Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	negative regulation of interleukin-10 production	FCGR2B EPX VSIR PDCD1LG2	2.27e-06	26	75	4	GO:0032693
GeneOntologyBiologicalProcess	cytokine production	IL12RB2 FCGR2C SULF2 CD6 BRCA1 ADAMTS3 FCGR2B LRRK2 MUC16 REL EPX VSIR KLHL22 PDCD1LG2	3.36e-05	1091	75	14	GO:0001816
GeneOntologyBiologicalProcess	regulation of cytokine production	IL12RB2 FCGR2C SULF2 CD6 BRCA1 FCGR2B LRRK2 MUC16 REL EPX VSIR KLHL22 PDCD1LG2	6.47e-05	1010	75	13	GO:0001817
GeneOntologyCellularComponent	BRCA1-B complex	BRIP1 BRCA1	8.00e-05	4	77	2	GO:0070532
Domain	Mediator_Med12	MED12L MED12	1.59e-05	2	75	2	IPR019035
Domain	Med12	MED12L MED12	1.59e-05	2	75	2	PF09497
Domain	Mediator_Med12_LCEWAV	MED12L MED12	1.59e-05	2	75	2	IPR021990
Domain	Mediator_Med12_catenin-bd	MED12L MED12	1.59e-05	2	75	2	IPR021989
Domain	Med12-PQL	MED12L MED12	1.59e-05	2	75	2	PF12144
Domain	Med12-LCEWAV	MED12L MED12	1.59e-05	2	75	2	PF12145
Domain	Med12	MED12L MED12	1.59e-05	2	75	2	SM01281
Pubmed	IkappaBalpha overexpression delays tumor formation in v-rel transgenic mice.	NFKBIB REL	5.23e-06	2	80	2	9221757
Pubmed	Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium.	FCGR2C FCGR2B	5.23e-06	2	80	2	2531080
Pubmed	Oncogenic RAS regulates BRIP1 expression to induce dissociation of BRCA1 from chromatin, inhibit DNA repair, and promote senescence.	BRIP1 BRCA1	5.23e-06	2	80	2	22137763
Pubmed	FANCJ helicase controls the balance between short- and long-tract gene conversions between sister chromatids.	BRIP1 BRCA1	5.23e-06	2	80	2	28911102
Pubmed	Kinetic analysis of interaction of BRCA1 tandem breast cancer c-terminal domains with phosphorylated peptides reveals two binding conformations.	BRIP1 BRCA1	5.23e-06	2	80	2	18717574
Pubmed	Comprehensive Mutational Analysis of the BRCA1-Associated DNA Helicase and Tumor-Suppressor FANCJ/BACH1/BRIP1.	BRIP1 BRCA1	5.23e-06	2	80	2	33619228
Pubmed	Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling.	BRIP1 BRCA1	5.23e-06	2	80	2	15125843
Pubmed	Expression of functional CD32 molecules on human NK cells is determined by an allelic polymorphism of the FcgammaRIIC gene.	FCGR2C FCGR2B	5.23e-06	2	80	2	9516136
Pubmed	Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains.	BRIP1 BRCA1	5.23e-06	2	80	2	15242590
Pubmed	BRCA1-mediated repression of mutagenic end-joining of DNA double-strand breaks requires complex formation with BACH1.	BRIP1 BRCA1	5.23e-06	2	80	2	22032289
Pubmed	Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer.	BRIP1 BRCA1	5.23e-06	2	80	2	15133502
Pubmed	Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.	IL12RB2 CRTC3 CD6 FCGR2B LRRK2 REL USF1	1.44e-05	342	80	7	23128233
Pubmed	Loss of MED12 activates the TGFβ pathway to promote chemoresistance and replication fork stability in BRCA-deficient cells.	BRCA1 MED12	1.57e-05	3	80	2	34871431
Pubmed	Ring finger protein 6 enhances chemo-resistance by transcriptionally activating proliferating cell nuclear antigen expression and attenuating DNA damage in lung adenocarcinoma.	TCF4 RNF6	1.57e-05	3	80	2	35278611
Pubmed	Characterization of cancer-linked BRCA1-BRCT missense variants and their interaction with phosphoprotein targets.	BRIP1 BRCA1	1.57e-05	3	80	2	19452558
Pubmed	BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function.	BRIP1 BRCA1	1.57e-05	3	80	2	11301010
Pubmed	FANCJ (BACH1) helicase forms DNA damage inducible foci with replication protein A and interacts physically and functionally with the single-stranded DNA-binding protein.	BRIP1 BRCA1	1.57e-05	3	80	2	17596542
Pubmed	Pathogenicity of the BRCA1 missense variant M1775K is determined by the disruption of the BRCT phosphopeptide-binding pocket: a multi-modal approach.	BRIP1 BRCA1	1.57e-05	3	80	2	18285836
Pubmed	BRCA1 and FancJ cooperatively promote interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1.	BRIP1 BRCA1	1.57e-05	3	80	2	25483079
Pubmed	CtIP- and ATR-dependent FANCJ phosphorylation in response to DNA strand breaks mediated by DNA replication.	BRIP1 BRCA1	1.57e-05	3	80	2	23157317
Pubmed	CDCA2 protects against oxidative stress by promoting BRCA1-NRF2 signaling in hepatocellular carcinoma.	CDCA2 BRCA1	1.57e-05	3	80	2	34103686
Pubmed	Nonallelic homologous recombination of the FCGR2/3 locus results in copy number variation and novel chimeric FCGR2 genes with aberrant functional expression.	FCGR2C FCGR2B	1.57e-05	3	80	2	26133275
Pubmed	FANCJ compensates for RAP80 deficiency and suppresses genomic instability induced by interstrand cross-links.	BRIP1 BRCA1	1.57e-05	3	80	2	32797166
Pubmed	Genomic pathology of SLE-associated copy-number variation at the FCGR2C/FCGR3B/FCGR2B locus.	FCGR2C FCGR2B	1.57e-05	3	80	2	23261299
Pubmed	A novel breast cancer-associated BRIP1 (FANCJ/BACH1) germ-line mutation impairs protein stability and function.	BRIP1 BRCA1	1.57e-05	3	80	2	18628483
Pubmed	Inhibition of NF-kappaB activity by IkappaBbeta in association with kappaB-Ras.	NFKBIB REL	1.57e-05	3	80	2	15024091
Pubmed	Functional Fcgamma receptor polymorphisms are associated with human allergy.	FCGR2C FCGR2B	1.57e-05	3	80	2	24586589
Pubmed	Polymorphisms in BRCA1, BRCA1-interacting genes and susceptibility of breast cancer in Chinese women.	BRIP1 BRCA1	1.57e-05	3	80	2	19484476
Pubmed	The Eyes Absent family members EYA4 and EYA1 promote PLK1 activation and successful mitosis through tyrosine dephosphorylation.	TCF4 ALMS1 DTX2 R3HDM1 TAB3	2.76e-05	152	80	5	38360978
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CDCA2 CRTC3 UBAP2 ALMS1 SIPA1L3 R3HDM1 LYST GLCCI1 TAB3 RUSC2	2.83e-05	861	80	10	36931259
Pubmed	A functional role of I kappa B-epsilon in endothelial cell activation.	NFKBIB REL	3.13e-05	4	80	2	10706725
Pubmed	ADAMTS-3, -13, -16, and -19 levels in patients with habitual abortion.	ADAMTS3 ADAMTS13	3.13e-05	4	80	2	28088271
Pubmed	Expression of ADAMTS-2, -3, -13, and -14 in culprit coronary lesions in patients with acute myocardial infarction or stable angina.	ADAMTS3 ADAMTS13	3.13e-05	4	80	2	22205175
Pubmed	RNF6 Promotes Colorectal Cancer by Activating the Wnt/β-Catenin Pathway via Ubiquitination of TLE3.	TCF4 RNF6	3.13e-05	4	80	2	29374067
Pubmed	Targeting the FANCJ-BRCA1 interaction promotes a switch from recombination to poleta-dependent bypass.	BRIP1 BRCA1	3.13e-05	4	80	2	20173781
Pubmed	Gene expression profiling reveals activation of the FA/BRCA pathway in advanced squamous cervical cancer with intrinsic resistance and therapy failure.	BRIP1 BRCA1	3.13e-05	4	80	2	24708616
Pubmed	Comparison of the structures and peptide binding specificities of the BRCT domains of MDC1 and BRCA1.	BRIP1 BRCA1	3.13e-05	4	80	2	20159462
Pubmed	Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5/STK9) gene are associated with severe neurodevelopmental retardation.	CDKL5 CDKL2	3.13e-05	4	80	2	15499549
Pubmed	The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cells.	BRIP1 BRCA1	3.13e-05	4	80	2	17581638
Pubmed	Leucine-rich repeat kinase 2 regulates Sec16A at ER exit sites to allow ER-Golgi export.	LRRK2 SEC31A	3.13e-05	4	80	2	25201882
Pubmed	Impact of RING and BRCT domain mutations on BRCA1 protein stability, localization and recruitment to DNA damage.	BRIP1 BRCA1	3.13e-05	4	80	2	20681793
Pubmed	Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure.	BRIP1 BRCA1	3.13e-05	4	80	2	11877378
Pubmed	Insight into the roles of helicase motif Ia by characterizing Fanconi anemia group J protein (FANCJ) patient mutations.	BRIP1 BRCA1	3.13e-05	4	80	2	24573678
Pubmed	RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy.	SMG7 ALMS1 ATXN2 EFR3B R3HDM1 TAB3	3.32e-05	263	80	6	34702444
Pubmed	Migration-induced cell shattering due to DOCK8 deficiency causes a type 2-biased helper T cell response.	DOCK8 EPX	5.20e-05	5	80	2	33020661
Pubmed	Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response.	BRIP1 BRCA1	5.20e-05	5	80	2	17525342
Pubmed	Fanconi anemia group J helicase and MRE11 nuclease interact to facilitate the DNA damage response.	BRIP1 BRCA1	5.20e-05	5	80	2	23530059
Pubmed	Copy number variation at the FCGR locus includes FCGR3A, FCGR2C and FCGR3B but not FCGR2A and FCGR2B.	FCGR2C FCGR2B	5.20e-05	5	80	2	19309690
Pubmed	Atypical mechanism of NF-κB activation by TRE17/ubiquitin-specific protease 6 (USP6) oncogene and its requirement in tumorigenesis.	USP6 NFKBIB	5.20e-05	5	80	2	22081069
Pubmed	Combining Homologous Recombination and Phosphopeptide-binding Data to Predict the Impact of BRCA1 BRCT Variants on Cancer Risk.	BRIP1 BRCA1	5.20e-05	5	80	2	30257991
Pubmed	SNPs of Fc-gamma receptor genes and chronic periodontitis.	FCGR2C FCGR2B	5.20e-05	5	80	2	20439936
Pubmed	Copy number, linkage disequilibrium and disease association in the FCGR locus.	FCGR2C FCGR2B	5.20e-05	5	80	2	20508037
Pubmed	Activation of BRCA1/BRCA2-associated helicase BACH1 is required for timely progression through S phase.	BRIP1 BRCA1	5.20e-05	5	80	2	17664283
Pubmed	IkappaBbeta acts to inhibit and activate gene expression during the inflammatory response.	NFKBIB REL	7.79e-05	6	80	2	20740013
Pubmed	Crosstalk between BRCA-Fanconi anemia and mismatch repair pathways prevents MSH2-dependent aberrant DNA damage responses.	BRIP1 BRCA1	7.79e-05	6	80	2	24966277
Pubmed	The BRCT domain is a phospho-protein binding domain.	BRIP1 BRCA1	7.79e-05	6	80	2	14576433
Pubmed	BRCT repeats as phosphopeptide-binding modules involved in protein targeting.	BRIP1 BRCA1	7.79e-05	6	80	2	14576432
Pubmed	Basal phosphorylation of the PEST domain in the I(kappa)B(beta) regulates its functional interaction with the c-rel proto-oncogene product.	NFKBIB REL	7.79e-05	6	80	2	8887627
Pubmed	I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activity.	NFKBIB REL	7.79e-05	6	80	2	9135156
Pubmed	HP1 regulates the localization of FANCJ at sites of DNA double-strand breaks.	BRIP1 BRCA1	7.79e-05	6	80	2	27399284
Pubmed	Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3.	MED12L MED12	7.79e-05	6	80	2	11524702
Pubmed	Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response.	BRIP1 BRCA1	7.79e-05	6	80	2	17525340
Pubmed	NF-kappa B: ten years after.	NFKBIB REL	7.79e-05	6	80	2	8858144
Pubmed	NF-kappaB subunit p65 binds to 53BP2 and inhibits cell death induced by 53BP2.	NFKBIB REL	7.79e-05	6	80	2	10498867
Pubmed	PALB2 is an integral component of the BRCA complex required for homologous recombination repair.	BRIP1 BRCA1	7.79e-05	6	80	2	19369211
Pubmed	FANCJ/BACH1 acetylation at lysine 1249 regulates the DNA damage response.	BRIP1 BRCA1	7.79e-05	6	80	2	22792074
Pubmed	Kin-cohort estimates for familial breast cancer risk in relation to variants in DNA base excision repair, BRCA1 interacting and growth factor genes.	BRIP1 BRCA1	7.79e-05	6	80	2	15113441
Pubmed	FancJ (Brip1) loss-of-function allele results in spermatogonial cell depletion during embryogenesis and altered processing of crossover sites during meiotic prophase I in mice.	BRIP1 BRCA1	7.79e-05	6	80	2	26490168
Pubmed	Human transcription factor protein interaction networks.	CDCA2 TCF4 PHC3 UBAP2 SMG7 ALMS1 BRCA1 ATXN2 NFKBIB REL R3HDM1 TAB3	1.00e-04	1429	80	12	35140242
Pubmed	Screening for BRCA1, BRCA2, CHEK2, PALB2, BRIP1, RAD50, and CDH1 mutations in high-risk Finnish BRCA1/2-founder mutation-negative breast and/or ovarian cancer individuals.	BRIP1 BRCA1	1.09e-04	7	80	2	21356067
Pubmed	RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites.	BRIP1 BRCA1	1.09e-04	7	80	2	17525341
Pubmed	Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome.	BRIP1 BRCA1	1.09e-04	7	80	2	21240188
Pubmed	Expression and subcellular distribution of rel/NF kappa B transcription factors in the preimplantation mouse embryo: novel kappa B binding activities in the blastocyst stage embryo.	NFKBIB REL	1.09e-04	7	80	2	9854797
Pubmed	Activation of the transcription factor GLI1 by WNT signaling underlies the role of SULFATASE 2 as a regulator of tissue regeneration.	TCF4 SULF2	1.09e-04	7	80	2	23740243
Pubmed	Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening.	CDKL5 FCGR2C BRCA1 FCGR2B CNTNAP1 EPX	1.14e-04	329	80	6	17474147
Pubmed	A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.	CRTC3 EAF1 SMG7 NFKBIB REL SEC31A R3HDM1 GLCCI1 MED12 RUSC2	1.33e-04	1038	80	10	26673895
Pubmed	Functional integrity of naturally occurring mutants of HIV-1 subtype C Vpr.	NFKBIB REL	1.45e-04	8	80	2	20801175
Pubmed	CK2 kinase-mediated PHF8 phosphorylation controls TopBP1 stability to regulate DNA replication.	BRIP1 BRCA1	1.45e-04	8	80	2	33010150
Pubmed	Requirement of heterogeneous nuclear ribonucleoprotein C for BRCA gene expression and homologous recombination.	BRIP1 BRCA1	1.45e-04	8	80	2	23585894
Pubmed	CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.	BRIP1 UBAP2 ALMS1 BRCA1 LMNA SEC31A KLHL22	1.45e-04	494	80	7	26831064
Pubmed	'Srcasm: a novel Src activating and signaling molecule.	BRCA1 EPX	1.86e-04	9	80	2	11711534
Pubmed	Functional and mutational landscapes of BRCA1 for homology-directed repair and therapy resistance.	BRIP1 BRCA1	1.86e-04	9	80	2	28398198
Pubmed	Uncovering the Translational Regulatory Activity of the Tumor Suppressor BRCA1.	BRCA1 FNBP4	1.86e-04	9	80	2	32290274
Pubmed	Conserved overlapping gene arrangement, restricted expression, and biochemical activities of DNA polymerase ν (POLN).	BRIP1 BRCA1	1.86e-04	9	80	2	26269593
Pubmed	A proteomic analysis of ataxia telangiectasia-mutated (ATM)/ATM-Rad3-related (ATR) substrates identifies the ubiquitin-proteasome system as a regulator for DNA damage checkpoints.	TAOK3 BRCA1	2.32e-04	10	80	2	17478428
Pubmed	Signal transduction protein array analysis links LRRK2 to Ste20 kinases and PKC zeta that modulate neuronal plasticity.	TAOK3 LRRK2	2.32e-04	10	80	2	20949042
Pubmed	ADAMTS: a novel family of extracellular matrix proteases.	ADAMTS3 ADAMTS13	2.32e-04	10	80	2	11167130
Pubmed	PARP1-driven poly-ADP-ribosylation regulates BRCA1 function in homologous recombination-mediated DNA repair.	BRIP1 BRCA1	2.32e-04	10	80	2	25252691
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	ALMS1 TMEM132A FNBP4 UNC13A	2.37e-04	130	80	4	12421765
Pubmed	Modification of ovarian cancer risk by BRCA1/2-interacting genes in a multicenter cohort of BRCA1/2 mutation carriers.	BRIP1 BRCA1	2.84e-04	11	80	2	19584272
Pubmed	Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes.	BRIP1 BRCA1	3.40e-04	12	80	2	16391231
Pubmed	A CASPR1-ATP1B3 protein interaction modulates plasma membrane localization of Na+/K+-ATPase in brain microvascular endothelial cells.	LMNA CNTNAP1	4.01e-04	13	80	2	30792309
Pubmed	The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair.	UBE4A BRCA1	4.01e-04	13	80	2	29499138
Pubmed	NOD2 is a negative regulator of Toll-like receptor 2-mediated T helper type 1 responses.	IL12RB2 REL	4.01e-04	13	80	2	15220916
Pubmed	BRCA1 tumor suppressor network: focusing on its tail.	BRIP1 BRCA1	4.01e-04	13	80	2	22369660
Pubmed	mTORC1 activity regulates post-translational modifications of glycine decarboxylase to modulate glycine metabolism and tumorigenesis.	LMNA ATXN2 SIPA1L3 PPP1R9A R3HDM1	4.34e-04	274	80	5	34244482
Pubmed	Dual Requirement of Cytokine and Activation Receptor Triggering for Cytotoxic Control of Murine Cytomegalovirus by NK Cells.	IL12RB2 LYST	4.67e-04	14	80	2	26720279
Pubmed	Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.	PHC3 CRTC3 UBAP2 LMNA ATXN2 KMT2E	4.79e-04	430	80	6	35044719
Pubmed	The Fanconi anemia family of genes and its correlation with breast cancer susceptibility and breast cancer features.	BRIP1 BRCA1	5.38e-04	15	80	2	19536649
Pubmed	Atypical heat shock transcription factor HSF5 is critical for male meiotic prophase under non-stress conditions.	BRCA1 HSF5	5.38e-04	15	80	2	38684656
Interaction	OC90 interactions	BRIP1 ALMS1 RECQL4 NPRL3	2.08e-06	24	78	4	int:OC90
Interaction	NUP50 interactions	CDCA2 BRIP1 UBAP2 LMNA RECQL4 FNBP4 PLEKHA4 DTX2 SEC31A	6.69e-06	341	78	9	int:NUP50
Interaction	LSM14A interactions	UBAP2 SMG7 ATXN2 CDKL2 RECQL4 PLEKHA4 SEC31A R3HDM1	7.41e-06	260	78	8	int:LSM14A
Interaction	LATS1 interactions	SMG7 ALMS1 LMNA CBY2 SIPA1L3 LRRK2 PLEKHA4 R3HDM1 KATNA1 TAB3	7.43e-06	440	78	10	int:LATS1
Interaction	RNF6 interactions	TCF4 BRCA1 RNF6 CBY2 REL	1.14e-05	76	78	5	int:RNF6
Interaction	MAP3K7CL interactions	REL USF1 TAB3	1.20e-05	12	78	3	int:MAP3K7CL
Interaction	YWHAH interactions	CDCA2 RMDN3 CRTC3 UBAP2 ALMS1 SIPA1L3 RECQL4 LRRK2 PLEKHA4 PRKD1 R3HDM1 LYST GLCCI1 TAB3 RUSC2	1.80e-05	1102	78	15	int:YWHAH
Interaction	YWHAG interactions	CDCA2 RMDN3 CRTC3 UBAP2 ALMS1 LMNA SIPA1L3 RECQL4 LRRK2 PLEKHA4 PRKD1 R3HDM1 LYST GLCCI1 TAB3 RUSC2	1.90e-05	1248	78	16	int:YWHAG
Interaction	ZDHHC24 interactions	TCF4 LMNA REL	1.97e-05	14	78	3	int:ZDHHC24
Interaction	YWHAQ interactions	RMDN3 CRTC3 UBAP2 BRCA1 LMNA SIPA1L3 RECQL4 LRRK2 PLEKHA4 PRKD1 R3HDM1 LYST GLCCI1 TAB3 RUSC2	2.14e-05	1118	78	15	int:YWHAQ
Interaction	PPP4R1L interactions	BRIP1 ALMS1 RECQL4 TUBA4B MED12	2.20e-05	87	78	5	int:PPP4R1L
Interaction	POLR2H interactions	BRCA1 NFKBIB RECQL4 PLEKHA4 MED12L REL MED12	2.51e-05	223	78	7	int:POLR2H
Interaction	GAR1 interactions	BRCA1 LMNA CDKL2 RECQL4 PLEKHA4 PRKD1 LYST	3.23e-05	232	78	7	int:GAR1
Interaction	TCEA2 interactions	TCF4 EAF1 BRCA1 LMNA CBY2 LRRK2	3.53e-05	159	78	6	int:TCEA2
Interaction	CDC37 interactions	CDKL5 TCF4 BRCA1 CDKL2 CBY2 NFKBIB RECQL4 LRRK2 INSRR PRKD1 STAMBPL1	3.68e-05	645	78	11	int:CDC37
Interaction	SEC16A interactions	SMG7 BRCA1 LMNA ATXN2 RECQL4 PLEKHA4 REL STAMBPL1 DTX2	3.89e-05	426	78	9	int:SEC16A
Interaction	YTHDF3 interactions	UBAP2 SMG7 BRCA1 LMNA ATXN2 LRRK2 R3HDM1	4.69e-05	246	78	7	int:YTHDF3
Interaction	KPNA3 interactions	BRCA1 LMNA NFKBIB RECQL4 PLEKHA4 REL KMT2E	4.93e-05	248	78	7	int:KPNA3
Interaction	DDX5 interactions	TCF4 BRCA1 LMNA ATXN2 CDKL2 RECQL4 CNTNAP1 PLEKHA4 DTX2 MED12	6.57e-05	568	78	10	int:DDX5
Interaction	NBN interactions	BRIP1 CD6 BRCA1 LMNA RECQL4 PLEKHA4	7.72e-05	183	78	6	int:NBN
Interaction	SCAF8 interactions	SMG7 PLEKHA4 DTX2 KLHL22	8.04e-05	59	78	4	int:SCAF8
Interaction	YWHAE interactions	RMDN3 CRTC3 BRCA1 DOCK8 SIPA1L3 RECQL4 LRRK2 PLEKHA4 PRKD1 R3HDM1 LYST GLCCI1 TAB3 KLHL22 RUSC2	8.12e-05	1256	78	15	int:YWHAE
Interaction	DCAF7 interactions	UBE4A CRTC3 BRCA1 ATXN2 RECQL4 PLEKHA4 SEC31A GLCCI1	8.82e-05	368	78	8	int:DCAF7
Interaction	FLAD1 interactions	TCF4 UBAP2 RECQL4 PLEKHA4 REL	9.49e-05	118	78	5	int:FLAD1
Interaction	KHDRBS1 interactions	BRCA1 ATXN2 RECQL4 FNBP4 PLEKHA4 DTX2 MED12 RUSC2	9.69e-05	373	78	8	int:KHDRBS1
Interaction	RBM6 interactions	SMG7 BRCA1 LMNA PLEKHA4 DTX2	9.87e-05	119	78	5	int:RBM6
Interaction	NUP37 interactions	BRCA1 LMNA RECQL4 PLEKHA4	1.18e-04	65	78	4	int:NUP37
Interaction	RBM47 interactions	UBAP2 SMG7 ATXN2 STAMBPL1 DTX2 R3HDM1	1.40e-04	204	78	6	int:RBM47
Interaction	R3HDM2 interactions	UBAP2 SMG7 ATXN2 REL R3HDM1	1.44e-04	129	78	5	int:R3HDM2
Interaction	REXO1L6P interactions	TCF4 REL	1.47e-04	5	78	2	int:REXO1L6P
Interaction	FAM111B interactions	RMDN3 PLEKHA4 DTX2	1.53e-04	27	78	3	int:FAM111B
Interaction	UBAP2L interactions	CDKL5 UBAP2 SMG7 BRCA1 ATXN2 PLEKHA4 R3HDM1	1.55e-04	298	78	7	int:UBAP2L
Interaction	CTBP1 interactions	TCF4 PHC3 BRCA1 RECQL4 PLEKHA4 NPRL3 DTX2 SEC31A	1.73e-04	406	78	8	int:CTBP1
Interaction	DGCR6 interactions	TCF4 DOCK8 CBY2 REL	1.85e-04	73	78	4	int:DGCR6
Interaction	GUSBP5 interactions	SMG7 ALMS1 ATXN2 PPP1R9A	2.05e-04	75	78	4	int:GUSBP5
Interaction	POLR1A interactions	TCF4 CD6 BRCA1 NFKBIB PLEKHA4 REL	2.11e-04	220	78	6	int:POLR1A
Interaction	C1orf56 interactions	TCF4 REL	2.20e-04	6	78	2	int:C1orf56
Interaction	ZNF148 interactions	BRCA1 LMNA RECQL4 PLEKHA4 DTX2	2.41e-04	144	78	5	int:ZNF148
Interaction	GLDC interactions	LMNA ATXN2 SIPA1L3 PPP1R9A RECQL4 PLEKHA4 R3HDM1	2.45e-04	321	78	7	int:GLDC
Interaction	RAB34 interactions	IL12RB2 BRCA1 LMNA PLEKHA4	2.50e-04	79	78	4	int:RAB34
Interaction	USP15 interactions	RMDN3 TAOK3 LMNA RECQL4 TMEM132A LRRK2 PLEKHA4 PRKD1 TAB3	2.55e-04	546	78	9	int:USP15
Interaction	PMS2 interactions	BRIP1 BRCA1 LMNA PLEKHA4	2.63e-04	80	78	4	int:PMS2
Interaction	CSNK2A1 interactions	SULF2 CD6 BRCA1 LMNA ATXN2 NFKBIB RECQL4 CPNE3 FNBP4 PLEKHA4 REL LYST	2.92e-04	956	78	12	int:CSNK2A1
Interaction	ARL16 interactions	CDCA2 TCF4 BRCA1 REL	3.03e-04	83	78	4	int:ARL16
Interaction	OTUD4 interactions	TCF4 SMG7 ATXN2 PLEKHA4 REL R3HDM1	3.08e-04	236	78	6	int:OTUD4
Interaction	R3HDM1 interactions	SMG7 ATXN2 DTX2 R3HDM1	3.17e-04	84	78	4	int:R3HDM1
Interaction	SFN interactions	CRTC3 ALMS1 LMNA SIPA1L3 RECQL4 LRRK2 DTX2 LYST TAB3 RUSC2	3.27e-04	692	78	10	int:SFN
Interaction	SMG6 interactions	RMDN3 SMG7 ATXN2 PLEKHA4	3.31e-04	85	78	4	int:SMG6
Interaction	ARMC7 interactions	TCF4 CBY2 REL DTX2	3.31e-04	85	78	4	int:ARMC7
Interaction	LARP4B interactions	UBAP2 LMNA ATXN2 RECQL4 PLEKHA4 R3HDM1	3.37e-04	240	78	6	int:LARP4B
Interaction	MDH1 interactions	ALMS1 BRCA1 LMNA LRRK2 PLEKHA4	3.59e-04	157	78	5	int:MDH1
Interaction	MLH1 interactions	CDKL5 BRIP1 BRCA1 CBY2 PLEKHA4 LYST	3.67e-04	244	78	6	int:MLH1
Interaction	ODF2 interactions	SMG7 ALMS1 BRCA1 SIPA1L3 KATNA1	3.70e-04	158	78	5	int:ODF2
Interaction	FBLN5 interactions	PHC3 SULF2 LPA RECQL4 R3HDM1	3.81e-04	159	78	5	int:FBLN5
Interaction	SPTLC1 interactions	LMNA RECQL4 PLEKHA4 SEC31A MED12	3.81e-04	159	78	5	int:SPTLC1
Interaction	CDC16 interactions	SMG7 ALMS1 BRCA1 RECQL4 PLEKHA4 MED12	3.84e-04	246	78	6	int:CDC16
GeneFamily	Ankyrin repeat domain containing\|BRCA1 B complex	BRIP1 BRCA1	4.66e-05	4	51	2	1335
GeneFamily	ADAM metallopeptidases with thrombospondin type 1 motif	ADAMTS3 ADAMTS13	1.29e-03	19	51	2	50
GeneFamily	Ring finger proteins\|Fanconi anemia complementation groups\|Protein phosphatase 1 regulatory subunits\|BRCA1 A complex\|BRCA1 B complex\|BRCA1 C complex	BRIP1 BRCA1	1.43e-03	20	51	2	548
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	CDCA2 BRCA1 CSRNP3 PPP1R9A	1.68e-03	181	51	4	694
GeneFamily	Ataxins\|Trinucleotide repeat containing	ATXN2 MED12	2.25e-03	25	51	2	775
GeneFamily	Cyclin dependent kinases	CDKL5 CDKL2	2.43e-03	26	51	2	496
GeneFamily	Cyclins\|Mediator complex	MED12L MED12	3.90e-03	33	51	2	1061
Coexpression	MANNO_MIDBRAIN_NEUROTYPES_HGABA	TAOK3 CSRNP3 MEGF9 ADAMTS3 CDKL2 PPP1R9A LRRK2 R3HDM1 KMT2E LYST CSGALNACT1 UNC13A RUSC2	2.16e-05	1106	78	13	M39071
Coexpression	GSE21033_CTRL_VS_POLYIC_STIM_DC_1H_DN	FCGR2C LMNA CDKL2 NFKBIB REL RUSC2	2.82e-05	198	78	6	M7716
Coexpression	GSE29618_PRE_VS_DAY7_POST_TIV_FLU_VACCINE_PDC_DN	UBE4A TAOK3 SMG7 RECQL4 FNBP4 R3HDM1	2.98e-05	200	78	6	M5005
Coexpression	GSE17721_PAM3CSK4_VS_GADIQUIMOD_6H_BMDC_DN	RMDN3 TCF4 LRRK2 CPNE3 REL KATNA1	2.98e-05	200	78	6	M3971
CoexpressionAtlas	FacebaseRNAseq_e8.5_Paraxial Mesoderm_top-relative-expression-ranked_2500_k-means-cluster#3	TAOK3 BRIP1 CSRNP3 MEGF9 ADAMTS3 PPP1R9A MAMLD1 CPNE3 MED12L KMT2E GLCCI1 RUSC2	1.54e-05	730	79	12	Facebase_RNAseq_e8.5_Paraxial Mesoderm_2500_K3
CoexpressionAtlas	FacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_2500_k-means-cluster#5	CDCA2 TAOK3 ALMS1 CSRNP3 MEGF9 ADAMTS3 PPP1R9A MAMLD1 CPNE3 GLCCI1 RUSC2	4.65e-05	688	79	11	Facebase_RNAseq_e10.5_Mandibular Arch_2500_K5
ToppCell	pdx\|World / Sample and Cell Type and Tumor Cluster (all cells)	TAOK3 BRIP1 BRCA1 ATXN2 SIPA1L3 NR6A1 R3HDM1	4.16e-08	186	79	7	de8e538c8767d41b8a52f5e58ba1affd4e7244c4
ToppCell	pdx-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	TAOK3 BRIP1 BRCA1 ATXN2 SIPA1L3 NR6A1 R3HDM1	4.16e-08	186	79	7	0b88a87158a9ca8de3bf40a4ff1687150707a5f0
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CDKL5 HHIP MEGF9 CDKL2 PPP1R9A LRRK2 NR6A1	6.60e-08	199	79	7	725610310e5c5fd7120c0be9acb55bf152026ddd
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CDKL5 HHIP MEGF9 CDKL2 PPP1R9A NR6A1 GLCCI1	6.60e-08	199	79	7	8587bd98de7767a575088afbea07a1feb4516b9b
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	TAOK3 LRRK2 PRKD1 STAMBPL1 GLCCI1 CSGALNACT1	9.35e-07	184	79	6	8fd8bd3d28d0ee6f0ef1f14e354d8eaf63a8081b
ToppCell	COVID-19-lung-AT2\|COVID-19 / Disease (COVID-19 only), tissue and cell type	HHIP MEGF9 CDKL2 PPP1R9A LRRK2 GLCCI1	1.13e-06	190	79	6	27a1a86620fe9b5ee930d388b32352206485e6d0
ToppCell	Control-Myeloid-cDC2\|Myeloid / Disease state, Lineage and Cell class	TCF4 SULF2 FCGR2B SIPA1L3 REL CSGALNACT1	1.24e-06	193	79	6	4cb938c346cc32ec122d11e6b9f25db20e0f7ff6
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.0.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CDKL5 HHIP MEGF9 CDKL2 PPP1R9A LRRK2	1.31e-06	195	79	6	d9694db6bf239636d1335016878c98f6ee2eb0eb
ToppCell	wk_15-18-Hematologic-Myeloid-S100A12-hi_cla._mono.\|wk_15-18 / Celltypes from embryonic and fetal-stage human lung	FCGR2C MEGF9 DOCK8 LRRK2 LYST VSIR	1.35e-06	196	79	6	aa53ae1e5d08d31cfd81b7fae46c2b5d21d4f9b2
ToppCell	LPS_only-Hematopoietic_Myeloid-Dendritic_cells\|LPS_only / Treatment groups by lineage, cell group, cell type	SULF2 DOCK8 SRD5A1 REL STAMBPL1 PDCD1LG2	1.39e-06	197	79	6	59ddd8ff7dddf3747b988374e1a4d80959db803e
ToppCell	Bronchial-NucSeq-Epithelial-Epi_alveolar-AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	HHIP CDKL2 PPP1R9A LRRK2 PRKD1 NR6A1	1.43e-06	198	79	6	f948391296c261c473d339069a6d0f20ccd6f38f
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_connecting_tubule_epithelial_cell_cycling-Cycling_Connecting_Tubule_Cell_S-high\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	BRIP1 BRCA1 RECQL4 MED12L EFR3B	1.20e-05	167	79	5	108ae6221c6edc63c0ec42c42471b3a15a594043
ToppCell	PND03-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CDKL5 ALMS1 SIPA1L3 LRRK2 STAMBPL1	1.23e-05	168	79	5	08f6e171a1ea5cf65149744296d0fcd6c7b9684e
ToppCell	3'-Adult-SmallIntestine-Hematopoietic\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CD6 DOCK8 LRRK2 MED12L REL	1.63e-05	178	79	5	da1695a936dbe3ca9ee3fb28ceb60511c47b35f8
ToppCell	3'-Adult-SmallIntestine-Hematopoietic-B_cells\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	CD6 DOCK8 LRRK2 MED12L REL	1.63e-05	178	79	5	580fc1d45b82010c665a313b2e7a21e0116819ef
ToppCell	IPF-Myeloid-pDC\|Myeloid / Disease state, Lineage and Cell class	TCF4 SULF2 SRD5A1 MED12L GLCCI1	1.72e-05	180	79	5	0f8567aa835d4e3a52f6631ae15216eca18a030c
ToppCell	Control-Epithelial_cells-AT2\|Control / group, cell type (main and fine annotations)	HHIP CDKL2 PPP1R9A LRRK2 PRKD1	1.72e-05	180	79	5	198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	HHIP CDKL2 PPP1R9A LRRK2 PRKD1	1.86e-05	183	79	5	6847c1252d6bb105524f812658112517fd351eab
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TCF4 SULF2 FCGR2B MED12L STAMBPL1	1.86e-05	183	79	5	bd78e5c2670e67b4363078e3ca5a5b7081d24b7e
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TCF4 SULF2 FCGR2B MED12L STAMBPL1	1.86e-05	183	79	5	d1bf3abf42eb9d7facf775becf1338d1faadd647
ToppCell	COVID-19-lung-AT1\|lung / Disease (COVID-19 only), tissue and cell type	MEGF9 PPP1R9A EFR3B NR6A1 GLCCI1	1.86e-05	183	79	5	942530449e9c6583705eeb8f6f12621daea57252
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Macula_Densa_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	LRRK2 PRKD1 STAMBPL1 GLCCI1 CSGALNACT1	1.91e-05	184	79	5	d33de57876817050b294f2ecb0a4eb0634cfa7f0
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	HHIP MEGF9 CDKL2 PPP1R9A LRRK2	2.07e-05	187	79	5	5df9e1f5ca32217af255e76e6fb5afa346337811
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D231\|Adult / Lineage, Cell type, age group and donor	HHIP CDKL2 PPP1R9A LRRK2 PRKD1	2.17e-05	189	79	5	dab54a52358f66a8a9460cd6089a06c5fa7e7a5d
ToppCell	IPF-Myeloid-ncMonocyte\|Myeloid / Disease state, Lineage and Cell class	SULF2 LINC00173 LRRK2 LYST VSIR	2.17e-05	189	79	5	5c22d2d935f7bb270260b8bc6be67b565ec401bf
ToppCell	(3)_DC_activated\|World / Lung cell shreds - cell class (v4) and cell subclass (v4)	SULF2 REL NR6A1 EPX PDCD1LG2	2.17e-05	189	79	5	e977838793fc0eb1499e81018e33e4ccb4a5f0c5
ToppCell	Control-Myeloid-cDC2\|Control / Disease state, Lineage and Cell class	TCF4 SULF2 FCGR2B SIPA1L3 REL	2.23e-05	190	79	5	4e481e42353d47af7991744000403af2873f6a41
ToppCell	Control-Myeloid-cDC2\|World / Disease state, Lineage and Cell class	TCF4 SULF2 FCGR2B SIPA1L3 REL	2.29e-05	191	79	5	11dfd8f38beb294f42710cfbd355cb089e1023c0
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2\|Children_(3_yrs) / Lineage, Cell type, age group and donor	HHIP CDKL2 PPP1R9A LRRK2 PRKD1	2.29e-05	191	79	5	a0332a4ef629510fb313ec119195c44a3f704a80
ToppCell	COPD-Myeloid-cDC2\|COPD / Disease state, Lineage and Cell class	SULF2 FCGR2B SIPA1L3 MAMLD1 REL	2.29e-05	191	79	5	2af6e4a6bd1f2193ece2131c3b7d976dd23a6966
ToppCell	COVID-19-lung-AT2\|lung / Disease (COVID-19 only), tissue and cell type	HHIP MEGF9 CDKL2 PPP1R9A LRRK2	2.29e-05	191	79	5	276455a64c2c3503d5048615762eb2ee37f0ac70
ToppCell	COPD-Myeloid-cDC2\|World / Disease state, Lineage and Cell class	SULF2 FCGR2B SIPA1L3 REL CSGALNACT1	2.29e-05	191	79	5	4e4887175200a57e1b041f2f131e3df774df3509
ToppCell	COPD-Myeloid-cDC2\|Myeloid / Disease state, Lineage and Cell class	SULF2 FCGR2B SIPA1L3 REL CSGALNACT1	2.34e-05	192	79	5	984cdc2f1d93e164bc946d63f58dacb629f82eb7
ToppCell	Epithelial-alveolar_epithelial_cell_type_2\|World / Lineage, Cell type, age group and donor	HHIP CDKL2 PPP1R9A LRRK2 PRKD1	2.34e-05	192	79	5	58c3737be7acce39fd2b91d70d6d7b2bbaa4f710
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CDKL5 MEGF9 PPP1R9A LRRK2 GLCCI1	2.34e-05	192	79	5	29f49f00770c991b5f27e4cb701dd2d2d6cb7178
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	CDKL5 HHIP CDKL2 PPP1R9A LRRK2	2.34e-05	192	79	5	cc9911e182a289779a2612bc213daae5607689e7
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	HHIP CDKL2 PPP1R9A LRRK2 PRKD1	2.34e-05	192	79	5	fb2f0e897228f808d9ff734ad05e9b49dc38fa50
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	HHIP CDKL2 PPP1R9A LRRK2 PRKD1	2.40e-05	193	79	5	fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCell	MNPs-Dendritic_Cells\|MNPs / lung cells shred on cell class, cell subclass, sample id	TCF4 SULF2 FCGR2B CSGALNACT1 VSIR	2.40e-05	193	79	5	0e6b8e179bfe1c6e93137c76c76a91c7782a4989
ToppCell	PCW_10-12-Mesenchymal-Mesenchymal_myocytic-mes_proliferating_SM_(20)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	CDCA2 HHIP BRIP1 BRCA1 RECQL4	2.40e-05	193	79	5	bbdfda6665941cfa1965418bb91ef9ff43b1326f
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2\|Adult / Lineage, Cell type, age group and donor	HHIP CDKL2 PPP1R9A LRRK2 PRKD1	2.40e-05	193	79	5	738f4f0a9ddde2432b429ab46838e353b1790589
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-BDM-TAM-BDM_anti-infl-E\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	OTOA DOCK8 REL VSIR HSF5	2.40e-05	193	79	5	b52d5661edff83ac4c5fe2bf89d6672016bb827b
ToppCell	nucseq-Epithelial-Epithelial_Alveolar-AT2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	HHIP CDKL2 PPP1R9A LRRK2 PRKD1	2.40e-05	193	79	5	f3cc7cfdbc164a4ed42f87647111522b7d393bcb
ToppCell	PBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	SULF2 MEGF9 LRRK2 LYST VSIR	2.40e-05	193	79	5	4fb020f11fd7aff06952bfeaabc79b2c7b8873f6
ToppCell	10x5'v1-week_17-19-Myeloid_neutrophil-granulo-neutrophil-neutrophil\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	FCGR2C MEGF9 LRRK2 LYST VSIR	2.46e-05	194	79	5	e2d0dfb92356fa7ad7008aa8ac4198e2ac5d2495
ToppCell	nucseq-Epithelial-Epithelial_Alveolar\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	HHIP PPP1R9A LRRK2 NR6A1 GLCCI1	2.46e-05	194	79	5	53f3e49e91b1096f3226010e2de767efb490dfe4
ToppCell	PBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_1\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	SULF2 MEGF9 LRRK2 LYST VSIR	2.46e-05	194	79	5	885355ebe98e974f841cc59dce3b5228c642c5d0
ToppCell	IPF-Myeloid-cDC2\|Myeloid / Disease state, Lineage and Cell class	SULF2 FCGR2B SIPA1L3 REL CSGALNACT1	2.46e-05	194	79	5	accf4b7b09e2048f2e47a52201e0158684dda8fe
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2-D032\|Children_(3_yrs) / Lineage, Cell type, age group and donor	HHIP PPP1R9A LRRK2 PRKD1 GLCCI1	2.46e-05	194	79	5	97534c8bba895a7913665e03ae4e5c4a6ad71daf
ToppCell	5'-Parenchyma_lung-Immune_Myeloid-Myeloid_monocytic-non-classical_monocyte-Non-classical_monocytes-Non-classical_monocytes_L.1.2.2.2\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	EAF1 DOCK8 REL LYST VSIR	2.46e-05	194	79	5	dfe0ece81922bfd7c6673726d3ea2365cbdb5513
ToppCell	distal-Hematologic-Nonclassical_Monocyte\|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	FCGR2C LINC00173 LRRK2 LYST VSIR	2.52e-05	195	79	5	6f417bb464b8ae6a50bbab5db5a6d5760c02122f
ToppCell	Adult-Immune-monocyte-D231\|Adult / Lineage, Cell type, age group and donor	SULF2 FCGR2B DOCK8 LYST VSIR	2.52e-05	195	79	5	ea24da6fea1487acb1e56c28c0649858cc0a12bd
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_1\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	TCF4 BRIP1 SULF2 FCGR2B SRD5A1	2.52e-05	195	79	5	2f2e29089a8cb748d2c1329c5c8465165b25bc8b
ToppCell	3'_v3-blood-Lymphocytic_NK-NK_CD56bright_CD16-\|blood / Manually curated celltypes from each tissue	IL12RB2 LMNA PPP1R9A NFKBIB REL	2.52e-05	195	79	5	1470f562ebcfe7da367964ecfd6c7f43bcdb4a73
ToppCell	BAL-Mild-Myeloid-cDC-cDC-cDC_1\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	TCF4 BRIP1 SULF2 FCGR2B SRD5A1	2.52e-05	195	79	5	c9469e2d31beb30ebb64b3f0a5239e23119fbaa5
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	SIPA1L3 PPP1R9A PRKD1 NR6A1 GLCCI1	2.59e-05	196	79	5	ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell	3'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.1.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	CDKL5 HHIP CDKL2 PPP1R9A LRRK2	2.59e-05	196	79	5	82b117be41f2e7d677a42d2a5198726eeccb16d0
ToppCell	COVID-19-Myeloid-Monocytes\|COVID-19 / group, cell type (main and fine annotations)	TAOK3 MEGF9 DOCK8 LRRK2 VSIR	2.59e-05	196	79	5	04d710267658ea5601ae2cfb4ed5acb8a29bd8a1
ToppCell	10x5'v1-week_17-19-Myeloid_neutrophil-granulo-neutrophil\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	FCGR2C MEGF9 LRRK2 LYST VSIR	2.59e-05	196	79	5	ad193b231ff2f7c72590fab79919c179d5d2f327
ToppCell	wk_20-22-Hematologic-Myeloid-S100A12-hi_cla._mono.\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	FCGR2C MEGF9 LRRK2 LYST VSIR	2.65e-05	197	79	5	e862561f61a1ae1ec858b34f8d9c9a7dc8894104
ToppCell	normal-na-Myeloid-classical_monocyte-male\|normal / PBMC cell types (v2) per disease, treatment status, and sex	FCGR2C MEGF9 LRRK2 LYST VSIR	2.72e-05	198	79	5	58aa5041077fe17ca01c5e6da077d8008d5123ab
ToppCell	10x5'v1-week_14-16-Myeloid_neutrophil-granulo-neutrophil-neutrophil\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	FCGR2C SULF2 MEGF9 LRRK2 VSIR	2.72e-05	198	79	5	e76061e66f6d60f5735962aa7777dda8958caed9
ToppCell	LPS_only-Hematopoietic_Myeloid-Dendritic_cells-mDC\|LPS_only / Treatment groups by lineage, cell group, cell type	TAOK3 SULF2 DOCK8 REL PDCD1LG2	2.72e-05	198	79	5	53c22e81e530d6fc272d4a45c8d1bf125feb254d
ToppCell	Parenchymal-NucSeq\|Parenchymal / Cell types per location group and 10X technology with lineage, and cell group designations	SIPA1L3 PPP1R9A PRKD1 NR6A1 GLCCI1	2.72e-05	198	79	5	1996373bdccc55aac347d349bd22f6aad6d0c668
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_alveolar-AT2\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	HHIP CDKL2 PPP1R9A LRRK2 PRKD1	2.72e-05	198	79	5	2e2a4e1756bba6f4fbe529559a97d2993c890b4b
ToppCell	Transverse-T_cell-Tcm\|T_cell / Region, Cell class and subclass	CRTC3 MED12L NR6A1 CSGALNACT1 UNC13A	2.72e-05	198	79	5	62990b9ff7ca20895fed07461baba6c2caaa995e
ToppCell	Parenchymal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CDKL5 SIPA1L3 PPP1R9A NR6A1 GLCCI1	2.78e-05	199	79	5	5cea0d9e261903e0eaad60c28a07dff72ce65027
ToppCell	healthy_donor-Myeloid-Monocytic\|healthy_donor / Disease condition, Lineage, Cell class and subclass	SULF2 MEGF9 LRRK2 LYST VSIR	2.78e-05	199	79	5	bd66a8d1a7cc92313328acc7c7ae0442faff951e
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_II\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	FCGR2C DOCK8 REL SYNDIG1 VSIR	2.78e-05	199	79	5	e7faf7d0cb43cf93149c446e5f718f84fa85477c
ToppCell	5'-Parenchyma_lung-Epithelial-Alveolar_epithelium-type_II_pneumocyte-AT2-AT2_L.0.1.3.1\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	HHIP MEGF9 CDKL2 PPP1R9A LRRK2	2.78e-05	199	79	5	2dc33804f6691d7c9682e6c9b885e945fb97fc36
ToppCell	COVID_vent-Myeloid\|COVID_vent / Disease condition, Lineage, Cell class and subclass	SULF2 MEGF9 LRRK2 LYST VSIR	2.85e-05	200	79	5	621af09aae34226902c03edf556562f3ab35a7d8
ToppCell	mild-HLA-DR+_CD83+_Monocyte\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SULF2 EAF1 MEGF9 LRRK2 LYST	2.85e-05	200	79	5	934c2efc780318c66d667ca75be0de350361d351
ToppCell	COVID_vent-Myeloid-Monocytic-CD14+_Monocyte\|COVID_vent / Disease condition, Lineage, Cell class and subclass	SULF2 MEGF9 LRRK2 LYST VSIR	2.85e-05	200	79	5	e57452b73abb21cb3f645d45523ab93f6bef0243
ToppCell	COVID_vent-Myeloid-Monocytic\|COVID_vent / Disease condition, Lineage, Cell class and subclass	SULF2 MEGF9 LRRK2 LYST VSIR	2.85e-05	200	79	5	b0a5bee87700ce38f26f95a6f491da7e27cade51
ToppCell	COVID_non-vent-Myeloid\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	SULF2 MEGF9 LRRK2 LYST VSIR	2.85e-05	200	79	5	a40768e8e58c86b8e20bc188b9274ebe412fc765
ToppCell	10x5'v1-week_14-16-Myeloid_monocytic-monocyte-CD14_monocyte\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	FCGR2C SULF2 MEGF9 LRRK2 VSIR	2.85e-05	200	79	5	f65837b51bce94c08125b1a2e1a696a15267f64b
ToppCell	COVID_non-vent-Myeloid-Monocytic\|COVID_non-vent / Disease condition, Lineage, Cell class and subclass	SULF2 MEGF9 LRRK2 LYST VSIR	2.85e-05	200	79	5	4243a9d32f3a11141284d0d944cb81194b532876
ToppCell	367C-Myeloid-Macrophage-SPP1+_Macrophage_2\|367C / Donor, Lineage, Cell class and subclass (all cells)	BRIP1 FCGR2B MUC16 REL	1.16e-04	141	79	4	e409da87da5a38ba4d0ccc5e3f8bd89f480f9dab
ToppCell	PND03-Immune-Immune_Myeloid-Granulocytic-Neutrophil-Neutrophil_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	BRCA1 RECQL4 SRD5A1 MED12L	1.58e-04	153	79	4	489228ab81c3ae339a53a9da6c2a1c1b6ac3f84b
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-IPC_like\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	TCF4 CD6 SYNDIG1 CSGALNACT1	1.71e-04	156	79	4	7e6805ebc7bc2f9c5965321d16922c155719970f
ToppCell	Brain_organoid-organoid_Kanton_Nature-Organoid-1M-IPC_like-IPs_and_early_cortical_neurons\|Organoid-1M / Sample Type, Dataset, Time_group, and Cell type.	TCF4 CD6 SYNDIG1 CSGALNACT1	1.71e-04	156	79	4	741de05295b2d012ac8576378f37709a97c8fb50
ToppCell	356C-Lymphocytic-CD8+_Cytotoxic_T-cell\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	SP6 MUC16 LYST PDCD1LG2	1.75e-04	157	79	4	f2bc60ec0305b056d79f1b7fd6b5e3730d606916
ToppCell	Children_(3_yrs)-Endothelial-endothelial_cell_of_artery-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	TCF4 SULF2 TMEM132A CSGALNACT1	1.75e-04	157	79	4	275a4c6fef1fff8da2bdc48e3924ad05c5e5cfc8
ToppCell	PND28-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_B-B-B_prolif\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	IL12RB2 BRIP1 SIPA1L3 MED12	1.75e-04	157	79	4	6730b775308f45a2f3946016bdbb7f8e5b5efe49
ToppCell	normal_Lymph_Node-B_lymphocytes-Undetermined\|normal_Lymph_Node / Location, Cell class and cell subclass	TCF4 DOCK8 REL KMT2E	1.97e-04	162	79	4	91ac35ae7fde411cd6a44e715a33dac62419cab8
ToppCell	facs-Marrow-Granulocytes-18m-Lymphocytic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	HHIP CD6 ADAMTS13 GLCCI1	2.02e-04	163	79	4	7a04192710f55acf5a4681d5f09942358fdb02ff
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L4\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	LRRK2 PLEKHA4 R3HDM1 GLCCI1	2.02e-04	163	79	4	1e8ab00ecc2d2ba35aa6745c0ed38663e26312e8
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L4-L4_IT_VISp_Rspo1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	LRRK2 PLEKHA4 R3HDM1 GLCCI1	2.02e-04	163	79	4	431221a41d396b09170476179590eaf8a55266d8
ToppCell	TCGA-Uterus-Primary_Tumor-Uterine_Carcinoma-Uterine_Carcinosarcoma-3\|TCGA-Uterus / Sample_Type by Project: Shred V9	MEGF9 DOCK8 LYST CSGALNACT1	2.02e-04	163	79	4	d64dd39b077105c73e570ccef70f0e74a2c586ac
ToppCell	343B-Epithelial_cells-Epithelial-A_(AT2)-\|343B / Donor, Lineage, Cell class and subclass (all cells)	CDKL5 HHIP CDKL2 LRRK2	2.07e-04	164	79	4	beaa13a75c3bb72446c85084d75e9fe3f15fd3d4
ToppCell	343B-Epithelial_cells-Epithelial-A_(AT2)\|343B / Donor, Lineage, Cell class and subclass (all cells)	CDKL5 HHIP CDKL2 LRRK2	2.07e-04	164	79	4	d005cfd821b87548b075120bffe65a0be9860463
ToppCell	droplet-Lung-nan-3m-Myeloid-Ccr7+_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BRCA1 TMEM132A MED12L EFR3B	2.07e-04	164	79	4	78de403446fe0eb375c82ff1832cc5fbb8e20afa
ToppCell	droplet-Lung-3m-Hematologic-myeloid-myeloid_dendritic_cell-Ccr7+_dendritic\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	BRCA1 TMEM132A MED12L REL	2.12e-04	165	79	4	c39f0479955c4e23921f7a450d3bc251a002200f
ToppCell	Dendritic_Cells-Donor_02\|World / lung cells shred on cell class, cell subclass, sample id	TCF4 FCGR2B CSGALNACT1 VSIR	2.16e-04	166	79	4	fbeb74b98b58085de323f744b18d4a8f7b22d5d4
ToppCell	Children_(3_yrs)-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D046\|Children_(3_yrs) / Lineage, Cell type, age group and donor	PPP1R9A LRRK2 NR6A1 GLCCI1	2.16e-04	166	79	4	c20479fe7a4306320d7f26e78bf956225f00f35a
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CDCA2 BRIP1 BRCA1 RECQL4	2.21e-04	167	79	4	50c29ea660bf07b890e4ac1a1985d0761d863dee
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Cycling_Endothelial_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CDCA2 TCF4 BRIP1 RECQL4	2.21e-04	167	79	4	bc132b51dec4e8f1cd2b2cd89f83641976e09292
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_B-Memory_B_cells\|GI_small-bowel / Manually curated celltypes from each tissue	TCF4 LINC00173 TMEM132A CSGALNACT1	2.27e-04	168	79	4	8e025bb0541746e232b77ac0e31412ae71420c47
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_G2M\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	CDCA2 BRIP1 BRCA1 RECQL4	2.27e-04	168	79	4	d35944fd9fea9934ce1e76b2b35d48e2300cca61
ToppCell	3'_v3-GI_small-bowel-Lymphocytic_B\|GI_small-bowel / Manually curated celltypes from each tissue	TCF4 LINC00173 TMEM132A CSGALNACT1	2.27e-04	168	79	4	5535c1b8b7fde7b59a1bc0580cebdfa963aa1c39
Drug	Fusidic acid sodium salt [751-94-0]; Up 200; 7.4uM; MCF7; HT_HG-U133A	TCF4 SMG7 ALMS1 LMNA MAMLD1 SYNDIG1 KLHL22	4.86e-06	198	77	7	2647_UP
Drug	Heptaminol hydrochloride [543-15-7]; Up 200; 22uM; PC3; HT_HG-U133A	LMNA RNF6 MEGF9 SIPA1L3 NPRL3 ADAMTS13 KLHL22	4.86e-06	198	77	7	7313_UP
Disease	response to glucocorticoid, osteonecrosis	BRIP1 PPP1R9A SP6 CSGALNACT1	3.46e-06	39	78	4	EFO_0004259, GO_0051384
Disease	Immune thrombocytopenic purpura	FCGR2C ADAMTS13	6.90e-06	2	78	2	C0398650
Disease	transmembrane protein 132A measurement	CD6 TMEM132A	4.12e-05	4	78	2	EFO_0802150
Disease	Hypospadias	HHIP MAMLD1	6.86e-05	5	78	2	C0848558
Disease	Neurodevelopmental Disorders	CDKL5 TCF4 DOCK8 KMT2E	1.10e-04	93	78	4	C1535926
Disease	free cholesterol:total lipids ratio, high density lipoprotein cholesterol measurement	SULF2 ATXN2 LPA SP6 NPRL3 CSGALNACT1	1.54e-04	303	78	6	EFO_0004612, EFO_0020945
Disease	birth weight, parental genotype effect measurement	FCGR2C HHIP CRTC3 FCGR2B ATXN2	1.59e-04	192	78	5	EFO_0004344, EFO_0005939
Disease	Anorectal Malformations	HHIP EAF1 MED12	1.76e-04	41	78	3	C3495676
Disease	total cholesterol measurement, high density lipoprotein cholesterol measurement	RMDN3 SULF2 ATXN2 LPA SP6 CSGALNACT1	1.90e-04	315	78	6	EFO_0004574, EFO_0004612
Disease	eosinophil measurement	ATXN2 SYNDIG1 GLCCI1 CSGALNACT1	1.97e-04	108	78	4	EFO_0803540
Disease	MENTAL RETARDATION, AUTOSOMAL DOMINANT 40	BRCA1 KMT2E	2.45e-04	9	78	2	C4225275
Disease	malaria (implicated_via_orthology)	FCGR2C FCGR2B	2.45e-04	9	78	2	DOID:12365 (implicated_via_orthology)
Disease	plexin-B2 measurement	FCGR2C FCGR2B	2.45e-04	9	78	2	EFO_0021867
Disease	systemic lupus erythematosus (is_marker_for)	LPA ADAMTS13 TAB3	2.65e-04	47	78	3	DOID:9074 (is_marker_for)
Disease	triglycerides:total lipids ratio, intermediate density lipoprotein measurement	ATXN2 LPA SP6 CSGALNACT1	3.65e-04	127	78	4	EFO_0008595, EFO_0020947
Disease	tyrosine-protein kinase receptor Tie-1, soluble measurement	NPRL3 ADAMTS13	5.28e-04	13	78	2	EFO_0008312
Disease	Hereditary Breast and Ovarian Cancer Syndrome	BRIP1 BRCA1	6.15e-04	14	78	2	C0677776
Disease	monocyte count	TCF4 FCGR2C LMNA FCGR2B ATXN2 DOCK8 LPA MED12L USF1 LYST VSIR	6.83e-04	1320	78	11	EFO_0005091
Disease	breast carcinoma (is_marker_for)	BRIP1 BRCA1 SRD5A1	7.21e-04	66	78	3	DOID:3459 (is_marker_for)
Disease	central nervous system disease (implicated_via_orthology)	TAOK3 SEC31A	8.08e-04	16	78	2	DOID:331 (implicated_via_orthology)
Disease	myeloid white cell count	TCF4 LMNA FCGR2B ATXN2 DOCK8 MED12L KMT2E GLCCI1 VSIR	8.11e-04	937	78	9	EFO_0007988
Disease	rheumatoid arthritis (is_marker_for)	LPA LRRK2 TAB3	8.21e-04	69	78	3	DOID:7148 (is_marker_for)
Disease	diabetic neuropathy (biomarker_via_orthology)	HHIP LRRK2	9.14e-04	17	78	2	DOID:9743 (biomarker_via_orthology)
Disease	low affinity immunoglobulin gamma Fc region receptor II-a measurement	FCGR2C FCGR2B	9.14e-04	17	78	2	EFO_0021969
Disease	phospholipids in large HDL measurement	SULF2 LPA SP6	9.67e-04	73	78	3	EFO_0022190
Disease	age at menarche	TCF4 SULF2 ALMS1 BRCA1 SP6 PRKD1 NR6A1	9.94e-04	594	78	7	EFO_0004703
Disease	total lipids in large HDL	SULF2 LPA SP6	1.01e-03	74	78	3	EFO_0022189
Disease	C-X-C motif chemokine 16 measurement	ATXN2 VSIR	1.03e-03	18	78	2	EFO_0010911
Disease	serum IgG measurement	FCGR2B UNC13A	1.03e-03	18	78	2	EFO_0004565
Disease	very low density lipoprotein cholesterol measurement, phospholipids:total lipids ratio	SULF2 ATXN2 LPA SP6 CSGALNACT1	1.06e-03	291	78	5	EFO_0008317, EFO_0020946
Disease	high density lipoprotein particle size measurement	SULF2 LPA SP6 CSGALNACT1	1.09e-03	170	78	4	EFO_0008592
Disease	neutrophil percentage of leukocytes	CRTC3 ATXN2 DOCK8 FNBP4 SEC31A GLCCI1 VSIR	1.16e-03	610	78	7	EFO_0007990
Disease	free cholesterol in large HDL measurement	SULF2 LPA SP6	1.22e-03	79	78	3	EFO_0022157
Disease	inflammatory bowel disease	IL12RB2 CRTC3 CD6 ATXN2 LRRK2 EPX	1.22e-03	449	78	6	EFO_0003767
Disease	maximal midexpiratory flow rate	BRIP1 MED12L	1.27e-03	20	78	2	EFO_0004313
Disease	phospholipids:total lipids ratio, high density lipoprotein cholesterol measurement	SULF2 ATXN2 LPA SP6 CSGALNACT1	1.34e-03	307	78	5	EFO_0004612, EFO_0020946
Disease	BREAST CANCER	BRIP1 BRCA1	1.40e-03	21	78	2	114480
Disease	cholesteryl ester measurement, high density lipoprotein cholesterol measurement	SULF2 ATXN2 LPA SP6 CSGALNACT1	1.44e-03	312	78	5	EFO_0004612, EFO_0010351
Disease	heart failure	BRIP1 ATXN2 LPA PRKD1	1.49e-03	185	78	4	EFO_0003144
Disease	free cholesterol measurement, high density lipoprotein cholesterol measurement	SULF2 ATXN2 LPA SP6 CSGALNACT1	1.50e-03	315	78	5	EFO_0004612, EFO_0008591
Disease	Parkinson disease	ATXN2 LRRK2	1.54e-03	22	78	2	cv:C0030567
Disease	lymphocyte count	TCF4 UBAP2 CD6 ALMS1 ATXN2 INSRR SP6 MED12L EPX LYST VSIR	1.58e-03	1464	78	11	EFO_0004587
Disease	Ovarian Serous Adenocarcinoma	CDKL5 LRRK2	1.68e-03	23	78	2	C1335177
Disease	Fanconi Anemia	BRIP1 BRCA1	1.99e-03	25	78	2	C0015625
Disease	low affinity immunoglobulin gamma Fc region receptor II-b measurement	FCGR2C FCGR2B	1.99e-03	25	78	2	EFO_0021970
Disease	neuroimaging measurement	TCF4 HHIP SULF2 UBAP2 BRCA1 ADAMTS3 ATXN2 GLCCI1 SLC4A9	2.02e-03	1069	78	9	EFO_0004346
Disease	hip circumference	CDCA2 TAOK3 DOCK8 SP6 PRKD1	2.04e-03	338	78	5	EFO_0005093
Disease	chylomicron measurement, very low density lipoprotein cholesterol measurement, lipid measurement	LPA SP6 CSGALNACT1	2.07e-03	95	78	3	EFO_0004529, EFO_0008317, EFO_0008596
Disease	serum alanine aminotransferase measurement	FCGR2C HHIP BRIP1 FCGR2B ATXN2 RECQL4 FNBP4 SP6	2.09e-03	869	78	8	EFO_0004735
Disease	chylomicron measurement, triglyceride measurement, very low density lipoprotein cholesterol measurement	LPA SP6 CSGALNACT1	2.13e-03	96	78	3	EFO_0004530, EFO_0008317, EFO_0008596
Disease	Acute monocytic leukemia	BRIP1 BRCA1	2.15e-03	26	78	2	C0023465
Disease	Malignant tumor of breast	BRIP1 BRCA1	2.32e-03	27	78	2	cv:C0006142
Disease	Breast neoplasm	BRIP1 BRCA1	2.32e-03	27	78	2	cv:C1458155
Disease	Familial cancer of breast	BRIP1 BRCA1	2.32e-03	27	78	2	cv:C0346153
Disease	wellbeing measurement	TCF4 TAOK3 ATXN2 SIPA1L3 LRRK2 FNBP4 PRKD1	2.37e-03	692	78	7	EFO_0007869
Disease	neutrophil count, eosinophil count	FCGR2B ATXN2 DOCK8 GLCCI1	2.48e-03	213	78	4	EFO_0004833, EFO_0004842
Disease	retinal vasculature measurement	CDCA2 TCF4 ATXN2 R3HDM1 GLCCI1 UNC13A	2.49e-03	517	78	6	EFO_0010554
Disease	obesity (implicated_via_orthology)	TCF4 ALMS1 MED12L MED12	2.57e-03	215	78	4	DOID:9970 (implicated_via_orthology)
Disease	cholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement	ATXN2 LPA CSGALNACT1	2.60e-03	103	78	3	EFO_0008595, EFO_0020944

Protein segments in the cluster

Peptide	Gene	Start	Entry
TSQPNASVHQYSVRP	UNC13A	216	Q9UPW8
LQRPQHYNQTTGTRP	SLC4A9	176	Q96Q91
YQLTTRPVTDGQPHS	CNTNAP1	1131	P78357
LNSPAENSPNHRPYT	CSGALNACT1	191	Q8TDX6
HNGNLIPTHTQPSYR	FCGR2B	86	P31994
LPSNSYPQREHSVIS	ALMS1	1846	Q8TCU4
RSPDSLHYISPNGVN	CPNE3	306	O75131
ATVPYQLLRGSQHSP	GLCCI1	66	Q86VQ1
HQQPYNSRPAVANGT	EAF1	226	Q96JC9
VTPNLTSVYIANHRP	ADAMTS13	576	Q76LX8
SLPQGSQGIPHQTYQ	R3HDM1	736	Q15032
PANTSHSRTPEGLYQ	PDCD1LG2	161	Q9BQ51
SLGPQYHPRSNSESS	CD6	551	P30203
SSYTVPNSRQDLHPL	OTOA	21	Q7RTW8
LSQQTHGITRLGPYS	MUC16	14016	Q8WXI7
QGLQYPTHLINPSAS	PRKD1	876	Q15139
YLLGNSSPRTQSPQN	LMNA	646	P02545
SPYLQPLTGSQRLNH	MED12L	2001	Q86YW9
SQPLYRSSLSHLGPQ	DTX2	276	Q86UW9
SPQQQSAIYHAGLAP	ATXN2	1186	Q99700
SSPNYEGPLHSLQSR	TCF4	371	P15884
YRVSQNSHPINSLQP	IL12RB2	576	Q99665
NSHPINSLQPRVTYV	IL12RB2	581	Q99665
SHIPGTPNQISENYS	CSRNP3	441	Q8WYN3
YLAQGPDRTPDTNHT	NFKBIB	161	Q15653
HNGNLIPTHTQPSYR	FCGR2C	86	P31995
SQYRASAPNSHVPLS	EPX	486	P11678
TITAAYGQPQNHSIP	EFR3B	791	Q9Y2G0
YPFQRSQEHPASQTS	NPRL3	26	Q12980
SQQLGSPYRPHHSQS	KMT2E	1471	Q8IZD2
SPNLQRHSNSLGPIF	LRRK2	926	Q5S007
APNGQLTLTTPIHNY	MEGF9	586	Q9H1U4
QQAPTYGHGLTSTQR	MED12	2001	Q93074
HQQYSSLQSSPIPIA	PHC3	486	Q8NDX5
NQGTSRHFNYPSTPP	BRIP1	101	Q9BX63
AVLEQHGSQPSNSYP	BRCA1	1416	P38398
SQHSYPLNRFSSVPL	CBY2	86	Q8NA61
QPQTYQSHFRSPSLA	CCNYL3	311	P0C7X3
PNRHSPSGIYNINVT	CDKL2	456	Q92772
TDPINNHQPGSATYR	ADAMTS3	121	O15072
YHRNESLQPSLQSPQ	KLHL22	276	Q53GT1
PPNLGQYHRQSISTS	DOCK8	31	Q8NF50
TQYHGGSLPNVSQLR	CRTC3	56	Q6UUV7
HSRTPENYPNAGLTR	LPA	1086	P08519
HAPNLSNGVSSQKYP	LYST	1401	Q99698
PTTSRQPSLLHYLQQ	MAMLD1	561	Q13495
SPHQGAQSPIVYLRT	INSRR	586	P14616
SPSQGSPALYRNVNT	CDCA2	126	Q69YH5
QSSQYSDPKSHGNRP	KATNA1	116	O75449
LGYTSPFSSQQRPHR	CDKL5	596	O76039
PSISGAPHLNSYQSL	PRR23D1	51	E9PI22
SYSGHSPLLPQQARS	NR6A1	231	Q15406
YTNTSPPNLSTGRQR	RUSC2	481	Q8N2Y8
PTSPSYRGQHILANS	HSF5	401	Q4G112
HGRSQSLPNSLDYTQ	RMDN3	41	Q96TC7
VQQVGHYPPANSSLS	TMEM132A	61	Q24JP5
PQYQSHRVGASTVPA	SYNDIG1	46	Q9H7V2
PISNQPSPRNQHSLY	TAB3	386	Q8N5C8
TQVQGLQHYQPSSVP	FNBP4	251	Q8N3X1
PRTQAHSGSPTYLQL	PLEKHA4	321	Q9H4M7
NPRYHGLSPSSQARA	RECQL4	316	O94761
GKQSHIPYSQQRPSG	SMG7	711	Q92540
SRSPIQRQSGTVYHN	RNF6	311	Q9Y252
FHVSTLLPYTPNNRQ	SIPA1L3	696	O60292
PRPTQSVQSQALHYR	TAOK3	416	Q9H2K8
LQPLQTYQGHTSPEA	SP6	26	Q3SY56
YSIPRSNPHFNSTNQ	HHIP	406	Q96QV1
PSISGAPHLNSYQSL	PRR23D2	51	P0DMB1
PSQPLSRQHGTYRQI	TUBA4B	11	Q9H853
GPYLRSLSQHPATQT	LINC00173	81	Q6ZV60
SVHNRIPYQSPVSSS	UBAP2	621	Q5T6F2
TNYASHSPPVNRALT	STAMBPL1	236	Q96FJ0
HPLSYVAQRQPSESG	VSIR	261	Q9H7M9
PGEHSTDNNRTYPSI	REL	36	Q04864
NRQTNSVYGRHALPS	SRD5A1	31	P18405
VENHGYFLNPSRSSP	UBE4A	346	Q14139
PAQNHPIYLATGTSA	SEC31A	16	O94979
SRLFPNASQHITPSY	SULF2	236	Q8IWU5
SNTQPLTQYFISGRH	USP6	551	P35125
QGGSQRSIAPRTHPY	USF1	171	P22415
TGHYPLNLPSVTVTN	PPP1R9A	231	Q9ULJ8