

Q687X5
GFIPDLYAIPWFLTM

TBCK

616

Q8TEA7
MWPFRLRCPIYFKTR

nan

1

Q6ZVL8
SLFYVVWKIMPNFRG

USP3

241

Q9Y6I4
WAFALPYPRFRPMAS

PIEZO1

841

Q92508
IPYLLVPCWAGMKVF

TM6SF2

176

Q9BZW4
KYFDLGIWTAPISPM

ZSWIM1

16

Q9BR11
LPLGLPFYKWMLRQE

TRIP12

1716

Q14669
LLPKPMEFARVGGYW

UNC79

576

Q9P2D8
PVTLPYQVYFMRKLW

MYO7B

1881

Q6PIF6
IPIGAYEPRWFMKYQ

NAPEPLD

306

Q6IQ20