Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	glutamate receptor activity	GRIK1 GRIK5 GRM1	9.66e-06	27	31	3	GO:0008066
GeneOntologyMolecularFunction	kainate selective glutamate receptor activity	GRIK1 GRIK5	3.49e-05	6	31	2	GO:0015277
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	FLT1 GRIK1 GRIK5 GRM1 CELSR2 GPR150 FZD2 IL17RE GPR179	1.51e-04	1353	31	9	GO:0004888
GeneOntologyMolecularFunction	postsynaptic neurotransmitter receptor activity	GRIK1 GRIK5 GRM1	2.12e-04	75	31	3	GO:0098960
GeneOntologyMolecularFunction	glutamate-gated receptor activity	GRIK1 GRIK5	3.13e-04	17	31	2	GO:0004970
GeneOntologyMolecularFunction	ligand-gated sodium channel activity	GRIK1 GRIK5	3.51e-04	18	31	2	GO:0015280
GeneOntologyMolecularFunction	neurotransmitter receptor activity	GRIK1 GRIK5 GRM1	4.95e-04	100	31	3	GO:0030594
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	GRIK1 GRIK5	6.30e-04	24	31	2	GO:0099507
GeneOntologyMolecularFunction	sodium channel activity	GRIK1 GRIK5	2.95e-03	52	31	2	GO:0005272
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	GRIK1 GRIK5	3.53e-03	57	31	2	GO:1904315
GeneOntologyMolecularFunction	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	GRIK1 GRIK5	3.90e-03	60	31	2	GO:0099529
GeneOntologyMolecularFunction	transmitter-gated channel activity	GRIK1 GRIK5	4.57e-03	65	31	2	GO:0022835
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity	GRIK1 GRIK5	4.57e-03	65	31	2	GO:0022824
GeneOntologyCellularComponent	kainate selective glutamate receptor complex	GRIK1 GRIK5	3.39e-05	6	32	2	GO:0032983
GeneOntologyCellularComponent	cell pole	ASTN2 GPR179	4.24e-04	20	32	2	GO:0060187
GeneOntologyCellularComponent	sodium channel complex	GRIK1 GRIK5	8.98e-04	29	32	2	GO:0034706
GeneOntologyCellularComponent	postsynaptic density membrane	GRIK1 GRIK5 GRM1	1.76e-03	157	32	3	GO:0098839
GeneOntologyCellularComponent	ionotropic glutamate receptor complex	GRIK1 GRIK5	2.16e-03	45	32	2	GO:0008328
GeneOntologyCellularComponent	neurotransmitter receptor complex	GRIK1 GRIK5	2.66e-03	50	32	2	GO:0098878
MousePheno	abnormal glomerular filtration barrier function	LAMB2 GRM1	2.15e-05	4	27	2	MP:0011856
MousePheno	short excitatory postsynaptic current decay time	GRIK5 GRM1	5.36e-05	6	27	2	MP:0011274
Domain	EGF_LAM_2	ATRN LAMB2 CELSR2	1.80e-05	30	32	3	PS50027
Domain	EGF_LAM_1	ATRN LAMB2 CELSR2	1.80e-05	30	32	3	PS01248
Domain	Laminin_EGF	ATRN LAMB2 CELSR2	2.88e-05	35	32	3	PF00053
Domain	EGF_Lam	ATRN LAMB2 CELSR2	2.88e-05	35	32	3	SM00180
Domain	ANF_receptor	GRIK1 GRIK5 GRM1	3.41e-05	37	32	3	PF01094
Domain	ANF_lig-bd_rcpt	GRIK1 GRIK5 GRM1	3.41e-05	37	32	3	IPR001828
Domain	Laminin_EGF	ATRN LAMB2 CELSR2	3.70e-05	38	32	3	IPR002049
Domain	Peripla_BP_I	GRIK1 GRIK5 GRM1	4.00e-05	39	32	3	IPR028082
Domain	EGF	ATRN LAMB2 ZAN CELSR2 GPR179	4.61e-05	235	32	5	SM00181
Domain	EGF_1	ATRN LAMB2 ASTN2 ZAN CELSR2	6.80e-05	255	32	5	PS00022
Domain	EGF_2	ATRN LAMB2 ASTN2 ZAN CELSR2	8.15e-05	265	32	5	PS01186
Domain	Growth_fac_rcpt_	ATRN LAMB2 CELSR2 GPR179	1.40e-04	156	32	4	IPR009030
Domain	Iontro_rcpt	GRIK1 GRIK5	4.28e-04	18	32	2	IPR001320
Domain	Lig_chan	GRIK1 GRIK5	4.28e-04	18	32	2	PF00060
Domain	Lig_chan-Glu_bd	GRIK1 GRIK5	4.28e-04	18	32	2	PF10613
Domain	PBPe	GRIK1 GRIK5	4.28e-04	18	32	2	SM00079
Domain	Iono_rcpt_met	GRIK1 GRIK5	4.28e-04	18	32	2	IPR001508
Domain	Glu/Gly-bd	GRIK1 GRIK5	4.28e-04	18	32	2	IPR019594
Domain	Lig_chan-Glu_bd	GRIK1 GRIK5	4.28e-04	18	32	2	SM00918
Domain	ConA-like_dom	PAPPA2 ZAN CELSR2 NBEAL2	5.11e-04	219	32	4	IPR013320
Domain	GPCR_3	GRM1 GPR179	5.85e-04	21	32	2	IPR000337
Domain	G_PROTEIN_RECEP_F3_4	GRM1 GPR179	6.43e-04	22	32	2	PS50259
Domain	7tm_3	GRM1 GPR179	6.43e-04	22	32	2	PF00003
Domain	GPCR_3_C	GRM1 GPR179	6.43e-04	22	32	2	IPR017978
Domain	G_PROTEIN_RECEP_F3_2	GRM1 GPR179	6.43e-04	22	32	2	PS00980
Domain	G_PROTEIN_RECEP_F3_3	GRM1 GPR179	6.43e-04	22	32	2	PS00981
Domain	G_PROTEIN_RECEP_F3_1	GRM1 GPR179	6.43e-04	22	32	2	PS00979
Domain	EGF_3	ATRN ASTN2 ZAN CELSR2	6.66e-04	235	32	4	PS50026
Domain	EGF-like_dom	ATRN LAMB2 ZAN CELSR2	8.27e-04	249	32	4	IPR000742
Domain	EGF-like_CS	ATRN LAMB2 ZAN CELSR2	9.85e-04	261	32	4	IPR013032
Domain	EGF	ATRN ZAN CELSR2	1.29e-03	126	32	3	PF00008
Domain	-	ATRN LZTR1	3.05e-03	48	32	2	2.120.10.80
Domain	CUB	ATRN CSMD3	3.18e-03	49	32	2	PF00431
Domain	CUB	ATRN CSMD3	3.31e-03	50	32	2	SM00042
Domain	Sushi	PAPPA2 CSMD3	3.57e-03	52	32	2	PF00084
Domain	-	ATRN CSMD3	3.57e-03	52	32	2	2.60.120.290
Domain	CUB	ATRN CSMD3	3.71e-03	53	32	2	PS01180
Domain	CCP	PAPPA2 CSMD3	3.85e-03	54	32	2	SM00032
Domain	Kelch-typ_b-propeller	ATRN LZTR1	3.99e-03	55	32	2	IPR015915
Domain	SUSHI	PAPPA2 CSMD3	4.13e-03	56	32	2	PS50923
Domain	Sushi_SCR_CCP_dom	PAPPA2 CSMD3	4.28e-03	57	32	2	IPR000436
Domain	CUB_dom	ATRN CSMD3	4.28e-03	57	32	2	IPR000859
Domain	Gal_Oxase/kelch_b-propeller	ATRN LZTR1	4.58e-03	59	32	2	IPR011043
Domain	GPCR_2-like	CELSR2 FZD2	4.73e-03	60	32	2	IPR017981
Domain	GPCR_2_secretin-like	CELSR2 FZD2	4.73e-03	60	32	2	IPR000832
Domain	G_PROTEIN_RECEP_F2_4	CELSR2 FZD2	4.89e-03	61	32	2	PS50261
Domain	FN3_dom	PAPPA2 ASTN2 POMGNT2	5.39e-03	209	32	3	IPR003961
Domain	Kelch_1	ATRN LZTR1	6.39e-03	70	32	2	PF01344
Domain	Kelch_1	ATRN LZTR1	6.39e-03	70	32	2	IPR006652
Pathway	KEGG_MEDICUS_REFERENCE_MANNOSE_TYPE_O_GLYCAN_BIOSYNTHESIS_POMT_TO_POMK	POMT2 POMGNT2	2.77e-05	5	24	2	M47610
Pathway	REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS	GRIK1 GRIK5	1.24e-04	10	24	2	M10272
Pathway	REACTOME_IONOTROPIC_ACTIVITY_OF_KAINATE_RECEPTORS	GRIK1 GRIK5	1.81e-04	12	24	2	MM15142
Pathway	WP_GPCRS_OTHER	GRM1 CELSR2 FZD2	5.58e-04	96	24	3	MM15939
Pubmed	Presynaptic localization of GluK5 in rod photoreceptors suggests a novel function of high affinity glutamate receptors in the mammalian retina.	GRIK1 GRIK5	9.28e-07	2	34	2	28235022
Pubmed	CaMKII-dependent phosphorylation of GluK5 mediates plasticity of kainate receptors.	GRIK1 GRIK5	9.28e-07	2	34	2	23288040
Pubmed	Glutamate can act as a signaling molecule in mouse preimplantation embryos†.	GRIK1 GRIK5 GRM1	1.70e-06	24	34	3	35746896
Pubmed	Distinct roles for the kainate receptor subunits GluR5 and GluR6 in kainate-induced hippocampal gamma oscillations.	GRIK1 GRIK5	2.78e-06	3	34	2	15509753
Pubmed	Effect of RNA editing and subunit co-assembly single-channel properties of recombinant kainate receptors.	GRIK1 GRIK5	2.78e-06	3	34	2	8730589
Pubmed	Homeostatic control of synaptic transmission by distinct glutamate receptors.	GRIK1 GRIK5	2.78e-06	3	34	2	23719165
Pubmed	Differential roles for group 1 mGluR subtypes in induction and expression of chemically induced hippocampal long-term depression.	GRIK1 GRM1	2.78e-06	3	34	2	16421200
Pubmed	mGlu1 Receptors Monopolize the Synaptic Control of Cerebellar Purkinje Cells by Epigenetically Down-Regulating mGlu5 Receptors.	GRIK1 GRM1	5.56e-06	4	34	2	30190524
Pubmed	Kainate receptors and rhythmic activity in neuronal networks: hippocampal gamma oscillations as a tool.	GRIK1 GRIK5	5.56e-06	4	34	2	15513934
Pubmed	Distinct subunits in heteromeric kainate receptors mediate ionotropic and metabotropic function at hippocampal mossy fiber synapses.	GRIK1 GRIK5	5.56e-06	4	34	2	16354929
Pubmed	Kainate receptors act as conditional amplifiers of spike transmission at hippocampal mossy fiber synapses.	GRIK1 GRIK5	5.56e-06	4	34	2	19369569
Pubmed	Localization of glutamate receptors to distal dendrites depends on subunit composition and the kinesin motor protein KIF17.	GRIK1 GRIK5	5.56e-06	4	34	2	17174564
Pubmed	Developmental expression patterns of kainate receptors in the mouse spinal cord.	GRIK1 GRIK5	9.26e-06	5	34	2	23076118
Pubmed	Kainate receptors: pharmacology, function and therapeutic potential.	GRIK1 GRIK5	9.26e-06	5	34	2	18793656
Pubmed	Complete Disruption of the Kainate Receptor Gene Family Results in Corticostriatal Dysfunction in Mice.	GRIK1 GRIK5	9.26e-06	5	34	2	28228252
Pubmed	Kainate receptor subunits underlying presynaptic regulation of transmitter release in the dorsal horn.	GRIK1 GRIK5	9.26e-06	5	34	2	12223554
Pubmed	Molecular determinants of kainate receptor trafficking.	GRIK1 GRIK5	9.26e-06	5	34	2	18358623
Pubmed	Development of laminar distributions of kainate receptors in the somatosensory cortex of mice.	GRIK1 GRIK5	9.26e-06	5	34	2	9593973
Pubmed	Preferential assembly of heteromeric kainate and AMPA receptor amino terminal domains.	GRIK1 GRIK5	9.26e-06	5	34	2	29058671
Pubmed	Homer: a protein that selectively binds metabotropic glutamate receptors.	GRIK1 GRM1	1.39e-05	6	34	2	9069287
Pubmed	Agonist-independent activation of metabotropic glutamate receptors by the intracellular protein Homer.	GRIK1 GRM1	1.39e-05	6	34	2	11418862
Pubmed	N-glycan content modulates kainate receptor functional properties.	GRIK1 GRIK5	1.39e-05	6	34	2	28714086
Pubmed	Seven placental transcripts characterize HELLP-syndrome.	PAPPA2 FLT1	1.94e-05	7	34	2	18374411
Pubmed	Short-term plasticity of kainate receptor-mediated EPSCs induced by NMDA receptors at hippocampal mossy fiber synapses.	GRIK1 GRIK5	1.94e-05	7	34	2	17428973
Pubmed	Glutamate binding and conformational flexibility of ligand-binding domains are critical early determinants of efficient kainate receptor biogenesis.	GRIK1 GRIK5	1.94e-05	7	34	2	19342380
Pubmed	Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins.	GRIK1 GRM1	1.94e-05	7	34	2	9808458
Pubmed	Primary structure and expression of the gamma 2 subunit of the glutamate receptor channel selective for kainate.	GRIK1 GRIK5	1.94e-05	7	34	2	1310861
Pubmed	Splicing and editing of ionotropic glutamate receptors: a comprehensive analysis based on human RNA-Seq data.	GRIK1 GRIK5	3.33e-05	9	34	2	34100982
Pubmed	Expression of glutamate receptor subunit genes during development of the mouse retina.	GRIK1 GRIK5	3.33e-05	9	34	2	9051806
Pubmed	Caspase 9 is constitutively activated in mouse oocytes and plays a key role in oocyte elimination during meiotic prophase progression.	XIAP MSH5	4.15e-05	10	34	2	23384561
Pubmed	AGO61-dependent GlcNAc modification primes the formation of functional glycans on α-dystroglycan.	POMT2 POMGNT2	6.08e-05	12	34	2	24256719
Pubmed	Tlx1/3 and Ptf1a control the expression of distinct sets of transmitter and peptide receptor genes in the developing dorsal spinal cord.	GRIK1 GRIK5 GRM1	6.91e-05	81	34	3	22723691
Pubmed	Role of chromatin remodeling gene Cecr2 in neurulation and inner ear development.	CELSR2 FZD2	7.19e-05	13	34	2	21246654
Pubmed	Glutamatergic gene variants impact the clinical profile of efficacy and side effects of haloperidol.	GRIK1 GRM1	7.19e-05	13	34	2	20859245
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	CCDC142 LAMB2 LZTR1 POMGNT2 CELSR2 IL17RE NBEAL2	8.14e-05	1105	34	7	35748872
Pubmed	Congenital Muscular Dystrophy Overview – RETIRED CHAPTER, FOR HISTORICAL REFERENCE ONLY	POMT2 POMGNT2	1.25e-04	17	34	2	20301468
Pubmed	Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells.	FLT1 FZD2	1.57e-04	19	34	2	21623369
Pubmed	Putative complement control protein CSMD3 dysfunction impairs synaptogenesis and induces neurodevelopmental disorders.	GRM1 CSMD3	2.12e-04	22	34	2	35245678
Pubmed	Patterned expression of ion channel genes in mouse dorsal raphe nucleus determined with the Allen Mouse Brain Atlas.	GRIK1 GRIK5	2.53e-04	24	34	2	22534482
Pubmed	Functional analysis and identification of cis-regulatory elements of human chromosome 21 gene promoters.	GRIK1 LINC00315	5.10e-04	34	34	2	20494980
Pubmed	TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.	POMT2 LAMB2 POMGNT2	5.53e-04	164	34	3	32409323
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	SP4 MTA1 GRM1 TSPYL2	7.97e-04	430	34	4	35044719
Pubmed	Malformation of Tear Ducts Underlies the Epiphora and Precocious Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for Tear Duct Genesis.	CELSR2 FZD2	9.75e-04	47	34	2	33141892
Interaction	CRISP2 interactions	ATRN LAMB2 POMGNT2	3.13e-05	40	31	3	int:CRISP2
Cytoband	17q21.1	FZD2 GPR179	1.00e-04	20	34	2	17q21.1
Cytoband	3p22.1	ZNF619 POMGNT2	4.08e-04	40	34	2	3p22.1
Cytoband	Ensembl 112 genes in cytogenetic band chr3p22	ZNF619 POMGNT2	8.24e-03	184	34	2	chr3p22
GeneFamily	Glutamate ionotropic receptor kainate type subunits	GRIK1 GRIK5	2.14e-05	5	27	2	1199
GeneFamily	Hyalectan proteoglycans\|V-set domain containing\|Sushi domain containing\|C-type lectin domain containing	PAPPA2 CSMD3	3.26e-03	57	27	2	1179
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXHD1 NEB ZAN GRM1 CSMD3	2.74e-07	184	34	5	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXHD1 NEB ZAN GRM1 CSMD3	2.74e-07	184	34	5	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LOXHD1 NEB ZAN GRM1 CSMD3	2.74e-07	184	34	5	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	367C-Lymphocytic-ILC\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	ASTN2 FLT1 MSH5 LZTR1	6.10e-06	157	34	4	f511871e1a004c6e9af08ee325ab1bfc41807487
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-4M-Stem_cells-neuroepithelial-like_cells\|Organoid-4M / Sample Type, Dataset, Time_group, and Cell type.	LZTR1 NEB IL17RE PRSS36	7.78e-06	167	34	4	e488d9c7cf4355959e3833de3bd496c13fc11b1b
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ASTN2 FLT1 GRIK1 GRM1	1.32e-05	191	34	4	9c0ee270209b02043393416ecc9a81ddedfbb8b6
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	ASTN2 FLT1 GRIK1 GRM1	1.38e-05	193	34	4	8b77625bf3c87d39767fb391d1beaca4ab02342b
Drug	3HPG	GRIK1 GRIK5 GRM1	2.04e-06	17	34	3	CID000001217
Drug	acromelic acid A	GRIK1 GRIK5 GRM1	2.44e-06	18	34	3	CID000108086
Drug	LY382884	GRIK1 GRIK5 GRM1	2.90e-06	19	34	3	CID000656723
Drug	4-carboxy-3-hydroxyphenylglycine	GRIK1 GRIK5 GRM1	3.41e-06	20	34	3	CID000001297
Drug	YM90K	GRIK1 GRIK5 GRM1	5.28e-06	23	34	3	CID005486547
Drug	Cyclosporin A [59865-13-3]; Up 200; 3.4uM; MCF7; HT_HG-U133A	POMT2 LAMB2 LZTR1 FZD2 TSPYL2	5.88e-06	175	34	5	3267_UP
Drug	CGP 39653	GRIK1 GRIK5 GRM1	6.03e-06	24	34	3	CID006437837
Drug	gavestinel	GRIK1 GRIK5 GRM1	6.84e-06	25	34	3	CID006450546
Drug	L-689,560	GRIK1 GRIK5 GRM1	8.68e-06	27	34	3	CID000121918
Drug	Norfloxacin [70458-96-7]; Down 200; 12.6uM; MCF7; HT_HG-U133A	POMT2 ASTN2 MTA1 GRM1 NBEAL2	9.47e-06	193	34	5	5985_DN
Drug	aptiganel	GRIK1 GRIK5 GRM1	9.72e-06	28	34	3	CID000060839
Drug	C-PP	GRIK1 GRIK5 GRM1	9.72e-06	28	34	3	CID000001228
Drug	Carbimazole [22232-54-8]; Down 200; 21.4uM; MCF7; HT_HG-U133A	POMT2 PAPPA2 ATRN MTA1 UST	1.05e-05	197	34	5	3299_DN
Drug	Nomegestrol acetate [58652-20-3]; Down 200; 10.8uM; PC3; HT_HG-U133A	POMT2 ASTN2 GRIK5 LZTR1 NBEAL2	1.07e-05	198	34	5	6362_DN
Drug	AC1NUW3V	GRIK1 GRIK5 GRM1	1.08e-05	29	34	3	CID005462126
Drug	ketobemidone	GRIK1 GRIK5 GRM1	1.08e-05	29	34	3	CID000010101
Drug	cis-2,3-piperidine dicarboxylic acid	GRIK1 GRIK5 GRM1	1.20e-05	30	34	3	CID000001226
Drug	LY293558	GRIK1 GRIK5 GRM1	1.20e-05	30	34	3	CID000127894
Drug	AC1L32TU	GRIK1 GRIK5 GRM1	1.20e-05	30	34	3	CID000107831
Drug	GYKI 53655	GRIK1 GRIK5 GRM1	1.20e-05	30	34	3	CID000126757
Drug	aminothiazole 6	GRIK1 GRIK5	1.30e-05	4	34	2	CID005329388
Drug	acromelic acid B	GRIK1 GRIK5	1.30e-05	4	34	2	CID000158974
Drug	Brn 1074551	GRIK1 GRIK5	1.30e-05	4	34	2	CID000120220
Drug	4-methyleneglutamic acid	GRIK1 GRIK5	1.30e-05	4	34	2	CID000096407
Drug	diCl-HQC	GRIK1 GRIK5	1.30e-05	4	34	2	CID003018579
Drug	LY235959	GRIK1 GRIK5 GRM1	1.33e-05	31	34	3	CID000131938
Drug	NPC 12626	GRIK1 GRIK5 GRM1	1.33e-05	31	34	3	CID000108099
Drug	4-methylglutamic acid	GRIK1 GRIK5 GRM1	1.33e-05	31	34	3	CID000005365
Drug	eliprodil	GRIK1 GRIK5 GRM1	1.33e-05	31	34	3	CID000060703
Drug	alpha-methyl-4-carboxyphenylglycine	GRIK1 GRIK5 GRM1	1.47e-05	32	34	3	CID000001222
Drug	TG-3	GRIK1 GRIK5 GRM1	1.61e-05	33	34	3	CID000205489
Drug	1-aminoindan-1,5-dicarboxylic acid	GRIK1 GRIK5 GRM1	1.61e-05	33	34	3	CID000002071
Drug	D-CPPene	GRIK1 GRIK5 GRM1	1.76e-05	34	34	3	CID006435801
Drug	CPPG	GRIK1 GRIK5 GRM1	1.76e-05	34	34	3	CID000002878
Drug	kainite	GRIK1 GRIK5 GRM1	1.93e-05	35	34	3	CID000164810
Drug	gacyclidine	GRIK1 GRIK5 GRM1	2.10e-05	36	34	3	CID000176265
Drug	R,S)-AMPA	GRIK1 GRIK5 GRM1	2.10e-05	36	34	3	CID000001221
Drug	C6H12NO5P	GRIK1 GRIK5 GRM1	2.10e-05	36	34	3	CID000104962
Drug	glutamic acid diethyl ester	GRIK1 GRIK5 GRM1	2.10e-05	36	34	3	CID000073960
Drug	bromowillardiine	GRIK1 GRIK5	2.16e-05	5	34	2	CID000167842
Drug	ipenoxazone	GRIK1 GRIK5	2.16e-05	5	34	2	CID000065882
Drug	pBB-PzDA	GRIK1 GRIK5	2.16e-05	5	34	2	CID000124528
Drug	3-hydroxy-2-quinoxalinecarboxylic acid	GRIK1 GRIK5	2.16e-05	5	34	2	CID000071001
Drug	pyrimidine-2,4-dione	GRIK1 GRIK5	2.16e-05	5	34	2	CID000150747
Drug	CGS 19755	GRIK1 GRIK5 GRM1	2.48e-05	38	34	3	CID000068736
Drug	4CPG	GRIK1 GRIK5 GRM1	2.48e-05	38	34	3	CID000005115
Drug	L-BMAA	GRIK1 GRIK5 GRM1	2.48e-05	38	34	3	CID000028558
Drug	DETC-MeSO	GRIK1 GRIK5 GRM1	2.68e-05	39	34	3	CID003035711
Drug	HA-966	GRIK1 GRIK5 GRM1	2.68e-05	39	34	3	CID000001232
Drug	3-acetylisoquinoline	GRIK1 GRIK5	3.23e-05	6	34	2	CID000124656
Drug	LY341495	GRIK1 GRIK5 GRM1	3.60e-05	43	34	3	CID006324636
Drug	Joro spider toxin	GRIK1 GRIK5 GRM1	3.60e-05	43	34	3	CID000119582
Drug	7-chlorokynurenic acid	GRIK1 GRIK5 GRM1	4.14e-05	45	34	3	CID000001884
Drug	fluorocyclobutane	GRIK1 GRIK5	4.52e-05	7	34	2	CID011051569
Drug	KB-R7943	GRIK1 GRIK5 GRM1	4.72e-05	47	34	3	CID004534086
Drug	avermectin	GRIK1 GRIK5 GRM1	5.03e-05	48	34	3	CID006450460
Drug	5,7-dichlorokynurenic acid	GRIK1 GRIK5 GRM1	5.35e-05	49	34	3	CID000001779
Drug	L-CCG-I	GRIK1 GRIK5 GRM1	5.68e-05	50	34	3	CID000001271
Drug	homoibotenic acid	GRIK1 GRM1	6.03e-05	8	34	2	CID000194385
Drug	AC1L1B65	GRIK1 GRIK5	6.03e-05	8	34	2	CID000001300
Drug	perzinfotel	GRIK1 GRIK5	6.03e-05	8	34	2	CID006918236
Drug	1v79	GRIK1 GRIK5	6.03e-05	8	34	2	CID000449014
Drug	LY354740	GRIK1 GRIK5 GRM1	6.03e-05	51	34	3	CID000114827
Drug	AC1L1EKQ	GRIK1 GRIK5 GRM1	6.40e-05	52	34	3	CID000002834
Drug	13-methoxyibogamine	GRIK1 GRIK5 GRM1	7.16e-05	54	34	3	CID000065749
Drug	Ly294486	GRIK1 GRIK5	7.74e-05	9	34	2	CID005311255
Drug	1m5b	GRIK1 GRIK5	7.74e-05	9	34	2	CID000447081
Drug	benzo(F)quinoxaline	GRIK1 GRIK5	7.74e-05	9	34	2	CID000098494
Drug	LY339434	GRIK1 GRIK5	7.74e-05	9	34	2	CID006324635
Drug	propyl pyrazole triol	GRIK1 GRIK5	7.74e-05	9	34	2	CID006095481
Drug	NS3763	GRIK1 GRIK5	7.74e-05	9	34	2	CID004359312
Drug	GYKI 52466	GRIK1 GRIK5 GRM1	8.88e-05	58	34	3	CID000003538
Drug	SR 95531	GRIK1 GRIK5 GRM1	9.34e-05	59	34	3	CID000005275
Drug	MPEP	GRIK1 GRIK5 GRM1	9.34e-05	59	34	3	CID003025961
Drug	AC1L1CXL	GRIK1 GRIK5	9.67e-05	10	34	2	CID000002106
Drug	3,5-dihydroxyphenylglycine	GRIK1 GRIK5 GRM1	9.82e-05	60	34	3	CID000108001
Drug	AP-7	GRIK1 GRIK5 GRM1	1.14e-04	63	34	3	CID000003122
Drug	J-ST	GRIK1 GRM1	1.18e-04	11	34	2	CID005288655
Drug	sym 2206	GRIK1 GRIK5	1.18e-04	11	34	2	CID005039877
Drug	AMN082	GRIK1 GRM1	1.42e-04	12	34	2	CID001894360
Drug	Atpa	GRIK1 GRIK5	1.42e-04	12	34	2	CID000002252
Drug	L-Glutamic Acid	GRIK1 GRIK5 GRM1	1.43e-04	68	34	3	DB00142
Drug	strychnine HCl	PAPPA2 GRIK1 GRIK5 GRM1	1.49e-04	181	34	4	CID000005304
Drug	felbamate	GRIK1 GRIK5 GRM1	1.56e-04	70	34	3	CID000003331
Drug	Flunisolide [3385-03-3]; Up 200; 9.2uM; HL60; HT_HG-U133A	PAPPA2 SP4 FLT1 MTA1	1.58e-04	184	34	4	2168_UP
Drug	ifenprodil	GRIK1 GRIK5 GRM1	1.62e-04	71	34	3	CID000003689
Drug	T2755	GRIK1 GRIK5 GRM1	1.62e-04	71	34	3	CID000005514
Drug	Mspg	GRIK1 GRM1	1.67e-04	13	34	2	CID003964410
Drug	alpha-aminoadipate	GRIK1 GRIK5 GRM1	1.76e-04	73	34	3	CID000000469
Drug	Naftopidil dihydrochloride [57149-08-3]; Up 200; 8.6uM; HL60; HT_HG-U133A	LAMB2 GRIK5 NEB CELSR2	1.79e-04	190	34	4	2911_UP
Drug	Tranylcypromine hydrochloride [1986-47-6]; Up 200; 23.6uM; HL60; HG-U133A	POMT2 GRIK5 LZTR1 FZD2	1.83e-04	191	34	4	1417_UP
Drug	AC1L1E5T	GRIK1 GRIK5 GRM1	1.83e-04	74	34	3	CID000002653
Drug	Methantheline bromide [53-46-3]; Down 200; 9.6uM; MCF7; HT_HG-U133A	ASTN2 LZTR1 NEB NBEAL2	1.86e-04	192	34	4	6254_DN
Drug	AC1L1DME	GRIK1 GRIK5 GRM1	1.91e-04	75	34	3	CID000002414
Drug	NU1025; Up 200; 100uM; MCF7; HG-U133A	ATRN SP4 GRIK5 GRM1	1.94e-04	194	34	4	608_UP
Drug	Rifampicin [13292-46-1]; Down 200; 4.8uM; MCF7; HT_HG-U133A	PAPPA2 LZTR1 MTA1 UST	1.94e-04	194	34	4	4126_DN
Drug	Glimepiride [93479-97-1]; Up 200; 8.2uM; PC3; HT_HG-U133A	POMT2 PAPPA2 FLT1 GRIK1	1.94e-04	194	34	4	6628_UP
Drug	Isradipine [75695-93-1]; Down 200; 10.8uM; PC3; HT_HG-U133A	POMT2 LZTR1 CELSR2 TSPYL2	1.94e-04	194	34	4	6347_DN
Drug	Sulindac [38194-50-2]; Up 200; 11.2uM; HL60; HT_HG-U133A	SP4 GRIK5 NEB TSPYL2	1.98e-04	195	34	4	1857_UP
Drug	Prazosin hydrochloride [19237-84-4]; Down 200; 9.6uM; MCF7; HT_HG-U133A	PAPPA2 ASTN2 GRIK5 NEB	1.98e-04	195	34	4	5416_DN
Disease	MUSCULAR DYSTROPHY, LIMB-GIRDLE, TYPE 2K	POMT2 POMGNT2	1.09e-04	14	33	2	C1836373
Disease	alpha-Dystroglycanopathies	POMT2 POMGNT2	1.09e-04	14	33	2	C2936406
Disease	Muscle eye brain disease	POMT2 POMGNT2	1.09e-04	14	33	2	C0457133
Disease	Fukuyama Type Congenital Muscular Dystrophy	POMT2 POMGNT2	1.09e-04	14	33	2	C0410174
Disease	Muscular Dystrophy-Dystroglycanopathy (Congenital with Brain and Eye Anomalies) Type A, 1	POMT2 POMGNT2	1.09e-04	14	33	2	C4284790
Disease	Walker-Warburg congenital muscular dystrophy	POMT2 POMGNT2	1.26e-04	15	33	2	C0265221
Disease	bipolar I disorder	ASTN2 SP4 PRSS36	5.25e-04	141	33	3	EFO_0009963
Disease	temporal lobe epilepsy (biomarker_via_orthology)	GRIK5 GRM1	5.53e-04	31	33	2	DOID:3328 (biomarker_via_orthology)
Disease	Muscular Dystrophies, Limb-Girdle	POMT2 POMGNT2	5.89e-04	32	33	2	C0686353
Disease	myocardial infarction	PAPPA2 LAMB2 FLT1 CELSR2	6.07e-04	350	33	4	EFO_0000612
Disease	aspirin use measurement	FLT1 CELSR2	8.76e-04	39	33	2	EFO_0007013

Protein segments in the cluster

Peptide	Gene	Start	Entry
HGVSRNWNHPLPRCE	CSMD3	2266	Q7Z407
LQCHRHKPWRLGPRF	GRIK1	346	P39086
HQRPRWHLPFFSCLG	CCDC142	731	Q17RM4
TAVRHCDEHRGWLPP	CELSR2	2006	Q9HCU4
PDPVHRHLCVRSDWG	ASTN2	541	O75129
VHRWRRLPPCDEFVG	LZTR1	51	Q8N653
ERGHHSPAPARARLW	GPR179	1016	Q6PRD1
ACDRWSVLPRPDLHH	ATRN	596	O75882
IGFRHLPHWNTRCPL	IL17RE	26	Q8NFR9
PGWHCSHVDIRRLLP	LOXHD1	1181	Q8IVV2
VCAEPWRHQRARDPA	FAM157A	316	C9JC47
QWPERLRCEHFPRHG	FZD2	131	Q14332
LPWRPAEDGHSHACR	LAMB2	331	P55268
VPRHLCCRNPEWLFR	POMGNT2	431	Q8NAT1
WPVCLPRASHRFVHG	PRSS36	156	Q5K4E3
GRRQWHPDPVLVHCI	PAPPA2	1716	Q9BXP8
RWHVPSDGLCRPCHV	LINC00315	111	P59091
EWYNPHPCLRARPHI	GRIK5	571	Q16478
FWQHRFQCRLPGHLL	GRM1	371	Q13255
RHWLARGPTCPHIFV	MSH5	691	O43196
AHLRWHTGERPFICN	SP4	666	Q02446
TRFHRLDEPPHICWD	POMT2	71	Q9UKY4
AWHCVAIVHVPGRRP	NBEAL2	676	Q6ZNJ1
RCHGIFAPLPRWHLQ	GPR150	216	Q8NGU9
GHRACHYLRPDAPWR	SOWAHD	221	A6NJG2
CREILRPWHAARHPY	MTA1	486	Q13330
HPRCREPGEWALERA	UST	256	Q9Y2C2
PIRWHRGQEPQARRH	TSPYL2	341	Q9H2G4
EPCDRAWSEHRRHFP	XIAP	211	P98170
CWHRDPKERPRFAEL	FLT1	1136	P17948
WGRGPERHVHRLECN	ZNF619	56	Q8N2I2
HIRDGIRHGLWICPF	TMEM267	156	Q0VDI3
GRLRQHPRLCLQWHP	ZAN	2631	Q9Y493
IWRSIPDRPEHFHHR	NEB	5311	P20929