Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionglutamate-gated calcium ion channel activity

GRIN2A GRIN2C GRIN2D

1.70e-078303GO:0022849
GeneOntologyMolecularFunctionNMDA glutamate receptor activity

GRIN2A GRIN2C GRIN2D

1.70e-078303GO:0004972
GeneOntologyMolecularFunctionglutamate-gated receptor activity

GRIN2A GRIN2C GRIN2D

2.05e-0617303GO:0004970
GeneOntologyMolecularFunctiontransmembrane signaling receptor activity

TMEM63B RRH OR2AG2 LIFR OR2S2 ERBB4 ABCA1 GRIN2A GRIN2C GRIN2D GPR33

2.18e-0613533011GO:0004888
GeneOntologyMolecularFunctionglutamate receptor activity

GRIN2A GRIN2C GRIN2D

8.74e-0627303GO:0008066
GeneOntologyMolecularFunctionsphingolipid floppase activity

ABCA1 ABCA2

1.31e-054302GO:0046623
GeneOntologyMolecularFunctionligand-gated calcium channel activity

GRIN2A GRIN2C GRIN2D

1.34e-0531303GO:0099604
GeneOntologyMolecularFunctionligand-gated monoatomic cation channel activity

TMEM63B GRIN2A GRIN2C GRIN2D

5.51e-05140304GO:0099094
GeneOntologyMolecularFunctiontransmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential

GRIN2A GRIN2C GRIN2D

8.48e-0557303GO:1904315
GeneOntologyMolecularFunctionneurotransmitter receptor activity involved in regulation of postsynaptic membrane potential

GRIN2A GRIN2C GRIN2D

9.88e-0560303GO:0099529
GeneOntologyMolecularFunctiontransmitter-gated channel activity

GRIN2A GRIN2C GRIN2D

1.26e-0465303GO:0022835
GeneOntologyMolecularFunctiontransmitter-gated monoatomic ion channel activity

GRIN2A GRIN2C GRIN2D

1.26e-0465303GO:0022824
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity

TMEM63B GRIN2A GRIN2C GRIN2D

1.90e-04193304GO:0015276
GeneOntologyMolecularFunctionpostsynaptic neurotransmitter receptor activity

GRIN2A GRIN2C GRIN2D

1.92e-0475303GO:0098960
GeneOntologyMolecularFunctionglutamate binding

GRIN2A GRIN2D

1.96e-0414302GO:0016595
GeneOntologyMolecularFunctionligand-gated channel activity

TMEM63B GRIN2A GRIN2C GRIN2D

2.06e-04197304GO:0022834
GeneOntologyMolecularFunctionextracellular ligand-gated monoatomic ion channel activity

GRIN2A GRIN2C GRIN2D

2.08e-0477303GO:0005230
GeneOntologyMolecularFunctionfloppase activity

ABCA1 ABCA2

2.58e-0416302GO:0140328
GeneOntologyMolecularFunctionsphingolipid transporter activity

ABCA1 ABCA2

4.08e-0420302GO:0046624
GeneOntologyMolecularFunctionneurotransmitter receptor activity

GRIN2A GRIN2C GRIN2D

4.48e-04100303GO:0030594
GeneOntologyMolecularFunctionamino acid transmembrane transporter activity

GRIN2A GRIN2C GRIN2D

5.17e-04105303GO:0015171
GeneOntologyMolecularFunctionligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential

GRIN2A GRIN2D

5.90e-0424302GO:0099507
GeneOntologyMolecularFunctionATPase-coupled intramembrane lipid transporter activity

ABCA1 ABCA2

8.05e-0428302GO:0140326
GeneOntologyMolecularFunctioncalcium channel activity

GRIN2A GRIN2C GRIN2D

9.41e-04129303GO:0005262
GeneOntologyMolecularFunctioncalcium ion transmembrane transporter activity

GRIN2A GRIN2C GRIN2D

1.48e-03151303GO:0015085
GeneOntologyMolecularFunctiongated channel activity

TMEM63B GRIN2A GRIN2C GRIN2D

1.49e-03334304GO:0022836
GeneOntologyMolecularFunctionmonoatomic cation channel activity

TMEM63B GRIN2A GRIN2C GRIN2D

1.65e-03343304GO:0005261
GeneOntologyMolecularFunctionABC-type transporter activity

ABCA1 ABCA2

2.46e-0349302GO:0140359
GeneOntologyMolecularFunctionvoltage-gated monoatomic ion channel activity

GRIN2A GRIN2C GRIN2D

2.52e-03182303GO:0005244
GeneOntologyMolecularFunctionvoltage-gated channel activity

GRIN2A GRIN2C GRIN2D

2.60e-03184303GO:0022832
GeneOntologyMolecularFunctionintramembrane lipid transporter activity

ABCA1 ABCA2

2.66e-0351302GO:0140303
GeneOntologyMolecularFunctioncarboxylic acid transmembrane transporter activity

GRIN2A GRIN2C GRIN2D

3.63e-03207303GO:0046943
GeneOntologyMolecularFunctionorganic acid transmembrane transporter activity

GRIN2A GRIN2C GRIN2D

3.68e-03208303GO:0005342
GeneOntologyMolecularFunctionmonoatomic ion channel activity

TMEM63B GRIN2A GRIN2C GRIN2D

4.70e-03459304GO:0005216
GeneOntologyMolecularFunctionamino acid binding

GRIN2A GRIN2D

5.37e-0373302GO:0016597
GeneOntologyMolecularFunctiontransmembrane transporter activity

TMEM63B ABCA1 ABCA2 GRIN2A GRIN2C GRIN2D

7.34e-031180306GO:0022857
GeneOntologyMolecularFunctionchannel activity

TMEM63B GRIN2A GRIN2C GRIN2D

7.53e-03525304GO:0015267
GeneOntologyMolecularFunctionpassive transmembrane transporter activity

TMEM63B GRIN2A GRIN2C GRIN2D

7.58e-03526304GO:0022803
GeneOntologyMolecularFunctionorganic anion transmembrane transporter activity

GRIN2A GRIN2C GRIN2D

9.47e-03293303GO:0008514
GeneOntologyMolecularFunctiontransporter activity

TMEM63B ABCA1 ABCA2 GRIN2A GRIN2C GRIN2D

1.11e-021289306GO:0005215
GeneOntologyMolecularFunctionATPase binding

ABCA1 GRIN2A

1.14e-02108302GO:0051117
GeneOntologyMolecularFunctionATPase-coupled transmembrane transporter activity

ABCA1 ABCA2

1.16e-02109302GO:0042626
GeneOntologyMolecularFunctioninorganic cation transmembrane transporter activity

TMEM63B GRIN2A GRIN2C GRIN2D

1.38e-02627304GO:0022890
GeneOntologyBiologicalProcessexcitatory chemical synaptic transmission

GRIN2A GRIN2C GRIN2D

1.70e-0616313GO:0098976
GeneOntologyBiologicalProcessionotropic glutamate receptor signaling pathway

GRIN2A GRIN2C GRIN2D

8.77e-0627313GO:0035235
GeneOntologyBiologicalProcessdirectional locomotion

GRIN2A GRIN2C

1.31e-054312GO:0033058
GeneOntologyBiologicalProcesssphingolipid translocation

ABCA1 ABCA2

2.18e-055312GO:0099039
GeneOntologyBiologicalProcessligand-gated ion channel signaling pathway

GRIN2A GRIN2C GRIN2D

2.92e-0540313GO:1990806
GeneOntologyBiologicalProcessstartle response

GRIN2A GRIN2C GRIN2D

3.15e-0541313GO:0001964
GeneOntologyBiologicalProcesspositive regulation of excitatory postsynaptic potential

GRIN2A GRIN2C GRIN2D

3.64e-0543313GO:2000463
GeneOntologyBiologicalProcesspositive regulation of synaptic transmission, glutamatergic

GRIN2A GRIN2C GRIN2D

3.64e-0543313GO:0051968
GeneOntologyBiologicalProcessglutamate receptor signaling pathway

GRIN2A GRIN2C GRIN2D

9.44e-0559313GO:0007215
GeneOntologyBiologicalProcessmodulation of excitatory postsynaptic potential

GRIN2A GRIN2C GRIN2D

1.26e-0465313GO:0098815
GeneOntologyBiologicalProcessprotein localization to postsynaptic membrane

ERBB4 GRIN2A GRIN2C

2.09e-0477313GO:1903539
GeneOntologyBiologicalProcessregulation of transmembrane transport

PTPN22 ERBB4 GRIN2A GRIN2C GRIN2D ARL6IP1

2.12e-04589316GO:0034762
GeneOntologyBiologicalProcessprotein localization to postsynapse

ERBB4 GRIN2A GRIN2C

2.34e-0480313GO:0062237
GeneOntologyBiologicalProcessregulation of neuronal synaptic plasticity

GRIN2A GRIN2C GRIN2D

2.60e-0483313GO:0048168
GeneOntologyBiologicalProcessregulation of synaptic transmission, glutamatergic

GRIN2A GRIN2C GRIN2D

3.53e-0492313GO:0051966
GeneOntologyBiologicalProcesspositive regulation of synaptic transmission

ERBB4 GRIN2A GRIN2C GRIN2D

3.93e-04233314GO:0050806
GeneOntologyBiologicalProcessregulation of phospholipid biosynthetic process

ERBB4 ABCA2

4.51e-0421312GO:0071071
GeneOntologyBiologicalProcesssurfactant homeostasis

TMEM63B ERBB4

6.42e-0425312GO:0043129
GeneOntologyBiologicalProcessprotein localization to synapse

ERBB4 GRIN2A GRIN2C

6.77e-04115313GO:0035418
GeneOntologyBiologicalProcessdetection of mechanical stimulus involved in sensory perception of pain

GRIN2A GRIN2D

6.95e-0426312GO:0050966
GeneOntologyBiologicalProcessexcitatory postsynaptic potential

GRIN2A GRIN2C GRIN2D

9.67e-04130313GO:0060079
GeneOntologyBiologicalProcesssynaptic transmission, glutamatergic

GRIN2A GRIN2C GRIN2D

1.01e-03132313GO:0035249
GeneOntologyCellularComponentNMDA selective glutamate receptor complex

GRIN2A GRIN2C GRIN2D

2.47e-079313GO:0017146
GeneOntologyCellularComponentendoplasmic reticulum membrane

GPAT3 PDIA5 ABCA1 GRIN2A GRIN2C GRIN2D ELOVL6 ARL6IP1 ALG9 SYNE2 PHTF1

1.30e-0612933111GO:0005789
GeneOntologyCellularComponentendoplasmic reticulum subcompartment

GPAT3 PDIA5 ABCA1 GRIN2A GRIN2C GRIN2D ELOVL6 ARL6IP1 ALG9 SYNE2 PHTF1

1.36e-0612993111GO:0098827
GeneOntologyCellularComponentnuclear outer membrane-endoplasmic reticulum membrane network

GPAT3 PDIA5 ABCA1 GRIN2A GRIN2C GRIN2D ELOVL6 ARL6IP1 ALG9 SYNE2 PHTF1

1.68e-0613273111GO:0042175
GeneOntologyCellularComponentionotropic glutamate receptor complex

GRIN2A GRIN2C GRIN2D

4.02e-0545313GO:0008328
GeneOntologyCellularComponentneurotransmitter receptor complex

GRIN2A GRIN2C GRIN2D

5.52e-0550313GO:0098878
GeneOntologyCellularComponentpostsynaptic density membrane

ERBB4 GRIN2A GRIN2C GRIN2D

8.23e-05157314GO:0098839
GeneOntologyCellularComponentpostsynaptic specialization membrane

ERBB4 GRIN2A GRIN2C GRIN2D

2.13e-04201314GO:0099634
GeneOntologyCellularComponentreceptor complex

LIFR ERBB4 GRIN2A GRIN2C GRIN2D

1.52e-03581315GO:0043235
GeneOntologyCellularComponentpostsynaptic membrane

ERBB4 GRIN2A GRIN2C GRIN2D

2.89e-03405314GO:0045211
DomainIontro_rcpt

GRIN2A GRIN2C GRIN2D

3.32e-0618313IPR001320
DomainLig_chan

GRIN2A GRIN2C GRIN2D

3.32e-0618313PF00060
DomainLig_chan-Glu_bd

GRIN2A GRIN2C GRIN2D

3.32e-0618313PF10613
DomainPBPe

GRIN2A GRIN2C GRIN2D

3.32e-0618313SM00079
DomainIono_rcpt_met

GRIN2A GRIN2C GRIN2D

3.32e-0618313IPR001508
DomainGlu/Gly-bd

GRIN2A GRIN2C GRIN2D

3.32e-0618313IPR019594
DomainLig_chan-Glu_bd

GRIN2A GRIN2C GRIN2D

3.32e-0618313SM00918
DomainNMDAR2_C

GRIN2A GRIN2C

7.99e-063312PF10565
DomainNMDAR2_C

GRIN2A GRIN2C

7.99e-063312IPR018884
DomainANF_receptor

GRIN2A GRIN2C GRIN2D

3.10e-0537313PF01094
DomainANF_lig-bd_rcpt

GRIN2A GRIN2C GRIN2D

3.10e-0537313IPR001828
DomainPeripla_BP_I

GRIN2A GRIN2C GRIN2D

3.63e-0539313IPR028082
DomainABC_A

ABCA1 ABCA2

1.74e-0412312IPR026082
DomainABC_transporter_CS

ABCA1 ABCA2

2.20e-0342312IPR017871
DomainABC_TRANSPORTER_2

ABCA1 ABCA2

2.87e-0348312PS50893
DomainABC_tran

ABCA1 ABCA2

2.87e-0348312PF00005
DomainABC_TRANSPORTER_1

ABCA1 ABCA2

2.99e-0349312PS00211
DomainABC_transporter-like

ABCA1 ABCA2

3.11e-0350312IPR003439
PathwayREACTOME_ASSEMBLY_AND_CELL_SURFACE_PRESENTATION_OF_NMDA_RECEPTORS

GRIN2A GRIN2C GRIN2D

4.92e-085253MM15655
PathwayKEGG_MEDICUS_REFERENCE_TRANSPORT_OF_CALCIUM

GRIN2A GRIN2C GRIN2D

4.92e-085253M47667
PathwayREACTOME_LONG_TERM_POTENTIATION

ERBB4 GRIN2A GRIN2C GRIN2D

6.66e-0823254M27949
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_PDYN_TO_TRANSPORT_OF_CALCIUM

GRIN2A GRIN2C GRIN2D

9.82e-086253M47668
PathwayKEGG_MEDICUS_REFERENCE_CA2_ENTRY_LIGAND_GATED_CA2_CHANNEL

GRIN2A GRIN2C GRIN2D

1.07e-0612253M47953
PathwayWP_NOCGMPPKG_MEDIATED_NEUROPROTECTION

GRIN2A GRIN2C GRIN2D GUCY1B2

1.30e-0647254M39531
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_ABETA_TO_TRANSPORT_OF_CALCIUM

GRIN2A GRIN2C GRIN2D

2.21e-0615253M47691
PathwayWP_PHOSPHODIESTERASES_IN_NEURONAL_FUNCTION

GRIN2A GRIN2C GRIN2D GUCY1B2

2.47e-0655254M39763
PathwayKEGG_MEDICUS_VARIANT_SCRAPIE_CONFORMATION_PRPSC_TO_TRANSPORT_OF_CALCIUM

GRIN2A GRIN2C GRIN2D

3.95e-0618253M47761
PathwayWP_NRXN1_DELETION_SYNDROME

GRIN2A GRIN2C GRIN2D

3.95e-0618253M48098
PathwayKEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_TRANSPORT_OF_CALCIUM

GRIN2A GRIN2C GRIN2D

4.69e-0619253M47677
PathwayBIOCARTA_NOS1_PATHWAY

GRIN2A GRIN2C GRIN2D

5.51e-0620253MM1445
PathwayREACTOME_SYNAPTIC_ADHESION_LIKE_MOLECULES

GRIN2A GRIN2C GRIN2D

5.51e-0620253MM15485
PathwayREACTOME_SYNAPTIC_ADHESION_LIKE_MOLECULES

GRIN2A GRIN2C GRIN2D

6.42e-0621253M27736
PathwayBIOCARTA_NOS1_PATHWAY

GRIN2A GRIN2C GRIN2D

6.42e-0621253M11650
PathwayREACTOME_UNBLOCKING_OF_NMDA_RECEPTORS_GLUTAMATE_BINDING_AND_ACTIVATION

GRIN2A GRIN2C GRIN2D

6.42e-0621253M838
PathwayREACTOME_NEGATIVE_REGULATION_OF_NMDA_RECEPTOR_MEDIATED_NEURONAL_TRANSMISSION

GRIN2A GRIN2C GRIN2D

6.42e-0621253M27944
PathwayREACTOME_UNBLOCKING_OF_NMDA_RECEPTORS_GLUTAMATE_BINDING_AND_ACTIVATION

GRIN2A GRIN2C GRIN2D

7.42e-0622253MM15104
PathwayREACTOME_ACTIVATION_OF_NMDA_RECEPTORS_AND_POSTSYNAPTIC_EVENTS

ERBB4 GRIN2A GRIN2C GRIN2D

2.11e-0594254M2843
PathwayWP_DISRUPTION_OF_POSTSYNAPTIC_SIGNALING_BY_CNV

GRIN2A GRIN2C GRIN2D

2.60e-0533253M39875
PathwayREACTOME_ACTIVATION_OF_NMDA_RECEPTORS_AND_POSTSYNAPTIC_EVENTS

GRIN2A GRIN2C GRIN2D

3.11e-0535253MM15109
PathwayWP_VITAMIN_DSENSITIVE_CALCIUM_SIGNALING_IN_DEPRESSION

GRIN2A GRIN2C GRIN2D

3.38e-0536253M39831
PathwayREACTOME_ASSEMBLY_AND_CELL_SURFACE_PRESENTATION_OF_NMDA_RECEPTORS

GRIN2A GRIN2C GRIN2D

6.22e-0544253M27934
PathwayWP_SYNAPTIC_SIGNALING_ASSOCIATED_WITH_AUTISM_SPECTRUM_DISORDER

GRIN2A GRIN2C GRIN2D

9.14e-0550253M39822
PathwayKEGG_AMYOTROPHIC_LATERAL_SCLEROSIS_ALS

GRIN2A GRIN2C GRIN2D

1.09e-0453253M3812
PathwayREACTOME_NEUREXINS_AND_NEUROLIGINS

GRIN2A GRIN2C GRIN2D

1.28e-0456253M27616
PathwayREACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES

GRIN2A GRIN2C GRIN2D

2.19e-0467253MM15327
PathwayKEGG_LONG_TERM_POTENTIATION

GRIN2A GRIN2C GRIN2D

2.49e-0470253M3115
PathwayKEGG_CALCIUM_SIGNALING_PATHWAY

ERBB4 GRIN2A GRIN2C GRIN2D

2.53e-04178254M2890
PathwayWP_ALZHEIMERS_DISEASE

GRIN2A GRIN2C GRIN2D

2.94e-0474253MM15962
PathwayREACTOME_NEUROTRANSMITTER_RECEPTORS_AND_POSTSYNAPTIC_SIGNAL_TRANSMISSION

ERBB4 GRIN2A GRIN2C GRIN2D

4.32e-04205254M752
PathwayREACTOME_PROTEIN_PROTEIN_INTERACTIONS_AT_SYNAPSES

GRIN2A GRIN2C GRIN2D

4.73e-0487253M27617
PathwayWP_MTHFR_DEFICIENCY

GRIN2A GRIN2D

8.14e-0424252M39755
PathwayREACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES

ERBB4 GRIN2A GRIN2C GRIN2D

1.21e-03270254M15514
PathwayWP_NEUROINFLAMMATION_AND_GLUTAMATERGIC_SIGNALING

GRIN2A GRIN2C GRIN2D

1.88e-03140253M42572
PathwayREACTOME_NEUROTRANSMITTER_RECEPTORS_AND_POSTSYNAPTIC_SIGNAL_TRANSMISSION

GRIN2A GRIN2C GRIN2D

2.04e-03144253MM14501
PathwayKEGG_ABC_TRANSPORTERS

ABCA1 ABCA2

2.73e-0344252M11911
PathwayKEGG_ALZHEIMERS_DISEASE

GRIN2A GRIN2C GRIN2D

3.05e-03166253M16024
PathwayWP_RETT_SYNDROME

GRIN2A SYNE2

3.24e-0348252M39759
PathwayWP_GPCRS_CLASS_A_RHODOPSINLIKE

RRH OR2AG2 GPR33

4.20e-03186253MM15994
PathwayREACTOME_NEURONAL_SYSTEM

ERBB4 GRIN2A GRIN2C GRIN2D

5.54e-03411254M735
PathwayREACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES

GRIN2A GRIN2C GRIN2D

5.96e-03211253MM14502
PathwayWP_MELANOMA

ERBB4 GRIN2A

6.40e-0368252M39811
Pubmed

Auditory pathway and auditory brainstem response in mice lacking NMDA receptor epsilon 1 and epsilon 4 subunits.

GRIN2A GRIN2C GRIN2D

6.41e-1033139718984
Pubmed

Localization of the human NMDAR2D receptor subunit gene (GRIN2D) to 19q13.1-qter, the NMDAR2A subunit gene to 16p13.2 (GRIN2A), and the NMDAR2C subunit gene (GRIN2C) to 17q24-q25 using somatic cell hybrid and radiation hybrid mapping panels.

GRIN2A GRIN2C GRIN2D

6.41e-1033139480759
Pubmed

Functional correlation of NMDA receptor epsilon subunits expression with the properties of single-channel and synaptic currents in the developing cerebellum.

GRIN2A GRIN2C GRIN2D

2.56e-0943138699248
Pubmed

Role of the carboxy-terminal region of the GluR epsilon2 subunit in synaptic localization of the NMDA receptor channel.

GRIN2A GRIN2C GRIN2D

2.56e-0943139768843
Pubmed

Structural insights into assembly and function of GluN1-2C, GluN1-2A-2C, and GluN1-2D NMDARs.

GRIN2A GRIN2C GRIN2D

2.56e-09431336309015
Pubmed

Positive Allosteric Modulators of GluN2A-Containing NMDARs with Distinct Modes of Action and Impacts on Circuit Function.

GRIN2A GRIN2C GRIN2D

6.40e-09531326875626
Pubmed

Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.

GRIN2A GRIN2C GRIN2D

6.40e-09531326919761
Pubmed

Distinct distributions of five NMDA receptor channel subunit mRNAs in the brainstem.

GRIN2A GRIN2C GRIN2D

6.40e-0953137518475
Pubmed

Distinct spatiotemporal expressions of five NMDA receptor channel subunit mRNAs in the cerebellum.

GRIN2A GRIN2C GRIN2D

6.40e-0953137518474
Pubmed

Synapse-selective impairment of NMDA receptor functions in mice lacking NMDA receptor epsilon 1 or epsilon 2 subunit.

GRIN2A GRIN2C GRIN2D

6.40e-0953139147327
Pubmed

Differential distributions of the NMDA receptor channel subunit mRNAs in the mouse retina.

GRIN2A GRIN2C GRIN2D

6.40e-0953137510577
Pubmed

Distinct gene expression of the N-methyl-D-aspartate receptor channel subunit in peripheral neurons of the mouse sensory ganglia and adrenal gland.

GRIN2A GRIN2C GRIN2D

6.40e-0953138015722
Pubmed

Inducible and reversible NR1 knockout reveals crucial role of the NMDA receptor in preserving remote memories in the brain.

GRIN2A GRIN2C GRIN2D

6.40e-09531315003177
Pubmed

GABAA, GABAC, and NMDA receptor subunit expression in the suprachiasmatic nucleus and other brain regions.

GRIN2A GRIN2C GRIN2D

6.40e-0953137723623
Pubmed

Modification of NMDA receptor channels and synaptic transmission by targeted disruption of the NR2C gene.

GRIN2A GRIN2C GRIN2D

6.40e-0953138756432
Pubmed

Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor.

GRIN2A GRIN2C GRIN2D

6.40e-09531312082569
Pubmed

Heterozygous deletion of NR1 subunit of the NMDA receptor alters ethanol-related behaviors and regional expression of NR2 subunits in the brain.

GRIN2A GRIN2C GRIN2D

6.40e-09531321945132
Pubmed

Differential interaction of NMDA receptor subtypes with the post-synaptic density-95 family of membrane associated guanylate kinase proteins.

GRIN2A GRIN2C GRIN2D

6.40e-09531318233995
Pubmed

Roles of the glutamate receptor epsilon2 and delta2 subunits in the potentiation and prepulse inhibition of the acoustic startle reflex.

GRIN2A GRIN2C GRIN2D

6.40e-09531311488959
Pubmed

Developmental changes in distribution of NMDA receptor channel subunit mRNAs.

GRIN2A GRIN2C GRIN2D

6.40e-0953131493227
Pubmed

N-methyl-D-aspartic acid receptor structure and function.

GRIN2A GRIN2C GRIN2D

6.40e-0953138036251
Pubmed

NMDA receptor activation by HIV-Tat protein is clade dependent.

GRIN2A GRIN2C GRIN2D

6.40e-09531319020013
Pubmed

Distinct spatiotemporal distributions of the N-methyl-D-aspartate receptor channel subunit mRNAs in the mouse cervical cord.

GRIN2A GRIN2C GRIN2D

6.40e-0953137929904
Pubmed

Cortical consequences of HIV-1 Tat exposure in rats are enhanced by chronic cocaine.

GRIN2A GRIN2C GRIN2D

1.28e-08631325760043
Pubmed

A role for spermine oxidase as a mediator of reactive oxygen species production in HIV-Tat-induced neuronal toxicity.

GRIN2A GRIN2C GRIN2D

1.28e-08631323665428
Pubmed

Altered gene expression of the N-methyl-D-aspartate receptor channel subunits in Purkinje cells of the staggerer mutant mouse.

GRIN2A GRIN2C GRIN2D

1.28e-0863138996814
Pubmed

Importance of the intracellular domain of NR2 subunits for NMDA receptor function in vivo.

GRIN2A GRIN2C GRIN2D

1.28e-0863139458051
Pubmed

NMDA receptor GluRepsilon/NR2 subunits are essential for postsynaptic localization and protein stability of GluRzeta1/NR1 subunit.

GRIN2A GRIN2C GRIN2D

1.28e-08631315317856
Pubmed

Early onset of NMDA receptor GluR epsilon 1 (NR2A) expression and its abundant postsynaptic localization in developing motoneurons of the mouse hypoglossal nucleus.

GRIN2A GRIN2C GRIN2D

2.24e-08731312103442
Pubmed

Human immunodeficiency virus-1 protein Tat induces excitotoxic loss of presynaptic terminals in hippocampal cultures.

GRIN2A GRIN2C GRIN2D

2.24e-08731323267846
Pubmed

Human immunodeficiency virus protein Tat induces synapse loss via a reversible process that is distinct from cell death.

GRIN2A GRIN2C GRIN2D

2.24e-08731319036954
Pubmed

Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia.

GRIN2A GRIN2C GRIN2D

2.24e-08731322833210
Pubmed

HIV immune complexes prevent excitotoxicity by interaction with NMDA receptors.

GRIN2A GRIN2C GRIN2D

2.24e-08731322940423
Pubmed

Direct cytotoxicity of HIV-1 envelope protein gp120 on human NT neurons.

GRIN2A GRIN2C GRIN2D

3.58e-0883138804048
Pubmed

HIV-tat induces formation of an LRP-PSD-95- NMDAR-nNOS complex that promotes apoptosis in neurons and astrocytes.

GRIN2A GRIN2C GRIN2D

3.58e-08831317360663
Pubmed

Human brain N-methyl-D-aspartate receptors regulating noradrenaline release are positively modulated by HIV-1 coat protein gp120.

GRIN2A GRIN2C GRIN2D

3.58e-0883138724036
Pubmed

The coat protein gp120 of HIV-1 inhibits astrocyte uptake of excitatory amino acids via macrophage arachidonic acid.

GRIN2A GRIN2C GRIN2D

3.58e-0883138845955
Pubmed

Prevention of HIV-1 gp120-induced neuronal damage in the central nervous system of transgenic mice by the NMDA receptor antagonist memantine.

GRIN2A GRIN2C GRIN2D

3.58e-0883138822372
Pubmed

Activation of extrasynaptic, but not synaptic, NMDA receptors modifies amyloid precursor protein expression pattern and increases amyloid-ß production.

GRIN2A GRIN2C GRIN2D

3.58e-08831321106831
Pubmed

HIV-1 envelope proteins gp120 and gp160 potentiate NMDA-induced [Ca2+]i increase, alter [Ca2+]i homeostasis and induce neurotoxicity in human embryonic neurons.

GRIN2A GRIN2C GRIN2D

3.58e-0883138563977
Pubmed

HIV-1 gp120-induced neurotoxicity to midbrain dopamine cultures.

GRIN2A GRIN2C GRIN2D

3.58e-0883138821747
Pubmed

Glucocorticoid modulation of gp120-induced effects on calcium-dependent degenerative events in primary hippocampal and cortical cultures.

GRIN2A GRIN2C GRIN2D

3.58e-08831310448428
Pubmed

Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity.

GRIN2A GRIN2C GRIN2D

3.58e-0883137695237
Pubmed

Central nervous system expression of HIV-1 Gp120 activates the hypothalamic-pituitary-adrenal axis: evidence for involvement of NMDA receptors and nitric oxide synthase.

GRIN2A GRIN2C GRIN2D

3.58e-0883138955056
Pubmed

Evidence of HIV type 1 glycoprotein 120 binding to recombinant N-methyl-D-aspartate receptor subunits expressed in a baculovirus system.

GRIN2A GRIN2C GRIN2D

3.58e-08831310555109
Pubmed

Fyn-mediated phosphorylation of NR2B Tyr-1336 controls calpain-mediated NR2B cleavage in neurons and heterologous systems.

GRIN2A GRIN2C GRIN2D

5.37e-08931317526495
Pubmed

D1/NMDA receptors and concurrent methamphetamine+ HIV-1 Tat neurotoxicity.

GRIN2A GRIN2C GRIN2D

5.37e-08931322552781
Pubmed

Activation of cannabinoid type 2 receptors inhibits HIV-1 envelope glycoprotein gp120-induced synapse loss.

GRIN2A GRIN2C GRIN2D

5.37e-08931321670103
Pubmed

Human immunodeficiency virus type 1 clade B and C gp120 differentially induce neurotoxin arachidonic acid in human astrocytes: implications for neuroAIDS.

GRIN2A GRIN2C GRIN2D

5.37e-08931321491143
Pubmed

Maternal stress produces learning deficits associated with impairment of NMDA receptor-mediated synaptic plasticity.

GRIN2A GRIN2C GRIN2D

5.37e-08931316554481
Pubmed

PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A.

GRIN2A GRIN2C GRIN2D

5.37e-0893139892651
Pubmed

N-methyl-D-aspartate receptors mediate the phosphorylation and desensitization of muscarinic receptors in cerebellar granule neurons.

GRIN2A GRIN2C GRIN2D

7.66e-081031319332541
Pubmed

Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of nitric oxide and cyclooxygenase.

GRIN2A GRIN2C GRIN2D

1.05e-07113138581564
Pubmed

HIV-1 Tat-mediated apoptosis in human blood-retinal barrier-associated cells.

GRIN2A GRIN2C GRIN2D

1.05e-071131324739951
Pubmed

CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins.

GRIN2A GRIN2C GRIN2D

1.05e-07113139647694
Pubmed

Effects of SDF-1alpha and gp120IIIB on apoptotic pathways in SK-N-SH neuroblastoma cells.

GRIN2A GRIN2C GRIN2D

1.05e-071131316481105
Pubmed

Activation of peripheral NMDA receptors contributes to human pain and rat afferent discharges evoked by injection of glutamate into the masseter muscle.

GRIN2A GRIN2C GRIN2D

1.40e-071231312815021
Pubmed

Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102.

GRIN2A GRIN2C GRIN2D

1.40e-071231311937501
Pubmed

Developmental rearrangements of cortical glutamate-NMDA receptor binding sites in late human gestation.

GRIN2A GRIN2C GRIN2D

1.40e-07123138665664
Pubmed

Ethanol potentiates HIV-1 gp120-induced apoptosis in human neurons via both the death receptor and NMDA receptor pathways.

GRIN2A GRIN2C GRIN2D

2.32e-071431315749123
Pubmed

Neurotoxicity of human immunodeficiency virus-1: viral proteins and axonal transport.

GRIN2A GRIN2C GRIN2D

2.90e-071531321948112
Pubmed

Neuronal interleukin-16 (NIL-16): a dual function PDZ domain protein.

GRIN2A GRIN2C GRIN2D

2.90e-071531310479680
Pubmed

Chemokine co-receptor CCR5/CXCR4-dependent modulation of Kv2.1 channel confers acute neuroprotection to HIV-1 glycoprotein gp120 exposure.

GRIN2A GRIN2C GRIN2D

4.32e-071731324086760
Pubmed

Gene structure and chromosomal localization of the mouse NMDA receptor channel subunits.

GRIN2A GRIN2C GRIN2D

5.18e-07183139011744
Pubmed

Attenuation of focal cerebral infarct in mice lacking NMDA receptor subunit NR2C.

GRIN2A GRIN2C

7.69e-0723129512392
Pubmed

NMDA receptor subtypes at autaptic synapses of cerebellar granule neurons.

GRIN2A GRIN2C

7.69e-07231216885526
Pubmed

Conditioned eyeblink response is impaired in mutant mice lacking NMDA receptor subunit NR2A.

GRIN2A GRIN2C

7.69e-0723129427357
Pubmed

In the Telencephalon, GluN2C NMDA Receptor Subunit mRNA is Predominately Expressed in Glial Cells and GluN2D mRNA in Interneurons.

GRIN2C GRIN2D

7.69e-07231229651654
Pubmed

NMDA receptor 2 (NR2) C-terminal control of NR open probability regulates synaptic transmission and plasticity at a cerebellar synapse.

GRIN2A GRIN2C

7.69e-07231212427824
Pubmed

Differential effect of NMDA receptor GluN2C and GluN2D subunit ablation on behavior and channel blocker-induced schizophrenia phenotypes.

GRIN2C GRIN2D

7.69e-07231231110197
Pubmed

Essential role of NMDA receptor channel ε4 subunit (GluN2D) in the effects of phencyclidine, but not methamphetamine.

GRIN2A GRIN2D

7.69e-07231221060893
Pubmed

Functional plasticity of the N-methyl-d-aspartate receptor in differentiating human erythroid precursor cells.

GRIN2A GRIN2C

7.69e-07231225788577
Pubmed

ABCA2 is a strong genetic risk factor for early-onset Alzheimer's disease.

ABCA1 ABCA2

7.69e-07231215649702
Pubmed

Target-cell-specific left-right asymmetry of NMDA receptor content in schaffer collateral synapses in epsilon1/NR2A knock-out mice.

GRIN2A GRIN2D

7.69e-07231216207881
Pubmed

Involvement of N-methyl-D-aspartate-type glutamate receptor epsilon1 and epsilon4 subunits in tonic inflammatory pain and neuropathic pain.

GRIN2A GRIN2D

7.69e-07231216189474
Pubmed

Cloning of two novel ABC transporters mapping on human chromosome 9.

ABCA1 ABCA2

7.69e-0723128088782
Pubmed

N-methyl-D-aspartate receptor subtype 2C is not involved in circadian oscillation or photoic entrainment of the biological clock in mice.

GRIN2A GRIN2C

7.69e-07231210972963
Pubmed

Characterization of the glutamatergic system for induction and maintenance of allodynia.

GRIN2A GRIN2D

7.69e-07231211259776
Pubmed

Rare loss of function mutations in N-methyl-D-aspartate glutamate receptors and their contributions to schizophrenia susceptibility.

GRIN2C GRIN2D

7.69e-07231229317596
Pubmed

Absence of prostaglandin E2-induced hyperalgesia in NMDA receptor epsilon subunit knockout mice.

GRIN2A GRIN2D

7.69e-0723129113374
Pubmed

Characterization of nociceptin/orphanin FQ-induced pain responses in conscious mice: neonatal capsaicin treatment and N-methyl-D-aspartate receptor GluRepsilon subunit knockout mice.

GRIN2A GRIN2D

7.69e-07231210771345
Pubmed

Nitric oxide (NO) serves as a retrograde messenger to activate neuronal NO synthase in the spinal cord via NMDA receptors.

GRIN2A GRIN2D

7.69e-07231217548218
Pubmed

Enhanced function of NR2C/2D-containing NMDA receptor in the nucleus accumbens contributes to peripheral nerve injury-induced neuropathic pain and depression in mice.

GRIN2C GRIN2D

7.69e-07231235057644
Pubmed

Motor discoordination results from combined gene disruption of the NMDA receptor NR2A and NR2C subunits, but not from single disruption of the NR2A or NR2C subunit.

GRIN2A GRIN2C

7.69e-0723128987814
Pubmed

NMDA GluN2C/2D receptors contribute to synaptic regulation and plasticity in the anterior cingulate cortex of adult mice.

GRIN2C GRIN2D

7.69e-07231233766086
Pubmed

Characterization of N-methyl-D-aspartate receptor subunits responsible for postoperative pain.

GRIN2A GRIN2D

7.69e-07231215496298
Pubmed

Cloning, characterization and tissue distribution of the rat ATP-binding cassette (ABC) transporter ABC2/ABCA2.

ABCA1 ABCA2

7.69e-07231210970803
Pubmed

NMDA receptor subunits GluRepsilon1, GluRepsilon3 and GluRzeta1 are enriched at the mossy fibre-granule cell synapse in the adult mouse cerebellum.

GRIN2A GRIN2C

7.69e-07231211422443
Pubmed

ABC transporters: from microorganisms to man.

ABCA1 ABCA2

7.69e-0723121282354
Pubmed

NMDA receptors containing GluN2C and GluN2D subunits have opposing roles in modulating neuronal oscillations; potential mechanism for bidirectional feedback.

GRIN2C GRIN2D

7.69e-07231231786200
Pubmed

The human immunodeficiency virus coat protein gp120 promotes forward trafficking and surface clustering of NMDA receptors in membrane microdomains.

GRIN2A GRIN2C GRIN2D

8.44e-072131322114277
Pubmed

Glutamate can act as a signaling molecule in mouse preimplantation embryos†.

GRIN2A GRIN2C GRIN2D

1.28e-062431335746896
Pubmed

Mechanisms of prionSc- and HIV-1 gp120 induced neuronal cell death.

GRIN2A GRIN2C GRIN2D

1.64e-06263139745929
Pubmed

Long-term NR2B expression in the cerebellum alters granule cell development and leads to NR2A down-regulation and motor deficits.

GRIN2A GRIN2C

2.31e-06331215519237
Pubmed

Cocaine preference and neuroadaptations are maintained by astrocytic NMDA receptors in the nucleus accumbens.

GRIN2C GRIN2D

2.31e-06331235867797
Pubmed

Pilot study of iPS-derived neural cells to examine biologic effects of alcohol on human neurons in vitro.

GRIN2A GRIN2D

2.31e-06331222486492
Pubmed

Cloning and expression of the epsilon 4 subunit of the NMDA receptor channel.

GRIN2A GRIN2D

2.31e-0633121385220
Pubmed

Dual regulation of NR2B and NR2C expression by NMDA receptor activation in mouse cerebellar granule cell cultures.

GRIN2A GRIN2C

2.31e-06331218685090
Pubmed

Signal pathways coupled to activation of neuronal nitric oxide synthase in the spinal cord by nociceptin/orphanin FQ.

GRIN2A GRIN2D

2.31e-06331217350656
Pubmed

Chromosomal localization of the epsilon 1, epsilon 3 and zeta 1 subunit genes of the human NMDA receptor channel.

GRIN2A GRIN2C

2.31e-0633128267632
InteractionDLG2 interactions

ERBB4 ABCA1 GRIN2A GRIN2D

5.87e-0683294int:DLG2
InteractionDLG3 interactions

ERBB4 ABCA1 GRIN2A GRIN2C

3.57e-05131294int:DLG3
Cytoband4q25

RRH ELOVL6

9.49e-04673124q25
CytobandEnsembl 112 genes in cytogenetic band chr4q25

RRH ELOVL6

1.74e-0391312chr4q25
GeneFamilyGlutamate ionotropic receptor NMDA type subunits

GRIN2A GRIN2C GRIN2D

4.04e-0872031201
GeneFamilyATP binding cassette subfamily A

ABCA1 ABCA2

1.05e-0414202805
GeneFamilyOlfactory receptors, family 2

OR2AG2 OR2S2

6.84e-03113202149
ToppCellChildren_(3_yrs)-Immune-natural_killer_cell-D032|Children_(3_yrs) / Lineage, Cell type, age group and donor

STK10 PTPN22 ABCA2 ELOVL6

5.47e-0617430433d6b81f31bfcb9c4b30206d88e20b9a94fba4a2
ToppCellAdult-Immune-natural_killer_cell-D175|Adult / Lineage, Cell type, age group and donor

STK10 PTPN22 ABCA2 SYNE2

6.26e-06180304fc59e28f39e7d4fb1bcc7205202cf39224b70d7b
ToppCellAdult-Immune-natural_killer_cell|Adult / Lineage, Cell type, age group and donor

STK10 PTPN22 ABCA2 SYNE2

7.91e-06191304758ec27e47d7662a5175305e98a1506c6859dbf7
ToppCellChildren_(3_yrs)-Immune-natural_killer_cell|Children_(3_yrs) / Lineage, Cell type, age group and donor

STK10 PTPN22 ABCA2 ELOVL6

8.24e-061933041cb666375bc4e1b11a146d20896c9b5ae6fd0887
ToppCellChildren_(3_yrs)-Immune-T_lymphocyte-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

STK10 PTPN22 ELOVL6 SYNE2

8.41e-061943043d6f2d190dd50804afea299957cc44c2bb756134
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Immune-Myeloid-Granulocytic-Mast_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

GPAT3 STK10 PTPN22

1.67e-04160303fe9970c160159b35f6599ed13c89cfb49264d554
ToppCellfacs-Pancreas-Exocrine-18m-Hematologic|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STK10 PTPN22 GPR33

1.70e-04161303f5821f551cf5c64c9f75cdb723492c87aac1ece0
ToppCellfacs-Pancreas-Exocrine-18m-Hematologic-leukocyte|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STK10 PTPN22 GPR33

1.70e-0416130358a32a1033f379579697bda1bbf047a088e4a34f
ToppCellfacs-Pancreas-Exocrine-18m-Hematologic-nan|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STK10 PTPN22 GPR33

1.70e-0416130316f77e7a5444d2f2b210362816cd7a07b9b42af6
ToppCellfacs-Lung-ENDOMUCIN-18m-Lymphocytic-NK_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STK10 PTPN22 PHTF1

1.73e-041623035731f9514434296132df4bc86f78ce87b07cdeca
ToppCellfacs-Lung-ENDOMUCIN-18m-Lymphocytic-Natural_Killer|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STK10 PTPN22 PHTF1

1.73e-041623030321fc954ae4ad67ca438cbbc84632562d222188
ToppCell10x_3'_v3-tissue-resident_(10x_3'_v3)-lymphocytic-T_lymphocytic-effector_CD4-positive,_alpha-beta_T_cell|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

ELOVL6 GUCY1B2 SYNE2

1.93e-0416830307be11b6f0f37106e219692db5795c6dd32807c9
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D231|Adult / Lineage, Cell type, age group and donor

LIFR ERBB4 SYNE2

2.00e-04170303269dee5abca9f6aa079f116f0d8f1d198604d9d4
ToppCellSevere-Lymphoid-T-|Severe / Condition, Lineage, Cell class and cell subclass

ELOVL6 SPSB3 SYNE2

2.00e-041703035788e1158fde036937d41708e9db3222ca351eb1
ToppCell3'-Child09-12-SmallIntestine-Hematopoietic-T_cells-TRGV4_gdT|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PTPN22 ELOVL6 PHTF1

2.00e-0417030365c7ed586e7615203a59999549892ed466a89502
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-Lgr5+_undifferentiated_cell_(Distal)|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

GPAT3 ELOVL6 ALG9

2.00e-04170303833b4f44ea1fa673dfc6b43ce45a79fe68ae3b05
ToppCellnormal_Pleural_Fluid-T/NK_cells-Cytotoxic_CD8+_T|normal_Pleural_Fluid / Location, Cell class and cell subclass

PTPN22 ERBB4 SYNE2

2.03e-041713036be81c20f4e962b414afcedfe478dd59c510d1e1
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1_VIP_PCDH20|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 GRIN2D LRRC3B

2.07e-0417230335e961c88bfe79046533396912cedf00ca81db7b
ToppCellBL-critical-LOC-Lymphoid-PC|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)

PDIA5 RASSF6 ALG9

2.10e-0417330390700a876d997f7c0f7b3899dffcda7fdafee547
ToppCelldroplet-Marrow-nan-3m-Lymphocytic-NK_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

STK10 ABCA1 SYNE2

2.17e-04175303cf53a15bfb37b6019e7052ffdf594a9ac040900e
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5-6_PVALB_STON2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GPAT3 ERBB4 GRIN2D

2.21e-04176303682a1dfcc507ec540f5fadf08e872533ea9f0291
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_GGH|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 GRIN2D LRRC3B

2.21e-0417630323f930dac5247ea6d4124da33933d61ad6e089af
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2-Inh_L1-6_PVALB_SCUBE3_(Chandelier_1)|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 GRIN2C GRIN2D

2.21e-0417630395d5a4fdff1b9c715636684d22e06f8727ac0e7a
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 GRIN2D LRRC3B

2.25e-0417730384116796ca4c7007508c0f1a68a1135c7b922278
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L1-2_PVALB_TAC1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 ABCA1 GRIN2C

2.29e-041783031985271984e6747941c8d2097d9c58f0260f021a
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 GRIN2D LRRC3B

2.29e-041783033c973aac16988e88f5677d3d695dd772ccfd6570
ToppCelldroplet-Limb_Muscle-MUSCLE-30m|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

HERC6 ARL6IP1 SYNE2

2.29e-0417830301dafd19de04eff459253eaa9a35debf8f3deedf
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L2-6_VIP_VIP|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 GRIN2D LRRC3B

2.32e-0417930301302505816f272243659e20d751b61a198a2fc0
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 GRIN2C GRIN2D

2.32e-041793033b0f8781232e1d42b6f8913bc989a14b3f978e79
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-6_VIP_RGS16|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 GRIN2D LRRC3B

2.32e-041793035bf191bdc0c32bce83ab5c38f0616e209e420e55
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)-Exc_L2-4_RORB_GRIK1|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GPAT3 OR2AG2 PDIA5

2.36e-04180303fd8c2059fcb382ffbfe19e598e37a49e1d5637b5
ToppCellASK428-Immune-NK_cell|ASK428 / Donor, Lineage and Cell class of Lung cells from Dropseq

STK10 PTPN22 SYNE2

2.36e-04180303857d09446e3e6737e83d0f10bfda2ba282d5ba75
ToppCellPBMC_fresh-frozen-Mild-Moderate_progression_d12-25-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c03-GZMK|Mild-Moderate_progression_d12-25 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PTPN22 ABCA2 SYNE2

2.40e-0418130312ff56fa2949c8d53360cdf2cacfd326e65b54aa
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 GRIN2D LRRC3B

2.40e-04181303062f00736eed96e4f4327615d093558dd7d82b20
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 GRIN2D LRRC3B

2.44e-04182303420a8fd30543e37a66ba0786215d056d308660d0
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L5_PVALB_CNTNAP3P2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GPAT3 ERBB4 GRIN2D

2.48e-04183303121791ef84e7ce377ed6f5b7953af8865e04958e
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 GRIN2D LRRC3B

2.52e-0418430332473dbdb2de66391157c5814ef34e790806e4f2
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_1-GABA_L1_LAMP5-Inh_L5-6_LAMP5_SFTA3_(Lamp5_Lhx6_2)|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 GRIN2D LRRC3B

2.52e-04184303e2de27cee3ea80f9b7a9a7884ceceeaa67b3214a
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GPAT3 ERBB4 GRIN2D

2.52e-041843032ba98708dfd7f1b2a661578a334684094ff453ad
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2-Inh_L1-3_VIP_ZNF322P1|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 GRIN2D LRRC3B

2.56e-041853030b5a0df58ae2ad8261f40f152775747af4f3937a
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_2|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 GRIN2D LRRC3B

2.56e-04185303bdfa8c284bbc5e85c806327fbb7778cf16242a38
ToppCellCOVID-19_Moderate-NK_activated|World / disease group, cell group and cell class

ELOVL6 HERC6 SYNE2

2.60e-04186303ff8f32f69516bf785224fa12f8139a95359b0279
ToppCell10x_3'_v3-thymus_(10x_3'_v3)-lymphocytic-innate_lymphocytic-mature_NK_T_cell|thymus_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

LIFR ABCA2 ELOVL6

2.60e-04186303c984e5729958237b101df96d1c89a236faacded6
ToppCellCOVID-19-Heart-EC_2|Heart / Disease (COVID-19 only), tissue and cell type

LRRC3B TMEM87B SYNE2

2.64e-0418730340ffc06a3e3251d9b12da390210d3e045af7537a
ToppCellControl-T_cells|Control / group, cell type (main and fine annotations)

STK10 PTPN22 SYNE2

2.64e-04187303f4e8e0eba58da89b56587667555a5d4754e108c7
ToppCelldroplet-Kidney-KIDNEY-1m-Endothelial-Pecam____kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIFR PDIA5 LRRC3B

2.68e-0418830351c6796a9488c056a10d048082015342c2e037f9
ToppCelldroplet-Kidney-KIDNEY-1m-Endothelial-kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIFR PDIA5 LRRC3B

2.68e-04188303b651024d58ed1bcfe0d80b21755f8bf709eda81f
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 GRIN2D LRRC3B

2.68e-041883036ee3f8f94ea7bdf652c9575fc65bff08070093a4
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 GRIN2D LRRC3B

2.68e-04188303c66fccdfe68760b8c3efca77e3c25966dc9a8a5f
ToppCell(0)_NK_CD160pos|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)

PTPN22 ABCA2 ELOVL6

2.72e-04189303713991025bb92d38cb0507ff01fd91b48c8af45a
ToppCellCOVID-19-T_cells-CD8+_T_cells|COVID-19 / group, cell type (main and fine annotations)

STK10 PTPN22 SYNE2

2.72e-041893032c018d6120f65f0b2704b483bc9da1c0984872e3
ToppCellCOVID-19-T_cells-NK_cells|COVID-19 / group, cell type (main and fine annotations)

STK10 PTPN22 SYNE2

2.72e-04189303b699152dfbb8cd8ed724e1e5a51838f29b681b62
ToppCellControl-T_cells-CD4+_T_cells|Control / group, cell type (main and fine annotations)

STK10 PTPN22 SYNE2

2.77e-041903030733be5e54fe15d6d6ea51c154a95258e83f1b92
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_PVALB_1-Inh_L2-4_PVALB_C8orf4|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

GPAT3 ERBB4 GRIN2D

2.77e-041903030acf1d5da68db449d8c9e70519a236ce825f9d11
ToppCellIPF-Lymphoid-T|IPF / Disease state, Lineage and Cell class

PTPN22 ELOVL6 SYNE2

2.77e-04190303d57df208aaf7a5554899bb9107c80b443fd0cf93
ToppCellILEUM-non-inflamed|ILEUM / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

LIFR PTPN22 ELOVL6

2.81e-04191303c4a78ef7b87ffadbb1b9b69cbfa7c164ca456f9a
ToppCellCOVID-19-Myeloid-DC1|Myeloid / Condition, Lineage and Cell class

GPAT3 PTPN22 GPR33

2.81e-041913034be3c6287965fe3a2f109d26f68bdc2fa393f99b
ToppCellCOVID-19-T_cells|COVID-19 / group, cell type (main and fine annotations)

STK10 PTPN22 SYNE2

2.81e-041913037f64add931b64b8d35836fa6bee9ebab593844d3
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_2|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ERBB4 GRIN2D LRRC3B

2.85e-041923036a252e298f8a454623fa9c1c893a7a45a886d694
ToppCellControl-Lymphoid-T|World / Disease state, Lineage and Cell class

PTPN22 ELOVL6 SYNE2

2.85e-04192303253cf4d2cf88ad8c45b73779336180840bef054b
ToppCellfacs-Thymus-Epithelium-24m-Endothelial|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIFR PDIA5 LRRC3B

2.85e-0419230339afea574725ce0c67afdd79facdb34f819a828d
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_T-CytoT_GZMH+-male|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

PTPN22 ARL6IP1 SYNE2

2.85e-04192303fdc741e1846cfd8ed741b160e3c611c310c5d36d
ToppCellCOPD-Lymphoid-T|World / Disease state, Lineage and Cell class

PTPN22 ELOVL6 SYNE2

2.85e-04192303eb4909574fb5fc91399463523e2737095773200a
ToppCellfacs-Thymus-Epithelium-24m-Endothelial-endothelial_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIFR PDIA5 LRRC3B

2.85e-04192303597db951b1fbc37db22134c3d27d3ec4ceaa85f7
ToppCellIPF-Lymphoid-T|World / Disease state, Lineage and Cell class

PTPN22 ELOVL6 SYNE2

2.85e-04192303b25ba1f3bc842c22602b2aeed3b1b5082863e4fa
ToppCellfacs-Thymus-Epithelium-24m-Endothelial-endothelial_cell|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIFR PDIA5 LRRC3B

2.85e-04192303bc275a9eccb1c7a46fd58b15ca5acdd9f7495842
ToppCell3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GPAT3 ELOVL6 LRRC3B

2.90e-041933037cd9671e0ac64f7f3607f564485c63abbb7e7a63
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

PTPN22 HERC6 SYNE2

2.90e-041933036e1498153a7766c03fddbda1701dbf1596d21736
ToppCellControl-Lymphoid-T|Control / Disease state, Lineage and Cell class

PTPN22 ELOVL6 SYNE2

2.90e-04193303af928046ccd1ca874be1534aef6ca7f27d90bc46
ToppCellChildren_(3_yrs)-Immune-T_lymphocyte|Children_(3_yrs) / Lineage, Cell type, age group and donor

STK10 PTPN22 SYNE2

2.90e-04193303b9769b45125d2244afe53f9f71c92c04ddccf980
ToppCellsystemic_lupus_erythematosus-treated-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-female|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

PTPN22 HERC6 SYNE2

2.90e-04193303fce4f805e53669acb4c188f87ac7d84408c0c218
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

LIFR GUCY1B2 SYNE2

2.94e-041943038ddcaaf24cee6e30d5be52c0cbf778cfba309c53
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c05-ZNF683|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

PTPN22 ELOVL6 SYNE2

2.94e-0419430324837a27b0041fe8c348225fa8b09b127d743603
ToppCellCOVID-19-lung-NK_cells|COVID-19 / Disease (COVID-19 only), tissue and cell type

STK10 PTPN22 SYNE2

2.94e-041943034c92f18e0a34fb50630d4b260eaf179202508b6d
ToppCellcontrol-Lymphocytic-CD8_T_cells|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs

PTPN22 ARL6IP1 SYNE2

2.99e-0419530355b9052336cab3e769a126ecaeef267d8e7bcaa8
ToppCellfacs-Aorta-Heart-3m-Endothelial-aorta_endothelial_cell|Aorta / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LIFR PDIA5 LRRC3B

2.99e-041953033969b8d5fcec8ef1831531a781f7bbcebab5a4ba
ToppCellCOVID-19-lung-NK_cells|lung / Disease (COVID-19 only), tissue and cell type

STK10 PTPN22 SYNE2

2.99e-041953033b716ec7acc9a37af6bf40e711a539ce58d74aa4
ToppCellsystemic_lupus_erythematosus-flare-Lymphocytic_T-CytoT_GZMH+|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex

PTPN22 ARL6IP1 SYNE2

2.99e-041953031a7c2c4cf30df435770794a989be438579bf98f2
ToppCellCOPD-Lymphoid-T|COPD / Disease state, Lineage and Cell class

PTPN22 ELOVL6 SYNE2

3.03e-0419630330e53b8050d2a041f855d0e39bbd8f923c64c489
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_3_(KCNN3+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GPAT3 ELOVL6 LRRC3B

3.03e-04196303308fa54385ca34e9e590967d4553b84aad96c92f
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_ILC-NK_cell|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

STK10 ABCA2 SYNE2

3.03e-0419630308714b70ddaee7d11397c1dd4a287d412edd90f7
ToppCell10x_3'_v2v3-Non-neoplastic-Lymphoid-CD4/CD8-Stress_sig-Z|10x_3'_v2v3 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

STK10 PTPN22 SYNE2

3.03e-04196303578afe58962a24874b99b0407a647b12e972344b
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c06-TNF|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PTPN22 ABCA2 SYNE2

3.03e-04196303bc4628d959d76c16981ac3b943f7c3fbbba49391
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_ILC|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

STK10 ABCA2 SYNE2

3.03e-041963035bcc959db7deb34d5a32d3464367d47d4945cdaf
ToppCell10x5'-blood-Lymphocytic_T_CD8|blood / Manually curated celltypes from each tissue

PTPN22 ARL6IP1 SYNE2

3.03e-041963032bf0f36af1d0934c03999dbbff3c51ae9432386d
ToppCellPBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_ILC-NK_cell-NK_c01-FCGR3A|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)

STK10 ABCA2 SYNE2

3.08e-04197303f84263c5aaf3a5cd46d6e06358e8de6c6e6eaa3b
ToppCellFetal_brain-fetalBrain_Zhong_nature-GW08-Neuronal-GABAergic_neurons|GW08 / Sample Type, Dataset, Time_group, and Cell type.

ERBB4 GRIN2A RASSF6

3.08e-04197303e1a80c1aa7f7e83f5d19a40fe37db5c5a6c25685
ToppCellCOVID_non-vent-Lymphocytic-T_cell-CD8+_Memory_T_cell|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

STK10 ABCA2 SYNE2

3.08e-04197303836061acd7f0d5de89b16f52ec679bdf09eac9db
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-6_mon-Macroglial|6_mon / Sample Type, Dataset, Time_group, and Cell type.

LIFR GRIN2A LRRC3B

3.08e-04197303965d5a3f8c9b12cb8a8d3429702ae29ebd8c6122
ToppCellSevere-Lymphoid-T-CD8_T|Severe / Condition, Lineage, Cell class and cell subclass

PTPN22 ABCA2 SYNE2

3.08e-0419730300d884ec591f63a345d7fd0a6b368f9da4b4c6ce
ToppCellPBMC_fresh-frozen-Mild-Moderate_convalescent_d36-51-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell|Mild-Moderate_convalescent_d36-51 / Compartment, severity and other cell annotations on 10x 3' data (130k)

PTPN22 ABCA2 SYNE2

3.08e-04197303a44501cac24c2f4a53b413e92bd060eed6514616
ToppCellBrain_organoid-organoid_Paulsen_bioRxiv-6_mon-Macroglial-Astroglia|6_mon / Sample Type, Dataset, Time_group, and Cell type.

LIFR GRIN2A LRRC3B

3.08e-041973033f088eb29197bc575400d6dafd8083e69e4a149f
ToppCell10x3'2.3-week_17-19-Myeloid_neutrophil-granulo-neutrophil|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

GPAT3 PTPN22 SYNE2

3.12e-0419830382f6ac18c3a6487f03579b5c247844f1c115c2be
ToppCellNon-neuronal-Dividing-Radial_Glia-vRG-20|World / Primary Cells by Cluster

LIFR LRRC3B SYNE2

3.12e-04198303bce0bc1e3f2257e0f42a1fa6e5b57cf71e4514ba
ToppCell10x3'2.3-week_17-19-Myeloid_neutrophil-granulo|week_17-19 / cell types per 3 fetal stages;per 3',per 5'

GPAT3 PTPN22 SYNE2

3.12e-04198303f870e398e996c1f28c8462d87b18f71b20c71011
ToppCellTracheal-NucSeq-Immune_Lymphocytic-NK-ILC-T_NK-NK|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

STK10 PTPN22 ARL6IP1

3.17e-04199303598937913fe1f12d741fa49e23ae195a7be5cbe3
ToppCellmLN-(0)_NK_cell-(00)_NK|mLN / shred on region, Cell_type, and subtype

PTPN22 ABCA2 ELOVL6

3.17e-0419930359d8e4f57580c7273308c32e5308fc1d704b1f6d
ToppCellmLN-NK_cell-NK|mLN / Region, Cell class and subclass

PTPN22 ABCA2 ELOVL6

3.17e-04199303cc9836b8d18edabe8849a3e948b84d954ef68c48
ToppCellmLN-(0)_NK_cell|mLN / shred on region, Cell_type, and subtype

PTPN22 ABCA2 ELOVL6

3.17e-0419930305f5ae4c049f242131a7f59bcce4b18ed52f11be
ToppCellCOVID_non-vent-Lymphocytic-ILC|COVID_non-vent / Disease condition, Lineage, Cell class and subclass

STK10 ABCA2 SYNE2

3.17e-04199303df4f7d5be099e3e6054f3b812ccf70251664e4c0
Drug5-(alpha-methyl-4-bromobenzylamino)phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione

GRIN2A GRIN2C GRIN2D

2.28e-085313ctd:C498554
Drug(2S*,3R*)-1-(biphenyl-4-carbonyl)piperazine-2,3-dicarboxylic acid

GRIN2A GRIN2C GRIN2D

2.28e-085313ctd:C491996
Drug2-Aminoadipic Acid

GRIN2A GRIN2C GRIN2D

2.28e-085313ctd:D015074
DrugSDZ EAA 494

GRIN2A GRIN2C GRIN2D

2.28e-085313ctd:C065286
DrugNaphthols

GRIN2A GRIN2C GRIN2D

4.56e-086313ctd:D009284
DrugMeperidine

GRIN2A GRIN2C GRIN2D

4.56e-086313DB00454
Drug1,5-(diethylamino)piperidine

GRIN2A GRIN2C GRIN2D

4.56e-086313CID000004025
Drug3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid

GRIN2A GRIN2C GRIN2D

7.97e-087313ctd:C050592
DrugTenocyclidine

GRIN2A GRIN2C GRIN2D

7.97e-087313DB01520
Drugtetrazol-5-yl)glycine

GRIN2A GRIN2C GRIN2D

7.97e-087313CID000126383
Drughomoquinolinate

GRIN2A GRIN2C GRIN2D

7.97e-087313CID003080554
DrugS)-piperazine-2-carboxylic acid

GRIN2A GRIN2C GRIN2D

7.97e-087313CID001502069
Drug6-chloroquinoxaline-2,3-diol

GRIN2A GRIN2C GRIN2D

1.27e-078313CID000081143
DrugES-242-1

GRIN2A GRIN2C GRIN2D

1.27e-078313CID000131976
Drugpiperazine-2,3-dicarboxylic acid

GRIN2A GRIN2C GRIN2D

1.27e-078313CID000280973
DrugSDZ 220-581

GRIN2A GRIN2C GRIN2D

1.27e-078313CID000128019
Drug3alpha5betaHS

GRIN2A GRIN2C GRIN2D

1.27e-078313CID000165024
Drugneramexane

GRIN2A GRIN2C GRIN2D

1.27e-078313CID006433106
DrugL-687,414

GRIN2A GRIN2C GRIN2D

1.27e-078313CID000125556
DrugPhenanthrenes

GRIN2A GRIN2C GRIN2D

1.91e-079313ctd:D010616
Drug5-phosphonopentanoic acid

GRIN2A GRIN2C GRIN2D

3.74e-0711313CID002773807
DrugEAB 515

GRIN2A GRIN2C GRIN2D

3.74e-0711313CID000159489
Drugo-difluorobenzene

GRIN2A GRIN2C GRIN2D

3.74e-0711313CID000009706
Drugoxiracetam

GRIN2A GRIN2C GRIN2D

3.74e-0711313CID000004626
DrugCI-1041

GRIN2A GRIN2C GRIN2D

4.99e-0712313CID000156328
Drugtenocyclidine

GRIN2A GRIN2C GRIN2D

4.99e-0712313CID000062751
DrugAgmatine

GRIN2A GRIN2C GRIN2D

6.48e-0713313ctd:D000376
Drug1,10-diaminodecane

GRIN2A GRIN2C GRIN2D

6.48e-0713313CID000001317
Drug1c88

PTPN22 GRIN2A GRIN2C GRIN2D KIR2DS3

7.26e-07126315CID000444766
Drugremacemide

GRIN2A GRIN2C GRIN2D

8.23e-0714313CID000060510
Drugthiokynurenic acid

GRIN2A GRIN2C GRIN2D

1.03e-0615313CID003035667
DrugACEA-1011

GRIN2A GRIN2C GRIN2D

1.03e-0615313CID000127872
Drugargiopine

GRIN2A GRIN2C GRIN2D

1.26e-0616313CID000122294
Drug3,4,7,8-tetrahydroquinoline

GRIN2A GRIN2C GRIN2D

1.26e-0616313CID000094356
DrugLY233536

GRIN2A GRIN2C GRIN2D

1.26e-0616313CID000126239
Drugmetaphit

GRIN2A GRIN2C GRIN2D

1.26e-0616313CID000114745
Drug7-Cl-Thio-Kyna

GRIN2A GRIN2C GRIN2D

1.53e-0617313CID003035668
DrugPRE-084

GRIN2A GRIN2C GRIN2D

1.53e-0617313CID000126402
DrugADCI

GRIN2A GRIN2C GRIN2D

1.53e-0617313CID000130099
Drug3-hydroxyglutaric acid

GRIN2A GRIN2C GRIN2D

1.84e-0618313CID000181976
DrugMNQX

GRIN2A GRIN2C GRIN2D

1.84e-0618313CID000130818
Drugarcaine

GRIN2A GRIN2C GRIN2D

2.18e-0619313CID000002227
DrugC22H28N2O4

GRIN2A GRIN2C GRIN2D

2.18e-0619313CID000065570
DrugIDRA 21

GRIN2A GRIN2C GRIN2D

2.56e-0620313CID000003688
Drugcarbetapentane

GRIN2A GRIN2C GRIN2D

2.99e-0621313CID000002562
DrugNS 102

GRIN2A GRIN2C GRIN2D

3.46e-0622313CID005282252
DrugCX516

GRIN2A GRIN2C GRIN2D

3.46e-0622313CID000148184
DrugD-G-G

GRIN2A GRIN2C GRIN2D

3.97e-0623313CID000444866
DrugYM90K

GRIN2A GRIN2C GRIN2D

3.97e-0623313CID005486547
Drugpentanol

GRIN2A GRIN2C GRIN2D

3.97e-0623313CID000006276
DrugCGP 39653

GRIN2A GRIN2C GRIN2D

4.54e-0624313CID006437837
DrugRS)-2-chloro-5-hydroxyphenylglycine

GRIN2A GRIN2C GRIN2D

4.54e-0624313CID003645780
Druggavestinel

GRIN2A GRIN2C GRIN2D

5.15e-0625313CID006450546
Drugbudipine

GRIN2A GRIN2C GRIN2D

5.15e-0625313CID000068778
Drugconotoxin GV

GRIN2A GRIN2C

5.38e-063312ctd:C055407
DrugAC1NQH9B

GRIN2A GRIN2C GRIN2D

5.82e-0626313CID005221504
DrugAC1L1BL0

GRIN2A GRIN2C GRIN2D

5.82e-0626313CID000001484
Drug2-chloropropionate

GRIN2A GRIN2C GRIN2D

6.54e-0627313CID000011734
DrugSKF 10,047

GRIN2A GRIN2C GRIN2D

6.54e-0627313CID000001235
DrugL-689,560

GRIN2A GRIN2C GRIN2D

6.54e-0627313CID000121918
Drugaurintricarboxylic acid

ERBB4 GRIN2A GRIN2C GRIN2D

6.92e-0691314CID000002259
Drugchlormethiazole

GRIN2A GRIN2C GRIN2D

7.32e-0628313CID000010783
Drugaptiganel

GRIN2A GRIN2C GRIN2D

7.32e-0628313CID000060839
DrugC-PP

GRIN2A GRIN2C GRIN2D

7.32e-0628313CID000001228
DrugDL-Serine

STK10 ABCA2 GRIN2A GRIN2C GRIN2D

7.55e-06203315CID000000617
DrugAC1NUW3V

GRIN2A GRIN2C GRIN2D

8.15e-0629313CID005462126
Drugketobemidone

GRIN2A GRIN2C GRIN2D

8.15e-0629313CID000010101
DrugLY293558

GRIN2A GRIN2C GRIN2D

9.05e-0630313CID000127894
DrugAC1L32TU

GRIN2A GRIN2C GRIN2D

9.05e-0630313CID000107831
Drugcis-2,3-piperidine dicarboxylic acid

GRIN2A GRIN2C GRIN2D

9.05e-0630313CID000001226
DrugGYKI 53655

GRIN2A GRIN2C GRIN2D

9.05e-0630313CID000126757
DrugLY235959

GRIN2A GRIN2C GRIN2D

1.00e-0531313CID000131938
Drug4-methylglutamic acid

GRIN2A GRIN2C GRIN2D

1.00e-0531313CID000005365
Drugeliprodil

GRIN2A GRIN2C GRIN2D

1.00e-0531313CID000060703
DrugNPC 12626

GRIN2A GRIN2C GRIN2D

1.00e-0531313CID000108099
DrugPoly C

GRIN2A GRIN2C

1.07e-054312ctd:D011066
Drugindole-2-carboxylic acid

GRIN2A GRIN2C GRIN2D

1.10e-0532313CID000072899
Drugremifentanil

GRIN2A GRIN2C GRIN2D

1.10e-0532313CID000060814
DrugNSC-673323

GRIN2A GRIN2C GRIN2D

1.10e-0532313CID000384101
Drugalpha-methyl-4-carboxyphenylglycine

GRIN2A GRIN2C GRIN2D

1.10e-0532313CID000001222
Drugpentamidine

GRIN2A GRIN2C GRIN2D

1.21e-0533313CID000004735
Drug1-aminoindan-1,5-dicarboxylic acid

GRIN2A GRIN2C GRIN2D

1.21e-0533313CID000002071
DrugBMY 14802

GRIN2A GRIN2C GRIN2D

1.21e-0533313CID000108046
Drug6,7-dinitroquinoxaline

GRIN2A GRIN2C GRIN2D

1.21e-0533313CID002724608
DrugD-CPPene

GRIN2A GRIN2C GRIN2D

1.33e-0534313CID006435801
Drugnorethisterone oenanthate

ABCA2 GRIN2A GRIN2C GRIN2D

1.42e-05109314CID000019688
Drugkainite

GRIN2A GRIN2C GRIN2D

1.45e-0535313CID000164810
Drug3-7a

GRIN2A GRIN2C GRIN2D

1.58e-0536313CID011987860
DrugPhTX-343

GRIN2A GRIN2C GRIN2D

1.58e-0536313CID000159548
Drug3-bromo-7-nitroindazole

GRIN2A GRIN2C GRIN2D

1.58e-0536313CID000001649
DrugC6H12NO5P

GRIN2A GRIN2C GRIN2D

1.58e-0536313CID000104962
Drugglutamic acid diethyl ester

GRIN2A GRIN2C GRIN2D

1.58e-0536313CID000073960
Druggacyclidine

GRIN2A GRIN2C GRIN2D

1.58e-0536313CID000176265
DrugR,S)-AMPA

GRIN2A GRIN2C GRIN2D

1.58e-0536313CID000001221
Druggamma-Glu-Gly

GRIN2A GRIN2C GRIN2D

1.72e-0537313CID000100099
Drugrilmenidine

GRIN2A GRIN2C GRIN2D

1.72e-0537313CID000068712
Drugbenzyloxyaspartate

GRIN2A GRIN2C GRIN2D

1.72e-0537313CID004133412
DrugGAMs

GRIN2A GRIN2C GRIN2D

1.87e-0538313CID000002935
DrugL-BMAA

GRIN2A GRIN2C GRIN2D

1.87e-0538313CID000028558
DrugCGS 19755

GRIN2A GRIN2C GRIN2D

1.87e-0538313CID000068736
Diseasedevelopmental disorder of mental health (implicated_via_orthology)

GRIN2A GRIN2C GRIN2D

1.37e-0549283DOID:0060037 (implicated_via_orthology)
DiseaseSchizophrenia

LIFR ERBB4 ABCA1 GRIN2A GRIN2C GRIN2D EML5

1.43e-05883287C0036341
Diseasearabinose measurement

ERBB4 ABCA1

1.82e-057282EFO_0021030
DiseaseHDL cholesterol change measurement

ABCA1 SYNE2

2.37e-0424282EFO_0007805
Diseasesystemic mastocytosis

ABCA1 ABCA2

2.57e-0425282MONDO_0016586
Diseaseepilepsy (implicated_via_orthology)

GRIN2A GRIN2C GRIN2D

4.90e-04163283DOID:1826 (implicated_via_orthology)
Diseasesystemic scleroderma, rheumatoid arthritis, myositis, systemic lupus erythematosus

PTPN22 PHTF1

5.98e-0438282EFO_0000685, EFO_0000717, EFO_0000783, MONDO_0007915
Diseasemyositis

PTPN22 PHTF1

6.30e-0439282EFO_0000783
Diseasetriglycerides in large LDL measurement

ABCA1 SYNE2

7.65e-0443282EFO_0022319
Diseasemonokine induced by gamma interferon measurement

TMEM87B PHTF1

1.12e-0352282EFO_0008236
Diseasetriglycerides in LDL measurement

ABCA1 SYNE2

1.30e-0356282EFO_0022320
Diseaserheumatoid arthritis, ACPA-positive rheumatoid arthritis, rheumatoid factor seropositivity measurement

PTPN22 PHTF1

1.64e-0363282EFO_0000685, EFO_0007791, EFO_0009459
DiseaseColorectal Neoplasms

ABCA1 GRIN2A LRRC3B

2.25e-03277283C0009404

Protein segments in the cluster

PeptideGeneStartEntry
TIDVYMVMVKCWMID

ERBB4

946

Q15303
CMYTTLIAMTGWYMD

ALG9

196

Q9H6U8
VMMTAIISFFVCWMP

GPR33

246

Q49SQ1
MSRSMPLFMTLAWIY

ABCA1

636

O95477
MYFMTMIVSLAAVAW

ARL6IP1

136

Q15041
EKMTMMAHQYPSWIF

RASSF6

31

Q6ZTQ3
MSVIMICMFLVAWSP

RRH

241

O14718
MIWEYSVLIIVMACM

PTPN22

116

Q9Y2R2
MWGAYSVLAMAPTMI

CDRT4

101

Q8N9R6
KYMTLMSPRVCWIMV

OR2AG2

131

A6NM03
FMYPEMGSCMWFPAK

HERC6

736

Q8IVU3
MSLMVISMACVGFFW

KIR2DS3

1

Q14952
MLVTMFGWFTMVISY

LRRC3B

206

Q96PB8
VSHFMPVMFSLTWDM

TUFM

371

P49411
IMSKAAYMPMAASSW

OR2S2

136

Q9NQN1
MLMGCVVNYLVFCWM

ELOVL6

206

Q9H5J4
MMTSWAIVCDVWYMP

GPAT3

356

Q53EU6
GAAYAWMMCVFTVVM

TMEM63B

621

Q5T3F8
WMMCVFTVVMTYSIT

TMEM63B

626

Q5T3F8
FVIEHMMPLCMVISW

ABCA2

701

Q9BZC7
MMPLCMVISWVYSVA

ABCA2

706

Q9BZC7
MMCAVYGWTEEMAFS

EML5

866

Q05BV3
MMDIYVCLKRPSWMV

LIFR

1

P42702
MFYAPWCSMCKRMMP

PDIA5

176

Q14554
MMTIRFWYCMEHSKP

SYNE2

5291

Q8WXH0
IWMESMWCMVYLCSP

GUCY1B2

281

O75343
WEIKMTSPVYGTDMM

SPSB3

151

Q6PJ21
TWMFFFMMCVAERTY

PHTF1

541

Q9UMS5
PYWMAPEVVMCETMK

STK10

196

O94804
ASDWPLMIFYMVMCI

TMEM87B

211

Q96K49
EPFSASVWVMMFVML

GRIN2A

551

Q12879
YSPAVWVMMFVMCLT

GRIN2C

551

Q14957
YSPAVWVMMFVMCLT

GRIN2D

581

O15399