Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionglycogen phosphorylase activity

PYGL PYGM

6.56e-053942GO:0008184
GeneOntologyMolecularFunctionhistone modifying activity

SETMAR BRCA2 SETBP1 ASH1L KDM2B PRKDC SUZ12

1.05e-04229947GO:0140993
GeneOntologyMolecularFunctionhistone H3K4 methyltransferase activity

SETMAR SETBP1 ASH1L

1.09e-0420943GO:0042800
GeneOntologyMolecularFunctionguanyl-nucleotide exchange factor activity

DENND10 TIAM1 KALRN RALGPS1 RIN2 ARHGEF38 DENND4C

1.10e-04231947GO:0005085
GeneOntologyMolecularFunction1,4-alpha-oligoglucan phosphorylase activity

PYGL PYGM

2.17e-045942GO:0004645
GeneOntologyMolecularFunctionhistone methyltransferase activity

SETMAR SETBP1 ASH1L SUZ12

3.52e-0471944GO:0042054
GeneOntologyBiologicalProcesschromatin organization

TPR SETMAR GATAD2A ATRX BRCA2 SETBP1 ASH1L TOPBP1 KDM2B SMARCC2 ZNF518B PRKDC SUZ12 TEX15 IFI16

1.08e-058969315GO:0006325
GeneOntologyBiologicalProcesschromatin remodeling

TPR SETMAR GATAD2A ATRX BRCA2 SETBP1 ASH1L KDM2B SMARCC2 PRKDC SUZ12 TEX15 IFI16

2.75e-057419313GO:0006338
GeneOntologyBiologicalProcessprotein-DNA complex organization

TPR SETMAR GATAD2A ATRX BRCA2 SETBP1 ASH1L TOPBP1 KDM2B SMARCC2 ZNF518B PRKDC SUZ12 TEX15 IFI16

3.85e-059999315GO:0071824
GeneOntologyBiologicalProcessribosomal subunit export from nucleus

RAN ABCE1 NMD3

4.76e-0516933GO:0000054
GeneOntologyBiologicalProcessribosome localization

RAN ABCE1 NMD3

4.76e-0516933GO:0033750
GeneOntologyBiologicalProcessnuclear DNA replication

ATRX BRCA2 ATAD5 CDC7

5.47e-0546934GO:0033260
GeneOntologyBiologicalProcesscell cycle DNA replication

ATRX BRCA2 ATAD5 CDC7

8.23e-0551934GO:0044786
GeneOntologyBiologicalProcessmitotic cell cycle process

CUL3 TPR RAN SETMAR ANK3 BRCA2 ATAD5 TOPBP1 SMARCC2 PRKDC ACVR1B USH1C CDC7

1.16e-048549313GO:1903047
GeneOntologyBiologicalProcesscell cycle phase transition

CUL3 TPR SETMAR BRCA2 ATAD5 TOPBP1 SMARCC2 PRKDC ACVR1B USH1C CDC7

1.19e-046279311GO:0044770
GeneOntologyBiologicalProcessRNA import into nucleus

TPR RAN

1.20e-044932GO:0006404
GeneOntologyBiologicalProcessDNA-templated DNA replication

SETMAR ATRX BRCA2 ATAD5 TOPBP1 CDC7

1.55e-04178936GO:0006261
GeneOntologyBiologicalProcessmitotic cell cycle

CUL3 TPR RAN SETMAR AFAP1L2 ANK3 BRCA2 ATAD5 TOPBP1 SMARCC2 PRKDC ACVR1B USH1C CDC7

1.74e-0410149314GO:0000278
GeneOntologyBiologicalProcesschromosome organization

CUL3 TPR RAN SETMAR ATRX BRCA2 TOPBP1 SMARCC2 SGO2 PRKDC TEX15

2.61e-046869311GO:0051276
GeneOntologyBiologicalProcessNMDA selective glutamate receptor signaling pathway

TIAM1 KALRN

2.98e-046932GO:0098989
DomainPHOSPHORYLASE

PYGL PYGM

7.02e-053912PS00102
DomainPhosphorylase

PYGL PYGM

7.02e-053912PF00343
DomainGlycg_phsphrylas

PYGL PYGM

7.02e-053912IPR011833
DomainGlyco_trans_35

PYGL PYGM

7.02e-053912IPR000811
DomainZF_PHD_2

ATRX PHF3 ASXL3 ASH1L KDM2B

1.01e-0495915PS50016
DomainZF_PHD_1

ATRX PHF3 ASXL3 ASH1L KDM2B

1.06e-0496915PS01359
DomainZnf_FYVE_PHD

ATRX SYTL5 PHF3 ASH1L KDM2B

7.62e-04147915IPR011011
DomainSAM

STIM2 DLC1 ANKS1B SAMD4A

9.00e-0488914SM00454
DomainABC_transporter_CS

ABCE1 ABCC5 ABCC12

1.12e-0342913IPR017871
DomainSAM_DOMAIN

STIM2 DLC1 ANKS1B SAMD4A

1.20e-0395914PS50105
DomainSAM

STIM2 DLC1 ANKS1B SAMD4A

1.29e-0397914IPR001660
DomainABC_tran

ABCE1 ABCC5 ABCC12

1.65e-0348913PF00005
DomainABC_TRANSPORTER_2

ABCE1 ABCC5 ABCC12

1.65e-0348913PS50893
DomainABC_TRANSPORTER_1

ABCE1 ABCC5 ABCC12

1.75e-0349913PS00211
DomainABC_transporter-like

ABCE1 ABCC5 ABCC12

1.86e-0350913IPR003439
DomainSAM/pointed

STIM2 DLC1 ANKS1B SAMD4A

2.57e-03117914IPR013761
DomainPost-SET_dom

SETMAR ASH1L

2.70e-0316912IPR003616
DomainGATA_ZN_FINGER_1

GATAD2A ATRX

2.70e-0316912PS00344
DomainPostSET

SETMAR ASH1L

2.70e-0316912SM00508
DomainGATA_ZN_FINGER_2

GATAD2A ATRX

2.70e-0316912PS50114
DomainPOST_SET

SETMAR ASH1L

2.70e-0316912PS50868
DomainDH_1

TIAM1 KALRN ARHGEF38

3.60e-0363913PS00741
DomainRhoGEF

TIAM1 KALRN ARHGEF38

4.46e-0368913SM00325
DomainRhoGEF

TIAM1 KALRN ARHGEF38

4.84e-0370913PF00621
DomainDH_2

TIAM1 KALRN ARHGEF38

4.84e-0370913PS50010
Pubmed

Proteomic characterization of chromosomal common fragile site (CFS)-associated proteins uncovers ATRX as a regulator of CFS stability.

RPL21 TPR RAN RPL32 ATRX BRCA2 ATAD5 UTP14A TOPBP1 SMARCC2 SGO2 PYGM PRKDC

2.68e-08652951331180492
Pubmed

The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.

RPL21 CUL3 RPL32 GATAD2A ATAD5 PHF3 STRBP UTP14A TOPBP1 SGO2 PRKDC SUZ12 SRBD1

1.55e-07759951335915203
Pubmed

Transcription factor Foxp3 and its protein partners form a complex regulatory network.

CUL3 GATAD2A ATAD5 PHF3 STRBP UTP14A TOPBP1 SMARCC2 SUZ12

8.32e-0737095922922362
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

ZNF567 GATAD2A ATRX ATAD5 PHF3 TOPBP1 KDM2B SMARCC2 SGO2 SUZ12 SRBD1

8.82e-07608951136089195
Pubmed

Mapping the Ku Interactome Using Proximity-Dependent Biotin Identification in Human Cells.

TPR GATAD2A ATRX PHF3 STRBP UTP14A PRKDC IFI16

1.15e-0628395830585729
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

TPR RAN GATAD2A ATRX BRCA2 ATAD5 PHF3 STRBP UTP14A TOPBP1 SMARCC2 SGO2 PRKDC

2.01e-06954951336373674
Pubmed

Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.

ZNF7 TARS3 SETMAR GTF3A ANK3 TIAM1 ATRX KALRN KCNJ6 ASH1L ANKS1B CCDC15 ABCC5 SYT4 PRKDC

2.08e-061285951535914814
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

RPL21 RAN RPL32 GATAD2A ATRX ATAD5 PHF3 TOPBP1 KDM2B PRKDC SUZ12 SRBD1 IFI16 MXD4 SAMD4A

2.26e-061294951530804502
Pubmed

Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.

CUL3 TPR RAN GATAD2A ATRX ATAD5 ABCE1 PHF3 SMARCC2 PYGL PRKDC SUZ12 IFI16

3.90e-061014951332416067
Pubmed

The ubiquitin ligase Uhrf2 is a master regulator of cholesterol biosynthesis and is essential for liver regeneration.

TPR ATRX PHF3 UTP14A SGO2

4.00e-068695537253089
Pubmed

MRP5 and MRP9 play a concerted role in male reproduction and mitochondrial function.

ABCC5 ABCC12

7.38e-06295235121660
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

RPL21 RAN STIM2 ATRX PYROXD1 STRBP FAM186A TRO UTP14A ASH1L ANKS1B ABCC5 SMARCC2 PRKDC SRBD1

8.36e-061442951535575683
Pubmed

Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.

ATRX ATAD5 PHF3 UTP14A SMARCC2 SRBD1

9.53e-0617795626206133
Pubmed

Synaptic GAP and GEF Complexes Cluster Proteins Essential for GTP Signaling.

CUL3 ANK3 KALRN PHF3 ANKS1B AKAP11 SIK3

1.26e-0528195728706196
Pubmed

Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains.

RPL21 GATAD2A DSC2 ATRX ATAD5 UTP14A ASH1L SMARCC2 SUZ12

1.59e-0553395930554943
Pubmed

Nucleolar proteome dynamics.

RPL21 TPR RAN POP4 ATRX TOPBP1 PRKDC NMD3

2.02e-0541995815635413
Pubmed

Coordinated nuclear export of 60S ribosomal subunits and NMD3 in vertebrates.

RAN NMD3

2.21e-05395212773398
Pubmed

Biogenesis and nuclear export of ribosomal subunits in higher eukaryotes depend on the CRM1 export pathway.

RAN NMD3

2.21e-05395212724356
Pubmed

Mutation and expression alterations of histone methylation-related NSD2, KDM2B and SETMAR genes in colon cancers.

SETMAR KDM2B

2.21e-05395233621919
Pubmed

Confirmation of mutation landscape of NF1-associated malignant peripheral nerve sheath tumors.

KDM2B SUZ12

2.21e-05395228124441
Pubmed

The role of insulin-like growth factor binding protein-3 in the breast cancer cell response to DNA-damaging agents.

IGFBP3 PRKDC

2.21e-05395223178489
Pubmed

Ankyrin-Tiam1 interaction promotes Rac1 signaling and metastatic breast tumor cell invasion and migration.

ANK3 TIAM1

2.21e-05395210893266
Pubmed

Expression of Tiam-1 in the developing brain suggests a role for the Tiam-1-Rac signaling pathway in cell migration and neurite outgrowth.

TIAM1 KCNJ6

2.21e-0539529204476
Pubmed

BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.

RPL21 TPR RAN STIM2 ANK3 DSC2 ABCE1 ABCC5 PRKDC DENND4C

2.45e-05708951039231216
Pubmed

Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins.

RPL21 RAN STRBP UTP14A TOPBP1 SMARCC2 SGO2 SYT4 SRBD1 NMD3

2.92e-05723951034133714
Pubmed

Mouse screen reveals multiple new genes underlying mouse and human hearing loss.

AP4E1 SETMAR POP4 GSDME DSC2 DACT3 ARHGEF38 ANKS1B SGO2 SIK3 USH1C C3orf20 DENND4C

3.33e-051242951330973865
Pubmed

Comprehensive Interactome Mapping of the DNA Repair Scaffold SLX4 Using Proximity Labeling and Affinity Purification.

FAM32A ATRX BRCA2 TOPBP1 ZNF518B CDC7

3.42e-0522295637071664
Pubmed

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.

STIM2 GATAD2A ATRX ABCE1 RIN2 MRPL30 AKAP11 ACVR1B SIK3 SLC4A4 CDC7

3.91e-05910951136736316
Pubmed

OXTRHigh stroma fibroblasts control the invasion pattern of oral squamous cell carcinoma via ERK5 signaling.

OXTR PRKDC

4.41e-05495236045118
Pubmed

Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line.

RHOQ RAN

4.41e-0549522108320
Pubmed

Elevated HMGN4 expression potentiates thyroid tumorigenesis.

ATRX BRCA2

4.41e-05495228186538
Pubmed

The mouse interferon-inducible gene Ifi204 product interacts with the Tpr protein, a component of the nuclear pore complex.

TPR IFI16

4.41e-05495212513910
Pubmed

Characteristics of DNA-binding proteins determine the biological sensitivity to high-linear energy transfer radiation.

ATRX PRKDC

4.41e-05495220150414
Pubmed

Characterization of staufen1 ribonucleoproteins by mass spectrometry and biochemical analyses reveal the presence of diverse host proteins associated with human immunodeficiency virus type 1.

TPR RAN ABCE1 PTDSS1 PYGL PRKDC

5.40e-0524195623125841
Pubmed

ER-export and ARFRP1/AP-1-dependent delivery of SARS-CoV-2 Envelope to lysosomes controls late stages of viral replication.

RPL21 AP4E1 RAN STIM2 DSC2 ABCE1 PTDSS1 ABCC5 PYGL AKAP11 SLC4A4

5.87e-05952951138569033
Pubmed

SR protein kinases promote splicing of nonconsensus introns.

CUL3 ANK3 MYOM1 DSC2 PHF3 ASXL3 PRKDC

6.19e-0536195726167880
Pubmed

The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.

GATAD2A ATRX ASH1L KDM2B SMARCC2

7.34e-0515795530186101
Pubmed

Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.

RPL21 TPR ABCE1 PHF3 STRBP UTP14A SMARCC2 PYGL PRKDC

7.68e-0565395922586326
Pubmed

MYC multimers shield stalled replication forks from RNA polymerase.

RPL21 RAN RPL32 POP4 PHF3 STRBP UTP14A SMARCC2 PRKDC SRBD1 NMD3

8.24e-05989951136424410
Pubmed

New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.

RPL21 RPL32 SETMAR ASXL3 SETBP1 KDM2B PRKDC CSMD3

8.39e-0551395825798074
Pubmed

BRCA1-BARD1 promotes RAD51-mediated homologous DNA pairing.

ATRX BRCA2

1.10e-04695228976962
Pubmed

Identification and functional characterization of transcriptional activators in human cells.

GATAD2A KDM2B SMARCC2 PYGL ZNF518B PRKDC SUZ12

1.13e-0439895735016035
Pubmed

Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.

RPL32 AFAP1L2 DSC2 ATRX KALRN ASXL3 ABCC5 AKAP11

1.39e-0455295810737800
Pubmed

Ion channel expression in the developing enteric nervous system.

ANK3 KCNJ6 KCNN2

1.43e-043795325798587
Pubmed

Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event.

RAN RPL32 GATAD2A SMARCC2 PRKDC

1.47e-0418295526527279
Pubmed

ATRX In-Frame Fusion Neuroblastoma Is Sensitive to EZH2 Inhibition via Modulation of Neuronal Gene Signatures.

ATRX SUZ12

1.54e-04795231631027
Pubmed

CRL4A-FBXW5-mediated degradation of DLC1 Rho GTPase-activating protein tumor suppressor promotes non-small cell lung cancer cell growth.

CUL3 DLC1

1.54e-04795224082123
Pubmed

Mutation of ARHGAP9 in patients with coronary spastic angina.

DLC1 TIAM1 ARHGEF38

1.55e-043895319911011
Pubmed

Quantitative nanoproteomics for protein complexes (QNanoPX) related to estrogen transcriptional action.

CUL3 RAN PRKDC

1.95e-044195319805454
Pubmed

Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (Mrp) family in mice.

ABCC5 ABCC12

2.05e-04895215802388
Pubmed

Targeted and Interactome Proteomics Revealed the Role of PHD2 in Regulating BRD4 Proline Hydroxylation.

RAN RPL32 DSC2 ATRX ABCE1 PYGL PRKDC

2.13e-0444195731239290
Pubmed

The polyproline-motif of S6K2: eIF5A translational dependence and importance for protein-protein interactions.

RPL21 RPL32 ZNF90

2.41e-044495330320934
Pubmed

DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.

BRCA2 ATAD5 PHF3 TOPBP1 SMARCC2 SGO2 IFI16

2.50e-0445395729656893
Pubmed

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality.

RPL21 TPR GATAD2A ATAD5 STRBP UTP14A SMARCC2 PRKDC

2.58e-0460595828977666
Pubmed

A mechanism for the suppression of homologous recombination in G1 cells.

CUL3 BRCA2

2.62e-04995226649820
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

CUL3 TPR ATRX PHF3 KDM2B SMARCC2 PRKDC SUZ12 IFI16

2.73e-0477495915302935
Pubmed

Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.

AP4E1 RAN STIM2 ANK3 DSC2 UTP14A ABCC5 PRKDC ACVR1B

2.81e-0477795935844135
Pubmed

Transferrin Receptor Protein 1 Cooperates with mGluR2 To Mediate the Internalization of Rabies Virus and SARS-CoV-2.

RPL21 TPR PTDSS1 SMARCC2 PRKDC SRBD1

3.13e-0433395636779763
Pubmed

Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.

RPL21 TPR RAN GATAD2A ABCE1 UTP14A SMARCC2 PYGL PRKDC SRBD1 IFI16 NMD3

3.18e-041353951229467282
Pubmed

Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages.

ATRX SUZ12

3.28e-041095236635505
Pubmed

Genome-wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations-significant evidence for linkage on chromosome 4q in African Americans: the Family Investigation of Nephropathy and Diabetes Research Group.

ZNF7 DLC1

3.28e-041095219795399
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

GATAD2A ATAD5 ABCE1 STRBP ASXL3 KDM2B SMARCC2 SIK3

3.68e-0463895831182584
Pubmed

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.

STIM2 DLC1 RIN2 PTDSS1 ANKS1B KCNN2 IFI16 C19orf18 SAMD4A

3.94e-0481495923251661
Pubmed

Modification of ovarian cancer risk by BRCA1/2-interacting genes in a multicenter cohort of BRCA1/2 mutation carriers.

BRCA2 TOPBP1

4.00e-041195219584272
Pubmed

FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16.

BRCA2 PRKDC

4.00e-041195218406329
Pubmed

CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling.

CUL3 TIAM1

4.00e-041195225684205
Pubmed

Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation.

KDM2B PRKDC

4.00e-041195226237645
Pubmed

Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations.

RHOQ RAN IGFBP3

4.19e-045395314651920
Pubmed

EVI1 oncoprotein interacts with a large and complex network of proteins and integrates signals through protein phosphorylation.

TPR RAN SMARCC2 PRKDC

4.30e-0412895423858473
Pubmed

A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

TPR GATAD2A KALRN PHF3 TOPBP1 IFI16 DENND4C

4.69e-0450395716964243
Pubmed

Intrinsically Disordered Protein TEX264 Mediates ER-phagy.

GATAD2A ABCE1 SMARCC2 AKAP11

4.69e-0413195431006538
Pubmed

Mutations in RNF135, a gene within the NF1 microdeletion region, cause phenotypic abnormalities including overgrowth.

ATAD5 SUZ12

4.79e-041295217632510
Pubmed

Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes.

BRCA2 TOPBP1

4.79e-041295216391231
Pubmed

Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.

TIAM1 KALRN ASXL3 CCDC15

5.11e-0413495424324551
Pubmed

BRCA2 mediates centrosome cohesion via an interaction with cytoplasmic dynein.

BRCA2 PYGM DCST2

5.19e-045795327433848
Pubmed

Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.

RPL21 TPR RPL32 GATAD2A PHF3 PTDSS1 SMARCC2 PRKDC IFI16

5.25e-0484795935850772
Pubmed

Two-Dimensional Fractionation Method for Proteome-Wide Cross-Linking Mass Spectrometry Analysis.

RPL21 TPR RAN GATAD2A TRO MRPL30 TOPBP1 SMARCC2 PRKDC

5.25e-0484795935235311
Pubmed

Identification and sequencing the juvenile spermatogonial depletion critical interval on mouse chromosome 1 reveals the presence of eight candidate genes.

CUL3 UTP14A

5.65e-041395211700028
Pubmed

IGFBP-3 interacts with NONO and SFPQ in PARP-dependent DNA damage repair in triple-negative breast cancer.

IGFBP3 PRKDC

5.65e-041395230725116
Pubmed

Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II.

RPL21 CUL3 RAN RPL32 PRKDC

5.66e-0424495530349055
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

RPL21 TPR GATAD2A STRBP TRO UTP14A CCDC15 SMARCC2 MXD4

5.70e-0485795925609649
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

STIM2 DLC1 DSC2 TIAM1 PHF3 AKAP11 SIK3 DENND4C SAMD4A

5.90e-0486195936931259
Pubmed

Genetic and Proteomic Interrogation of Lower Confidence Candidate Genes Reveals Signaling Networks in β-Catenin-Active Cancers.

RPL21 TPR RHOQ RAN RPL32 ABCE1 PHF3 UTP14A KDM2B SMARCC2 PRKDC

5.99e-041247951127684187
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

CUL3 AFAP1L2 GTF3A PHF3 ASH1L PYGL SIK3 SAMD4A

6.10e-0468995836543142
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

CUL3 RALGPS1 SETBP1 TOPBP1 KDM2B AKAP11 SIK3

6.32e-0452995714621295
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

RPL21 CUL3 TPR RAN RPL32 GATAD2A PHF3 UTP14A PRKDC SRBD1 IFI16

6.40e-041257951136526897
Pubmed

Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.

CUL3 ATRX PHF3 STRBP UTP14A

6.43e-0425195528077445
Pubmed

Commonly studied single-nucleotide polymorphisms and breast cancer: results from the Breast Cancer Association Consortium.

IGFBP3 BRCA2

6.58e-041495217018785
Pubmed

Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder.

PHF3 ASH1L

6.58e-041495228263302
Pubmed

Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.

RPL21 RPL32 STIM2 ANK3 DSC2 TIAM1 ATRX ATAD5 UTP14A PTDSS1 AKAP11 SIK3

7.35e-041487951233957083
Pubmed

WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.

GATAD2A ATRX ATAD5 SMARCC2 PRKDC SUZ12

7.57e-0439495627248496
Pubmed

Localization of the muscle, liver, and brain glycogen phosphorylase genes on linkage maps of mouse chromosomes 19, 12, and 2, respectively.

PYGL PYGM

7.57e-04159522575583
Pubmed

Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage.

RPL21 RPL32 BRCA2 TOPBP1

7.61e-0414995425184681
Pubmed

A Network of Conserved Synthetic Lethal Interactions for Exploration of Precision Cancer Therapy.

BRCA2 ATAD5 CDC7

7.63e-046595327453043
Pubmed

UM171 Preserves Epigenetic Marks that Are Reduced in Ex Vivo Culture of Human HSCs via Potentiation of the CLR3-KBTBD4 Complex.

RPL21 CUL3 TPR PYGM PRKDC

8.48e-0426795533417871
Pubmed

Characterization of human colon cancer antigens recognized by autologous antibodies.

UTP14A USH1C

8.64e-04169529610721
Pubmed

Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications.

BRCA2 TOPBP1

8.64e-041695227760317
Pubmed

Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.

RPL21 TPR RAN STRBP SMARCC2

9.06e-0427195532433965
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

CUL3 RPL32 ANK3 TIAM1 ATRX PTDSS1 DACT3 PYGL USH1C DENND4C CDC7

9.60e-041321951127173435
Pubmed

MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair.

TPR PRKDC

9.78e-041795220479123
InteractionH2BC8 interactions

CUL3 GATAD2A ATRX ATAD5 PHF3 UTP14A TOPBP1 KDM2B SMARCC2 SGO2 AKAP11 SUZ12 SRBD1

3.03e-065769513int:H2BC8
InteractionUHRF2 interactions

CUL3 TPR ATRX PHF3 UTP14A SGO2 PRKDC SUZ12

4.75e-06200958int:UHRF2
InteractionCBX3 interactions

CUL3 ZNF567 RAN ATRX ATAD5 ABCE1 PHF3 UTP14A TOPBP1 KDM2B ZNF518B SUZ12 IFI16

1.04e-056469513int:CBX3
InteractionH3-3A interactions

CUL3 ZNF567 GATAD2A TIAM1 ATRX ATAD5 PHF3 ASH1L TOPBP1 KDM2B SMARCC2 PRKDC SUZ12 SRBD1

1.07e-057499514int:H3-3A
InteractionH1-2 interactions

CUL3 RAN RHBDL2 ATRX ABCE1 PHF3 STRBP ASXL3 TOPBP1 AKAP11 PRKDC SUZ12 IFI16

1.44e-056669513int:H1-2
InteractionRAD9A interactions

SETMAR ATRX BRCA2 ATAD5 TOPBP1

1.49e-0566955int:RAD9A
InteractionPOLR1G interactions

POP4 GATAD2A FAM32A ATAD5 PHF3 STRBP UTP14A TOPBP1 KDM2B SMARCC2 SGO2

1.91e-054899511int:POLR1G
InteractionH2BC21 interactions

CUL3 GATAD2A ATRX ATAD5 PHF3 SMARCC2 SGO2 AKAP11 ZNF518B PRKDC SUZ12 SRBD1 IFI16

2.29e-056969513int:H2BC21
InteractionCSNK2A1 interactions

RPL21 CUL3 IGFBP3 GATAD2A ATRX ATAD5 ABCE1 ASXL3 UTP14A KDM2B SMARCC2 PRKDC SRBD1 IFI16 NMD3

3.91e-059569515int:CSNK2A1
InteractionH2BC9 interactions

RPL21 RAN ATRX TRO SETBP1 ASH1L SMARCC2 AKAP11 TEX15 USH1C

4.81e-054469510int:H2BC9
InteractionZNF330 interactions

CUL3 GATAD2A ATAD5 PHF3 UTP14A TOPBP1 KDM2B SMARCC2 SUZ12 SRBD1

4.81e-054469510int:ZNF330
InteractionDCST2 interactions

BRCA2 DCST2

6.58e-053952int:DCST2
InteractionH3C1 interactions

TPR RAN RPL32 GATAD2A ANK3 ATRX ATAD5 PHF3 ASH1L KDM2B SMARCC2 PRKDC SUZ12 SRBD1

8.08e-059019514int:H3C1
InteractionNUP107 interactions

CUL3 TPR RAN SIGLECL1 PRKDC SUZ12 IFI16

8.46e-05221957int:NUP107
InteractionH3C3 interactions

GATAD2A ATRX ATAD5 PHF3 TOPBP1 KDM2B SMARCC2 SGO2 SUZ12 SRBD1

1.14e-044959510int:H3C3
CytobandEnsembl 112 genes in cytogenetic band chr18q12

DSC2 ASXL3 SETBP1 SYT4

6.75e-05104954chr18q12
Cytoband1q22

ASH1L DCST2 IFI16

2.32e-04579531q22
CytobandXq26.1

DENND10P1 UTP14A

4.99e-0416952Xq26.1
GeneFamilyGlycogen phosphorylases

PYGL PYGM

3.81e-053652437
GeneFamilyATP binding cassette subfamily C

ABCC5 ABCC12

9.68e-0413652807
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

TIAM1 KALRN ARHGEF38

1.73e-0366653722
GeneFamilySterile alpha motif domain containing

STIM2 ANKS1B SAMD4A

3.91e-0388653760
GeneFamilyPHD finger proteins

PHF3 ASH1L KDM2B

4.17e-039065388
CoexpressionCHICAS_RB1_TARGETS_GROWING

TPR OXTR IGFBP3 ATRX KCNN2 SGO2 PYGL IFI16 CDC7

2.48e-07242959M2128
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HGABA

STIM2 ANK3 ATRX ASXL3 RALGPS1 DACT3 ANKS1B KDM2B ABCC5 SMARCC2 OPN5 SYT4 ACVR1B SIK3 CSMD3

1.02e-0511069515M39071
CoexpressionGREGORY_SYNTHETIC_LETHAL_WITH_IMATINIB

RPL21 SETMAR ANK3 PYROXD1 UTP14A IFI16

1.50e-05145956M2137
CoexpressionMANNO_MIDBRAIN_NEUROTYPES_HDA1

GSDME ANK3 KALRN ASXL3 RALGPS1 KCNJ6 OPN5 SYT4 SLC4A4 CSMD3

5.16e-055849510M39068
CoexpressionGSE13547_CTRL_VS_ANTI_IGM_STIM_BCELL_2H_UP

ANK3 TIGIT BRCA2 ATAD5 SGO2 IFI16

5.54e-05183956M2993
CoexpressionDACOSTA_UV_RESPONSE_VIA_ERCC3_DN

DLC1 TIAM1 ATRX BRCA2 ABCE1 PHF3 RIN2 TOPBP1 AKAP11 SUZ12 SIK3 SAMD4A

6.20e-058569512M4500
CoexpressionENK_UV_RESPONSE_KERATINOCYTE_DN

TPR GSDME ATRX PYROXD1 ABCE1 ABCC5 AKAP11 PRKDC CDC7

6.37e-05481959M3898
CoexpressionPUJANA_BRCA_CENTERED_NETWORK

BRCA2 TOPBP1 PRKDC SUZ12 CDC7

7.12e-05118955M15305
CoexpressionGSE5679_CTRL_VS_RARA_AGONIST_AM580_TREATED_DC_UP

RAN GTF3A UTP14A SGO2 TSSK3 SRBD1

9.05e-05200956M6555
CoexpressionGSE19198_CTRL_VS_IL21_TREATED_TCELL_24H_DN

ZNF7 IGFBP3 TIAM1 CCR9 MXD4 CDC7

9.05e-05200956M7231
CoexpressionAtlasfacebase_RNAseq_e10.5_MandArch_2500_K1

ZNF7 CUL3 TPR POP4 GSDME ANK3 TIGIT ATRX BRCA2 ATAD5 STRBP ASXL3 SGO2 CPA2 ZNF518B SUZ12 SLC4A4 NMD3 CDC7

1.75e-0612419419facebase_RNAseq_e10.5_MandArch_2500_K1
CoexpressionAtlasFacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_500

ZNF7 CUL3 TPR POP4 GSDME GTF3A BRCA2 ASXL3 SGO2 CPA2 SUZ12

1.13e-054929411Facebase_RNAseq_e10.5_Mandibular Arch_500
CoexpressionAtlasFacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_500_k-means-cluster#5

ZNF7 CUL3 TPR GSDME BRCA2 SGO2 SUZ12

1.90e-05186947Facebase_RNAseq_e10.5_Mandibular Arch_500_K5
CoexpressionAtlasfacebase_RNAseq_e10.5_MandArch_2500

ZNF7 CUL3 TPR POP4 GSDME ANK3 TIGIT ATRX BRCA2 ATAD5 STRBP ASXL3 SGO2 CPA2 ZNF518B SUZ12 SLC4A4 NMD3 CDC7

1.96e-0514689419facebase_RNAseq_e10.5_MandArch_2500
CoexpressionAtlasFacebaseRNAseq_e8.5_Hind Brain Neural Epithelium_top-relative-expression-ranked_2500_k-means-cluster#3

ZNF7 CUL3 POP4 BRCA2 ATAD5 PHF3 UTP14A SGO2 ZNF518B PRKDC SUZ12

2.33e-055329411Facebase_RNAseq_e8.5_Hind Brain Neural Epithelium_2500_K3
CoexpressionAtlasfacebase_RNAseq_e10.5_Emin_LatNas_2500_K3

ZNF7 CUL3 TPR POP4 DENND10 TIGIT ATRX BRCA2 PYROXD1 ATAD5 PHF3 STRBP SETBP1 SGO2 ZNF518B SUZ12 NMD3

3.32e-0512579417facebase_RNAseq_e10.5_Emin_LatNas_2500_K3
CoexpressionAtlasfacebase_RNAseq_e10.5_Emin_LatNas_2500

ZNF7 CUL3 TPR POP4 DENND10 TIGIT ATRX BRCA2 PYROXD1 ATAD5 PHF3 STRBP SETBP1 ANKS1B SGO2 ZNF518B SUZ12 NMD3

6.29e-0514599418facebase_RNAseq_e10.5_Emin_LatNas_2500
CoexpressionAtlasFacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_1000_k-means-cluster#5

ZNF7 TPR POP4 GSDME GTF3A BRCA2 ASXL3 SGO2

1.11e-04331948Facebase_RNAseq_e10.5_Mandibular Arch_1000_K5
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_500_k-means-cluster#3

ATRX BRCA2 ATAD5 STRBP UTP14A PRKDC

2.13e-04192946Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_500_K3
CoexpressionAtlasDevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k-means-cluster#3_top-relative-expression-ranked_1000

TPR DLC1 ANK3 ATRX PHF3 SERAC1 ZNF518B SLC4A4

2.34e-04369948DevelopingLowerUrinaryTract_e14.5_ urethra_emap-30902_k3_1000
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TPR DSC2 ATRX PHF3 STRBP ASH1L AKAP11 SLC4A4

7.42e-0919194860c986d2dcbc19d9338c03da6cb5e1d92fd48f8e
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TPR DSC2 ATRX PHF3 STRBP ASH1L AKAP11 SLC4A4

7.42e-0919194809db184cb90fe282a14474d7217068c58092c6f8
ToppCelldroplet-Large_Intestine-COLON_PROXIMAL-30m|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

TPR DSC2 ATRX PHF3 STRBP ASH1L AKAP11 SLC4A4

7.42e-09191948973117730d6ba5f127e7a0bfabfd0ff2ca7ac131
ToppCelldroplet-Kidney-nan-18m-Epithelial-kidney_mesangial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

DLC1 MYOM1 DACT3 PYGM CSMD3 SAMD4A

2.95e-06188946d1a4cd4db95d8d32b79156290f7867f32824cc87
ToppCellPCW_13-14-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung

BRCA2 ATAD5 TOPBP1 CCDC15 PRKDC CDC7

3.75e-06196946df366d76ea55f49e349d622effa57c1535df8400
ToppCellMS-IIF-Lymphocyte-T/NK-Treg|IIF / Disease, condition lineage and cell class

RPL21 TPR RPL32 TIGIT KALRN ZNF90

3.97e-061989467bbf8403ecf9f8e403b04f18d265ece977cc49e7
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ANK3 KALRN STRBP SETBP1 ANKS1B CSMD3

3.97e-061989460ff30edfd3c133a42e8cb96e1631a1143215f808
ToppCellNeuronal|World / cells hierarchy compared to all cells using T-Statistic

ANK3 KALRN STRBP SETBP1 ANKS1B CSMD3

4.21e-0620094648d801219bc771d6c7e151dc88ca4c179988de85
ToppCellCOVID_vent-Lymphocytic-Proliferative_Lymphocyte-|COVID_vent / Disease condition, Lineage, Cell class and subclass

BRCA2 ATAD5 TOPBP1 SGO2 PRKDC CDC7

4.21e-062009467e4c0db43a03ca11380a54f44a3cf1991e055b80
ToppCellCOVID_vent-Lymphocytic-Proliferative_Lymphocyte|COVID_vent / Disease condition, Lineage, Cell class and subclass

BRCA2 ATAD5 TOPBP1 SGO2 PRKDC CDC7

4.21e-062009469775ca7dedb76fcbb74f80f86b33c94e394c320a
ToppCelldroplet-Large_Intestine-COLON_-_"PROM_Tm"-30m-Epithelial-Lgr5+_undifferentiated_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPL21 RPL32 ASXL3 PYGL CPA2

1.15e-05139945c300f953ff9c5e820ff16bcd9942d279b37b79db
ToppCelldroplet-Large_Intestine-COLON_-_"PROM_Tm"-30m-Epithelial-intestinal_crypt_stem_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPL21 RPL32 ASXL3 PYGL CPA2

1.15e-0513994595b19d7459d9b54162cf01d278462245d34802d5
ToppCellrenal_medulla_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

AP4E1 POP4 TIAM1 TSSK3 CSMD3

1.61e-0514994561d84838a841ed2d6b8c5f86d423a4e6b3dcc9cb
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lect1_Oxtr|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

OXTR TIAM1 PYGM CSMD3 GRPR

1.95e-0515594599e749f7075e2c64e9a0bf91009f95b6969197c8
ToppCellfacs-Spleen-nan-24m-Myeloid|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GSDME RIN2 PYGL TEX15 USH1C

2.01e-05156945034d4359359a44c205c6931f38a375271ac2752b
ToppCellfacs-Spleen-nan-24m-Myeloid-nan|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GSDME RIN2 PYGL TEX15 USH1C

2.01e-051569452a4dac4100c0339aad4905b8eaca6e8fe806718b
ToppCellfacs-Spleen-nan-24m-Myeloid-granulocyte|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GSDME RIN2 PYGL TEX15 USH1C

2.01e-0515694521267718d3a3dc19988663b6846aed8bb3eae836
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Pygm_C1ql1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TIAM1 SYTL5 KCNN2 CSMD3 GRPR

2.34e-051619453b5d7a3dab479c6959a428f3954dedd989900276
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Crispld2_Htr2c|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

OXTR SYTL5 PYGM CSMD3 GRPR

2.63e-05165945c6b23013d77fa9aa967b76e451c8e42b0a657c30
ToppCellControl|World / group, cell type (main and fine annotations)

NTN4 DLC1 ANK3 ANKS1B SLC4A4

2.87e-05168945a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCellIIF-Lymphocyte-T_NK-Treg|IIF / Disease, Lineage and Cell Type

RPL21 TPR RPL32 TIGIT KALRN

2.95e-05169945aac6ff89e0b3bc1f644e6cc6a696360659b254b5
ToppCellPND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ANK3 ATAD5 ASXL3 ARHGEF38 TEX15

3.04e-051709454ce81608111b9ee7cb974dad2c182f38db3dcd79
ToppCelldroplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_A_cell|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

OXTR ATRX SYTL5 ANKS1B ABCC12

3.68e-05177945426a9845df7fd13b02e744532c336c60bc4d4a22
ToppCellPBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c03-MKI67|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)

GRID2IP BRCA2 ATAD5 SGO2 ITGAD

3.78e-05178945dbde3305e0c6a81593fe614e3f2e746b32cc16a7
ToppCellControl-Epithelial_cells-AT2|Control / group, cell type (main and fine annotations)

NTN4 DLC1 ANK3 ARHGEF38 SLC4A4

3.99e-05180945198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

NTN4 DLC1 ANK3 ARHGEF38 SLC4A4

4.32e-051839456847c1252d6bb105524f812658112517fd351eab
ToppCelldroplet-Limb_Muscle-nan-21m-Macroglial|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AFAP1L2 ANK3 ANKS1B SYT4 CSMD3

4.54e-051859453d1353dbcb60e2531ef67e1bd218b7bc4d7c7c9b
ToppCelldroplet-Limb_Muscle-nan-21m-Macroglial-Schwann_cell|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

AFAP1L2 ANK3 ANKS1B SYT4 CSMD3

4.54e-05185945995a8ddc3fd8e6879d8b5de8cbdefe232d34833b
ToppCelldroplet-Spleen-nan-3m|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RPL21 TPR RPL32 ATRX CCR9

4.66e-0518694526f1e9930adf2fe4af0819e56f69915bd8330e4a
ToppCellControl-Epithelial_cells|Control / group, cell type (main and fine annotations)

NTN4 DLC1 ANK3 ARHGEF38 SLC4A4

4.91e-05188945707ebf76cc6fb600b2f07793cf4ea9482c0de79d
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D231|Adult / Lineage, Cell type, age group and donor

NTN4 DLC1 ANK3 ARHGEF38 SLC4A4

5.03e-05189945dab54a52358f66a8a9460cd6089a06c5fa7e7a5d
ToppCellCOVID-19-Heart-CM_4|Heart / Disease (COVID-19 only), tissue and cell type

RHBDL2 ANK3 PTDSS1 ABCC5 SLC4A4

5.16e-051909453729648a17093b438398b82e32bbccc3af7b8c5d
ToppCellDividing_Macrophages-HP_01|World / lung cells shred on cell class, cell subclass, sample id

ATRX BRCA2 ATAD5 CCDC15 SGO2

5.29e-051919453e567ed6b5fefafa7f460e49d25d60bb52a0a6c8
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2|Children_(3_yrs) / Lineage, Cell type, age group and donor

NTN4 DLC1 ANK3 ARHGEF38 SLC4A4

5.29e-05191945a0332a4ef629510fb313ec119195c44a3f704a80
ToppCelldroplet-Heart-4Chambers-21m-Mesenchymal-cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANK3 MYOM1 DSC2 KCNN2 PYGM

5.29e-05191945c172c9e17b893b290e4aa8af5e5e4cd3e4818372
ToppCelldroplet-Heart-4Chambers-21m-Mesenchymal-atrial_cardiomyocyte|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ANK3 MYOM1 DSC2 KCNN2 PYGM

5.29e-05191945715f5b449b8e075959c05a5b38389df319663164
ToppCellEpithelial-alveolar_epithelial_cell_type_2|World / Lineage, Cell type, age group and donor

NTN4 DLC1 ANK3 ARHGEF38 SLC4A4

5.42e-0519294558c3737be7acce39fd2b91d70d6d7b2bbaa4f710
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NTN4 DLC1 ANK3 ARHGEF38 SLC4A4

5.42e-05192945fb2f0e897228f808d9ff734ad05e9b49dc38fa50
ToppCellrenal_cortex_nuclei|World / Celltypes from Cells and Nuclei per compartment and clinical group

ANK3 SETBP1 ASH1L SIK3 SLC4A4

5.42e-05192945e8cc4d08fcfceeab75a02558817e4ccd7dbafe3a
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NTN4 DLC1 ANK3 ARHGEF38 SLC4A4

5.56e-05193945fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCellILEUM-inflamed-(1)_T_cell-(1)_TFH-like|(1)_T_cell / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

RPL21 RPL32 TIGIT TIAM1 IFI16

5.56e-0519394588cc740dd216ea80605b857c27914a8bc6ba6771
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2|Adult / Lineage, Cell type, age group and donor

NTN4 DLC1 ANK3 ARHGEF38 SLC4A4

5.56e-05193945738f4f0a9ddde2432b429ab46838e353b1790589
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NTN4 DLC1 ANK3 ARHGEF38 SLC4A4

5.56e-05193945f3cc7cfdbc164a4ed42f87647111522b7d393bcb
ToppCellnucseq-Epithelial-Epithelial_Alveolar|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

NTN4 DLC1 ANK3 ARHGEF38 SLC4A4

5.69e-0519494553f3e49e91b1096f3226010e2de767efb490dfe4
ToppCellChildren_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

NTN4 DLC1 ANK3 ARHGEF38 SLC4A4

5.69e-0519494597534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCellPCW_10-12-Mesenchymal-Mesenchymal_cycling-mes_proliferating1_(3)|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung

BRCA2 ATAD5 CCDC15 PRKDC CDC7

5.83e-05195945cec7df321f372d05c94f97d6bb18891a5cc3dec3
ToppCell3'-Child04-06-SmallIntestine-Hematopoietic-T_cells-Tfh|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RPL21 RPL32 TIGIT TIAM1 ANKS1B

5.83e-05195945b2ecab35db438c82872cd16a6e9f013475e559ef
ToppCellMid-temporal_gyrus_(MTG)-Neuronal|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KALRN STRBP SETBP1 ANKS1B CSMD3

5.98e-05196945676c56b44ac29f7baecb62f49bb8597cc74c0a88
ToppCellsaliva-Severe-critical_progression_d28-40-Lymphocytic|Severe-critical_progression_d28-40 / Compartment, severity and other cell annotations on 10x 3' data (130k)

RAN STIM2 TIGIT SETBP1 MXD4

5.98e-05196945c9fb81a0578db6d278b8582d7b3add6c407e6dcf
ToppCell10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-T_lymphocytic-CD4-positive,_alpha-beta_memory_T_cell|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

RPL21 RPL32 TARS3 ANK3 TIAM1

5.98e-05196945b10810c6a2ad3d3b968bfef46a68a38e0ce31331
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NTN4 ANK3 STRBP RALGPS1 ARHGEF38

5.98e-051969456ce74aa3f0ce3ca284b67e5a4660ffd2cc9611e0
ToppCellhealthy_donor-Lymphocytic-T_cell-Gamma_Delta_T_cell|healthy_donor / Disease condition, Lineage, Cell class and subclass

RPL21 NTN4 RPL32 IGFBP3 ANK3

5.98e-051969456eabbac1625f715531bae562a28da27664572600
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-T_lymphocytic-CD4-positive,_alpha-beta_T_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

RPL21 RPL32 TARS3 CCR9 SIK3

5.98e-05196945c647ce58de4c5bb4ceb1123690e637eae4ae1b82
ToppCell5'-Adult-LymphNode-Hematopoietic-T_cells-Treg|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RPL21 RPL32 TIGIT TIAM1 CCR9

6.12e-05197945a6eba89bb3e24ae973068f85a8bcc3094e985cb9
ToppCellMild|World / Condition, Lineage, Cell class and cell subclass

TPR ATRX KALRN PHF3 SMARCC2

6.12e-05197945476b0d0389f9fcd4614f6bb1f494281f467f6730
ToppCell3'-Child09-12-SmallIntestine-Hematopoietic-T_cells-Tfh|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

RPL21 RPL32 TIGIT TIAM1 ANKS1B

6.12e-05197945144ca23372b3265007a1e508e48d320581cf5695
ToppCellBrain_organoid-organoid_Kanton_Nature-Organoid-2M-Neuronal-ventral_progenitors_and_neurons_3|Organoid-2M / Sample Type, Dataset, Time_group, and Cell type.

RPL21 NTN4 RPL32 ANKS1B CSMD3

6.12e-0519794562c0682eb32a41c58d31ae33b23e7d61ce5a6abb
ToppCellsystemic_lupus_erythematosus-flare|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

TPR ATRX PHF3 ASH1L IFI16

6.27e-051989454c93ee921d56132d80832d8e94563f32ccf13bbc
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KALRN STRBP SETBP1 ANKS1B CSMD3

6.27e-05198945c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ASXL3 KCNJ6 SYT4 TEX15 USH1C

6.27e-051989458f25e8dff42bad8e779ca618bdb1cb1610667962
ToppCellprimary_auditory_cortex_(A1C)-Neuronal|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KALRN STRBP SETBP1 ANKS1B CSMD3

6.27e-051989456d18b45eda4014759e6dd282d78ffd28df8a6044
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KALRN STRBP SETBP1 ANKS1B CSMD3

6.27e-051989458ab40fae14fe02e39bc8c8da187a5cd60c787643
ToppCell356C-Lymphocytic-CD4_T-cell-CD4+_Naive_T_cell_/_CD4+_Trm_cell|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)

RPL21 RAN RPL32 ANK3 ZNF90

6.27e-051989450f25a3bf2af543267b43e56064ad06dfc18c7bd7
ToppCellParenchymal-NucSeq-Epithelial-Epi_airway_neuro-secretory|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

ASXL3 KCNJ6 SYT4 TEX15 USH1C

6.27e-05198945e3e0aa3ef20b2370f5b133048510677aaa562dfa
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NTN4 DLC1 ANK3 ARHGEF38 SLC4A4

6.42e-051999458587bd98de7767a575088afbea07a1feb4516b9b
ToppCellCaecum-T_cell-Activated_CD4_T|T_cell / Region, Cell class and subclass

RPL21 RPL32 ANK3 TIAM1 ASH1L

6.42e-0519994513173cc4dcc8e856680372b0a4ad4f36afa892c1
ToppCell(02)_MMP9/10+-(2)_GFP_FOXI1|(02)_MMP9/10+ / shred by cell type by condition

RHOQ ATRX PHF3 ACVR1B IFI16

6.42e-0519994518a7f9ced4364f45b184bd529f32ef02c27779d3
ToppCellVE-CD4-naive_CD4|VE / Condition, Cell_class and T cell subcluster

RPL21 RPL32 ANK3 TIGIT TIAM1

6.42e-05199945702e72fa93f18024b02fe3aad92cc1c3b2f6eb68
ToppCellNeuron|World / Primary Cells by Cluster

RPL32 ANK3 ATRX ASXL3 SYT4

6.42e-051999451f8104fd92f04690b41d9d07ac08dc59d76bb97d
ToppCellNeuron-Postmitotic|World / Primary Cells by Cluster

RPL32 ANK3 ATRX ASXL3 SYT4

6.42e-051999451973527f8a7d4c6490d75c0d0ea153688166a08b
ToppCell(1)_T_cell-(16)_Tfh|(1)_T_cell / shred on Cell_type and subtype

RPL21 RPL32 DENND10 TIAM1 IFI16

6.58e-052009453b28137e8e69b98fde9f6ab8320cb4d1c3543ef9
ToppCellLPS_IL1RA-Endothelial-Endothelial-Gen_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

DLC1 ATRX ASH1L ZNF518B IFI16

6.58e-05200945dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
ToppCellmild|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

TPR ATRX PHF3 ASH1L IFI16

6.58e-0520094512f1685ce8f218433068e090c9d839cd5a1910bf
ToppCellSepsis-ICU-SEP-Lymphocyte-T/NK-dn_T|ICU-SEP / Disease, condition lineage and cell class

TARS3 TIGIT KALRN DACT3 CCDC15

6.58e-052009459ee3e18dc429b9c472e3e366d9bfdbb150daa369
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Sst-Sst_Rxfp1_Prdm8|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

IGFBP3 DSC2 SYTL5 OPN5

1.26e-041219442ae870f822488799cd0ad85e7f72af64e33a867f
ToppCellcontrol-B_cell|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class

RPL21 RPL32 RHBDL2 ZNF90

1.56e-0412894424abab941b4a2f89e13089d208d40ec02f0cad10
ToppCellLPS_only-Endothelial-Endothelial-FOXM1|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

BRCA2 ATAD5 SGO2 TEX15

1.86e-041349444d8f7ddad02fe76a614771e115ebb8e04623ba85
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Gpc3_Slc18a3|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TIGIT TIAM1 SYTL5 GRPR

2.03e-04137944d346086f42d8f04d3fa67fe696834284acdc7080
ToppCellControl-B_naive-11|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

RPL21 RPL32 TRO SIGLECL1

2.14e-041399442af7ad44b707d139c6f055e63d68c09b5c1bb1be
ToppCellfacs-Trachea-18m-Mesenchymal-fibroblast-fibroblast_of_trachea-tracheal_fibroblast_l28|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

TARS3 PYROXD1 SGO2 PRKDC

2.39e-04143944b4ed3855652fdf32f97cb7c18cab4f4f4c24d5c7
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Rspo1_Itga4|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TIAM1 SYTL5 CSMD3 GRPR

2.45e-041449447de962346ba9653d90dd13bb7d977fe44d200bba
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Crispld2_Htr2c|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

OXTR TIAM1 SYTL5 PYGM

2.59e-0414694447368f981180ca6a8c81a50f7f9430f12456f609
ToppCellBac-SEP-Lymphocyte-T_NK-CD8_TCM|Bac-SEP / Disease, Lineage and Cell Type

RPL21 RPL32 RHBDL2 ITGAD

2.72e-041489445814bfb5060bac455334eb50d2a7b1f01c0b6831
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Lect1_Oxtr|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

OXTR TIAM1 PYGM GRPR

2.80e-0414994410ffd0051fb027bbebc662ca602c80d89bbf99c6
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Nr2f2_(MGE-derived_cortical_interneurons--Martinotti_cells)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

ARHGEF38 OPN5 ABCC12

3.05e-0462943a20620a8869721ea62984c2022ee1b484b455824
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Sst-Inhibitory_Neuron.Gad1Gad2.Sst-Nr2f2_(MGE-derived_cortical_interneurons--Martinotti_cells)-|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

ARHGEF38 OPN5 ABCC12

3.05e-0462943ee694c06bcd924b4ddf744178ba3a99e04eed51b
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Arhgap36_Hmcn1|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TIAM1 SYTL5 CSMD3 GRPR

3.09e-041539449c6fce56300ba5053efda59a438d63a808c497c0
ToppCellSevere-B_naive-5|World / disease group and sub_cluster of B and Plasma cells(res = 0.5)

MYOM1 DACT3 PYGL ACVR1B

3.09e-0415394444572f87d403e314050ab935d2cd676c33d9c287
ToppCell3'_v3-blood-Lymphocytic_T_CD4-Tfh|blood / Manually curated celltypes from each tissue

RPL21 TARS3 ANK3 CSMD3

3.17e-041549445ff380205fa7ab97ba21f6512bc9e14c0fb320b6
ToppCellCerebellum-Macroglia-OLIGODENDROCYTE-O1-Trf|Cerebellum / BrainAtlas - Mouse McCarroll V32

FAM186A TEX15 ITGAD

3.20e-046394383e1c91f830aadaf13e13254ce30189fd434bcc9
ToppCellCerebellum-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendroyte.Trf.Il33_(Il33)-|Cerebellum / BrainAtlas - Mouse McCarroll V32

FAM186A TEX15 ITGAD

3.20e-0463943f2532b1aa117eea550f0ae0b599780c4fe621407
ToppCellCerebellum-Macroglia-OLIGODENDROCYTE-O1|Cerebellum / BrainAtlas - Mouse McCarroll V32

FAM186A TEX15 ITGAD

3.20e-04639430643435edf3280daf38c950e5bec287a9d5cb517
ToppCellCerebellum-Macroglia-OLIGODENDROCYTE-O1-Trf-Oligodendroyte.Trf.Il33_(Il33)|Cerebellum / BrainAtlas - Mouse McCarroll V32

FAM186A TEX15 ITGAD

3.20e-046394371c3afda6534401320791b714e3e2fe83094c914
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Vip-Vip_Crispld2_Kcne4|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

TIAM1 SYTL5 PYGM GRPR

3.33e-04156944896e2d958be0a5c62fb6eebad2dfb7e1ce69f3ad
ToppCell3'_v3-Lung-Lymphocytic_T_CD4/8-lo-Tgd_CRTAM|Lung / Manually curated celltypes from each tissue

AFAP1L2 TIGIT SLC4A4 ITGAD

3.41e-04157944af6eb2214340847bbab7cb209ea27cdc83b62a27
ToppCellChildren_(3_yrs)-Endothelial-endothelial_cell_of_artery-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

AFAP1L2 IGFBP3 SETBP1 TMEM132A

3.41e-04157944275a4c6fef1fff8da2bdc48e3924ad05c5e5cfc8
ToppCellSevere-B_naive-5|Severe / disease group and sub_cluster of B and Plasma cells(res = 0.5)

MYOM1 DACT3 PYGL ACVR1B

3.41e-04157944a57ee4a6febdff3ee3d1645836695e6e7c055cf8
ToppCellhuman_hepatoblastoma-Tumor_cells-T4|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)

RAN RPL32 IGFBP3 ZNF90

3.49e-0415894453afcc8132cd61bae1adbdedb83e5bac6690bc8d
ToppCellPND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD4_T-CD4_T_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

AP4E1 RAN CCR9 CDC7

3.58e-04159944a5509f0604ef0caef5ed1af83dd89c86686c73cc
ToppCellCOPD-Epithelial-PNEC|COPD / Disease state, Lineage and Cell class

ASXL3 KCNJ6 SYT4 USH1C

3.58e-041599446018124980c55190928409f3bf41d846a118954a
DrugAmpyrone [83-07-8]; Down 200; 19.6uM; PC3; HT_HG-U133A

ANK3 DSC2 ATRX ATAD5 PHF3 TEX15 ACVR1B SLC4A4

1.33e-061909584507_DN
DrugSuccimer

CUL3 RHOQ ZNF567 IGFBP3 ANK3 DSC2 ATRX BRCA2 ATAD5 ABCE1 PHF3 ASH1L TOPBP1 SUZ12 SIK3 IFI16 MXD4 CDC7

4.20e-0612649518ctd:D004113
DrugMagnetite Nanoparticles

CUL3 RHOQ ZNF567 IGFBP3 ANK3 DSC2 ATRX BRCA2 ATAD5 ABCE1 PHF3 ASH1L TOPBP1 SUZ12 SIK3 IFI16 MXD4 CDC7

6.88e-0613109518ctd:D058185
DrugSulfamethazine sodium salt [1981-58-4]; Down 200; 13.4uM; PC3; HT_HG-U133A

TPR ANK3 DSC2 TIAM1 PHF3 ARHGEF38 IFI16

1.50e-051909574322_DN
DrugMelatonin [73-31-4]; Down 200; 17.2uM; MCF7; HT_HG-U133A

TPR ANK3 PHF3 ACVR1B MXD4 DENND4C SAMD4A

1.66e-051939573293_DN
Drug1-N-Acetyl-Beta-D-Glucosamine

PYGL PYGM

1.72e-052952DB02320
Drug3,5-dimethylphenyl isocyanate

PYGL PYGM

5.15e-053952CID000521488
Drug5-ethyl-4-hydroxy-2-methyl-3(2H)-furanone

PYGL PYGM

5.15e-053952CID000093111
Drugadenosine-5'-chloromethylphosphonate

PYGL PYGM

5.15e-053952CID000191554
Drughydan

PYGL PYGM

5.15e-053952CID000008360
DrugEHMF

PYGL PYGM

5.15e-053952CID000033931
Drug5'-deoxy-5'-fluoro-5'-(methylthio)adenosine

PYGL PYGM

5.15e-053952CID000147839
Drugpyridoxal 5'-methylenephosphonate

PYGL PYGM

5.15e-053952CID003082249
DrugPlp 5'-mpa

PYGL PYGM

5.15e-053952CID003082151
Drugglucose-1,2-cyclic phosphate

PYGL PYGM

5.15e-053952CID000191723
Drug3'-FFdUrd

PYGL PYGM

5.15e-053952CID000072260
Drug2',3',4',5,5'-pentachloro-2-biphenylol

PYGL PYGM

5.15e-053952CID000119518
DrugAC1L8XK3

PYGL PYGM

5.15e-053952CID000409735
DrugN-acetyl-N'-beta-D-glucopyranosyl urea

PYGL PYGM

5.15e-053952CID000446801
DrugNSC758405

PYGL PYGM

5.15e-053952CID000003201
Drug3,5-dinitrophenyl phosphate

PYGL PYGM

5.15e-053952CID000151920
Drugriboflavin tetraacetate

PYGL PYGM

5.15e-053952CID000094186
Drugpyridoxal phosphoglucose

PYGL PYGM

5.15e-053952CID000196007
Drug2,5-dimethyl-3-furanone

PYGL PYGM

5.15e-053952CID000085730
Drug3,5-dinitrophenol

PYGL PYGM

5.15e-053952CID000011459
Druggalocitabine

PYGL PYGM

1.03e-044952CID000065950
Drug2,5-anhydro-D-mannitol 1-phosphate

PYGL PYGM

1.03e-044952CID000189134
DrugAC1LAMW2

PYGL PYGM

1.03e-044952CID000491364
DrugFdUrd-C8

PYGL PYGM

1.03e-044952CID000094262
DrugMem-CC

PYGL PYGM

1.03e-044952CID003081269
Drug5-deoxyribose-1-phosphate

PYGL PYGM

1.03e-044952CID000135786
Drugingliforib

PYGL PYGM

1.03e-044952CID006451325
Druguric acid riboside

PYGL PYGM

1.03e-044952CID000164933
Drugpseudo-dl-glucose

PYGL PYGM

1.03e-044952CID000125259
DrugBCIp4A

PYGL PYGM

1.03e-044952CID000192417
Drugpyridoxal diphosphate

PYGL PYGM

1.03e-044952CID000125696
Drug3'-chloromethotrexate

PYGL PYGM

1.03e-044952CID000097703
DrugAC1L9IMU

KCNJ6 PYGL PYGM

1.17e-0423953CID000445825
DrugFlunisolide [3385-03-3]; Down 200; 9.2uM; PC3; HT_HG-U133A

TPR DSC2 ATRX ATAD5 PHF3 ACVR1B

1.51e-041919564303_DN
DrugDiphenhydramine hydrochloride [147-24-0]; Down 200; 13.8uM; MCF7; HT_HG-U133A

DSC2 TIAM1 ATRX ATAD5 PHF3 ASH1L

1.51e-041919566020_DN
DrugCarbarsone [121-59-5]; Up 200; 15.4uM; MCF7; HT_HG-U133A

DLC1 IGFBP3 ATAD5 PHF3 ARHGEF38 KCNN2

1.60e-041939563250_UP
DrugFamprofazone [22881-35-2]; Down 200; 10.6uM; PC3; HT_HG-U133A

TPR DSC2 ATRX ATAD5 PHF3 SAMD4A

1.64e-041949564309_DN
DrugTrimipramine maleate salt [521-78-8]; Down 200; 9.8uM; MCF7; HT_HG-U133A

AP4E1 DLC1 DSC2 ATRX UTP14A GRPR

1.64e-041949564163_DN
DrugPiperacillin sodium salt [59703-84-3]; Down 200; 7.4uM; PC3; HT_HG-U133A

CUL3 TPR DSC2 ATAD5 ARHGEF38 IFI16

1.64e-041949564320_DN
DrugClebopride maleate [84370-95-6]; Up 200; 8.2uM; HL60; HT_HG-U133A

CUL3 ANK3 RIN2 SLC4A4 IFI16 GRPR

1.69e-041959561292_UP
DrugSolanine alpha [20562-02-1]; Up 200; 4.6uM; HL60; HT_HG-U133A

CUL3 DLC1 ANK3 SETBP1 TEX15 SLC4A4

1.69e-041959562152_UP
Drugheptulose-2-P

PYGL PYGM

1.71e-045952CID000124823
Drugm-anisidine

PYGL PYGM

1.71e-045952CID000010824
Drug6-FPLP

PYGL PYGM

1.71e-045952CID000146246
Druggluconohydroximo-1,5-lactone

PYGL PYGM

1.71e-045952CID009576855
Drug2-hydroxypropylphosphonate

PYGL PYGM

1.71e-045952CID000441028
DrugDHPBU

PYGL PYGM

1.71e-045952CID000125914
Drug6-FDPL

PYGL PYGM

1.71e-045952CID000129578
Drug5'-isobutylthioinosine

PYGL PYGM

1.71e-045952CID003080910
Drug3'-O-methylpyridoxal 5'-phosphate

PYGL PYGM

1.71e-045952CID003082179
DrugGlcMan

PYGL PYGM

1.71e-045952CID000152120
DrugU66985

PYGL PYGM

1.71e-045952CID000127224
Drugindirubin-5-sulphonate

PYGL PYGM

1.71e-045952CID005288641
DrugAC1O3M08

PYGL PYGM

1.71e-045952CID006331955
DrugAC1LCUXJ

PYGL PYGM

1.71e-045952CID000656425
Drug6-amino-5-bromouracil

PYGL PYGM

1.71e-045952CID000080578
Drugetafenone

PYGL PYGM

1.71e-045952CID000003275
DrugddEtUrd

PYGL PYGM

1.71e-045952CID000451452
Drug5-trifluoromethyl-2'-deoxycytidine

PYGL PYGM

1.71e-045952CID000125618
DrugApramycin [37321-09-8]; Up 200; 7.4uM; HL60; HT_HG-U133A

DLC1 ANK3 CCR9 TMEM132A TEX15 ACVR1B

1.74e-041969562914_UP
Drug2,3-bis(3'-hydroxybenzyl)butyrolactone

RHOQ NTN4 OXTR ATRX BRCA2 PYROXD1 SYTL5 TOPBP1 ABCC5 SGO2 PRKDC MXD4 CDC7

1.76e-049619513ctd:C029497
DrugNifurtimox [23256-30-6]; Up 200; 14uM; HL60; HT_HG-U133A

ANK3 PHF3 RIN2 UTP14A ACVR1B SAMD4A

1.78e-041979562908_UP
DrugEpivincamine [6835-99-0]; Down 200; 11.2uM; MCF7; HT_HG-U133A

AP4E1 ATAD5 PHF3 RALGPS1 CCDC15 ACVR1B

1.83e-041989566838_DN
DrugBenzthiazide [91-33-8]; Down 200; 9.2uM; HL60; HT_HG-U133A

DLC1 ANK3 TRO UTP14A GRPR MXD4

1.83e-041989562989_DN
DrugHexylcaine hydrochloride [532-76-3]; Up 200; 13.4uM; HL60; HT_HG-U133A

DLC1 OXTR SETBP1 UTP14A TEX15 SAMD4A

1.83e-041989562708_UP
DrugBetonicine [515-25-3]; Down 200; 25.2uM; PC3; HT_HG-U133A

RALGPS1 UTP14A ASH1L ACVR1B MXD4 SAMD4A

1.83e-041989563745_DN
Drug(S)-propranolol hydrochloride [4199-10-4]; Down 200; 13.6uM; HL60; HT_HG-U133A

CUL3 ATRX UTP14A ACVR1B SLC4A4 MXD4

1.83e-041989562961_DN
DrugICI 182,780; Up 200; 0.01uM; MCF7; HT_HG-U133A

PHF3 TRO RALGPS1 GRPR MXD4 SAMD4A

1.83e-041989565598_UP
DrugQuinethazone [73-49-4]; Down 200; 13.8uM; PC3; HT_HG-U133A

DSC2 TIAM1 BRCA2 PHF3 UTP14A MXD4

1.83e-041989563793_DN
DrugFlucytosine [2022-85-7]; Down 200; 31uM; MCF7; HT_HG-U133A

IGFBP3 DSC2 PHF3 UTP14A ACVR1B GRPR

1.83e-041989566450_DN
DrugPropranolol hydrochloride [318-98-9]; Up 200; 13.6uM; HL60; HT_HG-U133A

AP4E1 OXTR ANK3 TIAM1 USH1C MXD4

1.83e-041989563059_UP
DrugXylometazoline hydrochloride [1218-35-5]; Up 200; 14.2uM; MCF7; HT_HG-U133A

CUL3 PHF3 TEX15 ACVR1B GRPR MXD4

1.88e-041999567020_UP
Drugestradiol, USP; Down 200; 0.01uM; MCF7; HT_HG-U133A

IGFBP3 DSC2 ATAD5 PHF3 ACVR1B MXD4

1.88e-041999567000_DN
DrugAdamantamine fumarate [80789-67-9]; Up 200; 9.6uM; MCF7; HT_HG-U133A

IGFBP3 DSC2 RALGPS1 UTP14A ACVR1B MXD4

1.88e-041999563280_UP
Drugvaldecoxib; Down 200; 10uM; MCF7; HT_HG-U133A

DSC2 TRO CPA2 USH1C IFI16 SAMD4A

1.88e-041999566403_DN
DrugPilocarpine

RPL32 IGFBP3 ANK3 ATRX CCR9 KCNN2 ABCC5

1.93e-04285957ctd:D010862
DrugCV-araU

PYGL PYGM

2.56e-046952CID006441877
Drug2-thiothymidine

PYGL PYGM

2.56e-046952CID003005944
DrugCarbocyclic Bvdc

PYGL PYGM

2.56e-046952CID006438602
DrugDNPP

PYGL PYGM

2.56e-046952CID000067056
Drug5-chloro-indole-2-carboxylic acid

PYGL PYGM

2.56e-046952CID000082693
Drug2,2-dimethyl-3-hydroxybutyric acid

PYGL PYGM

2.56e-046952CID000152984
DrugEdUMP

PYGL PYGM

2.56e-046952CID003085112
Drug4-hydroxyacetophenone

PYGL PYGM

2.56e-046952ctd:C031335
Drug5'-deoxy-5'-chloroformycin

PYGL PYGM

2.56e-046952CID000126430
DrugNSC-97433

PYGL PYGM

2.56e-046952CID000001803
Drug5-n-propylthioadenosine

PYGL PYGM

2.56e-046952CID000656428
DrugAzddCyd

PYGL PYGM

2.56e-046952CID000451374
Drug5-Ffdru

PYGL PYGM

2.56e-046952CID000065561
DrugAR-L57

PYGL PYGM

2.56e-046952CID000156890
DrugCarbocyclic Ivdu

PYGL PYGM

2.56e-046952CID006439191
Drugalpha-(fluoromethyl)dehydroornithine

PYGL PYGM

3.57e-047952CID006439607
Drug6-fluoropyridoxal

PYGL PYGM

3.57e-047952CID003080803
Drug2',3'-dideoxy-3'-fluorocytidine

PYGL PYGM

3.57e-047952CID000356019
Drugheptenitol

PYGL PYGM

3.57e-047952CID000188267
Diseaselevel of triacylglycerol (56:6) in blood serum

GATAD2A ZNF90 SIK3

1.59e-0516923OBA_2020007
Diseaseunipolar depression, bipolar disorder

GSDME ANK3 ASXL3 SETBP1 KDM2B

1.32e-04156925EFO_0003761, MONDO_0004985
Diseasebrain disease (implicated_via_orthology)

STIM2 TIAM1

1.43e-046922DOID:936 (implicated_via_orthology)
DiseaseNeurodevelopmental Disorders

CUL3 ASXL3 SETBP1 ASH1L

2.09e-0493924C1535926
Diseaseasparaginase-induced acute pancreatitis

CPA2 C3orf20

3.41e-049922EFO_1001507
Diseaselevel of Ceramide (d42:1) in blood serum

GATAD2A SIK3

4.26e-0410922OBA_2045187
Diseaselevel of Triacylglycerol (51:3) in blood serum

GATAD2A SIK3

4.26e-0410922OBA_2045163
Diseaseinositol measurement

SETBP1 SYT4

8.54e-0414922EFO_0010504
DiseaseMYELODYSPLASTIC SYNDROME

ATRX BRCA2 SETBP1

1.22e-0367923C3463824
DiseaseMalignant Glioma

ATRX BRCA2 SUZ12

1.38e-0370923C0555198
Diseasemixed gliomas

ATRX BRCA2 SUZ12

1.38e-0370923C0259783
DiseaseFEV/FEC ratio

NTN4 DLC1 STRBP UTP14A MRPL30 ARHGEF38 ANKS1B SYT4 SUZ12 ACVR1B GRPR

1.53e-0312289211EFO_0004713
DiseaseColorectal Carcinoma

DLC1 IGFBP3 TIAM1 KALRN ABCE1 SETBP1 ABCC5 CSMD3

1.59e-03702928C0009402
Diseaseperiodontal measurement

ASH1L IFI16

2.54e-0324922EFO_0007780
DiseaseGlioma

ATRX BRCA2 SUZ12

2.57e-0387923C0017638
DiseaseIntellectual Disability

AP4E1 SETBP1 ASH1L SMARCC2 SERAC1 SUZ12

2.78e-03447926C3714756

Protein segments in the cluster

PeptideGeneStartEntry
TKKTVSIKVRHIGLI

USH1C

156

Q9Y6N9
LIEKAKALHISRSKV

ATAD5

706

Q96QE3
ILKKVTHFSIVLTAK

DENND10P1

81

Q6NSW5
AIKTTIKHPRKALKS

ASH1L

111

Q9NR48
LAVVTHRVKKAIDFK

CSMD3

441

Q7Z407
IAHRDLKSKNILVKK

ACVR1B

331

P36896
ISKKSKRVTNHLKIL

ARHGEF38

316

Q9NXL2
RLKSSVKAVILKDSK

GSDME

461

O60443
LGSSVIHKEKQVRKK

AFAP1L2

221

Q8N4X5
LEKFIHSVIISKRSK

C19orf18

171

Q8NEA5
HSVIISKRSKNIKKK

C19orf18

176

Q8NEA5
RLSKSIIKHSIDKSK

AKAP11

941

Q9UKA4
VKSIVDFIKSHGKVK

CPA2

286

P48052
QTKVLKKRHTKEKVL

DSC2

116

Q02487
IKVKNHSVLQRTEKK

ASXL3

861

Q9C0F0
ADTVSHKFRRKSKVK

AP4E1

786

Q9UPM8
IKDRKVKAKSIVFHR

RAN

126

P62826
KIRAEILSHFVKIAK

RALGPS1

116

Q5JS13
VKKIKPKVVSRTIFH

ANKS1B

661

Q7Z6G8
QKKALKVEHTSRLKA

GATAD2A

446

Q86YP4
TLSLLKRAKVHIKKL

MXD4

91

Q14582
HIVEASIRAKLIKSK

KCNJ6

231

P48051
NTKLVKKIDHAKVRK

KCNN2

436

Q9H2S1
SIVKKCIHKATRKDV

KALRN

2696

O60229
KIIAKVKSSSKEVAH

OPN5

221

Q6U736
SSVKLISKAKIRTVK

OXTR

261

P30559
HKNGARKSAKKILIV

ITGAD

241

Q13349
SAIRKHLKSKTVLFV

ABCC5

726

O15440
ARVVKRFILHAKKTA

ABCE1

501

P61221
VRKVAETKEKSKHLK

ATRX

936

P46100
FRKKEVVEILSHKKA

GRID2IP

886

A4D2P6
RKRHAAEKQKKKTVI

KDM2B

16

Q8NHM5
VFVKIKASHALKKKI

DACT3

601

Q96B18
QKVRTSKTRKKIFHE

BRCA2

321

P51587
VLSRKLATKKKAIST

CDC7

316

O00311
RILKKASKTHKQRVE

FAM32A

76

Q9Y421
TSKLHRVKIQTVAAK

CUL3

666

Q13618
PVRKTTKIHTKAKVT

C3orf20

631

Q8ND61
HVKKQIESRKRLAKT

GRPR

251

P30550
KSSKHKALKVTITVL

CCR9

246

P51686
AKRTKQEIKTAHKLA

DENND4C

746

Q5VZ89
TVKVRKSQLKEVCKH

ANK3

3981

Q12955
SHIKVIKTRKNKKDI

IFI16

756

Q16666
VSALNKIKAIARKTK

DCST2

146

Q5T1A1
VAKKRLAIISSLKSK

FAM186A

1951

A6NE01
ILKKVTHFSIVLTAK

DENND10

81

Q8TCE6
KIIIIKKGHAKDSQR

IGFBP3

171

P17936
EKKHKVKTRVLRKTL

SYT4

201

Q9H2B2
RHTGKIKTIKIFKNS

TARS3

346

A2RTX5
SKATKHKTLVIKKSV

SYTL5

621

Q8TDW5
KKHTVKKRIGSRCIN

RHOQ

186

P17081
KELHKAVRKVLATSA

SERAC1

96

Q96JX3
KIVKKRTKKFIRHQS

RPL32

11

P62910
GKDRAKSKKVHRIVS

RHBDL2

36

Q9NX52
VNAKLKVVKHLIRIK

MRPL30

106

Q8TCC3
LTLRIKVKKGLHVTA

TMEM132A

286

Q24JP5
HVEVNVKIKKVLKST

NTN4

541

Q9HB63
TKHIFKIITKEDRLK

POP4

161

O95707
STVVRHLKQIGKVKK

SETMAR

441

Q53H47
LIVKHIRKKQAKKAA

SIGLECL1

136

Q8N7X8
KRATHLVTKAKVAIK

SIK3

81

Q9Y2K2
IKRHLKDKRISKTTK

SGO2

16

Q562F6
KKTAKLHVAVKVLQA

STRBP

436

Q96SI9
IKKTLRGKTVVLVTH

ABCC12

646

Q96J65
HEKTAKSKTRSLLKR

DLC1

656

Q96QB1
VKAKHLAAVEERKIK

SMARCC2

871

Q8TAQ2
LRAVAKKVHSTIQKI

SRBD1

271

Q8N5C6
RHRLASFKTVIKKKG

CCDC15

181

Q0P6D6
RSVVSINHKKLVKEK

ZNF567

96

Q8N184
VHKSTKMQKKVLSLR

RIN2

121

Q8WYP3
LVHKKNKKVESATRR

TIAM1

446

Q13009
VARIHSEILKKTIFK

PYGM

456

P11217
KASKARKTIAKVINT

TRO

256

Q12816
KLIAEKSEAKIAHKR

PYROXD1

196

Q8WU10
KIKKKRSTVFGTLHV

STIM2

386

Q9P246
EKTRKAIVAAKSKIA

TPR

1551

P12270
EAFSKKHQRKVAIKV

TSSK3

26

Q96PN8
VLLVKVCHKKRKDVS

SUZ12

186

Q15022
VIHSKTKVNVKSVKR

PHF3

516

Q92576
IKHSKSRDSFLKRVK

RPL21

96

P46778
RITTRHKKQLKKCSV

UTP14A

756

Q9BVJ6
VALTRKKKALRIHSV

TIGIT

161

Q495A1
RIIEKKHVSLNKAKK

PRKDC

1136

P78527
KAFKRSSVLSKHKII

ZNF90

516

Q03938
ITAVIVNRKEHKLKK

SLC4A4

801

Q9Y6R1
KVKKSREKRSLASHL

GTF3A

311

Q92664
KCLSRKLDKAVVHLK

TEX15

991

Q9BXT5
HKRKKRQSIKAVVEK

SETBP1

416

Q9Y6X0
VAKIHSDIVKTKVFK

PYGL

456

P06737
HKVVVCVSKKLSKKQ

TOPBP1

906

Q92547
KDIHTTTGKIKRAVL

PTDSS1

251

P48651
TKGARHKIVISIQKL

SAMD4A

366

Q9UPU9
FVSRKKVNTIKKLHQ

ZNF7

621

P17097
ISRNKTKQVHLSRKK

ZNF518B

886

Q9C0D4
LKCKVANIKKETHIV

MYOM1

1376

P52179
HSKRLKVKLTIQKEV

NMD3

106

Q96D46