Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionstructural constituent of skin epidermis

KRT2 KRT3 KRT5 KRT6A KRT6B KRT76 KRT6C

4.34e-1043827GO:0030280
GeneOntologyMolecularFunctionstructural constituent of cytoskeleton

KRT2 KRT5 KRT6A KRT6B SPTAN1

1.98e-04130825GO:0005200
GeneOntologyMolecularFunctionhistone modifying activity

DCAF1 PHF2 KAT6A CDYL DTX3L PCGF3

3.61e-04229826GO:0140993
GeneOntologyBiologicalProcessintermediate filament organization

KRT2 KRT3 KRT5 KRT6A KRT6B KRT76 KRT6C

2.29e-0875847GO:0045109
GeneOntologyBiologicalProcesskeratinization

KRT2 KRT3 KRT5 KRT6A KRT6B KRT76 KRT6C

6.47e-0887847GO:0031424
GeneOntologyBiologicalProcessintermediate filament cytoskeleton organization

KRT2 KRT3 KRT5 KRT6A KRT6B KRT76 KRT6C

1.59e-0799847GO:0045104
GeneOntologyBiologicalProcessintermediate filament-based process

KRT2 KRT3 KRT5 KRT6A KRT6B KRT76 KRT6C

1.70e-07100847GO:0045103
GeneOntologyBiologicalProcesskeratinocyte differentiation

KRT2 KRT3 KRT5 KRT6A KRT6B KRT76 KRT6C

1.21e-05189847GO:0030216
GeneOntologyBiologicalProcesssupramolecular fiber organization

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C COL28A1 SPTAN1 DDR2 RICTOR PRKCQ NEB

2.98e-059578414GO:0097435
GeneOntologyBiologicalProcessepidermal cell differentiation

KRT2 KRT3 KRT5 KRT6A KRT6B KRT76 KRT6C

1.60e-04284847GO:0009913
GeneOntologyCellularComponentkeratin filament

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C

4.75e-0997838GO:0045095
GeneOntologyCellularComponentintermediate filament cytoskeleton

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C SYNE2

1.01e-06263839GO:0045111
GeneOntologyCellularComponentsupramolecular fiber

KRT2 KRT3 KRT5 KRT6A KRT6B DNAH3 KRT8 KRT76 KRT6C KIF26B COL28A1 PPP1R12B SPTAN1 SYNE2 NEB ZNF804A DUSP22

3.12e-0611798317GO:0099512
GeneOntologyCellularComponentintermediate filament

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C

3.35e-06227838GO:0005882
GeneOntologyCellularComponentsupramolecular polymer

KRT2 KRT3 KRT5 KRT6A KRT6B DNAH3 KRT8 KRT76 KRT6C KIF26B COL28A1 PPP1R12B SPTAN1 SYNE2 NEB ZNF804A DUSP22

3.42e-0611878317GO:0099081
GeneOntologyCellularComponentpolymeric cytoskeletal fiber

KRT2 KRT3 KRT5 KRT6A KRT6B DNAH3 KRT8 KRT76 KRT6C KIF26B ZNF804A DUSP22

2.16e-048998312GO:0099513
GeneOntologyCellularComponentZ disc

KRT8 PPP1R12B SPTAN1 SYNE2 NEB

3.40e-04151835GO:0030018
GeneOntologyCellularComponentI band

KRT8 PPP1R12B SPTAN1 SYNE2 NEB

5.24e-04166835GO:0031674
GeneOntologyCellularComponentmicrotubule organizing center attachment site

CLMN SYNE2

8.37e-0411832GO:0034992
GeneOntologyCellularComponentmeiotic nuclear membrane microtubule tethering complex

CLMN SYNE2

8.37e-0411832GO:0034993
GeneOntologyCellularComponentparanodal junction

SPTAN1 NFASC

8.37e-0411832GO:0033010
GeneOntologyCellularComponentnuclear membrane protein complex

CLMN SYNE2

8.37e-0411832GO:0106083
GeneOntologyCellularComponentnuclear membrane microtubule tethering complex

CLMN SYNE2

8.37e-0411832GO:0106094
GeneOntologyCellularComponentparanode region of axon

SPTAN1 NFASC

2.04e-0317832GO:0033270
HumanPhenoFollicular hyperkeratosis

KRT6A KRT6B DDR2 TRIP4

2.10e-0530294HP:0007502
HumanPhenoEpidermal thickening

KRT2 TRAPPC11 KRT5 KRT6A KRT6B KRT6C SYNE2 DDR2 NSMCE2 TRIP4

2.56e-053792910HP:0011368
HumanPhenoPalmoplantar blistering

KRT5 KRT6A KRT6B

2.66e-0511293HP:0007446
HumanPhenoHyperkeratosis

KRT2 TRAPPC11 KRT5 KRT6A KRT6B KRT6C DDR2 TRIP4

3.16e-05233298HP:0000962
HumanPhenoPalmoplantar keratoderma

KRT2 TRAPPC11 KRT5 KRT6A KRT6B KRT6C

3.44e-05114296HP:0000982
HumanPhenoAbnormality of keratinization

KRT2 TRAPPC11 KRT5 KRT6A KRT6B KRT6C DDR2 TRIP4

4.41e-05244298HP:0001035
HumanPhenoPalmoplantar hyperkeratosis

KRT2 TRAPPC11 KRT5 KRT6A KRT6B KRT6C

6.91e-05129296HP:0000972
HumanPhenoLower limb pain

KRT5 KRT6A KRT6B PRKRA

7.42e-0541294HP:0012514
HumanPhenoPalmar hyperkeratosis

KRT2 TRAPPC11 KRT5 KRT6A KRT6B KRT6C

7.53e-05131296HP:0010765
HumanPhenoThickened skin

KRT2 TRAPPC11 KRT5 KRT6A KRT6B KRT6C SYNE2 DDR2 NSMCE2 TRIP4

7.79e-054312910HP:0001072
HumanPhenoPlantar hyperkeratosis

KRT2 TRAPPC11 KRT5 KRT6A KRT6B KRT6C

7.86e-05132296HP:0007556
HumanPhenoEpidermoid cyst

IFNG KRT5 KRT6A KRT6B

1.07e-0445294HP:0200040
HumanPhenoCutaneous cyst

IFNG KRT5 KRT6A KRT6B

1.76e-0451294HP:0025245
HumanPhenoEruptive vellus hair cyst

KRT6A KRT6B

1.86e-044292HP:0025248
HumanPhenoSteatocystoma multiplex

KRT6A KRT6B

1.86e-044292HP:0012035
HumanPhenoAbnormality of the periungual region

IFNG KRT6A KRT6B

2.38e-0422293HP:0100803
HumanPhenoLimb pain

KRT5 KRT6A KRT6B PRKRA

2.72e-0457294HP:0009763
HumanPhenoLinear arrays of macular hyperkeratoses in flexural areas

KRT6A KRT6B

3.10e-045292HP:0007490
HumanPhenoHyperplastic callus formation

KRT6A KRT6B

3.10e-045292HP:0030268
HumanPhenoAbnormality of the plantar skin of foot

KRT2 TRAPPC11 KRT5 KRT6A KRT6B KRT6C

3.27e-04171296HP:0100872
HumanPhenoBlistering by anatomical location

KRT5 KRT6A KRT6B

3.95e-0426293HP:0033800
HumanPhenoProminent antitragus

RAB3GAP2 KAT6A

4.63e-046292HP:0008593
HumanPhenoWhite lesion of the oral mucosa

KRT6A KRT6B KRT6C

4.94e-0428293HP:0025125
HumanPhenoOral leukoplakia

KRT6A KRT6B KRT6C

4.94e-0428293HP:0002745
HumanPhenoOnychogryposis

KRT5 KRT6A KRT6B

5.49e-0429293HP:0001805
HumanPhenoOnychogryposis of toenails

KRT6A KRT6B

6.46e-047292HP:0008401
HumanPhenoOnychogryposis

KRT6A KRT6B

6.46e-047292HP:0001819
DomainKeratin_2_head

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C

8.25e-1424848IPR032444
DomainKeratin_2_head

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C

8.25e-1424848PF16208
DomainKeratin_II

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C

1.74e-1326848IPR003054
DomainIntermediate_filament_CS

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C

3.77e-1063848IPR018039
DomainFilament

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C

1.01e-0971848SM01391
DomainIF

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C

1.13e-0972848PS00226
DomainFilament

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C

1.26e-0973848PF00038
DomainIF

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C

1.75e-0976848IPR001664
DomainKeratin_I

KRT3 KRT8 KRT76

1.02e-0344843IPR002957
DomainRan_BP1

RGPD2 RANBP1

1.28e-0312842PF00638
DomainGrpE_coiled_coil

KRT3 KRT76

1.28e-0312842IPR013805
DomainRANBD1

RGPD2 RANBP1

1.28e-0312842PS50196
DomainHis_Phos_1

PFKFB3 UBASH3B

1.28e-0312842PF00300
DomainHis_Pase_superF_clade-1

PFKFB3 UBASH3B

1.28e-0312842IPR013078
DomainRanBD

RGPD2 RANBP1

1.51e-0313842SM00160
DomainRan_bind_dom

RGPD2 RANBP1

1.51e-0313842IPR000156
DomainHis_PPase_superfam

PFKFB3 UBASH3B

3.60e-0320842IPR029033
Domain-

PFKFB3 UBASH3B

3.60e-03208423.40.50.1240
Domain-

COL28A1 CPNE4 VIT

4.52e-03748433.40.50.410
DomainActinin_actin-bd_CS

CLMN SYNE2

4.76e-0323842IPR001589
DomainSpectrin

SPTAN1 SYNE2

4.76e-0323842PF00435
DomainACTININ_2

CLMN SYNE2

4.76e-0323842PS00020
DomainACTININ_1

CLMN SYNE2

4.76e-0323842PS00019
DomaintRNA-bd_arm

KRT3 CNTLN

5.17e-0324842IPR010978
DomainSH3_9

ARHGAP26 UBASH3B NEB

5.24e-0378843PF14604
DomainVWFA

COL28A1 CPNE4 VIT

6.02e-0382843PS50234
DomainSH3_1

ARHGAP26 SPTAN1 UBASH3B NEB

6.41e-03164844PF00018
DomainVWA

COL28A1 CPNE4 VIT

6.43e-0384843SM00327
DomainSpectrin_repeat

SPTAN1 SYNE2

7.50e-0329842IPR002017
PathwayREACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C

1.45e-07129668M27649
PathwayREACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE

KRT2 KRT5 KRT6A KRT6B KRT8 KRT76

3.13e-0687666MM15351
PathwayREACTOME_KERATINIZATION

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C

7.39e-06217668M27640
PathwayREACTOME_KERATINIZATION

KRT2 KRT5 KRT6A KRT6B KRT8 KRT76

7.87e-05153666MM15343
PathwayREACTOME_DEVELOPMENTAL_BIOLOGY

KRT2 KRT5 KRT6A KRT6B KRT8 KRT76 SPTAN1 NFASC PRKCQ GFRA1

1.05e-045026610MM14537
PathwayREACTOME_INTERACTION_BETWEEN_L1_AND_ANKYRINS

SPTAN1 SCN7A NFASC

4.01e-0431663M877
Pubmed

RNF208, an estrogen-inducible E3 ligase, targets soluble Vimentin to suppress metastasis in triple-negative breast cancers.

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C

1.23e-125784831862882
Pubmed

Charting the molecular network of the drug target Bcr-Abl.

DCAF1 KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C SPTAN1 RAB3GAP2 UBASH3B

2.17e-12266841219380743
Pubmed

New consensus nomenclature for mammalian keratins.

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C

2.86e-126384816831889
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

KRT2 KRT3 RGPD2 KRT5 KRT6A RANBP1 KRT6B KRT8 KRT76 KRT6C PPP1R12B SPTAN1 SYNE2 OGDHL PIP4K2B MPHOSPH10 NEB CADPS2 DNAJC3 TOP2B

1.69e-101442842035575683
Pubmed

Hague (Hag). A new mouse hair mutation with an unstable semidominant allele.

KRT2 KRT5 KRT6A KRT6B KRT8

3.12e-101684512399393
Pubmed

Keratin 6 is not essential for mammary gland development.

KRT5 KRT6A KRT6B KRT8

4.73e-10684416790075
Pubmed

Type II keratins precede type I keratins during early embryonic development.

KRT5 KRT6A KRT6B KRT8

3.95e-09984416180309
Pubmed

Genetic variants in pachyonychia congenita-associated keratins increase susceptibility to tooth decay.

KRT6A KRT6B KRT6C

1.36e-08384329357356
Pubmed

Cytokeratin 5/6 expression in bladder cancer: association with clinicopathologic parameters and prognosis.

KRT5 KRT6A KRT6B

1.36e-08384329587848
Pubmed

Cloning and characterization of multiple human genes and cDNAs encoding highly related type II keratin 6 isoforms.

KRT6A KRT6B KRT6C

1.36e-0838437543104
Pubmed

Phosphorylation of human keratin 8 in vivo at conserved head domain serine 23 and at epidermal growth factor-stimulated tail domain serine 431.

KRT6A KRT8 KRT6C

5.43e-0848439054461
Pubmed

Cytokeratin 5/6 and cytokeratin 8/18 expression in triple negative breast cancers: clinicopathologic significance in South-Asian population.

KRT5 KRT6A KRT8

5.43e-08484329884220
Pubmed

Adenomatous polyposis coli (APC) is required for normal development of skin and thymus.

KRT5 KRT6A KRT6B KRT8

1.19e-071984417002498
Pubmed

Airway hillocks are injury-resistant reservoirs of unique plastic stem cells.

KRT5 KRT6A KRT6B

1.35e-07584338693267
Pubmed

Role for keratins 6 and 17 during wound closure in embryonic mouse skin.

KRT5 KRT6A KRT6B

1.35e-07584312557214
Pubmed

Pachyonychia Congenita

KRT6A KRT6B KRT6C

1.35e-07584320301457
Pubmed

Three epidermal and one simple epithelial type II keratin genes map to human chromosome 12.

KRT5 KRT6A KRT6B

1.35e-0758431713141
Pubmed

The diagnostic utility of D2-40, calretinin, CK5/6, desmin and MOC-31 in the differentiation of mesothelioma from adenocarcinoma in pleural effusion cytology.

KRT5 KRT6A KRT6B

1.35e-07584323075894
Pubmed

AP-2 factors act in concert with Notch to orchestrate terminal differentiation in skin epidermis.

KRT5 KRT6A KRT6B KRT8

1.84e-072184418824566
Pubmed

Identification of 14-3-3sigma mutation causing cutaneous abnormality in repeated-epilation mutant mouse.

KRT5 KRT6A KRT6B

2.70e-07684316239341
Pubmed

p63(+)Krt5(+) distal airway stem cells are essential for lung regeneration.

KRT5 KRT6A KRT6B

2.70e-07684325383540
Pubmed

Transcriptomic analysis of the upper lip and primary palate development in mice.

KRT5 KRT6A KRT6B ARMCX1

3.24e-072484436685938
Pubmed

ACAA2 is a ligand-dependent coactivator for thyroid hormone receptor β1.

KRT2 KRT5 KRT6A KRT6B KRT8 KRT76

3.40e-0711384634474245
Pubmed

Prediction of local recurrence, distant metastases, and death after breast-conserving therapy in early-stage invasive breast cancer using a five-biomarker panel.

KRT5 KRT6A KRT6B

4.72e-07784319720911
Pubmed

Identification of trichoplein, a novel keratin filament-binding protein.

KRT5 KRT6A KRT8

7.54e-07884315731013
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

KRT8 STOX2 PDE3B KIF26B CLMN PPFIBP1 SPTAN1 RAB3GAP2 SYNE2 RICTOR NSMCE2 TSSK1B

1.08e-06861841236931259
Pubmed

Nuclear control of lung cancer cells migration, invasion and bioenergetics by eukaryotic translation initiation factor 3F.

KRT2 KRT6A KRT6B KRT8 KRT6C

1.10e-067584531527668
Pubmed

Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13.

KRT3 KRT6A KRT76

1.13e-06984315737194
Pubmed

The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis.

KRT2 KRT5 RANBP1 KRT8 KRT76 CADPS2

1.25e-0614184632322062
Pubmed

Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes.

KRT2 KRT3 KRT5 KRT6A KRT6B

1.94e-068484529563501
Pubmed

Defining BMP functions in the hair follicle by conditional ablation of BMP receptor IA.

KRT5 KRT6A KRT6B

2.94e-061284314610062
Pubmed

Impaired plasma membrane localization of ubiquitin ligase complex underlies 3-M syndrome development.

KRT5 KRT6A KRT6B KRT8 SLC9C1 CCNB3 PPFIBP1 DEUP1 PRKRA

3.24e-0649684931343991
Pubmed

PHGDH Inhibits Ferroptosis and Promotes Malignant Progression by Upregulating SLC7A11 in Bladder Cancer.

KRT2 KRT5 KRT6A KRT6B

4.78e-064684436147463
Pubmed

Two novel pleiotropic loci associated with osteoporosis and abdominal obesity.

IFNG PRKCQ

5.76e-06284232239398
Pubmed

Directed expression of a chimeric type II keratin partially rescues keratin 5-null mice.

KRT5 KRT8

5.76e-06284224867950
Pubmed

A reporter transgene based on a human keratin 6 gene promoter is specifically expressed in the periderm of mouse embryos.

KRT6A KRT6B

5.76e-06284211118885
Pubmed

PDE3B regulates KRT6B and increases the sensitivity of bladder cancer cells to copper ionophores.

KRT6B PDE3B

5.76e-06284238165426
Pubmed

RABL2 Is Required for Hepatic Fatty Acid Homeostasis and Its Dysfunction Leads to Steatosis and a Diabetes-Like State.

RABL2B RABL2A

5.76e-06284227732084
Pubmed

Cytokeratin 5/6 expression in pT1 bladder cancer predicts intravesical recurrence in patients treated with bacillus Calmette-Guérin instillation.

KRT5 KRT6A

5.76e-06284235527047
Pubmed

Expression of MK6a dominant-negative and C-terminal mutant transgenes in mice has distinct phenotypic consequences in the epidermis and hair follicle.

KRT6A KRT6B

5.76e-06284210550543
Pubmed

The mouse keratin 6 isoforms are differentially expressed in the hair follicle, footpad, tongue and activated epidermis.

KRT6A KRT6B

5.76e-06284210550545
Pubmed

The two functional keratin 6 genes of mouse are differentially regulated and evolved independently from their human orthologs.

KRT6A KRT6B

5.76e-0628429790766
Pubmed

Collapse of the keratin filament network through the expression of mutant keratin 6c observed in a case of focal plantar keratoderma.

KRT6A KRT6C

5.76e-06284223662636
Pubmed

Analysis of relative gene dosage and expression differences of the paralogs RABL2A and RABL2B by Pyrosequencing.

RABL2B RABL2A

5.76e-06284220138207
Pubmed

NK cell-activating receptors require PKC-theta for sustained signaling, transcriptional activation, and IFN-gamma secretion.

IFNG PRKCQ

5.76e-06284218784374
Pubmed

Two novel human RAB genes with near identical sequence each map to a telomere-associated region: the subtelomeric region of 22q13.3 and the ancestral telomere band 2q13.

RABL2B RABL2A

5.76e-06284210444334
Pubmed

Variants in RABL2A causing male infertility and ciliopathy.

RABL2B RABL2A

5.76e-06284233075816
Pubmed

Discovery of a novel murine keratin 6 (K6) isoform explains the absence of hair and nail defects in mice deficient for K6a and K6b.

KRT6A KRT6B

5.76e-06284211489919
Pubmed

Delayed wound healing in keratin 6a knockout mice.

KRT6A KRT6B

5.76e-06284210866680
Pubmed

Introducing a null mutation in the mouse K6alpha and K6beta genes reveals their essential structural role in the oral mucosa.

KRT6A KRT6B

5.76e-06284210953016
Pubmed

The complete cDNA and deduced amino acid sequence of a type II mouse epidermal keratin of 60,000 Da: analysis of sequence differences between type I and type II keratins.

KRT6A KRT6B

5.76e-0628426207530
Pubmed

Cytokeratins mediate epithelial innate defense through their antimicrobial properties.

KRT6A KRT6B

5.76e-06284223006328
Pubmed

RABL2 positively controls localization of GPCRs in mammalian primary cilia.

RABL2B RABL2A

5.76e-06284230578315
Pubmed

Comprehensive Gene Expression Analyses of Immunohistochemically Defined Subgroups of Muscle-Invasive Urinary Bladder Urothelial Carcinoma.

KRT5 KRT6A

5.76e-06284233435173
Pubmed

The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells.

KRT3 KRT8

5.76e-0628426186379
Pubmed

Faciogenital Dysplasia 5 supports cancer stem cell traits in basal-like breast cancer by enhancing EGFR stability.

KRT2 KRT5 KRT6A KRT6B KRT8 SPTAN1

7.22e-0619184633762435
Pubmed

Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.

KRT2 KRT5 KRT6A RANBP1 KRT6B KRT8 KRT76 KRT6C SPTAN1

9.10e-0656484921565611
Pubmed

EGFR suppresses p53 function by promoting p53 binding to DNA-PKcs: a noncanonical regulatory axis between EGFR and wild-type p53 in glioblastoma.

KRT2 KRT5 KRT6B SPTAN1

9.13e-065484435474131
Pubmed

Altered keratinocyte differentiation is an early driver of keratin mutation-based palmoplantar keratoderma.

KRT2 KRT5 KRT6A KRT6B

1.39e-056084431220272
Pubmed

KCTD1/KCTD15 complexes control ectodermal and neural crest cell functions, and their impairment causes aplasia cutis.

KRT5 KRT6A KRT6B

1.50e-052084338113115
Pubmed

A functional reference map of the RNF8 interactome in cancer.

KRT2 KRT3 KRT5 KRT6A KRT6B SPTAN1

1.53e-0521884635831895
Pubmed

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT6C TRIP4 TOP2B

1.59e-0560584928977666
Pubmed

Interaction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP-dependent manner.

KRT5 KRT6A KRT6C SPTAN1 PFKFB3 ARMCX1

1.70e-0522284635941108
Pubmed

Keratin expression provides novel insight into the morphogenesis and function of the companion layer in hair follicles.

KRT6A KRT6B

1.73e-05384217170733
Pubmed

Making a connection: direct binding between keratin intermediate filaments and desmosomal proteins.

KRT5 KRT6A

1.73e-0538427525601
Pubmed

Use of immunohistochemical markers can refine prognosis in triple negative breast cancer.

KRT5 KRT6A

1.73e-05384217650314
Pubmed

Overcoming functional redundancy to elicit pachyonychia congenita-like nail lesions in transgenic mice.

KRT6A KRT6B

1.73e-05384215601842
Pubmed

A role for keratins in supporting mitochondrial organization and function in skin keratinocytes.

KRT6A KRT6B

1.73e-05384232213122
Pubmed

A deregulated integrated stress response promotes interferon-γ-induced medulloblastoma.

IFNG EIF2A

1.73e-05384221688289
Pubmed

Single-cell transcriptomics uncovers the differentiation of a subset of murine esophageal progenitors into taste buds in vivo.

KRT5 KRT8

1.73e-05384236888721
Pubmed

Loss of ATF3 promotes hormone-induced prostate carcinogenesis and the emergence of CK5(+)CK8(+) epithelial cells.

KRT5 KRT8

1.73e-05384226522727
Pubmed

Non-Muscle-Invasive Bladder Carcinoma with Respect to Basal Versus Luminal Keratin Expression.

KRT5 KRT6A

1.73e-05384233086575
Pubmed

Increased CK5/CK8-positive intermediate cells with stromal smooth muscle cell atrophy in the mice lacking prostate epithelial androgen receptor.

KRT5 KRT8

1.73e-05384221754978
Pubmed

Mice expressing a mutant Krt75 (K6hf) allele develop hair and nail defects resembling pachyonychia congenita.

KRT6A KRT6B

1.73e-05384217851587
Pubmed

A small deletion hotspot in the type II keratin gene mK6irs1/Krt2-6g on mouse chromosome 15, a candidate for causing the wavy hair of the caracul (Ca) mutation.

KRT6A KRT6B

1.73e-05384214573483
Pubmed

Loss of keratin 6 (K6) proteins reveals a function for intermediate filaments during wound repair.

KRT6A KRT6B

1.73e-05384214568992
Pubmed

Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions.

IFNG RICTOR

1.73e-05384229425506
Pubmed

Cloning and characterization of cytokeratins 8 and 19 in adult rat striated muscle. Interaction with the dystrophin glycoprotein complex.

KRT8 SPTAN1

1.73e-05384215247274
Pubmed

Identification of a cloned sequence activated during multi-stage carcinogenesis in mouse skin.

KRT6A KRT6B

1.73e-0538421713533
Pubmed

Cytokeratin 5/6, c-Met expressions, and PTEN loss prognostic indicators in triple-negative breast cancer.

KRT5 KRT6A

1.73e-05384224326984
Pubmed

Homologs of Drosophila Fushi-Tarazu factor 1 map to mouse chromosome 2 and human chromosome 9q33.

SPTAN1 NEB

1.73e-0538427789992
Pubmed

Bcl11b/Ctip2 is required for development of lingual papillae in mice.

KRT6A KRT6B KRT8

1.75e-052184327287879
Pubmed

Genetic elimination of Suppressor of fused reveals an essential repressor function in the mammalian Hedgehog signaling pathway.

KRT5 KRT6A KRT6B

2.32e-052384316459298
Pubmed

The epidermal differentiation-associated Grainyhead gene Get1/Grhl3 also regulates urothelial differentiation.

KRT6A KRT6B SNX31

2.32e-052384319494835
Pubmed

Prothymosin-α enhances phosphatase and tensin homolog expression and binds with tripartite motif-containing protein 21 to regulate Kelch-like ECH-associated protein 1/nuclear factor erythroid 2-related factor 2 signaling in human bladder cancer.

KRT2 KRT5 KRT6A

2.65e-052484330719818
Pubmed

Interaction of Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) and Vav3 in the Receptor Activator of Nuclear Factor κB (RANK) Signaling Complex Enhances Osteoclastogenesis.

KRT2 KRT3 KRT5

2.65e-052484327507811
Pubmed

N-Terminomics for the Identification of In Vitro Substrates and Cleavage Site Specificity of the SARS-CoV-2 Main Protease.

DCAF1 MMRN1 KRT6A KRT8 GRIPAP1 PPFIBP1 SPTAN1

2.75e-0536084733111431
Pubmed

Identification of a new sweat gland progenitor population in mice and the role of their niche in tissue development.

KRT5 KRT8

3.45e-05484227693698
Pubmed

Keratin 6 regulates collective keratinocyte migration by altering cell-cell and cell-matrix adhesion.

KRT6A KRT6B

3.45e-05484230389720
Pubmed

A review of the clinical phenotype of 254 patients with genetically confirmed pachyonychia congenita.

KRT6A KRT6B

3.45e-05484222264670
Pubmed

Mouse models in preclinical studies for pachyonychia congenita.

KRT6A KRT6B

3.45e-05484216250208
Pubmed

Interferon γ (IFNγ) Signaling via Mechanistic Target of Rapamycin Complex 2 (mTORC2) and Regulatory Effects in the Generation of Type II Interferon Biological Responses.

IFNG RICTOR

3.45e-05484226645692
Pubmed

Cytokeratin expression during mouse embryonic and early postnatal mammary gland development.

KRT5 KRT8

3.45e-05484219937336
Pubmed

An analysis of cyclin D1, cytokeratin 5/6 and cytokeratin 8/18 expression in breast papillomas and papillary carcinomas.

KRT5 KRT8

3.45e-05484223327593
Pubmed

Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses.

IFNG RICTOR

3.45e-05484225559258
Pubmed

On the role of Eph signalling in thymus histogenesis; EphB2/B3 and the organizing of the thymic epithelial network.

KRT5 KRT8

3.45e-05484219598115
Pubmed

Specific expression of lacZ and cre recombinase in fetal thymic epithelial cells by multiplex gene targeting at the Foxn1 locus.

KRT5 KRT8

3.45e-05484217577402
Pubmed

Genome-wide ENU mutagenesis to reveal immune regulators.

RABL2B RABL2A

3.45e-05484211567631
Pubmed

KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.

KRT2 KRT5 KRT6A KRT6B KRT76 CLMN PPP1R12B ARHGAP26 SPTAN1 OGDHL NFASC CPNE4 PRKRA

3.78e-051431841337142655
Pubmed

mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation.

KRT5 KRT8 RICTOR

3.81e-052784327807348
InteractionKRT28 interactions

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C DEUP1

3.25e-1530849int:KRT28
InteractionPHTF1 interactions

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C

7.83e-1520848int:PHTF1
InteractionKRT25 interactions

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C

1.39e-1235848int:KRT25
InteractionKRT12 interactions

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76

5.53e-1224847int:KRT12
InteractionKRT84 interactions

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C

2.54e-1149848int:KRT84
InteractionKRT20 interactions

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C

2.08e-1063848int:KRT20
InteractionKRT14 interactions

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C CCNB3 RICTOR UBASH3B

4.47e-101928411int:KRT14
InteractionKRT36 interactions

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C

7.81e-1074848int:KRT36
InteractionRNF208 interactions

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C

8.71e-1075848int:RNF208
InteractionDES interactions

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C SPTAN1 NEB

1.11e-091588410int:DES
InteractionKRT6A interactions

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C NDC80 UBASH3B

1.25e-091608410int:KRT6A
InteractionKRT8 interactions

KRT2 KRT3 TRAPPC11 KRT5 KRT6A KRT6B KRT8 GRIPAP1 KRT76 KRT6C NDC80 RICTOR UBASH3B GFRA1

3.70e-094418414int:KRT8
InteractionCRK interactions

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 GABPB2 EPYC KAT6A RICTOR UBASH3B ZNF804A

4.21e-093708413int:CRK
InteractionKRT26 interactions

KRT3 KRT6A KRT6B KRT8 KRT76 KRT6C

6.44e-0935846int:KRT26
InteractionKRT5 interactions

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C RICTOR UBASH3B

7.67e-091938410int:KRT5
InteractionKRT16 interactions

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C RICTOR UBASH3B

9.34e-091978410int:KRT16
InteractionKRT35 interactions

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C

2.02e-08111848int:KRT35
InteractionKRT32 interactions

KRT2 KRT3 KRT5 KRT6B KRT8 KRT76

2.72e-0844846int:KRT32
InteractionKRT13 interactions

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C

2.86e-08116848int:KRT13
InteractionKRT7 interactions

KRT2 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C

4.21e-0880847int:KRT7
InteractionKRT15 interactions

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C DEUP1

5.57e-08178849int:KRT15
InteractionKRT75 interactions

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C NDC80

6.43e-08181849int:KRT75
InteractionKIFC3 interactions

DCAF1 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C NDC80 DEUP1

9.59e-082528410int:KIFC3
InteractionKRT24 interactions

KRT2 KRT3 KRT5 KRT6B KRT8 KRT6C

9.63e-0854846int:KRT24
InteractionKRT33B interactions

KRT2 KRT3 KRT5 KRT6B KRT8 KRT76 KRT6C

1.20e-0793847int:KRT33B
InteractionKRT27 interactions

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C NDC80

1.64e-07202849int:KRT27
InteractionPRPH interactions

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 IARS2 KRT76 KRT6C

1.79e-07204849int:PRPH
InteractionKRT37 interactions

KRT2 KRT3 KRT5 KRT6B KRT8 KRT76 KRT6C

1.98e-07100847int:KRT37
InteractionKRT38 interactions

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C

6.01e-07172848int:KRT38
InteractionDCTN1 interactions

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C NDC80 RAB3GAP2 RICTOR EIF2A

1.00e-064978412int:DCTN1
InteractionKRT17 interactions

KRT2 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C RICTOR UBASH3B

1.05e-06252849int:KRT17
InteractionKRT10 interactions

KRT2 KRT5 KRT6A KRT6B KRT8 KRT76 RICTOR UBASH3B

1.13e-06187848int:KRT10
InteractionKRT18 interactions

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C CCNB3 DNAJC3 GFRA1

1.31e-064198411int:KRT18
InteractionKRT19 interactions

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C NDC80

2.66e-06282849int:KRT19
InteractionUBASH3B interactions

KRT2 KRT5 KRT6A KRT6B KRT8 SPTAN1 UBASH3B

4.17e-06157847int:UBASH3B
InteractionKRT39 interactions

KRT2 KRT3 KRT6B KRT76 NDC80

4.68e-0659845int:KRT39
InteractionKRT6C interactions

KRT5 KRT6A KRT8 KRT6C RICTOR

1.63e-0576845int:KRT6C
InteractionKRT6B interactions

KRT5 KRT6A KRT6B KRT8 NDC80 UBASH3B

1.88e-05132846int:KRT6B
InteractionSHC1 interactions

KRT2 KRT3 KRT5 KRT6A SPTAN1 RAB3GAP2 DDR2 UBASH3B PRKRA

1.98e-05362849int:SHC1
InteractionIQCB1 interactions

CNNM4 KRT2 KRT5 KRT6A RANBP1 KRT6B KRT8 KRT6C SPTAN1

2.35e-05370849int:IQCB1
InteractionINPPL1 interactions

KRT2 KRT3 KRT5 KRT6B KRT6C DDR2 UBASH3B

3.13e-05214847int:INPPL1
InteractionKRT3 interactions

KRT3 KRT5 KRT6A KRT8 DEUP1

3.33e-0588845int:KRT3
InteractionKRT77 interactions

KRT2 KRT5 KRT6A KRT8 RICTOR

5.06e-0596845int:KRT77
InteractionEFNA1 interactions

KRT2 KRT5 KRT6A KRT6B KRT6C

7.09e-05103845int:EFNA1
InteractionZUP1 interactions

KRT2 KRT3 KRT5 KRT6A KRT6B RICTOR

8.85e-05174846int:ZUP1
InteractionEFNA3 interactions

KRT2 KRT5 KRT6A KRT6B KRT6C

8.88e-05108845int:EFNA3
InteractionKRT79 interactions

KRT5 KRT6A KRT8 UBASH3B

1.07e-0459844int:KRT79
InteractionVIM interactions

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C SPTAN1 RICTOR ZNF217 NEB

1.21e-048048412int:VIM
InteractionKRT73 interactions

KRT5 KRT6A KRT8 UBASH3B

1.47e-0464844int:KRT73
InteractionYWHAH interactions

TRAPPC11 KRT8 STOX2 IARS2 PDE3B KIF26B CLMN PPFIBP1 SPTAN1 RAB3GAP2 SYNE2 RICTOR PFKFB3 NSMCE2

1.73e-0411028414int:YWHAH
InteractionRGPD2 interactions

RGPD2 RANBP1 RICTOR

1.90e-0427843int:RGPD2
InteractionINSIG1 interactions

KRT5 RANBP1 KRT8 KRT76 CADPS2

1.90e-04127845int:INSIG1
InteractionFGD5 interactions

KRT2 KRT5 KRT6A KRT6B KRT8 SPTAN1

2.28e-04207846int:FGD5
InteractionNUP43 interactions

DCAF1 PHF2 RANBP1 RAB3GAP2 SYNE2 RICTOR MPHOSPH10 EIF2A ZMYM4 TOP2B

2.68e-046258410int:NUP43
InteractionCBL interactions

KRT2 KRT3 KRT5 KRT6A KRT6B KRT6C SPTAN1 PRKCQ UBASH3B

2.96e-04516849int:CBL
InteractionNDC80 interactions

KRT6A KRT6B KRT8 NDC80 SYNE2 CNTLN DNAJC3

3.26e-04312847int:NDC80
InteractionMEIKIN interactions

KRT8 KRT6C

3.56e-047842int:MEIKIN
InteractionTRIM54 interactions

KRT3 KRT6A KRT6B KRT8 KRT76 KRT6C DEUP1

3.87e-04321847int:TRIM54
InteractionCEP350 interactions

KRT2 KRT8 RABL2B NDC80 KAT6A

3.99e-04149845int:CEP350
InteractionKRT76 interactions

KRT5 KRT6A KRT8 KRT76

4.20e-0484844int:KRT76
InteractionAP2M1 interactions

DCAF1 KRT2 KRT3 KRT5 KRT6A KRT6B CLMN DDR2

4.26e-04430848int:AP2M1
InteractionASB12 interactions

KRT8 PFKFB3 CADPS2

4.52e-0436843int:ASB12
InteractionKRT40 interactions

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C

4.53e-04434848int:KRT40
InteractionKRT74 interactions

KRT5 KRT6A KRT8

4.90e-0437843int:KRT74
InteractionLATS1 interactions

DCAF1 KRT5 KRT6A KRT6C SPTAN1 PFKFB3 NEB ARMCX1

4.96e-04440848int:LATS1
InteractionKRT31 interactions

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C

6.00e-04453848int:KRT31
InteractionYWHAG interactions

TRAPPC11 KRT8 STOX2 IARS2 PDE3B KIF26B CLMN PPFIBP1 SPTAN1 SYNE2 RICTOR PRKCQ PFKFB3 CNTLN

6.10e-0412488414int:YWHAG
InteractionMPHOSPH9 interactions

KRT2 KRT8 NDC80 DEUP1

6.70e-0495844int:MPHOSPH9
Cytoband12q13.13

KRT2 KRT3 KRT5 KRT6A KRT6B KRT76 KRT6C

4.23e-116784712q13.13
CytobandEnsembl 112 genes in cytogenetic band chr12q13

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C

1.15e-06423848chr12q13
CytobandXp11

GRIPAP1 CCNB3

1.47e-0410842Xp11
Cytoband4q35.1

TRAPPC11 STOX2

2.00e-03368424q35.1
GeneFamilyKeratins, type II

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C

1.91e-1427608609
GeneFamilyRAB like GTPases

RABL2B RABL2A

1.08e-045602394
CoexpressionGU_PDEF_TARGETS_DN

KRT3 KRT6A KRT6B KRT8 KRT6C

1.81e-0740845M10480
CoexpressionDESCARTES_FETAL_STOMACH_SQUAMOUS_EPITHELIAL_CELLS

KRT5 KRT6A KRT6B SERPINB10 KRT6C

2.48e-0667845M40299
CoexpressionJI_CARCINOGENESIS_BY_KRAS_AND_STK11_UP

KRT5 KRT6A KRT6B

8.87e-0613843MM743
CoexpressionDCA_UP.V1_DN

IFNG CNNM4 KRT5 PPP1R12B NFASC CNTLN

2.94e-05185846M2760
CoexpressionGSE45365_HEALTHY_VS_MCMV_INFECTION_CD8_TCELL_IFNAR_KO_DN

KRT76 NEXMIF ZNF217 CNTLN NEB DEUP1

3.94e-05195846M10007
CoexpressionAtlasfacebase_RNAseq_e10.5_MaxArch_2500_K3

DCAF1 MMRN1 IARS2 PDE3B HEG1 NDC80 ARHGAP26 SYNE2 ZNF770 CDYL DEPDC1 PRKCQ GREB1 MPHOSPH10 CNTLN PCGF3 TOP2B

6.70e-0612528417facebase_RNAseq_e10.5_MaxArch_2500_K3
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30892_k-means-cluster#1_top-relative-expression-ranked_500

KRT5 KRT6A KRT8 DTX3L GFRA1

1.45e-0578845gudmap_developingLowerUrinaryTract_e14.5_ urethra_500_k1
CoexpressionAtlasfacebase_RNAseq_e10.5_Emin_MedNas_2500

DCAF1 TRAPPC11 STOX2 IARS2 PDE3B HEG1 NEXMIF SYNE2 SNX31 GRIK2 DEPDC1 GREB1 MPHOSPH10 CNTLN PCGF3 ZNF804A DEUP1

3.24e-0514148417facebase_RNAseq_e10.5_Emin_MedNas_2500
CoexpressionAtlasfacebase_RNAseq_e10.5_Emin_MedNas_2500_K1

DCAF1 TRAPPC11 STOX2 IARS2 PDE3B HEG1 NEXMIF SYNE2 DEPDC1 GREB1 MPHOSPH10 CNTLN PCGF3 DEUP1

6.61e-0510608414facebase_RNAseq_e10.5_Emin_MedNas_2500_K1
CoexpressionAtlasEB cord blood_vs_EB blastocyst-Confounder_removed-fold2.0_adjp0.05

KRT5 KRT6A KRT6B SERPINB10 KRT6C CLIC6

8.27e-05181846PCBC_ratio_EB cord blood_vs_EB blastocyst_cfr-2X-p05
CoexpressionAtlasAravindRamakr_EmbryoidBody-LF_top-relative-expression-ranked_500_k-means-cluster#4

KRT5 KRT6A KRT6B KRT6C

8.79e-0559844Arv_EB-LF_500_K4
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k-means-cluster#1_top-relative-expression-ranked_1000

KRT5 KRT6A KRT8 DTX3L CLIC6

1.15e-04120845DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k1_1000
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_top-relative-expression-ranked_1000

PHF2 RANBP1 STOX2 PDE3B RABL2A KIF26B SYNE2 GRIK2 MPHOSPH10 CNTLN TOP2B DEUP1 LRRC17

1.22e-049838413Facebase_RNAseq_e10.5_Neural Epithelium Overlying Lateral Eminence_1000
CoexpressionAtlasDevelopingLowerUrinaryTract_P1_bladder_J_emap-30374_top-relative-expression-ranked_500

KRT5 KRT6A KRT8 PPP1R12B SCN7A SNX31 DTX3L NEB

1.50e-04388848gudmap_developingLowerUrinaryTract_P1_bladder_500_J
ToppCellMesenchymal_cells-Stromal_fibro.|Mesenchymal_cells / Lineage and Cell class

COL28A1 SCN7A CLIC6 GREB1 VIT UBASH3B GFRA1

5.30e-08181847f8d914fdc06aaa75a4dc9158daf574ca28fa5432
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-stromal_related|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KRT2 KRT3 KRT76 KIF26B NFASC PRKCQ GFRA1

7.93e-081928478ad6678df89175c5a4a835c8566f1552df3c996e
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-stromal_related-ICC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KRT2 KRT3 KRT76 KIF26B NFASC PRKCQ GFRA1

7.93e-081928472f5378ea0b2fb2f672a36585d375f675983363a1
ToppCelldistal-1-Epithelial-Proliferating_Basal|1 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KRT5 KRT6A KRT6B ZNF141 KRT6C DEPDC1 NEB

1.01e-0719984793450257180d918c310bca7b5defc74390c48091
ToppCelldistal-Epithelial-Proliferating_Basal|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KRT5 KRT6A KRT6B ZNF141 KRT6C DEPDC1 NEB

1.05e-0720084725cc494ef831511840d8c02ec1bd086635cc7edd
ToppCelldistal-Epithelial-Proliferating_Basal-1|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KRT5 KRT6A KRT6B ZNF141 KRT6C DEPDC1 NEB

1.05e-07200847cc31e8c28d01e6757c5dd7f485db6acf7409a47e
ToppCell3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-stromal_related-ICC|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KRT2 KRT76 EPYC NFASC PRKCQ GFRA1

7.13e-07165846b1bbf5acdfc52bd8c7c7eb356d73b812eb6b908c
ToppCell3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-stromal_related|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KRT2 KRT76 EPYC NFASC PRKCQ GFRA1

7.13e-0716584628f8297ec7b781149cc7ac2f5e441771083b8ee3
ToppCellCOVID-19-Heart-Pericyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

CLMN ARHGAP26 TRPC4 SCN7A NFASC SNX31

1.22e-0618184633cac65ed1ea5e7bd72250495df4f850b143d5aa
ToppCellMesenchymal_cells-Stromal_fibro.|World / Lineage and Cell class

COL28A1 SCN7A CLIC6 GREB1 VIT GFRA1

1.88e-0619584669723b06c2a5c2aaf4d10874b11bca7f06822bdc
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_monocytic|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

KRT3 KRT5 KRT6A KRT6B KRT76 KRT6C

1.94e-0619684603de28e1c963e99623e8b0e33bf2e8ef67dc3baa
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-myeloid-myeloid_monocytic-leukocyte|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

KRT5 KRT6A KRT6B KRT76 KRT6C SYNE2

2.00e-06197846d968d7d5608b175bb567ea3a315bf473ec3be459
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)-myeloid-myeloid_monocytic-leukocyte|tissue-resident_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

KRT3 KRT5 KRT6A KRT6B KRT76 KRT6C

2.00e-06197846e621d4f9d4ba5e3ef17d2b477e5e14ea0251147e
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_basal-Suprabasal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

KRT5 KRT6A KRT8 SERPINB10 OGDHL SNX31

2.06e-06198846de5987588b9fa9ee8c595ba06d7d844ead0e3c74
ToppCellBronchial_Biopsy|World / Tissue, Lineage and Cell class of Lung Cells from 10X

KRT5 KRT6A KRT8 PPP1R12B SYNE2 SNX31

2.06e-06198846f5b7013045b61fc56894f80092f799770dde1c8f
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KRT8 PDE3B PPFIBP1 CLIC6 PFKFB3 CADPS2

2.12e-06199846a4ebb0598e9a0c9f6e39a0db6d0623654c2a7d88
ToppCell390C-Epithelial_cells-Epithelial-H_(AT1)-|390C / Donor, Lineage, Cell class and subclass (all cells)

KRT5 KRT6A KRT6B SNX31 CLIC6

1.31e-0516084518ae6822915d16699beb9047baeef9b006901a35
ToppCell390C-Epithelial_cells-Epithelial-H_(AT1)|390C / Donor, Lineage, Cell class and subclass (all cells)

KRT5 KRT6A KRT6B SNX31 CLIC6

1.31e-05160845830f17bad94de05612fe6d53d39e42a4b3f3e2f3
ToppCellSubstantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Th|Substantia_nigra / BrainAtlas - Mouse McCarroll V32

CNNM4 GREB1 CPNE4 NEB CADPS2

1.57e-051668456a6ed5c7a43fee9a8a9be42dfa99303815b8e8ef
ToppCell3'-Child09-12-SmallIntestine-Epithelial-Tuft-related-Tuft|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

KRT2 KRT8 CCNB3 CLMN OGDHL

1.71e-0516984505e12524d68d409fed386ffad233305683b4575b
ToppCellPND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-VEC-VEC_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

RANBP1 HEG1 CDYL CADPS2 ZMYM4

1.71e-05169845f086b50791e1c93e253eb5e8d6c4bf617b1416c3
ToppCellTCGA-Bladder-Primary_Tumor-Urothelial_Carcinoma-Non-Papillary_Muscle_Invasive_Urothelial_Carcinoma-6|TCGA-Bladder / Sample_Type by Project: Shred V9

KRT5 KRT6A KRT6B NLRP10 KRT6C

1.81e-051718450e78389f8f3d54570a6deb3dd307b865b46307e9
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DDR2 SCN7A NFASC VIT GFRA1

1.81e-051718455d31fc9b60329d4ae3c77e4ca679359d9314397d
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

IFNG STOX2 HEG1 SYNE2 PRKCQ

1.86e-0517284586f52f486d67217fc1b8443ab362c975df2974a4
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

IFNG STOX2 HEG1 SYNE2 PRKCQ

1.86e-05172845fb2df8fea6df5947165f13978f1d1006d15b60fd
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_ILC-NK_cell|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

IFNG STOX2 HEG1 SYNE2 PRKCQ

1.86e-05172845e38ebb216e4ddcd008148fcbaf709b4f3c83706a
ToppCell5'-Adult-Appendix-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PDE3B TRPC4 DDR2 GREB1 GFRA1

1.97e-05174845f90ca117b729436cf452e2ddcec26ba525c5c13b
ToppCellwk_20-22-Epithelial-Proximal_epithelial-Proximal_secretory_3|wk_20-22 / Celltypes from embryonic and fetal-stage human lung

KRT5 KRT6B KRT8 SERPINB10 KIF26B

1.97e-051748459e5fae9ecc7c0111fc8a252e72b89dc89c0d3a7c
ToppCellwk_15-18-Epithelial-Proximal_epithelial-SMG_basal_1|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

KRT6A KRT6B KRT8 KRT6C SNX31

1.97e-05174845aceca0a22bb1e380835e792681cfc9b752fb5496
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

STOX2 PPFIBP1 ARHGAP26 PFKFB3 UBASH3B

2.08e-05176845327a3e81b724252e36d786de92a3ffd721ea6d7b
ToppCellTCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Squamous_Cell_Carcinoma-5|TCGA-Lung / Sample_Type by Project: Shred V9

KRT5 KRT6A KRT6B KRT6C SNX31

2.14e-05177845a0c7d08469c513cecf87777c19876884f1511570
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KIF26B TRPC4 SCN7A GREB1 UBASH3B

2.26e-05179845d1365d48d1b017a7917f4f63a82ac4720c3d87df
ToppCellwk_15-18-Epithelial-PNS-KCNIP4+_neuron|wk_15-18 / Celltypes from embryonic and fetal-stage human lung

NEXMIF OGDHL NFASC GRIK2 ZNF804A

2.26e-05179845e20bfdfb6d5af8556eb66b81a19fbe4e3e28334a
ToppCell390C-Fibroblasts-Fibroblast-G|390C / Donor, Lineage, Cell class and subclass (all cells)

NEXMIF TRPC4 DDR2 SCN7A LRRC17

2.32e-05180845137fc14859c89e1ecd98bee388bb58c04b835847
ToppCell390C-Fibroblasts-Fibroblast-G-|390C / Donor, Lineage, Cell class and subclass (all cells)

NEXMIF TRPC4 DDR2 SCN7A LRRC17

2.32e-05180845cd6790de050151fedfa2c5ea6ad58b72665414b2
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KIF26B TRPC4 GREB1 UBASH3B ZNF804A

2.57e-051848452ba98708dfd7f1b2a661578a334684094ff453ad
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-kidney_interstitial_fibroblast_5|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

KRT6A TRPC4 DDR2 NFASC GFRA1

2.57e-05184845c5436a8e45f471b8d1301abbe9c7879204537f52
ToppCellCOVID-19-Heart-Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

CLMN ARHGAP26 TRPC4 NFASC SNX31

2.57e-0518484521790cdfa3b4036ad413fd44b94e31563116f25f
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L1-3_PVALB_WFDC2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KIF26B TRPC4 CLIC6 UBASH3B ZNF804A

2.64e-05185845e87e6e097dc29ece8aea671935bde281b99b93ea
ToppCellControl-Fibroblasts-Adventitial_FB|Control / group, cell type (main and fine annotations)

DDR2 SCN7A GREB1 VIT GFRA1

2.85e-05188845706a26c372add839d947749f0521a0e1f5c9b0ec
ToppCellCF-Lymphoid-T_cell_&_NK_cell|Lymphoid / Disease state, Lineage and Cell class

IFNG PDE3B ARHGAP26 SYNE2 PRKCQ

2.85e-0518884515057036b46c9df621ec4955aa94ca3036245d45
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

STOX2 PPFIBP1 ARHGAP26 PRKCQ UBASH3B

2.85e-0518884563a4b25a0a6e05f80f1a6dd91b817f3cf49e6b68
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KIF26B TRPC4 SCN7A GREB1 ZNF804A

2.85e-051888458de5a07301f9b5984680c873e5a92395b5ed3dd3
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

MMRN1 STOX2 KIF26B PPFIBP1 NFASC

2.85e-051888452db80767903703e7e0a1a37c598f7877a909ee94
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

STOX2 PPFIBP1 SYNE2 PFKFB3 UBASH3B

2.93e-05189845904b8337e2cabac2f0bf5dad5598fc429581ed81
ToppCellCOPD-Lymphoid-T_Cytotoxic|Lymphoid / Disease state, Lineage and Cell class

IFNG PDE3B ARHGAP26 PRKCQ PFKFB3

3.00e-0519084510bece40d980d37a01dae8ce887655bf9f93040c
ToppCellPND10|World / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

HEG1 SPTAN1 DDR2 KAT6A SCN7A

3.00e-05190845d67e2814047c8df2ae4b7bc8be9539f5df6ecef2
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KIF26B TRPC4 SCN7A GREB1 ZNF804A

3.00e-051908453f22c118d552345f731d4d49f0bcb5765d93de3b
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KIF26B TRPC4 SCN7A GREB1 ZNF804A

3.00e-0519084539ab890104b4264c68a968f920f4ccd84f0bc681
ToppCellCOVID-19-Heart-EC_+_Pericyte|Heart / Disease (COVID-19 only), tissue and cell type

CLMN ARHGAP26 TRPC4 SYNE2 NFASC

3.00e-05190845a21653bfb7bafbc273f94fa7c13bfb48cf8fd562
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

STOX2 PPFIBP1 SYNE2 PFKFB3 UBASH3B

3.08e-05191845d0e9afe7b6334dd515d3e68892efdc76347a55e5
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.1|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KRT5 KRT6A KRT8 NDC80 DEPDC1

3.08e-051918450f9443da0f73d07456142fae08b2dc92a5b7b592
ToppCellASK454-Mesenchymal|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

HEG1 DDR2 SCN7A NFASC LRRC17

3.08e-05191845e30ae7a12439f8a79820b13f03e822c1223fd0cb
ToppCell10x3'2.3-week_12-13-Mesenchymal_osteo-stroma-osteoblast_precursor|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

EPYC TRPC4 DDR2 GFRA1 LRRC17

3.08e-0519184598b907f8fa024cf32e462323b782c5a371327bbd
ToppCellASK454-Mesenchymal-Fibroblast|ASK454 / Donor, Lineage and Cell class of Lung cells from Dropseq

HEG1 DDR2 SCN7A NFASC LRRC17

3.08e-051918451726add3f392a061536b7aff72ba84303f4a0b1f
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KIF26B TRPC4 DDR2 NFASC GFRA1

3.16e-051928459093a9e94a25682d109a7f6edc256a25a61103a0
ToppCelldroplet-Kidney-KIDNEY-30m-Mesenchymal-fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPYC DDR2 SCN7A VIT LRRC17

3.16e-05192845853a930e0641ffb50cbb4cef5837c70d75c3fc39
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-high_collagen-matrisome_fibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

KIF26B TRPC4 DDR2 NFASC GFRA1

3.16e-051928459ed5d49621ec1aa01716dc369bba1450b5f015f5
ToppCelldroplet-Kidney-KIDNEY-30m-Mesenchymal-Stroma____fibroblast|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPYC DDR2 SCN7A VIT LRRC17

3.16e-05192845d2c03490c5e835d0f0a732803093c64b8d4b4029
ToppCelldroplet-Kidney-KIDNEY-30m-Mesenchymal|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EPYC DDR2 SCN7A VIT LRRC17

3.16e-0519284549281626ecad0456fdbded2378b7028d7b589686
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KIF26B TRPC4 SCN7A UBASH3B ZNF804A

3.16e-051928450003d7ef9a8e521e70ac33c63aad843d9b6215c2
ToppCellfacs-Heart-RV-3m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DDR2 SCN7A VIT GFRA1 LRRC17

3.23e-05193845735a72fac16397edde95e8eefa6f83caeb5ee5df
ToppCellwk_08-11-Epithelial-Proximal_epithelial-basal_intermediate_|wk_08-11 / Celltypes from embryonic and fetal-stage human lung

KRT5 KRT6A KRT8 SNX31 CPNE4

3.23e-0519384583d2dd823808a2b5ca1a6889eefb541ec042b24c
ToppCellIPF-Lymphoid-T_Cytotoxic|Lymphoid / Disease state, Lineage and Cell class

IFNG PDE3B ARHGAP26 PRKCQ PFKFB3

3.23e-051938453c8a022dbd4f8d25b14fd137ce64c2713a7dbe41
ToppCellAdult-Mesenchymal-matrix_fibroblast_1_cell-D231|Adult / Lineage, Cell type, age group and donor

KIF26B TRPC4 DDR2 SCN7A NFASC

3.23e-05193845ef2f456c094e6e3c6ee81e0668c953cb8d0e1c0a
ToppCellRV-10._Endothelium_II|World / Chamber and Cluster_Paper

MMRN1 PPFIBP1 ARHGAP26 SYNE2 CADPS2

3.23e-051938452531266bc57339d4e2b22a88817008e32b8c1598
ToppCellfacs-Heart-RV-3m-Mesenchymal-fibroblast_of_cardiac_tissue|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DDR2 SCN7A VIT GFRA1 LRRC17

3.23e-05193845ff901d2f3d7a511639c1e3b76058896c0d8a8602
ToppCell3'-Broncho-tracheal-Mesenchymal-Fibroblastic-fibroblastic_type_1-Adventitial_fibroblasts-Adventitial_fibroblasts_L.2.1.0.0|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DDR2 GREB1 VIT GFRA1 LRRC17

3.32e-0519484535b30bc954750e939f81a9a7498b8bc2ce69a299
ToppCellLA-09._Endothelium_I|World / Chamber and Cluster_Paper

MMRN1 SLC9C1 HEG1 SYNE2 CADPS2

3.40e-05195845fc95457a298b5d0dab687d9ee7e225a7f7b9a0d4
ToppCellCOVID_non-vent-Lymphocytic-T_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

PDE3B SPTAN1 SYNE2 KAT6A PRKCQ

3.40e-051958454bdedd924564a260841a9153604026b57487c83d
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PPP1R12B TRPC4 DDR2 NFASC ZNF804A

3.48e-051968451522958a92e0126326a9f0d9fb1c5b5c50b001ea
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Myofibroblast-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

PPP1R12B TRPC4 DDR2 NFASC ZNF804A

3.48e-051968451c8294014713684b50885e638668f2ce75f357f0
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KRT5 KRT6A KRT6B KRT8 KRT6C

3.57e-05197845fb272c9c60ee3d980e528044dc567b4925a23da6
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KRT5 KRT6A KRT6B KRT8 KRT6C

3.57e-0519784561c0d78b29dc4ad8a84172cbfcdab03f31351d0e
ToppCell5'-Airway_Nasal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KRT5 KRT6A KRT6B KRT8 KRT6C

3.57e-05197845dcabea5c50c133c9a4e294e447462d0393174ea7
ToppCell3'-Broncho-tracheal|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KRT5 KRT6A KRT8 SYNE2 SNX31

3.57e-051978455d33f8a6940431093e927b186fb9b630a89d8ec1
ToppCellParenchymal-10x5prime-Epithelial-Epi_airway_basal|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations

KRT5 KRT6A KRT8 SERPINB10 SNX31

3.57e-05197845de772bd2b4cda843777ac879b1087e6444199dfb
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-Reg_T-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

KRT5 KRT6A KRT6B KRT8 KRT6C

3.57e-051978459ee927d005eb17843e2516c8006eb192c6ad2af8
ToppCell10x3'2.3-week_17-19-Mesenchymal_osteo-stroma|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

EPYC DDR2 GRIK2 VIT LRRC17

3.65e-051988451f956e369e00d37835095a001db4b62a79014532
ToppCell10x3'2.3-week_17-19-Mesenchymal_osteo|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

EPYC DDR2 GRIK2 VIT LRRC17

3.65e-05198845dc6fbad0ecdd057189f71afcdb6aca25207314a3
ToppCellcycling_basal_cell|World / shred by cell class for bronchial biopsy

KRT5 KRT6A RANBP1 NDC80 DEPDC1

3.65e-05198845d5306121a75c5eb37d62c353799a98e6ba5ab63f
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-CD4/CD8-Reg_T|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

KRT5 KRT6A KRT6B KRT8 KRT6C

3.65e-051988453371276410dba693c238b383d990b89371b14d8d
ToppCelltumor_Lung-Fibroblasts-Myofibroblasts|tumor_Lung / Location, Cell class and cell subclass

EPYC KIF26B PPFIBP1 DDR2 LRRC17

3.65e-0519884531f9181dab689aabe9c6182c2ef7de65ba3f0ff6
ToppCellAdult-Mesenchymal|Adult / Lineage, Cell type, age group and donor

TRPC4 DDR2 SCN7A NFASC GREB1

3.65e-0519884526e55b409db2a1637c95fae7c54b0abea1ef550c
ToppCellmetastatic_Brain-Fibroblasts-Pericytes|Fibroblasts / Location, Cell class and cell subclass

CLMN PPP1R12B TRPC4 SYNE2 NFASC

3.65e-0519884586a4c8e859ce11a95875f8844963baeb1ba898ec
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-Plasma_B|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

KRT5 KRT6A KRT6B KRT8 KRT6C

3.65e-0519884596236fa22545f6f4ff3aa8dc002963db8a3468ce
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_basal-Dividing_Basal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KRT3 KRT5 KRT6A NDC80 DEPDC1

3.65e-05198845f088badb90c6c2d916195f5649eda102119c9ac6
ToppCellTracheal-NucSeq-Epithelial-Epi_airway_basal-Suprabasal|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KRT5 KRT6A SNX31 CLIC6 UBASH3B

3.65e-0519884519d8ff3a4f911b13ecc34844202925475ad4d2ab
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-Plasma_B-Plasma_B-G|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

KRT5 KRT6A KRT6B KRT8 KRT6C

3.65e-051988459e0fdd63069d17430cdc25bf4ffc762afd5e1728
ToppCellSmart-start-Cell-Wel_seq-Non-neoplastic-Lymphoid-Plasma_B-Plasma_B|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

KRT5 KRT6A KRT6B KRT8 KRT6C

3.65e-051988457eb521af938c2609a85d27e2aa7d4317ad6e1e44
ToppCellproximal-Epithelial-Proliferating_Basal|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KRT5 KRT6A NDC80 SNX31 DEPDC1

3.74e-05199845521ff4ae3437c8ba477a0a42b9da195af976c3ff
ToppCellSmart-seq2-tissue-resident_(Smart-seq2)|Smart-seq2 / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

KRT5 KRT6A KRT6B KRT6C PFKFB3

3.74e-051998458be7cb9d8b4f9707efb69c681c40e683fcd810e5
ToppCellproximal-Epithelial-Proliferating_Basal-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KRT5 KRT6A NDC80 SNX31 DEPDC1

3.74e-05199845e8549b2c4152cb23548351d9cee27c3805892cd8
ToppCellkidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

STOX2 PPFIBP1 PPP1R12B SPTAN1 GFRA1

3.74e-05199845174f6013af6eafa577f84205a62927f2b367fda3
ToppCellproximal-3-Epithelial-Proliferating_Basal|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

KRT5 KRT6A NDC80 SNX31 DEPDC1

3.74e-051998452263bb73d9c5693b44d91d2548305efc1b6e4079
ToppCellSevere-Lymphoid|Severe / Condition, Lineage, Cell class and cell subclass

IFNG PDE3B NDC80 SYNE2 PRKCQ

3.74e-05199845928e346b0f31d991ebab12fefb4eb9f4249e601d
ToppCellSevere-Lymphoid-T|Severe / Condition, Lineage, Cell class and cell subclass

IFNG PDE3B NDC80 SYNE2 PRKCQ

3.74e-05199845ad2be3739721b7bfc2bd50eafd01d4325b01016e
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell-Connecting_Tubule_Cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

PDE3B PPFIBP1 OGDHL CLIC6 CADPS2

3.74e-051998453cd6383c50ce342fe5c175e2e50784d634a90e80
ToppCell10x_3'_v2v3-Neoplastic-Differentiated-like-AC-like-AC-like_Prolif-F|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

RANBP1 NDC80 COL28A1 DEPDC1 CPNE4

3.74e-0519984589d7622c4ae146900d963ac68c6bf011e8674665
ToppCellLung_Parenchyma-Severe-Epithelial-Epithelial-Basal_2|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)

KRT5 KRT6A KRT6B KRT8 KRT6C

3.83e-05200845c7668e26c6b8cfa6d174b0634e43c230425faba9
ComputationalGenes in the cancer module 68.

KRT2 KRT5 KRT6A KRT6B KRT8

2.12e-0726575MODULE_68
ComputationalKeratin.

KRT2 KRT5 KRT6A KRT6B KRT8

2.12e-0726575MODULE_298
ComputationalIntermediate filaments and MT.

KRT2 KRT5 KRT6A KRT6B KRT8

2.83e-0568575MODULE_438
Drugteleocidin B

IFNG KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C PRKCQ

2.88e-111238410CID000072425
Drughomocysteine thiolactone

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 IARS2 KRT76 KRT6C

1.34e-09131849CID000107712
DrugAC1L9MJT

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 ZNF141 HEG1 KRT6C GABPB2

2.31e-091928410CID000448959
Drugal-Badry

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C TOP2B

1.02e-08165849CID000004545
Drugsulfur mustard

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C

2.75e-08130848CID000010461
Drugdithranol

KRT2 KRT6A KRT6B KRT6C

5.07e-0718844CID000002202
Drugplakin

KRT6A KRT6B KRT8 KRT6C SPTAN1 SYNE2

5.89e-0782846CID000018752
DrugSC-791

KRT6A KRT6B KRT6C

9.61e-076843CID010291510
DrugVelcade (bortezomib

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT76 KRT6C CCNB3 TOP2B

1.19e-063748410CID000093860
Drugcignolin

IFNG KRT2 KRT6A KRT6B KRT6C

2.00e-0656845CID000010187
Drug4,4'-thiodiphenol

MMRN1 KRT6A KRT6B KRT6C

5.73e-0632844CID000017570
DrugCiprofloxacin hydrochloride [93107-08-5]; Up 200; 10.8uM; MCF7; HT_HG-U133A

DNAH3 KAT6A PIP4K2B CDYL GREB1 PFKFB3 ZNF804A

7.88e-061958475299_UP
Drug4-hydroxytestosterone

KRT5 KRT6A KRT6B KRT6C NDC80

1.04e-0578845CID000160615
DrugCP-115,953

IFNG TOP2B

1.35e-052842CID000119367
Drugadenosine 3',5'-cyclic phosphate

IFNG KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 PDE3B KRT76 KRT6C PRKCQ CLIC6 PFKFB3

2.66e-059078413CID000000274
Drugclobestasol propionate

KRT6A KRT6B KRT6C

3.17e-0517843CID000002791
Drugmant-GTP

KRT6A KRT6B KRT6C SYNE2

3.49e-0550844CID000128647
DrugOlux

KRT6A KRT6B KRT6C

5.28e-0520843CID000032797
DrugN1-acetylspermidine

KRT6A KRT6B KRT6C

5.28e-0520843CID000000496
DrugDIMIT

KRT5 KRT6A KRT6B KRT6C

5.47e-0556844CID000006624
DrugDubinidine [22964-77-8]; Up 200; 14.6uM; MCF7; HT_HG-U133A

DCAF1 PDE3B CLMN SPTAN1 PIP4K2B PRKCQ

9.02e-051978466250_UP
DrugIsoquinoline, 6,7-dimethoxy-1-methyl-1,2,3,4-tetrahydro, hydrochloride; Up 200; 16.4uM; PC3; HT_HG-U133A

DCAF1 PDE3B ZNF141 HEG1 NFASC NEB

9.02e-051978464226_UP
DrugMK-6

KRT6A KRT6B KRT6C

9.27e-0524843CID005283547
DrugCephalexin monohydrate [23325-78-2]; Down 200; 11uM; PC3; HT_HG-U133A

ZNF141 PPFIBP1 PPP1R12B ARHGAP26 SPTAN1 RAB3GAP2

9.28e-051988464654_DN
Drug1-2q

KRT2 KRT3 KRT5 KRT6A KRT6B KRT8 KRT6C

9.71e-05289847CID000011820
DrugBhg-(2-1)fuc

KRT6A KRT6B KRT6C

1.05e-0425843CID005287784
DiseaseMalignant neoplasm of breast

IFNG CNNM4 KRT5 RANBP1 KRT8 KRT76 PPP1R12B SPTAN1 TRPC4 SYNE2 GRIK2 DTX3L NSMCE2

7.95e-0610748213C0006142
Diseasesphingomyelin measurement

KRT2 KRT5 KRT6A KRT6C PPP1R12B SYNE2 UBASH3B

1.27e-05278827EFO_0010118
DiseasePachyonychia Congenita, Jadassohn Lewandowsky Type

KRT6A KRT6B

4.56e-054822C1706595
Diseasepachyonychia congenita (is_implicated_in)

KRT6A KRT6B

4.56e-054822DOID:0050449 (is_implicated_in)
DiseasePachyonychia congenita syndrome

KRT6A KRT6B

4.56e-054822cv:C0265334
DiseasePachyonychia Congenita, Type 2 (disorder)

KRT6A KRT6B

4.56e-054822C1721007
DiseasePachyonychia Congenita

KRT6A KRT6B

7.59e-055822C0265334
Diseasecutaneous squamous cell carcinoma

KRT5 KRT6A DUSP22

1.06e-0433823EFO_1001927
Diseaseresponse to radiation, Abnormality of the urinary system

TRAPPC11 STOX2

3.38e-0410822GO_0009314, HP_0000079
Diseasesquamous cell carcinoma

KRT5 CDYL DUSP22

8.72e-0467823EFO_0000707
Diseaseserum alanine aminotransferase measurement, response to combination chemotherapy

DDR2 GREB1 CPNE4

1.03e-0371823EFO_0004735, EFO_0007965

Protein segments in the cluster

PeptideGeneStartEntry
NAFLRKEFSDLEKKF

CNTLN

201

Q9NXG0
LKAQFSKLTNNFEKL

DEUP1

96

Q05D60
KFSAFIKNTKKDANE

CLIC6

576

Q96NY7
LKAASKLKNDNTEAF

DNAJC3

211

Q13217
NFKEDSLVKESLAFK

CCNB3

356

Q8WWL7
RFLNAENAQKFKTKF

RANBP1

141

P43487
KKFIAKKLNLSSFNE

PCGF3

186

Q3KNV8
QIKTLNNKFASFIDK

KRT76

186

Q01546
EKEQIKTLNNKFASF

KRT8

91

P05787
DDINVTQKSFNFAKK

RABL2A

136

Q9UBK7
DDINVTQKSFNFAKK

RABL2B

136

Q9UNT1
LFDSKGKNAFFKDLT

RAB3GAP2

1181

Q9H2M9
ENFRKAKQKLGFSSS

DCAF1

276

Q9Y4B6
QIKTLNNKFASFIDK

KRT6C

166

P48668
LAEFKKTNQFFAIKA

PRKCQ

396

Q04759
KLDTEAQTKFKAFLQ

GREB1

741

Q4ZG55
QIKTLNNKFASFIDK

KRT6A

166

P02538
AFSNFGNLRKKKQED

PPFIBP1

906

Q86W92
ALSDLEENDFKKLKF

NLRP10

16

Q86W26
SKKDSFSNLELKFCF

NLRP10

521

Q86W26
EKFKDKDFALDVSAN

DDR2

586

Q16832
LSKCRNDFKFQLKDT

MMRN1

596

Q13201
FSKFKKLKSLDLQQN

LRRC17

101

Q8N6Y2
FFARAAQKLNLSSKK

KIF26B

386

Q2KJY2
QIKTLNNKFASFIDK

KRT2

181

P35908
QIKTLNNKFASFIDK

KRT3

201

P12035
QIKTLNNKFASFIDK

KRT5

171

P13647
KVAFNAFKNKILSDI

TMPRSS15

476

P98073
KKINKNDFASLSDLK

EPYC

156

Q99645
QIKTLNNKFASFIDK

KRT6B

166

P04259
SLKKFLDTAFNLQAF

OGDHL

991

Q9ULD0
KKHFDFLAEFNAKAN

PDE3B

896

Q13370
KKFASALSKFVEEQN

PFKFB3

276

Q16875
KKFLALQSKNSDADF

NSMCE2

106

Q96MF7
NIENFSKDKDSIFKL

DEPDC1

126

Q5TB30
KDKALKSSQAFFSKL

MPHOSPH10

636

O00566
KSSQAFFSKLQDQVK

MPHOSPH10

641

O00566
NKNDISKLIFKSGDF

HEG1

1276

Q9ULI3
KLYANLDLDFAKAKQ

RICTOR

586

Q6R327
DFCRDSNVSLKFNKK

KAT6A

391

Q92794
DLPSDKAKFENFNKA

NFASC

286

O94856
KAKFENFNKALRITN

NFASC

291

O94856
NLKQFSSKDDFKLAV

COL28A1

851

Q2UY09
SKNSQLFAASQKFRK

CDYL

161

Q9Y232
EKANKLAVIKFSDSN

DNAH3

3096

Q8TD57
SLADSKQANKFKQEL

DTX3L

311

Q8TDB6
LKFLNFFKDNTCLKN

GFRA1

326

P56159
FNARKLDDKDFFSKS

CPNE4

161

Q96A23
EFKLQKLKRSQNSAF

CADPS2

331

Q86UW7
NFKDARDAEQLSKNK

DUSP22

16

Q9NRW4
NVKFFNSNKKKRDDF

IFNG

101

P01579
AALANKSFFKADKVT

EIF2A

211

Q9BY44
QKINLYDSFEASKKA

GRIK2

81

Q13002
AYLDKEFSKAQKALS

GRIPAP1

46

Q4V328
FDKSAFDIALEKNNA

GABPB2

136

Q8TAK5
KDNKFSFSFSNKKLL

PHF2

631

O75151
SKCQLSEKFFKAASN

TOP2B

411

Q02880
KSAASALKFDKDLAN

SLC9C1

451

Q4G0N8
IIKKLNENKTFDDSF

SYNE2

3101

Q8WXH0
ADSFKKIFDEAKTAQ

RGPD2

1446

P0DJD1
KSGALKQSSDFSQFK

NEXMIF

351

Q5QGS0
KAKDLPTFKDNDFLN

PIP4K2B

231

P78356
AKRKFADSLNEFKFQ

ARHGAP26

56

Q9UNA1
SFAKAAIEKQKSAFI

IARS2

186

Q9NSE4
KLEAFQKEDSQTKFL

SNX31

246

Q8N9S9
AKAKALFNTLKEQAS

ARMCX1

106

Q9P291
LKASKFNSDLIDFAS

CLMN

561

Q96JQ2
EKNKRDFSAFKDADN

CNNM4

526

Q6P4Q7
DFSAFKDADNELKVK

CNNM4

531

Q6P4Q7
AFFSELKQDTQNALK

TRAPPC11

231

Q7Z392
KKDKTKQLANFSAQF

STOX2

276

Q9P2F5
DLFLTFAKKASAFNS

SPTAN1

2091

Q13813
AAINFALEQLFKKSK

VIT

576

Q6UXI7
KRNAAEKFLAKFSNI

PRKRA

181

O75569
LDNFQSEKKVFKKSF

ZNF770

351

Q6IQ21
KECDKAFKQFSLLSQ

ZNF141

426

Q15928
KDFNIKLSDFSFSKR

TSSK1B

146

Q9BXA7
SAQTKNLKRFFDGAK

ZNF217

551

O75362
KNKTLSEDDFRKFFQ

SCN7A

1506

Q01118
FDLAKAQENSNSVKK

TRIP4

131

Q15650
KKFAADFAAEAASKT

UBASH3B

186

Q8TF42
SKKLAESAQGKNIFF

SERPINB10

16

P48595
DSRLKSSFFDKAANQ

ZMYM4

191

Q5VZL5
NSKDKKKNFSLFDLT

TRPC4

786

Q9UBN4
CFDFKSTKVNNNLDK

ZNF804A

461

Q7Z570
SDLNSKIQSGFFKNK

PPP1R12B

321

O60237
QSKLKDLFNVDAFKL

NDC80

251

O14777
KFKLDTVLQNFSSDK

NEB

406

P20929