Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	acyltransferase activity	RGPD2 ITCH TRIM73 RNF19B ANAPC11 RFPL1 GTF3C4 FBXL5 CASD1 GLUL HERC1 MARCHF11 LNX1 TRIM74	2.49e-05	775	98	14	GO:0016746
GeneOntologyMolecularFunction	ubiquitin-like protein transferase activity	RGPD2 ITCH TRIM73 RNF19B ANAPC11 RFPL1 FBXL5 HERC1 MARCHF11 LNX1 TRIM74	4.24e-05	512	98	11	GO:0019787
GeneOntologyMolecularFunction	aminoacyltransferase activity	RGPD2 ITCH TRIM73 RNF19B ANAPC11 RFPL1 FBXL5 HERC1 MARCHF11 LNX1 TRIM74	5.99e-05	532	98	11	GO:0016755
GeneOntologyMolecularFunction	ubiquitin-protein transferase activity	ITCH TRIM73 RNF19B ANAPC11 RFPL1 FBXL5 HERC1 MARCHF11 LNX1 TRIM74	1.10e-04	473	98	10	GO:0004842
GeneOntologyMolecularFunction	transition metal ion binding	TRIM73 RNF19B AOX1 WRN MMP27 ANAPC11 FBXL5 PARP1 LIMS1 MID1 GLUL NR3C2 DMD MARCHF11 UTRN TRIM74	2.10e-04	1189	98	16	GO:0046914
GeneOntologyMolecularFunction	DNA translocase activity	FBH1 RAD54B	2.36e-04	5	98	2	GO:0015616
Domain	Dystrophin	DMD UTRN	2.73e-05	2	98	2	IPR016344
Domain	ATPase_dyneun-rel_AAA	DNAH3 MDN1 DNAH9	4.89e-05	14	98	3	IPR011704
Domain	AAA_5	DNAH3 MDN1 DNAH9	4.89e-05	14	98	3	PF07728
Domain	ConA-like_dom	RFPL1 MALRD1 NRXN1 MID1 EGFLAM HERC1 ALK	1.55e-04	219	98	7	IPR013320
Domain	EF-hand_dom_typ1	DMD UTRN	4.03e-04	6	98	2	IPR015153
Domain	EF-hand_dom_typ2	DMD UTRN	4.03e-04	6	98	2	IPR015154
Domain	EF-hand_2	DMD UTRN	4.03e-04	6	98	2	PF09068
Domain	EF-hand_3	DMD UTRN	4.03e-04	6	98	2	PF09069
Domain	FN3	EPHB4 IL12RB2 DCC IL21R MID1 EGFLAM	4.31e-04	185	98	6	SM00060
Domain	FN3	EPHB4 IL12RB2 DCC IL21R MID1 EGFLAM	6.33e-04	199	98	6	PS50853
Domain	zf-RING_UBOX	TRIM73 MID1 TRIM74	7.45e-04	34	98	3	PF13445
Domain	Znf-RING_LisH	TRIM73 MID1 TRIM74	7.45e-04	34	98	3	IPR027370
Domain	FN3_dom	EPHB4 IL12RB2 DCC IL21R MID1 EGFLAM	8.18e-04	209	98	6	IPR003961
Domain	ZF_RING_2	TRIM73 RNF19B ANAPC11 RFPL1 MID1 LNX1 TRIM74	9.84e-04	298	98	7	PS50089
Domain	RING	TRIM73 RNF19B ANAPC11 RFPL1 MID1 LNX1 TRIM74	1.13e-03	305	98	7	SM00184
Domain	zf-C3HC4	TRIM73 RFPL1 MID1 MARCHF11 LNX1 TRIM74	1.14e-03	223	98	6	PF00097
Domain	fn3	EPHB4 IL12RB2 DCC MID1 EGFLAM	1.64e-03	162	98	5	PF00041
Domain	Znf_RING	TRIM73 RNF19B ANAPC11 RFPL1 MID1 LNX1 TRIM74	1.65e-03	326	98	7	IPR001841
Domain	WW	ITCH DMD UTRN	1.92e-03	47	98	3	PF00397
Domain	WW	ITCH DMD UTRN	2.04e-03	48	98	3	SM00456
Domain	Dynein_heavy_chain_D4_dom	DNAH3 DNAH9	2.38e-03	14	98	2	IPR024317
Domain	Dynein_HC_stalk	DNAH3 DNAH9	2.38e-03	14	98	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH3 DNAH9	2.38e-03	14	98	2	IPR013602
Domain	DHC_N2	DNAH3 DNAH9	2.38e-03	14	98	2	PF08393
Domain	MT	DNAH3 DNAH9	2.38e-03	14	98	2	PF12777
Domain	AAA_8	DNAH3 DNAH9	2.38e-03	14	98	2	PF12780
Domain	WW_DOMAIN_1	ITCH DMD UTRN	2.43e-03	51	98	3	PS01159
Domain	WW_DOMAIN_2	ITCH DMD UTRN	2.43e-03	51	98	3	PS50020
Domain	-	TRIM73 RNF19B ANAPC11 RFPL1 MID1 MARCHF11 LNX1 TRIM74	2.50e-03	449	98	8	3.30.40.10
Domain	WW_dom	ITCH DMD UTRN	2.57e-03	52	98	3	IPR001202
Domain	DHC_fam	DNAH3 DNAH9	2.74e-03	15	98	2	IPR026983
Domain	Dynein_heavy	DNAH3 DNAH9	2.74e-03	15	98	2	PF03028
Domain	Dynein_heavy_dom	DNAH3 DNAH9	2.74e-03	15	98	2	IPR004273
Domain	Znf_RING/FYVE/PHD	TRIM73 RNF19B ANAPC11 RFPL1 MID1 MARCHF11 LNX1 TRIM74	2.86e-03	459	98	8	IPR013083
Domain	BACK	BTBD9 KLHL32 KLHL36	3.86e-03	60	98	3	SM00875
Domain	MAM	MALRD1 ALK	3.95e-03	18	98	2	PF00629
Domain	MAM_dom	MALRD1 ALK	3.95e-03	18	98	2	IPR000998
Domain	ZF_ZZ_2	DMD UTRN	3.95e-03	18	98	2	PS50135
Domain	ZF_ZZ_1	DMD UTRN	3.95e-03	18	98	2	PS01357
Domain	ZZ	DMD UTRN	3.95e-03	18	98	2	PF00569
Domain	MAM_2	MALRD1 ALK	3.95e-03	18	98	2	PS50060
Domain	BACK	BTBD9 KLHL32 KLHL36	4.04e-03	61	98	3	IPR011705
Domain	BACK	BTBD9 KLHL32 KLHL36	4.04e-03	61	98	3	PF07707
Domain	ZF_RING_1	TRIM73 RNF19B RFPL1 MID1 LNX1 TRIM74	4.32e-03	291	98	6	PS00518
Domain	Leu-rich_rpt_Cys-con_subtyp	FBXL5 NLRC5	4.40e-03	19	98	2	IPR006553
Domain	LRR_CC	FBXL5 NLRC5	4.40e-03	19	98	2	SM00367
Domain	Znf_ZZ	DMD UTRN	4.40e-03	19	98	2	IPR000433
Domain	ZnF_ZZ	DMD UTRN	4.40e-03	19	98	2	SM00291
Domain	WD40_repeat_dom	WDR70 ARHGEF17 GTF3C4 WDR43 NUP37 HERC1	4.77e-03	297	98	6	IPR017986
Domain	CH	DMD UTRN CNN2	4.84e-03	65	98	3	SM00033
Domain	BTB	ZBTB26 BTBD9 KLHL32 KLHL36	5.02e-03	131	98	4	PF00651
Domain	C2	ITCH ABR RASA1 CPNE4	5.02e-03	131	98	4	PF00168
Pathway	REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION	ITCH TRIM73 RNF19B ANAPC11 PSMB11 FBXL5 HERC1 LNX1 TRIM74	2.84e-05	299	75	9	MM15711
Pathway	REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION	ITCH TRIM73 RNF19B ANAPC11 PSMB11 FBXL5 HERC1 LNX1 TRIM74	8.22e-05	343	75	9	MM15712
Pubmed	The carboxyterminus of the ATP-binding cassette transporter A1 interacts with a beta2-syntrophin/utrophin complex.	AOX1 PRPF8 UTRN	8.25e-07	7	101	3	12054535
Pubmed	Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition.	TRIM73 RNF19B KLHL32 FBH1 KLHL36 NR3C2 LNX1 ALK TRIM74	1.46e-06	372	101	9	22939624
Pubmed	USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma.	PRPF8 ARHGEF17 OGDH PARP1 MDN1 DMD HERC1	5.74e-06	234	101	7	36243803
Pubmed	Decreased myocardial nNOS, increased iNOS and abnormal ECGs in mouse models of Duchenne muscular dystrophy.	DMD UTRN	8.35e-06	2	101	2	10525423
Pubmed	In Vivo Genome Editing Restores Dystrophin Expression and Cardiac Function in Dystrophic Mice.	DMD UTRN	8.35e-06	2	101	2	28790199
Pubmed	Metabolic dysfunction and altered mitochondrial dynamics in the utrophin-dystrophin deficient mouse model of duchenne muscular dystrophy.	DMD UTRN	8.35e-06	2	101	2	25859846
Pubmed	Central role for the Werner syndrome protein/poly(ADP-ribose) polymerase 1 complex in the poly(ADP-ribosyl)ation pathway after DNA damage.	WRN PARP1	8.35e-06	2	101	2	14612404
Pubmed	G-utrophin, the autosomal homologue of dystrophin Dp116, is expressed in sensory ganglia and brain.	DMD UTRN	8.35e-06	2	101	2	7731967
Pubmed	Role of dystrophin and utrophin for assembly and function of the dystrophin glycoprotein complex in non-muscle tissue.	DMD UTRN	8.35e-06	2	101	2	16710609
Pubmed	Nonclinical Exon Skipping Studies with 2'-O-Methyl Phosphorothioate Antisense Oligonucleotides in mdx and mdx-utrn-/- Mice Inspired by Clinical Trial Results.	DMD UTRN	8.35e-06	2	101	2	30672725
Pubmed	Talin, vinculin and DRP (utrophin) concentrations are increased at mdx myotendinous junctions following onset of necrosis.	DMD UTRN	8.35e-06	2	101	2	7962191
Pubmed	p120RasGAP Protein Mediates Netrin-1 Protein-induced Cortical Axon Outgrowth and Guidance.	RASA1 DCC	8.35e-06	2	101	2	26710849
Pubmed	Does utrophin expression in muscles of mdx mice during postnatal development functionally compensate for dystrophin deficiency?	DMD UTRN	8.35e-06	2	101	2	8021701
Pubmed	Correlation of Utrophin Levels with the Dystrophin Protein Complex and Muscle Fibre Regeneration in Duchenne and Becker Muscular Dystrophy Muscle Biopsies.	DMD UTRN	8.35e-06	2	101	2	26974331
Pubmed	Androgen receptor agonists increase lean mass, improve cardiopulmonary functions and extend survival in preclinical models of Duchenne muscular dystrophy.	DMD UTRN	8.35e-06	2	101	2	28453658
Pubmed	A quantitative study of bioenergetics in skeletal muscle lacking utrophin and dystrophin.	DMD UTRN	8.35e-06	2	101	2	11801396
Pubmed	Apo-dystrophin-1 and apo-dystrophin-2, products of the Duchenne muscular dystrophy locus: expression during mouse embryogenesis and in cultured cell lines.	DMD UTRN	8.35e-06	2	101	2	7987307
Pubmed	Comparative analysis of the human dystrophin and utrophin gene structures.	DMD UTRN	8.35e-06	2	101	2	11861579
Pubmed	Distinct mechanical properties in homologous spectrin-like repeats of utrophin.	DMD UTRN	8.35e-06	2	101	2	30914715
Pubmed	Comparison of skeletal muscle pathology and motor function of dystrophin and utrophin deficient mouse strains.	DMD UTRN	8.35e-06	2	101	2	22284942
Pubmed	Haploinsufficiency of utrophin gene worsens skeletal muscle inflammation and fibrosis in mdx mice.	DMD UTRN	8.35e-06	2	101	2	17889902
Pubmed	Matricellular Protein CCN5 Gene Transfer Ameliorates Cardiac and Skeletal Dysfunction in mdx/utrn (±) Haploinsufficient Mice by Reducing Fibrosis and Upregulating Utrophin Expression.	DMD UTRN	8.35e-06	2	101	2	35557546
Pubmed	Characterization of the Ang/Tie2 Signaling Pathway in the Diaphragm Muscle of DMD Mice.	DMD UTRN	8.35e-06	2	101	2	37626761
Pubmed	Molecular heterogeneity of the dystrophin-associated protein complex in the mouse kidney nephron: differential alterations in the absence of utrophin and dystrophin.	DMD UTRN	8.35e-06	2	101	2	15565469
Pubmed	The N- and C-Terminal Domains Differentially Contribute to the Structure and Function of Dystrophin and Utrophin Tandem Calponin-Homology Domains.	DMD UTRN	8.35e-06	2	101	2	26516677
Pubmed	Assessment of cardiac function in three mouse dystrophinopathies by magnetic resonance imaging.	DMD UTRN	8.35e-06	2	101	2	22209498
Pubmed	A Protocol for Simultaneous In Vivo Imaging of Cardiac and Neuroinflammation in Dystrophin-Deficient MDX Mice Using [18F]FEPPA PET.	DMD UTRN	8.35e-06	2	101	2	37108685
Pubmed	Prevention of the dystrophic phenotype in dystrophin/utrophin-deficient muscle following adenovirus-mediated transfer of a utrophin minigene.	DMD UTRN	8.35e-06	2	101	2	10694796
Pubmed	Enhanced currents through L-type calcium channels in cardiomyocytes disturb the electrophysiology of the dystrophic heart.	DMD UTRN	8.35e-06	2	101	2	24337461
Pubmed	Activation of calcineurin and stress activated protein kinase/p38-mitogen activated protein kinase in hearts of utrophin-dystrophin knockout mice.	DMD UTRN	8.35e-06	2	101	2	11297940
Pubmed	Rescue of severely affected dystrophin/utrophin-deficient mice through scAAV-U7snRNA-mediated exon skipping.	DMD UTRN	8.35e-06	2	101	2	22388933
Pubmed	Functional correction in mouse models of muscular dystrophy using exon-skipping tricyclo-DNA oligomers.	DMD UTRN	8.35e-06	2	101	2	25642938
Pubmed	Satellite cells and utrophin are not directly correlated with the degree of skeletal muscle damage in mdx mice.	DMD UTRN	8.35e-06	2	101	2	15703201
Pubmed	Utrophin suppresses low frequency oscillations and coupled gating of mechanosensitive ion channels in dystrophic skeletal muscle.	DMD UTRN	8.35e-06	2	101	2	25941878
Pubmed	Duchenne muscular dystrophy and the neuromuscular junction: the utrophin link.	DMD UTRN	8.35e-06	2	101	2	9297964
Pubmed	SERCA1 overexpression minimizes skeletal muscle damage in dystrophic mouse models.	DMD UTRN	8.35e-06	2	101	2	25652448
Pubmed	Utrophin Compensates dystrophin Loss during Mouse Spermatogenesis.	DMD UTRN	8.35e-06	2	101	2	28785010
Pubmed	Restoration of all dystrophin protein interactions by functional domains in trans does not rescue dystrophy.	DMD UTRN	8.35e-06	2	101	2	16307000
Pubmed	Expression of the dystrophin isoform Dp116 preserves functional muscle mass and extends lifespan without preventing dystrophy in severely dystrophic mice.	DMD UTRN	8.35e-06	2	101	2	21949353
Pubmed	Dystrophin and utrophin "double knockout" dystrophic mice exhibit a spectrum of degenerative musculoskeletal abnormalities.	DMD UTRN	8.35e-06	2	101	2	23097179
Pubmed	The role of utrophin and Dp71 for assembly of different dystrophin-associated protein complexes (DPCs) in the choroid plexus and microvasculature of the brain.	DMD UTRN	8.35e-06	2	101	2	15501597
Pubmed	Enhanced expression of the alpha 7 beta 1 integrin reduces muscular dystrophy and restores viability in dystrophic mice.	DMD UTRN	8.35e-06	2	101	2	11257121
Pubmed	Assessing the association of common genetic variants in EPHB4 and RASA1 with phenotype severity in familial cerebral cavernous malformation.	EPHB4 RASA1	8.35e-06	2	101	2	34491620
Pubmed	Systemic human minidystrophin gene transfer improves functions and life span of dystrophin and dystrophin/utrophin-deficient mice.	DMD UTRN	8.35e-06	2	101	2	18973234
Pubmed	Renin-angiotensin-aldosterone system inhibitors improve membrane stability and change gene-expression profiles in dystrophic skeletal muscles.	DMD UTRN	8.35e-06	2	101	2	27881412
Pubmed	Dystrophins, utrophins, and associated scaffolding complexes: role in mammalian brain and implications for therapeutic strategies.	DMD UTRN	8.35e-06	2	101	2	20625423
Pubmed	Utrophin influences mitochondrial pathology and oxidative stress in dystrophic muscle.	DMD UTRN	8.35e-06	2	101	2	29065908
Pubmed	Stabilization of the cardiac sarcolemma by sarcospan rescues DMD-associated cardiomyopathy.	DMD UTRN	8.35e-06	2	101	2	31039133
Pubmed	Developmentally regulated expression and localization of dystrophin and utrophin in the human fetal brain.	DMD UTRN	8.35e-06	2	101	2	11796130
Pubmed	Dystrophin and dystrophin-related protein in the brains of normal and mdx mice.	DMD UTRN	8.35e-06	2	101	2	8159184
Pubmed	Dystrophin and utrophin: genetic analyses of their role in skeletal muscle.	DMD UTRN	8.35e-06	2	101	2	10679963
Pubmed	TAT-μUtrophin mitigates the pathophysiology of dystrophin and utrophin double-knockout mice.	DMD UTRN	8.35e-06	2	101	2	21565990
Pubmed	Generation and characterization of transgenic mice with the full-length human DMD gene.	DMD UTRN	8.35e-06	2	101	2	18083704
Pubmed	Dystrophin and dystrophin-related protein (utrophin) distribution in normal and dystrophin-deficient skeletal muscles.	DMD UTRN	8.35e-06	2	101	2	8186702
Pubmed	Contemporary cardiac issues in Duchenne muscular dystrophy. Working Group of the National Heart, Lung, and Blood Institute in collaboration with Parent Project Muscular Dystrophy.	DMD UTRN	8.35e-06	2	101	2	25940966
Pubmed	Cardiac dysfunction and pathology in the dystrophin and utrophin-deficient mouse during development of dilated cardiomyopathy.	DMD UTRN	8.35e-06	2	101	2	22266080
Pubmed	Postnatal overexpression of the CT GalNAc transferase inhibits muscular dystrophy in mdx mice without altering muscle growth or neuromuscular development: evidence for a utrophin-independent mechanism.	DMD UTRN	8.35e-06	2	101	2	17300937
Pubmed	Early treatment with lisinopril and spironolactone preserves cardiac and skeletal muscle in Duchenne muscular dystrophy mice.	DMD UTRN	8.35e-06	2	101	2	21768542
Pubmed	Social stress is lethal in the mdx model of Duchenne muscular dystrophy.	DMD UTRN	8.35e-06	2	101	2	32192914
Pubmed	Metabolic remodeling of dystrophic skeletal muscle reveals biological roles for dystrophin and utrophin in adaptation and plasticity.	DMD UTRN	8.35e-06	2	101	2	33359740
Pubmed	Utrophin regulates modal gating of mechanosensitive ion channels in dystrophic skeletal muscle.	DMD UTRN	8.35e-06	2	101	2	24879867
Pubmed	Increased vulnerability to kainate-induced seizures in utrophin-knockout mice.	DMD UTRN	8.35e-06	2	101	2	12028357
Pubmed	Excitation-contraction coupling alterations in mdx and utrophin/dystrophin double knockout mice: a comparative study.	DMD UTRN	8.35e-06	2	101	2	20130206
Pubmed	Analysis of gene expression differences between utrophin/dystrophin-deficient vs mdx skeletal muscles reveals a specific upregulation of slow muscle genes in limb muscles.	DMD UTRN	8.35e-06	2	101	2	16525850
Pubmed	Distribution of dystrophin- and utrophin-associated protein complexes during activation of human neutrophils.	DMD UTRN	8.35e-06	2	101	2	20434517
Pubmed	Plasma lipidomic analysis shows a disease progression signature in mdx mice.	DMD UTRN	8.35e-06	2	101	2	34155298
Pubmed	Dystrophic changes in extraocular muscles after gamma irradiation in mdx:utrophin(+/-) mice.	DMD UTRN	8.35e-06	2	101	2	24466085
Pubmed	The Angiotensin Converting Enzyme Inhibitor Lisinopril Improves Muscle Histopathology but not Contractile Function in a Mouse Model of Duchenne Muscular Dystrophy.	DMD UTRN	8.35e-06	2	101	2	27110493
Pubmed	Rapid depletion of muscle progenitor cells in dystrophic mdx/utrophin-/- mice.	DMD UTRN	8.35e-06	2	101	2	24781208
Pubmed	Isolation and characterization of a genomic clone from the murine utrophin locus.	DMD UTRN	8.35e-06	2	101	2	8268660
Pubmed	Characterization of neuromuscular synapse function abnormalities in multiple Duchenne muscular dystrophy mouse models.	DMD UTRN	8.35e-06	2	101	2	27037492
Pubmed	Improvement in survival and muscle function in an mdx/utrn(-/-) double mutant mouse using a human retinal dystrophin transgene.	DMD UTRN	8.35e-06	2	101	2	16487708
Pubmed	Voltage-gated ion channel dysfunction precedes cardiomyopathy development in the dystrophic heart.	DMD UTRN	8.35e-06	2	101	2	21677768
Pubmed	Increased frequency of multiradial chromosome structures in mouse embryonic fibroblasts lacking functional Werner syndrome protein and poly(ADP-ribose) polymerase-1.	WRN PARP1	8.35e-06	2	101	2	15642393
Pubmed	Consequences of the combined deficiency in dystrophin and utrophin on the mechanical properties and myosin composition of some limb and respiratory muscles of the mouse.	DMD UTRN	8.35e-06	2	101	2	9713852
Pubmed	Activation of alpha-diacylglycerol kinase is critical for the mitogenic properties of anaplastic lymphoma kinase.	DGKA ALK	8.35e-06	2	101	2	15928040
Pubmed	Skeletal muscle fibrosis in the mdx/utrn+/- mouse validates its suitability as a murine model of Duchenne muscular dystrophy.	DMD UTRN	8.35e-06	2	101	2	25607927
Pubmed	Mineralocorticoid receptor antagonists improve membrane integrity independent of muscle force in muscular dystrophy.	NR3C2 DMD	8.35e-06	2	101	2	30759207
Pubmed	Developmental studies of dystrophin-positive fibers in mdx, and DRP localization.	DMD UTRN	8.35e-06	2	101	2	8433092
Pubmed	Second-generation compound for the modulation of utrophin in the therapy of DMD.	DMD UTRN	8.35e-06	2	101	2	25935002
Pubmed	Physical and functional interaction of the Werner syndrome protein with poly-ADP ribosyl transferase.	WRN PARP1	8.35e-06	2	101	2	14596914
Pubmed	Utrophin deficiency worsens cardiac contractile dysfunction present in dystrophin-deficient mdx mice.	DMD UTRN	8.35e-06	2	101	2	16024571
Pubmed	Utility of dystrophin and utrophin staining in childhood muscular dystrophy.	DMD UTRN	8.35e-06	2	101	2	16295426
Pubmed	Dystrophin is a microtubule-associated protein.	DMD UTRN	8.35e-06	2	101	2	19651889
Pubmed	Skeletal muscle-specific expression of a utrophin transgene rescues utrophin-dystrophin deficient mice.	DMD UTRN	8.35e-06	2	101	2	9590295
Pubmed	Utrophin haploinsufficiency does not worsen the functional performance, resistance to eccentric contractions and force production of dystrophic mice.	DMD UTRN	8.35e-06	2	101	2	29879154
Pubmed	Identification of Dp71 isoforms in the platelet membrane cytoskeleton. Potential role in thrombin-mediated platelet adhesion.	DMD UTRN	8.35e-06	2	101	2	12370193
Pubmed	Longitudinal metabolomic analysis of plasma enables modeling disease progression in Duchenne muscular dystrophy mouse models.	DMD UTRN	8.35e-06	2	101	2	32025735
Pubmed	Lifelong quercetin enrichment and cardioprotection in Mdx/Utrn+/- mice.	DMD UTRN	8.35e-06	2	101	2	27836895
Pubmed	Capillary Malformation-Arteriovenous Malformation Syndrome	EPHB4 RASA1	8.35e-06	2	101	2	21348050
Pubmed	BGP-15 Improves Aspects of the Dystrophic Pathology in mdx and dko Mice with Differing Efficacies in Heart and Skeletal Muscle.	DMD UTRN	8.35e-06	2	101	2	27750047
Pubmed	Prevention of dystrophin-deficient cardiomyopathy in twenty-one-month-old carrier mice by mosaic dystrophin expression or complementary dystrophin/utrophin expression.	DMD UTRN	8.35e-06	2	101	2	17967782
Pubmed	Diaphragm rescue alone prevents heart dysfunction in dystrophic mice.	DMD UTRN	8.35e-06	2	101	2	21062902
Pubmed	Automatic and unbiased segmentation and quantification of myofibers in skeletal muscle.	IFT88 DMD	8.35e-06	2	101	2	34083673
Pubmed	Dystrophin and dystrophin-related protein in the central nervous system of normal controls and Duchenne muscular dystrophy.	DMD UTRN	8.35e-06	2	101	2	8171962
Pubmed	Similar efficacy from specific and non-specific mineralocorticoid receptor antagonist treatment of muscular dystrophy mice.	DMD UTRN	8.35e-06	2	101	2	27822449
Pubmed	Micro-dystrophin gene therapy prevents heart failure in an improved Duchenne muscular dystrophy cardiomyopathy mouse model.	DMD UTRN	8.35e-06	2	101	2	33651713
Pubmed	Thermodynamic stability, unfolding kinetics, and aggregation of the N-terminal actin-binding domains of utrophin and dystrophin.	DMD UTRN	8.35e-06	2	101	2	22275054
Pubmed	NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation.	DMD UTRN	8.35e-06	2	101	2	27798264
Pubmed	Glycine administration attenuates progression of dystrophic pathology in prednisolone-treated dystrophin/utrophin null mice.	DMD UTRN	8.35e-06	2	101	2	31506484
GeneFamily	Ring finger proteins	TRIM73 RNF19B RFPL1 MID1 MARCHF11 LNX1 TRIM74	1.32e-04	275	74	7	58
GeneFamily	Fibronectin type III domain containing	EPHB4 IL12RB2 DCC MID1 EGFLAM	5.02e-04	160	74	5	555
GeneFamily	Dyneins, axonemal	DNAH3 DNAH9	2.16e-03	17	74	2	536
GeneFamily	Basic leucine zipper proteins\|BTB domain containing	ZBTB26 BTBD9 KLHL32 KLHL36	2.22e-03	134	74	4	861
GeneFamily	Zinc fingers ZZ-type\|Lysine acetyltransferases	DMD UTRN	2.42e-03	18	74	2	91
Coexpression	GSE11386_NAIVE_VS_MEMORY_BCELL_DN	RAPGEF4 CASD1 MDN1 ZKSCAN3 NLRC5 UTRN GABBR1	2.71e-06	158	101	7	M372
CoexpressionAtlas	alpha beta T cells, T.8Nve.PP, TCRb+ CD8+ CD44low CD62L high, Peyer's Patch, avg-1	SMG1 RAPGEF4 DGKA WDR43 MDN1 CD226 IL21R NLRC5 HERC1 UTRN	2.40e-06	336	94	10	GSM538413_500
CoexpressionAtlas	alpha beta T cells, T.4.Pa.BDC, 4+ 8- BDC+, Pancreas, avg-2	RASA1 RAPGEF4 DGKA MDN1 CD226 IL21R NLRC5 UTRN SEC14L1	1.51e-05	328	94	9	GSM605756_500
CoexpressionAtlas	alpha beta T cells, T.4Mem.Sp, 4+ 8- 25- 44hi 122lo, Spleen, avg-3	IL12RB2 RASA1 RAPGEF4 DGKA CD226 IL21R NLRC5 UTRN KIF11	2.15e-05	343	94	9	GSM538365_500
CoexpressionAtlas	kidney_adult_Podocyte_MafB_k-means-cluster#3_top-relative-expression-ranked_500	KLHL32 ACKR3	5.80e-05	3	94	2	gudmap_kidney_adult_Podocyte_MafB_k3_500
CoexpressionAtlas	DevelopingLowerUrinaryTract_e14.5_ bladder_emap-30872_k-means-cluster#1_top-relative-expression-ranked_500	SMG1 RAPGEF4 WRN LIMS1 FAR2 MED13 KIF11	7.55e-05	231	94	7	gudmap_developingLowerUrinaryTract_e14.5_ bladder_500_k1
CoexpressionAtlas	alpha beta T cells, T.8Nve.PP, TCR+ CD8+ CD44low CD62Lhigh, Peyer's Patch, avg-1	SMG1 RAPGEF4 DGKA MDN1 CD226 IL21R NLRC5 UTRN	8.26e-05	317	94	8	GSM538412_500
CoexpressionAtlas	alpha beta T cells, NKT.4-.Sp, TCRbeta+ aGalCer tet+ CD4-, Spleen, avg-3	IL12RB2 RASA1 SLC27A6 DGKA GSAP CD226 NLRC5 UTRN	1.11e-04	331	94	8	GSM538329_500
CoexpressionAtlas	alpha beta T cells, T.8SP24int.Th, 4- 8+ TCRhi 24int, Thymus, avg-3	SLC27A6 RAPGEF4 DGKA CD226 IL21R NLRC5 UTRN KIF11	1.31e-04	339	94	8	GSM399382_500
CoexpressionAtlas	alpha beta T cells, T.8SP24-.Th, 4- 8+ TCRhi 24-/lo, Thymus, avg-3	SLC27A6 RAPGEF4 DGKA CD226 IL21R NLRC5 UTRN KIF11	1.67e-04	351	94	8	GSM399379_500
CoexpressionAtlas	alpha beta T cells, T.8Nve.PP, TCR+ CD8+ CD44low CD62Lhigh, Peyer's Patch, avg-1	RAPGEF4 DGKA CD226 UTRN	2.50e-04	69	94	4	GSM538412_100
ToppCell	COVID-19-kidney-Technical/muscle_(Mes)\|kidney / Disease (COVID-19 only), tissue and cell type	DNAH3 DCC NRXN1 CPNE4 DMD DNAH9 ALK	7.85e-08	159	101	7	5335cbcdeaf2bbd0268bbfe0e45c8c0d288e640d
ToppCell	COVID-19-kidney-Technical/muscle_(Imm)\|kidney / Disease (COVID-19 only), tissue and cell type	DNAH3 DCC NRXN1 EGFLAM DMD DNAH9 ALK	9.30e-08	163	101	7	19c28ce16a588a7f4a035c32726f6ccd67702b5b
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	USP34 SMG1 TRIM73 CD226 NLRC5 HERC1 UTRN	3.61e-07	199	101	7	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	USP34 WDR70 BTBD9 NR3C2 DMD HERC1 UTRN	3.61e-07	199	101	7	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	USP34 SMG1 RASA1 DGKA NR3C2 UTRN	1.90e-06	162	101	6	b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABR KLHL32 CCL28 CPNE4 GABBR1 SEC14L1	1.97e-06	163	101	6	8dc0128eeede933537e3bcc5d6ec0322711552f3
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABR KLHL32 CCL28 CPNE4 GABBR1 SEC14L1	1.97e-06	163	101	6	fd243ca223079033be480a24817a399f281fa4d4
ToppCell	facs-Lung-3m-Mesenchymal-myofibroblast-pericyte_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CST11 GPRC6A ARHGEF17 RAD51AP2 NRXN1 EGFLAM	2.97e-06	175	101	6	2a53d4f140d5ab096efe8118d8aa351db7838b49
ToppCell	facs-Lung-3m-Mesenchymal-myofibroblast-pericyte_cell-pericyte\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CST11 GPRC6A ARHGEF17 RAD51AP2 NRXN1 EGFLAM	2.97e-06	175	101	6	fb91a45763e4c48d993094a13088ffc19f1e2574
ToppCell	3'-GW_trimst-1.5-SmallIntestine-Neuronal-neuron_precursor-cycling_neuroblast\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	NCAPD3 TMPRSS5 BTBD9 RAD51AP2 PARP1 NRXN1	3.72e-06	182	101	6	e6968e0bd9cef92052d04ac54e2dd746b37623f6
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	USP34 SMG1 BTBD9 HERC1 UTRN MED13	4.48e-06	188	101	6	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	PCW_13-14-Epithelial-Epithelial_airway-epi_proximal_progenitor1_(6)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	SLC27A6 GSAP NR3C2 DMD MAP3K21 FHIP1A	4.48e-06	188	101	6	0d86044bc340e3efb90d0022dd299873639d831c
ToppCell	PND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GPRC6A ARHGEF17 LIMS1 NRXN1 EGFLAM CNN2	5.06e-06	192	101	6	158cc5736f154da1cb3186ffbf186eae10483e48
ToppCell	PND14-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GPRC6A ARHGEF17 LIMS1 NRXN1 EGFLAM CNN2	5.06e-06	192	101	6	f4ff62ac9c53eafbe917706de9af8b2d4bded4d4
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EPHB4 TCAF2 ABR RAPGEF4 FAR2 SEC14L1	5.36e-06	194	101	6	ad6c04ad0621689e3bf4c94ccd6e60653bbd02c7
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	USP34 SMG1 TRIM73 DGKA HERC1 UTRN	5.86e-06	197	101	6	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	mild-low-quality_cells\|mild / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SMG1 TRIM73 DGKA CD226 NLRC5 UTRN	5.86e-06	197	101	6	e4331969bd911d1ebb5453f40a7057297b5389b4
ToppCell	COVID-19-kidney-Mito-rich_Int\|kidney / Disease (COVID-19 only), tissue and cell type	SLC27A6 DCC CPNE4 DMD DNAH9	1.14e-05	129	101	5	57b705106aec7bbfc587de1ccd4f2335fc44dd6f
ToppCell	COVID-19-kidney-Technical/muscle\|kidney / Disease (COVID-19 only), tissue and cell type	DNAH3 CST11 NRXN1 CPNE4 DNAH9	2.21e-05	148	101	5	0dbd87078f54ee1c2f8ec64e8bac9dfddb9c181e
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABR KLHL32 CCL28 CPNE4 GABBR1	2.93e-05	157	101	5	ec433d2fe827abdb647be4176c231b7052482b6f
ToppCell	droplet-Large_Intestine-COLON_PROXIMAL-30m-Epithelial-Lgr5+_amplifying_undifferentiated_cell\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CCL28 GLUL CPNE4 DMD MED13	4.06e-05	168	101	5	d69452e2cfeb74023b5cf3d09064d7dcad0008ec
ToppCell	COVID-19-Heart-T_cell\|COVID-19 / Disease (COVID-19 only), tissue and cell type	IL12RB2 DCC NRXN1 CD226 ALK	4.41e-05	171	101	5	b2e753e811a7639956994609f73efcdb62d04f82
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell_prolif\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EPHB4 TCAF2 RAPGEF4 FAR2 SEC14L1	4.54e-05	172	101	5	c056d44e2e130ceccadfcdceb192a7f095d779c8
ToppCell	PND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GPRC6A ARHGEF17 LIMS1 NRXN1 EGFLAM	4.66e-05	173	101	5	f9d6e892d66f9b94e4d5beb9f5dec9b606bc868a
ToppCell	PND28-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte\|PND28 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GPRC6A ARHGEF17 LIMS1 NRXN1 EGFLAM	4.66e-05	173	101	5	cbd65dd5b01cc959e3ccbc89330ddd0122296ea3
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GPRC6A ARHGEF17 LIMS1 NRXN1 EGFLAM	5.48e-05	179	101	5	56db12467b445f2b8ef92af50779eeab10413eb2
ToppCell	10x5'-Liver-Lymphocytic_T_CD4-T_CD4/CD8\|Liver / Manually curated celltypes from each tissue	USP34 SMG1 DGKA HERC1 TRIM74	5.78e-05	181	101	5	f2315414e714ac86211546a935660c4be6e85f1b
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-nan\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TMC2 ARHGEF17 NRXN1 MSLNL EGFLAM	5.93e-05	182	101	5	c84f44391932080df31c8765e363c3dff64b2bd1
ToppCell	Control-Myeloid-DC1\|Myeloid / Condition, Lineage and Cell class	TCAF2 RAB33A CD226 DMD FHIP1A	6.25e-05	184	101	5	b5c1f57f0356969cfb0e1dac764684fc5583bc04
ToppCell	5'-Adult-Distal_Rectal-Mesenchymal-fibroblastic-mLN_Stroma_(FMO2+)\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	AOX1 ARHGEF17 ACKR3 GLUL EGFLAM	6.41e-05	185	101	5	9faa35ceb89ccd2979072286f063687c9f846ce3
ToppCell	P15-Mesenchymal-developing_mesenchymal_cell-mesenchymal_myogenic_precursor_(Axin2+)\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	GPRC6A ARHGEF17 LIMS1 NRXN1 EGFLAM	6.41e-05	185	101	5	b1e84228c95be8ccf7c3c1afb66b71ffb93cf61e
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	GSAP BTBD9 NR3C2 DMD FHIP1A	6.57e-05	186	101	5	2ea5ff14861e5f91d0e6a5767c403a24045d715c
ToppCell	P15-Mesenchymal-developing_mesenchymal_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	GPRC6A ARHGEF17 LIMS1 NRXN1 CNN2	6.57e-05	186	101	5	db9b67066fc003c7995ec205d15176bf40c97add
ToppCell	droplet-Spleen-nan-3m\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMG1 RAPGEF4 DGKA CD226 UTRN	6.57e-05	186	101	5	26f1e9930adf2fe4af0819e56f69915bd8330e4a
ToppCell	PCW_10-12-Epithelial-Epithelial_alveolar-distal-epi_SOX9^high_Etv5^high_distal_(10)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	GSAP NR3C2 CPNE4 MAP3K21 FHIP1A	6.74e-05	187	101	5	db2974e2e87ac9f1c2407a371d5ed89af09fc9b7
ToppCell	PCW_10-12-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)\|PCW_10-12 / Celltypes from embryonic and fetal-stage human lung	GSAP DMD MAP3K21 LNX1 FHIP1A	6.91e-05	188	101	5	3cfba3addcc9058f4ec31ad96261f79988f551a0
ToppCell	COVID-19-kidney-VWF+PLVAP+VCAM1+EC\|COVID-19 / Disease (COVID-19 only), tissue and cell type	EPHB4 TCAF2 RAPGEF4 MID1 SEC14L1	7.09e-05	189	101	5	c121817ddad164e9cfe382c43d0cbc9215508d02
ToppCell	PND03-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GPRC6A ARHGEF17 LIMS1 NRXN1 EGFLAM	7.09e-05	189	101	5	ca3a04c202afc32aa11d17154066ef7dc6d01405
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GPRC6A ARHGEF17 LIMS1 NRXN1 EGFLAM	7.27e-05	190	101	5	7e4d80a3a7f83b6a50f1d0fe82fb6c242c39d5b0
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ARHGEF17 LIMS1 NRXN1 EGFLAM DMD	7.27e-05	190	101	5	1004e89d99c9d46c78b7d3532d8d4aadb81a96fd
ToppCell	Fetal_29-31_weeks-Immune-T_lymphocyte-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	TCAF2 DGKA CD226 IL21R NLRC5	7.27e-05	190	101	5	2a8de1cf27a9ebc3825cf9e7a489ecd064dfc7f9
ToppCell	PND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GPRC6A ARHGEF17 LIMS1 NRXN1 EGFLAM	7.27e-05	190	101	5	7fec459cd2ad12c2923a03d098289337c0a4c1d3
ToppCell	PND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	ARHGEF17 LIMS1 NRXN1 EGFLAM DMD	7.27e-05	190	101	5	10b02c62e72bfea9767e3e751011436925da823e
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial-Ascending_Vasa_Recta_Endothelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EPHB4 ABR RAPGEF4 FAR2 SEC14L1	7.45e-05	191	101	5	f663131a4810584c5854bd64ee7991a237b7707f
ToppCell	PCW_13-14-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)\|PCW_13-14 / Celltypes from embryonic and fetal-stage human lung	GSAP DMD MAP3K21 LNX1 FHIP1A	7.45e-05	191	101	5	63aa671837b79d2feb7ed1e67712cc01caf72bef
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D062\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	GSAP BTBD9 MALRD1 NR3C2 FHIP1A	7.64e-05	192	101	5	29f49f00770c991b5f27e4cb701dd2d2d6cb7178
ToppCell	PCW_07-8.5-Epithelial-Epithelial_neuroendo-epi_NE_progenitor_(7)\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	RAPGEF4 GSAP DMD MAP3K21 FHIP1A	7.64e-05	192	101	5	b99f8236ef4ccdc75c02abea381cae6453205f6f
ToppCell	IPF-Epithelial-Ciliated\|Epithelial / Disease state, Lineage and Cell class	DNAH3 KLHL32 IFT88 DMD DNAH9	7.82e-05	193	101	5	ad58f5080e0ba65c845056ea6b79037b636e9c64
ToppCell	severe-low-quality_cells\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SMG1 DGKA HERC1 UTRN ALK	7.82e-05	193	101	5	9337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell	CF-Lymphoid\|CF / Disease state, Lineage and Cell class	WRN WDR43 PARP1 MDN1 IL21R	7.82e-05	193	101	5	11de07d13a7da223990b56fa89ba7fc1c3dd0122
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	EPHB4 RAPGEF4 FAR2 UTRN SEC14L1	7.82e-05	193	101	5	287e756d5fd3bd2931c168da24beaa0d02a350ae
ToppCell	PCW_07-8.5-Epithelial-Epithelial_neuroendo\|PCW_07-8.5 / Celltypes from embryonic and fetal-stage human lung	RAPGEF4 GSAP KLHL32 NRXN1 FHIP1A	8.02e-05	194	101	5	b30379f8dc41c86c746af9930541fbb4819d8fa0
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAPGEF4 KLHL32 RAD51AP2 NRXN1 HERC1	8.21e-05	195	101	5	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RAPGEF4 KLHL32 RAD51AP2 NRXN1 HERC1	8.21e-05	195	101	5	7796ea9247f4c63762f0de8490fed08b9717fa23
ToppCell	Bronchial-NucSeq\|Bronchial / Cell types per location group and 10X technology with lineage, and cell group designations	WDR70 BTBD9 NR3C2 DMD FHIP1A	8.41e-05	196	101	5	ab53c742866945545a92e2e61850d63c80d9a2a6
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABR RAPGEF4 FAR2 UTRN SEC14L1	8.41e-05	196	101	5	8ad8efb631164b46f0c082572270188e5ead20bf
ToppCell	renal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	EPHB4 RAPGEF4 FAR2 UTRN SEC14L1	8.41e-05	196	101	5	ab7be3858deabbd1fc44e8b9da8ff49a50bf1fb1
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EPHB4 ABR RAPGEF4 FAR2 SEC14L1	8.41e-05	196	101	5	8f2031b1a9232c389517fbf3c29f47f9468b0077
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EPHB4 ABR RAPGEF4 FAR2 SEC14L1	8.41e-05	196	101	5	48b4a9cea97a55190217deaf51bf867608c5a9a7
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ABR RAPGEF4 FAR2 UTRN SEC14L1	8.41e-05	196	101	5	b8f89a50114932c08fc5daac4b549adfe9df8e66
ToppCell	renal_medulla_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABR RAPGEF4 FAR2 UTRN SEC14L1	8.41e-05	196	101	5	9606ea7e42f707e69ea891b3521037613b9675f5
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	EPHB4 ABR RAPGEF4 FAR2 SEC14L1	8.41e-05	196	101	5	473980c827443464d08a0be28c53e3536369b12a
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial-blood_vessel_endothelial_cell_of_kidney-arteriolar_vasa-recta_endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ABR RAPGEF4 FAR2 UTRN SEC14L1	8.41e-05	196	101	5	145fcf73deba9638b391a1af6c39fa205dc9829f
ToppCell	renal_medulla_nuclei-Adult_normal_reference-Endothelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ABR RAPGEF4 FAR2 UTRN SEC14L1	8.41e-05	196	101	5	d0ff1082898d2db47c88d2678466514e9e9193d3
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABR RAPGEF4 FAR2 UTRN SEC14L1	8.83e-05	198	101	5	07701c73137947ed4a27e225975329235bbb8734
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABR RAPGEF4 FAR2 UTRN SEC14L1	8.83e-05	198	101	5	31ba87552be97c9b78c9e82f98e96699ccb19824
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABR RAPGEF4 FAR2 UTRN SEC14L1	8.83e-05	198	101	5	fa84bf8533d1b91d2c2bcf06b710670605072b89
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Endothelial-blood_vessel_endothelial_cell_of_kidney-capillary-immature_endothelial_cell-Peritubular_Capilary_Endothelial_Cell_\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ABR RAPGEF4 FAR2 UTRN SEC14L1	8.83e-05	198	101	5	0a172c6d997c7cfbad34b56e80121bd104dee67d
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Gen_Cap\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	EPHB4 USP34 RAPGEF4 UTRN SEC14L1	9.25e-05	200	101	5	dccec522ab0d7fff62ad6273b02aa9022dbbb8eb
Disease	Colorectal Carcinoma	DNAH3 WRN DCC PARP1 CD226 ACKR3 ZKSCAN3 NR3C2 DMD TSKS	9.77e-05	702	96	10	C0009402
Disease	androsterone sulfate measurement	FAM200A DCC ALK	1.70e-04	33	96	3	EFO_0021117
Disease	pro-hydroxy-pro measurement	NR3C2 ALK	1.22e-03	16	96	2	EFO_0021132
Disease	primary autosomal recessive microcephaly (is_implicated_in)	NCAPD3 NUP37	1.22e-03	16	96	2	DOID:0070296 (is_implicated_in)
Disease	age at first sexual intercourse measurement	BCORL1 DCC NRXN1 RAD54B CPNE4 UTRN	1.60e-03	383	96	6	EFO_0009749
Disease	temporal horn of lateral ventricle volume measurement	RAPGEF4 NRXN1 UTRN	1.69e-03	72	96	3	EFO_0010333
Disease	sensorineural hearing loss (implicated_via_orthology)	LNX1 DNAH9	1.73e-03	19	96	2	DOID:10003 (implicated_via_orthology)
Disease	muscular dystrophy (implicated_via_orthology)	DMD UTRN	2.11e-03	21	96	2	DOID:9884 (implicated_via_orthology)
Disease	Colorectal Neoplasms	DCC PARP1 CD226 ACKR3 ZKSCAN3	2.14e-03	277	96	5	C0009404
Disease	feeling miserable measurement	TMPRSS5 DCC GABBR1	2.21e-03	79	96	3	EFO_0009598
Disease	chronic widespread pain	WDR70 CD226	2.53e-03	23	96	2	EFO_0010099
Disease	suicidal ideation, suicide behaviour	TMPRSS5 DCC	2.76e-03	24	96	2	EFO_0004320, EFO_0007623

Protein segments in the cluster

Peptide	Gene	Start	Entry
NLCPKVQQWDSQVTM	ABR	156	Q12979
LKWLHAQQVQQHCPM	ANAPC11	61	Q9NYG5
WNCILMRNHEIIQQP	ARSH	221	Q5FYA8
RICVSPHNHTVKQWM	CCL28	71	Q9NRJ3
LNCTAFSIQWKMPRH	EGFLAM	46	Q63HQ2
DPTWQEMLNHATCKV	SH3BP5L	166	Q7L8J4
EKLPQVTRSWHNYMC	ACTL6A	241	O96019
WTPLNTQMSKQVDCS	BCORL1	141	Q5H9F3
LKELNTQWDHMCQQV	DMD	1131	P11532
NVEMQWTTCQKPETT	CST11	86	Q9H112
KPIWCQNHRNVGMAC	C3AR1	126	Q16581
SCVPDWKELMNRQAH	FAM200A	556	Q8TCP9
SCQKLIGRHWNEQML	AOX1	476	Q06278
MSCPQQVVNVENWAH	RAD51AP2	711	Q09MP3
NSLVMPRPDKNHQWV	RAD54B	261	Q9Y620
TNLKMWIQECNGHAV	RAB33A	126	Q14088
VQHKWPTNTTMRTRV	RASA1	881	P20936
CMVKTQTPNRKEWVT	PARP1	321	P09874
VRHCMQTWHAQQKVG	ARHGEF17	1131	Q96PE2
NPCNWHKMGVQVLAT	FAR2	311	Q96K12
IMRTNTWFQCKEPKN	MMP27	456	Q9H306
SLHVRPQTNCIIMSW	DCC	731	P43146
DPRCKQWIKVASMNQ	KLHL36	371	Q8N4N3
CRMRKQDHLWQQSTT	MDN1	4371	Q9NU22
MVTKCPNNSGQSWQR	NR3C2	906	P08235
PTSLHQLMLDCWQKD	EPHB4	846	P54760
PQLEHCSSRKMNTWL	GABBR1	756	Q9UBS5
QTHSQELCKLMNLWT	KIF11	716	P52732
CMWETPIAQAKHAIQ	HERC1	1991	Q15751
WNSIPVQEQMGCLLH	IL12RB2	541	Q99665
LQNRWRGMKNEEHCP	LINC02901	71	Q4VX62
KAWLMNSIQSNCSVP	NXF5	26	Q9H1B4
MLLWQCPTQGTRKNH	FAM223A	51	Q8IWN6
PWMQTPCTIKITHKN	DGKA	701	P23743
QPCQVLWLTVMREQK	LNX1	346	Q8TBB1
CWMSPHQIQTIHPQE	MSLNL	441	Q96KJ4
KPLNDNQWHNVMISR	NRXN1	981	Q9ULB1
SEQVPLMSAHWCLKN	NUP37	206	Q8NFH4
MALQDVCKWQSPDTQ	PSMB11	1	A5LHX3
QRPNMACTWSVKEVA	NSUN6	331	Q8TEA1
LWNNPIPCDMAQHLK	NLRC5	1831	Q86WI3
QVMRHLKEDIWCPGN	MAB21L3	261	Q8N8X9
NNKTHWAPVRSTMCF	GPRC6A	566	Q5T6X5
RFWCQQLAMPQHIKI	ITCH	536	Q96J02
HMTQDQSLQPSWTKR	MALRD1	81	Q5VYJ5
DKRTCIPMNHLWPNQ	OGDH	696	Q02218
QKICRLWDHPMSSNI	GSAP	761	A4D1B5
LIPCNHMMLSQRWAV	FHIP1A	411	Q05DH4
VPIWCKNSQGQRVMV	FBH1	576	Q8NFZ0
PTQVKWQLMVASCFR	IFT88	651	Q13099
WHPEVNGSMKQCIKV	CASD1	136	Q96PB1
ISCNPGMKDRHWQQI	DNAH3	946	Q8TD57
PCVILKMQSHGQWFE	CPNE4	46	Q96A23
QHNQWPMGELTCKVT	ACKR3	106	P25106
WTELPMCVATHQLKR	CFHR5	316	Q9BXR6
MKQPCQWQSISITLV	MARCHF11	226	A6NNE9
QMSPKHWQIQQALKR	CCDC38	226	Q502W7
NPWSLRCHKQQLSRM	IP6K1	181	Q92551
QTVICILEMWNLHPS	IL21R	31	Q9HBE5
NPQELCRCSQVSMKW	FBXL5	221	Q9UKA1
ANEKNRLNWPHMICE	DNAH9	146	Q9NYC9
KNVTLTCQPQMTWPV	CD226	146	Q15762
QQQWTMVADRTKVSC	BTBD9	506	Q96Q07
EIMCQSLTWRKQHQV	SEC14L1	296	Q92503
PWQVSIQMSRKHLCG	PRSS51	51	A0A1B0GVH4
TCKRIMDMVSNQHPW	GLUL	116	P15104
TVNMTWNKICREVPT	UTRN	2166	P46939
INHQTQTTCWDHPKM	UTRN	2831	P46939
QTTCWDHPKMTELFQ	UTRN	2836	P46939
CSMVSQKNKIRPSWQ	RFPL1	81	O75677
LVDWMMQQTPCVHSR	RAPGEF4	241	Q8WZA2
CKQIWHPNQTCDMAR	RNF19B	241	Q6ZMZ0
KLSRAPVVTHQCWMD	TCAF2	586	A6NFQ2
LMKECWQQDPHIRPS	MAP3K21	376	Q5TCX8
CANHWITTTMNLKPL	RGPD2	1101	P0DJD1
ALRSCKQHDVRPWMQ	SMG1	1381	Q96Q15
VFCQMQELPQLWHIS	SLC26A10	391	Q8NG04
LETTAQQRKCPEWMN	WRN	6	Q14191
ITCSWQNEMQKRIPH	RNASE9	166	P60153
RVIKAMNNSWHPECF	LIMS1	81	P48059
LHPWSKRNDVSMQCS	MED13	1261	Q9UHV7
IMTQCWQHQPEDRPN	ALK	1361	Q9UM73
LLMAQPRCVQIQKAW	NCAPD3	606	P42695
SVPKINRSMQNWHQL	CNN2	71	Q99439
EIRCIVMVPQWGTHQ	PRPF8	2141	Q6P2Q9
HLDTKVRCPMCWQVV	TRIM74	46	Q86UV6
RCLWHPKLNQIMVGT	WDR70	476	Q9NW82
CNSADSWMIVPNIKQ	MID1	431	O15344
DQQHPISQAVCWRSM	TMPRSS5	31	Q9H3S3
QMSHQPMHWCLNLKR	TSKS	61	Q9UJT2
RMTEHNSVKPWQQLN	TTLL2	131	Q9BWV7
MEWSGICTTQQVKHN	GTF3C4	251	Q9UKN8
CCQWLQPEAHSKEQM	ZNF446	51	Q9NWS9
TCLEQGKEPWNMKRH	ZNF430	86	Q9H8G1
CRQWLQPEMHSKEQI	ZKSCAN3	71	Q9BRR0
HLDTKVRCPMCWQVV	TRIM73	46	Q86UV7
MSRRKQTNPNKVHWD	ZNF821	1	O75541
LKVCMANISNDHWPS	TTC37	1451	Q6PGP7
PRNKLAHSWVLQNME	USP34	2651	Q70CQ2
QCWAVMSSNVPHERV	TMC2	671	Q8TDI7
QKDEPMRNEQGWCIH	SLC27A6	401	Q9Y2P4
MHTPQCEDIIQWCRR	SLC26A7	16	Q8TE54
QMSHIVERCTQALWK	ZBTB26	111	Q9HCK0
HPNSAVLMVQWLKCV	WDR43	516	Q15061
NSWAEIAPMKNCREH	KLHL32	376	Q96NJ5