Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	ATP-dependent activity	MSH6 ACSM4 MYO1A HSPA4L ZGRF1 NAV2 ABCB11 SLFN11 ASCC3 FANCM DNAH6 ABCA10 ABCA8 DHX30	1.59e-07	614	81	14	GO:0140657
GeneOntologyMolecularFunction	DNA helicase activity	ZGRF1 NAV2 ASCC3 FANCM DHX30	5.23e-06	62	81	5	GO:0003678
GeneOntologyMolecularFunction	ATP-dependent activity, acting on DNA	MSH6 ZGRF1 NAV2 ASCC3 FANCM DHX30	1.29e-05	127	81	6	GO:0008094
GeneOntologyMolecularFunction	3'-5' DNA helicase activity	NAV2 ASCC3 FANCM	3.47e-05	16	81	3	GO:0043138
GeneOntologyMolecularFunction	helicase activity	ZGRF1 NAV2 SLFN11 ASCC3 FANCM DHX30	4.44e-05	158	81	6	GO:0004386
GeneOntologyMolecularFunction	ATP hydrolysis activity	NAV2 ABCB11 SLFN11 ASCC3 FANCM DNAH6 ABCA10 ABCA8 DHX30	7.36e-05	441	81	9	GO:0016887
GeneOntologyMolecularFunction	ribonucleoside triphosphate phosphatase activity	RALA RASA1 NAV2 ABCB11 SLFN11 ASCC3 FANCM DNAH6 ABCA10 ABCA8 DHX30	2.86e-04	775	81	11	GO:0017111
GeneOntologyMolecularFunction	pyrophosphatase activity	RALA RASA1 NAV2 ABCB11 SLFN11 ASCC3 FANCM DNAH6 ABCA10 ABCA8 DHX30	5.58e-04	839	81	11	GO:0016462
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides	RALA RASA1 NAV2 ABCB11 SLFN11 ASCC3 FANCM DNAH6 ABCA10 ABCA8 DHX30	5.63e-04	840	81	11	GO:0016817
GeneOntologyMolecularFunction	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	RALA RASA1 NAV2 ABCB11 SLFN11 ASCC3 FANCM DNAH6 ABCA10 ABCA8 DHX30	5.63e-04	840	81	11	GO:0016818
GeneOntologyMolecularFunction	catalytic activity, acting on DNA	MSH6 ZGRF1 NAV2 ASCC3 FANCM DHX30	6.87e-04	262	81	6	GO:0140097
GeneOntologyMolecularFunction	ABC-type transporter activity	ABCB11 ABCA10 ABCA8	1.04e-03	49	81	3	GO:0140359
GeneOntologyMolecularFunction	cAMP-dependent protein kinase regulator activity	PRKAR1A NOS2	1.23e-03	13	81	2	GO:0008603
GeneOntologyMolecularFunction	ABC-type xenobiotic transporter activity	ABCB11 ABCA8	1.65e-03	15	81	2	GO:0008559
GeneOntologyMolecularFunction	calcium-dependent phospholipid binding	SYT12 ANXA4 C2CD5	1.86e-03	60	81	3	GO:0005544
GeneOntologyBiologicalProcess	DNA duplex unwinding	ZGRF1 NAV2 ASCC3 FANCM DHX30	1.16e-05	78	78	5	GO:0032508
GeneOntologyBiologicalProcess	DNA geometric change	ZGRF1 NAV2 ASCC3 FANCM DHX30	1.86e-05	86	78	5	GO:0032392
GeneOntologyBiologicalProcess	DNA conformation change	ZGRF1 NAV2 ASCC3 FANCM DHX30	2.87e-05	94	78	5	GO:0071103
GeneOntologyBiologicalProcess	actin cytoskeleton organization	RALA FLNB CDC42BPA MYO1A RASA1 XIRP2 MTOR PRKAR1A ACTN2 HAX1 ERMN NCKAP1L	4.57e-05	803	78	12	GO:0030036
Domain	P-loop_NTPase	RALA MSH6 LRRIQ1 MYO1A ZGRF1 NAV2 ABCB11 SLFN11 LRRK1 ASCC3 FANCM DNAH6 ABCA10 ABCA8 DHX30	1.91e-06	848	78	15	IPR027417
Domain	-	RALA MSH6 ZGRF1 NAV2 ABCB11 SLFN11 LRRK1 ASCC3 FANCM DNAH6 ABCA10 ABCA8 DHX30	1.19e-05	746	78	13	3.40.50.300
Domain	AAA+_ATPase	NAV2 ABCB11 ASCC3 DNAH6 ABCA10 ABCA8	3.08e-05	144	78	6	IPR003593
Domain	AAA	NAV2 ABCB11 ASCC3 DNAH6 ABCA10 ABCA8	3.08e-05	144	78	6	SM00382
Domain	ABC_tran	ABCB11 ABCA10 ABCA8	1.06e-03	48	78	3	PF00005
Domain	ABC_TRANSPORTER_2	ABCB11 ABCA10 ABCA8	1.06e-03	48	78	3	PS50893
Domain	ABC_A	ABCA10 ABCA8	1.11e-03	12	78	2	IPR026082
Domain	ABC_TRANSPORTER_1	ABCB11 ABCA10 ABCA8	1.12e-03	49	78	3	PS00211
Domain	ABC_transporter-like	ABCB11 ABCA10 ABCA8	1.19e-03	50	78	3	IPR003439
Domain	CH	FLNB NAV2 ACTN2	2.54e-03	65	78	3	SM00033
Domain	Synaptotagmin	SYT12 C2CD5	3.12e-03	20	78	2	IPR001565
Domain	His_PPase_superfam	ACP2 UBASH3A	3.12e-03	20	78	2	IPR029033
Domain	-	ACP2 UBASH3A	3.12e-03	20	78	2	3.40.50.1240
Domain	CH	FLNB NAV2 ACTN2	3.14e-03	70	78	3	PF00307
Domain	-	FLNB NAV2 ACTN2	3.27e-03	71	78	3	1.10.418.10
Domain	-	RASA1 SYT12 ASCC3 C2CD5	3.43e-03	148	78	4	2.60.40.150
Domain	DEAD/DEAH_box_helicase_dom	ASCC3 FANCM DHX30	3.53e-03	73	78	3	IPR011545
Domain	CH	FLNB NAV2 ACTN2	3.53e-03	73	78	3	PS50021
Domain	DEAD	ASCC3 FANCM DHX30	3.53e-03	73	78	3	PF00270
Domain	CH-domain	FLNB NAV2 ACTN2	3.81e-03	75	78	3	IPR001715
Domain	Actinin_actin-bd_CS	FLNB ACTN2	4.12e-03	23	78	2	IPR001589
Domain	ACTININ_2	FLNB ACTN2	4.12e-03	23	78	2	PS00020
Domain	ACTININ_1	FLNB ACTN2	4.12e-03	23	78	2	PS00019
Domain	C2_dom	RASA1 SYT12 ASCC3 C2CD5	4.94e-03	164	78	4	IPR000008
Pubmed	KCTD13-mediated ubiquitination and degradation of GluN1 regulates excitatory synaptic transmission and seizure susceptibility.	RALA FLNB MAP1B NRXN2 SACS HSPA4L DOCK8 PRKAR1A NCAM2 ACTN2 HAX1 DNAH6 TRIP11 PCM1 DHX30 ERMN	1.67e-07	1431	81	16	37142655
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	RALA FLNB STX3 CDC42BPA EPHA6 PTPRG RASA1 MAP1B HEBP2 ANXA4 WDR70 U2AF2 NCAM2 SESN1 PCM1	1.58e-06	1489	81	15	28611215
Pubmed	∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.	FLNB TBC1D9B MYO1A MAP1B HSPA4L MTOR COPG2 ACTN2 HAX1 TNPO3	2.66e-06	647	81	10	26618866
Pubmed	Rapamycin attenuates endothelial apoptosis induced by low shear stress via mTOR and sestrin1 related redox regulation.	MTOR SESN1	5.36e-06	2	81	2	24587596
Pubmed	Depletion of type IA regulatory subunit (RIalpha) of protein kinase A (PKA) in mammalian cells and tissues activates mTOR and causes autophagic deficiency.	MTOR PRKAR1A	5.36e-06	2	81	2	16963469
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	MSH6 FLNB CDC42BPA MTOR ASCC3 DHX30	8.05e-06	202	81	6	33005030
Pubmed	Comparative interactome analysis of α-arrestin families in human and Drosophila.	TBC1D9B GET4 MAP1B PRKAR1A U2AF2 C2CD5 DHX30	8.80e-06	313	81	7	38270169
Pubmed	Functional proteomics mapping of a human signaling pathway.	RALA FLNB DOCK8 EXPH5 PRKAR1A U2AF2 ASCC3 TNPO3 DHX30	9.78e-06	591	81	9	15231748
Pubmed	An integrated genetic map of the pearl locus of mouse chromosome 13.	RASA1 MAP1B DHFR2	1.15e-05	19	81	3	8828042
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	MSH6 FLNB GET4 HSPA4L MTOR WDR70 HAX1 ASCC3 TNPO3 PCM1 C2CD5	1.59e-05	974	81	11	28675297
Pubmed	Genome-wide association study identifies genes that may contribute to risk for developing heroin addiction.	XIRP2 STYXL2	1.60e-05	3	81	2	20520587
Pubmed	[B7-H4-mediated immunoresistance is supressed by PI3K/Akt/mTOR pathway inhibitors].	MTOR VTCN1	1.60e-05	3	81	2	28064317
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	FLNB CDC42BPA ZGRF1 U2AF2 TNPO3 DHX30	1.85e-05	234	81	6	36243803
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	TBC1D9B TRPM3 SACS KDM4C EXPH5 FANCM ABCA8 C2CD5	2.00e-05	493	81	8	15368895
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	MSH6 FLNB MAP1B MTOR U2AF2 COPG2 ASCC3 PCM1 DHX30	2.15e-05	653	81	9	22586326
Pubmed	Mitochondrial antiviral-signalling protein is a client of the BAG6 protein quality control complex.	GET4 HSPA4L U2AF2	2.38e-05	24	81	3	35543156
Pubmed	CCR5-Dependent Activation of mTORC1 Regulates Translation of Inducible NO Synthase and COX-2 during Encephalomyocarditis Virus Infection.	MTOR NOS2	3.20e-05	4	81	2	26408666
Pubmed	Follicular thyroid cancers demonstrate dual activation of PKA and mTOR as modeled by thyroid-specific deletion of Prkar1a and Pten in mice.	MTOR PRKAR1A	3.20e-05	4	81	2	24512487
Pubmed	Inhibition of the Gab2/PI3K/mTOR signaling ameliorates myeloid malignancy caused by Ptpn11 (Shp2) gain-of-function mutations.	MTOR GAB4	3.20e-05	4	81	2	27840422
Pubmed	Identification of a novel protein complex containing annexin VI, Fyn, Pyk2, and the p120(GAP) C2 domain.	RASA1 ANXA4	3.20e-05	4	81	2	10708762
Pubmed	RalA functions as an indispensable signal mediator for the nutrient-sensing system.	RALA MTOR	3.20e-05	4	81	2	18948269
Pubmed	HEM1 deficiency disrupts mTORC2 and F-actin control in inherited immunodysregulatory disease.	MTOR NCKAP1L	3.20e-05	4	81	2	32647003
Pubmed	The proximal signaling network of the BCR-ABL1 oncogene shows a modular organization.	RASA1 GAB4 LRRK1 NCKAP1L	3.96e-05	81	81	4	20697350
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	MYT1L GPRASP1 FLNB SACS KDM4C PRKAR1A NCAM2 UBASH3A TRIP11 PCM1 DHX30 BRWD1	4.13e-05	1285	81	12	35914814
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	CDC42BPA MAP1B HSPA4L MED16 STK17B NKAPD1 PRKAR1A HAX1 UBASH3A C2CD5	5.02e-05	910	81	10	36736316
Pubmed	Ultrasound induces hypoxia-inducible factor-1 activation and inducible nitric-oxide synthase expression through the integrin/integrin-linked kinase/Akt/mammalian target of rapamycin pathway in osteoblasts.	MTOR NOS2	5.33e-05	5	81	2	17588951
Pubmed	Identification of HAX-1 as a protein that binds bile salt export protein and regulates its abundance in the apical membrane of Madin-Darby canine kidney cells.	ABCB11 HAX1	5.33e-05	5	81	2	15159385
Pubmed	The Ca2+-dependent lipid binding domain of P120GAP mediates protein-protein interactions with Ca2+-dependent membrane-binding proteins. Evidence for a direct interaction between annexin VI and P120GAP.	RASA1 ANXA4	5.33e-05	5	81	2	8798684
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	MSH6 U2AF2 SLFN11 HAX1 ASCC3 ABCA8 P3H4 PCM1 SLC4A11 C2CD5 BRWD1	5.50e-05	1116	81	11	31753913
Pubmed	Virus-Host Interactome and Proteomic Survey Reveal Potential Virulence Factors Influencing SARS-CoV-2 Pathogenesis.	MSH6 HSPA4L ABCB11 ACTN2 ASCC3 PCM1	5.57e-05	285	81	6	32838362
Pubmed	Tumor suppressor BAP1 nuclear import is governed by transportin-1.	MSH6 FLNB LRRIQ1 MAP1B HSPA4L HEBP2 PRKAR1A U2AF2 COPG2 SLFN11 ASCC3	7.13e-05	1149	81	11	35446349
Pubmed	The thrombospondin-4 gene.	RASA1 DHFR2	7.99e-05	6	81	2	10501972
Pubmed	Reassessment of the role of FKBP38 in the Rheb/mTORC1 pathway.	RALA MTOR	7.99e-05	6	81	2	19222999
Pubmed	Cloning and structure of the human corticotrophin releasing factor-binding protein gene (CRHBP).	RASA1 DHFR2	1.12e-04	7	81	2	8198617
Pubmed	A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.	MSH6 FLNB TBC1D9B STX3 MAP1B HSPA4L MTOR COPG2 HAX1 ASCC3 TNPO3 PCM1	1.22e-04	1440	81	12	30833792
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	RALA FLNB STX3 MYO1A MAP1B SACS HSPA4L NAV2 U2AF2 ACTN2 DNAH6 SLC4A11	1.24e-04	1442	81	12	35575683
Pubmed	Large-scale proteomics and phosphoproteomics of urinary exosomes.	RALA FLNB STX3 CDC42BPA HEBP2 ANXA4 ACP2 ABCB11 CUBN ERMN	1.25e-04	1016	81	10	19056867
Pubmed	Probing cellular protein complexes using single-molecule pull-down.	MTOR PRKAR1A	1.49e-04	8	81	2	21614075
Pubmed	Genetic Associations with Plasma B12, B6, and Folate Levels in an Ischemic Stroke Population from the Vitamin Intervention for Stroke Prevention (VISP) Trial.	MYT1L CUBN	1.49e-04	8	81	2	25147783
Pubmed	SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis.	MSH6 GET4 MAP1B MTOR PRKAR1A COPG2 HAX1 TNPO3	1.49e-04	657	81	8	36180527
Pubmed	A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum.	EPHA6 U2AF2 NCAM2	1.50e-04	44	81	3	32492419
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	FLNB CDC42BPA XIRP2 HEBP2 PRKAR1A ACTN2 TRIP11	1.63e-04	497	81	7	23414517
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	MAP1B SACS HSPA4L NCAM2 PCM1 C2CD5	1.63e-04	347	81	6	17114649
Pubmed	Charting the landscape of tandem BRCT domain-mediated protein interactions.	FLNB HSPA4L MTOR U2AF2 COPG2 SLFN11 CUBN FANCM	1.70e-04	670	81	8	22990118
Pubmed	Interaction of LATS1 with SMAC links the MST2/Hippo pathway with apoptosis in an IAP-dependent manner.	MAP1B XIRP2 PRKAR1A HAX1 ASCC3	1.75e-04	222	81	5	35941108
Pubmed	The mouse region syntenic for human spinal muscular atrophy lies within the Lgn1 critical interval and contains multiple copies of Naip exon 5.	MAP1B DHFR2	1.91e-04	9	81	2	8975718
Pubmed	Identification of WNT/beta-CATENIN signaling pathway components in human cumulus cells.	CTNNBIP1 FZD2	1.91e-04	9	81	2	19038973
Pubmed	MECP2 directly interacts with RNA polymerase II to modulate transcription in human neurons.	MSH6 CDC42BPA MAP1B NRXN2 SACS MED16 U2AF2 HAX1 DHX30 ALPG	2.07e-04	1082	81	10	38697112
Pubmed	Quantitative interactome proteomics identifies a proteostasis network for GABAA receptors.	MSH6 COPG2 HAX1 PCM1	2.14e-04	125	81	4	36030824
Pubmed	Vti1b promotes TRPV1 sensitization during inflammatory pain.	RALA FLNB U2AF2 ACTN2	2.27e-04	127	81	4	30335684
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	MSH6 MAP1B MTOR U2AF2 COPG2 HAX1 ASCC3 DHX30	2.38e-04	704	81	8	29955894
Pubmed	Comparative mapping in the beige-satin region of mouse chromosome 13.	RALA ACTN2	2.38e-04	10	81	2	9027500
Pubmed	High-resolution linkage map of mouse chromosome 13 in the vicinity of the host resistance locus Lgn1.	MAP1B DHFR2	2.38e-04	10	81	2	9119362
Pubmed	A molecular genetic linkage map of mouse chromosome 13 anchored by the beige (bg) and satin (sa) loci.	RALA DHFR2	2.38e-04	10	81	2	2307475
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	LRRC8E TBC1D9B GET4 CDC42BPA MTOR WDR70 NAV2 LRRK1 TNPO3 DHX30	2.45e-04	1105	81	10	35748872
Pubmed	Nuclear export factor family protein participates in cytoplasmic mRNA trafficking.	MAP1B U2AF2	2.91e-04	11	81	2	16014633
Pubmed	Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.	CTCFL SACS	2.91e-04	11	81	2	23300278
Pubmed	The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation.	GET4 MAP1B HSPA4L SLFN11 DHX30	3.20e-04	253	81	5	29911972
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	MSH6 MAP1B WDR70 COPG2 SLFN11 TRIP11 PCM1 DHX30 NOL8	3.24e-04	934	81	9	33916271
Pubmed	Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites.	MAP1B PCM1	3.48e-04	12	81	2	24089205
Pubmed	The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.	SACS MTOR ANXA4 WDR70 U2AF2 TNPO3	3.50e-04	400	81	6	35013556
Pubmed	Common genetic variation in multiple metabolic pathways influences susceptibility to low HDL-cholesterol and coronary heart disease.	TRPM3 ABCB11 CUBN	3.60e-04	59	81	3	20855565
Pubmed	The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2.	RALA STX3 CDC42BPA PTPRG MTOR EXPH5 NAV2	3.70e-04	569	81	7	30639242
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	RALA MTOR PRKAR1A COPG2 ASCC3 TNPO3 PCM1 NOL8	3.76e-04	754	81	8	33060197
Pubmed	ISG15 Connects Autophagy and IFN-γ-Dependent Control of Toxoplasma gondii Infection in Human Cells.	FLNB U2AF2 ASCC3 PCM1 DHX30	4.16e-04	268	81	5	33024031
Pubmed	Genome-wide CRISPR-cas9 knockout screening identifies GRB7 as a driver for MEK inhibitor resistance in KRAS mutant colon cancer.	MSH6 MTOR TNPO3	4.37e-04	63	81	3	34718347
Pubmed	Regional localization of three convertases, PC1 (Nec-1), PC2 (Nec-2), and furin (Fur), on mouse chromosomes.	RASA1 DHFR2	4.79e-04	14	81	2	1354647
Pubmed	Enoyl-CoA hydratase-1 regulates mTOR signaling and apoptosis by sensing nutrients.	MTOR BRWD1	4.79e-04	14	81	2	28878358
Pubmed	Neuropathy-causing mutations in HSPB1 impair autophagy by disturbing the formation of SQSTM1/p62 bodies.	MSH6 MAP1B HAX1	5.24e-04	67	81	3	30669930
Pubmed	Possible roles of Robo1+ ensheathing cells in guiding dorsal-zone olfactory sensory neurons in mouse.	ACSM4 NCAM2	5.52e-04	15	81	2	23821580
Pubmed	Reciprocal interaction between SIRT6 and APC/C regulates genomic stability.	MSH6 HSPA4L MED16 ASCC3 C2CD5 DHX30	5.78e-04	440	81	6	34244565
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	RALA FLNB MAP1B SACS PRKAR1A U2AF2 ASCC3 PCM1 DHX30	6.28e-04	1024	81	9	24711643
Pubmed	Molecular Characterization of the Oncogene BTF3 and Its Targets in Colorectal Cancer.	FLNB GET4 MAP1B U2AF2 COPG2 PCM1 DHX30	6.51e-04	626	81	7	33644029
Pubmed	R2TP/Prefoldin-like component RUVBL1/RUVBL2 directly interacts with ZNHIT2 to regulate assembly of U5 small nuclear ribonucleoprotein.	CDC42BPA MAP1B U2AF2 PCM1 DHX30	6.93e-04	300	81	5	28561026
Pubmed	A protein interaction landscape of breast cancer.	MSH6 HSPA4L NAV2 TRIP11 TNPO3 PCM1 DHX30	7.01e-04	634	81	7	34591612
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	FLNB HSPA4L MTOR COPG2 ASCC3 TNPO3 DHX30	7.28e-04	638	81	7	33239621
Pubmed	Large-scale mapping of human protein-protein interactions by mass spectrometry.	MSH6 GET4 CTNNBIP1 HSPA4L PRKAR1A U2AF2 COPG2 LRRK1 TNPO3 C2CD5	7.91e-04	1284	81	10	17353931
Pubmed	Identification of FMRP target mRNAs in the developmental brain: FMRP might coordinate Ras/MAPK, Wnt/β-catenin, and mTOR signaling during corticogenesis.	MYT1L MTOR	8.00e-04	18	81	2	33323119
Pubmed	HNF4 factors control chromatin accessibility and are redundantly required for maturation of the fetal intestine.	CUBN ALPG	8.93e-04	19	81	2	31345929
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CDC42BPA MAP1B MTOR EXPH5 NAV2 TRIP11 TNPO3 PCM1	8.94e-04	861	81	8	36931259
Pubmed	Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.	FLNB PRKAR1A U2AF2 COPG2 ACTN2 TNPO3 PCM1	9.27e-04	665	81	7	30457570
Pubmed	Proteomic analysis of steady-state nuclear hormone receptor coactivator complexes.	MSH6 U2AF2 TRIP11	1.05e-03	85	81	3	16051665
Pubmed	OTUB2 stabilizes U2AF2 to promote the Warburg effect and tumorigenesis via the AKT/mTOR signaling pathway in non-small cell lung cancer.	MTOR U2AF2	1.09e-03	21	81	2	30662561
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	MSH6 FLNB MAP1B SACS HSPA4L TNPO3	1.10e-03	498	81	6	36634849
Pubmed	Agrin has a pathological role in the progression of oral cancer.	FLNB SYT12 MAP1B ACTN2	1.18e-03	197	81	4	29872149
Pubmed	Regulation of Hematopoiesis and Methionine Homeostasis by mTORC1 Inhibitor NPRL2.	MTOR DHFR2	1.20e-03	22	81	2	26166573
Pubmed	LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.	FLNB MAP1B HSPA4L U2AF2 NCKAP1L	1.27e-03	344	81	5	30333137
Pubmed	An expanded Oct4 interaction network: implications for stem cell biology, development, and disease.	MSH6 CUBN BRWD1	1.28e-03	91	81	3	20362542
Pubmed	mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR.	MTOR FANCM	1.31e-03	23	81	2	22017875
Pubmed	Identification of 18 mouse ABC genes and characterization of the ABC superfamily in Mus musculus.	ABCB11 ABCA8	1.31e-03	23	81	2	10708515
Pubmed	BioID-based intact cell interactome of the Kv1.3 potassium channel identifies a Kv1.3-STAT3-p53 cellular signaling pathway.	RALA FLNB CDC42BPA MAP1B HSPA4L COPG2 ASCC3	1.33e-03	708	81	7	39231216
Pubmed	ABCE1 is a highly conserved RNA silencing suppressor.	RALA FLNB MAP1B HAX1	1.34e-03	204	81	4	25659154
Pubmed	The functional interactome of PYHIN immune regulators reveals IFIX is a sensor of viral DNA.	MSH6 MAP1B HSPA4L DHX30 NOL8	1.36e-03	349	81	5	25665578
Pubmed	A Large-scale genetic association study of esophageal adenocarcinoma risk.	MSH6 MTOR ABCB11 ASCC3 NOS2	1.39e-03	351	81	5	20453000
Pubmed	Loss of connectin novex-3 leads to heart dysfunction associated with impaired cardiomyocyte proliferation and abnormal nuclear mechanics.	ACTN2 PCM1	1.55e-03	25	81	2	38877142
Pubmed	A chemical tool for blue light-inducible proximity photo-crosslinking in live cells.	MTOR DHX30	1.55e-03	25	81	2	35211260
Pubmed	Host E3 ligase HUWE1 attenuates the proapoptotic activity of the MERS-CoV accessory protein ORF3 by promoting its ubiquitin-dependent degradation.	MSH6 FLNB GET4 COPG2 HAX1 DHX30	1.56e-03	534	81	6	35032548
Pubmed	The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors.	STK17B PRKAR1A TRIP11	1.63e-03	99	81	3	19730683
Pubmed	DDB1 binds histone reader BRWD3 to activate the transcriptional cascade in adipogenesis and promote onset of obesity.	MED16 WDR70 BRWD1	1.63e-03	99	81	3	34161765
Pubmed	Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.	FLNB MAP1B MTOR U2AF2	1.63e-03	215	81	4	35973513
Interaction	DNAJC7 interactions	GET4 CDC42BPA SACS HSPA4L MED16 DHFR2 U2AF2 HAX1 ASCC3 NOS2 C2CD5	9.15e-07	425	80	11	int:DNAJC7
Interaction	TACSTD2 interactions	TBC1D9B SACS MED16 MTOR STK17B TNPO3	1.25e-05	129	80	6	int:TACSTD2
Interaction	KCTD13 interactions	GPRASP1 RALA FLNB MAP1B NRXN2 SACS HSPA4L DOCK8 PRKAR1A NCAM2 ACTN2 HAX1 DNAH6 TRIP11 PCM1 DHX30 ERMN	2.69e-05	1394	80	17	int:KCTD13
Cytoband	17q24	ABCA10 ABCA8	1.37e-04	10	81	2	17q24
GeneFamily	X-linked mental retardation\|RNA helicases	ASCC3 FANCM	4.39e-04	11	52	2	1168
GeneFamily	ATP binding cassette subfamily A	ABCA10 ABCA8	7.22e-04	14	52	2	805
Coexpression	MURARO_PANCREAS_BETA_CELL	GPRASP1 TBC1D9B STX3 CDC42BPA MAP1B HSPA4L EXPH5 NAV2 HAX1 TRIP11 SESN1 PCM1 C2CD5	6.28e-06	946	81	13	M39169
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Calb2-Excitatory_Neuron.Slc17a7.Calb2-Adcyap1_(Dentate_hilum?)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CTCFL EXPH5 CUBN UBASH3A ALPG	1.48e-07	67	81	5	52f6c244e8d89ccacb79bc5ef3663a5d01fd393c
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Calb2-Excitatory_Neuron.Slc17a7.Calb2-Adcyap1_(Dentate_hilum?)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	CTCFL EXPH5 CUBN UBASH3A ALPG	1.48e-07	67	81	5	e462f9b5dca7c64101a31891f25654c05f2d215d
ToppCell	RA-01._Fibroblast_I\|RA / Chamber and Cluster_Paper	GET4 PTPRG NAV2 NCAM2 ABCA8	1.43e-05	169	81	5	6373562ab3b1765060212a6a53d6543e7e942e80
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic-Monocyte-derived_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	MYO1A DOCK8 CD300LB LRRK1 NCKAP1L	1.56e-05	172	81	5	f6b4754a7e4b3e38030316a0ae00d932bfa87e41
ToppCell	droplet-Heart-nan-3m\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPRASP1 XIRP2 ASCC3 TRIP11 PCM1	1.74e-05	176	81	5	749b47eac5436fa34e0d243ffbc6f1897f4e431e
ToppCell	Fetal_29-31_weeks-Immune-dendritic_cell\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	DOCK8 STK17B LRRK1 SLC4A11 NCKAP1L	1.79e-05	177	81	5	c5e829bc4594761666d65cace5a9c5d19c16f187
ToppCell	LA-01._Fibroblast_I\|LA / Chamber and Cluster_Paper	EPHA6 PTPRG NCAM2 ABCA10 ABCA8	1.89e-05	179	81	5	dcb6ec9ae72b13fe388b72dace2815293fafe8ee
ToppCell	343B-Fibroblasts-Fibroblast-E-\|343B / Donor, Lineage, Cell class and subclass (all cells)	NRXN2 AZIN2 DHFR2 NCAM2 ABCA8	2.27e-05	186	81	5	1bac7825c2fe3e6cdff65026b09b9ccaa40fa27f
ToppCell	343B-Fibroblasts-Fibroblast-E\|343B / Donor, Lineage, Cell class and subclass (all cells)	NRXN2 AZIN2 DHFR2 NCAM2 ABCA8	2.27e-05	186	81	5	59db239f1864a5d4f1570c93219dbd7ac5b6db35
ToppCell	Control-Fibroblasts-Alveolar_FB\|Control / group, cell type (main and fine annotations)	PTPRG NAV2 NCAM2 ACTN2 ABCA8	2.33e-05	187	81	5	92d468dde81125d51daf7abd4703741abe1ab91c
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_dendritic-im_migrating_dendritic_(5)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	DOCK8 CD300LB SLFN11 LRRK1 NCKAP1L	2.39e-05	188	81	5	8fc15c8b78fdd1a578e34325011bc5a87a8aab31
ToppCell	COVID-19-Heart\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PTPRG MAP1B XIRP2 ACTN2 ABCA8	2.52e-05	190	81	5	918ad5037881212008f9f69d5df5da91fd01422c
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_myeloid_progenitor2_(3)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	DOCK8 CD300LB SLFN11 LRRK1 NCKAP1L	2.52e-05	190	81	5	081b7bc07b6e5685e8a91b9ae6c1141623723700
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2-AF1\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PTPRG NAV2 NCAM2 ABCA10 ABCA8	2.58e-05	191	81	5	6688cee34beee4f151ac17fccbc9c26a9aad72e1
ToppCell	nucseq-Mesenchymal-Fibroblastic-Fibroblastic_2\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PTPRG NAV2 NCAM2 ABCA10 ABCA8	2.65e-05	192	81	5	99ce9e3c4c50cf64ebb62145f2b5420efa0db309
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_monocytic-im_proliferating_myeloid_(8)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	DOCK8 CD300LB SLFN11 LRRK1 NCKAP1L	2.65e-05	192	81	5	7e7383093efaadceadd4d1f900c2d39cd690102e
ToppCell	COVID-19-Fibroblasts-Alveolar_FB\|COVID-19 / group, cell type (main and fine annotations)	PTPRG NAV2 NCAM2 ABCA10 ABCA8	2.85e-05	195	81	5	603050beeb33c331d4b2e3fa46cae3f3e0e4bdc7
ToppCell	RV-02._Fibroblast_II\|World / Chamber and Cluster_Paper	EPHA6 PTPRG NCAM2 ABCA10 ABCA8	2.85e-05	195	81	5	ce90b30dcdb56d4cd925cdb79fd9d7cefd998f48
ToppCell	RA-02._Fibroblast_II\|RA / Chamber and Cluster_Paper	PTPRG NAV2 NCAM2 ABCA10 ABCA8	2.85e-05	195	81	5	6a02ebbeb3199447ddce64d92d8809436e040eba
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	MAP1B NAV2 ASCC3 TRIP11 PCM1	2.85e-05	195	81	5	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	nucseq-Mesenchymal-Fibroblastic\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PTPRG NAV2 NCAM2 ABCA10 ABCA8	2.92e-05	196	81	5	7d8505dac15fa59935ccf592afc54b04c4c6554f
ToppCell	RA-02._Fibroblast_II\|World / Chamber and Cluster_Paper	PTPRG NAV2 NCAM2 ABCA10 ABCA8	2.92e-05	196	81	5	e8cbda03837f1f26470a9d93aa7fdaa04e08e38a
ToppCell	COVID-19-lung-Fibroblast\|lung / Disease (COVID-19 only), tissue and cell type	PTPRG NAV2 NCAM2 ABCA10 ABCA8	3.07e-05	198	81	5	df3de77216f5c5d6141ec44d01c56b942f611838
ToppCell	nucseq-Mesenchymal\|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2	PTPRG NAV2 NCAM2 ABCA10 ABCA8	3.07e-05	198	81	5	8f52243ca8b9ba68a75ae411506a3a6de258eb97
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK8 STK17B CD300LB LRRK1 NCKAP1L	3.07e-05	198	81	5	623f9d64c9e800d2d7f623392bf2f22b563f0249
ToppCell	Bronchial-NucSeq-Stromal\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	PTPRG MAP1B NCAM2 ABCA10 ABCA8	3.22e-05	200	81	5	389cc775c8419d90fb77cd794376d2160a7bf44e
ToppCell	Bronchial-NucSeq-Stromal-Fibroblastic-Fibro_alveolar\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	NAV2 NCAM2 ACTN2 ABCA10 ABCA8	3.22e-05	200	81	5	e8462395fee0a532d1e7ec7f1795f28c42af6541
ToppCell	Bronchial-10x5prime-Stromal-Peri/Epineurial_-NAF_endoneurial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	MAP1B NCAM2 CUBN ABCA10 ABCA8	3.22e-05	200	81	5	29054cf55e88e1ac81a562d8dd9af9b7c749321d
ToppCell	Tracheal-NucSeq-Stromal-Fibroblastic-Fibro_peribronchial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	MAP1B NAV2 NCAM2 ABCA10 ABCA8	3.22e-05	200	81	5	58b38f9a484ee94191091a0659ed62ebed2d4a14
ToppCell	Hippocampus-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Pvrl3\|Hippocampus / BrainAtlas - Mouse McCarroll V32	BOK EXPH5 ACTN2 UBASH3A	8.51e-05	127	81	4	9bc55cb9f4bddb274930784d12a83b9dceb35cb7
ToppCell	COVID-19-kidney-Technical/muscle_(PCT)\|COVID-19 / Disease (COVID-19 only), tissue and cell type	MYT1L EPHA6 TRPM3 CUBN	1.21e-04	139	81	4	a1945b07f177cde40e7eea03a19236ce76165857
ToppCell	LPS-antiTNF-Endothelial-Epi-like\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ZGRF1 FZD2 DNAH6 SLC4A11	1.38e-04	144	81	4	75b16adfbe84f69376e6566d531ba7919d5c5192
ToppCell	P15-Hematopoietic-Immune\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	STK17B ACTN2 UBASH3A NCKAP1L	1.66e-04	151	81	4	a54045cac65a66197e3ad2b002fa6c511102834a
ToppCell	P15-Hematopoietic-Immune-immune_cell_unspecified\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	STK17B ACTN2 UBASH3A NCKAP1L	1.66e-04	151	81	4	6b905d309f2a9b8828399b36f4942aec8696bee6
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	MYT1L EPHA6 XIRP2 NCAM2	2.02e-04	159	81	4	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	Healthy_donor-CD8+_T_naive\|World / disease group, cell group and cell class (v2)	GPRASP1 CUBN DNAH6 NOS2	2.12e-04	161	81	4	8a61395af33132783a0a37956c6f821aba5d3b1e
ToppCell	Globus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Gad1Gad2.Vipr2_(central_amygdaloid_nucleus,_medial_division,_anterodorsal_part_(CeMAD))\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	MYO1A VTCN1 SLC4A11	2.37e-04	66	81	3	6db3933fde0eee67dc5da85d7008c4fef9f684f5
ToppCell	Globus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Gad1Gad2.Vipr2_(central_amygdaloid_nucleus,_medial_division,_anterodorsal_part_(CeMAD))--\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	MYO1A VTCN1 SLC4A11	2.37e-04	66	81	3	c522722e99922caf4abe7103f1492ea96d3786a5
ToppCell	Globus_pallidus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Excitatory_Neuron.Gad1Gad2.Vipr2_(central_amygdaloid_nucleus,_medial_division,_anterodorsal_part_(CeMAD))-\|Globus_pallidus / BrainAtlas - Mouse McCarroll V32	MYO1A VTCN1 SLC4A11	2.37e-04	66	81	3	c6888ebcaba37486d9a12ad4d76669fb4e3c8fba
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1-Excitatory_Neuron.Gad1Gad2.Drd1-Lypd1_(dSPN,_patch)-\|Striatum / BrainAtlas - Mouse McCarroll V32	MYO1A XIRP2 UBASH3A	2.48e-04	67	81	3	45228b2a1e445ecba32820a282088fd0c4bb2929
ToppCell	Striatum-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Drd1-Excitatory_Neuron.Gad1Gad2.Drd1-Lypd1_(dSPN,_patch)\|Striatum / BrainAtlas - Mouse McCarroll V32	MYO1A XIRP2 UBASH3A	2.48e-04	67	81	3	4fb4381133cfc3a2d5b633eea76c4fc4ef051f08
ToppCell	metastatic_Lymph_Node-Myeloid_cells-Microglia/Mac\|Myeloid_cells / Location, Cell class and cell subclass	AZIN2 STYXL2 FZD2 P3H4	2.55e-04	169	81	4	dba8f5599aa21feef5b7fdfed2e3ab54748d80f7
ToppCell	Healthy_donor-CD8+_T_naive\|Healthy_donor / disease group, cell group and cell class (v2)	CUBN DNAH6 NOS2 SLC4A11	2.55e-04	169	81	4	66216758e581365f10c2a66714d83a606ad23af0
ToppCell	droplet-Thymus-nan-18m-Myeloid-Macrophage\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BOK LRRIQ1 VTCN1 DNAH6	2.55e-04	169	81	4	4ac21e8199de4b6917eacadc56fffc6d886ee643
ToppCell	COVID-19-Heart-CM_+_Macrophage\|Heart / Disease (COVID-19 only), tissue and cell type	GET4 XIRP2 ACTN2 NCKAP1L	2.61e-04	170	81	4	4232fe937909f93d3736988c707b8f95ce993398
ToppCell	368C-Lymphocytic-ILC\|368C / Donor, Lineage, Cell class and subclass (all cells)	HSPA4L WDR70 DHFR2 CUBN	2.67e-04	171	81	4	3b3143e4aa6520ee9c6b6f2482206ad3d8205d14
ToppCell	facs-Heart-RA-18m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK8 STK17B CD300LB NCKAP1L	2.67e-04	171	81	4	15fedb078d93ac4b7fd2945870b50a718f665487
ToppCell	368C-Lymphocytic-ILC-ILC-2\|368C / Donor, Lineage, Cell class and subclass (all cells)	HSPA4L WDR70 DHFR2 CUBN	2.67e-04	171	81	4	fd01076574dcc82bfd4a1538812500543b16794f
ToppCell	facs-Lung-18m-Hematologic-myeloid\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	DOCK8 STK17B CD300LB NCKAP1L	2.67e-04	171	81	4	4ad28ecfde3d529a09b80be908c446bd5274518e
ToppCell	facs-Heart-RA-18m-Myeloid-monocyte\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK8 STK17B CD300LB NCKAP1L	2.67e-04	171	81	4	467f53033f172905e653d85aaa6751a00e5d9e10
ToppCell	368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	SACS ZGRF1 COPG2 LRRK1	2.79e-04	173	81	4	20889aa85e36ad3bafdb91b91e43964493c949f9
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-5w-Mesenchymal-Cilia-bearing_cell\|5w / Sample Type, Dataset, Time_group, and Cell type.	PTPRG MED16 DNAH6 DHX30	2.79e-04	173	81	4	d4cbeae262abfa30d8c5452285d3261a96875610
ToppCell	AT1_cells-Donor_03\|World / lung cells shred on cell class, cell subclass, sample id	EXPH5 NAV2 ABCA8 ALPG	2.79e-04	173	81	4	3afca2a429c634af0220c1aa19ce4cf4ee3e8b3e
ToppCell	368C-Epithelial_cells-Epithelial-J_(AT1-AT2_progenitors)-\|Epithelial_cells / Donor, Lineage, Cell class and subclass (all cells)	SACS ZGRF1 COPG2 LRRK1	2.79e-04	173	81	4	46e601b7938b1dd0aa3df7aa056c4bd07b1620c1
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CTCFL STX3 CD300LB UBASH3A	2.91e-04	175	81	4	1b35acece23712ab7e3f92d9d68266efd38b3ef5
ToppCell	ASK428-Immune-B_cell\|Immune / Donor, Lineage and Cell class of Lung cells from Dropseq	MSH6 CDC42BPA EXPH5 ERMN	2.91e-04	175	81	4	e0979e5795a49b4e5c9b88e7fe6b7bda7a413a6c
ToppCell	facs-Marrow-Granulocytes-3m-Myeloid-basophil\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CTCFL STX3 CD300LB UBASH3A	2.91e-04	175	81	4	a9f88054e2c28d604c65ed785f63021aadb7f4c8
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Epithelial-mature_enterocytic-Enterocyte\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	LRRC8E MYO1A ANXA4 CUBN	2.98e-04	176	81	4	24eedbbb406d788630bb16678cceef4492d3999c
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Immune-Myeloid-Monocytic\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	DOCK8 CD300LB LRRK1 NCKAP1L	2.98e-04	176	81	4	926ed37e636fe4dd3a18731cea15761f0c2c285a
ToppCell	droplet-Kidney-nan-18m-Epithelial-collecting_duct_principal_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPRASP1 EPHA6 SYT12 EXPH5	2.98e-04	176	81	4	533d544852038c0612aacf87f4b1c88ff7aace82
ToppCell	Control-Lymphocytic_NKT-T_cells-T-cells\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK8 STK17B UBASH3A NCKAP1L	3.11e-04	178	81	4	910f8bea19d335455aba24e6a07b4834b709db5d
ToppCell	Control-Lymphocytic_NKT-T_cells\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK8 STK17B UBASH3A NCKAP1L	3.17e-04	179	81	4	d892d9496f1c33e23312092591eb2e968e736f7d
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5-Exc_L4-5_RORB_HNRNPA1P46\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	EPHA6 TRPM3 LRRK1 DNAH6	3.24e-04	180	81	4	8923a42a6db9c6e9f3ce2ca9530e620dfea700ba
ToppCell	368C-Lymphocytic-ILC-ILC-2\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	HSPA4L WDR70 DHFR2 CUBN	3.24e-04	180	81	4	eb5a57604c7f2ad256c300085dbf5069d0ae1ad0
ToppCell	368C-Lymphocytic-ILC\|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)	HSPA4L WDR70 DHFR2 CUBN	3.24e-04	180	81	4	ddba4dc3bbcfe4e4a22400be73bbc62d3ff27d3c
ToppCell	droplet-Lung-3m-Mesenchymal-fibroblast-adventitial_fibroblast-adventitial_fibroblast_l25\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FLNB SYT12 SACS SLC4A11	3.24e-04	180	81	4	c4068fe47408cfd899131a85fa4b7e5908926f94
ToppCell	droplet-Lung-nan-18m-Myeloid-Proliferating_Alveolar_Macrophage\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TRPM3 HSPA4L ZGRF1 ALPG	3.24e-04	180	81	4	43fd5c498a87bb078d101298b472656f3294686a
ToppCell	RA-01._Fibroblast_I\|World / Chamber and Cluster_Paper	PTPRG NAV2 NCAM2 ABCA8	3.31e-04	181	81	4	2b6ddeb53a79a658e2ba78527ff48c155b20daa6
ToppCell	3'-GW_trimst-2-SmallIntestine-Neuronal-Glial_immature-Glia_2_(ELN+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MAP1B TRPM3 NCAM2 ABCA8	3.31e-04	181	81	4	a436e7e4c36403257ea90160a58ca0d6d7c0cdfc
ToppCell	5'-GW_trimst-2-LargeIntestine-Neuronal-Glial_immature-Glia_2_(ELN+)\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MAP1B NRXN2 TRPM3 ABCA8	3.31e-04	181	81	4	098dbb3e0ff531c9720a233123250c1e39a97d4c
ToppCell	PND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1-AT1_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYT1L EXPH5 NAV2 FZD2	3.38e-04	182	81	4	573771130247e869e4e58f22d4a1cb31989635cf
ToppCell	PND14-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT1\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	MYT1L EXPH5 NAV2 FZD2	3.38e-04	182	81	4	6cfaa2b3b3974c13b01c943f4adb70768dcc35e4
ToppCell	21-Trachea-Mesenchymal-Mesenchyme_SERPINF1-high\|Trachea / Age, Tissue, Lineage and Cell class	NRXN2 TRPM3 NCAM2 ABCA8	3.38e-04	182	81	4	354dcdb01360597f68c4fe157a682aee1c0b8bb1
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|COVID-19 / Disease (COVID-19 only), tissue and cell type	PTPRG MAP1B ABCA10 ABCA8	3.38e-04	182	81	4	fbd5e332df73bf7141c822fa67b76367dc962017
ToppCell	droplet-Kidney-nan-21m-Epithelial-Epcam____podocyte-2\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC8E BOK MAP1B SLC4A11	3.45e-04	183	81	4	877559962b2b073fc2a9f1b64a76e17895e40a97
ToppCell	Control-Lymphocytic_NKT-iNKT/MAIT\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK8 STK17B UBASH3A NCKAP1L	3.45e-04	183	81	4	59e8d07556390828f7557ba3fd2f7d49851498b7
ToppCell	PCW_07-8.5-Hematologic_Myeloid-Hem_Myeloid_dendritic-im_conventional_dendritic_(19)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	DOCK8 SLFN11 LRRK1 NCKAP1L	3.45e-04	183	81	4	24679153b654c148dbd572e9013c0a6e58718ada
ToppCell	Control-Lymphocytic_NKT-iNKT/MAIT-iNKT-MAIT\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK8 STK17B UBASH3A NCKAP1L	3.45e-04	183	81	4	2c5707ada3442eb7100a2a5f9438d5a2ac53a9e1
ToppCell	droplet-Lung-21m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|21m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	FLNB CDC42BPA MAP1B CUBN	3.52e-04	184	81	4	087666ba949b129c53d7ace40f9e543e3875a7de
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	MAP1B NAV2 ABCA10 ABCA8	3.52e-04	184	81	4	e061e85c4bb19f49f6451ddd7a9077d7378ee365
ToppCell	droplet-Marrow-nan-3m\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK8 ASCC3 TRIP11 PCM1	3.52e-04	184	81	4	1154a5ad7b8512272b7476f949ddac350910bfb7
ToppCell	Control-Lymphocytic_NKT\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DOCK8 STK17B UBASH3A NCKAP1L	3.60e-04	185	81	4	59d68e119f58b35bab36294758f6b2e25fd8f5c0
ToppCell	15-Trachea-Epithelial-Multiciliated_precursor\|Trachea / Age, Tissue, Lineage and Cell class	LRRIQ1 HSPA4L SLFN11 PCM1	3.60e-04	185	81	4	9a8b8360d99375b726ca8e3c9a3f9b08919892d7
ToppCell	MS-matDC\|MS / Condition, Cell_class and T cell subcluster	LRRC8E MAP1B NRXN2 SLC4A11	3.60e-04	185	81	4	46bd897349598d85e718e25f9a045d2247723c61
ToppCell	MS-matDC-\|MS / Condition, Cell_class and T cell subcluster	LRRC8E MAP1B NRXN2 SLC4A11	3.60e-04	185	81	4	9fbe70d3a7b106fb31e13b7f95029785f28ca6f4
ToppCell	COVID-19-Fibroblasts-Adventitial_FB\|COVID-19 / group, cell type (main and fine annotations)	PTPRG NAV2 ABCA10 ABCA8	3.60e-04	185	81	4	a5aebf2b9b05b550d021272731d68af9a6b1229d
ToppCell	3'-GW_trimst-1-LargeIntestine-Hematopoietic-Myeloid-cDC2\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DOCK8 STK17B CD300LB NCKAP1L	3.60e-04	185	81	4	e592c27f711d13bfc6546893acaab4c8600b0be1
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-24m-Neuronal-interneuron\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SYT12 MAP1B NRXN2 EXPH5	3.67e-04	186	81	4	d1d01ce46e62944aa9864eda47e8401b5f0d2bdc
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-Classical_Dendritic_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	STK17B LRRK1 ERMN NCKAP1L	3.67e-04	186	81	4	305f1726b8b5add32f1c29c74991ff34f42e0da7
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	LRRIQ1 DOCK8 DNAH6 SLC4A11	3.67e-04	186	81	4	5c4ffe4e4d5536ae9f8794277fe032c693e7dd56
ToppCell	5'-Adult-SmallIntestine-Epithelial-Tuft-related-Microfold_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HEBP2 ANXA4 VTCN1 SLC4A11	3.67e-04	186	81	4	6d8dd6d0403d149cb6edb346581fe6c248036785
ToppCell	LA-01._Fibroblast_I\|World / Chamber and Cluster_Paper	NAV2 NCAM2 ABCA10 ABCA8	3.75e-04	187	81	4	4ea486991f66c29728d127171a07b81404ec0b78
ToppCell	COPD-Stromal-Pericyte\|Stromal / Disease state, Lineage and Cell class	STX3 MAP1B ABCB11 COPG2	3.75e-04	187	81	4	406ecd1dabb3ed8d871aef159f7bd1e383434953
ToppCell	Epithelial-Epithelial-D_(Ciliated)\|Epithelial / shred on cell class and cell subclass (v4)	LRRIQ1 MAP1B HSPA4L DNAH6	3.82e-04	188	81	4	8f30535a32968a81a304315a49c0d90a77d36948
ToppCell	3'-GW_trimst-1-LargeIntestine-Neuronal-neurons_A-Branch_A3_(IPAN/IN)\|GW_trimst-1 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	MYT1L MAP1B NRXN2 NCAM2	3.82e-04	188	81	4	bd091503f580dedab40e0996273101285d24b586
ToppCell	PND01-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRRIQ1 HSPA4L DNAH6 NOS2	3.90e-04	189	81	4	b55de812043b670cbde810d7d42f45909b6d66ef
ToppCell	Control-B_intermediate-6\|Control / disease group and sub_cluster of B and Plasma cells(res = 0.5)	FLNB TBC1D9B SACS ANXA4	3.90e-04	189	81	4	11cb9a16f1de8f60af2073ed7ea6d4f41c02f299
ToppCell	PCW_13-14-Immune_Lymphocytic-Immune_Lymphocytic_NK/ILC-im_ILC3_(12)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	DOCK8 NCR2 UBASH3A NCKAP1L	3.90e-04	189	81	4	78dcda09109a5cfb04ba069f16ec80987b3ad432
ToppCell	Macrophages-Cryobiopsy_01\|World / lung cells shred on cell class, cell subclass, sample id	DOCK8 STYXL2 SLFN11 NCKAP1L	3.90e-04	189	81	4	c05b4b565c0ce56dbb45fc9503654a2ec1a7e1e9
ToppCell	PND01-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated\|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	LRRIQ1 HSPA4L DNAH6 NOS2	3.90e-04	189	81	4	4e83e49d1265ffe507fdb72924c77c4d1c73f0bd
Drug	Demecarium bromide [56-94-0]; Down 200; 5.6uM; MCF7; HT_HG-U133A	FLNB TBC1D9B MAP1B EXPH5 ACP2 U2AF2 PCM1	6.28e-06	198	80	7	6269_DN
Drug	Clonidine hydrochloride [4205-91-8]; Down 200; 15uM; MCF7; HT_HG-U133A	CDC42BPA SYT12 KDM4C MED16 ACP2 TRIP11 PCM1	6.49e-06	199	80	7	6814_DN
Disease	Intellectual Disability	MYT1L RALA MAP1B NRXN2 TRPM3 SACS DOCK8 MTOR ASCC3	3.12e-06	447	79	9	C3714756
Disease	Cholangitis, Sclerosing	UBASH3A NOS2	1.05e-04	6	79	2	C0008313
Disease	Primary sclerosing cholangitis	UBASH3A NOS2	1.96e-04	8	79	2	C0566602
Disease	Thyroid carcinoma	MSH6 MTOR PRKAR1A	2.26e-04	44	79	3	C0549473
Disease	Disproportionate short stature	FLNB PRKAR1A TRIP11	1.17e-03	77	79	3	C0878659
Disease	superior temporal gyrus volume measurement	BOK CUBN	1.18e-03	19	79	2	EFO_0010331
Disease	HIV-1 infection, Susceptibility to viral and mycobacterial infections	KDM4C NAV2	1.44e-03	21	79	2	EFO_0000180, Orphanet_391311
Disease	venous thromboembolism	TRPM3 CTNNBIP1 NAV2 NCAM2 NCR2 BRWD1	1.48e-03	460	79	6	EFO_0004286
Disease	Hypermetropia, Myopia	KDM4C CUBN TNPO3 C2CD5	1.68e-03	189	79	4	HP_0000540, HP_0000545
Disease	Neurodevelopmental Disorders	MYT1L DOCK8 DHX30	2.02e-03	93	79	3	C1535926

Protein segments in the cluster

Peptide	Gene	Start	Entry
MSRGDRFSEDSRFIT	PTPRG	701	P23470
FQSFIDFMTRETADT	ACTN2	811	P35609
FFVETMSGDERSDEI	CTCFL	201	Q8NI51
MESTSFSRDDIVLDL	ABCA10	916	Q8WWZ4
SESDFVMVEEGFSTR	AZIN2	6	Q96A70
DATEDDMLARTFSRG	ABCB11	671	O95342
SFSMDSDDVRQAARL	BTBD11	521	A6QL63
SRPMSANEDFDFDTE	ANKRD26P1	276	Q6NSI1
RMAQFDTDTFLDTLT	ACSM4	296	P0C7M7
LEDDIRSDTSFMFQR	ANXA4	136	P09525
SFEMTDDDSAIRALT	DHX30	226	Q7L2E3
RSSVFAAEIMDAFDR	BOK	6	Q9UMX3
TEMESFAATADFREQ	RALA	96	P11233
REISMEDEATTLFRA	RASA1	776	P20936
VFDARSCSTAREMFE	NOS2	211	P35228
FDDLVRDFNSIFSDM	HAX1	81	O00165
HSAESDVTRFLFDEM	H2AP	96	O75409
SSMEEDKFSRSALRD	MAP1B	1211	P46821
FFTVTMTDLREEDSG	NCR2	91	O95944
QSEVRDFSAMAFITD	LRRK1	1121	Q38SD2
EVSRVDGMDDASSFR	MYO1A	231	Q9UBC5
DRAEMTVFVRSFDGF	HEBP2	131	Q9Y5Z4
IFSSFRDSVQEIAEM	FANCM	481	Q8IYD8
RTFEMSDFIVDTRDA	FLNB	2016	O75369
TGSDFSMFEALRDTI	PCM1	1371	Q15154
DGSMFFSQEETRFAR	FZD2	231	Q14332
TEAEDVSLRFMSQRA	NRXN2	751	Q9P2S2
FSAEEFSDISEMRAL	NCKAP1L	826	P55160
ARFSTASDMRFEDTF	KDM4C	996	Q9H3R0
SRKSFSSSDRDFEMI	EXPH5	496	Q8NEV8
EYSFRSVREETGMGD	LRRC8E	341	Q6NSJ5
SHFGTDDRFRMDSRF	NOL8	871	Q76FK4
DRIMSGESTFFVELS	MSH6	1181	P52701
DLSLQETSADEMTFR	ERMN	96	Q8TAM6
VSREDTDLDLFSMTN	LRRIQ1	1676	Q96JM4
AFTMDLRSDDQDLTR	MED16	46	Q9Y2X0
YVRSTDFDRTLMSAE	ACP2	101	P11117
SRAYRALTETIMFDD	ALPG	341	P10696
VTASGFRLRFESSME	CUBN	2436	O60494
MTFRATDSEFDLTNI	DNAH6	1	Q9C0G6
RFSDRFMDDITTIVN	DOCK8	1011	Q8NF50
SERTFYLVAETREDM	GAB4	126	Q2WGN9
FGTTEATEAFFAMTR	COPG2	61	Q9UBF2
TRISGDLSSEEERFM	BRWD1	411	Q9NSI6
VTRIMQDFESDTFFS	DHFR2	136	Q86XF0
RSDIFDAMFSVSFIA	PRKAR1A	146	P10644
MFRDLDADFRTQFSD	SACS	2666	Q9NZJ4
NMFFIRETTSLREEG	C2CD5	896	Q86YS7
GFTTFDLISRMSIDD	EPHA6	986	Q9UF33
MERTNDSTSTEFFLV	OR13C8	1	Q8NGS7
ELREMSQEESTRFYD	MTOR	51	P42345
MRSASQFTRDFIRDS	GPRASP1	1181	Q5JY77
EREEASFESCFMRVS	SYT12	181	Q8IV01
EVARTFATMFSDIAF	SLC4A11	251	Q8NBS3
FEIEKRESMFVFSSD	SESN1	301	Q9Y6P5
EYSTSRGFRSEVDMF	GET4	181	Q7L5D6
MSRSGSFRDGFEEES	NAV2	1621	Q8IVL1
DSSMVSKRFRFDDSL	STK17B	346	O94768
SETSVRSMDSREAFC	SLFN11	136	Q7Z7L1
MRDEEFSVSSVLASD	CDC42BPA	1136	Q5VT25
FMDEFFSEIEETRLN	STX3	31	Q13277
SIRVDTRDQELFFSM	TBC1D9B	216	Q66K14
TMDLGRVDTFNESRF	ABCA8	61	O94911
MIRFEERTGYFSSTD	ASCC3	966	Q8N3C0
TFTVTMEGLRRDDAD	CD300LB	86	A8K4G0
DVVMAFSRSETEDRR	CTNNBIP1	66	Q9NSA3
SSRMRSDGFDEESQR	NKAPD1	56	Q6ZUT1
MRTTFQEESAFISEA	XIRP2	3331	A4UGR9
QQEFLEDFRRTMASS	TTLL8	201	A6PVC2
TAERGEEMTFSCRAS	NCAM2	221	O15394
SFFTDAERRSVMAAA	HSPA4L	146	O95757
SRSIDFEDITSMDTR	TRPM3	1481	Q9HCF6
TFDLEAMFEQTRRTA	WDR70	36	Q9NW82
NSGDFRSSTEDMERA	P3H4	216	Q92791
RKFTQSFMRSEEEGE	STYXL2	1086	Q5VZP5
EETDDFGEFRMRVSD	TNPO3	391	Q9Y5L0
RFESSGQDMFRETIQ	TRIP11	1146	Q15643
EFRSVDETTQAMAFD	U2AF2	201	P26368
VSTFSLNSRDEDFMV	ZGRF1	1006	Q86YA3
LNSRDEDFMVEFSET	ZGRF1	1011	Q86YA3
SEQDEMFRGRTAVFA	VTCN1	91	Q7Z7D3
ADVIREFAMTFATEA	UBASH3A	166	P57075
IAEDAAYRARTESEM	MYT1L	211	Q9UL68