Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ryanodine-sensitive calcium-release channel activity	RYR1 RYR2 RYR3	2.15e-08	4	36	3	GO:0005219
GeneOntologyMolecularFunction	intracellularly gated calcium channel activity	MCOLN3 RYR1 RYR2 RYR3	2.67e-08	18	36	4	GO:0015278
GeneOntologyMolecularFunction	calcium-induced calcium release activity	RYR1 RYR2 RYR3	1.07e-07	6	36	3	GO:0048763
GeneOntologyMolecularFunction	ligand-gated calcium channel activity	MCOLN3 RYR1 RYR2 RYR3	2.70e-07	31	36	4	GO:0099604
GeneOntologyMolecularFunction	intracellularly ligand-gated monoatomic ion channel activity	MCOLN3 RYR1 RYR2 RYR3	3.51e-07	33	36	4	GO:0005217
GeneOntologyMolecularFunction	calcium channel activity	MCOLN3 RYR1 RYR2 RYR3	8.34e-05	129	36	4	GO:0005262
GeneOntologyMolecularFunction	ligand-gated monoatomic cation channel activity	MCOLN3 RYR1 RYR2 RYR3	1.15e-04	140	36	4	GO:0099094
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	MCOLN3 RYR1 RYR2 RYR3	1.53e-04	151	36	4	GO:0015085
GeneOntologyMolecularFunction	protease binding	FN1 TIMP3 LPA RYR1	3.07e-04	181	36	4	GO:0002020
GeneOntologyMolecularFunction	calcium ion binding	VWCE TBC1D8B LRP1B RYR1 RYR2 RYR3 USP32	3.28e-04	749	36	7	GO:0005509
GeneOntologyMolecularFunction	monoatomic cation channel activity	MCOLN3 RYR1 RYR2 CALHM2 RYR3	3.54e-04	343	36	5	GO:0005261
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	MCOLN3 RYR1 RYR2 RYR3	3.91e-04	193	36	4	GO:0015276
GeneOntologyMolecularFunction	ligand-gated channel activity	MCOLN3 RYR1 RYR2 RYR3	4.23e-04	197	36	4	GO:0022834
GeneOntologyMolecularFunction	monoatomic ion channel activity	MCOLN3 RYR1 RYR2 CALHM2 RYR3	1.31e-03	459	36	5	GO:0005216
GeneOntologyMolecularFunction	RNA nuclease activity	XRN2 PIWIL1 ZC3H12D	1.87e-03	136	36	3	GO:0004540
GeneOntologyMolecularFunction	channel activity	MCOLN3 RYR1 RYR2 CALHM2 RYR3	2.37e-03	525	36	5	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	MCOLN3 RYR1 RYR2 CALHM2 RYR3	2.39e-03	526	36	5	GO:0022803
GeneOntologyMolecularFunction	gated channel activity	MCOLN3 RYR1 RYR2 RYR3	2.97e-03	334	36	4	GO:0022836
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	MCOLN3 RYR1 RYR2 CALHM2 RYR3	6.43e-03	664	36	5	GO:0008324
GeneOntologyMolecularFunction	catalytic activity, acting on RNA	XRN2 QARS1 PIWIL1 ZC3H12D	6.51e-03	417	36	4	GO:0140098
GeneOntologyMolecularFunction	calmodulin binding	RYR1 RYR2 RYR3	8.14e-03	230	36	3	GO:0005516
GeneOntologyMolecularFunction	nuclease activity	XRN2 PIWIL1 ZC3H12D	8.24e-03	231	36	3	GO:0004518
GeneOntologyMolecularFunction	RNA endonuclease activity	PIWIL1 ZC3H12D	8.92e-03	79	36	2	GO:0004521
GeneOntologyBiologicalProcess	cellular response to caffeine	RYR1 RYR2 RYR3	9.42e-07	11	38	3	GO:0071313
GeneOntologyBiologicalProcess	cellular response to purine-containing compound	RYR1 RYR2 RYR3	2.07e-06	14	38	3	GO:0071415
GeneOntologyBiologicalProcess	response to caffeine	RYR1 RYR2 RYR3	7.50e-06	21	38	3	GO:0031000
GeneOntologyBiologicalProcess	calcium-mediated signaling	TMIGD3 MCOLN3 RYR1 RYR2 BTK RYR3	8.49e-06	266	38	6	GO:0019722
GeneOntologyBiologicalProcess	release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	RYR1 RYR2 RYR3	4.29e-05	37	38	3	GO:0014808
GeneOntologyBiologicalProcess	release of sequestered calcium ion into cytosol by endoplasmic reticulum	RYR1 RYR2 RYR3	5.04e-05	39	38	3	GO:1903514
GeneOntologyBiologicalProcess	cellular response to alkaloid	RYR1 RYR2 RYR3	5.44e-05	40	38	3	GO:0071312
GeneOntologyBiologicalProcess	sarcoplasmic reticulum calcium ion transport	RYR1 RYR2 RYR3	7.25e-05	44	38	3	GO:0070296
GeneOntologyBiologicalProcess	histamine secretion involved in inflammatory response	TMIGD3 BTK	3.90e-04	16	38	2	GO:0002441
GeneOntologyBiologicalProcess	histamine production involved in inflammatory response	TMIGD3 BTK	3.90e-04	16	38	2	GO:0002349
GeneOntologyBiologicalProcess	histamine secretion by mast cell	TMIGD3 BTK	3.90e-04	16	38	2	GO:0002553
GeneOntologyBiologicalProcess	glial cell migration	PTPRB FN1 APCDD1	4.30e-04	80	38	3	GO:0008347
GeneOntologyCellularComponent	calcium channel complex	CATSPERE RYR1 RYR2 RYR3	1.03e-05	73	39	4	GO:0034704
GeneOntologyCellularComponent	sarcoplasmic reticulum membrane	RYR1 RYR2 RYR3	8.07e-05	45	39	3	GO:0033017
GeneOntologyCellularComponent	smooth endoplasmic reticulum	RYR1 RYR2 RYR3	8.62e-05	46	39	3	GO:0005790
GeneOntologyCellularComponent	junctional membrane complex	RYR1 RYR3	1.21e-04	9	39	2	GO:0030314
GeneOntologyCellularComponent	junctional sarcoplasmic reticulum membrane	RYR1 RYR2	1.51e-04	10	39	2	GO:0014701
GeneOntologyCellularComponent	sarcoplasmic reticulum	RYR1 RYR2 RYR3	5.90e-04	88	39	3	GO:0016529
GeneOntologyCellularComponent	cation channel complex	CATSPERE RYR1 RYR2 RYR3	9.40e-04	235	39	4	GO:0034703
GeneOntologyCellularComponent	sarcoplasm	RYR1 RYR2 RYR3	1.25e-03	114	39	3	GO:0016528
GeneOntologyCellularComponent	Z disc	RYR1 RYR2 RYR3	2.79e-03	151	39	3	GO:0030018
GeneOntologyCellularComponent	voltage-gated calcium channel complex	CATSPERE RYR1	3.33e-03	46	39	2	GO:0005891
GeneOntologyCellularComponent	I band	RYR1 RYR2 RYR3	3.64e-03	166	39	3	GO:0031674
Domain	RyR	RYR1 RYR2 RYR3	6.03e-09	3	35	3	PF02026
Domain	Ryanodine_rcpt	RYR1 RYR2 RYR3	6.03e-09	3	35	3	IPR003032
Domain	RR_TM4-6	RYR1 RYR2 RYR3	6.03e-09	3	35	3	PF06459
Domain	Ryanrecept_TM4-6	RYR1 RYR2 RYR3	6.03e-09	3	35	3	IPR009460
Domain	Ryan_recept	RYR1 RYR2 RYR3	6.03e-09	3	35	3	IPR013333
Domain	RIH_assoc	RYR1 RYR2 RYR3	1.20e-07	6	35	3	PF08454
Domain	RIH_assoc-dom	RYR1 RYR2 RYR3	1.20e-07	6	35	3	IPR013662
Domain	RYDR_ITPR	RYR1 RYR2 RYR3	1.20e-07	6	35	3	PF01365
Domain	RIH_dom	RYR1 RYR2 RYR3	1.20e-07	6	35	3	IPR000699
Domain	Ins145_P3_rcpt	RYR1 RYR2 RYR3	1.20e-07	6	35	3	IPR014821
Domain	Ryanodine_recept-rel	RYR1 RYR2 RYR3	1.20e-07	6	35	3	IPR015925
Domain	Ins145_P3_rec	RYR1 RYR2 RYR3	1.20e-07	6	35	3	PF08709
Domain	-	RYR1 RYR2 RYR3	1.20e-07	6	35	3	1.25.10.30
Domain	MIR	RYR1 RYR2 RYR3	7.17e-07	10	35	3	PS50919
Domain	MIR	RYR1 RYR2 RYR3	7.17e-07	10	35	3	PF02815
Domain	MIR	RYR1 RYR2 RYR3	7.17e-07	10	35	3	SM00472
Domain	MIR_motif	RYR1 RYR2 RYR3	7.17e-07	10	35	3	IPR016093
Domain	Ion_trans_dom	MCOLN3 RYR1 RYR2 RYR3	5.96e-05	114	35	4	IPR005821
Domain	Ion_trans	MCOLN3 RYR1 RYR2 RYR3	5.96e-05	114	35	4	PF00520
Domain	EF_hand_dom	TBC1D8B RYR1 RYR2 RYR3 USP32	6.78e-05	232	35	5	IPR002048
Domain	-	TBC1D8B RYR1 RYR2 RYR3 USP32	1.18e-04	261	35	5	1.10.238.10
Domain	EF-hand-dom_pair	TBC1D8B RYR1 RYR2 RYR3 USP32	1.84e-04	287	35	5	IPR011992
Domain	KRTAP	KRTAP20-2 KRTAP22-1	3.53e-04	15	35	2	PF11759
Domain	KRTAP_type6/8/16/19/20/21	KRTAP20-2 KRTAP22-1	3.53e-04	15	35	2	IPR021743
Domain	SPRY	RYR1 RYR2 RYR3	5.74e-04	87	35	3	SM00449
Domain	SPRY	RYR1 RYR2 RYR3	7.19e-04	94	35	3	PF00622
Domain	SPRY_dom	RYR1 RYR2 RYR3	7.19e-04	94	35	3	IPR003877
Domain	B30.2/SPRY	RYR1 RYR2 RYR3	7.42e-04	95	35	3	IPR001870
Domain	B302_SPRY	RYR1 RYR2 RYR3	7.42e-04	95	35	3	PS50188
Domain	EF_HAND_2	TBC1D8B RYR2 RYR3 USP32	8.83e-04	231	35	4	PS50222
Domain	Kringle-like	FN1 LPA	1.63e-03	32	35	2	IPR013806
Domain	EF-hand_8	RYR1 RYR2	1.84e-03	34	35	2	PF13833
Domain	TBC	TBC1D10B TBC1D8B	3.80e-03	49	35	2	SM00164
Domain	RabGAP-TBC	TBC1D10B TBC1D8B	4.43e-03	53	35	2	PF00566
Domain	TBC_RABGAP	TBC1D10B TBC1D8B	4.76e-03	55	35	2	PS50086
Domain	Rab-GTPase-TBC_dom	TBC1D10B TBC1D8B	4.76e-03	55	35	2	IPR000195
Domain	ConA-like_dom	RYR1 RYR2 RYR3	7.90e-03	219	35	3	IPR013320
Pathway	KEGG_MEDICUS_REFERENCE_CA2_CAM_VGCC_RYR_SIGNALING_PATHWAY	RYR1 RYR2 RYR3	5.40e-07	11	22	3	M47958
Pathway	WP_CELLTYPE_DEPENDENT_SELECTIVITY_OF_CCK2R_SIGNALING	RYR1 RYR2 RYR3	9.34e-07	13	22	3	M39589
Pathway	KEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_MGLUR5_CA2_APOPTOTIC_PATHWAY	RYR1 RYR2 RYR3	3.15e-06	19	22	3	M47760
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	MCOLN3 RYR1 RYR2 RYR3	1.52e-05	99	22	4	MM14910
Pathway	REACTOME_STIMULI_SENSING_CHANNELS	MCOLN3 RYR1 RYR2 RYR3	1.99e-05	106	22	4	M27200
Pathway	REACTOME_ION_HOMEOSTASIS	RYR1 RYR2 RYR3	7.77e-05	54	22	3	MM15202
Pathway	REACTOME_ION_HOMEOSTASIS	RYR1 RYR2 RYR3	7.77e-05	54	22	3	M27460
Pathway	REACTOME_ION_CHANNEL_TRANSPORT	MCOLN3 RYR1 RYR2 RYR3	1.44e-04	176	22	4	MM15718
Pathway	REACTOME_ION_CHANNEL_TRANSPORT	MCOLN3 RYR1 RYR2 RYR3	1.67e-04	183	22	4	M997
Pathway	REACTOME_CARDIAC_CONDUCTION	RYR1 RYR2 RYR3	5.27e-04	103	22	3	MM15196
Pathway	REACTOME_RESPONSE_TO_ELEVATED_PLATELET_CYTOSOLIC_CA2	FN1 TIMP3 LPA	1.04e-03	130	22	3	MM15455
Pathway	REACTOME_CARDIAC_CONDUCTION	RYR1 RYR2 RYR3	1.04e-03	130	22	3	M27454
Pathway	WP_CALCIUM_REGULATION_IN_CARDIAC_CELLS	RYR1 RYR2 RYR3	1.48e-03	147	22	3	MM15854
Pathway	WP_CALCIUM_REGULATION_IN_CARDIAC_CELLS	RYR1 RYR2 RYR3	1.60e-03	151	22	3	M39329
Pathway	WP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS	RYR1 RYR2 RYR3	1.69e-03	154	22	3	MM15974
Pathway	WP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS	RYR1 RYR2 RYR3	1.75e-03	156	22	3	M39475
Pathway	REACTOME_MUSCLE_CONTRACTION	RYR1 RYR2 RYR3	2.06e-03	165	22	3	MM15026
Pathway	WP_15Q25_COPY_NUMBER_VARIATION	RYR1 RYR2	2.31e-03	46	22	2	M48105
Pathway	KEGG_CALCIUM_SIGNALING_PATHWAY	RYR1 RYR2 RYR3	2.55e-03	178	22	3	M2890
Pubmed	Type 1 and type 3 ryanodine receptors are selectively involved in muscarinic antinociception in mice: an antisense study.	RYR1 RYR2 RYR3	1.30e-09	3	39	3	18403125
Pubmed	Heterogeneous gene expression and functional activity of ryanodine receptors in resistance and conduit pulmonary as well as mesenteric artery smooth muscle cells.	RYR1 RYR2 RYR3	1.30e-09	3	39	3	18434746
Pubmed	SPRY domains in ryanodine receptors (Ca(2+)-release channels).	RYR1 RYR2 RYR3	1.30e-09	3	39	3	9204703
Pubmed	The ryanodine receptor/calcium channel genes are widely and differentially expressed in murine brain and peripheral tissues.	RYR1 RYR2 RYR3	1.30e-09	3	39	3	7876312
Pubmed	Ryanodine receptors are expressed in epidermal keratinocytes and associated with keratinocyte differentiation and epidermal permeability barrier homeostasis.	RYR1 RYR2 RYR3	1.30e-09	3	39	3	21881589
Pubmed	Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).	RYR1 RYR2 RYR3	1.30e-09	3	39	3	12213830
Pubmed	Expression of the ryanodine receptor type 3 calcium release channel during development and differentiation of mammalian skeletal muscle cells.	RYR1 RYR2 RYR3	1.30e-09	3	39	3	9242641
Pubmed	Bidirectional coupling between ryanodine receptors and Ca2+ release-activated Ca2+ (CRAC) channel machinery sustains store-operated Ca2+ entry in human T lymphocytes.	RYR1 RYR2 RYR3	1.30e-09	3	39	3	22948152
Pubmed	Developmental changes in expression of the three ryanodine receptor mRNAs in the mouse brain.	RYR1 RYR2 RYR3	1.30e-09	3	39	3	10788707
Pubmed	Calcineurin upregulates local Ca(2+) signaling through ryanodine receptor-1 in airway smooth muscle cells.	RYR1 RYR2 RYR3	1.30e-09	3	39	3	25239916
Pubmed	Ca(2+)-induced Ca2+ release in myocytes from dyspedic mice lacking the type-1 ryanodine receptor.	RYR1 RYR2 RYR3	1.30e-09	3	39	3	7621815
Pubmed	A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice.	RYR1 RYR2 RYR3	1.30e-09	3	39	3	18643873
Pubmed	Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).	RYR1 RYR2 RYR3	1.30e-09	3	39	3	11159936
Pubmed	Molecular identification of the ryanodine receptor pore-forming segment.	RYR1 RYR2 RYR3	1.30e-09	3	39	3	10473538
Pubmed	Chromosomal localization of murine ryanodine receptor genes RYR1, RYR2, and RYR3 by in situ hybridization.	RYR1 RYR2 RYR3	1.30e-09	3	39	3	7959768
Pubmed	The organization of proteins in the human red blood cell membrane. A review.	RYR1 RYR2 RYR3	1.30e-09	3	39	3	4600883
Pubmed	Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs.	RYR1 RYR2 RYR3	1.30e-09	3	39	3	7635066
Pubmed	A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons.	RYR1 RYR2 RYR3	5.21e-09	4	39	3	18206662
Pubmed	Ryanodine receptor calcium release channels: lessons from structure-function studies.	RYR1 RYR2 RYR3	5.21e-09	4	39	3	23413940
Pubmed	Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.	RYR1 RYR2 RYR3	5.21e-09	4	39	3	9384575
Pubmed	Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum.	RYR1 RYR2 RYR3	5.21e-09	4	39	3	9607712
Pubmed	Conserved and divergent functions of Nfix in skeletal muscle development during vertebrate evolution.	RYR1 RYR2 RYR3	5.21e-09	4	39	3	23482488
Pubmed	Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons.	RYR1 RYR2 RYR3	1.30e-08	5	39	3	23918386
Pubmed	Protein kinase C-epsilon regulates local calcium signaling in airway smooth muscle cells.	RYR1 RYR2 RYR3	1.30e-08	5	39	3	19011160
Pubmed	Membrane depolarization causes a direct activation of G protein-coupled receptors leading to local Ca2+ release in smooth muscle.	RYR1 RYR2 RYR3	2.60e-08	6	39	3	19549818
Pubmed	Rectification of muscle and nerve deficits in paralyzed ryanodine receptor type 1 mutant embryos.	RYR1 RYR2 RYR3	2.60e-08	6	39	3	26025922
Pubmed	Roles of I(f) and intracellular Ca2+ release in spontaneous activity of ventricular cardiomyocytes during murine embryonic development.	RYR1 RYR2 RYR3	2.60e-08	6	39	3	23463619
Pubmed	FKBP12.6 and cADPR regulation of Ca2+ release in smooth muscle cells.	RYR1 RYR2 RYR3	2.60e-08	6	39	3	14592808
Pubmed	A calcium-induced calcium release mechanism supports luteinizing hormone-induced testosterone secretion in mouse Leydig cells.	RYR1 RYR2 RYR3	2.60e-08	6	39	3	20519450
Pubmed	Essential Roles of Intracellular Calcium Release Channels in Muscle, Brain, Metabolism, and Aging.	RYR1 RYR2 RYR3	2.60e-08	6	39	3	25966694
Pubmed	HIV-1 Tat activates neuronal ryanodine receptors with rapid induction of the unfolded protein response and mitochondrial hyperpolarization.	RYR1 RYR2 RYR3	2.60e-08	6	39	3	19009018
Pubmed	IP3Rs are sufficient for dendritic cell Ca2+ signaling in the absence of RyR1.	RYR1 RYR2 RYR3	2.60e-08	6	39	3	16844763
Pubmed	Developmental expression of the calcium release channels during early neurogenesis of the mouse cerebral cortex.	RYR1 RYR2 RYR3	4.55e-08	7	39	3	11860456
Pubmed	Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax.	RYR1 RYR2 RYR3	4.55e-08	7	39	3	20962236
Pubmed	Roles of IP3R and RyR Ca2+ channels in endoplasmic reticulum stress and beta-cell death.	RYR1 RYR2 RYR3	7.27e-08	8	39	3	19033399
Pubmed	Sequential docking, molecular differentiation, and positioning of T-Tubule/SR junctions in developing mouse skeletal muscle.	RYR1 RYR2 RYR3	7.27e-08	8	39	3	11784029
Pubmed	New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes.	RYR1 RYR2 RYR3	2.85e-07	12	39	3	19095005
Pubmed	Altered ryanodine receptor expression in mild cognitive impairment and Alzheimer's disease.	RYR2 RYR3	1.23e-06	2	39	2	21531043
Pubmed	Modulation of calcium signalling by dominant negative splice variant of ryanodine receptor subtype 3 in native smooth muscle cells.	RYR2 RYR3	1.23e-06	2	39	2	16678258
Pubmed	Principal mutation hotspot for central core disease and related myopathies in the C-terminal transmembrane region of the RYR1 gene.	RYR1 RYR3	1.23e-06	2	39	2	12565913
Pubmed	Contractile impairment and structural alterations of skeletal muscles from knockout mice lacking type 1 and type 3 ryanodine receptors.	RYR1 RYR3	1.23e-06	2	39	2	9489997
Pubmed	Skeletal and cardiac ryanodine receptors exhibit different responses to Ca2+ overload and luminal ca2+.	RYR1 RYR2	1.23e-06	2	39	2	17259277
Pubmed	Functional and morphological features of skeletal muscle from mutant mice lacking both type 1 and type 3 ryanodine receptors.	RYR1 RYR3	1.23e-06	2	39	2	9192302
Pubmed	The block of ryanodine receptors selectively inhibits fetal myoblast differentiation.	RYR1 RYR3	1.23e-06	2	39	2	12640042
Pubmed	Ryanodine receptor oligomeric interaction: identification of a putative binding region.	RYR1 RYR2	1.23e-06	2	39	2	14722100
Pubmed	Structural and functional interactions within ryanodine receptor.	RYR1 RYR2	1.23e-06	2	39	2	26009179
Pubmed	Isolation and partial cloning of ryanodine-sensitive Ca2+ release channel protein isoforms from human myometrial smooth muscle.	RYR1 RYR3	1.23e-06	2	39	2	7556644
Pubmed	Elements in the C terminus of apolipoprotein [a] responsible for the binding to the tenth type III module of human fibronectin.	FN1 LPA	1.23e-06	2	39	2	16150826
Pubmed	Structure and Function of the Human Ryanodine Receptors and Their Association with Myopathies-Present State, Challenges, and Perspectives.	RYR1 RYR2	1.23e-06	2	39	2	32899693
Pubmed	Possible involvement of ryanodine receptor-mediated intracellular calcium release in the effect of corticotropin-releasing factor on adrenocorticotropin secretion.	RYR1 RYR3	1.23e-06	2	39	2	14592949
Pubmed	Tissue-specific alternative splicing of mouse brain type ryanodine receptor/calcium release channel mRNA.	RYR2 RYR3	1.23e-06	2	39	2	8898078
Pubmed	Ryanodine receptors in muscarinic receptor-mediated bronchoconstriction.	RYR1 RYR3	1.23e-06	2	39	2	15894801
Pubmed	Recent advances in understanding the ryanodine receptor calcium release channels and their role in calcium signalling.	RYR1 RYR2	1.23e-06	2	39	2	30542613
Pubmed	The mouse sino-atrial node expresses both the type 2 and type 3 Ca(2+) release channels/ryanodine receptors.	RYR2 RYR3	1.23e-06	2	39	2	14550562
Pubmed	Ryanodine receptors are expressed and functionally active in mouse spermatogenic cells and their inhibition interferes with spermatogonial differentiation.	RYR1 RYR2	1.23e-06	2	39	2	15280431
Pubmed	Expression of the ryanodine receptor isoforms in immune cells.	RYR1 RYR2	1.23e-06	2	39	2	11673493
Pubmed	B-lymphocytes from malignant hyperthermia-susceptible patients have an increased sensitivity to skeletal muscle ryanodine receptor activators.	RYR1 RYR2	1.23e-06	2	39	2	11673462
Pubmed	Morphological abnormalities of adrenal gland and hypertrophy of liver in mutant mice lacking ryanodine receptors.	RYR1 RYR3	1.23e-06	2	39	2	9799464
Pubmed	Lipoprotein(a) binds to fibronectin and has serine proteinase activity capable of cleaving it.	FN1 LPA	1.23e-06	2	39	2	2531657
Pubmed	Effect of calmodulin on Ca2+-induced Ca2+ release of skeletal muscle from mutant mice expressing either ryanodine receptor type 1 or type 3.	RYR1 RYR3	1.23e-06	2	39	2	9817784
Pubmed	Crystal structures of wild type and disease mutant forms of the ryanodine receptor SPRY2 domain.	RYR1 RYR2	1.23e-06	2	39	2	25370123
Pubmed	Decreased expression of ryanodine receptors alters calcium-induced calcium release mechanism in mdx duodenal myocytes.	RYR2 RYR3	1.23e-06	2	39	2	14985349
Pubmed	Ryanodine receptors in human pancreatic beta cells: localization and effects on insulin secretion.	RYR1 RYR2	1.23e-06	2	39	2	15033925
Pubmed	Thermodynamics of calmodulin binding to cardiac and skeletal muscle ryanodine receptor ion channels.	RYR1 RYR2	1.23e-06	2	39	2	18618700
Pubmed	Expression and functional activity of ryanodine receptors (RyRs) during skeletal muscle development.	RYR1 RYR3	1.23e-06	2	39	2	17118445
Pubmed	RyR3 amplifies RyR1-mediated Ca(2+)-induced Ca(2+) release in neonatal mammalian skeletal muscle.	RYR1 RYR3	1.23e-06	2	39	2	11500519
Pubmed	Characterization and mapping of the 12 kDa FK506-binding protein (FKBP12)-binding site on different isoforms of the ryanodine receptor and of the inositol 1,4,5-trisphosphate receptor.	RYR1 RYR3	3.67e-06	3	39	2	11171121
Pubmed	Novel interaction of apolipoprotein(a) with beta-2 glycoprotein I mediated by the kringle IV domain.	FN1 LPA	3.67e-06	3	39	2	9269765
Pubmed	Differential alterations in expressions of ryanodine receptor subtypes in cerebellar cortical neurons of an ataxic mutant, rolling mouse Nagoya.	RYR1 RYR3	3.67e-06	3	39	2	18313230
Pubmed	Control of Neuronal Ryanodine Receptor-Mediated Calcium Signaling by Calsenilin.	RYR2 RYR3	3.67e-06	3	39	2	29730765
Pubmed	Dendritic differentiation of cerebellar Purkinje cells is promoted by ryanodine receptors expressed by Purkinje and granule cells.	RYR1 RYR2	3.67e-06	3	39	2	24123915
Pubmed	Dopamine D1 receptor signaling system regulates ryanodine receptor expression in ethanol physical dependence.	RYR1 RYR2	3.67e-06	3	39	2	23278119
Pubmed	Direct association of the reticulon protein RTN1A with the ryanodine receptor 2 in neurons.	RYR1 RYR2	3.67e-06	3	39	2	23454728
Pubmed	RYR2 proteins contribute to the formation of Ca(2+) sparks in smooth muscle.	RYR2 RYR3	3.67e-06	3	39	2	15024040
Pubmed	Intracellular calcium release channel expression during embryogenesis.	RYR1 RYR2	3.67e-06	3	39	2	9986730
Pubmed	Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels.	RYR1 RYR3	7.34e-06	4	39	2	22100703
Pubmed	Increase of ryanodine receptors by dopamine D1 receptors is negatively regulated by γ-aminobutyric acid type B receptors in primary cultures of mouse cerebral cortical neurons.	RYR1 RYR2	7.34e-06	4	39	2	22504960
Pubmed	Calmodulin modulates the termination threshold for cardiac ryanodine receptor-mediated Ca2+ release.	RYR1 RYR2	7.34e-06	4	39	2	23992453
Pubmed	Tissue inhibitor of metalloproteinases 3 regulates extracellular matrix--cell signaling during bronchiole branching morphogenesis.	FN1 TIMP3	7.34e-06	4	39	2	16890932
Pubmed	Plasmin-mediated processing of protein tyrosine phosphatase receptor type Z in the mouse brain.	PTPRB LPA	7.34e-06	4	39	2	18647637
Pubmed	S100A1 Protein Does Not Compete with Calmodulin for Ryanodine Receptor Binding but Structurally Alters the Ryanodine Receptor·Calmodulin Complex.	RYR1 RYR2	7.34e-06	4	39	2	27226555
Pubmed	Hypoxia differently modulates gene expression of inositol 1,4,5-trisphosphate receptors in mouse kidney and HEK 293 cell line.	RYR1 RYR2	7.34e-06	4	39	2	19120137
Pubmed	FKBP binding characteristics of cardiac microsomes from diverse vertebrates.	RYR1 RYR2	7.34e-06	4	39	2	11237759
Pubmed	Maternal Transient Receptor Potential Vanilloid 6 (Trpv6) Is Involved In Offspring Bone Development.	RYR1 RYR2 RYR3	1.07e-05	38	39	3	30786075
Pubmed	Localization of the Mas proto-oncogene to a densely marked region of mouse chromosome 17 associated with genomic imprinting.	MAS1 LPA	1.22e-05	5	39	2	1612602
Pubmed	A null mutation for tissue inhibitor of metalloproteinases-3 (Timp-3) impairs murine bronchiole branching morphogenesis.	FN1 TIMP3	1.22e-05	5	39	2	14499643
Pubmed	Sorcin is an early marker of neurodegeneration, Ca2+ dysregulation and endoplasmic reticulum stress associated to neurodegenerative diseases.	RYR2 RYR3	1.22e-05	5	39	2	33060591
Pubmed	Role of leaky neuronal ryanodine receptors in stress-induced cognitive dysfunction.	RYR1 RYR2	1.22e-05	5	39	2	22939628
Pubmed	Intracellular calcium-release channels: regulators of cell life and death.	RYR1 RYR2	1.22e-05	5	39	2	9124414
Pubmed	Type 3 and type 1 ryanodine receptors are localized in triads of the same mammalian skeletal muscle fibers.	RYR1 RYR3	1.83e-05	6	39	2	10444070
Pubmed	Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.	MORC4 TBC1D8B	2.56e-05	7	39	2	23143602
Pubmed	Bidirectional action of the Igf2r imprint control element on upstream and downstream imprinted genes.	MAS1 LPA	3.42e-05	8	39	2	11562346
Pubmed	High-resolution genetic analysis of a deletion on mouse chromosome 17 extending over the fused, tufted, and homeobox Nkx2-5 loci.	MAS1 LPA	3.42e-05	8	39	2	7894168
Pubmed	Long-range DNase I hypersensitivity mapping reveals the imprinted Igf2r and Air promoters share cis-regulatory elements.	MAS1 LPA	3.42e-05	8	39	2	16204191
Pubmed	Neuromuscular synaptic patterning requires the function of skeletal muscle dihydropyridine receptors.	RYR1 RYR3	3.42e-05	8	39	2	21441923
Pubmed	ORAI1, STIM1/2, and RYR1 shape subsecond Ca2+ microdomains upon T cell activation.	RYR1 RYR3	3.42e-05	8	39	2	30563862
Pubmed	Tissue-specific regulation of Igf2r/Airn imprinting during gastrulation.	MAS1 LPA	4.39e-05	9	39	2	25918552
Pubmed	Increased muscle stress-sensitivity induced by selenoprotein N inactivation in mouse: a mammalian model for SEPN1-related myopathy.	RYR1 RYR3	4.39e-05	9	39	2	21858002
Pubmed	Mouse ZAR1-like (XM_359149) colocalizes with mRNA processing components and its dominant-negative mutant caused two-cell-stage embryonic arrest.	ZAR1 PIWIL1	4.39e-05	9	39	2	20014101
Pubmed	Bioinformatics and cellular signaling.	FN1 RYR1 RYR2 BTK	5.17e-05	182	39	4	15102471
Cytoband	Xq22.3	MORC4 TBC1D8B	3.65e-04	33	39	2	Xq22.3
Cytoband	Ensembl 112 genes in cytogenetic band chrXq22	MORC4 TBC1D8B BTK	4.28e-04	172	39	3	chrXq22
Cytoband	21q22.1	KRTAP20-2 KRTAP22-1	5.11e-04	39	39	2	21q22.1
Cytoband	Ensembl 112 genes in cytogenetic band chr2q35	FN1 MARCHF4	5.42e-03	129	39	2	chr2q35
Cytoband	Ensembl 112 genes in cytogenetic band chr6q25	MAS1 ZC3H12D	8.62e-03	164	39	2	chr6q25
Cytoband	7q34	TRBV16 TRBV13	8.92e-03	167	39	2	7q34
Cytoband	Ensembl 112 genes in cytogenetic band chr7q34	TRBV16 TRBV13	1.09e-02	185	39	2	chr7q34
GeneFamily	Ryanodine receptors\|Protein phosphatase 1 regulatory subunits	RYR1 RYR2 RYR3	3.33e-09	3	28	3	287
GeneFamily	EF-hand domain containing	TBC1D8B RYR2 RYR3 USP32	3.41e-04	219	28	4	863
ToppCell	Severe-CD4+_T_activated\|Severe / Disease group and Cell class	TRBV16 APCDD1 TTC21A RYR2 FRMD3	4.60e-07	177	39	5	a08f170f1143fcdd7d0842a54d9b807a4548f8b7
ToppCell	Severe-CD4+_T_activated\|World / Disease group and Cell class	TRBV16 APCDD1 TTC21A RYR2 FRMD3	4.73e-07	178	39	5	ef6111238703579a34bd6948bd9d4ca6b7e16063
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell_prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB FN1 APCDD1 TIMP3	1.24e-05	163	39	4	1feb4ef7b8abcfca9a72c8d13c40548de79e7db2
ToppCell	Bronchial_Biopsy-Immune-Mast_cells\|Immune / Tissue, Lineage and Cell class of Lung Cells from 10X	PTPRB TBC1D8B MAS1 RYR3	1.39e-05	168	39	4	45ccc0cb42d21f4853190e8e9ed9a54aefefe738
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB FN1 TIMP3 CALHM2	1.60e-05	174	39	4	3d4c05ea5719ca65e85d1f15198453034791087c
ToppCell	390C-Fibroblasts-Fibroblast-B_(Myofibroblast)\|390C / Donor, Lineage, Cell class and subclass (all cells)	FN1 APCDD1 TIMP3 RYR2	1.67e-05	176	39	4	852d3da0907fe87c0ef23d75a63ce07619cf0c54
ToppCell	390C-Fibroblasts-Fibroblast-B_(Myofibroblast)-\|390C / Donor, Lineage, Cell class and subclass (all cells)	FN1 APCDD1 TIMP3 RYR2	1.67e-05	176	39	4	d2df1e435996c51213e88270af9f928e9e09a6f5
ToppCell	Control-Stromal_mesenchymal-Matrix_Fibroblast-MatrixFB\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	MARCHF4 MCOLN3 RYR2 FRMD3	1.83e-05	180	39	4	08ae0f5d95c45feba68ad99788f7af7ff4c979af
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	FN1 APCDD1 TIMP3 FRMD3	1.91e-05	182	39	4	fbd5e332df73bf7141c822fa67b76367dc962017
ToppCell	Control-Myeloid-MoAM3,_VCAN\|Myeloid / Condition, Lineage and Cell class	TMIGD3 FN1 MCOLN3 RYR3	2.08e-05	186	39	4	0bf16ac48931b62bb3c33d63ff4279654148e293
ToppCell	kidney_cells-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB FN1 APCDD1 TIMP3	2.17e-05	188	39	4	a37edd8f9e4a4e336b5acbb0407d3d275975cee8
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB FN1 APCDD1 TIMP3	2.21e-05	189	39	4	6463890d8dbee4bc198f91628a5f784970de786a
ToppCell	remission-B_memory\|World / disease stage, cell group and cell class	KAT2A TTC21A BTK ZC3H12D	2.26e-05	190	39	4	c3f55f752e47b5a71e111367cdbed4a39ab5cb21
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB FN1 TIMP3 RYR3	2.30e-05	191	39	4	b2c86cde341fe350143658c8a8a4a9edbce3f19b
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB FN1 APCDD1 TIMP3	2.35e-05	192	39	4	bacbaef1f230051335f4433e55db07a161b96b4c
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB FN1 RYR3 PIWIL1	2.35e-05	192	39	4	25cb6cc6cbf8dc20139d938adfc02ed7a8c3dfb6
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Endothelial-endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRB FN1 APCDD1 TIMP3	2.35e-05	192	39	4	042391162df2e3d0027688dd14163c4c6821afe0
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Endothelial\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRB FN1 APCDD1 TIMP3	2.35e-05	192	39	4	71b0bfee0461ff64cef35881db3959c517e9731b
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Endothelial-Endothelial_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PTPRB FN1 APCDD1 TIMP3	2.35e-05	192	39	4	9d53b42cdb537b30233cdfdc08052c8b13a1113f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB FN1 TIMP3 RYR3	2.35e-05	192	39	4	c0e59e642b42c055cf73d029cf54d07d9b719359
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Afferent_/_Efferent_Arteriole_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB FN1 TIMP3 RYR3	2.40e-05	193	39	4	0b328f725f6feba263783eaca60c142e80df90f3
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB FN1 TIMP3 RYR3	2.40e-05	193	39	4	2e72309607902dabe3218888b22a77fe941f3570
ToppCell	Children_(3_yrs)-Mesenchymal-matrix_fibroblast_1_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	FN1 TIMP3 MCOLN3 RYR2	2.40e-05	193	39	4	99525545552b371c86b18b6ea6f4897dc6e9a9ec
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB FN1 TIMP3 RYR3	2.40e-05	193	39	4	52e918884877b6659cdca0496390e440f73694a9
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB FN1 APCDD1 TIMP3	2.40e-05	193	39	4	cc355b2ed6510619cad969ae074126d7c8db784d
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB FN1 TIMP3 RYR3	2.40e-05	193	39	4	287e756d5fd3bd2931c168da24beaa0d02a350ae
ToppCell	Adult-Mesenchymal-matrix_fibroblast_1_cell-D231\|Adult / Lineage, Cell type, age group and donor	FN1 TIMP3 MCOLN3 RYR2	2.40e-05	193	39	4	ef2f456c094e6e3c6ee81e0668c953cb8d0e1c0a
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB FN1 TIMP3 PIWIL1	2.45e-05	194	39	4	cf9cf115dbbb9997f7c303ae07f42f3d80ff9a21
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB FN1 TIMP3 PIWIL1	2.45e-05	194	39	4	ad6c04ad0621689e3bf4c94ccd6e60653bbd02c7
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB FN1 TIMP3 RYR3	2.50e-05	195	39	4	77e47d2e8b3eb7f7c9620369ccaf87581f923bdb
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB FN1 TIMP3 FRMD3	2.55e-05	196	39	4	48b4a9cea97a55190217deaf51bf867608c5a9a7
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-G\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PTPRB FN1 APCDD1 TIMP3	2.55e-05	196	39	4	889c9fed857f64664ca1f47fcec9fecb15ed103c
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB FN1 TIMP3 RYR3	2.55e-05	196	39	4	8ad8efb631164b46f0c082572270188e5ead20bf
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB FN1 TIMP3 RYR3	2.55e-05	196	39	4	9606ea7e42f707e69ea891b3521037613b9675f5
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB FN1 TIMP3 FRMD3	2.55e-05	196	39	4	473980c827443464d08a0be28c53e3536369b12a
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB FN1 APCDD1 TIMP3	2.55e-05	196	39	4	a20a56d8997d6db2a10046c8801c619a379de83c
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB FN1 TIMP3 RYR3	2.55e-05	196	39	4	adee900dcd16dbaba15c58bdcace09ba20214950
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FN1 TIMP3 MCOLN3 RYR2	2.55e-05	196	39	4	cecf82cd5e0a3835d655f5e7478578674a63ce25
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB FN1 TIMP3 RYR3	2.55e-05	196	39	4	22767bcf0095d9eb0cbed7cdc74e4d32d9357e1b
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FN1 TIMP3 MCOLN3 RYR2	2.55e-05	196	39	4	9737a5f006d37b549f281e1863aca558e1e4dc99
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB FN1 TIMP3 FRMD3	2.55e-05	196	39	4	8f2031b1a9232c389517fbf3c29f47f9468b0077
ToppCell	3'-Parenchyma_lung-Mesenchymal-Fibroblastic-fibroblastic_type_2-Alveolar_fibroblasts-Alveolar_fibroblasts_L.2.1.1.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	FN1 TIMP3 MCOLN3 RYR2	2.60e-05	197	39	4	13896ec65ccda0b928c91d41112dc01b480036b7
ToppCell	10x_3'_v2v3-Non-neoplastic-Endothelial-Endothelial_mature-Endo_capilar-G\|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PTPRB FN1 APCDD1 TIMP3	2.65e-05	198	39	4	0a4626b51ba8b52acbaf616f0ced850079cd7149
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic-conventional_dendritic_cell-DC_c2-CD1C\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	LRP1B RYR1 CALHM2 BTK	2.65e-05	198	39	4	d0371e2ca9e25727b35985940f6228f9d8e49727
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Myeloid-Dendritic-conventional_dendritic_cell\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	LRP1B RYR1 CALHM2 BTK	2.65e-05	198	39	4	08ad0bece508bb4f9cc126d94839b5c89ce21ba8
ToppCell	cellseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	FN1 TIMP3 MCOLN3 RYR2	2.65e-05	198	39	4	f1374f7a50244d59c766ac41f44c08c9117407d2
ToppCell	cellseq-Mesenchymal-Fibroblastic-Fibroblastic_2\|cellseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	FN1 TIMP3 MCOLN3 RYR2	2.71e-05	199	39	4	66a79732caf2f04c09b4d9832377aa01ca477677
ToppCell	343B-Fibroblasts-Fibroblast-G\|343B / Donor, Lineage, Cell class and subclass (all cells)	FN1 TIMP3 MCOLN3 RYR2	2.71e-05	199	39	4	f4b6c095cbe7a38b310adc49be4069e4d56e6a66
ToppCell	343B-Fibroblasts-Fibroblast-G-\|343B / Donor, Lineage, Cell class and subclass (all cells)	FN1 TIMP3 MCOLN3 RYR2	2.71e-05	199	39	4	9c6d1c328bfbb6547f4c7bb2a784576a56bd72af
ToppCell	Tracheal-10x3prime_v2-Stromal-Fibroblastic-Fibro_alveolar\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	FN1 TIMP3 MCOLN3 FRMD3	2.76e-05	200	39	4	fda92cb28de99a9c4fe83b7db8145a4beafb0826
ToppCell	Parenchymal-NucSeq-Stromal-Fibroblastic-Fibro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	FN1 TIMP3 MCOLN3 RYR2	2.76e-05	200	39	4	34f52003988ce6329d8deeee1ab875fa77e01e9d
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Ngfr-Inhibitory_Neuron.Chat-Gad1Gad2-Slc17a8.Ngfr_(Globus_Pallidus/Nucleus_Basalis_(GP/NB),_cholinergic)\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ZAR1 MCOLN3 ZC3H12D	5.09e-05	82	39	3	1ed7d7f70f00d6e280cd59c54e710bb724c8b50b
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Ngfr-Inhibitory_Neuron.Chat-Gad1Gad2-Slc17a8.Ngfr_(Globus_Pallidus/Nucleus_Basalis_(GP/NB),_cholinergic)-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ZAR1 MCOLN3 ZC3H12D	5.09e-05	82	39	3	a5d3c5b7012d8ca7418670242d22aad3ed8c5191
ToppCell	Globus_pallidus-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Ngfr\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	ZAR1 MCOLN3 ZC3H12D	5.09e-05	82	39	3	cefd8c6f60ef27fb8823faddca1cf8bbd636f474
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_ALM_Hpgd\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MAS1 RYR1 RYR3	1.82e-04	126	39	3	9b04ca8a46cc30119baf6ef27711a0b2a6b4a0c9
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_anti-infl-Z\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TBC1D8B MAS1 PIWIL1	1.86e-04	127	39	3	fbf7e6bea9991628e98f75c279e2992031dcb8db
ToppCell	PND07-28-samps-Mesenchymal-Mesenchymal_fibroblast\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	PTPRB CALHM2 FRMD3	2.00e-04	130	39	3	6c6a8b77af08b30b424d4f5def37315d3c6e28b2
ToppCell	PND07-28-samps-Mesenchymal-Mesenchymal_fibroblast-mesenchymal_B\|PND07-28-samps / Age Group, Lineage, Cell class and subclass	PTPRB CALHM2 FRMD3	2.00e-04	130	39	3	0706092f6b466585b3b4808b3b982a122d66cfcf
ToppCell	COVID-19-kidney-Epithelial_(EC)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PTPRB LRP1B RYR3	2.14e-04	133	39	3	a8abb6b54862123961ae6defbf251ee6e9575258
ToppCell	frontal_cortex-Neuronal-glutamatergic_neuron-L5_PT\|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MAS1 RYR1 RYR3	2.18e-04	134	39	3	cb676d5bbc468bd3ce1b6712d41c986ee9221ac5
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_VISp_C1ql2_Cdh13\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MAS1 RYR1 RYR3	2.28e-04	136	39	3	1f3000d5f105c87c80f8ae1dd2264bcd7f757a9c
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_PT\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	MAS1 RYR1 RYR3	2.48e-04	140	39	3	7cc891d676555609add6fc7880735d948a2ad801
ToppCell	P03-Hematopoietic\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MCOLN3 RYR1 BTK	2.54e-04	141	39	3	4a856521520ea73291f4730fe94c5de88c2b6f0c
ToppCell	P03-Hematopoietic-Erythroid\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	APCDD1 RYR1 BTK	2.70e-04	144	39	3	2ee6a834860eac7ed004f366ab4fc38c4b80c905
ToppCell	P03-Hematopoietic-Erythroid-enucleate_erythrocyte\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	APCDD1 RYR1 BTK	2.70e-04	144	39	3	9fa63904389f4d7163db22ea85ab721d8f6e8d99
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2\|Hippocampus / BrainAtlas - Mouse McCarroll V32	MAS1 RYR3 PIWIL1	2.86e-04	147	39	3	8f725ff8fb4ced5db2643e80669d3f7945b820ab
ToppCell	P03-Hematopoietic-Immune-immune_cell_unspecified\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MCOLN3 BTK ZC3H12D	2.98e-04	149	39	3	43d756f81d532b5c7f2306e6af9d072d496cbc8e
ToppCell	P03-Hematopoietic-Immune\|P03 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	MCOLN3 BTK ZC3H12D	2.98e-04	149	39	3	1c5a2572741c47246d455c865e8e1677c9f49598
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_aging_sig\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TMIGD3 TBC1D8B PIWIL1	3.10e-04	151	39	3	2f9b3e14c2fa6e2b1976ca6ab2031b63bf5e3e64
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB FN1 TIMP3	3.28e-04	154	39	3	e51a5114f0ec38f997f5b8bbf3a7770f98595474
ToppCell	E15.5-Mesenchymal-developing_mesenchymal_cell-mesenchymal_immature_unknown_1\|E15.5 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	ZNF407 PTPRB FN1	3.28e-04	154	39	3	e65e4636646164610f33f7bbac0d879a3ea55986
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Descending_Vasa_Recta_Endothelial_Cell_prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB FN1 TIMP3	3.28e-04	154	39	3	1899138c096c08d8aee6b1970b7c0081e14c88a8
ToppCell	facs-Pancreas-Exocrine-24m-Hematologic-nan\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 BTK ZC3H12D	3.35e-04	155	39	3	6ade33c274d35ae5531956f70526005d1d5e277b
ToppCell	facs-Pancreas-Exocrine-24m-Hematologic-leukocyte\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 BTK ZC3H12D	3.35e-04	155	39	3	c465a22abc2b9705b6b0fc4753980f790ab8ec5e
ToppCell	facs-Pancreas-Exocrine-24m-Hematologic\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FN1 BTK ZC3H12D	3.35e-04	155	39	3	0dec58d76e3f8cff9d62eaa4adb21a1dc7fd7487
ToppCell	facs-Brain_Myeloid-Cortex_-18m-Myeloid-macrophage\|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MORC4 RYR1 ZC3H12D	3.41e-04	156	39	3	2ba838bc864c2c1767bcab7bb4d790af96b91387
ToppCell	Adult-Mesenchymal-chondrocyte\|Adult / Lineage, Cell type, age group and donor	FN1 TIMP3 RYR2	3.60e-04	159	39	3	3f7305ee76447064b5c846c4f576360a2f7e0b7c
ToppCell	356C-Fibroblasts-Fibroblast-G-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	CATSPERE FN1 RYR2	3.67e-04	160	39	3	0293b244c063a62819690bf22bbc2681f8d15252
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1B RYR2 RYR3	3.67e-04	160	39	3	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	356C-Fibroblasts-Fibroblast-G\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	CATSPERE FN1 RYR2	3.67e-04	160	39	3	3eaae86fa08f7651021316f8e5811bf48055591e
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1B RYR2 RYR3	3.67e-04	160	39	3	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	droplet-Heart-nan-24m-Hematologic-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RYR1 BTK ZC3H12D	3.74e-04	161	39	3	7e60001637ef0f6fc67ef8a36ab80ebb25b0b0ab
ToppCell	severe_influenza-cDC\|severe_influenza / disease group, cell group and cell class (v2)	TIMP3 LRP1B RYR3	3.74e-04	161	39	3	7716315b8bda904b346cea47edc2c0b507a345c2
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB CALHM2 RYR3	3.81e-04	162	39	3	c399b9e4854916a59f5cae2d8dbf19660f8759be
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB CALHM2 RYR3	3.81e-04	162	39	3	a291248b693c771845174393934a782f1d8bd7ce
ToppCell	356C-Lymphocytic-ILC-ILC-3\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	KAT2A TRBV13 RYR1	3.88e-04	163	39	3	2dbdcbc4c187aad3db837d191cc78662a75dd0b5
ToppCell	critical-Myeloid-Mast_cell\|critical / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	PTPRB TIMP3 BTK	4.02e-04	165	39	3	34a1cc6ccd46c059354e8fbde1ac69f202695a4e
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB FN1 TIMP3	4.09e-04	166	39	3	9d4b44eb56ad38c26aed73444edf389abca6bdf6
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TIMP3 RYR2 FRMD3	4.16e-04	167	39	3	7cb1b11e8e24a10115e46ffbb74889e672a7a026
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	TMIGD3 TBC1D8B PIWIL1	4.16e-04	167	39	3	942134bbabe9972fae80cbc4ed4e94da52f55dc3
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell_/_Pericyte-\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TIMP3 RYR2 FRMD3	4.16e-04	167	39	3	bb53a478b5d821d6d82c15bc4ed075b67682457c
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	TIMP3 RYR2 FRMD3	4.16e-04	167	39	3	e228b8373ffd4436e6b944e26d0fadf3ac289b21
ToppCell	NS-critical-d_07-13-Myeloid-Mast_cell\|d_07-13 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	PTPRB TIMP3 BTK	4.16e-04	167	39	3	8a14fd980d8ebe8ef0216221f619d31aaa27ff15
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell__prolif\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB FN1 TIMP3	4.23e-04	168	39	3	37249f38f8f04ec5743097259de67b106ca2b02f
ToppCell	ASK428-Immune-Mast_cell\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	PTPRB TIMP3 BTK	4.23e-04	168	39	3	c399fcb4d1d0be48026c2ecabc34a5935e7adf73
ToppCell	facs-Diaphragm-Limb_Muscle-24m\|Diaphragm / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRP1B RYR2 RYR3	4.31e-04	169	39	3	12bdc709bc000d7f9061ecd9fbd57233eaacb7e2
ToppCell	Nasal_Brush-Epithelial-Basal_1\|Nasal_Brush / Tissue, Lineage and Cell class of Lung Cells from 10X	KAT2A FN1 RYR1	4.53e-04	172	39	3	4483073469001770015526303772fd54906c5d68
ToppCell	Nasal_Brush-Epithelial-Basal_1\|Epithelial / Tissue, Lineage and Cell class of Lung Cells from 10X	KAT2A FN1 RYR1	4.53e-04	172	39	3	58eaadf12366701103a0d1f133462c9495fedc30
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	PTPRB FN1 PIWIL1	4.53e-04	172	39	3	c056d44e2e130ceccadfcdceb192a7f095d779c8
ToppCell	wk_08-11-Mesenchymal-Fibroblast-Airway_fibro\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	MORC4 TIMP3 MCOLN3	4.61e-04	173	39	3	b23b408acc29a667cce104429afef1a6cf2720a5
Drug	2-hydroxyheptanoic acid	RYR1 RYR2 RYR3	3.33e-09	3	35	3	CID002750949
Drug	Ryanodyl 3-(pyridine-3-carboxylate	RYR1 RYR2 RYR3	3.33e-09	3	35	3	CID005748312
Drug	8N3-cADPR	RYR1 RYR2 RYR3	3.33e-09	3	35	3	CID000127713
Drug	2-hydroxycarbazole	RYR1 RYR2 RYR3	3.33e-09	3	35	3	CID000093551
Drug	aminodantrolene	RYR1 RYR2 RYR3	3.33e-09	3	35	3	CID009570289
Drug	cis-diammineplatinum(II	RYR1 RYR2 RYR3	3.33e-09	3	35	3	CID000159790
Drug	SC 38249	RYR1 RYR2 RYR3	1.33e-08	4	35	3	CID000134834
Drug	AC1L1U7A	RYR1 RYR2 RYR3	1.33e-08	4	35	3	CID000035682
Drug	PCB74	RYR1 RYR2 RYR3	1.33e-08	4	35	3	CID000036218
Drug	148504-47-6	RYR1 RYR2 RYR3	1.33e-08	4	35	3	CID006444275
Drug	AC1O528X	RYR1 RYR2 RYR3	6.63e-08	6	35	3	CID006475857
Drug	NSC114784	RYR1 RYR2 RYR3	6.63e-08	6	35	3	CID000419425
Drug	MBED	RYR1 RYR2 RYR3	6.63e-08	6	35	3	CID000129958
Drug	chloro-m-cresol	RYR1 RYR2 RYR3	6.63e-08	6	35	3	CID000012008
Drug	Azumoleno	RYR1 RYR2 RYR3	1.16e-07	7	35	3	CID000056259
Drug	[[(2R,3S,4R)-5-(2-amino-6-oxo-3H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-3,4,5-trihydroxyoxolan-2-yl]methyl hydrogen phosphate	RYR1 RYR2 RYR3	1.16e-07	7	35	3	CID009547999
Drug	Br2BAPTA	RYR1 RYR2 RYR3	1.16e-07	7	35	3	CID003081001
Drug	LOPAC	FN1 RYR1 RYR2 RYR3	1.25e-07	30	35	4	CID000062696
Drug	PCB 95	RYR1 RYR2 RYR3	3.96e-07	10	35	3	CID000038012
Drug	R 478	RYR1 RYR2 RYR3	5.44e-07	11	35	3	CID000084223
Drug	8-amino-cADPR	RYR1 RYR2 RYR3	5.44e-07	11	35	3	CID003081323
Drug	PCB 66	RYR1 RYR2 RYR3	5.44e-07	11	35	3	CID000036185
Drug	Ryanodine	RYR1 RYR2 RYR3	7.25e-07	12	35	3	ctd:D012433
Drug	FPL 64176	RYR1 RYR2 RYR3	1.50e-06	15	35	3	CID000003423
Drug	Gvapspat amide	RYR1 RYR2 RYR3	1.50e-06	15	35	3	CID000125015
Drug	kazinol B	RYR1 RYR2 RYR3	2.23e-06	17	35	3	CID000480869
Drug	5'-adenylyl (beta,gamma-methylene)diphosphonate	RYR1 RYR3	2.30e-06	2	35	2	ctd:C005147
Drug	methylcoumarin	RYR1 RYR2 RYR3	2.67e-06	18	35	3	CID000007092
Drug	AC1L380G	RYR1 RYR2 RYR3	3.17e-06	19	35	3	CID000084698
Drug	AC1MW7VF	RYR1 RYR2 RYR3	3.17e-06	19	35	3	CID000414699
Drug	indo-1/AM	RYR1 RYR2 RYR3	4.34e-06	21	35	3	CID000123918
Drug	tectorigenin	TIMP3 RYR1 RYR2	4.34e-06	21	35	3	CID005281811
Drug	flubendiamide	RYR1 RYR3	6.88e-06	3	35	2	CID011193251
Drug	1,1'-diheptyl-4,4'-bipyridinium	RYR1 RYR3	6.88e-06	3	35	2	CID000080262
Drug	T0702	RYR1 RYR2 RYR3	7.48e-06	25	35	3	CID000005908
Drug	2,4-xylidinothiazoline	RYR1 RYR2 RYR3	1.31e-05	30	35	3	CID000099296
Drug	A-30	RYR1 RYR3	1.37e-05	4	35	2	CID003028528
Drug	Bastadin 10	RYR1 RYR3	1.37e-05	4	35	2	CID009589366
Drug	M-HN	RYR1 RYR2 RYR3	1.45e-05	31	35	3	CID000015450
Drug	M3/M4	RYR1 RYR2 RYR3	1.60e-05	32	35	3	CID000486507
Drug	CNS 1145	RYR1 RYR2 RYR3	1.76e-05	33	35	3	CID000190902
Drug	IHC-64	RYR1 RYR2 RYR3	1.76e-05	33	35	3	CID000162753
Drug	A 68930	RYR1 RYR2	2.29e-05	5	35	2	ctd:C065380
Drug	1,2-dichlorohexafluorocyclobutane	RYR1 RYR2 RYR3	2.49e-05	37	35	3	CID000009643
Drug	4-chloro-m-cresol	RYR1 RYR2 RYR3	2.49e-05	37	35	3	CID000001732
Drug	mag-fura-2	RYR1 RYR2 RYR3	2.49e-05	37	35	3	CID000123839
Drug	AC1L1KF5	LPA RYR1 RYR2 RYR3	2.67e-05	113	35	4	CID000005470
Drug	AC1L98DX	RYR1 RYR2 RYR3	2.71e-05	38	35	3	CID000439957
Drug	NAADP	RYR1 RYR2 RYR3	2.93e-05	39	35	3	CID000123952
Drug	dipyrone	RYR1 RYR2 RYR3	3.16e-05	40	35	3	CID000003110
Drug	Dantrolene	RYR1 RYR2 RYR3	3.41e-05	41	35	3	ctd:D003620
Drug	NSC692750	RYR1 RYR3	3.43e-05	6	35	2	CID000078910
Drug	Pyoverdin	FN1 LPA RYR1	3.94e-05	43	35	3	CID005289234
Drug	escina	RYR1 RYR2 RYR3	4.22e-05	44	35	3	CID006433489
Drug	polyethylenimine	FN1 RYR1 RYR2 RYR3	4.36e-05	128	35	4	CID000009033
Drug	4,4'-dithiodipyridine	RYR1 RYR2 RYR3	4.52e-05	45	35	3	CID000075846
Drug	mag-indo-1	RYR1 RYR3	4.80e-05	7	35	2	CID000131881
Drug	CHEBI:564108	RYR1 RYR3	4.80e-05	7	35	2	CID006400637
Drug	hexadec-11-enal	MAS1 RYR1 BTK	5.49e-05	48	35	3	CID000062073
Drug	ts M	RYR1 RYR2 RYR3	5.49e-05	48	35	3	CID000428025
Drug	lanthanum	LPA RYR1 RYR2 RYR3	5.52e-05	136	35	4	CID000023926
Drug	Trp-Trp	RYR1 RYR2 RYR3	5.84e-05	49	35	3	CID000088656
Drug	AC1L9KQO	RYR1 RYR2 RYR3	5.84e-05	49	35	3	CID000447335
Drug	etridiazole	RYR1 RYR2 RYR3	6.21e-05	50	35	3	CID000017432
Drug	GRGDTP	FN1 LPA	6.39e-05	8	35	2	CID004644096
Drug	lactosyl lysosphingolipid	RYR1 RYR3	8.21e-05	9	35	2	CID006439268
Drug	FLA 365	RYR1 RYR3	8.21e-05	9	35	2	CID000072776
Drug	Cinildipine	RYR1 RYR2 RYR3	8.72e-05	56	35	3	CID000002752
Drug	cysteinylglycine	RYR1 RYR2 RYR3	9.20e-05	57	35	3	CID000065270
Drug	AC1N38XE	RYR1 RYR3	1.03e-04	10	35	2	CID004060965
Drug	lysosphingomyelin	FN1 RYR1 RYR2 RYR3	1.04e-04	160	35	4	CID000005263
Drug	nilvadipine	RYR1 RYR2 RYR3	1.07e-04	60	35	3	CID000004494
Drug	IAA-94	RYR1 RYR2 RYR3	1.13e-04	61	35	3	CID000003667
Drug	thioridazine hydrochloride; Up 200; 10uM; MCF7; HT_HG-U133A	FN1 TIMP3 RYR2 CALHM2	1.17e-04	165	35	4	5227_UP
Drug	lercanidipine	RYR1 RYR2 RYR3	1.24e-04	63	35	3	CID000065866
Drug	2,3,6,2',3',6'-hexachlorobiphenyl	RYR1 RYR2	1.25e-04	11	35	2	ctd:C010498
Drug	tectoridin	RYR1 RYR2	1.25e-04	11	35	2	CID005281810
Drug	succinylcholine	RYR1 RYR2 RYR3	1.30e-04	64	35	3	CID000005314
Drug	pioglitazone	FN1 LPA RYR1 RYR2 RYR3	1.33e-04	326	35	5	CID000004829
Drug	fura 2	RYR1 RYR2 RYR3	1.36e-04	65	35	3	CID000057054
Drug	gallopamil	RYR1 RYR2 RYR3	1.49e-04	67	35	3	CID000001234
Drug	strontium	RYR1 RYR2 RYR3	1.56e-04	68	35	3	CID000104798
Drug	tBuBHQ	RYR1 RYR2 RYR3	1.63e-04	69	35	3	CID000002374
Drug	AC1L2AC7	RYR1 RYR2 RYR3	1.63e-04	69	35	3	CID000068733
Drug	AC1L1D8L	RYR1 RYR2 RYR3	1.77e-04	71	35	3	CID000002241
Drug	flecainide	RYR1 RYR2 RYR3	1.77e-04	71	35	3	CID000003355
Drug	NSC299933	RYR1 RYR3	1.77e-04	13	35	2	CID000431902
Drug	apocynin	FN1 RYR1 RYR2 RYR3	1.85e-04	186	35	4	CID000002214
Drug	CAS 298-57-7	RYR1 RYR2 RYR3	1.92e-04	73	35	3	CID000002761
Drug	ethosuximide	RYR1 RYR2 RYR3	2.00e-04	74	35	3	CID000003291
Drug	bimoclomol	RYR1 RYR3	2.07e-04	14	35	2	CID009576891
Drug	NP-EGTA	RYR1 RYR3	2.07e-04	14	35	2	CID000183793
Drug	Thalidomide [50-35-1]; Up 200; 15.4uM; MCF7; HT_HG-U133A	TIMP3 FBXO21 LRP1B MAS1	2.18e-04	194	35	4	2258_UP
Drug	Harmalol hydrochloride dihydrate [6028-07-5]; Up 200; 14.6uM; PC3; HT_HG-U133A	PTPRB FN1 TBC1D8B MAS1	2.31e-04	197	35	4	5076_UP
Drug	Praziquantel [55268-74-1]; Up 200; 12.8uM; MCF7; HT_HG-U133A	FN1 TIMP3 LRP1B RYR2	2.31e-04	197	35	4	3189_UP
Drug	Nitrarine dihydrochloride [20069-05-0]; Up 200; 10.6uM; PC3; HT_HG-U133A	TIMP3 FBXO21 RYR2 RYR3	2.31e-04	197	35	4	3683_UP
Drug	Sulfamethazine sodium salt [1981-58-4]; Up 200; 13.4uM; MCF7; HT_HG-U133A	FN1 LRP1B MAS1 RYR1	2.31e-04	197	35	4	3940_UP
Drug	nisoldipine	RYR1 RYR2 RYR3	2.34e-04	78	35	3	CID000004499
Drug	Lobelanidine hydrochloride [6112-86-3]; Up 200; 10.6uM; PC3; HT_HG-U133A	PTPRB TBC1D8B FBXO21 RYR2	2.35e-04	198	35	4	5080_UP
Drug	Karakoline [39089-30-0]; Up 200; 10.6uM; MCF7; HT_HG-U133A	FN1 TIMP3 MAS1 RYR1	2.35e-04	198	35	4	3638_UP
Disease	congenital myopathy 1A (implicated_via_orthology)	RYR1 RYR2 RYR3	1.27e-09	3	33	3	DOID:3529 (implicated_via_orthology)
Disease	malignant hyperthermia (implicated_via_orthology)	RYR1 RYR2 RYR3	1.27e-09	3	33	3	DOID:8545 (implicated_via_orthology)
Disease	pulmonary hypertension (biomarker_via_orthology)	RYR1 RYR2 RYR3	9.87e-05	80	33	3	DOID:6432 (biomarker_via_orthology)
Disease	lung adenocarcinoma (is_marker_for)	PTPRB TIMP3 BTK	1.18e-04	85	33	3	DOID:3910 (is_marker_for)
Disease	acute pancreatitis	MORC4 TBC1D8B	1.84e-04	18	33	2	EFO_1000652
Disease	heart disease (implicated_via_orthology)	KAT2A RYR2	8.31e-04	38	33	2	DOID:114 (implicated_via_orthology)
Disease	lung non-small cell carcinoma (is_marker_for)	KAT2A PTPRB TIMP3	8.87e-04	169	33	3	DOID:3908 (is_marker_for)
Disease	alcohol use disorder (implicated_via_orthology)	RYR1 RYR2 RYR3	1.34e-03	195	33	3	DOID:1574 (implicated_via_orthology)

Protein segments in the cluster

Peptide	Gene	Start	Entry
PGLLLWNKHSIYYCY	CATSPERE	456	Q5SY80
KYHPCFWIDGQYLCC	BTK	141	Q06187
ATYKVNYTRWLCYCH	KAT2A	286	Q92830
HKRYGYNCVIYGWDP	FBXO21	511	O94952
KCDHYWPADQDSLYY	PTPRB	1811	P23467
AGYLYWIDCCEYPHI	LRP1B	3141	Q9NZR2
YPIWYRCHRPKYQSA	MAS1	136	P04201
YCFCGWIVLGPYHDK	MCOLN3	426	Q8TDD5
KHYCSPLSYRQEAYW	CALHM2	206	Q9HA72
FHYEYYCPLKEWVAG	FRMD3	571	A2A2Y4
LYYLCRKYSAPSHWC	GSTT4	71	A0A1W2PR19
WEKYVHGVRYQCYCY	FN1	576	P02751
TWEGHYYHYSDPVCK	APCDD1	321	Q8J025
YCYTRDPGVRWEYCN	LPA	201	P08519
YCYTRDPGVRWEYCN	LPA	771	P08519
YLFVSYNKGDWCYCH	EDDM13	131	A0A1B0GTR0
YNKGDWCYCHYCNLE	EDDM13	136	A0A1B0GTR0
GCWSCELCYYKYHVI	MARCHF4	201	Q9P2E8
YGYGCCRPSCYGRYW	KRTAP20-2	46	Q3LI61
LSGYGYACYCPWCYE	KRTAP22-1	26	Q3MIV0
WYGTYLELCGVLHKY	METTL13	31	Q8N6R0
NHYERCWKYYCLPTG	RYR1	2646	P21817
TNHYERCWKYYCLPG	RYR2	2611	Q92736
LTYKLCHIYYNWPGV	PIWIL1	811	Q96J94
ALYVHWPYCEKRCSY	RSAD1	41	Q9HA92
HRTGDKWCIYPTYDY	QARS1	426	P47897
KWCIYPTYDYTHCLC	QARS1	431	P47897
WFCYYNSHPKYRRCS	MORC4	451	Q8TE76
DYYPYHKAGDSCNHW	UHRF1BP1L	361	A0JNW5
KCYPIPRHDTVYWYQ	TRBV13	51	A0A0A6YYD4
TYYSCSYWKGRVPCQ	TBC1D8B	161	Q0IIM8
LLTNHYEQCWKYYCL	RYR3	2506	Q15413
GCASWKWYYPFHYAP	XRN2	556	Q9H0D6
CVPVRCYFHGRWYAD	VWCE	496	Q96DN2
WCLVQICDKYLPGYY	TBC1D10B	466	Q4KMP7
LEPGFNYCRGIYCWH	TTC21A	1026	Q8NDW8
SWQHCPYGKKCTYGI	ZC3H12D	256	A2A288
HTGEKPYRCPWCDYR	ZNF407	1736	Q9C0G0
NAHYKNHPKYWCRGY	TMIGD3	96	P0DMS9
NHPKYWCRGYFRDYC	TMIGD3	101	P0DMS9
YCAPIKGHSYVFWYQ	TRBV16	41	A0A087WV62
HYVTYAKNPNCKWYC	USP32	1526	Q8NFA0
HYACIRQKGGYCSWY	TIMP3	181	P35625
KYGYYHCKDCNIRWE	ZAR1	326	Q86SH2