Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	histone deacetylase activity	MIER2 ATXN3L HDAC2	1.51e-04	24	87	3	GO:0004407
GeneOntologyMolecularFunction	protein lysine deacetylase activity	MIER2 ATXN3L HDAC2	1.71e-04	25	87	3	GO:0033558
Domain	RNA_pol_Rpb1_2	POLR2A POLR3A	5.70e-05	3	82	2	PF00623
Domain	RPOLA_N	POLR2A POLR3A	5.70e-05	3	82	2	SM00663
Domain	RNA_pol_Rpb1_4	POLR2A POLR3A	5.70e-05	3	82	2	IPR007083
Domain	RNA_pol_Rpb1_5	POLR2A POLR3A	5.70e-05	3	82	2	IPR007081
Domain	RNA_pol_Rpb1_1	POLR2A POLR3A	5.70e-05	3	82	2	IPR007080
Domain	RNA_pol_Rpb1_3	POLR2A POLR3A	5.70e-05	3	82	2	IPR007066
Domain	RNA_pol_asu	POLR2A POLR3A	5.70e-05	3	82	2	IPR000722
Domain	RNA_pol_N	POLR2A POLR3A	5.70e-05	3	82	2	IPR006592
Domain	RNA_pol_Rpb1_1	POLR2A POLR3A	5.70e-05	3	82	2	PF04997
Domain	RNA_pol_Rpb1_5	POLR2A POLR3A	5.70e-05	3	82	2	PF04998
Domain	RNA_pol_Rpb1_3	POLR2A POLR3A	5.70e-05	3	82	2	PF04983
Domain	RNA_pol_Rpb1_4	POLR2A POLR3A	5.70e-05	3	82	2	PF05000
Domain	DAG/PE-bd	RASGRP3 PRKCB PRKCI	1.02e-04	21	82	3	IPR020454
Domain	Cadherin_CS	DCHS2 FAT4 CDH23 PCDHA6	1.35e-03	109	82	4	IPR020894
Domain	CADHERIN_1	DCHS2 FAT4 CDH23 PCDHA6	1.55e-03	113	82	4	PS00232
Domain	Cadherin	DCHS2 FAT4 CDH23 PCDHA6	1.55e-03	113	82	4	PF00028
Domain	CADHERIN_2	DCHS2 FAT4 CDH23 PCDHA6	1.60e-03	114	82	4	PS50268
Domain	-	DCHS2 FAT4 CDH23 PCDHA6	1.60e-03	114	82	4	2.60.40.60
Domain	CA	DCHS2 FAT4 CDH23 PCDHA6	1.65e-03	115	82	4	SM00112
Domain	IMPORTIN_B_NT	TNPO1 XPO7	1.67e-03	14	82	2	PS50166
Domain	Cadherin-like	DCHS2 FAT4 CDH23 PCDHA6	1.70e-03	116	82	4	IPR015919
Domain	Cadherin	DCHS2 FAT4 CDH23 PCDHA6	1.81e-03	118	82	4	IPR002126
Domain	AGC-kinase_C	GRK5 PRKCB PRKCI	1.91e-03	56	82	3	IPR000961
Domain	AGC_KINASE_CTER	GRK5 PRKCB PRKCI	1.91e-03	56	82	3	PS51285
Domain	S_TK_X	GRK5 PRKCB PRKCI	1.91e-03	56	82	3	SM00133
Domain	IBN_N	TNPO1 XPO7	1.93e-03	15	82	2	PF03810
Domain	C1_1	RASGRP3 PRKCB PRKCI	2.01e-03	57	82	3	PF00130
Domain	IBN_N	TNPO1 XPO7	2.20e-03	16	82	2	SM00913
Domain	Importin-beta_N	TNPO1 XPO7	2.48e-03	17	82	2	IPR001494
Domain	UIM	ANKRD13B ATXN3L	2.78e-03	18	82	2	PF02809
Domain	ZF_DAG_PE_1	RASGRP3 PRKCB PRKCI	2.80e-03	64	82	3	PS00479
Domain	ZF_DAG_PE_2	RASGRP3 PRKCB PRKCI	2.80e-03	64	82	3	PS50081
Domain	C1	RASGRP3 PRKCB PRKCI	2.93e-03	65	82	3	SM00109
Domain	PE/DAG-bd	RASGRP3 PRKCB PRKCI	3.06e-03	66	82	3	IPR002219
Domain	UIM	ANKRD13B ATXN3L	3.79e-03	21	82	2	SM00726
Domain	UIM	ANKRD13B ATXN3L	4.94e-03	24	82	2	PS50330
Domain	UIM_dom	ANKRD13B ATXN3L	5.35e-03	25	82	2	IPR003903
Pubmed	Identifications of novel host cell factors that interact with the receptor-binding domain of the SARS-CoV-2 spike protein.	PLCD3 DOCK5 XRN2 ARNT RBBP5 AFDN UGGT2 PRKCI MICAL3 TASOR POLR3A	6.92e-07	650	87	11	38777146
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	CDK8 DOCK5 COL5A1 ARHGAP6 SPATA6 CARMIL1 SIPA1L3 RAB3IP INSR TPGS1 PRKCI MICAL3 PDE10A SNX9 BABAM2 XPO7	7.87e-07	1489	87	16	28611215
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PLCD3 TRAPPC12 GRK5 POLR2A SIPA1L3 NAGLU MICAL3 ITGA3 MLXIP MED13L BABAM2 ALOX5 CABLES1	3.63e-06	1105	87	13	35748872
Pubmed	An Oct4-centered protein interaction network in embryonic stem cells.	CDK8 SALL3 RBBP5 POLR2A MED13L HDAC2	4.10e-06	167	87	6	20362541
Pubmed	Requirement of atypical protein kinase clambda for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytes.	INSR PRKCI	6.19e-06	2	87	2	9819385
Pubmed	Temporal and spatial localization of nectin-1 and l-afadin during synaptogenesis in hippocampal neurons.	NECTIN1 AFDN	6.19e-06	2	87	2	18181141
Pubmed	RNA-binding protein CUGBP1 controls the differential INSR splicing in molecular subtypes of breast cancer cells and affects cell aggressiveness.	CELF1 INSR	6.19e-06	2	87	2	31958132
Pubmed	Identification of new human cadherin genes using a combination of protein motif search and gene finding methods.	DCHS2 FAT4	6.19e-06	2	87	2	15003449
Pubmed	Conditional Knock-out of mGluR5 from Astrocytes during Epilepsy Development Impairs High-Frequency Glutamate Uptake.	POLR2A GRM5	6.19e-06	2	87	2	30504280
Pubmed	Protein kinase C (PKC) betaII induces cell invasion through a Ras/Mek-, PKC iota/Rac 1-dependent signaling pathway.	PRKCB PRKCI	6.19e-06	2	87	2	15037605
Pubmed	Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation.	RASGRP3 PRKCB	6.19e-06	2	87	2	15545601
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	DOCK5 FAT4 ADAMTS9 RBBP5 POLR2A NAGLU PRKCB ALOX5 DSE CABLES1	1.56e-05	736	87	10	29676528
Pubmed	Protein kinase C betaII and PKCiota/lambda: collaborating partners in colon cancer promotion and progression.	PRKCB PRKCI	1.85e-05	3	87	2	19147581
Pubmed	STAT5 proteins are involved in down-regulation of iron regulatory protein 1 gene expression by nitric oxide.	MTF1 ACO1	1.85e-05	3	87	2	16886906
Pubmed	Nectin: an adhesion molecule involved in formation of synapses.	NECTIN1 AFDN	1.85e-05	3	87	2	11827984
Pubmed	Ectodomain shedding of nectin-1 regulates the maintenance of dendritic spine density.	NECTIN1 AFDN	1.85e-05	3	87	2	22118475
Pubmed	Increased steady-state levels of CUGBP1 in myotonic dystrophy 1 are due to PKC-mediated hyperphosphorylation.	CELF1 PRKCB	1.85e-05	3	87	2	17936705
Pubmed	Integration of DAG signaling systems mediated by PKC-dependent phosphorylation of RasGRP3.	RASGRP3 PRKCB	1.85e-05	3	87	2	12730099
Pubmed	Cyclin C/CDK8 is a novel CTD kinase associated with RNA polymerase II.	CDK8 POLR2A	1.85e-05	3	87	2	8700522
Pubmed	Disruption of the nectin-afadin complex recapitulates features of the human cleft lip/palate syndrome CLPED1.	NECTIN1 AFDN	1.85e-05	3	87	2	32554531
Pubmed	SRp20 and CUG-BP1 modulate insulin receptor exon 11 alternative splicing.	CELF1 INSR	1.85e-05	3	87	2	19047369
Pubmed	Human 5' --> 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites.	XRN2 POLR2A	1.85e-05	3	87	2	15565158
Pubmed	PKC-β/Alox5 axis activation promotes Bcr-Abl-independent TKI-resistance in chronic myeloid leukemia.	PRKCB ALOX5	1.85e-05	3	87	2	33561320
Pubmed	Afadin is a scaffold protein repressing insulin action via HDAC6 in adipose tissue.	INSR AFDN	1.85e-05	3	87	2	31264358
Pubmed	Interaction of nectin with afadin is necessary for its clustering at cell-cell contact sites but not for its cis dimerization or trans interaction.	NECTIN1 AFDN	1.85e-05	3	87	2	10617658
Pubmed	Defects in the medial entorhinal cortex and dentate gyrus in the mouse model of Sanfilippo syndrome type B.	NAGLU IDS	3.70e-05	4	87	2	22096577
Pubmed	Identification of curcumin-inhibited extracellular matrix receptors in non-small cell lung cancer A549 cells by RNA sequencing.	COL5A1 ITGA3	3.70e-05	4	87	2	28618934
Pubmed	Insulin stimulates movement of sorting nexin 9 between cellular compartments: a putative role mediating cell surface receptor expression and insulin action.	INSR SNX9	3.70e-05	4	87	2	12917015
Pubmed	mGluR5-PLCbeta4-PKCbeta2/PKCgamma pathways in hippocampal CA1 pyramidal neurons in pilocarpine model of status epilepticus in mGluR5+/+ mice.	PRKCB GRM5	3.70e-05	4	87	2	18774262
Pubmed	Insulin Receptor Associates with Promoters Genome-wide and Regulates Gene Expression.	POLR2A INSR	3.70e-05	4	87	2	30955890
Pubmed	Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities.	NECTIN1 AFDN	3.70e-05	4	87	2	10744716
Pubmed	Rap1 GTPase is required for mouse lens epithelial maintenance and morphogenesis.	NECTIN1 AFDN PRKCI	3.77e-05	26	87	3	26212757
Pubmed	Characterization of a Dchs1 mutant mouse reveals requirements for Dchs1-Fat4 signaling during mammalian development.	DCHS2 FAT4 PRKCI	3.77e-05	26	87	3	21303848
Pubmed	A new member of the third class in the protein kinase C family, PKC lambda, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells.	PRKCB PRKCI	6.16e-05	5	87	2	7513693
Pubmed	Nectin/PRR: an immunoglobulin-like cell adhesion molecule recruited to cadherin-based adherens junctions through interaction with Afadin, a PDZ domain-containing protein.	NECTIN1 AFDN	6.16e-05	5	87	2	10225955
Pubmed	Phosphorylation of the menin tumor suppressor protein on serine 543 and serine 583.	RBBP5 POLR2A	6.16e-05	5	87	2	17050672
Pubmed	Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein.	CDK8 POLR2A	6.16e-05	5	87	2	12145330
Pubmed	Gene-centric association signals for haemostasis and thrombosis traits identified with the HumanCVD BeadChip.	ZPR1 GRK5	6.16e-05	5	87	2	24178511
Pubmed	The histone deacetylase inhibitor trichostatin A mediates upregulation of 5-lipoxygenase promoter activity by recruitment of Sp1 to distinct GC-boxes.	ALOX5 HDAC2	6.16e-05	5	87	2	17894944
Pubmed	CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium.	CDK8 POLR2A	6.16e-05	5	87	2	36545778
Pubmed	DIDO as a Switchboard that Regulates Self-Renewal and Differentiation in Embryonic Stem Cells.	POLR2A PRKCI	6.16e-05	5	87	2	28330622
Pubmed	Retroviral cyclin enhances cyclin-dependent kinase-8 activity.	CDK8 POLR2A	6.16e-05	5	87	2	22379099
Pubmed	Differential HDAC1 and 2 Recruitment by Members of the MIER Family.	MIER2 HDAC2	6.16e-05	5	87	2	28046085
Pubmed	Histone-binding of DPF2 mediates its repressive role in myeloid differentiation.	XRN2 SF3B3 RBBP5 PRKCB SNX9 HDAC2	8.00e-05	283	87	6	28533407
Pubmed	Differential gene expression during terminal erythroid differentiation.	TMEM131L XPO7	9.22e-05	6	87	2	17764892
Pubmed	Nectin4/PRR4, a new afadin-associated member of the nectin family that trans-interacts with nectin1/PRR1 through V domain interaction.	NECTIN1 AFDN	9.22e-05	6	87	2	11544254
Pubmed	BRCA1 ubiquitinates RPB8 in response to DNA damage.	POLR2A POLR3A	9.22e-05	6	87	2	17283126
Pubmed	Three cyclin-dependent kinases preferentially phosphorylate different parts of the C-terminal domain of the large subunit of RNA polymerase II.	CDK8 POLR2A	9.22e-05	6	87	2	15009212
Pubmed	PKCdelta associates with and is involved in the phosphorylation of RasGRP3 in response to phorbol esters.	RASGRP3 PRKCB	9.22e-05	6	87	2	15213298
Pubmed	Genetic deletion of afadin causes hydrocephalus by destruction of adherens junctions in radial glial and ependymal cells in the midbrain.	NECTIN1 AFDN	9.22e-05	6	87	2	24236178
Pubmed	Angiotensin II signaling via protein kinase C phosphorylates Kelch-like 3, preventing WNK4 degradation.	KLHL3 PRKCB	9.22e-05	6	87	2	25313067
Pubmed	Three RNA polymerase II carboxyl-terminal domain kinases display distinct substrate preferences.	CDK8 POLR2A	9.22e-05	6	87	2	11278802
Pubmed	Characterization and significance of adhesion and junction-related proteins in mouse ovarian follicles.	NECTIN1 AFDN	9.22e-05	6	87	2	22321830
Pubmed	The cell adhesion gene PVRL3 is associated with congenital ocular defects.	NECTIN1 AFDN	9.22e-05	6	87	2	21769484
Pubmed	Fabp7 maps to a quantitative trait locus for a schizophrenia endophenotype.	OFCC1 CDH23	9.22e-05	6	87	2	18001149
Pubmed	Expression patterns of nectins and afadin during epithelial remodeling in the mouse embryo.	NECTIN1 AFDN	9.22e-05	6	87	2	15108322
Pubmed	Interaction of muscleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicing.	CELF1 INSR	9.22e-05	6	87	2	16946708
Pubmed	An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.	TNPO1 DOCK5 XRN2 SF3B3 CARMIL1 RAB3IP CDH23 AFDN UGGT2 PRKCI SNX9 HDAC2	1.10e-04	1321	87	12	27173435
Pubmed	Factors associated with the mammalian RNA polymerase II holoenzyme.	CDK8 POLR2A	1.29e-04	7	87	2	9443979
Pubmed	Junction plakoglobin regulates and destabilizes HIF2α to inhibit tumorigenesis of renal cell carcinoma.	ARNT HDAC2	1.29e-04	7	87	2	33591636
Pubmed	Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila.	DCHS2 FAT4	1.29e-04	7	87	2	16059920
Pubmed	The Protein-tyrosine-phosphatase SHP2 is phosphorylated on serine residues 576 and 591 by protein kinase C isoforms alpha, beta 1, beta 2, and eta.	INSR PRKCB	1.29e-04	7	87	2	11781100
Pubmed	Poly(ADP-ribose) polymerase 1 (PARP-1) binds to 8-oxoguanine-DNA glycosylase (OGG1).	XRN2 HDAC2	1.72e-04	8	87	2	22057269
Pubmed	Diverse alternative back-splicing and alternative splicing landscape of circular RNAs.	POLR2A MED13L	1.72e-04	8	87	2	27365365
Pubmed	The expression and stage-specific localization of protein kinase C isotypes during mouse preimplantation development.	PRKCB PRKCI	1.72e-04	8	87	2	10882525
Pubmed	SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination.	XRN2 POLR2A	1.72e-04	8	87	2	26700805
Pubmed	Protein kinase C phosphorylation of the metabotropic glutamate receptor mGluR5 on Serine 839 regulates Ca2+ oscillations.	PRKCB GRM5	1.72e-04	8	87	2	15894802
Pubmed	Implications of nectin-like molecule-2/IGSF4/RA175/SgIGSF/TSLC1/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells.	NECTIN1 AFDN	1.72e-04	8	87	2	12826663
Pubmed	Nectins localize Willin to cell-cell junctions.	NECTIN1 AFDN	1.72e-04	8	87	2	22512338
Pubmed	Cajal-Retzius cells instruct neuronal migration by coincidence signaling between secreted and contact-dependent guidance cues.	NECTIN1 AFDN	2.20e-04	9	87	2	23931996
Pubmed	p63-dependent and independent mechanisms of nectin-1 and nectin-4 regulation in the epidermis.	NECTIN1 AFDN	2.20e-04	9	87	2	25387952
Pubmed	Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse.	NECTIN1 AFDN	2.20e-04	9	87	2	12515806
Pubmed	Inhibition of protein kinase C by a synthetic peptide corresponding to cytoplasmic domain residues 828-848 of the human immunodeficiency virus type 1 envelope glycoprotein.	PRKCB PRKCI	2.20e-04	9	87	2	7850771
Pubmed	Human immunodeficiency virus-1 recombinant gp120 induces changes in protein kinase C isozymes--a preliminary report.	PRKCB PRKCI	2.20e-04	9	87	2	8206685
Pubmed	Regulation of HIV-1 gag protein subcellular targeting by protein kinase C.	PRKCB PRKCI	2.20e-04	9	87	2	7876252
Pubmed	A uniform procedure for the purification of CDK7/CycH/MAT1, CDK8/CycC and CDK9/CycT1.	CDK8 POLR2A	2.20e-04	9	87	2	15328539
Pubmed	Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex.	CDK8 HDAC2	2.20e-04	9	87	2	9150135
Pubmed	Phosphorylation of HIV-1 gag proteins by protein kinase C.	PRKCB PRKCI	2.20e-04	9	87	2	8473314
Pubmed	Identification of two novel RanGTP-binding proteins belonging to the importin beta superfamily.	TNPO1 XPO7	2.20e-04	9	87	2	11024021
Pubmed	Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex.	XRN2 POLR2A	2.20e-04	9	87	2	22767893
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	TNPO1 XRN2 SF3B3 RBBP5 POLR2A MED13L BABAM2 POLR3A HDAC2 XPO7	2.23e-04	1014	87	10	32416067
Pubmed	A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology.	CDK8 POLR2A MED13L	2.26e-04	47	87	3	15175163
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	TNPO1 XRN2 ARNT SF3B3 HDAC2	2.35e-04	220	87	5	35785414
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	TNPO1 COL5A1 XRN2 POLR2A AFDN SNX9 HDAC2 XPO7	2.35e-04	653	87	8	22586326
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	MIER2 PLCD3 ADAMTS9 RASGRP3 SIPA1L3 MICAL3 TASOR	2.42e-04	493	87	7	15368895
Pubmed	Contacts between the commissural axons and the floor plate cells are mediated by nectins.	NECTIN1 AFDN	2.75e-04	10	87	2	15328010
Pubmed	Wdr82 is a C-terminal domain-binding protein that recruits the Setd1A Histone H3-Lys4 methyltransferase complex to transcription start sites of transcribed human genes.	RBBP5 POLR2A	2.75e-04	10	87	2	17998332
Pubmed	The phorbol ester TPA strongly inhibits HIV-1-induced syncytia formation but enhances virus production: possible involvement of protein kinase C pathway.	PRKCB PRKCI	2.75e-04	10	87	2	1970444
Pubmed	Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes.	POLR2A HDAC2	2.75e-04	10	87	2	11238380
Pubmed	Roles of cell-adhesion molecules nectin 1 and nectin 3 in ciliary body development.	NECTIN1 AFDN	2.75e-04	10	87	2	15728677
Pubmed	HIF1A employs CDK8-mediator to stimulate RNAPII elongation in response to hypoxia.	CDK8 MED13L	2.75e-04	10	87	2	23746844
Pubmed	PICK-1: a scaffold protein that interacts with Nectins and JAMs at cell junctions.	NECTIN1 AFDN	2.75e-04	10	87	2	15811349
Pubmed	Human immunodeficiency virus induces phosphorylation of its cell surface receptor.	PRKCB PRKCI	2.75e-04	10	87	2	3259291
Pubmed	Effect of serine and tyrosine phosphorylation on retroviral proteinase substrates.	PRKCB PRKCI	2.75e-04	10	87	2	10491200
Pubmed	Inhibition of protein kinase C and anti-CD3-induced Ca2+ influx in Jurkat T cells by a synthetic peptide with sequence identity to HIV-1 gp41.	PRKCB PRKCI	2.75e-04	10	87	2	2139676
Pubmed	The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function.	XRN2 PUM2	2.75e-04	10	87	2	23125361
Pubmed	Ablation of the oncogenic transcription factor ERG by deubiquitinase inhibition in prostate cancer.	XRN2 SF3B3 POLR2A	3.06e-04	52	87	3	24591637
Pubmed	Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover.	CDK8 POLR2A	3.35e-04	11	87	2	15546612
Pubmed	The atypical homeodomain transcription factor Mohawk controls tendon morphogenesis.	COL5A1 TNMD	3.35e-04	11	87	2	20696843
Pubmed	Specific isoforms of protein kinase C are essential for prevention of folate-resistant neural tube defects by inositol.	PRKCB PRKCI	3.35e-04	11	87	2	14613966
Cytoband	13q32.1	OXGR1 UGGT2	4.19e-04	16	87	2	13q32.1
Cytoband	3p14.3	DNAH12 TASOR	1.49e-03	30	87	2	3p14.3
Cytoband	4q31.3	DCHS2 TMEM131L	1.59e-03	31	87	2	4q31.3
Cytoband	1p33	SPATA6 MTF1	2.03e-03	35	87	2	1p33
GeneFamily	Cadherin related	DCHS2 FAT4 CDH23	1.86e-05	17	56	3	24
Coexpression	CYCLIN_D1_UP.V1_DN	ARNT HLA-DRA PUM2 ITGA3 ALOX5 HDAC2	4.16e-05	190	87	6	M2652
Coexpression	GSE16450_CTRL_VS_IFNA_12H_STIM_IMMATURE_NEURON_CELL_LINE_UP	CARMIL1 PRKCB MLXIP MED13L BABAM2 POLR3A	5.09e-05	197	87	6	M7403
Coexpression	GSE2197_IMMUNOSUPPRESSIVE_DNA_VS_UNTREATEDIN_DC_DN	CDK8 ACO1 INSR TMEM131L ACOT4 DDX11	5.38e-05	199	87	6	M4390
Coexpression	GSE37532_TREG_VS_TCONV_PPARG_KO_CD4_TCELL_FROM_VISCERAL_ADIPOSE_TISSUE_DN	ARHGAP6 SPATA6 TMEM30A BTLA MED13L GRM5	5.53e-05	200	87	6	M8956
Coexpression	GSE19401_NAIVE_VS_IMMUNIZED_MOUSE_PLN_FOLLICULAR_DC_DN	MTF1 TRAPPC12 POLR2A TMEM131L DDX11 XPO7	5.53e-05	200	87	6	M7658
Coexpression	GSE40273_EOS_KO_VS_WT_TREG_DN	TMEM131L PRKCB BTLA ITGA3 TASOR CNN2	5.53e-05	200	87	6	M9130
Coexpression	GSE30971_CTRL_VS_LPS_STIM_MACROPHAGE_WBP7_HET_4H_UP	ATP1B4 ARNT SPATA6 RAB3IP PRKCB SNX9	5.53e-05	200	87	6	M8705
CoexpressionAtlas	Myeloid Cells, DC.4+.Sp, CD11b CD45 CD4 CD11c CD8a, Spleen, avg-1	DOCK5 ARHGAP6 LRRC25 RASGRP3 CARMIL1 NECTIN1 TMEM131L PRKCB AFDN MICAL3	3.32e-06	382	86	10	GSM538248_500
CoexpressionAtlas	Myeloid Cells, DC.4+.MLN, CD11b-FITC CD4-PE CD11c-Alexa750 CD8a-PacificBlue, Lymph Node, avg-3	DOCK5 ARHGAP6 LRRC25 RASGRP3 CARMIL1 NECTIN1 TMEM131L PRKCB AFDN MICAL3	4.98e-06	400	86	10	GSM538242_500
CoexpressionAtlas	Myeloid Cells, DC.8-4-11b+.Sp, CD11b CD11c CD45 CD8a CD4, Spleen, avg-2	DOCK5 ARHGAP6 LRRC25 RASGRP3 CARMIL1 NECTIN1 TMEM131L MICAL3 BTLA	2.15e-05	376	86	9	GSM538266_500
CoexpressionAtlas	Myeloid Cells, DC.8-4-11b+.Sp, CD11b CD4 CD45 CD11c CD8a, Spleen, avg-1	DOCK5 ARHGAP6 LRRC25 RASGRP3 CARMIL1 NECTIN1 TMEM131L MICAL3 BTLA	3.17e-05	395	86	9	GSM538265_500
ToppCell	RV-01._Fibroblast_I\|World / Chamber and Cluster_Paper	COL5A1 ARHGAP6 SPATA6 CARMIL1 GRK5 UGGT2 PDE10A	9.76e-08	191	87	7	70c067c54084bfb02c29bab085f4defd477194fb
ToppCell	RV-01._Fibroblast_I\|RV / Chamber and Cluster_Paper	COL5A1 ARHGAP6 SPATA6 CARMIL1 GRK5 UGGT2 PDE10A	1.01e-07	192	87	7	356160b113c3305a61ceeaff33ce3c9da0be2878
ToppCell	Control-Myeloid-ncMonocyte\|Myeloid / Disease state, Lineage and Cell class	DOCK5 LRRC25 GRK5 INSR PRKCB MED13L SNX9	1.05e-07	193	87	7	3479c01aaae7afd7e02d00e0cb21951c0106a0fd
ToppCell	RV-02._Fibroblast_II\|RV / Chamber and Cluster_Paper	COL5A1 ARHGAP6 SPATA6 CARMIL1 GRK5 UGGT2 PDE10A	1.09e-07	194	87	7	11c79a8c56ece42713b04b321982e41e239f07a5
ToppCell	RV-02._Fibroblast_II\|World / Chamber and Cluster_Paper	COL5A1 ARHGAP6 SPATA6 CARMIL1 GRK5 UGGT2 PDE10A	1.12e-07	195	87	7	ce90b30dcdb56d4cd925cdb79fd9d7cefd998f48
ToppCell	Control-Myeloid-ncMonocyte\|World / Disease state, Lineage and Cell class	DOCK5 LRRC25 INSR CDH23 PRKCB MED13L SNX9	1.12e-07	195	87	7	b4444b67a709e82b8e2ee510924c3152cb88b051
ToppCell	COVID-19-kidney-Bcells\|kidney / Disease (COVID-19 only), tissue and cell type	HLA-DRA GRK5 TMEM131L PRKCB BTLA ALOX5	1.46e-06	180	87	6	5650fc7ebcdf5e0be9a217a58d36a8386d59fd1b
ToppCell	Fetal_29-31_weeks-Immune-B_cell-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	HLA-DRA SIPA1L3 TMEM131L PRKCB BTLA ALOX5	1.65e-06	184	87	6	f4c9272d5cc4a70df051413b5c60ca6d1d80eb84
ToppCell	COPD-Lymphoid-B\|COPD / Disease state, Lineage and Cell class	GRK5 SIPA1L3 PRKCB MICAL3 BTLA SNX9	1.71e-06	185	87	6	925e79c35c381dd44ec5fb921dca09ce43140135
ToppCell	lymphoid-B_cell-Naive_B_cell\|World / Lineage, cell class and subclass	HLA-DRA RASGRP3 PRKCB MICAL3 SNX9 ALOX5	1.82e-06	187	87	6	904ffd8cf4513e86fcd4c2b7faf24a34fbd2dce3
ToppCell	IPF-Lymphoid-B\|Lymphoid / Disease state, Lineage and Cell class	HLA-DRA RASGRP3 CARMIL1 SIPA1L3 PRKCB MICAL3	1.82e-06	187	87	6	af1327559f7e01bec070881cae52834917c3da65
ToppCell	lymphoid-B_cell\|World / Lineage, cell class and subclass	HLA-DRA RASGRP3 PRKCB MICAL3 SNX9 ALOX5	1.82e-06	187	87	6	2abbc01fd7f5b4e52113699625287893c991f8da
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_lymph_vessel-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	DOCK5 ADAMTS9 RASGRP3 OXGR1 MICAL3 THSD1	1.87e-06	188	87	6	aeecbc057dc823f8fcea8a98f18d213bacc7f4db
ToppCell	IPF-Myeloid-ncMonocyte\|Myeloid / Disease state, Lineage and Cell class	DOCK5 LRRC25 GRK5 INSR PRKCB SNX9	1.93e-06	189	87	6	5c22d2d935f7bb270260b8bc6be67b565ec401bf
ToppCell	COPD-Myeloid-ncMonocyte\|Myeloid / Disease state, Lineage and Cell class	DOCK5 LRRC25 GRK5 INSR PRKCB SNX9	1.99e-06	190	87	6	ed978cd5d9da87b49878a330e362762c487f849f
ToppCell	lymphoid-B_cell-Naive_B_cell\|lymphoid / Lineage, cell class and subclass	HLA-DRA RASGRP3 PRKCB MICAL3 SNX9 ALOX5	1.99e-06	190	87	6	b8b05894e811e431d797ac4fa3ccff4963a154e7
ToppCell	lymphoid-B_cell\|lymphoid / Lineage, cell class and subclass	HLA-DRA RASGRP3 PRKCB MICAL3 SNX9 ALOX5	1.99e-06	190	87	6	c451de643ee08c2ff1093e807c65d724237473c5
ToppCell	LV-01._Fibroblast_I\|World / Chamber and Cluster_Paper	COL5A1 ARHGAP6 SPATA6 CARMIL1 GRK5 UGGT2	1.99e-06	190	87	6	12992ec80a7b4f4f17de693f0719ee061a9918fd
ToppCell	COPD-Lymphoid-B\|Lymphoid / Disease state, Lineage and Cell class	HLA-DRA RASGRP3 CARMIL1 SIPA1L3 MICAL3 SNX9	1.99e-06	190	87	6	1e85ee686ff6dd27c69415d524d54fa825b1daad
ToppCell	Fetal_29-31_weeks-Immune-B_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	HLA-DRA SIPA1L3 TMEM131L PRKCB BTLA ALOX5	2.05e-06	191	87	6	84452125d1b5b76974e3f9126f611eff16d45c25
ToppCell	IPF-Myeloid-ncMonocyte\|IPF / Disease state, Lineage and Cell class	DOCK5 LRRC25 INSR CDH23 PRKCB SNX9	2.12e-06	192	87	6	e9fb8c57d8094f70fb492909b2bec40aa5f2e5b8
ToppCell	Fetal_29-31_weeks-Endothelial-capillary_endothelial_cell_(Cap1)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	SOX7 ADAMTS9 RASGRP3 GRK5 THSD1 PDE10A	2.18e-06	193	87	6	ad2df9b77999780860141be6ec366afc0172a331
ToppCell	LV-01._Fibroblast_I\|LV / Chamber and Cluster_Paper	COL5A1 ARHGAP6 SPATA6 CARMIL1 GRK5 UGGT2	2.18e-06	193	87	6	dc17f3b9758936d428cf17f77a1ce6d4c479b165
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature5_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	DOCK5 ARHGAP6 FAT4 SPATA6 CARMIL1 PRKCB	2.25e-06	194	87	6	b1bb0f846d2865efdd9bc8842b16b9d069785882
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	HLA-DRA RASGRP3 SIPA1L3 MICAL3 BTLA SNX9	2.31e-06	195	87	6	0c49d22c348aec6d8a1a976e7c88d0a3b48a4244
ToppCell	Control-Myeloid-ncMonocyte\|Control / Disease state, Lineage and Cell class	DOCK5 LRRC25 INSR PRKCB MED13L SNX9	2.31e-06	195	87	6	fcb05948e7480dc53f06f3fc9b9c3fc129874edd
ToppCell	control-Lymphocytic-B_cells_1\|Lymphocytic / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	HLA-DRA RASGRP3 SIPA1L3 PRKCB BTLA ALOX5	2.31e-06	195	87	6	ff7956624b36df34e55295b295a71585accf07bd
ToppCell	mild_COVID-19-B_naive\|mild_COVID-19 / disease group, cell group and cell class (v2)	HLA-DRA RASGRP3 SIPA1L3 MICAL3 BTLA SNX9	2.38e-06	196	87	6	00398079d3ac14dc2026c0cbd7388f1f3257b134
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-lymphocytic-B_lymphocytic\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	HLA-DRA RASGRP3 CARMIL1 PRKCB MICAL3 BTLA	2.46e-06	197	87	6	fa3cc33c975648172feabb485c3bdd087f1f8ea7
ToppCell	PCW_13-14-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	KLHL3 SPATA6 CARMIL1 GRK5 PRKCB AFDN	2.46e-06	197	87	6	0034bae02ee7fcfea520d453ca3c842ab6963b12
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_fibroblastic-mes_immature1_(0)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	KLHL3 FAT4 SPATA6 CARMIL1 GRK5 PRKCB	2.46e-06	197	87	6	11a4c417f035e554431a8f03be13b5eefa3530c0
ToppCell	Tracheal-NucSeq-Immune_Lymphocytic-B-B_cell-B_mature\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	HLA-DRA RASGRP3 PRKCB MICAL3 BTLA ALOX5	2.53e-06	198	87	6	863765ccc0205dc28864dae85af339c283194c96
ToppCell	MS-IIF-Lymphocyte-B\|IIF / Disease, condition lineage and cell class	HLA-DRA RASGRP3 PRKCB MICAL3 BTLA SNX9	2.68e-06	200	87	6	a0f3362b7ddfc122e30e75fb541bb0b7d0321c72
ToppCell	facs-Marrow-T-cells-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITPKC LRRC25 ADAMTS9 GRK5 ALOX5	1.07e-05	148	87	5	b4632029ebd14969bda59a1bd1454eadb8efe563
ToppCell	facs-Marrow-T-cells-3m-Myeloid-granulocyte\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ITPKC LRRC25 ADAMTS9 GRK5 ALOX5	1.07e-05	148	87	5	ba277c898678dd36f8dc1d681301c71901b89055
ToppCell	368C-Myeloid-Macrophage-FABP4+_Macrophage_2\|368C / Donor, Lineage, Cell class and subclass (all cells)	ACO1 NAGLU ACOT4 LY75 ALOX5	1.56e-05	160	87	5	ac3f56f8ab8efd11c4b4868a828db05c23ac762f
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	HLA-DRA RASGRP3 PRKCB SNX9 ALOX5	1.71e-05	163	87	5	6bed27d2f67a430a847da5eb47878d14b4949c45
ToppCell	PBMC-Mild-Lymphocyte-B-B_cell-B_naive-B_naive-4\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	HLA-DRA RASGRP3 CARMIL1 MICAL3 BTLA	2.21e-05	172	87	5	62ed3b70fa1f6c84ea80ff00f60d2562be292e9d
ToppCell	PBMC_fresh-frozen-Mild-Moderate_progression_d02_child-Lymphocytic-Lymphocytic_B-B_cell\|Mild-Moderate_progression_d02_child / Compartment, severity and other cell annotations on 10x 3' data (130k)	HLA-DRA RASGRP3 PRKCB SNX9 ALOX5	2.27e-05	173	87	5	d56e337eae727a29cd53cfd628e1b3c0a98e1f51
ToppCell	Basal_cells-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	COL5A1 NECTIN1 OXGR1 UGGT2 DDX11	2.34e-05	174	87	5	a0060be3940043015dcc49a5157de5541aed24a1
ToppCell	Control-B_cells-B_cells\|Control / group, cell type (main and fine annotations)	RASGRP3 TMEM131L PRKCB MICAL3 BTLA	2.47e-05	176	87	5	d2c353783bd78dc24f28e00d917b88d8294fb5df
ToppCell	Adult-Endothelial-endothelial_cell_of_lymph_vessel-D231\|Adult / Lineage, Cell type, age group and donor	KLHL3 DCHS2 ADAMTS9 RASGRP3 THSD1	2.60e-05	178	87	5	c80ca7a2d3f976089a5e71d0cd9ba9a1c0bd2815
ToppCell	Children_(3_yrs)-Immune-B_cell-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	RASGRP3 TMEM131L PRKCB MICAL3 BTLA	2.67e-05	179	87	5	31411780f1a44bf2d102f288416e97eacec4b6b6
ToppCell	IPF-Lymphoid-B\|World / Disease state, Lineage and Cell class	GRK5 TMEM131L PRKCB MICAL3 BTLA	2.75e-05	180	87	5	30f9398c9b784f49470847a025bac90687e997a1
ToppCell	Control-Lymphoid-B\|World / Disease state, Lineage and Cell class	GRK5 SIPA1L3 PRKCB MICAL3 BTLA	2.82e-05	181	87	5	9124f1a610cfc3355ad87921cd3eb5346956475d
ToppCell	nucseq-Immune-Lymphocytic_B-Lymphocytic_B-B\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	SIPA1L3 TMEM131L PRKCB MICAL3 BTLA	2.82e-05	181	87	5	8d8cc4dae2c8bd5f4b1c159f2a52edc4c9449c86
ToppCell	saliva-Severe-critical_progression_d12-22_with-steroid-Myeloid-Granulocytic-Neutrophil-Neu_c1-IL1B\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	MTF1 ALOX5 CNN2 DSE TULP2	2.90e-05	182	87	5	dc32f8f6a3b13918eb8e93c018f5823d86344080
ToppCell	Influenza_Severe-B_naive\|World / Disease group and Cell class	HLA-DRA RASGRP3 MICAL3 BTLA SNX9	2.90e-05	182	87	5	e4885a5e6065c9c403cb2d305228691d6ae4ecb6
ToppCell	IPF-Myeloid-DC_Langerhans\|World / Disease state, Lineage and Cell class	DOCK5 RASGRP3 SIPA1L3 PRKCB AFDN	2.90e-05	182	87	5	0e8cfbd8ea196f27a227dbb4d2eb93bc48d27922
ToppCell	IPF-Lymphoid-B\|IPF / Disease state, Lineage and Cell class	GRK5 TMEM131L PRKCB MICAL3 BTLA	2.97e-05	183	87	5	e37d2c015c34471a8a54a0299e94b0371e1ada5a
ToppCell	5'-GW_trimst-2-LargeIntestine-Endothelial-lymphatic_endothelial-LEC4_(STAB2+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DOCK5 KLHL3 DCHS2 RASGRP3 THSD1	2.97e-05	183	87	5	38a54216458ad57f356bb4ddf272e1af8036ddeb
ToppCell	cellseq2-Immune-Immune_Myeloid-Myeloid_Dendritic-cDC2\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ATP1B4 LRRC25 HLA-DRA ALOX5 DSE	2.97e-05	183	87	5	9840706f972387241bf1d4ba8af25efc3214a91b
ToppCell	cellseq2-Immune-Immune_Myeloid-Myeloid_Dendritic\|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	ATP1B4 LRRC25 HLA-DRA ALOX5 DSE	2.97e-05	183	87	5	409cb52cf4c967e52bf75a6680bcbe87f638c75d
ToppCell	COVID-19-APC-like\|COVID-19 / group, cell type (main and fine annotations)	HLA-DRA PRKCB BTLA LY75 ALOX5	2.97e-05	183	87	5	b8f5afaf9ff1b2b1bc60be58654d1b23859dafa9
ToppCell	nucseq-Immune-Lymphocytic_B\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	RASGRP3 SIPA1L3 TMEM131L PRKCB MICAL3	3.05e-05	184	87	5	911658e7bb499c1bbc8419eec8ff88729bc39a75
ToppCell	Control-Lymphoid-B\|Control / Disease state, Lineage and Cell class	GRK5 SIPA1L3 PRKCB MICAL3 BTLA	3.05e-05	184	87	5	de0294f879268bfd68e91adcc2adba211d221b7a
ToppCell	nucseq-Immune-Lymphocytic_B-Lymphocytic_B\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	RASGRP3 SIPA1L3 TMEM131L PRKCB MICAL3	3.05e-05	184	87	5	942b58ae7172bb5f97e55b032db9329d161854af
ToppCell	TCGA-Thryoid-Primary_Tumor-Thyroid_Papillary_Carcinoma-Classical-4\|TCGA-Thryoid / Sample_Type by Project: Shred V9	PLCD3 DCHS2 ACO1 IDS SNX9	3.05e-05	184	87	5	d9659d1e4465fec68f48a22edef443f354f6c7cf
ToppCell	IPF-Myeloid-DC_Langerhans\|IPF / Disease state, Lineage and Cell class	DOCK5 RASGRP3 SIPA1L3 PRKCB AFDN	3.13e-05	185	87	5	f8ee3cb2aa9ec70f9ce8797be2b155da27ef6464
ToppCell	droplet-Liver-Hepatocytes-21m-Endothelial\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TNPO1 SOX7 FAT4 RASGRP3 PDE10A	3.13e-05	185	87	5	efcfbf5a48b3ea9a425183e5c2eec6a9585415a0
ToppCell	droplet-Liver-Hepatocytes-21m-Endothelial-endothelial_cell_of_hepatic_sinusoid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TNPO1 SOX7 FAT4 RASGRP3 PDE10A	3.13e-05	185	87	5	642088ace9230d38b0579853c54ff4dd8b5d5df4
ToppCell	IIF-Lymphocyte-B-B_naive\|IIF / Disease, Lineage and Cell Type	HLA-DRA RASGRP3 MICAL3 BTLA SNX9	3.13e-05	185	87	5	dec48908addfc71f32f5ce0ce73f2926e476f60b
ToppCell	COPD-Lymphoid-B\|World / Disease state, Lineage and Cell class	GRK5 PRKCB MICAL3 BTLA SNX9	3.13e-05	185	87	5	22891ed75e25ef30dfa541cb82d85e08ce07e7d9
ToppCell	Children_(3_yrs)-Immune-B_cell\|Children_(3_yrs) / Lineage, Cell type, age group and donor	RASGRP3 TMEM131L PRKCB MICAL3 BTLA	3.21e-05	186	87	5	aa576748921a318798b911a611f05319b95e8d5e
ToppCell	LA-01._Fibroblast_I\|World / Chamber and Cluster_Paper	COL5A1 SPATA6 CARMIL1 GRK5 UGGT2	3.30e-05	187	87	5	4ea486991f66c29728d127171a07b81404ec0b78
ToppCell	PBMC_fresh-frozen-Severe-critical_convalescent_d42-56-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Severe-critical_convalescent_d42-56 / Compartment, severity and other cell annotations on 10x 3' data (130k)	HLA-DRA RASGRP3 SIPA1L3 MICAL3 BTLA	3.30e-05	187	87	5	d01926be1c8846a25fb6706e26b56b808b69f8f0
ToppCell	Children_(3_yrs)-Endothelial-capillary_endothelial_cell_(Cap1)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	SOX7 FAT4 RASGRP3 THSD1 PDE10A	3.38e-05	188	87	5	117dc80fa940e6aa1b0187a43fdde33f3fcb578f
ToppCell	normal-na-Lymphocytic_B-B_naive-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	HLA-DRA RASGRP3 CARMIL1 MICAL3 BTLA	3.38e-05	188	87	5	ec72ba73b10c6f2ff39699b6b46b90a3e95a4c24
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-B_cell-B_c01-TCL1A\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	HLA-DRA SIPA1L3 MICAL3 BTLA SNX9	3.38e-05	188	87	5	d8decd9b5967873ca8320c2f9f07365f163c777f
ToppCell	facs-Trachea-nan-3m-Endothelial\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX7 ADAMTS9 RASGRP3 AFDN THSD1	3.47e-05	189	87	5	f60ac60ab9b317a0196f0cbbe520ef7dbd19ac11
ToppCell	CTRL-Lymphoid-B_cell\|Lymphoid / Disease state, Lineage and Cell class	HLA-DRA RASGRP3 SIPA1L3 TMEM131L MICAL3	3.47e-05	189	87	5	14f3a8c0f4f057ad4e6839b4c3eeaf956d6dc92e
ToppCell	facs-Trachea-nan-3m-Endothelial-endothelial_cell\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX7 ADAMTS9 RASGRP3 AFDN THSD1	3.47e-05	189	87	5	e3d65417997bdd3f9c312c0977dceb6eca061029
ToppCell	facs-Trachea-nan-3m-Endothelial-nan\|Trachea / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SOX7 ADAMTS9 RASGRP3 AFDN THSD1	3.47e-05	189	87	5	5559af03d9d612bb8dcf825e45744a9f8332bac8
ToppCell	COPD-Myeloid-ncMonocyte\|World / Disease state, Lineage and Cell class	DOCK5 LRRC25 INSR PRKCB SNX9	3.56e-05	190	87	5	aece860b5609ad5a8fc920d685f0d0ec71bf9018
ToppCell	BAL-Severe-Myeloid-TRAM-TRAM1-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ARHGAP6 ACO1 HLA-DRA ACOT4 ALOX5	3.56e-05	190	87	5	0eef5a8bd88ef8a25a67d9dd522d9472fa4b3d2f
ToppCell	COVID-19-Endothelial_cells-Endothelial_cells_(general)\|COVID-19 / group, cell type (main and fine annotations)	SOX7 ADAMTS9 GRK5 THSD1 PDE10A	3.56e-05	190	87	5	812e11314c76c0179fbe5a9bea29b41ce5cbc93d
ToppCell	BAL-Severe-Myeloid-TRAM-TRAM1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ARHGAP6 ACO1 HLA-DRA ACOT4 ALOX5	3.56e-05	190	87	5	2724e8f375d8d9f5f2a77444e0491af264babac5
ToppCell	Adult-Endothelial-endothelial_cell_of_lymph_vessel\|Adult / Lineage, Cell type, age group and donor	KLHL3 ADAMTS9 RASGRP3 MICAL3 THSD1	3.56e-05	190	87	5	91bf3b7e9148589757436a53a4f58e0ebfe54400
ToppCell	IPF-Myeloid-ncMonocyte\|World / Disease state, Lineage and Cell class	DOCK5 LRRC25 INSR CDH23 PRKCB	3.56e-05	190	87	5	f9c2a13c7f6460e3b348581be855b7281c8f70b5
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-B_cell-B_c03-CD27-AIM2\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	HLA-DRA RASGRP3 PRKCB AFDN MICAL3	3.56e-05	190	87	5	0db545a4cba7534bad2693e0d565cde7dbc7a586
ToppCell	BAL-Severe-Myeloid-TRAM-TRAM1-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ARHGAP6 ACO1 HLA-DRA ACOT4 ALOX5	3.56e-05	190	87	5	11fbd4e9f02750354b3aadf30edc991f8d4f8f41
ToppCell	BAL-Severe-Myeloid-TRAM-TRAM1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ARHGAP6 ACO1 HLA-DRA ACOT4 ALOX5	3.56e-05	190	87	5	148d43dd72e2e22b2cd68e17fedae6bd98b32aee
ToppCell	Endothelial-A-Myositis-ILD_01\|World / lung cells shred on cell class, cell subclass, sample id	SOX7 FAT4 ADAMTS9 GRK5 PDE10A	3.65e-05	191	87	5	f702dfe88a9b04091dae87df61b2b4f43525f86a
ToppCell	Severe_COVID-19-Myeloid-TRAM1\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	ARHGAP6 ACO1 HLA-DRA ACOT4 ALOX5	3.65e-05	191	87	5	bd641aab36276dd952a7265ee79ba455b38d8e6b
ToppCell	BAL-Severe-Myeloid-TRAM-TRAM3\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	ARHGAP6 ACO1 CHDH ACOT4 ALOX5	3.65e-05	191	87	5	2b10a73c5d80e83d67a7121fb004a1aa86a537ef
ToppCell	BAL-Severe-Myeloid-TRAM-TRAM3-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	ARHGAP6 ACO1 CHDH ACOT4 ALOX5	3.65e-05	191	87	5	02e1ae144da7274171e055356d10e8d175c5347f
ToppCell	Severe_COVID-19-Myeloid-TRAM3\|Severe_COVID-19 / Disease group,lineage and cell class （2021.01.30）	ARHGAP6 ACO1 CHDH ACOT4 ALOX5	3.65e-05	191	87	5	05867b96199a46a415848409130697c810d18937
ToppCell	5'-Adult-LargeIntestine-Epithelial-Tuft-related-Tuft\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CARMIL1 GRK5 CHDH POLR2A ALOX5	3.65e-05	191	87	5	54f07e4de61735051498846afb44b1798bed8144
ToppCell	BAL-Severe-Myeloid-TRAM\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	ARHGAP6 ACO1 CHDH ACOT4 ALOX5	3.65e-05	191	87	5	4c4f50a502e3f6768a89df686fa2830b83b8b33f
ToppCell	BAL-Severe-Myeloid-TRAM\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ARHGAP6 ACO1 CHDH ACOT4 ALOX5	3.65e-05	191	87	5	de7c88bb46f794291025ef121a89fcd94dea4ffe
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-B_cell\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	HLA-DRA SIPA1L3 MICAL3 BTLA SNX9	3.74e-05	192	87	5	446c61c0d6ba89c619efe87ee495951299953981
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Endothelial-blood_vessel_EC-Fetal_arterial_EC\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SOX7 ADAMTS9 RASGRP3 INSR THSD1	3.74e-05	192	87	5	5a0615fdc217554ccd611504b16e5d97628e207d
ToppCell	BAL-Severe-Myeloid-TRAM-TRAM3\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ARHGAP6 ACO1 CHDH ACOT4 ALOX5	3.74e-05	192	87	5	34505a13b8a47c9286c560122fa7861b9c331a08
ToppCell	COVID-19-Myeloid-TRAM1\|COVID-19 / Condition, Lineage and Cell class	ARHGAP6 ACO1 CHDH ACOT4 ALOX5	3.74e-05	192	87	5	52b8578699325b0d35a2d3ba36772096130ccc0c
ToppCell	BAL-Severe-Myeloid-TRAM-TRAM3-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ARHGAP6 ACO1 CHDH ACOT4 ALOX5	3.74e-05	192	87	5	57c1410ebf90c230993e065eb78385daa3360960
ToppCell	(100)_CD19+_Naive_B_cell\|World / immune cells in Peripheral Blood (logTPM normalization)	HLA-DRA RASGRP3 PRKCB MICAL3 BTLA	3.74e-05	192	87	5	ae7e6ed7b6cc1dd45bc0547783515beecad7792a
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d03-09-Lymphocytic-Lymphocytic_B-B_cell-B_c02-MS4A1-CD27\|Severe-critical_progression_d03-09 / Compartment, severity and other cell annotations on 10x 3' data (130k)	HLA-DRA RASGRP3 RAB3IP MICAL3 SNX9	3.83e-05	193	87	5	bbea475d2c4c7b29674ff302529f8f83dd666dcb
ToppCell	10x_3'_v3-blood_(10x_3'_v3)-lymphocytic-B_lymphocytic\|blood_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	HLA-DRA RASGRP3 CARMIL1 MICAL3 BTLA	3.83e-05	193	87	5	ddc06227f2580774d9f34729dff912d6a9155f9c
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_B\|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)	HLA-DRA RASGRP3 PRKCB MICAL3 SNX9	3.83e-05	193	87	5	ac227ddabfb3f021b1b39dba73f898517cd5a58e
ToppCell	COPD-Myeloid-ncMonocyte\|COPD / Disease state, Lineage and Cell class	DOCK5 LRRC25 INSR PRKCB SNX9	3.83e-05	193	87	5	936ca95995599356b794fba32bfd82d8de339365
Drug	Vanadium	CDK8 COL5A1 ATP1B4 ARNT ACO1 PRKCB PRKCI ITGA3	3.03e-07	173	86	8	ctd:D014639
Disease	mean platelet volume	TNPO1 DOCK5 RBBP5 ZPR1 CARMIL1 GRK5 POLR2A KIF28P TMEM131L LY75 TASOR CNN2 DSE CABLES1	1.42e-06	1020	86	14	EFO_0004584
Disease	alanine measurement	TNPO1 SF3B3 ZPR1 MLXIP ALOX5	5.41e-06	86	86	5	EFO_0009765
Disease	bilirubin measurement	TNPO1 DCHS2 FAT4 MTF1 HLA-DRA ZPR1 CARMIL1 SIPA1L3 MLXIP	5.81e-06	442	86	9	EFO_0004570
Disease	obesity (implicated_via_orthology)	DCHS2 FAT4 ADAMTS9 PUM2 PRKCI MED13L	4.04e-05	215	86	6	DOID:9970 (implicated_via_orthology)
Disease	triacylglycerol 56:5 measurement	DOCK5 ZPR1 PRKCB	5.92e-05	26	86	3	EFO_0010432
Disease	platelet component distribution width	DOCK5 MTF1 ZPR1 CARMIL1 GRK5 MOV10L1 TMEM131L SNX9 CABLES1 XPO7	6.96e-05	755	86	10	EFO_0007984
Disease	C-reactive protein measurement	SOX7 DCHS2 LRRC25 CELF1 HLA-DRA ZPR1 CARMIL1 NAGLU MICAL3 PDE10A GRM5 BABAM2	1.93e-04	1206	86	12	EFO_0004458
Disease	acetoacetate measurement	ZPR1 MLXIP	2.32e-04	8	86	2	EFO_0010111
Disease	AUTISM, SUSCEPTIBILITY TO, 15	CDK8 POLR2A	2.32e-04	8	86	2	C2677504
Disease	Agents acting on the renin-angiotensin system use measurement	SOX7 SF3B3 ZPR1 INSR PDE10A TASOR	4.49e-04	335	86	6	EFO_0009931
Disease	obsolete_red blood cell distribution width	TNPO1 DOCK5 SOX7 XRN2 LRRC25 RBBP5 ZPR1 CARMIL1 INSR CDH23 AFDN CNN2	5.24e-04	1347	86	12	EFO_0005192
Disease	systemic lupus erythematosus	SOX7 LRRC25 MTF1 HLA-DRA RASGRP3 CARMIL1 CDH23 PRKCB DSE	5.36e-04	799	86	9	MONDO_0007915
Disease	Alzheimer disease, gastroesophageal reflux disease	DNAH12 LRRC25 HLA-DRA GRK5 CABLES1	5.52e-04	228	86	5	EFO_0003948, MONDO_0004975
Disease	Diabetic Neuralgia	INSR GRM5	7.47e-04	14	86	2	C0751074
Disease	Diabetic Neuropathies	INSR GRM5	7.47e-04	14	86	2	C0011882
Disease	Asymmetric Diabetic Proximal Motor Neuropathy	INSR GRM5	7.47e-04	14	86	2	C0271674
Disease	Symmetric Diabetic Proximal Motor Neuropathy	INSR GRM5	7.47e-04	14	86	2	C0271673
Disease	Diabetic Mononeuropathy	INSR GRM5	7.47e-04	14	86	2	C0271678
Disease	Diabetic Autonomic Neuropathy	INSR GRM5	7.47e-04	14	86	2	C0271686
Disease	Diabetic Amyotrophy	INSR GRM5	7.47e-04	14	86	2	C0271685
Disease	Diabetic Polyneuropathies	INSR GRM5	7.47e-04	14	86	2	C0271680
Disease	Diabetic Asymmetric Polyneuropathy	INSR GRM5	7.47e-04	14	86	2	C0393835
Disease	SARS-CoV-2 antibody measurement, response to COVID-19 vaccine	COL5A1 OFCC1 MED13L	7.98e-04	62	86	3	EFO_0803360, EFO_0803362
Disease	Generalized hypotonia	CDK8 POLR2A	8.60e-04	15	86	2	C1858120
Disease	carcinoma (implicated_via_orthology)	FAT4 SALL3 PRKCI	8.76e-04	64	86	3	DOID:305 (implicated_via_orthology)
Disease	response to antineoplastic agent, response to antimicrotubule agent	TMEM131L MLXIP	9.81e-04	16	86	2	EFO_0005260, GO_0097327
Disease	triacylglycerol 56:9 measurement	ZPR1 PRKCB	1.11e-03	17	86	2	EFO_0010436
Disease	Feeding difficulties	CDK8 POLR2A	1.25e-03	18	86	2	C0232466
Disease	aspartate aminotransferase measurement	TNPO1 CELF1 ADAMTS9 RBBP5 ZPR1 CARMIL1 PRKCI LY75 LCT	1.28e-03	904	86	9	EFO_0004736
Disease	acetone measurement	SCART1 MLXIP	1.39e-03	19	86	2	EFO_0010989
Disease	monocyte count	TNPO1 HLA-DRA ZPR1 CARMIL1 NAGLU TMEM131L CDH23 MED13L LCT CNN2 CABLES1	1.55e-03	1320	86	11	EFO_0005091
Disease	triacylglycerol 54:6 measurement	ZPR1 PRKCB	1.87e-03	22	86	2	EFO_0010424
Disease	triacylglycerol 54:8 measurement	ZPR1 PRKCB	2.04e-03	23	86	2	EFO_0010426
Disease	blood urea nitrogen measurement	TNPO1 INSR OFCC1 UGGT2 MLXIP LY75	2.09e-03	452	86	6	EFO_0004741
Disease	antiphospholipid syndrome	HLA-DRA GRK5	2.22e-03	24	86	2	EFO_0002689
Disease	mean reticulocyte volume	TNPO1 ZPR1 TMEM131L TPGS1 AFDN MLXIP LY75 XPO7	2.31e-03	799	86	8	EFO_0010701
Disease	platelet measurement	CARMIL1 TMEM131L LY75 TASOR CABLES1	2.31e-03	315	86	5	EFO_0005036

Protein segments in the cluster

Peptide	Gene	Start	Entry
GMFRDFNDPSQDPDF	ACO1	341	P21399
SELNNYMPAFLDDPE	AFDN	736	P55196
YMPAFLDDPEENSLQ	AFDN	741	P55196
NSYNNEEFPDLTMFP	ARNT	771	P27540
YDNDPDLCFRMQEGS	BTLA	226	Q7Z6A9
YHLPQEFGDQDLLQM	CELF1	406	Q92879
EELSYMEFPSLDPNN	FAT4	3981	Q6V0I7
DENDNAPMFQQPHYE	CDH23	1626	Q9H251
EMNVDCPPGQYFIQD	ATP1B4	196	Q9UN42
YPLTEDMNGFQQEGF	CHDH	211	Q8NE62
DHIYGADTFNEMQPP	NAGLU	306	P54802
YDEAFAMANDPLEGF	RAB3IP	11	Q96QF0
TFNQMEDLLADFEGP	ITPKC	466	Q96DU7
AMEQVGLESLQFDYP	PUM2	226	Q8TB72
ADMNDNAPAFAQPEY	PCDHA6	446	Q9UN73
EEYFNPNFELGNRDM	ANKRD13B	341	Q86YJ7
QSEFEGFEYINPLLM	PRKCI	576	P41743
FAINHYGQPDVAMFD	MICAL3	356	Q7RTP6
FDENGDSPGRYEIMN	GRM5	456	P41594
NYPNEDGFSPNNDDM	MED13L	2011	Q71F56
INPEFEQAYNFEPMD	MOV10L1	616	Q9BXT6
DYENMFVGQPAAEHQ	LRRC25	241	Q8N386
EEYLAFLQQPSENMD	ATXN3L	56	Q9H3M9
GQMDVDENFYPDLLV	ITGA3	436	P26006
EIELFHFDIGPFENM	PDE10A	461	Q9Y233
FFVNPGEDDLSQIMF	CRHR2	326	Q13324
NLMFGDYMNPDLEGD	DNAH12	2181	Q6ZR08
NNGMPLAREDEFLYG	LCT	1361	P09848
YAQGVNEDEIMLPSF	LY75	1706	O60449
DENPEVMIPFTNANY	DSE	26	Q9UL01
GLFYNEDNKEDPMSA	KLHL40	366	Q2TBA0
LYEMLAGQAPFEGED	PRKCB	531	P05771
LKFVMDGGYLDQPDN	INSR	1246	P06213
PFYNHEQMGLLRDEA	DDX11	316	Q96FC9
MNLELLESFGQNYPE	RBBP5	1	Q15291
EIGIEDMNNYAPEFT	DCHS2	2536	Q6V1P9
GNEYGRNYFDPLMDE	OFCC1	86	Q8IZS5
MNEPLDYLANASDFP	OXGR1	1	Q96P68
ENYEALFMVPPDLQN	ARHGAP6	596	O43182
PNLDFMDTFEPFQDL	MLXIP	321	Q9HAP2
GDYFIEPLQSMDEQE	ADAMTS9	181	Q9P2N4
GEDAELFMALYDPDQ	DOCK5	236	Q9H7D0
LEEPQYGENMEIYAG	BABAM2	146	Q9NXR7
LGDFMDYDPNLLDDP	CABLES1	451	Q8TDN4
YMVHEEFNPDQANGS	C7orf57	126	Q8NEG2
QLPQHFVDAYLDEMD	CYP2R1	271	Q6VVX0
FLGSNDEEMSYDNNP	COL5A1	1766	P20908
EFYLNPDQSGEFMFD	HLA-DRA	36	P01903
YMLDSDPDNNGFINE	TMEM30A	241	Q9NV96
ANAYAEQHFPEVMLG	KLHL3	171	Q9UH77
GDDLSHMYNFLAQPN	CARMIL1	351	Q5VZK9
DEALRPFQMDYFGGL	LINC00526	11	Q96FQ7
ELYFVDSDPLQDHNM	IDS	521	P22304
NFPMRDGIDDESYGQ	HDAC2	226	Q92769
YNMGNPGFEEERALF	GRK5	276	P34947
SEQAMQDPYFLEDPL	CDK8	326	P49336
LPEGFQDAMDSELAY	SALL3	771	Q9BXA9
MQELYQRFLDGDHGP	KIF28P	606	B7ZC32
QSNDMPFDELLALYG	MIER2	81	Q8N344
RVMYDFAAEPGNNEL	SNX9	6	Q9Y5X1
DMDRNEFDQYLNTPG	SOX7	326	Q9BT81
LELNDYNAFPEENMN	TMEM131L	1461	A2VDJ0
EENMNYANGFPCPAD	TMEM131L	1471	A2VDJ0
GMLYIPQDFNSIEDE	BMT2	336	Q1RMZ1
FQENELFLGMYPEEH	ALOX5	611	P09917
MGEHSPDNNIIYFEA	MTF1	1	Q14872
EMFDDNGELDNSYLP	RASGRP3	21	Q8IV61
YNADFDGDEMNLHLP	POLR3A	496	O14802
QGMPEQSFFDILNEF	SIPA1L3	211	O60292
QFSPLSDYEGQEEEM	TASOR	631	Q9UK61
LPNNMDNISLEYFEE	ACOT4	196	Q8N9L9
VSYGMNPVDLFEAND	CNN2	96	Q99439
NDYTENGIEFDPMLD	TNMD	246	Q9H2S6
AHFIMDDPAGNSYLQ	ZPR1	401	O75312
NPGMDGDCVYENLAF	TULP2	196	O00295
MEFEPFGNLDQPDLY	TRAPPC12	446	Q8WVT3
ALNFQTPGYEMDLNA	PLCD3	611	Q8N3E9
PYNADFDGDEMNLHL	POLR2A	491	P24928
MLDLPGYFGSNEEDE	THSD1	826	Q9NS62
PNPNDVEFDNLYLDM	XRN2	41	Q9H0D6
PDEHVQPQLMFDYDG	SLU7	151	O95391
DKYADDIDMPGQNFD	SLU7	241	O95391
VSQGYDEAAFPLEEM	SCART1	1011	Q4G0T1
GELVYFEMDPSGQLN	SF3B3	561	Q15393
LMTENPYHNEPGFEQ	UBE2Z	216	Q9H832
AQPDQYEAPDKDFMI	TNPO1	636	Q92973
GEDEDQYEQFMLPLT	XPO7	681	Q9UIA9
DMQLNPDGEYRFILH	ZBED9	381	Q6R2W3
ALYNGEPFKHEEMNI	UGGT2	621	Q9NYU1
EEPIAFLAHYFENMG	TPGS1	61	Q6ZTW0
YDENTRDFMFPGPNQ	SPATA6	101	Q9NWH7
PMAQNLQYPDDSDDE	NECTIN1	411	Q15223