Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionATP:phosphate antiporter activity

SLC25A25 SLC25A23

3.32e-053672GO:0140987
GeneOntologyMolecularFunctionorganophosphate:phosphate antiporter activity

SLC25A25 SLC25A23

2.30e-047672GO:0015315
DomainEnvoplakin

EVPLL EVPL

1.16e-052642IPR030460
Pubmed

Differential localization of Mox-1 and Mox-2 proteins indicates distinct roles during development.

MEOX1 MEOX2

3.88e-0626929032023
Pubmed

APP involvement in retinogenesis of mice.

PTF1A APP

3.88e-06269220978902
Pubmed

The single amphioxus Mox gene: insights into the functional evolution of Mox genes, somites, and the asymmetry of amphioxus somitogenesis.

MEOX1 MEOX2

3.88e-06269212051829
Pubmed

Loss of C. elegans BBS-7 and BBS-8 protein function results in cilia defects and compromised intraflagellar transport.

TTC8 BBS7

3.88e-06269215231740
Pubmed

Interaction between the scaffold proteins CBP by IQGAP1 provides an interface between gene expression and cytoskeletal activity.

EXOC5 EIF4G2 APP SNRNP200

1.11e-056969432238831
Pubmed

Reelin protects against amyloid β toxicity in vivo.

APP MEOX2

1.16e-05369226152694
Pubmed

Characterization of the human B cell RAG-associated gene, hBRAG, as a B cell receptor signal-enhancing glycoprotein dimer that associates with phosphorylated proteins in resting B cells.

CHST15 HCK

1.16e-05369210749872
Pubmed

Identification of the mitochondrial ATP-Mg/Pi transporter. Bacterial expression, reconstitution, functional characterization, and tissue distribution.

SLC25A25 SLC25A23

1.16e-05369215123600
Pubmed

Identification of a novel human subfamily of mitochondrial carriers with calcium-binding domains.

SLC25A25 SLC25A23

1.16e-05369215054102
Pubmed

Glucagon regulation of oxidative phosphorylation requires an increase in matrix adenine nucleotide content through Ca2+ activation of the mitochondrial ATP-Mg/Pi carrier SCaMC-3.

SLC25A25 SLC25A23

1.16e-05369223344948
Pubmed

Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors.

MEOX1 MEOX2

2.32e-05469211423130
Pubmed

BBS7 and TTC8 (BBS8) mutations play a minor role in the mutational load of Bardet-Biedl syndrome in a multiethnic population.

TTC8 BBS7

2.32e-05469219402160
Pubmed

Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21 and p16 in vascular endothelial cells.

MEOX1 MEOX2

2.32e-05469222206000
Pubmed

Lifting the lid on Pandora's box: the Bardet-Biedl syndrome.

TTC8 BBS7

2.32e-05469215917208
Pubmed

Sequence variants in four genes underlying Bardet-Biedl syndrome in consanguineous families.

TTC8 BBS7

2.32e-05469228761321
Pubmed

Transient activation of meox1 is an early component of the gene regulatory network downstream of hoxa2.

MEOX1 MEOX2

2.32e-05469221245383
Pubmed

Mox-1 and Mox-2 define a novel homeobox gene subfamily and are differentially expressed during early mesodermal patterning in mouse embryos.

MEOX1 MEOX2

2.32e-0546921363541
Pubmed

Single-domain antibody-SH3 fusions for efficient neutralization of HIV-1 Nef functions.

AP1G2 HCK

2.32e-05469222345475
Pubmed

VRK3-mediated nuclear localization of HSP70 prevents glutamate excitotoxicity-induced apoptosis and Aβ accumulation via enhancement of ERK phosphatase VHR activity.

VRK3 APP

2.32e-05469227941812
Pubmed

USP21 negatively regulates antiviral response by acting as a RIG-I deubiquitinase.

DHX58 MEOX2

3.86e-05569224493797
Pubmed

Mammalian COPII coat component SEC24C is required for embryonic development in mice.

PTF1A MEOX2

3.86e-05569224876386
Pubmed

The absence of BBSome function decreases synaptogenesis and causes ectopic synapse formation in the retina.

TTC8 BBS7

3.86e-05569232433491
Pubmed

Meox homeodomain proteins are required for Bapx1 expression in the sclerotome and activate its transcription by direct binding to its promoter.

MEOX1 MEOX2

3.86e-05569215024065
Pubmed

A dual fate of the hindlimb muscle mass: cloacal/perineal musculature develops from leg muscle cells.

MEOX1 MEOX2

5.79e-05669215653949
Pubmed

Pax1 and Pax9 activate Bapx1 to induce chondrogenic differentiation in the sclerotome.

MEOX1 MEOX2

5.79e-05669212490554
Pubmed

Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions.

IL22RA1 IL19

5.79e-05669212351624
Pubmed

Protein kinase R and the integrated stress response drive immunopathology caused by mutations in the RNA deaminase ADAR1.

DHX58 MEOX2

8.09e-05769234343497
Pubmed

Mox2 is a component of the genetic hierarchy controlling limb muscle development.

MEOX1 MEOX2

8.09e-05769210403250
Pubmed

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.

TRIM49 SF3B3 RHOBTB1 CLK2 MAP4K2 HCK

9.77e-0537269622939624
Pubmed

Dissection of epistasis in oligogenic Bardet-Biedl syndrome.

TTC8 BBS7

1.08e-04869216327777
Pubmed

NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load.

APP MEOX2

1.08e-04869234617884
Pubmed

Direct role of Bardet-Biedl syndrome proteins in transcriptional regulation.

TTC8 BBS7

1.38e-04969222302990
Pubmed

Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate for psychiatric illnesses.

TTC8 BBS7

1.38e-04969218762586
Pubmed

Ubiquitylation of BBSome is required for ciliary assembly and signaling.

TTC8 BBS7

1.38e-04969236744302
Pubmed

Congenital Hepatic Fibrosis Overview ─ RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY

TTC8 BBS7 GLIS2

1.54e-045269320301743
Pubmed

A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened.

TTC8 BBS7

1.73e-041069222072986
Pubmed

Temporal expression pattern of Bardet-Biedl syndrome genes in adipogenesis.

TTC8 BBS7

1.73e-041069217379567
Pubmed

A BBSome subunit links ciliogenesis, microtubule stability, and acetylation.

TTC8 BBS7

1.73e-041069219081074
Pubmed

A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis.

TTC8 BBS7

1.73e-041069217574030
Pubmed

Bardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals common BBS-associated phenotypes and Bbs3 unique phenotypes.

TTC8 BBS7

1.73e-041069222139371
Pubmed

High-resolution gene expression analysis of the developing mouse kidney defines novel cellular compartments within the nephron progenitor population.

ZNF462 MEOX1 MEOX2

1.92e-045669319591821
Pubmed

Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.

PDE4D HECTD4

2.11e-041169221642993
Pubmed

The centriolar satellite protein AZI1 interacts with BBS4 and regulates ciliary trafficking of the BBSome.

TTC8 BBS7

2.11e-041169224550735
Pubmed

A noncanonical PWI domain in the N-terminal helicase-associated region of the spliceosomal Brr2 protein.

SF3B3 SNRNP200

2.11e-041169225849387
Pubmed

Nephrocystin proteins NPHP5 and Cep290 regulate BBSome integrity, ciliary trafficking and cargo delivery.

TTC8 BBS7

2.11e-041169225552655
Pubmed

The SOX2-interactome in brain cancer cells identifies the requirement of MSI2 and USP9X for the growth of brain tumor cells.

PWP1 ZNF462 PPP2R5C IPO7 SCFD1

2.49e-0428269523667531
Pubmed

Fgfr1 regulates development through the combinatorial use of signaling proteins.

MEOX1 MEOX2

2.53e-041269226341559
Pubmed

WW domains provide a platform for the assembly of multiprotein networks.

SF3B3 TBC1D4 SNRNP200 CPSF7

2.56e-0415469416055720
Pubmed

The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.

SF3B3 TBC1D4 IPO7 EIF4G2 SCFD1 SNRNP200 CPSF7

2.73e-0463869733239621
Pubmed

Anterior visceral endoderm SMAD4 signaling specifies anterior embryonic patterning and head induction in mice.

MEOX1 MEOX2

2.98e-041369220941375
Pubmed

Intrinsic protein-protein interaction-mediated and chaperonin-assisted sequential assembly of stable bardet-biedl syndrome protein complex, the BBSome.

TTC8 BBS7

2.98e-041369222500027
Pubmed

Cellular substrates and pro-apoptotic function of the human HtrA4 protease.

SF3B3 IPO7 EIF4G2 SNRNP200

3.97e-0417369431470122
Pubmed

Trim43a, Trim43b, and Trim43c: Novel mouse genes expressed specifically in mouse preimplantation embryos.

TRIM49 TRIM49C

4.01e-041569219703589
Pubmed

The concerted action of Meox homeobox genes is required upstream of genetic pathways essential for the formation, patterning and differentiation of somites.

MEOX1 MEOX2

4.01e-041569212925591
Pubmed

The BBSome controls IFT assembly and turnaround in cilia.

TTC8 BBS7

4.01e-041569222922713
Pubmed

BBS6, BBS10, and BBS12 form a complex with CCT/TRiC family chaperonins and mediate BBSome assembly.

TTC8 BBS7

4.01e-041569220080638
Pubmed

Maturation of postnatally generated olfactory bulb granule cells depends on functional γ-protocadherin expression.

PCDHGB5 PCDHGB4

4.01e-041569223515096
Pubmed

Lack of the mesodermal homeodomain protein MEOX1 disrupts sclerotome polarity and leads to a remodeling of the cranio-cervical joints of the axial skeleton.

MEOX1 MEOX2

4.01e-041569219520072
Pubmed

Fat4-Dchs1 signalling controls cell proliferation in developing vertebrae.

MEOX1 MEOX2

4.57e-041669227381226
Pubmed

New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.

ZNF462 CCDC88C SF3B3 PARPBP SNRNP200 MEOX1

5.47e-0451369625798074
Pubmed

LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.

DHX58 IPO7 MTM1 EIF4G2 SNRNP200

6.15e-0434469530333137
Pubmed

FGF signaling regulates development by processes beyond canonical pathways.

MEOX1 MEOX2

6.49e-041969233184218
Pubmed

Identification of a genomic reservoir for new TRIM genes in primate genomes.

TRIM49 TRIM49C

6.49e-041969222144910
Pubmed

A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.

PWP1 TBCCD1 THOP1 IPO7 PTPRO MTM1 EVPL SNRNP200

6.79e-0497469828675297
Pubmed

BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites.

MEOX1 MEOX2

7.20e-042069216943278
Pubmed

Immunomic analysis of human sarcoma.

TBC1D4 ACTR5

7.95e-042169212601173
Pubmed

Genomic analysis of mouse retinal development.

PWP1 PPP2R5C CLK2 BBS7 ESRRB GLIS2 TONSL CPSF7

8.38e-04100669815226823
Pubmed

CRISPR/Cas9-mediated Genomic Editing of Cluap1/IFT38 Reveals a New Role in Actin Arrangement.

CCDC88C TTC8 BBS7 SCFD1

8.66e-0421369429615496
Pubmed

Large-scale mapping of human protein-protein interactions by mass spectrometry.

SF3B3 TBC1D4 VRK3 HUS1 CLK2 TONSL EIF4G2 SNRNP200 KPTN

9.59e-04128469917353931
Pubmed

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.

TBCCD1 PPP2R5C SF3B3 IPO7 PTPRO SNRNP200

9.70e-0457369628330616
Pubmed

TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.

ZNF462 SF3B3 SNRNP200 CPSF7

9.76e-0422069435785414
Pubmed

The splicing factor FUBP1 is required for the efficient splicing of oncogene MDM2 pre-mRNA.

SF3B3 IPO7

1.04e-032469224798327
Pubmed

Diverse Fgfr1 signaling pathways and endocytic trafficking regulate mesoderm development.

MEOX1 MEOX2

1.13e-032569238834239
Pubmed

Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1.

SF3B3 HCK

1.13e-032569212029088
Pubmed

An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.

TBC1D32 TTC8 EXOC5 PPP2R5C SF3B3 TBC1D4 BBS7 PTPRQ SNRNP200

1.17e-03132169927173435
Pubmed

Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.

TBC1D4 CHST15 PIP5K1C

1.21e-031056939628581
Pubmed

Structure--function relationships in HIV-1 Nef.

AP1G2 HCK

1.32e-032769211463741
Pubmed

Bardet-Biedl Syndrome Overview

TTC8 BBS7

1.32e-032769220301537
Pubmed

MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.

PWP1 ZNF462 SF3B3 PTPRO HECTD4 SNRNP200 CPSF7 IL19

1.33e-03108269838697112
Pubmed

Comprehensive proteomic analysis of the human spliceosome.

SF3B3 SNRNP200 CPSF7

1.35e-0310969312226669
Pubmed

Characterization of staufen1 ribonucleoproteins by mass spectrometry and biochemical analyses reveal the presence of diverse host proteins associated with human immunodeficiency virus type 1.

IPO7 SCFD1 SNRNP200 CPSF7

1.37e-0324169423125841
Pubmed

Interaction with protocadherin-gamma regulates the cell surface expression of protocadherin-alpha.

PCDHGB5 PCDHGB4

1.42e-032869215347688
Pubmed

Intersectin (ITSN) family of scaffolds function as molecular hubs in protein interaction networks.

CCDC88C PDE4D FCHSD1

1.42e-0311169322558309
Pubmed

Inherited genetic variant predisposes to aggressive but not indolent prostate cancer.

ZNF462 ESRRB

1.63e-033069220080650
Pubmed

Analysis of 30 genes (355 SNPS) related to energy homeostasis for association with adiposity in European-American and Yup'ik Eskimo populations.

TTC8 BBS7

1.63e-033069219077438
Pubmed

Muscle developmental defects in heterogeneous nuclear Ribonucleoprotein A1 knockout mice.

MEOX1 MEOX2

1.63e-033069228077597
Pubmed

Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.

SF3B3 TBC1D4 CLK2 SNRNP200

1.68e-0325569415324660
Pubmed

Proteomic analysis of complexes formed by human topoisomerase I.

SF3B3 SNRNP200

1.85e-033269215848144
Pubmed

Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

IPO7 EIF4G2 SCFD1 APP

1.88e-0326369412665801
Pubmed

Histone methyltransferase DOT1L coordinates AR and MYC stability in prostate cancer.

TONSL HECTD4 SNRNP200 CPSF7

1.91e-0326469432814769
CytobandEnsembl 112 genes in cytogenetic band chr11q14

TRIM49 CCDC83 TRIM49C

1.71e-03156693chr11q14
GeneFamilyEF-hand domain containing|Plakins

EVPLL EVPL

1.91e-048482939
GeneFamilyBardet-Biedl syndrome associated|BBSome

TTC8 BBS7

1.91e-0484821122
GeneFamilyProtein tyrosine phosphatases, receptor type

PTPRO PTPRQ

1.40e-0321482813
GeneFamilyBardet-Biedl syndrome associated|BBSome

TTC8 BBS7

1.40e-0321482980
DiseaseBardet-Biedl syndrome (implicated_via_orthology)

TBC1D32 TTC8 BBS7

1.91e-0611683DOID:1935 (implicated_via_orthology)
DiseaseBardet-Biedl syndrome (is_implicated_in)

TTC8 BBS7

4.68e-0414682DOID:1935 (is_implicated_in)
DiseaseBardet-Biedl syndrome 1 (disorder)

TTC8 BBS7

6.96e-0417682C2936862
DiseaseBardet-Biedl syndrome

TTC8 BBS7

7.82e-0418682cv:C0752166
Diseasemental development measurement

PCDHGB5 PCDHGB4

1.52e-0325682EFO_0008230
Diseaseglucose tolerance test

TBC1D4 MAP4K2

1.77e-0327682EFO_0004307
DiseaseCiliopathies

TTC8 BBS7 GLIS2

2.12e-03110683C4277690
Diseasediastolic blood pressure, unipolar depression

EIF4G2 HECTD4

2.18e-0330682EFO_0003761, EFO_0006336
Diseaseesophageal carcinoma

PDE4D HECTD4

2.18e-0330682EFO_0002916

Protein segments in the cluster

PeptideGeneStartEntry
YHCILEEADHLQEEY

BBS7

646

Q8IWZ6
VLQVHEHLNFQDYDN

CPED1

376

A4D0V7
LHLEETDENFHNYEF

TBC1D32

41

Q96NH3
YEVHHQKLVFFAEDV

APP

681

P05067
YLTSEAEEHHQLFDL

CLK2

441

P49760
IDQHEKEIHYLQDIF

CCDC65

161

Q8IXS2
LTYDHFHQSVQEIFE

AP1G2

761

O75843
NKQDLEAAYHITDIH

ARL9

126

Q6T311
FIYETEHHNGIAELL

PPP2R5C

211

Q13362
LYEHIHDLSLFLFND

ECT2L

806

Q008S8
LHEHSYIAEDYVEEL

ACTR5

246

Q9H9F9
QKYEDLETHLLSEQH

DBF4

301

Q9UBU7
ILHLSHENSIEDLQY

CCDC83

316

Q8IWF9
YIDQRIHELQEHIDD

PAAT

396

Q9H8K7
LLHNEDRHDDYFQER

CPSF7

441

Q8N684
NKAELLYDEENTIHH

PARPBP

371

Q9NWS1
EQLRELEAEFAHHNY

MEOX1

181

P50221
FYHVNVEIEDINDHT

PCDHGB4

116

Q9UN71
EEGIYTLNLHELHED

MAP4K2

506

Q12851
HDNYDQLEVHAAAIK

IL19

141

Q9UHD0
VNFLHHQLKGEYEEL

CCDC88C

1261

Q9P219
QHVLEFYEEIFSLAH

IPO7

646

O95373
HLYKENEGLHQFEEQ

KPTN

171

Q9Y664
LEDHYHADVAYHNNI

PDE4D

451

Q08499
REYEHFKQHELLSQE

EVPLL

221

A8MZ36
REYEHFKQHELLSQE

EVPL

266

Q92817
ELEAEFAHHNYLTRL

MEOX2

201

P50222
LLQDLVDHVNDYHVK

GLIS2

181

Q9BZE0
FYHVNVEIEDINDHT

PCDHGB5

116

Q9Y5G0
EDDHYRLNDELLHYI

HECTD4

396

Q9Y4D8
HDHVDLQVSALYALQ

EIF4G2

821

P78344
FHIHIEREENFTEYL

PTPRO

361

Q16827
QHINDHDFVDIYGLV

PTPRQ

2251

Q9UMZ3
EQAEVEFLSHQLHEY

PTF1A

46

Q7RTS3
VATNAHLDHYYQEEL

FCHSD1

216

Q86WN1
VAFQHFQELDEHISY

EXOC5

91

O00471
LYDYEAIHHEDLSFQ

HCK

86

P08631
YEDLHLEVHQTFQEL

CYP11B1

61

P15538
DALAALQDFYHREHV

DHX58

301

Q96C10
AYHSLRELFLDHNDL

ECM2

606

O94769
LEDIFHDLFYHLELQ

IL22RA1

156

Q8N6P7
EYQDEISLLLHNEGH

nan

61

Q6ZN92
HEALQDYELSQRHEE

ESRRB

371

O95718
EHQLKEHYQALQEES

CNTROB

366

Q8N137
LYQHFAEVSLHEEIL

KBTBD12

156

Q3ZCT8
LHHEEANNDIFLYEI

TRIM49

291

P0CI25
DYSLLLGVHNIDQHE

PIP5K1C

316

O60331
VHFDLLHEDVSLQYF

HUS1

261

O60921
EVLSYLELAQFHNAH

RHOBTB1

596

O94844
EDYLDLFDLAAHQIH

CHST15

311

Q7LFX5
QLDFEEFVHYLQDHE

SLC25A25

66

Q6KCM7
QEEDSFYVHHDILLS

PWP1

171

Q13610
EDHITQLHEYNDIKD

SWI5

191

Q1ZZU3
SHHFEDADNIYIFLE

PLK3

126

Q9H4B4
LAKALFEYIFHHEND

TTC8

191

Q8TAM2
LHENYHRETNENDIA

TMPRSS11F

281

Q6ZWK6
YHNAELFFLDIHNIH

MTM1

301

Q13496
EDYPAALQHQHQYLE

TONSL

81

Q96HA7
LHHEEANSDIFLYEI

TRIM49C

291

P0CI26
TDHYHAQPLEDNLFE

UBE2J1

26

Q9Y385
TYQALVHDVLDFHLN

SCFD1

276

Q8WVM8
LDALEFLHENEYVHG

VRK3

291

Q8IV63
HYLYQIAHLGDDDEE

SF3B3

356

Q15393
QLHAYEVEYHVLQDE

TBC1D4

1171

O60343
EDVDSEVILHHEYFL

SNRNP200

1226

O75643
YEDLKAHIQDVHTAF

ZNF462

16

Q96JM2
HFLLHSLENVEDVLY

SLC25A23

141

Q9BV35
HQAFVYDHLSDLLEL

TBCCD1

171

Q9NVR7
DGHIDFHEYLLLVFQ

RPTN

66

Q6XPR3
SLLQHDEVETYFHEF

THOP1

461

P52888
FQQLQLERHEYAEHL

GOLGA8IP

231

A6NC78