Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC28A1 ABCA1 SLC11A2 SLC24A2 ABCA12 ATP2B3 SLC25A31	8.79e-05	477	45	7	GO:0022804
GeneOntologyBiologicalProcess	response to manganese ion	SLC11A2 SLFN14 ADAM9	1.26e-05	21	45	3	GO:0010042
MousePheno	abnormal cellular cholesterol metabolism	P2RY13 ABCA1 ABCA12	1.03e-05	19	32	3	MP:0003191
MousePheno	microcytosis	SLC11A2 SLFN14 PRDX1	1.63e-05	22	32	3	MP:0002813
MousePheno	reticulocytosis	SLC28A1 SLC11A2 TIPARP PRDX1	3.17e-05	80	32	4	MP:0002640
MousePheno	abnormal reticulocyte cell number	SLC28A1 SLC11A2 TIPARP PRDX1	5.26e-05	91	32	4	MP:0011913
MousePheno	abnormal reticulocyte morphology	SLC28A1 SLC11A2 TIPARP PRDX1	6.48e-05	96	32	4	MP:0002424
MousePheno	decreased cholesterol efflux	ABCA1 ABCA12	1.81e-04	9	32	2	MP:0003193
Domain	K_chnl_volt-dep_Kv1	KCNA1 KCNA4	1.51e-04	8	44	2	IPR003972
Domain	ABC_A	ABCA1 ABCA12	3.53e-04	12	44	2	IPR026082
Domain	K_chnl_volt-dep_Kv	KCNA1 KCNA4	1.83e-03	27	44	2	IPR003968
Domain	VG_K_chnl	KCNA1 KCNA4	2.73e-03	33	44	2	IPR028325
Domain	ABC_transporter_CS	ABCA1 ABCA12	4.40e-03	42	44	2	IPR017871
Domain	ABC_TRANSPORTER_2	ABCA1 ABCA12	5.71e-03	48	44	2	PS50893
Domain	ABC_tran	ABCA1 ABCA12	5.71e-03	48	44	2	PF00005
Domain	ABC_TRANSPORTER_1	ABCA1 ABCA12	5.95e-03	49	44	2	PS00211
Domain	ABC_transporter-like	ABCA1 ABCA12	6.18e-03	50	44	2	IPR003439
Domain	BTB_2	KCNA1 KCNA4	6.93e-03	53	44	2	PF02214
Domain	T1-type_BTB	KCNA1 KCNA4	6.93e-03	53	44	2	IPR003131
Domain	Channel_four-helix_dom	KCNA1 KCNA4	7.97e-03	57	44	2	IPR027359
Domain	-	KCNA1 KCNA4	7.97e-03	57	44	2	1.20.120.350
Domain	Olfact_rcpt	OR7G1 OR4B1 OR4X2 OR2AP1	1.35e-02	393	44	4	IPR000725
Pubmed	Disinactivation of N-type inactivation of voltage-gated K channels by an erbstatin analogue.	KCNA1 KCNA4	1.64e-06	2	45	2	15136567
Pubmed	Episodic ataxia type 1 mutations affect fast inactivation of K+ channels by a reduction in either subunit surface expression or affinity for inactivation domain.	KCNA1 KCNA4	1.64e-06	2	45	2	21307345
Pubmed	Potassium channel regulator KCNRG regulates surface expression of Shaker-type potassium channels.	KCNA1 KCNA4	4.91e-06	3	45	2	19968958
Pubmed	Human potassium channel genes: Molecular cloning and functional expression.	KCNA1 KCNA4	4.91e-06	3	45	2	19912772
Pubmed	Mutations in the KCNA1 gene associated with episodic ataxia type-1 syndrome impair heteromeric voltage-gated K(+) channel function.	KCNA1 KCNA4	4.91e-06	3	45	2	10428758
Pubmed	ABCA12 regulates ABCA1-dependent cholesterol efflux from macrophages and the development of atherosclerosis.	ABCA1 ABCA12	9.81e-06	4	45	2	23931754
Pubmed	Adenylate cyclase 5 coordinates the action of ADP, P2Y1, P2Y13 and ATP-gated P2X7 receptors on axonal elongation.	P2RY13 ADCY5	9.81e-06	4	45	2	22250198
Pubmed	Subunit composition of Kv1 channels in human CNS.	KCNA1 KCNA4	1.63e-05	5	45	2	10428084
Pubmed	Differential K+ channel clustering activity of PSD-95 and SAP97, two related membrane-associated putative guanylate kinases.	KCNA1 KCNA4	2.45e-05	6	45	2	8938729
Pubmed	Truncation of the Shaker-like voltage-gated potassium channel, Kv1.1, causes megencephaly.	KCNA1 KCNA4	2.45e-05	6	45	2	14686897
Pubmed	Pore size matters for potassium channel conductance.	KCNA1 KCNA4	3.42e-05	7	45	2	27619418
Pubmed	Postsynaptic density-93 clusters Kv1 channels at axon initial segments independently of Caspr2.	KCNA1 KCNA4	3.42e-05	7	45	2	18509034
Pubmed	Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases.	KCNA1 KCNA4	3.42e-05	7	45	2	7477295
Pubmed	Heteromultimeric delayed-rectifier K+ channels in schwann cells: developmental expression and role in cell proliferation.	KCNA1 KCNA4	3.42e-05	7	45	2	9852577
Pubmed	Endogenous β-glucocerebrosidase activity in Abca12⁻/⁻epidermis elevates ceramide levels after topical lipid application but does not restore barrier function.	ABCA1 ABCA12	4.56e-05	8	45	2	24293640
Pubmed	N-terminal PDZ-binding domain in Kv1 potassium channels.	KCNA1 KCNA4	4.56e-05	8	45	2	12435606
Pubmed	ABCA12 regulates insulin secretion from β-cells.	ABCA1 ABCA12	7.32e-05	10	45	2	32072744
Pubmed	Developmental expression of voltage-sensitive K+ channels in mouse skeletal muscle and C2C12 cells.	KCNA1 KCNA4	7.32e-05	10	45	2	1383027
Pubmed	Genomic organization, nucleotide sequence, biophysical properties, and localization of the voltage-gated K+ channel gene KCNA4/Kv1.4 to mouse chromosome 2/human 11p14 and mapping of KCNC1/Kv3.1 to mouse 7/human 11p14.3-p15.2 and KCNA1/Kv1.1 to human 12p13.	KCNA1 KCNA4	8.94e-05	11	45	2	8020965
Pubmed	Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102.	KCNA1 KCNA4	1.07e-04	12	45	2	11937501
Pubmed	Odorant and vomeronasal receptor genes in two mouse genome assemblies.	OR7G1 OR4B1 OR4X2	1.23e-04	74	45	3	15081110
Pubmed	Tissue distribution, ontogeny, and hormonal regulation of xenobiotic transporters in mouse kidneys.	SLC28A1 ABCA1	1.94e-04	16	45	2	19679677
Pubmed	PNPLA1 defects in patients with autosomal recessive congenital ichthyosis and KO mice sustain PNPLA1 irreplaceable function in epidermal omega-O-acylceramide synthesis and skin permeability barrier.	CERS2 ABCA12	2.76e-04	19	45	2	28369476
Pubmed	Long-term potentiation modulates synaptic phosphorylation networks and reshapes the structure of the postsynaptic interactome.	KCNA1 KCNA4 ADAM9 PRDX1	3.13e-04	251	45	4	27507650
Pubmed	Chromosomal mapping in the mouse of eight K(+)-channel genes representing the four Shaker-like subfamilies Shaker, Shab, Shaw, and Shal.	KCNA1 KCNA4	5.22e-04	26	45	2	7905852
Pubmed	GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.	C17orf78 TIPARP	7.92e-04	32	45	2	23535730
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR7G1 OR4B1 OR4X2 OR2AP1	9.75e-04	340	45	4	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR7G1 OR4B1 OR4X2 OR2AP1	9.75e-04	340	45	4	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR7G1 OR4B1 OR4X2 OR2AP1	1.01e-03	343	45	4	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR7G1 OR4B1 OR4X2 OR2AP1	1.04e-03	346	45	4	14611657
Pubmed	Ion channel expression in the developing enteric nervous system.	KCNA1 KCNA4	1.06e-03	37	45	2	25798587
Pubmed	International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels.	KCNA1 KCNA4	1.24e-03	40	45	2	16382104
GeneFamily	ATP binding cassette subfamily A	ABCA1 ABCA12	2.56e-04	14	31	2	805
GeneFamily	Potassium voltage-gated channels	KCNA1 KCNA4	2.13e-03	40	31	2	274
GeneFamily	Solute carriers	SLC28A1 SLC11A2 SLC24A2 SLC25A31	4.43e-03	395	31	4	752
GeneFamily	Olfactory receptors, family 4	OR4B1 OR4X2	2.05e-02	129	31	2	151
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DOCK5 CERS2 FAM124A SLC24A2 FAIM2	1.66e-06	198	45	5	bdabdb11217ea16e5863aa6bfb0f04d48b17f81e
ToppCell	facs-Lung-Endomucin-24m-Endothelial-Capillary_Type_1_Cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SLC28A1 ATP2B3 CRHBP USP29	1.39e-05	145	45	4	96712c68ab759d7ade0d912581a1a7c25dc6def8
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	SLC28A1 ATP2B3 CRHBP USP29	2.15e-05	162	45	4	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	LPS-IL1RA+antiTNF-Myeloid-Neutrophils\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK5 P2RY13 SLC11A2 PDCD1LG2	3.39e-05	182	45	4	243c783675df495ea4112dbf710712c44ea6b4f1
ToppCell	LPS-IL1RA+antiTNF-Myeloid-Neutrophils-Neutrophils\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK5 P2RY13 SLC11A2 PDCD1LG2	3.39e-05	182	45	4	18790a394dc32b3cef99cdbf826392c520e38b4a
ToppCell	facs-Brain_Non-Myeloid-Cortex_-18m-Macroglial-oligodendrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CERS2 KCNA1 SLC24A2 FAIM2	4.18e-05	192	45	4	3916de42b9a626b5679ca98057d6e69f146b2810
ToppCell	facs-Brain_Non-Myeloid-Striatum\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNA1 KCNA4 SLC24A2 ADCY5	4.26e-05	193	45	4	d8ccfb780a75bdf9141f41fb29a076958601ebb4
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-D\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DOCK5 FAM124A SLC24A2 FAIM2	4.26e-05	193	45	4	947200ef6c3a2e35ad7e6b4af29d92384bdf73f5
ToppCell	facs-Brain_Non-Myeloid-Striatum-3m\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KCNA1 KCNA4 SLC24A2 ADCY5	4.35e-05	194	45	4	ba529c051f248d29f4222f4bc9801ba233859093
ToppCell	Tracheal-NucSeq-Epithelial-Epi_airway_neuro-secretory-Neuroendocrine\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	TSPEAR KCNA1 KCNA4 TAF1L	4.53e-05	196	45	4	95544097577f20ed7f4144bd940471cde0617554
ToppCell	10x5'v1-week_12-13-Myeloid_macrophage-stroma-stromal_macrophage\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	SLC28A1 ABCA1 ADAM9 PDCD1LG2	4.62e-05	197	45	4	075044c17f1c52008cd3c292c15cbf485b50411e
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte-B\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DOCK5 FAM124A SLC24A2 ADCY5	4.62e-05	197	45	4	82b8e22317cad6d3786bd70d91107007c0ccd7cd
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK5 KCNA1 SLC24A2 FAIM2	4.62e-05	197	45	4	7b12f9d4ad1e84df58e86591a491c84d4f36eac5
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Macroglial-oligodendrocyte\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK5 KCNA1 SLC24A2 FAIM2	4.71e-05	198	45	4	97ae237f955fd5fbd01d06aafe89ef9e6f777a9a
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DOCK5 FAM124A SLC24A2 FAIM2	4.89e-05	200	45	4	0bfd41c12887479ceb62c3db0a3c3ba5007eb62b
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal-Oligodendrocyte\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DOCK5 FAM124A SLC24A2 FAIM2	4.89e-05	200	45	4	159377d904394d91e09913131e9a93e08189955a
ToppCell	10x_3'_v2v3-Non-neoplastic-Glial-Neuronal\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DOCK5 FAM124A SLC24A2 FAIM2	4.89e-05	200	45	4	d30316836494f33ca46d4e415fd2ed179e9cb5ee
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DOCK5 CERS2 SLC24A2 FAIM2	4.89e-05	200	45	4	acdef0b9096c774040948fc75621ff2b08ea2ee8
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte-Oligodendrocyte\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DOCK5 CERS2 SLC24A2 FAIM2	4.89e-05	200	45	4	091a18d6efed81cab99955c3047f172170f70476
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Glial-Neuronal-Oligodendrocyte\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	DOCK5 CERS2 SLC24A2 FAIM2	4.89e-05	200	45	4	3b8513defe25262ab4b492345b2628570eaefd17
ToppCell	Hippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Lhx1_(Cajal-retzius)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	TSPEAR SLC25A31 PDCD1LG2	8.72e-05	85	45	3	f9e874ae2b3eadf58fbbe7367c5f498a357166ca
ToppCell	Hippocampus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a6-Excitatory_Neuron.Slc17a6.Lhx1_(Cajal-retzius)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	TSPEAR SLC25A31 PDCD1LG2	8.72e-05	85	45	3	2c94ff338633c39edb4a3a69a04be33db764c586
Disease	Parkinsonism (implicated_via_orthology)	SLC11A2 GFRA1	8.60e-04	29	44	2	DOID:0080855 (implicated_via_orthology)
Disease	fear of minor pain measurement	DOCK5 TBC1D22A	9.83e-04	31	44	2	EFO_0008340
Disease	suicide behaviour measurement	TSPEAR OR7G1	1.89e-03	43	44	2	EFO_0006882

Protein segments in the cluster

Peptide	Gene	Start	Entry
FVVFVVSFVIPCPDR	FAM234A	61	Q9H0X4
DPEAFLSICFVTLVF	BTNL10	6	A8MVZ5
AFFPFIVLVTVENEL	ABCA12	1186	Q86UK0
GFFAQIVLPAVFVCI	ABCA1	1346	O95477
SGVAIIVFVIFEVPC	C17orf78	196	Q8N4C9
VFLFICFVQITIVPH	ADCY5	771	O95622
CNNIFIVFAIVFIIT	CERS2	261	Q96G23
VFDGIFSNPIFCTIV	ATP2B3	996	Q16720
VPFTEEQLFSIFDIV	RBM45	256	Q8IUH3
FIPFCIIAFIFIATV	PDCD1LG2	226	Q9BQ51
SCVDNFFEPQIFVIF	TIPARP	621	Q7Z3E1
IFTDPFFIVETLCII	KCNA1	216	Q09470
VTLAVVALFTFCDPV	FAIM2	116	Q9BWQ8
CIFPIFSNLDVDIQF	FAM124A	206	Q86V42
LVIVFTLCFPIVFFI	PCNX1	1116	Q96RV3
VDVVVTGVVDECIFF	FBXO46	366	Q6PJ61
PNQEVQRVCFVIFLF	OR4X2	11	Q8NGF9
KTFFVESICVDPEVI	PFKFB4	151	Q16877
CIALFVSFIINVFVV	SLC11A2	301	P49281
TDVPELQVAVFTFLF	OR2AP1	16	Q8NGE2
LDFTFVCPTEIIAFS	PRDX1	46	Q06830
IVNVRDICNEFPVVF	PASD1	131	Q8IV76
KVFVVVAVFFVCFAP	P2RY13	256	Q9BPV8
SFSIIPCFVFVESVL	PLPPR2	11	Q96GM1
NVEIPLFFCEVVQVI	OR7G1	171	Q8NGA0
PFLVSFFIAQVVTTC	SLC25A31	221	Q9H0C2
FDPVELSVLFCKFIQ	DOCK5	831	Q9H7D0
CAAFFISEPEEFITI	CRHBP	81	P24387
IFRVVPFISDVFQQV	GFRA1	131	P56159
VFFFLIVPLIVCAIF	ADAM9	701	Q13443
FQAKFDTFVVPCVVA	CFAP74	1191	Q9C0B2
FQDPAVQSVCFVVFL	OR4B1	16	Q8NGF8
VYVTVSFPFNVEICR	UBOX5	51	O94941
VIQVEPFCCVVFAEA	SLFN14	311	P0C7P3
VFCVAIFIFLVNGVV	TMEM132A	856	Q24JP5
FIALAIVCDEFFVPS	SLC24A2	146	Q9UI40
VDIFVVGQQCPLFEV	TAF1L	796	Q8IZX4
IVGVAFFNVLEIPCF	PLA2G3	231	Q9NZ20
FFNVLEIPCFVLEEQ	PLA2G3	236	Q9NZ20
NCIEVFVSLTNFEPV	NCAPD3	241	P42695
IFTIGVQDFVPFVQC	TRAPPC11	576	Q7Z392
ATKVFVCPVVANFEF	USP29	416	Q9HBJ7
GINDLVTPFFVVFIC	TBC1D22A	321	Q8WUA7
VTPFFVVFICEYIEA	TBC1D22A	326	Q8WUA7
CIIPFAVVVFIAGIV	TMEM100	56	Q9NV29
VFAFQVLPIIVFFSC	SLC28A1	261	O00337
IFSQCDLFPEEFSIV	TSPEAR	76	Q8WU66
IFNDPFFIVETVCIV	KCNA4	366	P22459