Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	response to tetrachloromethane	IGF2R CPT1A	4.43e-05	5	44	2	GO:1904772
Domain	EamA_dom	SLC35E4 SLC35F4	4.63e-04	14	43	2	IPR000620
Domain	EamA	SLC35E4 SLC35F4	4.63e-04	14	43	2	PF00892
Domain	Leu-rich_rpt	ZYG11B FBXL16 CIITA LRRC32	3.43e-03	271	43	4	IPR001611
Domain	-	ZYG11B FBXL16 CIITA LRRC32	6.24e-03	321	43	4	3.80.10.10
Domain	L_dom-like	ZYG11B FBXL16 CIITA LRRC32	6.72e-03	328	43	4	IPR032675
Domain	LRR_6	FBXL16 CIITA	7.12e-03	55	43	2	PF13516
Pubmed	Association of KIR2DL5B gene with celiac disease supports the susceptibility locus on 19q13.4.	KIR2DL5A KIR2DL5B	1.71e-06	2	46	2	17215859
Pubmed	Some human KIR haplotypes contain two KIR2DL5 genes: KIR2DL5A and KIR2DL5B.	KIR2DL5A KIR2DL5B	1.71e-06	2	46	2	12185535
Pubmed	Gene structure and promoter variation of expressed and nonexpressed variants of the KIR2DL5 gene.	KIR2DL5A KIR2DL5B	1.71e-06	2	46	2	11086080
Pubmed	Impact of individual acute phase serum amyloid A isoforms on HDL metabolism in mice.	SAA2 SCARB1	5.13e-06	3	46	2	27018443
Pubmed	Serum amyloid A promotes cholesterol efflux mediated by scavenger receptor B-I.	SAA2 SCARB1	5.13e-06	3	46	2	16120612
Pubmed	Promoter variants of KIR2DL5 add to diversity and may impact gene expression.	KIR2DL5A KIR2DL5B	5.13e-06	3	46	2	18461314
Pubmed	Killer-cell immunoglobulin-like receptors (KIR) in severe A (H1N1) 2009 influenza infections.	KIR2DL5A KIR2DL5B	1.03e-05	4	46	2	22652695
Pubmed	KIR2DL5, a novel killer-cell receptor with a D0-D2 configuration of Ig-like domains.	KIR2DL5A KIR2DL5B	1.03e-05	4	46	2	10820258
Pubmed	Investigation of killer cell immunoglobulin-like receptor (KIR) gene diversity: KIR2DL2, KIR2DL5 and KIR2DS5.	KIR2DL5A KIR2DL5B	1.03e-05	4	46	2	18498296
Pubmed	E3 ubiquitin ligase RNF123 targets lamin B1 and lamin-binding proteins.	DNAH2 CFAP47 LAMB3 LTA4H USP22 RECQL4 CABLES1	4.82e-05	736	46	7	29676528
Pubmed	A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets.	LAMB3 LTA4H IGF2R ATP5PO CPT1A SCARB1	5.10e-05	503	46	6	36217030
Pubmed	A missense mutation in the previously undescribed gene Tmhs underlies deafness in hurry-scurry (hscy) mice.	SLC26A8 LHFPL3	1.12e-04	12	46	2	15905332
Pubmed	Different KIRs confer susceptibility and protection to adults with latent autoimmune diabetes in Latvian and Asian Indian populations.	KIR2DL5A KIR2DL5B	1.32e-04	13	46	2	19120281
Pubmed	Glycine prevents metabolic steatohepatitis in diabetic KK-Ay mice through modulation of hepatic innate immunity.	CPT1A CIITA	1.54e-04	14	46	2	27659424
Pubmed	[Polymorphism of killer cell immunoglobulin-like receptors gene family in Zhejiang Han population].	KIR2DL5A KIR2DL5B	2.03e-04	16	46	2	16403292
Pubmed	[Analysis of natural killer cell immunoglobulin-like receptor genes in Chinese].	KIR2DL5A KIR2DL5B	2.30e-04	17	46	2	19218127
Pubmed	Association of KIR2DS1 and KIR2DS3 with fatal outcome in Ebola virus infection.	KIR2DL5A KIR2DL5B	2.30e-04	17	46	2	20878400
Pubmed	Killer cell immunoglobulin-like receptor gene diversity in the Tibetan ethnic minority group of China.	KIR2DL5A KIR2DL5B	2.30e-04	17	46	2	20650299
Pubmed	Killer cell immunoglobulin-like receptor gene polymorphisms in patients with leukemia: possible association with susceptibility to the disease.	KIR2DL5A KIR2DL5B	2.30e-04	17	46	2	19450876
Pubmed	Distribution of killer-cell immunoglobulin-like receptor genes in Eastern mainland Chinese Han and Taiwanese Han populations.	KIR2DL5A KIR2DL5B	2.30e-04	17	46	2	19761533
Pubmed	Signatures of natural selection and coevolution between killer cell immunoglobulin-like receptors (KIR) and HLA class I genes.	KIR2DL5A KIR2DL5B	2.58e-04	18	46	2	20200544
Pubmed	Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.	TTLL11 LHFPL3 RECQL4	2.67e-04	94	46	3	25201988
Pubmed	HLA and KIR frequencies in Sicilian Centenarians.	KIR2DL5A KIR2DL5B	3.20e-04	20	46	2	20426625
Pubmed	Compound KIR-HLA genotype analyses in the Iranian population by a novel PCR-SSP assay.	KIR2DL5A KIR2DL5B	3.20e-04	20	46	2	20193031
Pubmed	In silico QTL mapping of basal liver iron levels in inbred mouse strains.	IGF2R LONP2	3.54e-04	21	46	2	21062905
Pubmed	Cholesterol 7α-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders.	CPT1A SCARB1	3.89e-04	22	46	2	27146480
Pubmed	Distribution of KIR genes in the population of unrelated individuals homozygous for ancestral haplotype AH8.1 (HLA-A1B8DR3).	KIR2DL5A KIR2DL5B	3.89e-04	22	46	2	20492596
Pubmed	Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.	ERGIC1 IGF2R ATP5PO CPT1A MTCH1	5.03e-04	499	46	5	22810586
Pubmed	A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.	ERGIC1 ZYG11B MTCH1 SCARB1	6.49e-04	298	46	4	32353859
Pubmed	High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface.	USP22 SCARB1 CABLES1 SHKBP1	7.26e-04	307	46	4	37499664
Pubmed	Analysis of the Tropism of SARS-CoV-2 Based on the Host Interactome of the Spike Protein.	LAMB3 CPT1A	7.77e-04	31	46	2	37939376
Pubmed	ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.	ERGIC1 USP34 LAMB3 IGF2R ATP5PO CPT1A SCARB1	9.49e-04	1201	46	7	35696571
Pubmed	A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex.	USP22 RECQL4	9.90e-04	35	46	2	23382074
Pubmed	Role of human leukocyte antigen, killer-cell immunoglobulin-like receptors, and cytokine gene polymorphisms in leptospirosis.	KIR2DL5A KIR2DL5B	9.90e-04	35	46	2	19683555
Pubmed	Association of genetic variants with chronic kidney disease in individuals with different lipid profiles.	SLC26A8 IGF2R CIITA	1.08e-03	152	46	3	19578796
GeneFamily	Solute carriers	SLC8A2 SLC26A8 SLC35E4 SLC16A2 MTCH1 SLC35F4	4.85e-05	395	31	6	752
GeneFamily	CD molecules\|Killer cell immunoglobulin like receptors	KIR2DL5A KIR2DL5B	4.28e-04	18	31	2	620
GeneFamily	Olfactory receptors, family 8	OR8J3 OR8J1	3.18e-03	49	31	2	155
GeneFamily	Ubiquitin specific peptidases	USP34 USP22	4.14e-03	56	31	2	366
Disease	multiple myeloma (is_marker_for)	IGF2R NOX1	1.15e-03	36	41	2	DOID:9538 (is_marker_for)
Disease	Hypercholesterolemia	NOX1 SCARB1	1.35e-03	39	41	2	C0020443
Disease	occupational attainment	TTLL11 LHFPL3	1.57e-03	42	41	2	EFO_0020977
Disease	Kidney Failure, Chronic	CPT1A SCARB1	2.04e-03	48	41	2	C0022661
Disease	linoleic acid measurement	IGF2R MTCH1 SCARB1	2.20e-03	186	41	3	EFO_0006807
Disease	triglycerides:total lipids ratio, high density lipoprotein cholesterol measurement	IGF2R CPT1A SCARB1	2.94e-03	206	41	3	EFO_0004612, EFO_0020947
Disease	periodontitis	ERGIC1 IGF2R TTLL11	3.67e-03	223	41	3	EFO_0000649
Disease	Non-alcoholic Fatty Liver Disease	CPT1A SCARB1	4.29e-03	70	41	2	C0400966
Disease	Nonalcoholic Steatohepatitis	CPT1A SCARB1	4.29e-03	70	41	2	C3241937
Disease	very low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio	IGF2R CPT1A SCARB1	4.46e-03	239	41	3	EFO_0008317, EFO_0020945
Disease	cholesteryl esters:total lipids ratio, high density lipoprotein cholesterol measurement	IGF2R CPT1A SCARB1	4.67e-03	243	41	3	EFO_0004612, EFO_0020944
Disease	monounsaturated fatty acids; 16:1, 18:1 measurement	IGF2R CPT1A	5.29e-03	78	41	2	EFO_0022187

Protein segments in the cluster

Peptide	Gene	Start	Entry
LVGLSCVTRFRAALS	CIITA	876	P33076
LFREGRTETVRSCTT	CPT1A	596	P50416
VSGLSRQVRCFSTSV	ATP5PO	6	P48047
VSIFTDRLGCRITAT	SLC16A2	161	P36021
TLLCRSRLGFTIFSL	KIR2DL5A	46	Q8N109
CSVDFTRRTLTGTAA	LTA4H	26	P09960
LSFLRGTCSFCSRTL	NOX1	76	Q9Y5S8
VTIVTCLASLFSGRL	LONP2	746	Q86WA8
KRIVFFSCRSISGST	MAF1	196	Q9H063
RFRIIITTCSSSGLF	MOV10L1	856	Q9BXT6
STLLSFSTAIGRTCI	MFSD9	381	Q8NBP5
VRYGIRLTTTAACSL	GABRQ	171	Q9UN88
TLLCRSRLGFTIFSL	KIR2DL5B	46	Q8NHK3
SVTIRSSRCRGIQAF	NUDT9	21	Q9BW91
RFITTICAIIGGTFT	ERGIC1	251	Q969X5
FTRVTEFILTGVSSC	OR8J3	6	Q8NGG0
GFLRRDTFTILFCTS	NPIPB15	66	A6NHN6
CVAFSGITSLRSLSL	LRRC32	436	Q14392
FTRVTEFILTGVSSC	OR8J1	6	Q8NGP2
ISGRRSFCSIFSVLP	CABLES1	341	Q8TDN4
GRTRFLRASSTCGLT	LAMB3	36	Q13751
FSASTGDRVTITCRA	IGKV1-8	31	A0A0C4DH67
FTSLTYDLIRSGCVR	DMBT1	2311	Q9UGM3
AFCVTSFIITNLGSR	DNAH2	3801	Q9P225
KGTITFSTTRRCTTR	CFAP47	2481	Q6ZTR5
RCVRITDTGLSYLST	FBXL16	381	Q8N461
RFSTRITFECAQISG	IGF2R	1181	P11717
RGSSLLFRRVSSGSC	MTCH1	371	Q9NZJ7
GLVFCSLVLSVSSRS	SAA2	6	P0DJI9
CFLGLTATATRRTAS	RECQL4	636	O94761
FRSCVFTGAIARTII	SLC26A8	406	Q96RN1
FVRLSSTGQRVCSVR	SHKBP1	521	Q8TBC3
LRSTLASFACRVATT	SCARB1	521	Q8WTV0
VTNFLGTSRSSVTRC	SLC35F4	66	A4IF30
TGFTLSLVSSLCRLV	SPICE1	366	Q8N0Z3
SLLRTLSFVGCGVSF	ADGRD2	656	Q7Z7M1
RTFSSILCRLSSKGV	TTLL11	456	Q8NHH1
TGFRTFIRSCKLSSS	TTLL11	661	Q8NHH1
RCFSRLSGLRALSIT	ZYG11B	156	Q9C0D3
VSGTTTLTDCLRRFT	USP22	356	Q9UPT9
GFTIFLSCLTVRSFQ	TAS1R1	641	Q7RTX1
LTFTEGCFVRSLSTV	SPATA12	166	Q7Z6I5
TRCRVLLLSLTFGTS	SLC35E4	106	Q6ICL7
VRLQFLTCVFSTLGS	USP34	986	Q70CQ2
TSFCRSDFVILGRVS	WFIKKN2	456	Q8TEU8
RELTCRGSFTDFSTL	LHFPL3	86	Q86UP9
RTGTLAFSVTLFTVF	SLC8A2	851	Q9UPR5