Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionserpin family protein binding

CTSL CTSV

6.14e-062502GO:0097655
GeneOntologyMolecularFunctionlatrotoxin receptor activity

ADGRL1 ADGRL2

6.14e-062502GO:0016524
GeneOntologyMolecularFunctioncysteine-type carboxypeptidase activity

CTSL CTSV

3.68e-054502GO:0016807
GeneOntologyMolecularFunctionkininogen binding

CTSL CTSV

6.12e-055502GO:0030984
GeneOntologyMolecularFunctioncysteine-type exopeptidase activity

CTSL CTSV

2.73e-0410502GO:0070004
GeneOntologyBiologicalProcessmaintenance of postsynaptic specialization structure

CADM1 PRICKLE2 ADGRL3

8.90e-0617503GO:0098880
GeneOntologyBiologicalProcesssynapse assembly

CADM1 DKK1 DOCK7 PRICKLE2 ADGRL1 ADGRL2 ADGRL3

8.91e-06308507GO:0007416
GeneOntologyBiologicalProcesspostsynaptic specialization organization

CADM1 DOCK7 PRICKLE2 ADGRL3

2.63e-0571504GO:0099084
GeneOntologyBiologicalProcesssynapse organization

CADM1 DKK1 DOCK7 PRICKLE2 ADGRL1 SPG11 ACTL9 ADGRL2 ADGRL3

3.45e-05685509GO:0050808
GeneOntologyBiologicalProcessmaintenance of synapse structure

CADM1 PRICKLE2 ADGRL3

1.24e-0440503GO:0099558
GeneOntologyBiologicalProcessregulation of synapse assembly

DKK1 PRICKLE2 ADGRL1 ADGRL2 ADGRL3

1.27e-04202505GO:0051963
GeneOntologyBiologicalProcesscatagen

CTSL CTSV

2.05e-049502GO:0042637
MousePhenoperiodontal ligament necrosis

CTSL CTSV

6.45e-062362MP:0030515
MousePhenoabnormal lymph node medullary sinus morphology

CTSL CTSV

6.45e-062362MP:0011222
MousePhenodilated lymph node medullary sinus

CTSL CTSV

6.45e-062362MP:0011223
MousePhenorough coat

CTSL CTSV EPG5

3.06e-0524363MP:0010179
MousePhenofolliculitis

CTSL CTSV

6.42e-055362MP:0000376
MousePhenodental pulp necrosis

CTSL CTSV

6.42e-055362MP:0013251
MousePhenohair follicle outer root sheath hyperplasia

CTSL CTSV

6.42e-055362MP:0010688
MousePhenoenlarged thymus cortex

CTSL CTSV

6.42e-055362MP:0013593
MousePhenoamyloidosis

PSAP CTSL CTSV

9.70e-0535363MP:0000604
MousePhenoabnormal amyloid deposition

PSAP CTSL CTSV

9.70e-0535363MP:0021152
MousePhenogranulomatous inflammation

IL31RA CTSL CTSV

1.06e-0436363MP:0002500
MousePhenomitral valve regurgitation

CTSL CTSV

1.34e-047362MP:0006045
MousePhenoabnormal R wave

CTSL CTSV

1.34e-047362MP:0011919
MousePhenoincreased effector memory CD4-positive, alpha-beta T cell number

ZC3H12C CTSL CTSV

1.56e-0441363MP:0010844
MousePhenodilated piliary canal

CTSL CTSV

1.79e-048362MP:0030571
MousePhenosparse vibrissae

CTSL CTSV

1.79e-048362MP:0001283
MousePhenostereotypic behavior

PSAP CTSL CTSV ADGRL3 EPG5

2.06e-04214365MP:0001408
MousePhenoabnormal hair cycle catagen phase

CTSL CTSV

2.30e-049362MP:0008859
MousePhenoabnormal T wave

CTSL CTSV

2.30e-049362MP:0010505
MousePhenoincreased heart left atrium size

CTSL CTSV

2.30e-049362MP:0008726
MousePhenohypergranulosis

CTSL CTSV

2.30e-049362MP:0009600
MousePhenofocal dorsal hair loss

CTSL CTSV

2.30e-049362MP:0010202
MousePhenoabnormal effector memory CD4-positive, alpha-beta T cell number

ZC3H12C CTSL CTSV

2.51e-0448363MP:0012770
MousePhenoabnormal effector memory CD4-positive, alpha-beta T cell morphology

ZC3H12C CTSL CTSV

2.51e-0448363MP:0010843
MousePhenoabnormal lymph node cortex morphology

ZC3H12C CTSL CTSV

2.83e-0450363MP:0002343
MousePhenoabnormal lymph node medulla morphology

CTSL CTSV

2.86e-0410362MP:0002348
MousePhenoabnormal CD4-positive, alpha-beta memory T cell morphology

ZC3H12C CTSL CTSV

3.75e-0455363MP:0010834
MousePhenoabnormal piliary canal morphology

CTSL CTSV

4.19e-0412362MP:0030570
MousePhenothick epidermis stratum granulosum

CTSL CTSV

4.19e-0412362MP:0009599
MousePhenolymph node inflammation

CTSL CTSV

4.19e-0412362MP:0003865
MousePhenoabnormal dental pulp morphology

CTSL CTSV

4.19e-0412362MP:0013250
MousePhenoincreased CD4-positive, alpha-beta memory T cell number

ZC3H12C CTSL CTSV

4.62e-0459363MP:0010835
MousePhenoaortic valve regurgitation

CTSL CTSV

4.94e-0413362MP:0006047
MousePhenoatrioventricular valve regurgitation

CTSL CTSV

4.94e-0413362MP:0006046
MousePhenoabnormal periodontal ligament morphology

CTSL CTSV

4.94e-0413362MP:0003668
MousePhenoabnormal lysosome morphology

SPG11 CTSL CTSV

5.09e-0461363MP:0005058
MousePhenoabnormal hair texture

CTSL CTSV EPG5

5.60e-0463363MP:0002074
MousePhenoabnormal vacuole morphology

SPG11 CTSL CTSV

6.42e-0466363MP:0020851
MousePhenoabnormal astrocyte morphology

CADM1 PSAP SPG11 EPG5

6.50e-04155364MP:0002182
MousePhenoexcessive scratching

CTSL CTSV

6.63e-0415362MP:0001412
MousePhenoabnormal hair follicle outer root sheath morphology

CTSL CTSV

7.56e-0416362MP:0010684
MousePhenoabnormal dental pulp cavity morphology

CTSL CTSV

7.56e-0416362MP:0002819
MousePhenoorthokeratosis

CTSL CTSV

7.56e-0416362MP:0009675
MousePhenoshort hair

CTSL CTSV

7.56e-0416362MP:0000417
MousePhenoabnormal thymus corticomedullary boundary morphology

CTSL CTSV

8.56e-0417362MP:0009543
MousePhenogreasy coat

CTSL CTSV

8.56e-0417362MP:0003849
MousePhenoaxonal spheroids

PSAP EPG5

8.56e-0417362MP:0010047
MousePhenoabnormal CD4-positive, alpha-beta memory T cell number

ZC3H12C CTSL CTSV

8.97e-0474363MP:0012769
MousePhenosemilunar valve regurgitation

CTSL CTSV

9.61e-0418362MP:0006049
MousePhenoabnormal external auditory canal morphology

CTSL CTSV

1.07e-0319362MP:0006033
MousePhenoabnormal hair follicle orientation

CTSL CTSV

1.07e-0319362MP:0000383
MousePhenodelayed hair appearance

CTSL CTSV

1.07e-0319362MP:0000422
MousePhenochronic inflammation

IL31RA CTSL CTSV

1.08e-0379363MP:0002499
MousePhenoshort vibrissae

CTSL CTSV

1.19e-0320362MP:0001282
MousePhenodecreased alpha-beta T cell number

CADM1 ZC3H12C CTSL CTSV STAT5B

1.20e-03315365MP:0012765
MousePhenosparse hair

CTSL CTSV STAT5B

1.21e-0382363MP:0000416
MousePhenoabnormal adipose tissue amount

RALGAPA1 EPRS1 IL31RA TM9SF1 DOCK7 SPG11 RAI1 STAT5B EPG5

1.30e-031077369MP:0005452
MousePhenounderdeveloped hair follicles

CTSL CTSV

1.31e-0321362MP:0000382
MousePhenothick dermal layer

CTSL CTSV

1.44e-0322362MP:0001245
MousePhenoabnormal heart left atrium morphology

CTSL CTSV

1.44e-0322362MP:0003923
MousePhenoenlarged sebaceous gland

CTSL CTSV

1.58e-0323362MP:0000652
MousePhenoaxon degeneration

PSAP SPG11 EPG5

1.63e-0391363MP:0005405
MousePhenoabnormal hippocampus layer morphology

PSAP SPG11 EPG5

1.68e-0392363MP:0000813
MousePhenoshiny skin

CTSL CTSV

1.72e-0324362MP:0001196
MousePhenoincreased central memory CD4-positive, alpha-beta T cell number

CTSL CTSV

1.72e-0324362MP:0010841
MousePhenoabnormal CD8-positive, alpha-beta T cell number

CADM1 ZC3H12C CTSL CTSV STAT5B

1.95e-03352365MP:0008077
MousePhenoadipose tissue phenotype

RALGAPA1 EPRS1 IL31RA TM9SF1 DOCK7 SPG11 STRA6 RAI1 STAT5B EPG5

2.00e-0313833610MP:0005375
MousePhenoinsulitis

CTSL CTSV

2.02e-0326362MP:0004031
MousePhenocardiac valve regurgitation

CTSL CTSV

2.02e-0326362MP:0009384
MousePhenoincreased keratinocyte proliferation

CTSL CTSV

2.17e-0327362MP:0009583
MousePhenoabnormal metabolism

EPRS1 SMTNL1 PSAP ABRAXAS1 TENT5A SPG11 STRA6 EPG5

2.20e-03936368MP:0005266
MousePhenoastrocytosis

PSAP SPG11 EPG5

2.32e-03103363MP:0003354
MousePhenoabnormal tail movements

CADM1 PSAP

2.51e-0329362MP:0001391
MousePhenoabnormal autophagy

PSAP SPG11 EPG5

2.52e-03106363MP:0008260
MousePhenoincreased astrocyte number

PSAP SPG11 EPG5

2.59e-03107363MP:0012065
MousePhenoabnormal central memory CD4-positive, alpha-beta T cell number

CTSL CTSV

2.68e-0330362MP:0012771
MousePhenoabnormal central memory CD4-positive, alpha-beta T cell morphology

CTSL CTSV

2.68e-0330362MP:0010840
MousePhenoabnormal heart valve physiology

CTSL CTSV

2.68e-0330362MP:0011926
MousePhenoabnormal CD8-positive, alpha beta T cell morphology

CADM1 ZC3H12C CTSL CTSV STAT5B

2.69e-03379365MP:0005010
DomainLatrophilin

ADGRL1 ADGRL2 ADGRL3

1.92e-083513PF02354
DomainGPCR_2_latrophilin_rcpt_C

ADGRL1 ADGRL2 ADGRL3

1.92e-083513IPR003334
DomainLectin_gal-bd_dom

ADGRL1 ADGRL2 ADGRL3

1.91e-075513IPR000922
DomainGal_Lectin

ADGRL1 ADGRL2 ADGRL3

1.91e-075513PF02140
DomainSUEL_LECTIN

ADGRL1 ADGRL2 ADGRL3

1.91e-075513PS50228
DomainGPCR_2_latrophilin

ADGRL1 ADGRL2 ADGRL3

1.91e-075513IPR003924
DomainGAIN_dom_N

ADGRL1 ADGRL2 ADGRL3

3.12e-0611513IPR032471
DomainGAIN

ADGRL1 ADGRL2 ADGRL3

3.12e-0611513PF16489
DomainOlfac-like_dom

ADGRL1 ADGRL2 ADGRL3

5.38e-0613513IPR003112
DomainOLF

ADGRL1 ADGRL2 ADGRL3

5.38e-0613513SM00284
DomainOLF

ADGRL1 ADGRL2 ADGRL3

5.38e-0613513PF02191
DomainOLF

ADGRL1 ADGRL2 ADGRL3

5.38e-0613513PS51132
DomainHormR

ADGRL1 ADGRL2 ADGRL3

4.23e-0525513SM00008
DomainHRM

ADGRL1 ADGRL2 ADGRL3

5.99e-0528513PF02793
DomainGPS

ADGRL1 ADGRL2 ADGRL3

1.08e-0434513SM00303
DomainGPCR_2_secretin-like_CS

ADGRL1 ADGRL2 ADGRL3

1.08e-0434513IPR017983
DomainGPS

ADGRL1 ADGRL2 ADGRL3

1.18e-0435513PF01825
DomainGPS

ADGRL1 ADGRL2 ADGRL3

1.29e-0436513PS50221
DomainGPS

ADGRL1 ADGRL2 ADGRL3

1.40e-0437513IPR000203
DomainInhibitor_I29

CTSL CTSV

1.52e-047512PF08246
DomainProt_inhib_I29

CTSL CTSV

1.52e-047512IPR013201
DomainInhibitor_I29

CTSL CTSV

1.52e-047512SM00848
DomainG_PROTEIN_RECEP_F2_1

ADGRL1 ADGRL2 ADGRL3

1.76e-0440513PS00649
DomainG_PROTEIN_RECEP_F2_3

ADGRL1 ADGRL2 ADGRL3

1.76e-0440513PS50227
DomainGPCR_2_extracellular_dom

ADGRL1 ADGRL2 ADGRL3

1.76e-0440513IPR001879
DomainPept_asp_AS

CTSL CTSV

3.24e-0410512IPR025661
DomainG_PROTEIN_RECEP_F2_2

ADGRL1 ADGRL2 ADGRL3

3.43e-0450513PS00650
Domain7tm_2

ADGRL1 ADGRL2 ADGRL3

3.43e-0450513PF00002
DomainPept_his_AS

CTSL CTSV

3.96e-0411512IPR025660
DomainPept_C1

CTSL CTSV

5.59e-0413512SM00645
DomainPeptidase_C1A_C

CTSL CTSV

5.59e-0413512IPR000668
DomainPeptidase_C1

CTSL CTSV

5.59e-0413512PF00112
DomainPeptidase_C1A

CTSL CTSV

5.59e-0413512IPR013128
DomainGPCR_2-like

ADGRL1 ADGRL2 ADGRL3

5.88e-0460513IPR017981
DomainGPCR_2_secretin-like

ADGRL1 ADGRL2 ADGRL3

5.88e-0460513IPR000832
DomainG_PROTEIN_RECEP_F2_4

ADGRL1 ADGRL2 ADGRL3

6.17e-0461513PS50261
DomainTHIOL_PROTEASE_CYS

CTSL CTSV

2.28e-0326512PS00139
DomainTHIOL_PROTEASE_ASN

CTSL CTSV

2.46e-0327512PS00640
DomainTHIOL_PROTEASE_HIS

CTSL CTSV

2.46e-0327512PS00639
DomainPept_cys_AS

CTSL CTSV

2.64e-0328512IPR000169
DomainCUB

NETO2 C1S

7.92e-0349512PF00431
PathwayWP_GPCRS_CLASS_B_SECRETINLIKE

ADGRL1 ADGRL2 ADGRL3

2.98e-0524363M39643
PathwayWP_GPCRS_CLASS_B_SECRETINLIKE

ADGRL1 ADGRL2 ADGRL3

2.98e-0524363MM15992
PathwayREACTOME_ACTIVATION_OF_MATRIX_METALLOPROTEINASES

SPOCK3 CTSL CTSV

1.21e-0438363MM14611
PathwayREACTOME_RUNX1_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_DIFFERENTIATION_OF_KERATINOCYTES

CTSL CTSV

1.76e-048362M27796
PathwayREACTOME_ENDOSOMAL_VACUOLAR_PATHWAY

CTSL CTSV

3.44e-0411362M525
PathwayREACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR

CTSL CTSV

4.86e-0413362M593
PathwayREACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR

CTSL CTSV

4.86e-0413362MM14659
PathwayWP_ENDOCHONDRAL_OSSIFICATION

CTSL CTSV STAT5B

6.27e-0466363MM15875
PathwayWP_PRIMARY_FOCAL_SEGMENTAL_GLOMERULOSCLEROSIS_FSGS

DKK1 CTSL CTSV

8.41e-0473363MM15906
Pubmed

A family of heptahelical receptors with adhesion-like domains: a marriage between two super families.

ADGRL1 ADGRL2 ADGRL3

3.15e-09352310994649
Pubmed

The multiple actions of black widow spider toxins and their selective use in neurosecretion studies.

ADGRL1 ADGRL2 ADGRL3

3.15e-09352315066411
Pubmed

Involvement of secretory and endosomal compartments in presentation of an exogenous self-glycolipid to type II NKT cells.

PSAP CTSL CTSV

3.15e-09352318292516
Pubmed

alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins.

ADGRL1 ADGRL2 ADGRL3

3.15e-09352311520923
Pubmed

The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins.

ADGRL1 ADGRL2 ADGRL3

6.28e-08652310964907
Pubmed

Lysosomal processing of progranulin.

PSAP CTSL CTSV

1.76e-07852328835281
Pubmed

Cartography of teneurin and latrophilin expression reveals spatiotemporal axis heterogeneity in the mouse hippocampus during development.

ADGRL1 ADGRL2 ADGRL3

3.75e-071052338713721
Pubmed

Identification of a membrane-associated cysteine protease with possible dual roles in the endoplasmic reticulum and protein storage vacuole.

CTSL CTSV

2.19e-06252211022031
Pubmed

B-cell lymphopoiesis is regulated by cathepsin L.

CTSL CTSV

2.19e-06252223585893
Pubmed

Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus.

CTSL CTSV

2.19e-0625229545226
Pubmed

Cathepsin L gene expression and promoter activation in rodent granulosa cells.

CTSL CTSV

2.19e-06252214563703
Pubmed

Cathepsin L is crucial for the development of early experimental diabetic nephropathy.

CTSL CTSV

2.19e-06252227575559
Pubmed

Acquisition of T regulatory function in cathepsin L-inhibited T cells by eye-derived CTLA-2alpha during inflammatory conditions.

CTSL CTSV

2.19e-06252219801522
Pubmed

Dilated cardiomyopathy in mice deficient for the lysosomal cysteine peptidase cathepsin L.

CTSL CTSV

2.19e-06252211972068
Pubmed

Identification of procathepsin L (pCTS-L)-neutralizing monoclonal antibodies to treat potentially lethal sepsis.

CTSL CTSV

2.19e-06252236735789
Pubmed

Cathepsin L plays an active role in involution of the mouse mammary gland.

CTSL CTSV

2.19e-06252212815617
Pubmed

Cathepsin L promotes Vascular Intimal Hyperplasia after Arterial Injury.

CTSL CTSV

2.19e-06252228332696
Pubmed

Cathepsin L inhibition prevents murine autoimmune diabetes via suppression of CD8(+) T cell activity.

CTSL CTSV

2.19e-06252220877570
Pubmed

Cathepsin L inactivates human trypsinogen, whereas cathepsin L-deletion reduces the severity of pancreatitis in mice.

CTSL CTSV

2.19e-06252219900452
Pubmed

Impaired turnover of autophagolysosomes in cathepsin L deficiency.

CTSL CTSV

2.19e-06252220536383
Pubmed

Response to comment on "Cathepsin-L influences the expression of extracellular matrix in lymphoid organs and plays a role in the regulation of thymic output and of peripheral T cell number".

CTSL CTSV

2.19e-06252216621972
Pubmed

Latrophilin receptors: novel bronchodilator targets in asthma.

ADGRL1 ADGRL3

2.19e-06252227325752
Pubmed

Stress-resistant Translation of Cathepsin L mRNA in Breast Cancer Progression.

CTSL CTSV

2.19e-06252225957406
Pubmed

Cathepsin L regulates pathogenicCD4 T cells in experimental autoimmune encephalomyelitis.

CTSL CTSV

2.19e-06252233540247
Pubmed

The protease cathepsin L regulates Th17 cell differentiation.

CTSL CTSV

2.19e-06252226343333
Pubmed

Lysosomal, cytoskeletal, and metabolic alterations in cardiomyopathy of cathepsin L knockout mice.

CTSL CTSV

2.19e-06252216636100
Pubmed

Cloning, genomic organization, and chromosomal localization of human cathepsin L.

CTSL CTSV

2.19e-0625228419312
Pubmed

Cathepsin L Regulates Metabolic Networks Controlling Rapid Cell Growth and Proliferation.

CTSL CTSV

2.19e-06252231010818
Pubmed

Increased nucleolar localization of SpiA3G in classically but not alternatively activated macrophages.

CTSL CTSV

2.19e-06252220338168
Pubmed

Thymocyte expression of cathepsin L is essential for NKT cell development.

CTSL CTSV

2.19e-06252212368909
Pubmed

Cloning and characterization of a mouse cysteine proteinase.

CTSL CTSV

2.19e-0625223533924
Pubmed

Surface activation of pro-cathepsin L.

CTSL CTSV

2.19e-0625221482371
Pubmed

Impaired hair follicle morphogenesis and cycling with abnormal epidermal differentiation in nackt mice, a cathepsin L-deficient mutation.

CTSL CTSV

2.19e-06252212163394
Pubmed

Expression of human cathepsin L or human cathepsin V in mouse thymus mediates positive selection of T helper cells in cathepsin L knock-out mice.

CTSL CTSV

2.19e-06252220347002
Pubmed

Cathepsin L coexists with Cytotoxic T-lymphocyte Antigen-2 alpha in distinct regions of the mouse brain.

CTSL CTSV

2.19e-06252227586811
Pubmed

Cathepsin L-deficient mice exhibit abnormal skin and bone development and show increased resistance to osteoporosis following ovariectomy.

CTSL CTSV

2.19e-06252215154914
Pubmed

Cathepsin-L ameliorates cardiac hypertrophy through activation of the autophagy-lysosomal dependent protein processing pathways.

CTSL CTSV

2.19e-06252223608608
Pubmed

Autophagy and cathepsin L are involved in the antinociceptive effect of DMBC in a mouse acetic acid-writhing model.

CTSL CTSV

2.19e-06252223912553
Pubmed

Developmental expression of cathepsin L and c-rasHa in the mouse placenta.

CTSL CTSV

2.19e-0625221751032
Pubmed

Inhibition of cathepsin L alleviates the microglia-mediated neuroinflammatory responses through caspase-8 and NF-κB pathways.

CTSL CTSV

2.19e-06252229154036
Pubmed

Peripheral cathepsin L inhibition induces fat loss in C. elegans and mice through promoting central serotonin synthesis.

CTSL CTSV

2.19e-06252231771567
Pubmed

Cathepsin L Helps to Defend Mice from Infection with Influenza A.

CTSL CTSV

2.19e-06252227716790
Pubmed

The radiation-induced nackt (nkt) allele is a loss-of-function mutation of the mouse cathepsin L gene.

CTSL CTSV

2.19e-06252216393949
Pubmed

Cathepsin L in bone marrow-derived cells is required for retinal and choroidal neovascularization.

CTSL CTSV

2.19e-06252220304958
Pubmed

Characterization and comparative mapping of the porcine CTSL gene indicates a novel synteny between HSA9q21-->q22 and SSC10q11-->q12.

CTSL CTSV

2.19e-06252211978977
Pubmed

Comparison of cathepsin L synthesized by normal and transformed cells at the gene, message, protein, and oligosaccharide levels.

CTSL CTSV

2.19e-0625222275556
Pubmed

Evolution of placentally expressed cathepsins.

CTSL CTSV

2.19e-06252212054558
Pubmed

The CD4 T cell-deficient mouse mutation nackt (nkt) involves a deletion in the cathepsin L (CtsI) gene.

CTSL CTSV

2.19e-06252211398968
Pubmed

Cathepsin L is involved in proliferation and invasion of breast cancer cells.

CTSL CTSV

2.19e-06252226639231
Pubmed

A variant of pulmonary alveolar microlithiasis in nackt mice.

CTSL CTSV

2.19e-06252212014504
Pubmed

An alternate targeting pathway for procathepsin L in mouse fibroblasts.

CTSL CTSV

2.19e-06252211929604
Pubmed

Deficiency for the cysteine protease cathepsin L promotes tumor progression in mouse epidermis.

CTSL CTSV

2.19e-06252220023699
Pubmed

Cathepsin L protects mice from mycoplasmal infection and is essential for airway lymphangiogenesis.

CTSL CTSV

2.19e-06252223600672
Pubmed

Mice that express enzymatically inactive cathepsin L exhibit abnormal spermatogenesis.

CTSL CTSV

2.19e-06252212533435
Pubmed

Impaired cathepsin L gene expression in skeletal muscle is associated with type 2 diabetes.

CTSL CTSV

2.19e-06252212941783
Pubmed

The lysosomal protease cathepsin L is an important regulator of keratinocyte and melanocyte differentiation during hair follicle morphogenesis and cycling.

CTSL CTSV

2.19e-06252212000732
Pubmed

Latrophilin GPCR signaling mediates synapse formation.

ADGRL2 ADGRL3

2.19e-06252233646123
Pubmed

Cathepsin L was involved in vascular aging by mediating phenotypic transformation of vascular cells.

CTSL CTSV

2.19e-06252236206719
Pubmed

Cathepsin-L influences the expression of extracellular matrix in lymphoid organs and plays a role in the regulation of thymic output and of peripheral T cell number.

CTSL CTSV

2.19e-06252215905545
Pubmed

Cathepsin-L, a key molecule in the pathogenesis of drug-induced and I-cell disease-mediated gingival overgrowth: a study with cathepsin-L-deficient mice.

CTSL CTSV

2.19e-06252212466121
Pubmed

Sequence and expression of the cDNA for MEP (major excreted protein), a transformation-regulated secreted cathepsin.

CTSL CTSV

2.19e-0625223689328
Pubmed

Mutant cells selected during persistent reovirus infection do not express mature cathepsin L and do not support reovirus disassembly.

CTSL CTSV

2.19e-06252210516062
Pubmed

Lysosomal cysteine peptidase cathepsin L protects against cardiac hypertrophy through blocking AKT/GSK3beta signaling.

CTSL CTSV

2.19e-06252219096818
Pubmed

Cathepsin L deficiency as molecular defect of furless: hyperproliferation of keratinocytes and pertubation of hair follicle cycling.

CTSL CTSV

2.19e-06252211023992
Pubmed

Proteolytic processing of dynamin by cytoplasmic cathepsin L is a mechanism for proteinuric kidney disease.

CTSL CTSV

2.19e-06252217671649
Pubmed

Close relationship of the major excreted protein of transformed murine fibroblasts to thiol-dependent cathepsins.

CTSL CTSV

2.19e-0625223755373
Pubmed

[Effect of bushen tiaojing recipe and xiaoyao pill on expression of cathepsin-L mRNA in gonadotropin-primed mice].

CTSL CTSV

2.19e-06252221434350
Pubmed

Alterations during positive selection in the thymus of nackt CD4-deficient mice.

CTSL CTSV

2.19e-06252211119260
Pubmed

Contribution of cathepsin L to secretome composition and cleavage pattern of mouse embryonic fibroblasts.

CTSL CTSV

2.19e-06252221972973
Pubmed

Cell type-specific functions of the lysosomal protease cathepsin L in the heart.

CTSL CTSV

2.19e-06252217942402
Pubmed

Cathepsin L stabilizes the histone modification landscape on the Y chromosome and pericentromeric heterochromatin.

CTSL CTSV

2.19e-06252216705169
Pubmed

Loss of responsiveness to IGF-I in cells with reduced cathepsin L expression levels.

CTSL CTSV

2.19e-06252218469859
Pubmed

Cortical Thymocytes Along With Their Selecting Ligands Are Required for the Further Thymic Maturation of NKT Cells in Mice.

CTSL CTSV

2.19e-06252232457751
Pubmed

The human cysteine protease cathepsin V can compensate for murine cathepsin L in mouse epidermis and hair follicles.

CTSL CTSV

2.19e-06252215679121
Pubmed

Complete nucleotide and deduced amino acid sequences of human and murine preprocathepsin L. An abundant transcript induced by transformation of fibroblasts.

CTSL CTSV

2.19e-0625222835398
Pubmed

Cloning and expression of the gene for the major excreted protein of transformed mouse fibroblasts. A secreted lysosomal protease regulated by transformation.

CTSL CTSV

2.19e-0625222826441
Pubmed

Inhibition of cysteine protease cathepsin L increases the level and activity of lysosomal glucocerebrosidase.

CTSL CTSV

2.19e-06252238329128
Pubmed

Identification on melanoma cells of p39, a cysteine proteinase that cleaves C3, the third component of complement: amino-acid-sequence identities with procathepsin L.

CTSL CTSV

2.19e-0625228554545
Pubmed

Cathepsin L plays a major role in cholecystokinin production in mouse brain cortex and in pituitary AtT-20 cells: protease gene knockout and inhibitor studies.

CTSL CTSV

2.19e-06252219589362
Pubmed

Cathepsin L is essential for onset of autoimmune diabetes in NOD mice.

CTSL CTSV

2.19e-06252216184198
Pubmed

The lysosomal cysteine protease cathepsin L regulates keratinocyte proliferation by control of growth factor recycling.

CTSL CTSV

2.19e-06252216079282
Pubmed

Cathepsin L activity is essential to elastase perfusion-induced abdominal aortic aneurysms in mice.

CTSL CTSV

2.19e-06252221868704
Pubmed

Cathepsin-L contributes to cardiac repair and remodelling post-infarction.

CTSL CTSV

2.19e-06252221147810
Pubmed

Cathepsin L proteolytically processes histone H3 during mouse embryonic stem cell differentiation.

CTSL CTSV

2.19e-06252218957203
Pubmed

Latrophilin GPCRs direct synapse specificity by coincident binding of FLRTs and teneurins.

ADGRL2 ADGRL3

2.19e-06252230792275
Pubmed

Nackt (nkt), a new hair loss mutation of the mouse with associated CD4 deficiency.

CTSL CTSV

6.57e-06352210199917
Pubmed

Cathepsin Protease Controls Copper and Cisplatin Accumulation via Cleavage of the Ctr1 Metal-binding Ectodomain.

CTSL CTSV

6.57e-06352227143361
Pubmed

Neuronal loss and brain atrophy in mice lacking cathepsins B and L.

CTSL CTSV

6.57e-06352212048238
Pubmed

Human and mouse perforin are processed in part through cleavage by the lysosomal cysteine proteinase cathepsin L.

CTSL CTSV

6.57e-06352220497254
Pubmed

Fitness of heterozygotes of deleterious recessive mutations in the mouse.

CTSL CTSV

6.57e-0635225563943
Pubmed

Inhibitory fragment from the p41 form of invariant chain can regulate activity of cysteine cathepsins in antigen presentation.

CTSL CTSV

6.57e-06352218362148
Pubmed

Up-regulation of cathepsin B and cathepsin L activities in scrapie-infected mouse Neuro2a cells.

CTSL CTSV

6.57e-06352212867662
Pubmed

The PI3K regulatory subunits p55α and p50α regulate cell death in vivo.

CTSL CTSV

6.57e-06352224902901
Pubmed

Deletion of cysteine cathepsins B or L yields differential impacts on murine skin proteome and degradome.

CTSL CTSV

6.57e-06352223233448
Pubmed

Cathepsin L activity controls adipogenesis and glucose tolerance.

CTSL CTSV

6.57e-06352217643114
Pubmed

Invariant chain controls the activity of extracellular cathepsin L.

CTSL CTSV

6.57e-06352212417635
Pubmed

Cathepsins D and L reduce the toxicity of advanced glycation end products.

CTSL CTSV

6.57e-06352222245096
Pubmed

Conditional Gene Targeting Reveals Cell Type-Specific Roles of the Lysosomal Protease Cathepsin L in Mammary Tumor Progression.

CTSL CTSV

6.57e-06352232707827
Pubmed

Secreted cathepsin L generates endostatin from collagen XVIII.

CTSL CTSV

6.57e-06352210716919
Pubmed

Double deficiency of cathepsins B and L results in massive secretome alterations and suggests a degradative cathepsin-MMP axis.

CTSL CTSV

6.57e-06352223811845
GeneFamilyAdhesion G protein-coupled receptors, subfamily L

ADGRL1 ADGRL2 ADGRL3

1.65e-084303918
GeneFamilyCathepsins

CTSL CTSV

2.76e-0415302470
GeneFamilyComplement system|Sushi domain containing

C1S CFHR3

1.62e-0336302492
GeneFamilyHyalectan proteoglycans|V-set domain containing|Sushi domain containing|C-type lectin domain containing

C1S CFHR3

4.01e-03573021179
ToppCellLPS-IL1RA-Endothelial-Endothelial-Alv_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SPOCK3 ZC3H12C ADGRL2 ITM2B ADGRL3

2.16e-06180525544fb373a3346186ec60afe2cfcf141bb04a1eed
ToppCellLPS-antiTNF-Endothelial-Endothelial-Alv_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SPOCK3 ZC3H12C ADGRL2 ITM2B ADGRL3

2.16e-0618052530cf3c7ee29694eaccb89bf8053a82037d5c9f1d
ToppCell5'-Adult-LymphNode-Mesenchymal-fibroblastic-Transitional_Stromal_3_(C3+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DKK1 PRICKLE2 C1S CTSL CFHR3

2.22e-06181525ab66a89f316b935d9ba1277426d976b1e9e39757
ToppCellControl-Endothelial-Endothelial-Activated_Alv_Cap|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SPOCK3 PRICKLE2 ZC3H12C ADGRL2 ADGRL3

2.35e-06183525e81c142770f44fd902b0631bc360c5b5339d4c75
ToppCellfacs-Bladder-nan-18m|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RND1 PSAP SPOCK3 STRA6 CTSL

2.47e-061855253e00879466e626aa8604efecfc4678d64f54dbfc
ToppCellfacs-Bladder-nan-18m-Epithelial|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RND1 PSAP SPOCK3 STRA6 CTSL

2.47e-061855253dc5812c961ff209f197ff4cbfb90009c0537550
ToppCellControl-Endothelial-Endothelial-Alv_Cap|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SPOCK3 PRICKLE2 ZC3H12C ADGRL2 ADGRL3

2.61e-06187525ea9d34bcd3bd1f36745846309ede349773de501a
ToppCellControl-Endothelial-VE_Capillary_A|Endothelial / Disease state, Lineage and Cell class

NETO2 PRICKLE2 ADGRL2 ITM2B ADGRL3

2.68e-0618852588b3415e33db81726dd29c1f50c886e057af50a0
ToppCellLPS_only-Endothelial-Endothelial-Alv_Cap|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SPOCK3 PRICKLE2 ZC3H12C ADGRL2 ADGRL3

2.82e-06190525474cbbab8f3b0a6881fa6c92edb78e43999f9ab0
ToppCellCOPD-Lymphoid-T_Regulatory|Lymphoid / Disease state, Lineage and Cell class

KAT2B CADM1 NETO2 ZC3H12C STAT5B

2.89e-061915253ae18bc4e3dff49b5d5958da8ebc3f747274b69c
ToppCellLPS_only-Endothelial-Endothelial-Activated_Alv_Cap|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

RND1 SPOCK3 ZC3H12C ADGRL2 ADGRL3

2.89e-06191525a7b18bcf27c38ad2353c239ecb309c80f3ef3359
ToppCellFetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D150|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NETO2 PRICKLE2 ADGRL2 ITM2B ADGRL3

2.97e-061925257197e401e563441ab94815f7619e032ebef9e586
ToppCelldistal-Endothelial-Capillary_Aerocyte-3|distal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NETO2 PRICKLE2 ADGRL2 ITM2B ADGRL3

3.62e-06200525d36236c7703b759309c8347f44900fc4bed377f0
ToppCell(6)_Endothelial_cells-(6)_Endothelial-C_(Capillary_Aerocyte_)|(6)_Endothelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

NETO2 PRICKLE2 ADGRL2 ITM2B

3.39e-0515752484f629b7f589ca8a1abc220fa740c4a6fdc1b579
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Neural-neural_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CADM1 ART3 TEKT5 ADGRL3

3.83e-05162524d28b2ea1d2c8f3c6a107991573471b6d0c49c4ae
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CADM1 ART3 TEKT5 ADGRL3

3.83e-05162524eed223e61c8162a2fe004ab4e09de5e037be7553
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Neural-neural_cell-Schwann_Cell_/_Neural-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CADM1 ART3 TEKT5 ADGRL3

3.83e-051625245bbd7130d4dad9035e73a439dda568195c136f31
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Neural|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

CADM1 ART3 TEKT5 ADGRL3

3.83e-05162524e35ddce830e20ebeac1a2c405293fc4a5323dd4a
ToppCellPND03-Endothelial-Endothelial_blood-vessel-Microvascular_EC-CAP2-CAP2_prolif|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ART3 ICE2 PRICKLE2 ADGRL2

4.42e-05168524c7021748003e5949f7caf7b3291c5bad294948c1
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PRICKLE2 C1S ADGRL2 ADGRL3

4.52e-05169524c0824a93674e2bff0f09b2d2fab5bab016a2e379
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast-Adaptive_/_Maladaptive_/_Repairing_Fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DKK1 PRICKLE2 C1S ADGRL3

5.41e-051775249ec7f1e64312d26d434b3312b58386715dbad644
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

DKK1 PRICKLE2 C1S ADGRL3

5.41e-05177524016277dfd59b1793fddaaadc2b3f41622d76ce3a
ToppCell5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PRICKLE2 C1S ADGRL2 ADGRL3

5.77e-05180524f2f6e83127a4a415e65c76a35efa8175fbd5b5d9
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DCDC1 ART3 ADGRL2 ATP4A

6.29e-0518452430fddbc9696476d4d7f08e53f84ea994a4ed873a
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L2-3_LINC00507_RPL9P17|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

DCDC1 ART3 ADGRL2 ATP4A

6.29e-0518452496926efa220f03d0787322c9519bb9e8f64f74d0
ToppCell(1)_Control_(PBS)-(2)_LEPR+_perivascular_cells_and_VE-Cad+_vascular_cells_(mixed)|World / Stress and Cell class

CADM1 PSAP ITM2B CTSL

6.42e-05185524b8cd94cf18308b514fc61557550225794ffd2860
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Activated_Alv_Cap|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SPOCK3 ZC3H12C ADGRL2 ADGRL3

6.69e-05187524f3397dbc23b6c2f24e2c1ba887d8f9aef3ee01a1
ToppCellAdult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)|Adult / Lineage, Cell type, age group and donor

NETO2 PRICKLE2 ADGRL2 ADGRL3

6.83e-05188524e5cad03f4a64147fe8174e7f614cf45233ffb9b7
ToppCellLPS-IL1RA+antiTNF-Endothelial-Endothelial-Alv_Cap|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SPOCK3 ZC3H12C ADGRL2 ADGRL3

6.83e-0518852473f6ec915934154f435a376cb274b058ff7c5f35
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PRICKLE2 C1S ADGRL3 CFHR3

6.83e-05188524997dcfc4f08738ab398d8abc15e4fd2fc6619862
ToppCellLAM-Endothelial-VasEndo-1|Endothelial / Condition, Lineage and Cell class

NETO2 PRICKLE2 ADGRL2 ITM2B

6.83e-05188524f24c33d960ca93459584a79ff8f0ec20db6a34d5
ToppCellControl-Endothelial-Endothelial-Alv_Gen_Intermediate|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SPOCK3 PRICKLE2 ZC3H12C ADGRL3

6.98e-051895245d7ae1ead7f4fbaeec26f651833c9c2106e1e4d1
ToppCellChildren_(3_yrs)-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D139|Children_(3_yrs) / Lineage, Cell type, age group and donor

NETO2 PRICKLE2 ADGRL2 ADGRL3

7.12e-051905240a351609a72fd638c84b2435782e312ee6a33aac
ToppCellFetal_29-31_weeks-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

NETO2 PRICKLE2 ADGRL2 ADGRL3

7.27e-051915241de0bdfd13bd930691564c2673f2e66393bc0255
ToppCellLPS-antiTNF-Endothelial-Endothelial-Activated_Alv_Cap|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SPOCK3 ZC3H12C ADGRL2 ADGRL3

7.41e-05192524c618ede75dce3988c87a5b8f98d8e94e1dd66efd
ToppCellLPS-IL1RA-Endothelial-Endothelial-Activated_Alv_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SPOCK3 ZC3H12C ADGRL2 ADGRL3

7.56e-05193524a3636c35ed25aabe2f1aba016c9fe125327bbfaf
ToppCellControl-Endothelial-Endothelial|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PRICKLE2 ZC3H12C ADGRL2 ADGRL3

7.56e-05193524aff0649c73c634bc6ff0dc7759b4693a9236bf05
ToppCellControl-Endothelial|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

PRICKLE2 ZC3H12C ADGRL2 ADGRL3

7.56e-05193524c5f9fe03e64c211d4bcd4959e5b32f14841e336a
ToppCellIPF-Endothelial-VE_Capillary_A|Endothelial / Disease state, Lineage and Cell class

NETO2 PRICKLE2 ADGRL2 ITM2B

7.72e-05194524777ce41c3f22c591e2d81120f189b834e53ffb4b
ToppCellNeuron-Postmitotic-Inhibitory_Neuron-MGE2|World / Primary Cells by Cluster

CADM1 NETO2 SPOCK3 TENT5A

7.72e-05194524b42fd64b0fb95434a9e4e6586f31d26114a4074b
ToppCellNeuron-Postmitotic-Inhibitory_Neuron-MGE2-10|World / Primary Cells by Cluster

CADM1 NETO2 SPOCK3 TENT5A

7.72e-0519452481e7bc6516ab8d02ccd1c76a56a3533b788c27c8
ToppCellLPS-IL1RA-Endothelial-Endothelial|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SPOCK3 ZC3H12C ADGRL2 ADGRL3

7.72e-051945241d39d968730a7e85b6161c1c8a6bd38afe9bcad7
ToppCellLPS-IL1RA-Endothelial|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

SPOCK3 ZC3H12C ADGRL2 ADGRL3

7.72e-0519452443f92b0533e26633dc94cce554045d641ef8fd76
ToppCellPND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_mature|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CADM1 ART3 C1S ADGRL3

7.87e-051955247a32a8535c29b819dacba901d0658280a2631c94
ToppCell3'-Parenchyma_lung-Endothelial-Blood_vessel_EC-capillary_endothelial_cell-EC_aerocyte_capillary-EC_aerocyte_capillary_L.2.0.1.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

PRICKLE2 ADGRL2 ITM2B ADGRL3

7.87e-05195524e8992c549dad9a88d2b8d01039a8d02a950b29b4
ToppCellPND01-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte|PND01 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CADM1 ART3 C1S ADGRL3

7.87e-051955244a5d2f62aad5817d077177bf8b4ff0e46d3b8d97
ToppCell5'-Adult-LargeIntestine-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PRICKLE2 C1S ADGRL2 ADGRL3

8.03e-051965242ab9735aa7a7e95dcf6b0bdf0427f7b57f6349ee
ToppCellproximal-Endothelial-Capillary-3|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NETO2 ADGRL2 CTSV ADGRL3

8.19e-05197524ddb8ea895f0f34d4f20a0740b708fa0f3e378801
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CADM1 C1S ITM2B ADGRL3

8.19e-051975242e3d64648a1e4f01b9256a96b94b8a640ee1824c
ToppCellproximal-Endothelial-Capillary|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NETO2 ADGRL2 CTSV ADGRL3

8.19e-0519752453baef54bd85c60ae24a3c163b3a3d937fb6ff0b
ToppCellproximal-3-Endothelial-Capillary|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NETO2 ADGRL2 CTSV ADGRL3

8.19e-05197524a1a61c03d67272693ec23e0d15f0a12bf618e2da
ToppCell3'-GW_trimst-2-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CADM1 C1S ITM2B ADGRL3

8.19e-05197524d9e196c8b4a6ede4733946dbdba3331534954beb
ToppCell5'-Adult-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(CCL11+)|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

PRICKLE2 C1S ADGRL2 ADGRL3

8.35e-051985247582ee9ec8a87ecb094201f1f9191b412f9d2875
ToppCell3'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_2_(NPY+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CADM1 C1S ITM2B ADGRL3

8.51e-0519952405777e92344aedabfb5a72207c6632dc64205534
ToppCell5'-GW_trimst-1.5-SmallIntestine-Mesenchymal-fibroblastic-Stromal_1_(ADAMDEC1+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CADM1 C1S CTSL ADGRL3

8.51e-05199524bdedcc7c8f3be0996200c882dda82fb2658655c0
ToppCellILEUM-non-inflamed-(8)_Fibroblast-(8)_Fibroblasts|(8)_Fibroblast / shred on tissue, inflammation_status, cell class(v3), cell subclass (v2)

CADM1 C1S ADGRL2 ADGRL3

8.51e-0519952456d72da6a5fab9cbb2975fe6f87a631debaba6a8
ToppCelldistal-3-Endothelial-Capillary_Aerocyte|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)

NETO2 PRICKLE2 ADGRL2 ITM2B

8.68e-05200524e12598a097dd9c4cbf9bb85bfa3057722ef73ad5
ToppCell10x_5'_v1-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I-Z|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CADM1 PSAP ITM2B CTSL

8.68e-05200524a2548b0c77ba1616638351b111cce2fe0cacaa95
ToppCell10x_5'_v1-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I|10x_5'_v1 / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group

CADM1 PSAP ITM2B CTSL

8.68e-05200524e4a499b69554f78161c2c47199da77c201910e73
ToppCellLPS_IL1RA_TNF-Endothelial-Endothelial-Alv_Gen_Intermediate|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type

SPOCK3 ADGRL2 ITM2B ADGRL3

8.68e-0520052458a7ece7dfdf6c46f2a50cbcb580574dec14c748
ToppCellLPS_only-Endothelial-Endothelial-Alv_Cap|LPS_only / Treatment groups by lineage, cell group, cell type

SPOCK3 ZC3H12C ADGRL2 ITM2B

8.68e-05200524432384faeade8e609154fab3d96c955a8ec868dd
ToppCellBronchial-NucSeq-Endothelial-Endothelia_vascular-VE_alveolar_capillary_Car4_aerocyte|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

NETO2 PRICKLE2 ADGRL2 ADGRL3

8.68e-05200524105c67e4f5eff036013d655c8e8ac577d32dae2e
ToppCellLPS_IL1RA-Endothelial-Endothelial-Activated_Alv_Cap|LPS_IL1RA / Treatment groups by lineage, cell group, cell type

SPOCK3 ZC3H12C ADGRL2 ITM2B

8.68e-0520052479e51afb57ca38aacebd0298e5e727b55c0cfff9
ToppCellLA-04._Ventricular_Cardiomyocyte_I|LA / Chamber and Cluster_Paper

KAT2B B3GNT3 ADGRL2

2.88e-0411052334dcd1e1e16e8b6088ff9a7a40532e8bd000c121
ToppCellfrontal_cortex-Neuronal-glutamatergic_neuron-L6_CT-L6_CT_ALM_Nxph2_Sla|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

ART3 TEKT5 NXPH2

5.13e-041345236d97fa07f55ae20c17b9d5262e893957cccc6dba
ToppCellPND01-03-samps-Mesenchymal-Pericyte-pericyte_E|PND01-03-samps / Age Group, Lineage, Cell class and subclass

ART3 C1S PP2D1

5.24e-0413552335928195cf34f055b353562c96f451aef2344d64
ToppCellCOVID-19_Severe-Classical_Monocyte-|Classical_Monocyte / Disease condition and Cell class

PRICKLE2 C1S ADGRL3

5.36e-04136523e272d11bb52f890f6681cc9384aeac27976ec650
ToppCellPBMC-Severe-Myeloid-Classical_Monocyte-Classical_Monocyte-|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

PRICKLE2 C1S ADGRL3

5.47e-0413752312caa8ed7cc9e7a0f78c14ad5efe2fc28c3ce9be
ToppCell343B-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)-|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

NETO2 PRICKLE2 ADGRL2

5.71e-041395232fdc8f36510aff24abbc79ef2a842db75a85f946
ToppCell343B-Endothelial_cells-Endothelial-C_(Capillary_Aerocyte_)|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)

NETO2 PRICKLE2 ADGRL2

5.71e-041395235970a654c64e3b54f9d18c102f5b125eec892fc5
ToppCellCOVID-19_Severe-Classical_Monocyte-|COVID-19_Severe / Disease condition and Cell class

PRICKLE2 C1S ADGRL3

5.83e-04140523cade44740dd3acca7789591aa5a7935d48d5cbee
ToppCell10x_3'_v3-lymph_node_(10x_3'_v3)-hematologic-hematopoietic_progenitor-hematopoietic_stem_cell|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SMTNL1 STRA6 ATP4A

6.20e-0414352327e06327f96cb72bd111ea6ece6307e5ebb3a146
ToppCell10x_3'_v3-lymph_node_(10x_3'_v3)-hematologic-hematopoietic_progenitor|lymph_node_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type

SMTNL1 STRA6 ATP4A

6.20e-041435234edef95ae2a1ef4fc4b0d4fadf75bfc54b583932
ToppCellFrontal_cortex-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)|Frontal_cortex / BrainAtlas - Mouse McCarroll V32

NETO2 SPOCK3 NXPH2

6.45e-041455238b13b576fd2e6e33ccb146860a91a53cee0cdd4d
ToppCell368C-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)-|368C / Donor, Lineage, Cell class and subclass (all cells)

DKK1 ART3 C1S

7.40e-041525233a1414ba6a4972698c3262a00b124428835c35cb
ToppCell368C-Fibroblasts-Fibroblast-A_(Fibroblast_progenitors)|368C / Donor, Lineage, Cell class and subclass (all cells)

DKK1 ART3 C1S

7.40e-04152523ee7855d76a49d07a032677a4dc83aa6116d50518
ToppCellprimary_visual_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Plch2_Dock5|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SPOCK3 TENT5A ITM2B

7.40e-04152523fed80b467ec9e30c7f98bed6cc4f8c583b715e9e
ToppCellPBMC-Mild-Myeloid-cDC-cDC-cDC_3|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

TEKT5 CTSV ADGRL3

7.83e-041555239a27558c457f05808af07190b7a5006b047f1d58
ToppCellPBMC-Mild-Myeloid-cDC-cDC-cDC_3|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

TEKT5 CTSV ADGRL3

7.83e-04155523ab539c04f10276ae919d82b1c75f99a84eb695bf
ToppCelldroplet-Kidney-KIDNEY-30m-Myeloid-nan|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

IL31RA CADM1 TENT5A

7.98e-041565236e60e860603a7e8194f437a574ff8e887f6083b8
ToppCellfrontal_cortex-Neuronal-GABAergic_neuron-Lamp5-Lamp5_Plch2_Dock5|frontal_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype

SPOCK3 TENT5A ITM2B

8.13e-04157523516903469756c5fabfdf56d7bd59b3bdd7b44e39
ToppCellAT1-AT2_cells-Myositis-ILD_01|World / lung cells shred on cell class, cell subclass, sample id

DKK1 C1S B3GNT3

8.28e-041585233bc51cfd37b289cc3e866b54ce55a298e5eff690
ToppCellTCGA-Kidney-Solid_Tissue_Normal-Kidney-Kidney_normal_tissue-5|TCGA-Kidney / Sample_Type by Project: Shred V9

STRA6 CTSV NXPH2

8.28e-0415852334b284a62cc3fb90429ce579fd8cb8a60178091b
ToppCell367C-Lymphocytic-CD8+_Cytotoxic_T-cell-CD8+_Cytotoxic_T_cell_3|Lymphocytic / Donor, Lineage, Cell class and subclass (all cells)

TENT5A PFKFB2 CATSPERG

8.58e-04160523955acb023ce4ccfac5073c9d693db87db3856187
ToppCellBAL-Mild-Myeloid-MoAM-MoAM5-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RND1 DKK1 ADGRL2

9.55e-04166523006ced12f69ef13ddcba5a3891ddc7c18c384863
ToppCellBAL-Mild-Myeloid-MoAM-MoAM5|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

RND1 DKK1 ADGRL2

9.55e-04166523ac28c8cac1e94be0c47fb862c5809c92cdaa11f3
ToppCellBAL-Mild-Myeloid-MoAM-MoAM5-|Mild / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

RND1 DKK1 ADGRL2

9.55e-041665236bb3410e65c971acc458c472015afcec6de6e310
ToppCellBAL-Mild-Myeloid-MoAM-MoAM5|Mild / Location, Disease Group, Cell group, Cell class (2021.03.09)

RND1 DKK1 ADGRL2

9.55e-04166523823ec03714884cb860a1260410feac8c536b6d06
ToppCelldroplet-Heart-nan-24m-Mesenchymal-coronary_vascular_endothelial_cell|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ART3 PRICKLE2 B3GNT3

9.71e-04167523a35ace2c722936d2a3e1f0826e5b6ec6b1340d2b
ToppCelldroplet-Trachea-3m-Mesenchymal-fibroblast-fibroblast_of_trachea-|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RND1 ART3 B3GNT3

9.71e-04167523774f3264318b002d0df5d06d41d645366038d0bf
ToppCellAdult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D231|Adult / Lineage, Cell type, age group and donor

PRICKLE2 ADGRL2 ADGRL3

9.71e-041675235af9127bae05768a5164d5708a4ad37edca99324
ToppCellCOVID-19-Heart-Neuronal|COVID-19 / Disease (COVID-19 only), tissue and cell type

CADM1 ART3 ADGRL3

9.88e-0416852388c2c574f428c2502b5fe099bd73b0758f668ef6
ToppCelltumor_Lymph_Node_/_Brain-Fibroblasts-COL13A1+_matrix_FBs|Fibroblasts / Location, Cell class and cell subclass

RND1 ABRAXAS1 C1S

1.01e-0316952384b898a9fd8ced67c6a501d5cef6416f519902c4
ToppCellfacs-Marrow-T_cells-18m-Hematologic-MPP_Fraction_B_+_C|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ZMYND19 ABRAXAS1 ATP4A

1.01e-031695232a35846b0e0be0a19a5a04a86cbd72ce65257c8a
ToppCellAdult-Endothelial-alveolar_capillary_endothelial_cell_(Cap2;_aerocyte)-D122|Adult / Lineage, Cell type, age group and donor

NETO2 PRICKLE2 ADGRL2

1.04e-03171523bd20e85d36fa9d7ddc8afef6a1dea75efc9ee1dc
ToppCelldroplet-Lung-nan-21m-Myeloid-dendritic_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CADM1 ZC3H12C CATSPERG

1.04e-03171523159ce6d5513008532dd7785b915b3fe7440cc4b2
ToppCelldroplet-Kidney-nan-3m-Epithelial-Pecam____kidney_capillary_endothelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

ART3 PRICKLE2 ADGRL3

1.06e-03172523073a503dc922e3e3ac3528e249b0f8b74402110b
ToppCellAdult-Mesenchymal-vascular_smooth_muscle_cell|Adult / Lineage, Cell type, age group and donor

DKK1 ART3 ADGRL3

1.06e-03172523c62cad0f4212d1e9ea1ec3143ad3c4e06aff0ebf
ToppCellPND07-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-Pericyte-Pericyte_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CADM1 ART3 C1S

1.06e-0317252303a0aff6b7971093a4347b5ed12546d78374c56f
ToppCell3'-GW_trimst-1.5-LargeIntestine-Neuronal-Glial_immature-Glia_1_(DHH+)|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

CADM1 DCDC1 ZC3H12C

1.08e-03173523922356a5b4c84607318ac24d7caa2e235b72b066
ComputationalGenes upregulated in subsets of cells of a given type within various tumors

EPRS1 PSAP ITM2B CTSL

9.03e-0650294GAVISH_3CA_MALIGNANT_METAPROGRAM_10_PROTEIN_MATURATION
Diseaseattention deficit hyperactivity disorder (implicated_via_orthology)

ADGRL1 ADGRL2 ADGRL3

1.55e-0528513DOID:1094 (implicated_via_orthology)
Diseaseotitis media (biomarker_via_orthology)

CTSL CTSV

3.92e-0417512DOID:10754 (biomarker_via_orthology)
Diseaseoptic disc size measurement

KAT2B DCDC1 PCNX4 STRA6

4.38e-04205514EFO_0004832
Diseasenephrotic syndrome (biomarker_via_orthology)

CTSL CTSV

7.89e-0424512DOID:1184 (biomarker_via_orthology)
Diseasecolorectal adenocarcinoma (is_marker_for)

STRA6 STAT5B

1.00e-0327512DOID:0050861 (is_marker_for)
Diseasehyperthyroidism (biomarker_via_orthology)

CTSL CTSV

1.08e-0328512DOID:7998 (biomarker_via_orthology)
Diseasemuscular atrophy (biomarker_via_orthology)

CTSL CTSV

1.15e-0329512DOID:767 (biomarker_via_orthology)
DiseaseComplement deficiency disease

C1S CFHR3

1.49e-0333512C0272242

Protein segments in the cluster

PeptideGeneStartEntry
VYTIDIQKYIPCYQL

ABRAXAS1

56

Q6UWZ7
PYYLKINYSCEEKPS

CATSPERG

96

Q6ZRH7
CYKVTYRPLDPDNYD

PFKFB2

196

O60825
PLFYPCQYYLLKNEQ

EPG5

1066

Q9HCE0
RPLYQYVNYCNPELN

C16orf86

191

Q6ZW13
SYPYVAVDEICKYRP

CTSV

201

O60911
PGTYKYLEVQYDCVP

ADGRL1

116

O94910
YLEVQYDCVPYKVEQ

ADGRL1

121

O94910
PGTYKYLEVQYECVP

ADGRL3

111

Q9HAR2
YLEVQYECVPYKVEQ

ADGRL3

116

Q9HAR2
EQYEEQGPYIVYRKC

ACTL9

401

Q8TC94
KYLEVQYECVPYIFV

ADGRL2

121

O95490
QKVCPDYNYHSETPY

NXPH2

246

O95156
YCQPDAAVRTPEQYY

RAI1

321

Q7Z5J4
VCGYPVIVQKYKPYN

DCDC1

1241

M0R2J8
YVVYRQVCNSDPPCY

MAGEB6

341

Q8N7X4
LQPDDVYYCGIKYIK

ITM2B

81

Q9Y287
FTNCKEYNPPESEYY

KAT2B

796

Q92831
EYNPPESEYYKCANI

KAT2B

801

Q92831
LPAKPENISCVYYYR

IL31RA

21

Q8NI17
KLGYCAPPYIYVNQI

PCNX4

31

Q63HM2
YVPQEEVPVYENKYV

PYM1

36

Q9BRP8
QYYSCLPEEKVPYVN

PRICKLE2

51

Q7Z3G6
RYFCQLYTDPPQESY

CADM1

121

Q9BY67
PQSRVEYQCQPYYEL

CFHR3

231

Q02985
QFPVYVLPKVEYQAC

ICE2

766

Q659A1
PNKAYIQITYVEPYF

DOCK7

1906

Q96N67
NYPKPYPENSRCEYQ

C1S

191

P09871
KYYVPEVVTQNERYP

B3GNT3

251

Q9Y2A9
GNKYQTIDNYQPYPC

DKK1

71

O94907
FCQLYLNEKDYPPGY

ATP4A

566

P20648
IYTYPCIPEYEEKDH

DTWD1

121

Q8N5C7
AYYYCNPPPAEKTVK

UPF2

751

Q9HAU5
YNVYPTYDFACPIVD

EPRS1

371

P07814
LLTTYKKDYNPYPVC

SAXO1

101

Q8IYX7
DCYPETYVPTVFENY

RND1

36

Q92730
AVQAPVIQECYQPYY

TEKT5

26

Q96M29
DEVYSKYYTPVPCES

STAT5B

676

P51692
NYPDSYPPNKECIYI

NETO2

61

Q8NC67
RAECPQVPKIYKYYS

STRA6

191

Q9BX79
SYPYEATEESCKYNP

CTSL

201

P07711
YVYLDCYKLSPENCP

SPG11

1006

Q96JI7
YYECHYPPCTVIEKQ

ZMYND19

166

Q96E35
LYNLVSVYPDKYCPL

ZER1

706

Q7Z7L7
KYYLPYIFPNICKEN

RALGAPA1

246

Q6GYQ0
VPDSKCVYTYIQELY

SMTNL1

466

A8MU46
PYQKQCDQFVAEYEP

PSAP

446

P07602
QYIPLCDEDGYYKPT

SPOCK3

336

Q9BQ16
VAPSRPFVVYCQYKE

TRMT6

391

Q9UJA5
QPEAPYYYVNIEKTE

XKR3

416

Q5GH77
EQYPKCDSPVDIGYY

ZC3H12C

576

Q9C0D7
VTCYYQPAPYVADAN

TENT5A

401

Q96IP4
QETYHYYQLPVCCPE

TM9SF1

56

O15321
KYCIYNPENVETFPA

PP2D1

541

A8MPX8
NCIENLEYFQPIYVY

ART3

266

Q13508