Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	low-density lipoprotein particle receptor activity	LRP1B LDLR LRP1 LRP2 SORL1	3.24e-08	16	122	5	GO:0005041
GeneOntologyMolecularFunction	lipoprotein particle receptor activity	LRP1B LDLR LRP1 LRP2 SORL1	1.48e-07	21	122	5	GO:0030228
GeneOntologyMolecularFunction	growth factor binding	GPC1 RHBDF2 RPS2 ACVR1B EGFR WFIKKN2 LRP2 AGRN	5.26e-06	156	122	8	GO:0019838
GeneOntologyMolecularFunction	cargo receptor activity	LRP1B LDLR LRP1 LRP2 SORL1	1.74e-04	85	122	5	GO:0038024
GeneOntologyMolecularFunction	olfactory receptor binding	RTP1 RTP2	5.47e-04	6	122	2	GO:0031849
GeneOntologyBiologicalProcess	positive regulation of lysosomal protein catabolic process	LDLR LRP1 LRP2	1.81e-06	5	118	3	GO:1905167
GeneOntologyBiologicalProcess	positive regulation of protein catabolic process in the vacuole	LDLR LRP1 LRP2	6.28e-06	7	118	3	GO:1904352
GeneOntologyBiologicalProcess	enzyme-linked receptor protein signaling pathway	GPC1 ONECUT2 SPRY1 RHBDF2 ITGA8 ACVR1B PTPRU TSPAN9 ADAMTS12 BMPR1B EGF EGFR WFIKKN2 LRP1 LRP2 PRMT1 HES1 PLAUR AGRN SORL1	1.24e-05	1186	118	20	GO:0007167
GeneOntologyBiologicalProcess	regulation of cellular response to growth factor stimulus	GPC1 ONECUT2 SPRY1 ITGA8 ADAMTS12 WFIKKN2 LRP1 LRP2 PRMT1 HES1 SORL1	2.49e-05	412	118	11	GO:0090287
GeneOntologyBiologicalProcess	regulation of transmembrane receptor protein serine/threonine kinase signaling pathway	ONECUT2 SPRY1 ITGA8 ACVR1B WFIKKN2 LRP1 LRP2 PRMT1 HES1 SORL1	3.11e-05	347	118	10	GO:0090092
GeneOntologyBiologicalProcess	regulation of lysosomal protein catabolic process	LDLR LRP1 LRP2	3.87e-05	12	118	3	GO:1905165
GeneOntologyBiologicalProcess	transforming growth factor beta receptor superfamily signaling pathway	ONECUT2 SPRY1 ITGA8 ACVR1B BMPR1B WFIKKN2 LRP1 LRP2 PRMT1 HES1 SORL1	5.02e-05	445	118	11	GO:0141091
GeneOntologyBiologicalProcess	glial cell activation	LDLR EGFR TLR3 LRP1 ATM	5.06e-05	70	118	5	GO:0061900
GeneOntologyBiologicalProcess	negative regulation of hydrolase activity	SPRY1 INTS1 GMIP BIRC6 PPP1R26 WFIKKN2 LRP1 PLAUR PCID2	5.49e-05	298	118	9	GO:0051346
GeneOntologyBiologicalProcess	regulation of protein catabolic process in the vacuole	LDLR LRP1 LRP2	6.35e-05	14	118	3	GO:1904350
GeneOntologyBiologicalProcess	cellular response to fatty acid	CPS1 CPT1A LDLR HES1	9.63e-05	42	118	4	GO:0071398
GeneOntologyBiologicalProcess	cell surface receptor protein serine/threonine kinase signaling pathway	ONECUT2 SPRY1 ITGA8 ACVR1B BMPR1B WFIKKN2 LRP1 LRP2 PRMT1 HES1 SORL1	1.02e-04	482	118	11	GO:0007178
GeneOntologyBiologicalProcess	cellular response to growth factor stimulus	GPC1 ONECUT2 SPRY1 ITGA8 ACVR1B CPS1 ADAMTS12 BMPR1B EGFR WFIKKN2 LRP1 LRP2 PRMT1 HES1 SORL1	1.03e-04	850	118	15	GO:0071363
GeneOntologyBiologicalProcess	response to growth factor	GPC1 ONECUT2 SPRY1 ITGA8 ACVR1B CPS1 ADAMTS12 BMPR1B EGFR WFIKKN2 LRP1 LRP2 PRMT1 HES1 SORL1	1.56e-04	883	118	15	GO:0070848
GeneOntologyBiologicalProcess	negative regulation of lymphoid progenitor cell differentiation	HES1 PCID2	1.93e-04	4	118	2	GO:1905457
GeneOntologyCellularComponent	cell surface	SELE GPC1 RTP1 ANK3 RTP2 ITGA8 ACVR1B ULBP3 LDLR EGFR TLR3 LRP1 LRP2 PLAUR CTSB AGRN UNC5D SORL1	7.06e-05	1111	121	18	GO:0009986
GeneOntologyCellularComponent	clathrin-coated endocytic vesicle membrane	LDLR TYRP1 EGF EGFR LRP2	9.57e-05	79	121	5	GO:0030669
GeneOntologyCellularComponent	clathrin-coated endocytic vesicle	LDLR TYRP1 EGF EGFR LRP2	3.04e-04	101	121	5	GO:0045334
GeneOntologyCellularComponent	alpha DNA polymerase:primase complex	POLA1 PRIM1	3.29e-04	5	121	2	GO:0005658
GeneOntologyCellularComponent	endosome	GPC1 CLEC18A CLEC18B CARMIL1 CLEC18C BIRC6 LDLR RPS6KC1 TYRP1 EGFR ABCA5 TLR3 LRP1 LRP2 TRAPPC10 CTSB SORL1	3.99e-04	1167	121	17	GO:0005768
GeneOntologyCellularComponent	nuclear envelope	ZNF383 POLA1 SYNE1 INTS1 RB1CC1 FAF1 EGFR CCNI PCID2 KPNA1 SORL1	4.14e-04	560	121	11	GO:0005635
GeneOntologyCellularComponent	extracellular matrix	GPC1 ADAMTSL1 ADAMTSL3 TSPAN9 ADAMTS12 TLR3 ALB LGR6 CTSB MUC5AC AGRN MUC6	4.28e-04	656	121	12	GO:0031012
GeneOntologyCellularComponent	Golgi lumen	GPC1 RHBDF2 MUC5AC AGRN MUC6	4.32e-04	109	121	5	GO:0005796
GeneOntologyCellularComponent	external encapsulating structure	GPC1 ADAMTSL1 ADAMTSL3 TSPAN9 ADAMTS12 TLR3 ALB LGR6 CTSB MUC5AC AGRN MUC6	4.39e-04	658	121	12	GO:0030312
GeneOntologyCellularComponent	endolysosome	LDLR TLR3 CTSB	6.85e-04	30	121	3	GO:0036019
GeneOntologyCellularComponent	lysosome	GPC1 ANK3 RB1CC1 LDLR RPS6KC1 EGF ABCA5 TLR3 LRP1 LRP2 PRMT1 CTSB AGRN	8.48e-04	811	121	13	GO:0005764
GeneOntologyCellularComponent	lytic vacuole	GPC1 ANK3 RB1CC1 LDLR RPS6KC1 EGF ABCA5 TLR3 LRP1 LRP2 PRMT1 CTSB AGRN	8.48e-04	811	121	13	GO:0000323
GeneOntologyCellularComponent	clathrin-coated pit	SELE LDLR LRP1 LRP2	1.20e-03	80	121	4	GO:0005905
GeneOntologyCellularComponent	endocytic vesicle membrane	LDLR TYRP1 EGF EGFR LRP1 LRP2	1.48e-03	212	121	6	GO:0030666
GeneOntologyCellularComponent	clathrin-coated vesicle membrane	LDLR TYRP1 EGF EGFR LRP2	1.66e-03	147	121	5	GO:0030665
GeneOntologyCellularComponent	sarcoplasmic reticulum	CACNA1S ANK3 CLEC18B ITPR2	1.71e-03	88	121	4	GO:0016529
GeneOntologyCellularComponent	serine/threonine protein kinase complex	CDKN1A ACVR1B RB1CC1 STRADB CCNI	2.21e-03	157	121	5	GO:1902554
GeneOntologyCellularComponent	axonal growth cone	LRP1 LRP2 AGRN	2.25e-03	45	121	3	GO:0044295
GeneOntologyCellularComponent	vacuole	GPC1 ANK3 RB1CC1 LDLR RPS6KC1 EGF ABCA5 TLR3 LRP1 LRP2 PRMT1 CTSB AGRN	2.44e-03	913	121	13	GO:0005773
GeneOntologyCellularComponent	keratin filament	KRT78 KRTAP10-7 KRTAP10-6 KRTAP10-12	2.45e-03	97	121	4	GO:0045095
GeneOntologyCellularComponent	clathrin-coated vesicle	LDLR TYRP1 EGF EGFR LRP1 LRP2	2.59e-03	237	121	6	GO:0030136
Domain	Ldl_recept_b	LRP1B LDLR EGF LRP1 LRP2 SORL1	1.70e-10	14	119	6	PF00058
Domain	LDLRB	LRP1B LDLR EGF LRP1 LRP2 SORL1	1.70e-10	14	119	6	PS51120
Domain	LY	LRP1B LDLR EGF LRP1 LRP2 SORL1	2.81e-10	15	119	6	SM00135
Domain	LDLR_classB_rpt	LRP1B LDLR EGF LRP1 LRP2 SORL1	2.81e-10	15	119	6	IPR000033
Domain	EGF_3	SELE CLEC18A CLEC18B CLEC18C LRP1B LDLR FAT2 EGF LRP1 LRP2 C9 AGRN SORL1	3.42e-09	235	119	13	PS50026
Domain	EGF-like_dom	SELE CLEC18A CLEC18B CLEC18C LRP1B LDLR FAT2 EGF LRP1 LRP2 C9 AGRN SORL1	6.86e-09	249	119	13	IPR000742
Domain	EGF-like_CS	SELE CLEC18A CLEC18B CLEC18C LRP1B LDLR FAT2 EGF LRP1 LRP2 C9 AGRN SORL1	1.20e-08	261	119	13	IPR013032
Domain	EGF_2	SELE CLEC18A CLEC18B CLEC18C LRP1B LDLR FAT2 EGF LRP1 LRP2 C9 AGRN SORL1	1.44e-08	265	119	13	PS01186
Domain	EGF	SELE CLEC18A CLEC18B CLEC18C LRP1B LDLR FAT2 EGF LRP1 LRP2 AGRN SORL1	3.44e-08	235	119	12	SM00181
Domain	EGF_1	SELE CLEC18A CLEC18B CLEC18C LRP1B LDLR FAT2 EGF LRP1 LRP2 C9 AGRN	8.44e-08	255	119	12	PS00022
Domain	-	LRP1B LDLR EGF LRP1 LRP2 SORL1	1.62e-07	39	119	6	2.120.10.30
Domain	LDLR_class-A_CS	LRP1B LDLR LRP1 LRP2 C9 SORL1	1.90e-07	40	119	6	IPR023415
Domain	Ldl_recept_a	LRP1B LDLR LRP1 LRP2 C9 SORL1	3.92e-07	45	119	6	PF00057
Domain	6-blade_b-propeller_TolB-like	LRP1B LDLR EGF LRP1 LRP2 SORL1	4.48e-07	46	119	6	IPR011042
Domain	-	LRP1B LDLR LRP1 LRP2 C9 SORL1	4.48e-07	46	119	6	4.10.400.10
Domain	LDLRA_1	LRP1B LDLR LRP1 LRP2 C9 SORL1	5.81e-07	48	119	6	PS01209
Domain	LDrepeatLR_classA_rpt	LRP1B LDLR LRP1 LRP2 C9 SORL1	6.59e-07	49	119	6	IPR002172
Domain	LDLa	LRP1B LDLR LRP1 LRP2 C9 SORL1	6.59e-07	49	119	6	SM00192
Domain	LDLRA_2	LRP1B LDLR LRP1 LRP2 C9 SORL1	6.59e-07	49	119	6	PS50068
Domain	EGF_CA	LRP1B LDLR FAT2 EGF LRP1 LRP2 AGRN	1.31e-05	122	119	7	SM00179
Domain	EGF-like_Ca-bd_dom	LRP1B LDLR FAT2 EGF LRP1 LRP2 AGRN	1.45e-05	124	119	7	IPR001881
Domain	EGF	SELE LRP1B FAT2 EGF LRP1 LRP2 AGRN	1.61e-05	126	119	7	PF00008
Domain	SCGB	SCGB2A1 SCGB1C2 SCGB1C1	2.06e-05	9	119	3	PS51311
Domain	Uteroglobin	SCGB2A1 SCGB1C2 SCGB1C1	2.93e-05	10	119	3	PF01099
Domain	Secretoglobin	SCGB2A1 SCGB1C2 SCGB1C1	4.01e-05	11	119	3	IPR016126
Domain	DUF5050	LRP1B LRP1	4.03e-05	2	119	2	IPR032485
Domain	Secretoglobin_1C1/2	SCGB1C2 SCGB1C1	4.03e-05	2	119	2	IPR028659
Domain	DUF5050	LRP1B LRP1	4.03e-05	2	119	2	PF16472
Domain	TSP_1	ADAMTSL1 ADAMTSL3 ADAMTS12 C9 UNC5D	5.05e-05	63	119	5	PF00090
Domain	TSP1	ADAMTSL1 ADAMTSL3 ADAMTS12 C9 UNC5D	5.87e-05	65	119	5	SM00209
Domain	TSP1_rpt	ADAMTSL1 ADAMTSL3 ADAMTS12 C9 UNC5D	5.87e-05	65	119	5	IPR000884
Domain	TSP1	ADAMTSL1 ADAMTSL3 ADAMTS12 C9 UNC5D	5.87e-05	65	119	5	PS50092
Domain	Growth_fac_rcpt_	LRP1B LDLR EGF EGFR LRP1 LRP2 C9	6.35e-05	156	119	7	IPR009030
Domain	TIL_dom	LRP2 MUC5AC MUC6	8.72e-05	14	119	3	IPR002919
Domain	CAP	CLEC18A CLEC18B CLEC18C	1.09e-04	15	119	3	PF00188
Domain	SCP	CLEC18A CLEC18B CLEC18C	1.09e-04	15	119	3	SM00198
Domain	Allrgn_V5/Tpx1	CLEC18A CLEC18B CLEC18C	1.09e-04	15	119	3	IPR001283
Domain	-	CLEC18A CLEC18B CLEC18C	1.09e-04	15	119	3	3.40.33.10
Domain	CAP_domain	CLEC18A CLEC18B CLEC18C	1.09e-04	15	119	3	IPR014044
Domain	C-type_lectin_CS	SELE CLEC18A CLEC18B CLEC18C	1.60e-04	43	119	4	IPR018378
Domain	EGF_CA	LRP1B LDLR EGF LRP1 LRP2	2.23e-04	86	119	5	PF07645
Domain	PLAC	ADAMTSL1 ADAMTSL3 ADAMTS12	2.27e-04	19	119	3	PS50900
Domain	PLAC	ADAMTSL1 ADAMTSL3 ADAMTS12	2.27e-04	19	119	3	IPR010909
Domain	EGF_Ca-bd_CS	LRP1B LDLR EGF LRP1 LRP2	3.90e-04	97	119	5	IPR018097
Domain	R-trans_p	RTP1 RTP2	3.98e-04	5	119	2	IPR026096
Domain	EGF_CA	LRP1B LDLR EGF LRP1 LRP2	4.28e-04	99	119	5	PS01187
Domain	ASX_HYDROXYL	LRP1B LDLR EGF LRP1 LRP2	4.49e-04	100	119	5	PS00010
Domain	Peptidase_M12B_ADAM-TS	ADAMTSL1 ADAMTSL3 ADAMTS12	4.63e-04	24	119	3	IPR013273
Domain	EGF-type_Asp/Asn_hydroxyl_site	LRP1B LDLR EGF LRP1 LRP2	5.86e-04	106	119	5	IPR000152
Domain	cEGF	LRP1B LRP1 LRP2	5.89e-04	26	119	3	PF12662
Domain	cEGF	LRP1B LRP1 LRP2	5.89e-04	26	119	3	IPR026823
Domain	GS_dom	ACVR1B BMPR1B	8.28e-04	7	119	2	IPR003605
Domain	GS	ACVR1B BMPR1B	8.28e-04	7	119	2	PS51256
Domain	zf-3CxxC	RTP1 RTP2	8.28e-04	7	119	2	PF13695
Domain	TGF_beta_GS	ACVR1B BMPR1B	8.28e-04	7	119	2	PF08515
Domain	GS	ACVR1B BMPR1B	8.28e-04	7	119	2	SM00467
Domain	Arm	ARMC8 KPNA1 ARMC6	9.95e-04	31	119	3	PF00514
Domain	zf-3CxxC	RTP1 RTP2	1.10e-03	8	119	2	SM01328
Domain	Znf-3CxxC	RTP1 RTP2	1.10e-03	8	119	2	IPR027377
Domain	ZU5	ANK3 UNC5D	1.41e-03	9	119	2	SM00218
Domain	C_TYPE_LECTIN_1	SELE CLEC18A CLEC18B CLEC18C	1.71e-03	80	119	4	PS00615
Domain	Activin_recp	ACVR1B BMPR1B	1.75e-03	10	119	2	PF01064
Domain	Activin_recp	ACVR1B BMPR1B	1.75e-03	10	119	2	IPR000472
Domain	ZU5	ANK3 UNC5D	1.75e-03	10	119	2	PS51145
Domain	Keratin_B2_2	KRTAP10-7 KRTAP10-6 KRTAP10-12	1.95e-03	39	119	3	PF13885
Domain	Lectin_C	SELE CLEC18A CLEC18B CLEC18C	2.04e-03	84	119	4	PF00059
Domain	CLECT	SELE CLEC18A CLEC18B CLEC18C	2.04e-03	84	119	4	SM00034
Domain	ARM_REPEAT	ARMC8 KPNA1 ARMC6	2.10e-03	40	119	3	PS50176
Domain	ARM	ARMC8 KPNA1 ARMC6	2.10e-03	40	119	3	SM00185
Domain	C_TYPE_LECTIN_2	SELE CLEC18A CLEC18B CLEC18C	2.13e-03	85	119	4	PS50041
Domain	C-type_lectin-like	SELE CLEC18A CLEC18B CLEC18C	2.23e-03	86	119	4	IPR001304
Domain	TGFB_receptor	ACVR1B BMPR1B	2.55e-03	12	119	2	IPR000333
Domain	C8	MUC5AC MUC6	2.55e-03	12	119	2	PF08742
Domain	TIL	MUC5AC MUC6	2.55e-03	12	119	2	PF01826
Domain	ZU5	ANK3 UNC5D	2.55e-03	12	119	2	PF00791
Domain	ZU5_dom	ANK3 UNC5D	2.55e-03	12	119	2	IPR000906
Domain	Unchr_dom_Cys-rich	MUC5AC MUC6	3.00e-03	13	119	2	IPR014853
Domain	C8	MUC5AC MUC6	3.00e-03	13	119	2	SM00832
Domain	Armadillo	ARMC8 KPNA1 ARMC6	3.33e-03	47	119	3	IPR000225
Domain	-	SELE CLEC18A CLEC18B CLEC18C	3.44e-03	97	119	4	3.10.100.10
Domain	PLAC	ADAMTSL1 ADAMTSL3	3.48e-03	14	119	2	PF08686
Domain	TUDOR	TDRD7 TDRD6	3.48e-03	14	119	2	PF00567
Domain	C-type_lectin-like/link	SELE CLEC18A CLEC18B CLEC18C	3.70e-03	99	119	4	IPR016186
Domain	VWF_type-D	MUC5AC MUC6	4.56e-03	16	119	2	IPR001846
Domain	VWFD	MUC5AC MUC6	4.56e-03	16	119	2	PS51233
Domain	VWD	MUC5AC MUC6	4.56e-03	16	119	2	SM00216
Domain	VWD	MUC5AC MUC6	4.56e-03	16	119	2	PF00094
Domain	CTDL_fold	SELE CLEC18A CLEC18B CLEC18C	4.88e-03	107	119	4	IPR016187
Domain	KAP	KRTAP10-7 KRTAP10-6 KRTAP10-12	6.03e-03	58	119	3	IPR002494
Domain	ARM-type_fold	RTTN INTS1 ITPR2 ATM ARMC8 KPNA1 ARMC6	6.04e-03	339	119	7	IPR016024
Pathway	REACTOME_METABOLISM_OF_FAT_SOLUBLE_VITAMINS	GPC1 LDLR LRP1 LRP2 AGRN	1.05e-05	48	86	5	M27642
Pathway	REACTOME_DISEASES_OF_GLYCOSYLATION	GPC1 ADAMTSL1 ADAMTSL3 ADAMTS12 MUC5AC AGRN MUC6	2.63e-05	143	86	7	M27275
Pathway	REACTOME_DISEASES_ASSOCIATED_WITH_O_GLYCOSYLATION_OF_PROTEINS	ADAMTSL1 ADAMTSL3 ADAMTS12 MUC5AC MUC6	5.79e-05	68	86	5	M27303
Pathway	BIOCARTA_SPRY_PATHWAY	SPRY1 EGF EGFR	1.16e-04	16	86	3	MM1500
Pathway	BIOCARTA_SPRY_PATHWAY	SPRY1 EGF EGFR	1.40e-04	17	86	3	M1389
Pathway	REACTOME_METABOLISM_OF_FAT_SOLUBLE_VITAMINS	GPC1 LRP1 LRP2 AGRN	1.59e-04	45	86	4	MM15344
Pathway	WP_RETINOBLASTOMA_GENE_IN_CANCER	CDKN1A POLA1 FAF1 ORC1 PRIM1	2.20e-04	90	86	5	M39678
Pathway	WP_COMPLEMENT_SYSTEM	SELE LRP2 PLAUR ALB C9	2.97e-04	96	86	5	M39581
Pathway	REACTOME_E2F_MEDIATED_REGULATION_OF_DNA_REPLICATION	POLA1 ORC1 PRIM1	3.10e-04	22	86	3	M6768
Pathway	REACTOME_DNA_REPLICATION_PRE_INITIATION	POLA1 PSMB10 ORC1 PRIM1 KPNA1	3.12e-04	97	86	5	MM15369
Pathway	REACTOME_RESPIRATORY_SYNCYTIAL_VIRUS_RSV_ATTACHMENT_AND_ENTRY	GPC1 EGFR AGRN	3.55e-04	23	86	3	M48234
Pathway	REACTOME_VISUAL_PHOTOTRANSDUCTION	GPC1 LDLR LRP1 LRP2 AGRN	3.59e-04	100	86	5	M27158
Pathway	BIOCARTA_ERBB3_PATHWAY	EGF EGFR	3.64e-04	5	86	2	M22018
Pathway	REACTOME_G1_S_TRANSITION	CDKN1A POLA1 PSMB10 ORC1 PRIM1	4.30e-04	104	86	5	MM15376
Pathway	WP_G1_TO_S_CELL_CYCLE_CONTROL	CDKN1A ORC1 PRIM1 ATM	5.17e-04	61	86	4	MM15912
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	ADAMTSL1 ADAMTSL3 ADAMTS12 MUC5AC MUC6	5.34e-04	109	86	5	MM15164
Pathway	BIOCARTA_EEA1_PATHWAY	EGF EGFR	5.43e-04	6	86	2	MM1577
Pathway	BIOCARTA_ERBB3_PATHWAY	EGF EGFR	5.43e-04	6	86	2	MM1543
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	ADAMTSL1 ADAMTSL3 ADAMTS12 MUC5AC MUC6	5.80e-04	111	86	5	M27416
Pathway	WP_G1_TO_S_CELL_CYCLE_CONTROL	CDKN1A ORC1 PRIM1 ATM	6.21e-04	64	86	4	M39627
Pathway	BIOCARTA_EEA1_PATHWAY	EGF EGFR	7.57e-04	7	86	2	M22064
Pathway	KEGG_MEDICUS_REFERENCE_EGF_JAK_STAT_SIGNALING_PATHWAY	EGF EGFR	7.57e-04	7	86	2	M47430
Pathway	KEGG_MEDICUS_VARIANT_ERBB2_OVEREXPRESSION_TO_EGF_JAK_STAT_SIGNALING_PATHWAY	EGF EGFR	7.57e-04	7	86	2	M47431
Pathway	REACTOME_DISEASES_OF_METABOLISM	GPC1 ADAMTSL1 ADAMTSL3 ADAMTS12 MUC5AC AGRN MUC6	8.28e-04	250	86	7	M27554
Pathway	REACTOME_DEVELOPMENTAL_BIOLOGY	GPC1 CDKN1A CACNA1S KRT78 ANK3 RBBP5 RPS2 PSMB10 ITGA8 ACVR1B KRTAP10-7 KRTAP10-6 KRTAP10-12 TYRP1 EGF EGFR HES1 AGRN UNC5D	8.53e-04	1432	86	19	M509
Pathway	REACTOME_EGFR_DOWNREGULATION	SPRY1 EGF EGFR	8.71e-04	31	86	3	MM14705
Pathway	REACTOME_EGFR_DOWNREGULATION	SPRY1 EGF EGFR	8.71e-04	31	86	3	M16597
Pathway	REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX	POLA1 ORC1 PRIM1	9.57e-04	32	86	3	MM15368
Pathway	REACTOME_DNA_REPLICATION	POLA1 PSMB10 ORC1 PRIM1 KPNA1	9.93e-04	125	86	5	MM15380
Pathway	REACTOME_DNA_REPLICATION_INITIATION	POLA1 PRIM1	1.01e-03	8	86	2	MM15367
Pathway	REACTOME_DNA_REPLICATION_INITIATION	POLA1 PRIM1	1.01e-03	8	86	2	M27664
Pathway	KEGG_MEDICUS_VARIANT_EGF_OVEREXPRESSION_TO_PI3K_SIGNALING_PATHWAY	EGF EGFR	1.01e-03	8	86	2	M47498
Pathway	PID_E2F_PATHWAY	CDKN1A POLA1 ORC1 ATM	1.02e-03	73	86	4	M40
Pathway	REACTOME_ACTIVATION_OF_THE_PRE_REPLICATIVE_COMPLEX	POLA1 ORC1 PRIM1	1.05e-03	33	86	3	M9694
Pathway	REACTOME_MITOTIC_G1_PHASE_AND_G1_S_TRANSITION	CDKN1A POLA1 PSMB10 ORC1 PRIM1	1.18e-03	130	86	5	MM15146
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_PI3K_SIGNALING_PATHWAY	EGF EGFR	1.29e-03	9	86	2	M47392
Pathway	KEGG_MEDICUS_REFERENCE_ATR_P21_CELL_CYCLE_G2_M	CDKN1A ATM	1.29e-03	9	86	2	M47586
Pathway	REACTOME_EGFR_INTERACTS_WITH_PHOSPHOLIPASE_C_GAMMA	EGF EGFR	1.29e-03	9	86	2	M27133
Pathway	REACTOME_ASSEMBLY_OF_THE_ORC_COMPLEX_AT_THE_ORIGIN_OF_REPLICATION	ORC1 KPNA1	1.29e-03	9	86	2	MM15358
Pathway	REACTOME_EGFR_INTERACTS_WITH_PHOSPHOLIPASE_C_GAMMA	EGF EGFR	1.29e-03	9	86	2	MM14853
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	IPPK RBBP5 POLA1 INTS1 OBSCN UNC93A ACVR1B BIRC6 ITPR2 RPS6KC1 IVNS1ABP DQX1 TLR3 LRP2 ALB ATM LONRF2 BANK1	1.50e-10	736	124	18	29676528
Pubmed	Cigarette smoke augments MUC5AC production via the TLR3-EGFR pathway in airway epithelial cells.	EGFR TLR3 MUC5AC	4.42e-08	3	124	3	26100173
Pubmed	The C-type lectin-like domain superfamily.	CLEC18A CLEC18B CLEC18C	4.42e-08	3	124	3	16336259
Pubmed	Endosomal TLR3 co-receptor CLEC18A enhances host immune response to viral infection.	CLEC18A CLEC18B CLEC18C	4.42e-08	3	124	3	33603190
Pubmed	Human CLEC18 Gene Cluster Contains C-type Lectins with Differential Glycan-binding Specificity.	CLEC18A CLEC18B CLEC18C	4.42e-08	3	124	3	26170455
Pubmed	Rhinovirus-induced major airway mucin production involves a novel TLR3-EGFR-dependent pathway.	EGFR TLR3 MUC5AC	4.42e-08	3	124	3	18978302
Pubmed	The mannose receptor mediates uptake of soluble but not of cell-associated antigen for cross-presentation.	CLEC18A CLEC18B CLEC18C	1.76e-07	4	124	3	16709836
Pubmed	Comparison of the gene expression profiles from normal and Fgfrl1 deficient mouse kidneys reveals downstream targets of Fgfrl1 signaling.	CLEC18A SPRY1 CLEC18B ITGA8 CLEC18C	2.11e-07	37	124	5	22432025
Pubmed	Interaction of the apolipoprotein E receptors low density lipoprotein receptor-related protein and sorLA/LR11.	LRP1 LRP2 SORL1	4.40e-07	5	124	3	19047013
Pubmed	Interaction of coagulation factor VIII with members of the low-density lipoprotein receptor family follows common mechanism and involves consensus residues within the A2 binding site 484-509.	LDLR LRP1 LRP2	4.40e-07	5	124	3	18685438
Pubmed	Interaction of cytosolic adaptor proteins with neuronal apolipoprotein E receptors and the amyloid precursor protein.	LDLR LRP1 LRP2	8.78e-07	6	124	3	9837937
Pubmed	Colocalization of transforming growth factor-alpha and a functional epidermal growth factor receptor (EGFR) to the inner cell mass and preferential localization of the EGFR on the basolateral surface of the trophectoderm in the mouse blastocyst.	EGF EGFR CTSB	8.78e-07	6	124	3	1426645
Pubmed	hSpry2 is targeted to the ubiquitin-dependent proteasome pathway by c-Cbl.	SPRY1 EGF EGFR	8.78e-07	6	124	3	12593796
Pubmed	MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.	LRP1B LDLR LRP1 LRP2	8.79e-07	21	124	4	21337463
Pubmed	Characterization of 458 single nucleotide polymorphisms of disease candidate genes in the Korean population.	SELE EGF EGFR LRP2	1.07e-06	22	124	4	12768436
Pubmed	Embryo implantation in mouse: fetomaternal coordination in the pattern of expression of uPA, uPAR, PAI-1 and alpha 2MR/LRP genes.	LDLR LRP1 PLAUR	1.53e-06	7	124	3	8798151
Pubmed	The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor.	LDLR LRP1 LRP2	1.53e-06	7	124	3	12169628
Pubmed	Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.	LRP1B LDLR ITPR2 EGFR LRP1 LRP2	1.75e-06	101	124	6	23382219
Pubmed	Epidermal growth factor receptor regulates beta-catenin location, stability, and transcriptional activity in oral cancer.	CDKN1A EGF EGFR	2.45e-06	8	124	3	20302655
Pubmed	Olfactory receptor 2 in vascular macrophages drives atherosclerosis by NLRP3-dependent IL-1 production.	RTP1 RTP2 LDLR	2.45e-06	8	124	3	35025664
Pubmed	Stabilization of beta-catenin affects mouse embryonic liver growth and hepatoblast fate.	CDKN1A ONECUT2 CPS1 ALB	3.41e-06	29	124	4	18038450
Pubmed	Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance.	LDLR LRP1 SORL1	3.66e-06	9	124	3	20005821
Pubmed	Local anesthetics impair the growth and self-renewal of glioblastoma stem cells by inhibiting ZDHHC15-mediated GP130 palmitoylation.	ACVR1B LRP1 LRP2 MUC5AC MUC6	5.73e-06	71	124	5	33541421
Pubmed	A mouse knockout library for secreted and transmembrane proteins.	CLEC18A ADAMTSL1 CLEC18B TMEM50A INTS1 CLEC18C ADAMTS12 TLR3 ALB LGR6	6.33e-06	460	124	10	20562862
Pubmed	Sprouty2 acts at the Cbl/CIN85 interface to inhibit epidermal growth factor receptor downregulation.	SPRY1 EGF EGFR	7.15e-06	11	124	3	15962011
Pubmed	LRP2 mediates folate uptake in the developing neural tube.	LRP1B LRP1 LRP2	7.15e-06	11	124	3	24639464
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	RHBDF2 RTTN INTS1 OBSCN PSMB10 RHOT2 BIRC6 LDLR ITPR2 PPP1R26 ORC1 ZNF263 HERC1 AGRN PRRT4	9.74e-06	1105	124	15	35748872
Pubmed	High glucose promotes pancreatic cancer cell proliferation via the induction of EGF expression and transactivation of EGFR.	EGF EGFR	1.26e-05	2	124	2	22087246
Pubmed	Striking differences of LDL receptor-related protein 1B expression in mouse and human.	LRP1B LRP1	1.26e-05	2	124	2	15963947
Pubmed	Macrophage ABCA5 deficiency influences cellular cholesterol efflux and increases susceptibility to atherosclerosis in female LDLr knockout mice.	LDLR ABCA5	1.26e-05	2	124	2	20382126
Pubmed	Cathepsin B and uPAR regulate self-renewal of glioma-initiating cells through GLI-regulated Sox2 and Bmi1 expression.	PLAUR CTSB	1.26e-05	2	124	2	23222817
Pubmed	Ontogenesis and distribution of epidermal growth factor immunoreactivity and binding activity in the mouse fetal and neonatal tissues.	EGF EGFR	1.26e-05	2	124	2	7951532
Pubmed	Low density lipoprotein receptor-related protein polymorphisms are not risk factors for venous thromboembolism.	LDLR LRP1	1.26e-05	2	124	2	17889283
Pubmed	The role of PRMT1 in EGFR methylation and signaling in MDA-MB-468 triple-negative breast cancer cells.	EGFR PRMT1	1.26e-05	2	124	2	28643125
Pubmed	Increased expression of mucin 5AC mRNA and decreased expression of epidermal growth-factor receptor mRNA in gallstone patients.	EGFR MUC5AC	1.26e-05	2	124	2	18285671
Pubmed	Hepatic Overexpression of Soluble Urokinase Receptor (uPAR) Suppresses Diet-Induced Atherosclerosis in Low-Density Lipoprotein Receptor-Deficient (LDLR-/-) Mice.	LDLR PLAUR	1.26e-05	2	124	2	26313756
Pubmed	The soluble form of LR11 protein is a regulator of hypoxia-induced, urokinase-type plasminogen activator receptor (uPAR)-mediated adhesion of immature hematological cells.	PLAUR SORL1	1.26e-05	2	124	2	23486467
Pubmed	The role of EGF-EGFR signalling pathway in hepatocellular carcinoma inflammatory microenvironment.	EGF EGFR	1.26e-05	2	124	2	24268047
Pubmed	Upregulation of hepatic LDL transport by n-3 fatty acids in LDL receptor knockout mice.	LDLR LRP1	1.26e-05	2	124	2	11971949
Pubmed	FRET detects lateral interaction between transmembrane domain of EGF receptor and ganglioside GM3 in lipid bilayers.	EGF EGFR	1.26e-05	2	124	2	33933428
Pubmed	pH dependence of ligand-induced human epidermal growth factor receptor activation investigated by molecular dynamics simulations.	EGF EGFR	1.26e-05	2	124	2	27179806
Pubmed	Epigenetic role of epidermal growth factor expression and signalling in embryonic mouse lung morphogenesis.	EGF EGFR	1.26e-05	2	124	2	1728582
Pubmed	Human adult epidermal melanocytes cultured without chemical mitogens express the EGF receptor and respond to EGF.	EGF EGFR	1.26e-05	2	124	2	17334773
Pubmed	Megalin/gp330 mediates uptake of albumin in renal proximal tubule.	LRP2 ALB	1.26e-05	2	124	2	8898021
Pubmed	Determining the geometry of oligomers of the human epidermal growth factor family on cells with <10 nm resolution.	EGF EGFR	1.26e-05	2	124	2	26009168
Pubmed	Epidermal growth factor as a biologic switch in hair growth cycle.	EGF EGFR	1.26e-05	2	124	2	12714603
Pubmed	Receptor-transporting protein (RTP) family members play divergent roles in the functional expression of odorant receptors.	RTP1 RTP2	1.26e-05	2	124	2	28586385
Pubmed	LRP: role in vascular wall integrity and protection from atherosclerosis.	LDLR LRP1	1.26e-05	2	124	2	12690199
Pubmed	Clinical significance of EGF and EGFR expression changes in cryptorchid boys.	EGF EGFR	1.26e-05	2	124	2	12508124
Pubmed	Role of N-glycosylation in EGFR ectodomain ligand binding.	EGF EGFR	1.26e-05	2	124	2	28486782
Pubmed	Cell Force-Driven Basement Membrane Disruption Fuels EGF- and Stiffness-Induced Invasive Cell Dissemination from Benign Breast Gland Acini.	EGF EGFR	1.26e-05	2	124	2	33921304
Pubmed	Heterogeneity in EGF-binding affinities arises from negative cooperativity in an aggregating system.	EGF EGFR	1.26e-05	2	124	2	18165319
Pubmed	EGF abrogation-induced fusilli-form dysmorphogenesis of Meckel's cartilage during embryonic mouse mandibular morphogenesis in vitro.	EGF EGFR	1.26e-05	2	124	2	8076525
Pubmed	Gastric MUC5AC and MUC6 are large oligomeric mucins that differ in size, glycosylation and tissue distribution.	MUC5AC MUC6	1.26e-05	2	124	2	11988092
Pubmed	Activation of ATM signaling pathway is involved in oxidative stress-induced expression of mito-inhibitory p21WAF1/Cip1 in chronic non-suppurative destructive cholangitis in primary biliary cirrhosis: an immunohistochemical study.	CDKN1A ATM	1.26e-05	2	124	2	18456456
Pubmed	Epidermal growth factor mutant with wild-type affinity for both ErbB1 and ErbB3.	EGF EGFR	1.26e-05	2	124	2	16584205
Pubmed	Potent SHC tyrosine phosphorylation by epidermal growth factor at low receptor density or in the absence of receptor autophosphorylation sites.	EGF EGFR	1.26e-05	2	124	2	8036006
Pubmed	Deficiency of inactive rhomboid protein 2 (iRhom2) attenuates diet-induced hyperlipidaemia and early atherogenesis.	RHBDF2 LDLR	1.26e-05	2	124	2	33576385
Pubmed	LRP1 regulates remodeling of the extracellular matrix by fibroblasts.	LRP1 PLAUR	1.26e-05	2	124	2	19699300
Pubmed	Endocytic Protein Defects in the Neural Crest Cell Lineage and Its Pathway Are Associated with Congenital Heart Defects.	LRP1 LRP2	1.26e-05	2	124	2	34445520
Pubmed	The epidermal growth factor.	EGF EGFR	1.26e-05	2	124	2	7640657
Pubmed	Detection of epidermal growth factor-urogastrone and its receptor during fetal mouse development.	EGF EGFR	1.26e-05	2	124	2	6248866
Pubmed	Global defects in the expression and function of the low density lipoprotein receptor (LDLR) associated with two familial hypercholesterolemia mutations resulting in misfolding of the LDLR epidermal growth factor-AB pair.	LDLR EGFR	1.26e-05	2	124	2	15100232
Pubmed	Translocation of Epidermal Growth Factor (EGF) to the nucleus has distinct kinetics between adipose tissue-derived mesenchymal stem cells and a mesenchymal cancer cell lineage.	EGF EGFR	1.26e-05	2	124	2	29277356
Pubmed	Soluble Urokinase Receptor Is Released Selectively by Glioblastoma Cells That Express Epidermal Growth Factor Receptor Variant III and Promotes Tumor Cell Migration and Invasion.	EGFR PLAUR	1.26e-05	2	124	2	25837250
Pubmed	Heterodimerization of the epidermal-growth-factor (EGF) receptor and ErbB2 and the affinity of EGF binding are regulated by different mechanisms.	EGF EGFR	1.26e-05	2	124	2	11336639
Pubmed	The survival outcomes of patients with resected non-small cell lung cancer differ according to EGFR mutations and the P21 expression.	CDKN1A EGFR	1.26e-05	2	124	2	17337084
Pubmed	Human mucin genes MUC2, MUC3, MUC4, MUC5AC, MUC5B, and MUC6 express stable and extremely large mRNAs and exhibit a variable length polymorphism. An improved method to analyze large mRNAs.	MUC5AC MUC6	1.26e-05	2	124	2	9422745
Pubmed	Association between epidermal growth factor (EGF) and EGF receptor gene polymorphisms and end-stage renal disease and acute renal allograft rejection in a Korean population.	EGF EGFR	1.26e-05	2	124	2	31906817
Pubmed	Simultaneous human papilloma virus type 16 E7 and cdk inhibitor p21 expression induces apoptosis and cathepsin B activation.	CDKN1A CTSB	1.26e-05	2	124	2	15016552
Pubmed	Complex relationship between ligand binding and dimerization in the epidermal growth factor receptor.	EGF EGFR	1.26e-05	2	124	2	25453753
Pubmed	Aberrant expression of MUC5AC and MUC6 gastric mucins and sialyl Tn antigen in intraepithelial neoplasms of the pancreas.	MUC5AC MUC6	1.26e-05	2	124	2	12360467
Pubmed	[Expression of epidermal growth factor receptor and concentrations of epidermal growth factor and melatonin in endometrial carcinoma].	EGF EGFR	1.26e-05	2	124	2	25416211
Pubmed	Amplification of the EGFR gene can be maintained and modulated by variation of EGF concentrations in in vitro models of glioblastoma multiforme.	EGF EGFR	1.26e-05	2	124	2	28934307
Pubmed	ATM and p21 cooperate to suppress aneuploidy and subsequent tumor development.	CDKN1A ATM	1.26e-05	2	124	2	16204044
Pubmed	MUC5AC, a gel-forming mucin accumulating in gallstone disease, is overproduced via an epidermal growth factor receptor pathway in the human gallbladder.	EGFR MUC5AC	1.26e-05	2	124	2	17148666
Pubmed	An extrahepatic receptor-associated protein-sensitive mechanism is involved in the metabolism of triglyceride-rich lipoproteins.	LDLR LRP1	1.26e-05	2	124	2	10575007
Pubmed	Effect of epidermal growth factor administration on the development of mouse salivary gland carcinomas.	EGF EGFR	1.26e-05	2	124	2	9890455
Pubmed	Small tandem DNA duplications result from CST-guided Pol α-primase action at DNA break termini.	POLA1 PRIM1	1.26e-05	2	124	2	34376693
Pubmed	Role of epidermal growth factor and its receptor in chemotherapy-induced intestinal injury.	EGF EGFR	1.26e-05	2	124	2	11841993
Pubmed	Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor.	EGF EGFR	1.26e-05	2	124	2	21822280
Pubmed	Safe and Effective Sarcoma Therapy through Bispecific Targeting of EGFR and uPAR.	EGFR PLAUR	1.26e-05	2	124	2	28193671
Pubmed	Proteome mapping of epidermal growth factor induced hepatocellular carcinomas identifies novel cell metabolism targets and mitogen activated protein kinase signalling events.	EGF EGFR	1.26e-05	2	124	2	25872475
Pubmed	EGF/EGFR axis contributes to the progression of cholangiocarcinoma through the induction of an epithelial-mesenchymal transition.	EGF EGFR	1.26e-05	2	124	2	24704591
Pubmed	LDL-receptor mRNA expression in men is downregulated within an hour of an acute fat load and is influenced by genetic polymorphism.	LDLR LRP1	1.26e-05	2	124	2	17709443
Pubmed	EGF/EGFR Promotes Salivary Adenoid Cystic Carcinoma Cell Malignant Neural Invasion via Activation of PI3K/AKT and MEK/ERK Signaling.	EGF EGFR	1.26e-05	2	124	2	35410600
Pubmed	EGFR genomic gain and aberrant pathway signaling in pancreatic cancer patients.	EGF EGFR	1.26e-05	2	124	2	17950068
Pubmed	Modulation of focal adhesion constituents and their down-stream events by EGF: On the cross-talk of integrins and growth factor receptors.	EGF EGFR	1.26e-05	2	124	2	26079101
Pubmed	Human cytomegalovirus infection inhibits epidermal growth factor (EGF) signalling by targeting EGF receptors.	EGF EGFR	1.26e-05	2	124	2	12388817
Pubmed	SCGB1C1 Plays a Critical Role in Suppression of Allergic Airway Inflammation through the Induction of Regulatory T Cell Expansion.	SCGB1C2 SCGB1C1	1.26e-05	2	124	2	38892470
Pubmed	Rhinovirus induces MUC5AC in a human infection model and in vitro via NF-κB and EGFR pathways.	EGFR MUC5AC	1.26e-05	2	124	2	20525715
Pubmed	Cholesterol levels modulate EGF receptor-mediated signaling by altering receptor function and trafficking.	EGF EGFR	1.26e-05	2	124	2	12162747
Pubmed	Tudor domain containing 7 (Tdrd7) is essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis.	TDRD7 TDRD6	1.26e-05	2	124	2	21670278
Pubmed	Conformational stability of the epidermal growth factor (EGF) receptor as influenced by glycosylation, dimerization and EGF hormone binding.	EGF EGFR	1.26e-05	2	124	2	28019699
Pubmed	EGFR/uPAR interaction as druggable target to overcome vemurafenib acquired resistance in melanoma cells.	EGFR PLAUR	1.26e-05	2	124	2	30611716
Pubmed	Loss of p21 increases sensitivity to ionizing radiation and delays the onset of lymphoma in atm-deficient mice.	CDKN1A ATM	1.26e-05	2	124	2	9405657
Pubmed	Clinicopathological features of superficial non-ampurally duodenal epithelial tumor; gastric phenotype of histology correlates to higher malignant potency.	MUC5AC MUC6	1.26e-05	2	124	2	28321513
Pubmed	EGF ligand fused to truncated Pseudomonas aeruginosa exotoxin A specifically targets and inhibits EGFR‑positive cancer cells.	EGF EGFR	1.26e-05	2	124	2	30226622
Pubmed	Epidermal Growth Factor Removal or Tyrphostin AG1478 Treatment Reduces Goblet Cells & Mucus Secretion of Epithelial Cells from Asthmatic Children Using the Air-Liquid Interface Model.	EGF MUC5AC	1.26e-05	2	124	2	26057128
Pubmed	The +61 A-G polymorphism of the epidermal growth factor gene is not associated with occurrence of non-melanocytic skin tumors in transplant recipients.	EGF EGFR	1.26e-05	2	124	2	17223314
Interaction	ZFP41 interactions	LRP1B LDLR KRTAP10-7 LRP1 LRP2 AGRN SORL1	5.15e-08	57	122	7	int:ZFP41
Interaction	ZNF563 interactions	LRP1B KRTAP10-6 HERC1 SORL1	6.09e-07	12	122	4	int:ZNF563
Interaction	NR4A1 interactions	CPT1A PPBP HNRNPH2 FAF1 PIAS3 ABCA5 ANKIB1 HES1 ATM KPNA1	6.64e-07	212	122	10	int:NR4A1
Interaction	RNF123 interactions	IPPK RBBP5 POLA1 INTS1 OBSCN UNC93A ACVR1B BIRC6 ITPR2 RPS6KC1 IVNS1ABP DQX1 TLR3 LRP2 ALB ATM LONRF2 BANK1	2.33e-06	824	122	18	int:RNF123
Interaction	EGFL6 interactions	LRP1B LDLR LRP2 SORL1	7.06e-06	21	122	4	int:EGFL6
Interaction	APOE interactions	LDLR LRP1 LRP2 ALB C9 CTSB AGRN SORL1	9.66e-06	171	122	8	int:APOE
Interaction	NTN5 interactions	LRP1B LDLR LRP2 SORL1	1.24e-05	24	122	4	int:NTN5
Interaction	TAFA4 interactions	ITGA8 PTPRU ITPR2 LRP2 SORL1	2.04e-05	55	122	5	int:TAFA4
Interaction	EXT1 interactions	LDLR SCGB2A1 EGFR PLAUR SCGB1C1	2.44e-05	57	122	5	int:EXT1
Interaction	VHL interactions	CDKN1A RPS2 KDM5C RB1CC1 BIRC6 HNRNPH2 TDRD7 IVNS1ABP MEX3A EGFR DGKI PRMT1 ATM	3.61e-05	561	122	13	int:VHL
Interaction	ADGRG2 interactions	INTS1 GMIP ATM	4.58e-05	12	122	3	int:ADGRG2
Interaction	IGFL3 interactions	LRP1B LDLR LRP2 AGRN SORL1	9.21e-05	75	122	5	int:IGFL3
Interaction	CUBN interactions	LRP1 LRP2 ALB	9.34e-05	15	122	3	int:CUBN
Interaction	CCN2 interactions	MEX3A EGFR LRP1 LRP2	9.87e-05	40	122	4	int:CCN2
Interaction	ZNF264 interactions	KRTAP10-7 KRTAP10-6 LRP2 SORL1	1.09e-04	41	122	4	int:ZNF264
Interaction	TAFA3 interactions	BIRC6 LRP1B LDLR LRP2 SORL1	1.11e-04	78	122	5	int:TAFA3
Interaction	LRPAP1 interactions	GMIP LRP1B LDLR LRP1 LRP2 CTSB SORL1	1.14e-04	180	122	7	int:LRPAP1
Interaction	DEFB123 interactions	LRP1B LDLR SORL1	1.14e-04	16	122	3	int:DEFB123
Cytoband	21q22.3	KRTAP10-7 KRTAP10-6 KRTAP10-12 TRAPPC10	4.18e-04	128	124	4	21q22.3
Cytoband	6q25	SYNE1 ULBP3	4.69e-04	12	124	2	6q25
GeneFamily	Low density lipoprotein receptors	LRP1B LDLR LRP1 LRP2	4.73e-07	13	94	4	634
GeneFamily	Secretoglobins	SCGB2A1 SCGB1C2 SCGB1C1	4.75e-05	14	94	3	734
GeneFamily	Zinc fingers 3CxxC-type\|Receptor transporter proteins	RTP1 RTP2	2.65e-04	5	94	2	719
GeneFamily	ADAMTS like	ADAMTSL1 ADAMTSL3	5.52e-04	7	94	2	947
GeneFamily	Type 1 receptor serine/threonine kinases	ACVR1B BMPR1B	5.52e-04	7	94	2	345
GeneFamily	Zinc fingers 3CxxC-type\|Receptor transporter proteins	RTP1 RTP2	7.34e-04	8	94	2	137
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	ARMC8 KPNA1 ARMC6	1.44e-03	43	94	3	409
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	ADAMTSL1 OBSCN ADAMTSL3 WFIKKN2 UNC5D	1.53e-03	161	94	5	593
GeneFamily	C-type lectin domain family	CLEC18A CLEC18B CLEC18C	1.87e-03	47	94	3	494
GeneFamily	CD molecules\|Mucins	MUC5AC MUC6	5.27e-03	21	94	2	648
ToppCell	(9)_Platelet\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	PPBP TSPAN9 EGF SCGB1C2 DGKI SEC14L5 SCGB1C1	6.62e-07	177	124	7	0830944c43de300815831a9e2b2fce40965e7d12
ToppCell	(9)_Platelet\|World / Spleen cell shreds - cell class (v1) and cell subclass (v1)	PPBP TSPAN9 EGF SCGB1C2 DGKI SEC14L5 SCGB1C1	6.62e-07	177	124	7	e63d01c7fce4fa1256212fa7e95f74281edb3a01
ToppCell	megakaryocytic-Platelet\|World / Lineage and Cell class	PPBP TSPAN9 EGF SCGB1C2 MYEOV SEC14L5 SCGB1C1	7.41e-07	180	124	7	c007c3e63c2bb35ed34327dd8863899b5db93115
ToppCell	PBMC-Control-Hematopoietic-Platelet-Platelet-plt_3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	PPBP TSPAN9 EGF SCGB1C2 MYEOV SEC14L5 SCGB1C1	8.58e-07	184	124	7	a5d904dd030d9c21be0f8b9ec432025f90fb5b8e
ToppCell	PBMC-Control-Hematopoietic-Platelet-Platelet-plt_3\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PPBP TSPAN9 EGF SCGB1C2 MYEOV SEC14L5 SCGB1C1	8.58e-07	184	124	7	7617a00b2ebd6c5c9386c39a7e8220fdbf8669ff
ToppCell	PBMC-Control-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	CDKN1A ACVR1B LDLR LRP1 HES1 PLAUR CTSB	1.14e-06	192	124	7	f14ee74ac3275601749a23c5efe39c2413a62e1a
ToppCell	PBMC-Control-Myeloid-Classical_Monocyte-Classical_Monocyte-cMono_4\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	CDKN1A ACVR1B LDLR LRP1 HES1 PLAUR CTSB	1.14e-06	192	124	7	0219093e7921a0db78053aee13ec480b520f5662
ToppCell	NS-control-d_0-4-Epithelial-Secretory\|d_0-4 / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	GPC1 CARMIL1 IVNS1ABP FAT2 ZNHIT6 EGFR SORL1	1.45e-06	199	124	7	32bdfff40fd442b88489c8b0f79af3927a51a03c
ToppCell	control-Epithelial-Secretory\|control / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	GPC1 CARMIL1 IVNS1ABP FAT2 ZNHIT6 EGFR SORL1	1.45e-06	199	124	7	262e5b8a52c8ddb0b47048c786e8bdb7158e1b9a
ToppCell	Neuronal\|World / cells hierarchy compared to all cells using T-Statistic	ANK3 SYNE1 ABCA5 SNTG1 DGKI HERC1 UNC5D	1.50e-06	200	124	7	48d801219bc771d6c7e151dc88ca4c179988de85
ToppCell	367C-Myeloid-Macrophage-FABP4+_Macrophage_3\|367C / Donor, Lineage, Cell class and subclass (all cells)	ZNF383 ZNF829 BAALC-AS2 RPS6KC1 BMPR1B PRRT4	1.83e-06	131	124	6	aeeb5718b3a7122492ad2659d5c8112f60839ff3
ToppCell	Thalamus-Neuronal-Excitatory-eN2(Slc17a7_Slc17a6)-Slc17a7-Tac2-Excitatory_Neuron.Slc17a7.Tac2.Chat_(Habenular_cholinergic_cells)\|Thalamus / BrainAtlas - Mouse McCarroll V32	CLEC18A OBSCN TYRP1 WFIKKN2 TDRD6	3.38e-06	82	124	5	51dd9ab3ddb26d3d3395d0c1a156a12a86caf89b
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Rln3_(parabrachial_pigmented_nucleus_(PBP))-\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	RTP2 LRRC43 FAT2 DQX1 ZNF471	4.78e-06	88	124	5	b4620e79ea80681305434707e87cb02a7c6a5e4f
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Rln3_(parabrachial_pigmented_nucleus_(PBP))--\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	RTP2 LRRC43 FAT2 DQX1 ZNF471	4.78e-06	88	124	5	7992f8e621edf464bffcb70a6cc5f3b60c1d96f8
ToppCell	Substantia_nigra-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Rln3_(parabrachial_pigmented_nucleus_(PBP))\|Substantia_nigra / BrainAtlas - Mouse McCarroll V32	RTP2 LRRC43 FAT2 DQX1 ZNF471	4.78e-06	88	124	5	b7b55f51af8ffa82813a4747580985a430da9ed1
ToppCell	facs-Marrow-Granulocytes-18m-Hematologic\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ONECUT2 CACNA1S ITGA8 TENT5C LRP1 AGRN	6.03e-06	161	124	6	60f433eab9d5531bdf6aa86b0265f20b866b904c
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	UNC93A CPS1 LRP1B ABCA5 LGR6 UNC5D	6.24e-06	162	124	6	bf886e22ff2a20353499004b53f25fb9e6574896
ToppCell	PBMC-Mild-Hematopoietic-Platelet-Platelet-plt_0\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	PPBP TSPAN9 EGF DGKI SEC14L5 SCGB1C1	6.94e-06	165	124	6	6799a6580c667738995cceb31cbf1c7fbdc4ff84
ToppCell	PBMC-Mild-Hematopoietic-Platelet-Platelet-plt_0\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PPBP TSPAN9 EGF DGKI SEC14L5 SCGB1C1	6.94e-06	165	124	6	8329d780f244bc31344443b29e5a00529a016662
ToppCell	Control\|World / group, cell type (main and fine annotations)	ANK3 SYNE1 LDLR EGFR LRP2 MUC5AC	7.69e-06	168	124	6	a3511faf2cd2c2b9c8363c8b99da3f3609c43ed6
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	VWA3A MDFIC ADAMTSL1 ITGA8 PTPRU LGR6	8.23e-06	170	124	6	417b77c12a7982b1ce4b4bc57f30335d261220f5
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-hematologic-thrombocytic\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PPBP TSPAN9 EGF DGKI SEC14L5 SCGB1C1	8.80e-06	172	124	6	1a9b99c7fc297d9e4b6098bf0c4fb98927a05f6d
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-hematologic-thrombocytic-platelet\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	PPBP TSPAN9 EGF DGKI SEC14L5 SCGB1C1	8.80e-06	172	124	6	d588ca825ab301910c1378e009b766c809b0bd5e
ToppCell	5'-Airway_Nasal-Epithelial-Epithelial_transtional-secretory-club_cell-Club_(non-nasal)-Club_(non-nasal)_L.0.4.0.0\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	MDFIC ANK3 RBBP5 CPT1A CARD6 MUC5AC	9.39e-06	174	124	6	3f0a5ce074675d57d479fa069385a1b3071e884e
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTSL1 CARMIL1 ADAMTSL3 BMPR1B EGFR DGKI	1.00e-05	176	124	6	6c7edf1cb38644500bce6c5a1dd90bbe17415cdb
ToppCell	IIF-Other-Platelet\|IIF / Disease, Lineage and Cell Type	CDKN1A PPBP TSPAN9 EGF SCGB1C2 SCGB1C1	1.07e-05	178	124	6	529c0d2159e539546876246122f2e999170a6b20
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTSL1 ADAMTSL3 BMPR1B EGFR ABCA5 DGKI	1.07e-05	178	124	6	51d2188406f04329311b2efd1108fc36617a860e
ToppCell	3'_v3-blood-Hematopoietic_Erythro-Mega-Megakaryocyte_early\|blood / Manually curated celltypes from each tissue	PPBP TSPAN9 EGF SCGB1C2 MYEOV SEC14L5	1.10e-05	179	124	6	290772eece76d70555dca8b8d82bd88b47e2fc35
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ONECUT2 OBSCN CPS1 LRP1B LRP2 UNC5D	1.29e-05	184	124	6	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ONECUT2 OBSCN CPS1 LRP1B LRP2 UNC5D	1.29e-05	184	124	6	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ONECUT2 OBSCN CPS1 LRP1B LRP2 UNC5D	1.29e-05	184	124	6	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	Fetal_29-31_weeks-Mesenchymal-chondrocyte-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CLEC18A CLEC18B CLEC18C ADAMTSL3 BMPR1B WFIKKN2	1.33e-05	185	124	6	8ed10ba581849c9c4ac4397226be2b62b4b3b900
ToppCell	PBMC-Control-Hematopoietic\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PPBP TSPAN9 EGF SCGB1C2 MYEOV SCGB1C1	1.33e-05	185	124	6	c95c77d4302d7fff7fdef1774f15a93ba9ced61a
ToppCell	PBMC-Control-Hematopoietic\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	PPBP TSPAN9 EGF SCGB1C2 MYEOV SCGB1C1	1.33e-05	185	124	6	72a281ef246de5b30de1241d792c25bfae60e797
ToppCell	Fetal_29-31_weeks-Mesenchymal-chondrocyte\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	CLEC18A CLEC18B CLEC18C ADAMTSL3 BMPR1B WFIKKN2	1.33e-05	185	124	6	b8052cebb73f41abe6faf0aa847be7c8ef23ae94
ToppCell	PBMC-Control-Hematopoietic-Platelet-Platelet\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	PPBP TSPAN9 EGF SCGB1C2 MYEOV SCGB1C1	1.37e-05	186	124	6	3bf38c80d892a73391009b426dec8ae26a027351
ToppCell	PBMC-Control-Hematopoietic-Platelet-Platelet-plt_1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PPBP TSPAN9 EGF SCGB1C2 MYEOV SCGB1C1	1.37e-05	186	124	6	107bc473f5e57238390f8e0ab9f7263a8f93948c
ToppCell	PBMC-Control-Hematopoietic-Platelet\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	PPBP TSPAN9 EGF SCGB1C2 MYEOV SCGB1C1	1.37e-05	186	124	6	7496137cebc191aecd1e6ae7fa33118b128fbfe6
ToppCell	PBMC-Control-Hematopoietic-Platelet\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PPBP TSPAN9 EGF SCGB1C2 MYEOV SCGB1C1	1.37e-05	186	124	6	9c2fd0bbc968c317a763f52e72fa7182c3c49850
ToppCell	PBMC-Control-Hematopoietic-Platelet-Platelet-plt_1\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	PPBP TSPAN9 EGF SCGB1C2 MYEOV SCGB1C1	1.37e-05	186	124	6	13a9ddcf93b0c4319ab9d484af5e2056e9754caa
ToppCell	PBMC-Control-Hematopoietic-Platelet-Platelet\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PPBP TSPAN9 EGF SCGB1C2 MYEOV SCGB1C1	1.37e-05	186	124	6	06281df5e9665ccc510279bf7e552845c63d5dab
ToppCell	kidney_cells-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	CARMIL1 ADAMTSL3 BMPR1B SCGB2A1 DGKI HERC1	1.37e-05	186	124	6	c2b65b8345487710704c3eb043e9bef2e2b1ff27
ToppCell	facs-Lung-EPCAM-3m\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPC1 ANK3 ITGA8 LRP2 SORL1 SCGB1C1	1.37e-05	186	124	6	7c4eb769574f9f32753cea1cc38c711dabba88b9
ToppCell	Control-Hematopoietic_Mega-Platelet\|Control / Disease group, lineage and cell class	PPBP TSPAN9 EGF SCGB1C2 MYEOV SCGB1C1	1.41e-05	187	124	6	53e9665e1feb02ce8fe78ff4128fd4beacef8471
ToppCell	Control-Hematopoietic_Mega\|Control / Disease group, lineage and cell class	PPBP TSPAN9 EGF SCGB1C2 MYEOV SCGB1C1	1.41e-05	187	124	6	7bf98bdc83feb3918dbcf12e87a64fe4d2d41eba
ToppCell	COVID-19-kidney-CD-IC-B\|kidney / Disease (COVID-19 only), tissue and cell type	ADAMTSL1 CARMIL1 ADAMTSL3 BMPR1B EGFR DGKI	1.41e-05	187	124	6	ce05b89860573fe0356102e2998d1ef6d1968034
ToppCell	RA-10._Endothelium_II\|World / Chamber and Cluster_Paper	MDFIC ADAMTSL1 ITGA8 ITPR2 BMPR1B DGKI	1.50e-05	189	124	6	75c248b9de5e2fb7a0baa8cdbab516e575cc4394
ToppCell	RA-10._Endothelium_II\|RA / Chamber and Cluster_Paper	MDFIC ADAMTSL1 ITGA8 ITPR2 BMPR1B DGKI	1.50e-05	189	124	6	c81787a8c662db5d7814c583dd64562857629e81
ToppCell	Healthy-Platelet\|Healthy / disease group, cell group and cell class	PPBP TSPAN9 EGF SCGB1C2 MYEOV SCGB1C1	1.50e-05	189	124	6	5863e132536594e49bffbb637454cc43dfdbaa20
ToppCell	Primary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_C_(IT_L4_RORB)\|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SPRY1 TSPAN9 ITPR2 SNTG1 CCNI SORL1	1.55e-05	190	124	6	1bbbf0ce222e51f9fd2daca0c18d3965fd4efd31
ToppCell	10x5'-lymph-node_spleen-Lymphocytic_T_CD4-T_CD4/CD8\|lymph-node_spleen / Manually curated celltypes from each tissue	ANK3 LDLR IVNS1ABP ATM HERC1 SORL1	1.64e-05	192	124	6	47646d7e4990be85072987f92bf18d52f8da752e
ToppCell	IPF-Epithelial-Basal\|World / Disease state, Lineage and Cell class	GPC1 ANK3 PTPRU BMPR1B FAT2 EGFR	1.64e-05	192	124	6	9b91e0b162e6f3ce86dd15cc33c2e745d069581f
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Degenerative_Outer_Medullary_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ANK3 ADAMTSL3 BMPR1B HES1 AGRN SORL1	1.74e-05	194	124	6	be869e186386d03ebb670971dd24fa656b4b0edf
ToppCell	control-Myeloid-Non-resident_Macrophage\|Myeloid / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	LDLR IVNS1ABP LRP1 PLAUR CTSB SORL1	1.90e-05	197	124	6	df2fe36cb96e2565a9d21c24cb4e451e8befd4be
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	ANK3 SYNE1 RTTN ABCA5 ATM HERC1	2.01e-05	199	124	6	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	LPS_IL1RA-Mesenchymal_myocytic-Myofibroblastic-MatrixFB_->_Myofibroblast\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	SPRY1 ANK3 SYNE1 ADAMTSL3 ADAMTS12 LRP1	2.01e-05	199	124	6	6b3a0e5d52a30d0eed30e6a670f5b53bc233f70c
ToppCell	Control-Control-Others\|Control / Disease, condition lineage and cell class	PPBP TSPAN9 EGF MYEOV SEC14L5 SCGB1C1	2.01e-05	199	124	6	b7e83772fdd466e1bd0ae13af9ac477e7595ae14
ToppCell	control-Epithelial-Secretory\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	CARMIL1 IVNS1ABP FAT2 ZNHIT6 EGFR SORL1	2.01e-05	199	124	6	3d01f90ffd271ca00129192787e4921bdca7e01e
ToppCell	Tracheal-NucSeq-Stromal-Chondrocytic\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CLEC18A CLEC18B SYNE1 CLEC18C LRP1B IVNS1ABP	2.07e-05	200	124	6	b5a54b9baf79aea01f76a161f0a39bbe87eb4945
ToppCell	Tracheal-NucSeq-Stromal-Chondrocytic-Chondrocyte\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	CLEC18A CLEC18B SYNE1 CLEC18C LRP1B IVNS1ABP	2.07e-05	200	124	6	f5bd0b30e478dac09f68c46b0781f5f2e7e3c693
ToppCell	Parenchyma_COVID-19-Epithelial-TX-Basal_1\|Parenchyma_COVID-19 / Sample group, Lineage and Cell type	GPC1 FAT2 EGFR HES1 LGR6 AGRN	2.07e-05	200	124	6	592c7c3ded409a9957cbcdc62fcc213fa8eae598
ToppCell	Control-Control-Others-Platelet\|Control / Disease, condition lineage and cell class	PPBP TSPAN9 EGF MYEOV SEC14L5 SCGB1C1	2.07e-05	200	124	6	e0463c93714ab5fd00f294cca83bd61027fe0e95
ToppCell	LPS_IL1RA-Hematopoietic_Erythro-Megakary-Erythro-Mega\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	TENT5C PPBP STRADB EGF SEC14L5 KNL1	2.07e-05	200	124	6	f99e214eb680fd82a33f2b1524fbfca265d1cc42
ToppCell	Lung_Parenchyma-Severe-Epithelial-Epithelial-Basal_1-\|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	GPC1 FAT2 EGFR HES1 LGR6 AGRN	2.07e-05	200	124	6	8cfbde43c5e66269ad128aa5398b1517667d7d36
ToppCell	LPS_IL1RA-Hematopoietic_Erythro-Megakary\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	TENT5C PPBP STRADB EGF SEC14L5 KNL1	2.07e-05	200	124	6	d85074b362b11e5a523a5325d203a61aa2759a7a
ToppCell	Lung_Parenchyma-Severe-Epithelial-Epithelial-Basal_1\|Severe / Location, Disease Group, Cell group, Cell class (2021.03.09)	GPC1 FAT2 EGFR HES1 LGR6 AGRN	2.07e-05	200	124	6	61811380d9252f12f27b7ad4752380b52692677f
ToppCell	PBMC-Mild-Myeloid-Neutrophil-immature_Neutrophil-\|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	GPC1 PKD1L1 ORC1 BMPR1B DGKI	4.86e-05	142	124	5	e160f35b3c18e77c4107fe96db5f56227c91785e
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ANK3 IVNS1ABP MEX3A LRP2 SNTG1	6.51e-05	151	124	5	f4f7156b2c0cfc78fd1841e07c9915d97ced561f
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Intercalated_Cell_Type_B\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTSL3 ORC1 BMPR1B ABCA5 DGKI	6.71e-05	152	124	5	655d47efe0608d729801f1f01668e84c1bc0675f
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_IT-L5_IT_VISp_Col27a1\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	CDKN1A ONECUT2 CACNA1S CLEC18A ITGA8	7.14e-05	154	124	5	d22902d2922784583f7016453768ed05b14b965e
ToppCell	343B-Myeloid-Macrophage-SPP1+_Macrophage_2\|343B / Donor, Lineage, Cell class and subclass (all cells)	CDKN1A CPS1 PLAUR C9 METTL22	7.36e-05	155	124	5	84221a285277292f7225eb69508c887541abeed1
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWA3A CPS1 LRP1B LRP2 TDRD6	8.55e-05	160	124	5	c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCell	facs-Marrow-Granulocytes-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ONECUT2 ITGA8 TENT5C LRP1 AGRN	8.55e-05	160	124	5	56e6f4b82b5dc41c45f9d253c2db314a6f702b84
ToppCell	facs-Marrow-Granulocytes-18m-Hematologic-megakaryocyte-erythroid_progenitor_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ONECUT2 ITGA8 TENT5C LRP1 AGRN	8.55e-05	160	124	5	bb1b966fb9e801db15e67d03e49db4609d6f935a
ToppCell	facs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWA3A CPS1 LRP1B LRP2 TDRD6	8.55e-05	160	124	5	25c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell	Basal_cells-Donor_04\|World / lung cells shred on cell class, cell subclass, sample id	LRP1B BMPR1B FAT2 HES1 LGR6	8.55e-05	160	124	5	b223cc47e68a29df4758c5ccf8f6dbffe2a6fa1d
ToppCell	droplet-Marrow-BM-30m-Lymphocytic-NK_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RHOT2 ACVR1B PIAS3 DQX1 LRP1	9.61e-05	164	124	5	b77995958c938e10a526118f75d78cee72e0b207
ToppCell	10x_3'_v3-tissue-resident_(10x_3'_v3)-hematologic-erythrocytic-erythroid_lineage_cell\|tissue-resident_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	TYRP1 STRADB SCGB2A1 SCGB1C2 UNC5D	1.14e-04	170	124	5	288014dedda8babc51fe08e48a55e68d83e1b1d2
ToppCell	PND10-Epithelial-Epithelial_Alveolar-Epithelial_Alveolar-AT2-AT2_prolif\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ANK3 POLA1 LRP2 UNC5D SCGB1C1	1.14e-04	170	124	5	4ce81608111b9ee7cb974dad2c182f38db3dcd79
ToppCell	Control-Classical_Monocyte-cMono_4\|Classical_Monocyte / Disease condition and Cell class	CDKN1A ACVR1B LDLR HES1 PLAUR	1.14e-04	170	124	5	9e328e1f904c77dcce8aee4df775d7f0ac725775
ToppCell	droplet-Lung-immune-endo-depleted-3m-Lymphocytic-Proliferating_NK\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPC1 REXO5 POLA1 PRIM1 ATM	1.17e-04	171	124	5	1eebd7138c3b20ddc1104f21615f9df0e776bbe6
ToppCell	P15-Mesenchymal-developing_mesenchymal_cell-mesenchymal_proliferating_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	POLA1 PPP1R26 ORC1 PRIM1 KNL1	1.20e-04	172	124	5	7c238a7375341d4647ba7274d93fddfb6fae7ce4
ToppCell	facs-Heart-RA-3m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DTX1 CARD6 PLAUR BANK1 KNL1	1.23e-04	173	124	5	49030c2dd04b592655df1a667e2f90efb499e0a5
ToppCell	facs-Heart-RA-3m-Lymphocytic-B_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DTX1 CARD6 PLAUR BANK1 KNL1	1.23e-04	173	124	5	1cfbab6603f8baf8e238837bb72740c43a7dc0ec
ToppCell	droplet-Thymus-nan-3m-Lymphocytic-Double_negative_thymocyte,_DN3_(Cd8-,_Cd4-),_some_express_pre_TCR_alpha\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDKN1A SPRY1 CPT1A LDLR HES1	1.27e-04	174	124	5	0fccd90ef72ec2e5eb369fe6d6d126c60886485a
ToppCell	droplet-Thymus-nan-3m-Lymphocytic-DN3_thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CDKN1A SPRY1 CPT1A LDLR HES1	1.27e-04	174	124	5	b2fc2a756f8e373ad903bd416d9de703d945fa1c
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADAMTSL1 ITPR2 BMPR1B ABCA5 DGKI	1.27e-04	174	124	5	5f4436863a40f8bca46e2989bca66c02b6be88d4
ToppCell	PCW_13-14-Hematologic_ErythroMegGranulo-Hem_ErythroMeg\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	TENT5C PPBP STRADB EGF BANK1	1.30e-04	175	124	5	c33317d8d60ea88ec326daf91dfd3416a62f9938
ToppCell	facs-Heart-RV-18m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPC1 LRRC43 LRP1B MEX3A WFIKKN2	1.30e-04	175	124	5	d8e385320f554d974538b7cdc4f8e4767f1455f2
ToppCell	facs-Heart-RV-18m-Mesenchymal-smooth_muscle_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPC1 LRRC43 LRP1B MEX3A WFIKKN2	1.30e-04	175	124	5	cf15465855602ba135752c18755e3e058dbd42ec
ToppCell	facs-Trachea-24m-Endothelial-endothelial_cell_of_trachea-tracheal_endothelial_cell-tracheal_endothelial_cell_l54\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	ADAMTSL1 DTX1 TSPAN9 C9 PRRT4	1.34e-04	176	124	5	460cb302c5b3d609c65b924e1d4e8ea057a68485
ToppCell	Severe-CD4+_T_activated\|World / Disease group and Cell class	ANK3 TSPAN9 TDRD7 TLR3 LONRF2	1.41e-04	178	124	5	ef6111238703579a34bd6948bd9d4ca6b7e16063
ToppCell	PBMC-Convalescent-Hematopoietic-Platelet\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	PPBP TSPAN9 EGF SCGB1C2 MYEOV	1.41e-04	178	124	5	f5d83ad082e31d5601890d245b9fb4f9ef6a062b
ToppCell	PBMC-Convalescent-Hematopoietic-Platelet-Platelet\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	PPBP TSPAN9 EGF SCGB1C2 MYEOV	1.41e-04	178	124	5	a2a8fc14f492a4695e6991a357b6626145f1bf7f
ToppCell	PBMC-Convalescent-Hematopoietic-Platelet-Platelet\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PPBP TSPAN9 EGF SCGB1C2 MYEOV	1.45e-04	179	124	5	510927794bbd21814eba75286e0801eb1fd2e8a6
ToppCell	PBMC-Convalescent-Hematopoietic\|Convalescent / Location, Disease Group, Cell group, Cell class (2021.03.09)	PPBP TSPAN9 EGF SCGB1C2 MYEOV	1.45e-04	179	124	5	3b1616e974ea7792ff5c37da3b0281f28edfbb56
ToppCell	PBMC-Convalescent-Hematopoietic\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PPBP TSPAN9 EGF SCGB1C2 MYEOV	1.45e-04	179	124	5	35271a4396a533f6d960ce55d171a32d9d2fd1a4
ToppCell	PBMC-Convalescent-Hematopoietic-Platelet\|Convalescent / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PPBP TSPAN9 EGF SCGB1C2 MYEOV	1.45e-04	179	124	5	906a5ebbbac660b6fd498ced09d0ada40a3e64af
ToppCell	COVID-19-kidney-Stressed_EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	SELE SPRY1 ITGA8 IVNS1ABP HES1	1.45e-04	179	124	5	754f69bac7a1d5137f5141f6193285ccbfe361cb
ToppCell	3'-Adult-Appendix-Hematopoietic-Plasma_cells-IgA_plasma_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ADAMTSL1 RTTN PRSS53 MYEOV KNL1	1.45e-04	179	124	5	2285e3a9018a60d7f6e974fee46b6f61d39aa76f
Drug	monatepil	LRP1B LDLR LRP1 LRP2 SORL1	4.18e-07	29	121	5	CID000060810
Drug	Calpain inhibitor I	CDKN1A ONECUT2 PSMB10 LRP1B LDLR EGFR LRP1 LRP2 CTSB SORL1	2.57e-06	280	121	10	CID000004332
Drug	Plant Preparations	CDKN1A RPS2 PTPRU LDLR EGF EGFR LRP1 LRP2 ALB CTSB	7.27e-06	315	121	10	ctd:D028321
Drug	Guaifenesin [93-14-1]; Down 200; 20.2uM; HL60; HT_HG-U133A	MDFIC SYNE1 KDM5C CPS1 CPT1A ITPR2 PIAS3 ABCA5	1.06e-05	197	121	8	2569_DN
Drug	Hydroxamic Acids	CDKN1A EGF EGFR ALB	1.21e-05	27	121	4	ctd:D006877
Drug	Gallic Acid	CDKN1A LDLR EGF EGFR ALB ATM	1.32e-05	97	121	6	ctd:D005707
Drug	sodium linoleate	CPT1A LRP1B LDLR EGF EGFR LRP1 LRP2 ALB C9 SORL1	1.48e-05	342	121	10	CID000003931
Drug	D-tryptophan methyl ester	SYNE1 PSMB10 CTSB	2.34e-05	11	121	3	CID000077980
Drug	probucol	SELE LRP1B LDLR LRP1 LRP2 ALB SORL1	2.59e-05	162	121	7	CID000004912
Drug	5-ethylbarbituric acid	EGF EGFR	2.80e-05	2	121	2	CID000017292
Drug	5-phenylbarbituric acid	EGF EGFR	2.80e-05	2	121	2	CID000089646
Drug	Bio-Phe-Ala-CHN2	EGF CTSB	2.80e-05	2	121	2	CID005483648
Drug	Vinca-type compound	EGF EGFR	2.80e-05	2	121	2	CID000494342
Drug	epicholesterol	SELE CPT1A PPBP LRP1B LDLR EGF EGFR ABCA5 TLR3 LRP1 LRP2 ALB SORL1	3.46e-05	636	121	13	CID000000304
Drug	Dicumarol	CDKN1A RB1CC1 ALB ATM	3.50e-05	35	121	4	ctd:D001728
Drug	SB 203580	SELE CDKN1A TYRP1 EGF EGFR TLR3 LRP1 PLAUR ALB MUC5AC	4.34e-05	388	121	10	ctd:C093642
Drug	tyrphostin AG 1478	CDKN1A EGF EGFR HES1 ALB MUC5AC	4.86e-05	122	121	6	ctd:C101044
Disease	Colorectal Carcinoma	SYNE1 OBSCN PTPRU ADAMTSL3 ZNHIT6 EGFR ABCA5 LRP1 LRP2 LGR6 LONRF2 ZNF471 SORL1	5.42e-06	702	119	13	C0009402
Disease	autosomal dominant polycystic kidney disease (is_marker_for)	CDKN1A ITGA8 C9	2.25e-05	14	119	3	DOID:898 (is_marker_for)
Disease	cataract	PKD1L1 TENT5C CPT1A LRP1B FAF1 MYEOV	2.38e-05	141	119	6	MONDO_0005129
Disease	Prostatic Neoplasms	CDKN1A ONECUT2 LRP1B IVNS1ABP BMPR1B EGF EGFR LRP2 PLAUR ATM CTSB	4.13e-05	616	119	11	C0033578
Disease	Malignant neoplasm of prostate	CDKN1A ONECUT2 LRP1B IVNS1ABP BMPR1B EGF EGFR LRP2 PLAUR ATM CTSB	4.13e-05	616	119	11	C0376358
Disease	pancreatic cancer (is_marker_for)	ACVR1B EGF ALB MUC5AC MUC6	5.70e-05	101	119	5	DOID:1793 (is_marker_for)
Disease	pancreatic ductal carcinoma (is_marker_for)	CDKN1A EGF ALB MUC5AC	1.10e-04	61	119	4	DOID:3587 (is_marker_for)
Disease	creatinine measurement, glomerular filtration rate	CACNA1S CPS1 TSPAN9 LRP2 C9	1.15e-04	117	119	5	EFO_0004518, EFO_0005208
Disease	mucinous adenocarcinoma (is_marker_for)	MUC5AC MUC6	1.60e-04	5	119	2	DOID:3030 (is_marker_for)
Disease	low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio	CARMIL1 CPT1A LDLR FAF1 PLAUR BANK1	1.65e-04	200	119	6	EFO_0004611, EFO_0020945
Disease	Malignant Neoplasms	CDKN1A BIRC6 EGFR PLAUR ATM	1.75e-04	128	119	5	C0006826
Disease	hepatocellular carcinoma (is_marker_for)	GPC1 KDM5C CPS1 LRP1B EGFR TLR3 ALB	2.27e-04	301	119	7	DOID:684 (is_marker_for)
Disease	oral mucosa leukoplakia (is_marker_for)	CDKN1A ATM	2.39e-04	6	119	2	DOID:9655 (is_marker_for)
Disease	lung non-small cell carcinoma (is_implicated_in)	ACVR1B LRP1B EGF EGFR ATM	2.56e-04	139	119	5	DOID:3908 (is_implicated_in)
Disease	level of Sterol ester (27:1/20:4) in blood serum	CPT1A PPBP SCGB2A1	2.65e-04	31	119	3	OBA_2045198
Disease	Glioblastoma	EGF EGFR HES1 CTSB	2.99e-04	79	119	4	C0017636
Disease	Childhood Oligodendroglioma	DTX1 HES1	3.34e-04	7	119	2	C0280475
Disease	Adult Oligodendroglioma	DTX1 HES1	3.34e-04	7	119	2	C0279070
Disease	autosomal dominant polycystic kidney disease (biomarker_via_orthology)	CDKN1A LRP2	3.34e-04	7	119	2	DOID:898 (biomarker_via_orthology)
Disease	Oligodendroblastoma	DTX1 HES1	3.34e-04	7	119	2	C0344461
Disease	Mixed Oligodendroglioma-Astrocytoma	DTX1 HES1	3.34e-04	7	119	2	C0280793
Disease	Mixed Oligodendroglioma-Ependymoma	DTX1 HES1	3.34e-04	7	119	2	C0751395
Disease	Well Differentiated Oligodendroglioma	DTX1 HES1	3.34e-04	7	119	2	C0751396
Disease	cervical cancer	PIAS3 EGFR HES1	3.49e-04	34	119	3	C4048328
Disease	Giant Cell Glioblastoma	EGF EGFR HES1 CTSB	3.78e-04	84	119	4	C0334588
Disease	mitochondrial DNA measurement	MDFIC CARMIL1 GMIP RB1CC1 LDLR PLAUR BANK1	3.81e-04	328	119	7	EFO_0006312
Disease	Uterine Cervical Neoplasm	PIAS3 EGFR HES1	3.81e-04	35	119	3	C0007873
Disease	liver fibrosis measurement	CARMIL1 LDLR SCGB1C2 SCGB1C1	4.14e-04	86	119	4	EFO_0010576
Disease	Paroxysmal atrial fibrillation	SELE CDKN1A RPS2 HERC1 SORL1	4.36e-04	156	119	5	C0235480
Disease	familial atrial fibrillation	SELE CDKN1A RPS2 HERC1 SORL1	4.36e-04	156	119	5	C3468561
Disease	Persistent atrial fibrillation	SELE CDKN1A RPS2 HERC1 SORL1	4.36e-04	156	119	5	C2585653
Disease	bilirubin measurement	KRT78 CARMIL1 CPS1 BIRC6 EGF ALB LGR6 ARMC6	4.38e-04	442	119	8	EFO_0004570
Disease	oligodendroglioma	DTX1 HES1	4.44e-04	8	119	2	C0028945
Disease	PARTINGTON X-LINKED MENTAL RETARDATION SYNDROME	POLA1 KDM5C	4.44e-04	8	119	2	C0796250
Disease	Anaplastic Oligodendroglioma	DTX1 HES1	4.44e-04	8	119	2	C0334590
Disease	Cataract	INTS1 TDRD7 ATM	4.50e-04	37	119	3	C0086543
Disease	Kidney Diseases	CDKN1A EGF LRP2 ALB	4.52e-04	88	119	4	C0022658
Disease	platelet crit	CARMIL1 RTTN TENT5C CPS1 ITPR2 EGF EGFR DQX1 PRIM1 PLAUR MYEOV SORL1	4.77e-04	952	119	12	EFO_0007985
Disease	Atrial Fibrillation	SELE CDKN1A RPS2 HERC1 SORL1	4.89e-04	160	119	5	C0004238
Disease	lung non-small cell carcinoma (is_marker_for)	CDKN1A EGF EGFR ALB ATM	6.27e-04	169	119	5	DOID:3908 (is_marker_for)
Disease	renal cell carcinoma	FAF1 ITPR2 ATM	6.55e-04	42	119	3	EFO_0000681
Disease	Human papillomavirus infectious disease (is_marker_for)	EGFR TLR3	7.11e-04	10	119	2	DOID:11166 (is_marker_for)
Disease	interventricular septum thickness	CDKN1A ITPR2	7.11e-04	10	119	2	EFO_0009287
Disease	Lung Neoplasms	CDKN1A ANK3 PPBP TYRP1 EGFR HES1	7.38e-04	265	119	6	C0024121
Disease	schizophrenia (is_marker_for)	ANK3 EGF EGFR	7.51e-04	44	119	3	DOID:5419 (is_marker_for)
Disease	Malignant neoplasm of lung	CDKN1A ANK3 PPBP TYRP1 EGFR HES1	7.52e-04	266	119	6	C0242379
Disease	atrial fibrillation	CDKN1A RPS2 FAF1 ITPR2 HERC1 BANK1 SORL1	7.88e-04	371	119	7	EFO_0000275
Disease	HIV Infections	CDKN1A PSMB10 TLR3 ALB	8.17e-04	103	119	4	C0019693
Disease	HIV Coinfection	CDKN1A PSMB10 TLR3 ALB	8.17e-04	103	119	4	C4505456
Disease	tyrosine measurement	CLEC18A ADAMTSL1 CPS1 MYEOV	8.47e-04	104	119	4	EFO_0005058
Disease	Neoplasm Invasiveness	EGF EGFR PLAUR CTSB SORL1	9.19e-04	184	119	5	C0027626
Disease	platelet component distribution width	SYNE1 CARMIL1 RTTN TENT5C CPS1 TSPAN9 EGF EGFR HERC1 SEC14L5	9.86e-04	755	119	10	EFO_0007984
Disease	lung adenocarcinoma (is_implicated_in)	LRP1B EGF EGFR	1.03e-03	49	119	3	DOID:3910 (is_implicated_in)
Disease	autoimmune thyroiditis (is_implicated_in)	LRP2 BANK1	1.04e-03	12	119	2	DOID:7188 (is_implicated_in)
Disease	Papilloma	CDKN1A EGFR	1.04e-03	12	119	2	C0030354
Disease	Papillomatosis	CDKN1A EGFR	1.04e-03	12	119	2	C0205875
Disease	Papilloma, Squamous Cell	CDKN1A EGFR	1.04e-03	12	119	2	C0205874
Disease	familial hyperlipidemia (implicated_via_orthology)	LDLR ALB	1.04e-03	12	119	2	DOID:1168 (implicated_via_orthology)
Disease	Glioblastoma Multiforme	EGF EGFR HES1 CTSB	1.08e-03	111	119	4	C1621958
Disease	aspartate aminotransferase measurement	CDKN1A ONECUT2 CACNA1S RBBP5 CARMIL1 OBSCN BIRC6 TSPAN9 ADAMTS12 BANK1 ARMC6	1.10e-03	904	119	11	EFO_0004736
Disease	pneumonia, COVID-19	ADAMTSL1 LRP1B TYRP1 UNC5D	1.15e-03	113	119	4	EFO_0003106, MONDO_0100096
Disease	gallbladder cancer (is_implicated_in)	LRP1B EGF	1.22e-03	13	119	2	DOID:3121 (is_implicated_in)
Disease	Hereditary Diffuse Gastric Cancer	CDKN1A ITGA8 EGFR ALB ATM MUC6	1.24e-03	293	119	6	C1708349
Disease	Stomach Neoplasms	CDKN1A ITGA8 EGFR ALB ATM MUC6	1.33e-03	297	119	6	C0038356
Disease	Mammary Carcinoma, Human	SYNE1 RB1CC1 CPT1A EGF EGFR HES1 ATM LGR6	1.33e-03	525	119	8	C4704874
Disease	Mammary Neoplasms, Human	SYNE1 RB1CC1 CPT1A EGF EGFR HES1 ATM LGR6	1.33e-03	525	119	8	C1257931
Disease	Malignant neoplasm of breast	GPC1 RTP1 SYNE1 OBSCN RB1CC1 CPT1A EGF EGFR HES1 ATM LGR6 SORL1	1.35e-03	1074	119	12	C0006142
Disease	Mammary Neoplasms	SYNE1 RB1CC1 CPT1A EGF EGFR HES1 ATM LGR6	1.36e-03	527	119	8	C1458155
Disease	Malignant neoplasm of stomach	CDKN1A ITGA8 EGFR ALB ATM MUC6	1.40e-03	300	119	6	C0024623
Disease	gastric ulcer (implicated_via_orthology)	MUC5AC MUC6	1.42e-03	14	119	2	DOID:10808 (implicated_via_orthology)
Disease	membranous glomerulonephritis (biomarker_via_orthology)	PTPRU LRP2	1.42e-03	14	119	2	DOID:10976 (biomarker_via_orthology)
Disease	optic disc size measurement	ADAMTSL3 LRP1B TSPAN9 LRP2 MYEOV	1.48e-03	205	119	5	EFO_0004832
Disease	Breast Carcinoma	SYNE1 RB1CC1 CPT1A EGF EGFR HES1 ATM LGR6	1.55e-03	538	119	8	C0678222
Disease	asthma (is_marker_for)	BMPR1B EGFR TLR3 MUC5AC	1.72e-03	126	119	4	DOID:2841 (is_marker_for)
Disease	asthma (biomarker_via_orthology)	EGFR PRMT1 MUC5AC	1.76e-03	59	119	3	DOID:2841 (biomarker_via_orthology)
Disease	platelet measurement	CARMIL1 RTTN CPS1 EGF BANK1 SEC14L5	1.79e-03	315	119	6	EFO_0005036
Disease	Urticaria	SELE ALB	1.87e-03	16	119	2	C0042109
Disease	Dermatitis	EGF EGFR	1.87e-03	16	119	2	C0011603
Disease	acute kidney failure (biomarker_via_orthology)	EGF EGFR HES1	1.94e-03	61	119	3	DOID:3021 (biomarker_via_orthology)
Disease	pre-malignant neoplasm (biomarker_via_orthology)	CDKN1A ATM	2.11e-03	17	119	2	DOID:0060071 (biomarker_via_orthology)
Disease	otitis media (biomarker_via_orthology)	CTSB MUC5AC	2.11e-03	17	119	2	DOID:10754 (biomarker_via_orthology)
Disease	oral squamous cell carcinoma (is_marker_for)	CDKN1A EGFR ATM	2.13e-03	63	119	3	DOID:0050866 (is_marker_for)
Disease	cholangiocarcinoma (is_marker_for)	ALB MUC5AC MUC6	2.23e-03	64	119	3	DOID:4947 (is_marker_for)
Disease	pelvic organ prolapse	SPRY1 MDFIC ADAMTSL1 BAALC-AS2	2.28e-03	136	119	4	EFO_0004710
Disease	creatinine measurement	CACNA1S OBSCN CPS1 BIRC6 LDLR TSPAN9 LRP2 MYEOV C9 CTSB SORL1	2.33e-03	995	119	11	EFO_0004518
Disease	lymphocyte count	IPPK CACNA1S CLEC18C CPS1 FAF1 ITPR2 EGF EGFR SCGB1C2 PLAUR MYEOV ATM KNL1 SCGB1C1	2.34e-03	1464	119	14	EFO_0004587
Disease	Bladder Neoplasm	CDKN1A VWA3A EGFR ATM	2.53e-03	140	119	4	C0005695
Disease	Malignant neoplasm of urinary bladder	CDKN1A VWA3A EGFR ATM	2.59e-03	141	119	4	C0005684
Disease	laryngeal squamous cell carcinoma (is_marker_for)	CDKN1A EGFR	2.64e-03	19	119	2	DOID:2876 (is_marker_for)
Disease	polycystic kidney disease (biomarker_via_orthology)	C9 CTSB	2.64e-03	19	119	2	DOID:0080322 (biomarker_via_orthology)
Disease	Benign Neoplasm	BIRC6 PLAUR ATM	2.65e-03	68	119	3	C0086692
Disease	Neoplasms	BIRC6 PLAUR ATM	2.65e-03	68	119	3	C0027651
Disease	Abdominal Aortic Aneurysm	CDKN1A LDLR LRP1	2.65e-03	68	119	3	EFO_0004214
Disease	citrulline measurement	CPS1 CTSB	2.92e-03	20	119	2	EFO_0009777
Disease	Adenocarcinoma of prostate	EGFR ATM	2.92e-03	20	119	2	C0007112
Disease	Conventional (Clear Cell) Renal Cell Carcinoma	KDM5C LRP1B ATM CTSB	3.09e-03	148	119	4	C0279702
Disease	Schizophrenia	ANK3 ITGA8 RB1CC1 ADAMTSL3 ADAMTS12 TLR3 LRP1 LRP2 ATM KPNA1	3.10e-03	883	119	10	C0036341
Disease	BREAST CANCER	RB1CC1 ATM	3.22e-03	21	119	2	114480
Disease	cerebellar cortex volume measurement	CPS1 SNTG1	3.22e-03	21	119	2	EFO_0010291
Disease	blood pressure	SYNE1 BANK1	3.53e-03	22	119	2	EFO_0004325

Protein segments in the cluster

Peptide	Gene	Start	Entry
IYMDSRAGCSKSCEA	ABCA5	151	Q8WWZ7
KECLFRMADSGESLC	BANK1	286	Q8NDB2
SRDCDALMAGCIQEA	CDKN1A	31	P38936
VATLRETYGEMADCC	ALB	101	P02768
SGDDRAMCFTCSVCL	BIRC6	321	Q9NR09
VEVSAEDLLTCCGSM	CTSB	131	P07858
RCSCILNLEESMDSD	BAALC-AS2	56	P0C853
CETDGACMVSIFNLD	ACVR1B	46	P36896
MSERCCSRYSSGASI	ARMC6	1	Q6NXE6
CEADASAPATCAEMR	AGRN	891	O00468
RDSFCGCSSSEILRM	CCNI	116	Q14094
RSCTTESCDFVRAMV	CPT1A	606	P50416
GDLDTSLCDICMCSI	ANKIB1	326	Q9P2G1
SLCDICMCSISVFED	ANKIB1	331	Q9P2G1
ICSTDGYCFTMIEED	BMPR1B	46	O00238
RRVECSTQMDSDCAA	ADAMTS12	1336	P58397
KGQLCELSCSTDYRM	PRMT1	356	Q99873
CDKDLDTLSGYAMCL	IPPK	101	Q9H8X2
YEDGIERTCDTLLMC	ITPR2	2471	Q14571
ECMAADRRVCTYSAG	RB1CC1	51	Q8TDY2
CATLSEYSRQCSMVG	MUC6	271	Q6W4X9
MVRNSTRCYCEDGFE	LRP1B	131	Q9NZR2
ESDSICGAITCAADM	LRP1B	2751	Q9NZR2
GIMDACCESSDCLEI	MDFIC	221	Q9P1T7
LMSSAEECCRNLAFS	INTS1	2091	Q8N201
CGDYLLSRMDVTSCI	IVNS1ABP	121	Q9Y6Y0
DSCDSDAIERMYCAP	RPS6KC1	956	Q96S38
CQEDGIMLSADCSEL	LGR6	41	Q9HBX8
CSEKMALSTASDDRC	GPC1	401	P35052
FMVSGTECEECFLTC	GMIP	511	Q9P107
ETTRSCMCTAGYSLR	LRP1	1866	Q07954
EEVCRMASDYSRTCA	HERC1	341	Q15751
GTRCYTESLDMCISG	ADAMTSL1	141	Q8N6G6
MRALDFADESGSVSC	HMGN2P46	6	Q86SG4
SCSADEVMRFFSDCK	HNRNPH2	21	P55795
YTGDRCEMEARGCSE	FAT2	4016	Q9NYQ8
LCCEYLAEATESSMG	PEAK3	451	Q6ZS72
TAYRCLTKDLEGCAM	ONECUT2	6	O95948
LLEGEECRMSGECTS	KRT78	416	Q8N1N4
ALCMTLAESSCPDYE	MYEOV	216	Q96EZ4
CSISCDRGYLPSSME	SELE	206	P16581
TTCTFDCEEGFELMG	SELE	266	P16581
SCTDNLEGSAMLLCD	KNL1	1336	Q8NG31
FRCSCDTGYMLESDG	LRP2	1411	P98164
SLDVTDFECALCMRL	LONRF2	441	Q1L5Z9
LSCSLDEARMSKDGC	MUC5AC	5501	P98088
SRAFSYTEVEECGCM	MUC5AC	5601	P98088
CTICMERLVTASGYE	DTX1	411	Q86Y01
SCEFDCVDEMLTLAA	DQX1	481	Q8TE96
TDMEPSLYRCSNIDC	POLA1	1301	P09884
DSMTSAACFSLRVCA	ITGA8	511	P53708
EADGTLDCISMALTC	RBBP5	16	Q15291
RSGTFCACATVLEMI	PTPRU	1386	Q92729
MVDAAEYSCVCGEER	OBSCN	3336	Q5VST9
DMTDYDDVRRCCSSA	PRIM1	111	P49642
YREMCVKTEGCSTEI	ORC1	31	Q13415
AAELLMSCFRVCASD	PCID2	141	Q5JVF3
MSCFRVCASDTRAGI	PCID2	146	Q5JVF3
SCVRACGADSYEMEE	EGFR	306	P00533
SCIMDVSLRSFSLCC	ATM	1481	Q13315
TYMCRAGAIRTDDNC	ARMC8	261	Q8IUR7
RCEMASTGEVACFGE	CPS1	1326	P31327
EVMFSSCLRCVSVED	CARD6	631	Q9BX69
SCLRCVSVEDMAALA	CARD6	636	Q9BX69
SMYARCISEGEDATC	EGF	841	P01133
RCTDLSKMTEEECRG	CACNA1S	956	Q13698
VRGDCDLETCRMYID	DGKI	776	O75912
AMSRCETCGTEEAKY	ZNHIT6	216	Q9NWK9
NDPVESSLRCFCMTD	ANK3	1321	Q12955
MSVCSSDLSYGSRVC	KRTAP10-6	6	P60371
MSVCSSDLSYGSRVC	KRTAP10-7	6	P60409
MSVCSSDLSYGSRVC	KRTAP10-12	1	P60413
DQRDGCECEMGTYLS	CXorf38	221	Q8TB03
DLSNTECSLDMVCGA	CARMIL1	371	Q5VZK9
DDSMCLAESGLSYPC	FAF1	246	Q9UNN5
CEVLASEDFRGSMSS	SEC14L5	651	O43304
AMCEDCSEIPNLSYS	PKD1L1	916	Q8TDX9
ESLDSDLYAELRCMC	PPBP	51	P02775
MSACRSFAVAICILE	C9	1	P02748
LELYGNEISSMECLC	LRRC43	176	Q8N309
ECMNEVTRFLSTCEG	HES1	116	Q14469
LCYECGTARLDESSM	RTP1	131	P59025
CYECGTARLDESSML	RTP2	96	Q5QGT7
TAAIDMFCTCAGLSA	RTTN	1771	Q86VV8
TLTCMSREFQCEDGE	SORL1	1511	Q92673
MSGFLEGLRCSECID	TMEM50A	1	O95807
CTEDMRKSSCVESFD	TDRD6	1936	O60522
LACLVPMSEEDYSCA	SYNE1	8761	Q8NF91
SLDATCDVACLMFDG	RHOT2	481	Q8IXI1
MDFRTACEETKTGIC	SNTG1	1	Q9NSN8
IAGDSTMCRDYVLDC	KPNA1	196	P52294
ALTLFCICRMATGED	SCGB1C2	11	P0DMR2
SSCRADTSAELMCAE	PPP1R26	471	Q5T8A7
YCCGAGVAADAEMTT	PSMB10	81	P40306
RSGEITCYAMACTET	TDRD7	66	Q8NHU6
YCTDVGADLLSMCQR	METTL22	231	Q9BUU2
MAEESSCTRDCMSFS	TENT5C	1	Q5VWP2
TCDLRIDGDCFMVSS	CLEC18A	301	A5D8T8
TCDLRIDGDCFMVSS	CLEC18B	301	Q6UXF7
TCDLRIDGDCFMVSS	CLEC18C	301	Q8NCF0
DGLFMEILSSCSDCD	PIAS3	381	Q9Y6X2
EMSDEDSCVACGSLR	PRSS53	286	Q2L4Q9
TLQVRMSCECEADGY	ULBP3	121	Q9BZM4
NVCDICTDDLMGSRS	TYRP1	256	P17643
SECTDVLMGRSSLNC	ZNF441	106	Q8N8Z8
DMRFNPFDCTCESIA	TLR3	641	O15455
RSRYLECISCGSSDM	PLAUR	111	Q03405
LTRGLCSDLESMCET	ZNF383	71	Q8NA42
GRDCMVCFESEVTAA	MEX3A	466	A1L020
CYADSGCKLLEDMVE	SCGB2A1	16	O75556
LDCEMCLTSKGRELT	REXO5	231	Q96IC2
EEQLTSCGASDCLMA	UNC93A	171	Q86WB7
FCGLSRDSSSMLLCS	PRRT4	806	C9JH25
RQCLCSAESMVEYGT	SPRY1	206	O43609
ALTLFCICRMATGED	SCGB1C1	11	Q8TD33
EVMSVEDESTSCYCL	UNC5D	646	Q6UXZ4
TRGLCSDLESMCETK	ZNF829	101	Q3KNS6
LICLDCAMESSRNSS	USP41	176	Q3LFD5
ACMEGITSYGLECST	ZNF471	106	Q9BX82
MSLLDCFCTSRTQVE	STRADB	1	Q9C0K7
MEYCRTGSLCSLEVL	TRAPPC10	1071	P48553
MAGIDDCYTSARGCT	RPS2	216	P15880
GSCEITTREYCEFMH	RHBDF2	606	Q6PJF5
ECMECGKAFGRTSDL	ZNF571	196	Q7Z3V5
IQAEMRCCGVTDYTD	TSPAN9	141	O75954
TLSAYMAEACGGCDL	VWA3A	626	A6NCI4
RCYMDAEACSKGITL	WFIKKN2	156	Q8TEU8
CSECGESFSRSSRLM	ZNF263	661	O14978
LDGTRCNTDSLDMCI	ADAMTSL3	181	P82987
FIESYVCRMCSRGDE	KDM5C	321	P41229
GSRQCDREYDCKDMS	LDLR	251	P01130