Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionhistone H3K4 monomethyltransferase activity

KMT2C KMT2D KMT2B

1.53e-088143GO:0140945
GeneOntologyMolecularFunctionhistone H3K4 trimethyltransferase activity

KMT2C KMT2D KMT2B

3.28e-0810143GO:0140999
GeneOntologyMolecularFunctionhistone H3K4 methyltransferase activity

KMT2C KMT2D KMT2B

3.11e-0720143GO:0042800
GeneOntologyMolecularFunctionhistone modifying activity

KAT6B CREBBP KMT2C KMT2D KMT2B

3.49e-07229145GO:0140993
GeneOntologyMolecularFunctiontranscription coactivator activity

KAT6B CREBBP KMT2C NCOA6 KMT2D

1.39e-06303145GO:0003713
GeneOntologyMolecularFunctionhistone H3 methyltransferase activity

KMT2C KMT2D KMT2B

3.57e-0644143GO:0140938
GeneOntologyMolecularFunctionprotein-lysine N-methyltransferase activity

KMT2C KMT2D KMT2B

1.34e-0568143GO:0016279
GeneOntologyMolecularFunctionlysine N-methyltransferase activity

KMT2C KMT2D KMT2B

1.40e-0569143GO:0016278
GeneOntologyMolecularFunctionhistone methyltransferase activity

KMT2C KMT2D KMT2B

1.52e-0571143GO:0042054
GeneOntologyMolecularFunctiontranscription coregulator activity

KAT6B CREBBP KMT2C NCOA6 KMT2D

2.81e-05562145GO:0003712
GeneOntologyMolecularFunctionprotein methyltransferase activity

KMT2C KMT2D KMT2B

4.66e-05103143GO:0008276
GeneOntologyMolecularFunctionhistone H3 acetyltransferase activity

KAT6B CREBBP

4.77e-0515142GO:0010484
GeneOntologyMolecularFunctionN-methyltransferase activity

KMT2C KMT2D KMT2B

4.93e-05105143GO:0008170
GeneOntologyMolecularFunctionperoxisome proliferator activated receptor binding

CREBBP NCOA6

9.51e-0521142GO:0042975
GeneOntologyMolecularFunctionS-adenosylmethionine-dependent methyltransferase activity

KMT2C KMT2D KMT2B

2.13e-04172143GO:0008757
GeneOntologyMolecularFunctionmethyltransferase activity

KMT2C KMT2D KMT2B

3.99e-04213143GO:0008168
GeneOntologyMolecularFunctiontransferase activity, transferring one-carbon groups

KMT2C KMT2D KMT2B

4.63e-04224143GO:0016741
GeneOntologyMolecularFunctionhistone acetyltransferase activity

KAT6B CREBBP

5.71e-0451142GO:0004402
GeneOntologyMolecularFunctionpeptide-lysine-N-acetyltransferase activity

KAT6B CREBBP

6.64e-0455142GO:0061733
GeneOntologyMolecularFunctionpeptide N-acetyltransferase activity

KAT6B CREBBP

7.89e-0460142GO:0034212
GeneOntologyMolecularFunctionprotein-macromolecule adaptor activity

KAT6B CREBBP KMT2C NCOA6 KMT2D

8.44e-041160145GO:0030674
GeneOntologyMolecularFunctionN-acetyltransferase activity

KAT6B CREBBP

1.33e-0378142GO:0008080
GeneOntologyMolecularFunctionchromatin binding

KAT6B CREBBP NCOA6 TOX4

1.38e-03739144GO:0003682
GeneOntologyMolecularFunctionmolecular adaptor activity

KAT6B CREBBP KMT2C NCOA6 KMT2D

1.71e-031356145GO:0060090
GeneOntologyMolecularFunctionN-acyltransferase activity

KAT6B CREBBP

2.26e-03102142GO:0016410
GeneOntologyMolecularFunctionacetyltransferase activity

KAT6B CREBBP

2.35e-03104142GO:0016407
GeneOntologyMolecularFunctionchromatin DNA binding

CREBBP TOX4

5.92e-03167142GO:0031490
GeneOntologyMolecularFunctionacyltransferase activity, transferring groups other than amino-acyl groups

KAT6B CREBBP

1.17e-02238142GO:0016747
GeneOntologyMolecularFunctionacyltransferase activity

KAT6B CREBBP KMT2C

1.54e-02775143GO:0016746
GeneOntologyBiologicalProcesschromatin remodeling

KAT6B CREBBP KMT2C PPHLN1 KMT2D KMT2B

4.94e-06741146GO:0006338
GeneOntologyBiologicalProcesschromatin organization

KAT6B CREBBP KMT2C PPHLN1 KMT2D KMT2B

1.47e-05896146GO:0006325
GeneOntologyBiologicalProcessprotein-DNA complex organization

KAT6B CREBBP KMT2C PPHLN1 KMT2D KMT2B

2.73e-05999146GO:0071824
GeneOntologyBiologicalProcessheterochromatin formation

PPHLN1 KMT2D KMT2B

1.65e-04163143GO:0031507
GeneOntologyBiologicalProcesspositive regulation of transcription by RNA polymerase II

HOXA4 KAT6B CREBBP KMT2C NCOA6 KMT2D

1.74e-041390146GO:0045944
GeneOntologyBiologicalProcessnegative regulation of gene expression, epigenetic

PPHLN1 KMT2D KMT2B

3.16e-04203143GO:0045814
GeneOntologyBiologicalProcessDNA methylation-dependent constitutive heterochromatin formation

PPHLN1 KMT2B

3.98e-0444142GO:0006346
GeneOntologyBiologicalProcessmethylation

KMT2C KMT2D KMT2B

4.78e-04234143GO:0032259
GeneOntologyBiologicalProcessfacultative heterochromatin formation

PPHLN1 KMT2B

6.22e-0455142GO:0140718
GeneOntologyCellularComponentMLL3/4 complex

KMT2C NCOA6 KMT2D

5.24e-0812143GO:0044666
GeneOntologyCellularComponenthistone methyltransferase complex

KMT2C NCOA6 KMT2D KMT2B

1.49e-0775144GO:0035097
GeneOntologyCellularComponentmethyltransferase complex

KMT2C NCOA6 KMT2D KMT2B

6.48e-07108144GO:0034708
GeneOntologyCellularComponenttransferase complex

KAT6B CREBBP KMT2C NCOA6 KMT2D KMT2B

2.05e-05963146GO:1990234
GeneOntologyCellularComponentnuclear protein-containing complex

CREBBP KMT2C NCOA6 KMT2D KMT2B

1.49e-031377145GO:0140513
GeneOntologyCellularComponenthistone acetyltransferase complex

KAT6B CREBBP

1.76e-0394142GO:0000123
GeneOntologyCellularComponentprotein acetyltransferase complex

KAT6B CREBBP

2.15e-03104142GO:0031248
GeneOntologyCellularComponentacetyltransferase complex

KAT6B CREBBP

2.35e-03109142GO:1902493
HumanPhenoMotor delay

KAT6B TANC2 MN1 CREBBP KMT2C KMT2D KMT2B

1.25e-05101877HP:0001270
HumanPhenoNatal tooth

CREBBP KMT2C KMT2D

1.31e-053873HP:0000695
HumanPhenoAbnormal earlobe morphology

CREBBP KMT2C KMT2D KMT2B

1.65e-0513774HP:0000363
HumanPhenoAdvanced eruption of teeth

CREBBP KMT2C KMT2D

2.35e-054673HP:0006288
HumanPhenoDelayed speech and language development

KAT6B TANC2 MN1 CREBBP KMT2C KMT2D KMT2B

2.49e-05112377HP:0000750
HumanPhenoAbnormality of calvarial morphology

KAT6B TANC2 MN1 CREBBP KMT2C KMT2D KMT2B

2.67e-05113477HP:0002648
HumanPhenoLanguage impairment

KAT6B TANC2 MN1 CREBBP KMT2C KMT2D KMT2B

3.49e-05117877HP:0002463
HumanPhenoAbnormal midface morphology

KAT6B MN1 CREBBP KMT2C KMT2D KMT2B

4.23e-0570476HP:0000309
HumanPhenoAbnormal calvaria morphology

KAT6B TANC2 MN1 CREBBP KMT2C KMT2D KMT2B

5.41e-05125477HP:0002683
HumanPhenoPrecocious puberty

CREBBP KMT2C KMT2D KMT2B

5.53e-0518674HP:0000826
HumanPhenoPilomatrixoma

CREBBP KMT2D

5.80e-05972HP:0030434
HumanPhenoEarly onset of sexual maturation

CREBBP KMT2C KMT2D KMT2B

5.89e-0518974HP:0100000
HumanPhenoAbnormal hallux morphology

KAT6B CREBBP KMT2D KMT2B

9.25e-0521274HP:0001844
HumanPhenoBroad hallux

CREBBP KMT2D KMT2B

1.07e-047673HP:0010055
HumanPhenoSupernumerary tooth

CREBBP KMT2C KMT2D

1.50e-048573HP:0011069
HumanPhenoAbnormality of dental eruption

KAT6B CREBBP KMT2C KMT2D

1.50e-0424074HP:0006292
HumanPhenoAbnormal nasolacrimal system morphology

KAT6B CREBBP KMT2D

1.60e-048773HP:0000614
HumanPhenoBroad toe

CREBBP KMT2D KMT2B

1.60e-048773HP:0001837
HumanPhenoReduced circulating growth hormone concentration

CREBBP KMT2D

1.69e-041572HP:0034323
HumanPhenoGastroesophageal reflux

KAT6B CREBBP KMT2C KMT2D KMT2B

1.87e-0451775HP:0002020
HumanPhenoPremature thelarche

CREBBP KMT2D

2.18e-041772HP:0010314
HumanPhenoSkin appendage neoplasm

CREBBP KMT2D

2.45e-041872HP:0012842
HumanPhenoAbnormal cheek morphology

KAT6B CREBBP KMT2D KMT2B

2.82e-0428274HP:0004426
HumanPhenoAbsent earlobe

CREBBP KMT2B

3.04e-042072HP:0000387
HumanPhenoThyroid hypoplasia

KAT6B KMT2D

4.04e-042372HP:0005990
HumanPhenoAplasia/Hypoplasia of the thyroid gland

KAT6B KMT2D

4.78e-042572HP:0033079
HumanPhenoAbnormal lateral ventricle morphology

KAT6B CREBBP KMT2D

5.16e-0412973HP:0030047
HumanPhenoThyroid dysgenesis

KAT6B KMT2D

5.18e-042672HP:0008188
HumanPhenoDepressed nasal ridge

MN1 CREBBP KMT2D

5.39e-0413173HP:0000457
HumanPhenoShort columella

CREBBP KMT2D

6.46e-042972HP:0002000
HumanPhenoAutistic behavior

TANC2 CREBBP KMT2C KMT2D KMT2B

6.86e-0467875HP:0000729
HumanPhenoAnal atresia

KAT6B KMT2C KMT2D

6.98e-0414373HP:0002023
HumanPhenoRetrognathia

KAT6B CREBBP KMT2D KMT2B

8.46e-0437574HP:0000278
HumanPhenoThick eyebrow

MN1 CREBBP KMT2C

8.67e-0415473HP:0000574
HumanPhenoAnal stenosis

KAT6B KMT2D

8.89e-043472HP:0002025
HumanPhenoAbnormality of tear glands or tear production

KAT6B CREBBP KMT2D

9.01e-0415673HP:0000521
HumanPhenoPatent ductus arteriosus

KAT6B CREBBP KMT2D KMT2B

9.08e-0438274HP:0001643
HumanPhenoSparse hair

KAT6B CREBBP KMT2D KMT2B

9.17e-0438374HP:0008070
HumanPhenoIntestinal malrotation

KAT6B CREBBP KMT2D

9.18e-0415773HP:0002566
HumanPhenoAbnormal palate morphology

KAT6B MN1 CREBBP KMT2C KMT2D KMT2B

9.56e-04120276HP:0000174
HumanPhenoHydrocele testis

CREBBP KMT2D

9.97e-043672HP:0000034
HumanPhenoNasolacrimal duct obstruction

CREBBP KMT2D

9.97e-043672HP:0000579
HumanPhenoAbnormal facial shape

KAT6B MN1 CREBBP KMT2C KMT2D KMT2B

1.05e-03122176HP:0001999
HumanPhenoAbnormal stomach morphology

KAT6B CREBBP KMT2C KMT2D KMT2B

1.05e-0374275HP:0002577
HumanPhenoAbnormality of hair density

KAT6B CREBBP KMT2D KMT2B

1.06e-0339874HP:0011357
HumanPhenoDiagnostic behavioral phenotype

TANC2 CREBBP KMT2C KMT2D KMT2B

1.09e-0374775HP:0025783
HumanPhenoBifid uvula

KAT6B KMT2C KMT2D

1.10e-0316773HP:0000193
HumanPhenoClinodactyly of the 5th finger

KAT6B CREBBP KMT2D KMT2B

1.30e-0342074HP:0004209
HumanPhenoClinodactyly of hands

KAT6B CREBBP KMT2D KMT2B

1.32e-0342174HP:0001157
HumanPhenoDeviation of the 5th finger

KAT6B CREBBP KMT2D KMT2B

1.32e-0342174HP:0009179
HumanPhenoAbnormality of thyroid physiology

KAT6B CREBBP KMT2D KMT2B

1.36e-0342574HP:0002926
HumanPhenoAbnormal antihelix morphology

KAT6B CREBBP

1.42e-034372HP:0009738
HumanPhenoAbnormality of the helix

KAT6B CREBBP KMT2D

1.43e-0318373HP:0000380
HumanPhenoMeningioma

MN1 CREBBP

1.49e-034472HP:0002858
HumanPhenoAbnormal pinna morphology

KAT6B MN1 CREBBP KMT2C KMT2D KMT2B

1.49e-03129976HP:0000377
HumanPhenoThird trimester onset

KMT2D KMT2B

1.56e-034572HP:0034197
HumanPhenoProminent fingertip pads

CREBBP KMT2D

1.63e-034672HP:0001212
HumanPhenoRadial deviation of finger

KAT6B CREBBP KMT2D KMT2B

1.67e-0344874HP:0009466
HumanPhenoFinger clinodactyly

KAT6B CREBBP KMT2D KMT2B

1.72e-0345274HP:0040019
HumanPhenoAbnormality of the outer ear

KAT6B MN1 CREBBP KMT2C KMT2D KMT2B

1.76e-03133776HP:0000356
HumanPhenoChiari type I malformation

CREBBP KMT2D

1.77e-034872HP:0007099
HumanPhenoProminent digit pad

CREBBP KMT2D

1.77e-034872HP:0011298
HumanPhenoAbnormal uvula morphology

KAT6B KMT2C KMT2D

1.78e-0319773HP:0000172
HumanPhenoRadial deviation of the hand or of fingers of the hand

KAT6B CREBBP KMT2D KMT2B

1.78e-0345674HP:0009485
HumanPhenoMicrocephaly

KAT6B TANC2 CREBBP KMT2C KMT2D KMT2B

1.79e-03134176HP:0000252
HumanPhenoHypoplastic left heart

CREBBP KMT2D

1.85e-034972HP:0004383
HumanPhenoBulbous nose

KAT6B KMT2D KMT2B

1.88e-0320173HP:0000414
HumanPhenoDecreased head circumference

KAT6B TANC2 CREBBP KMT2C KMT2D KMT2B

1.89e-03135476HP:0040195
HumanPhenoAbnormal lacrimal duct morphology

CREBBP KMT2D

1.92e-035072HP:0011481
HumanPhenoPosteriorly rotated ears

KAT6B MN1 KMT2D KMT2B

2.00e-0347074HP:0000358
HumanPhenoCongenital malformation of the left heart

CREBBP KMT2D

2.00e-035172HP:0045017
HumanPhenoHighly arched eyebrow

MN1 CREBBP KMT2D

2.02e-0320673HP:0002553
HumanPhenoAplasia/Hypoplasia of the earlobes

CREBBP KMT2B

2.16e-035372HP:0009906
HumanPhenoAbnormal helix morphology

KAT6B CREBBP KMT2D

2.20e-0321273HP:0011039
HumanPhenoHypoplastic heart

CREBBP KMT2D

2.24e-035472HP:0001961
HumanPhenoSingle transverse palmar crease

KAT6B CREBBP KMT2D

2.29e-0321573HP:0000954
HumanPhenoAbnormality of the palpebral fissures

KAT6B MN1 CREBBP KMT2C KMT2D

2.35e-0388075HP:0008050
HumanPhenoAbnormal eyelid morphology

KAT6B MN1 CREBBP KMT2C KMT2D KMT2B

2.37e-03140876HP:0000492
HumanPhenoExpressive language delay

KMT2C KMT2D

2.41e-035672HP:0002474
HumanPhenoLanguage delay

KMT2C KMT2D

2.41e-035672HP:0002336
HumanPhenoLow hanging columella

CREBBP KMT2D

2.41e-035672HP:0009765
HumanPhenoDownslanted palpebral fissures

KAT6B MN1 CREBBP KMT2D

2.46e-0349774HP:0000494
HumanPhenoVesicoureteral reflux

CREBBP KMT2C KMT2D

2.48e-0322173HP:0000076
HumanPhenoAbnormal hair morphology

KAT6B MN1 CREBBP KMT2C KMT2D KMT2B

2.52e-03142476HP:0001595
HumanPhenoAbnormal anus morphology

KAT6B KMT2C KMT2D

2.57e-0322473HP:0034915
HumanPhenoAbnormal 5th finger morphology

KAT6B CREBBP KMT2D KMT2B

2.70e-0350974HP:0004207
HumanPhenoAbnormal external nose morphology

KAT6B MN1 CREBBP KMT2D KMT2B

2.83e-0391675HP:0010938
HumanPhenoAbnormal palm morphology

KAT6B CREBBP KMT2D KMT2B

2.94e-0352174HP:0100871
HumanPhenoSparse or absent hair

KAT6B CREBBP KMT2D KMT2B

3.03e-0352574HP:0002115
HumanPhenoHypoplastic ilia

KAT6B CREBBP

3.04e-036372HP:0000946
HumanPhenoCleft soft palate

KAT6B KMT2C KMT2D

3.06e-0323873HP:0000185
HumanPhenoAbnormal esophagus physiology

KAT6B CREBBP KMT2C KMT2D KMT2B

3.09e-0393375HP:0025270
MousePhenoabnormal cranial suture morphology

KAT6B MN1 CREBBP

3.69e-0567143MP:0002835
MousePhenoabnormal craniofacial suture morphology

KAT6B MN1 CREBBP

4.21e-0570143MP:0030229
MousePhenoabnormal head morphology

KAT6B MN1 AMELY CREBBP NCOA6 KMT2D KMT2B

4.32e-051120147MP:0000432
MousePhenoflattened snout

CREBBP KMT2D

6.11e-0512142MP:0000447
MousePhenoabnormal occipital bone morphology

KAT6B MN1 CREBBP

1.05e-0495143MP:0005269
MousePhenoabnormal jaw morphology

KAT6B MN1 AMELY CREBBP KMT2D

1.16e-04530145MP:0000454
MousePhenoshort facial bone

KAT6B CREBBP KMT2D

1.37e-04104143MP:0030384
MousePhenoabnormal viscerocranium morphology

KAT6B MN1 AMELY CREBBP KMT2D

1.97e-04593145MP:0005274
MousePhenoabnormal fibrous joint morphology

KAT6B MN1 CREBBP

2.97e-04135143MP:0030878
MousePhenoabnormal maxilla morphology

MN1 CREBBP KMT2D

3.59e-04144143MP:0000455
MousePhenoabnormal joint morphology

HOXA4 KAT6B MN1 CREBBP

5.12e-04397144MP:0002932
MousePhenoprenatal lethality prior to heart atrial septation, incomplete penetrance

CREBBP KMT2C NCOA6 KMT2B

5.78e-04410144MP:0031660
MousePhenoembryonic lethality, incomplete penetrance

CREBBP KMT2C NCOA6 KMT2B

5.78e-04410144MP:0011102
MousePhenoshort maxilla

CREBBP KMT2D

6.76e-0439142MP:0000097
MousePhenooligodactyly

CREBBP NCOA6

6.76e-0439142MP:0000565
MousePhenoabnormal cranium morphology

KAT6B MN1 AMELY CREBBP KMT2D

8.46e-04813145MP:0000438
MousePhenoabnormal craniofacial bone morphology

KAT6B MN1 AMELY CREBBP KMT2D

9.15e-04827145MP:0002116
MousePhenothin myocardium compact layer

CREBBP NCOA6

9.40e-0446142MP:0004057
MousePhenoabnormal bile salt homeostasis

NCOA6 KMT2D

9.81e-0447142MP:0005365
MousePhenocraniofacial phenotype

KAT6B MN1 AMELY CREBBP NCOA6 KMT2D

1.33e-031372146MP:0005382
MousePhenoabnormal craniofacial morphology

KAT6B MN1 AMELY CREBBP NCOA6 KMT2D

1.33e-031372146MP:0000428
MousePhenoabnormal tooth number

AMELY CREBBP

1.39e-0356142MP:0030611
MousePhenoabnormal facial morphology

MN1 AMELY CREBBP NCOA6 KMT2D

1.41e-03910145MP:0003743
MousePhenofacial bone hypoplasia

MN1 CREBBP

1.44e-0357142MP:0030386
MousePhenosmall maxilla

CREBBP KMT2D

1.54e-0359142MP:0004540
MousePhenoincreased vertical activity

CREBBP KMT2D ERICH3

1.78e-03250143MP:0002574
MousePhenoabnormal parietal bone morphology

KAT6B MN1

1.81e-0364142MP:0000109
MousePhenoabnormal axial skeleton morphology

HOXA4 KAT6B MN1 AMELY CREBBP KMT2D

1.83e-031458146MP:0002114
MousePhenoabnormal myocardium compact layer morphology

CREBBP NCOA6

1.98e-0367142MP:0004056
MousePhenoabnormal neurocranium morphology

KAT6B MN1 CREBBP

2.19e-03269143MP:0000074
MousePhenoventricle myocardium hypoplasia

CREBBP NCOA6

2.23e-0371142MP:0010502
MousePhenoincreased grooming behavior

CREBBP KMT2D

2.41e-0374142MP:0001441
MousePhenoabnormal frontal bone morphology

MN1 CREBBP

2.61e-0377142MP:0000107
MousePhenoabnormal palatal shelf fusion at midline

MN1 NCOA6

2.81e-0380142MP:0009887
MousePhenoreduced female fertility

KMT2C NCOA6 KMT2B

2.88e-03296143MP:0001923
MousePhenodecreased percent body fat/body weight

KAT6B CREBBP

3.10e-0384142MP:0005459
MousePhenomyocardium hypoplasia

CREBBP NCOA6

3.24e-0386142MP:0010500
MousePhenoabnormal object recognition memory

CREBBP KMT2D

3.55e-0390142MP:0001458
MousePhenoabnormal mouth morphology

MN1 AMELY CREBBP NCOA6

3.56e-03670144MP:0000452
MousePhenolethality during fetal growth through weaning, incomplete penetrance

KAT6B MN1 CREBBP NCOA6 KMT2B

3.60e-031124145MP:0011112
MousePhenoabnormal palate morphology

MN1 CREBBP NCOA6

3.62e-03321143MP:0003755
MousePhenoperinatal lethality

MN1 CREBBP KMT2C NCOA6 KMT2B

3.69e-031130145MP:0002081
DomainFYrich_C

KMT2C KMT2D KMT2B

3.35e-095143IPR003889
DomainFYrich_N

KMT2C KMT2D KMT2B

3.35e-095143IPR003888
DomainFYRC

KMT2C KMT2D KMT2B

3.35e-095143SM00542
DomainFYRN

KMT2C KMT2D KMT2B

3.35e-095143SM00541
DomainFYRN

KMT2C KMT2D KMT2B

3.35e-095143PF05964
DomainFYRC

KMT2C KMT2D KMT2B

3.35e-095143PF05965
DomainFYRC

KMT2C KMT2D KMT2B

3.35e-095143PS51543
DomainFYRN

KMT2C KMT2D KMT2B

3.35e-095143PS51542
DomainPostSET

KMT2C KMT2D KMT2B

1.87e-0716143SM00508
DomainPost-SET_dom

KMT2C KMT2D KMT2B

1.87e-0716143IPR003616
DomainPOST_SET

KMT2C KMT2D KMT2B

1.87e-0716143PS50868
DomainPHD

KAT6B KMT2C KMT2D KMT2B

2.33e-0775144PF00628
DomainZnf_PHD-finger

KAT6B KMT2C KMT2D KMT2B

2.87e-0779144IPR019787
DomainPHD

KAT6B KMT2C KMT2D KMT2B

4.65e-0789144SM00249
DomainZnf_PHD

KAT6B KMT2C KMT2D KMT2B

5.09e-0791144IPR001965
DomainEPHD

KMT2C KMT2D KMT2B

5.12e-0722143PS51805
DomainZF_PHD_2

KAT6B KMT2C KMT2D KMT2B

6.05e-0795144PS50016
DomainZF_PHD_1

KAT6B KMT2C KMT2D KMT2B

6.31e-0796144PS01359
DomainZnf_FYVE_PHD

KAT6B KMT2C KMT2D KMT2B

3.47e-06147144IPR011011
DomainSET

KMT2C KMT2D KMT2B

3.51e-0641143PF00856
DomainSET

KMT2C KMT2D KMT2B

4.99e-0646143SM00317
DomainSET_dom

KMT2C KMT2D KMT2B

6.44e-0650143IPR001214
DomainSET

KMT2C KMT2D KMT2B

6.44e-0650143PS50280
DomainHMG_box

KMT2C KMT2D TOX4

7.68e-0653143PF00505
DomainHMG

KMT2C KMT2D TOX4

8.13e-0654143SM00398
DomainHMG_box_dom

KMT2C KMT2D TOX4

1.42e-0565143IPR009071
DomainAT_hook

KMT2C KMT2B

1.81e-0427142SM00384
DomainAT_hook_DNA-bd_motif

KMT2C KMT2B

1.81e-0427142IPR017956
Domain-

KAT6B KMT2C KMT2D KMT2B

2.72e-044491443.30.40.10
DomainZnf_RING/FYVE/PHD

KAT6B KMT2C KMT2D KMT2B

2.96e-04459144IPR013083
Domain-

KMT2D TOX4

7.57e-04551421.10.30.10
DomainZF_RING_2

KMT2C KMT2D

2.03e-02298142PS50089
DomainRING

KMT2C KMT2D

2.13e-02305142SM00184
DomainZnf_RING

KMT2C KMT2D

2.41e-02326142IPR001841
PathwayREACTOME_ACTIVATION_OF_ANTERIOR_HOX_GENES_IN_HINDBRAIN_DEVELOPMENT_DURING_EARLY_EMBRYOGENESIS

HOXA4 CREBBP KMT2C NCOA6 KMT2D

1.09e-08122105M29689
PathwayREACTOME_FORMATION_OF_WDR5_CONTAINING_HISTONE_MODIFYING_COMPLEXES

KMT2C NCOA6 KMT2D KMT2B

1.41e-0842104M48018
PathwayREACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION

KMT2C NCOA6 PPHLN1 KMT2D KMT2B

4.27e-07254105M27131
PathwayREACTOME_CHROMATIN_MODIFYING_ENZYMES

KAT6B CREBBP KMT2C KMT2D KMT2B

6.00e-07272105M29619
PathwayWP_HISTONE_MODIFICATIONS

KMT2C KMT2D KMT2B

1.10e-0565103M39374
PathwayREACTOME_PKMTS_METHYLATE_HISTONE_LYSINES

KMT2C KMT2D KMT2B

1.37e-0570103M27231
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX1

CREBBP KMT2C KMT2D KMT2B

1.51e-05237104M27786
PathwayREACTOME_RUNX1_REGULATES_GENES_INVOLVED_IN_MEGAKARYOCYTE_DIFFERENTIATION_AND_PLATELET_FUNCTION

KMT2C KMT2D KMT2B

3.55e-0596103M27792
PathwayREACTOME_RORA_ACTIVATES_GENE_EXPRESSION

CREBBP NCOA6

6.89e-0518102M26942
PathwayREACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_GENE_EXPRESSION

CREBBP NCOA6

1.57e-0427102M26943
PathwayWP_KLEEFSTRA_SYNDROME

KMT2C NCOA6

1.82e-0429102M48076
PathwayREACTOME_CHROMATIN_MODIFYING_ENZYMES

KAT6B KMT2D KMT2B

2.12e-04175103MM14941
PathwayREACTOME_FORMATION_OF_WDR5_CONTAINING_HISTONE_MODIFYING_COMPLEXES

KMT2D KMT2B

3.14e-0438102MM17073
PathwayREACTOME_ACTIVATION_OF_GENE_EXPRESSION_BY_SREBF_SREBP

CREBBP NCOA6

3.84e-0442102M27172
PathwayREACTOME_RUNX1_REGULATES_GENES_INVOLVED_IN_MEGAKARYOCYTE_DIFFERENTIATION_AND_PLATELET_FUNCTION

KMT2D KMT2B

4.22e-0444102MM15527
PathwayREACTOME_PKMTS_METHYLATE_HISTONE_LYSINES

KMT2D KMT2B

4.61e-0446102MM14933
PathwayREACTOME_HEME_SIGNALING

CREBBP NCOA6

5.23e-0449102M41832
PathwayREACTOME_TRANSCRIPTIONAL_ACTIVATION_OF_MITOCHONDRIAL_BIOGENESIS

CREBBP NCOA6

6.59e-0455102M27145
PathwayREACTOME_REGULATION_OF_CHOLESTEROL_BIOSYNTHESIS_BY_SREBP_SREBF

CREBBP NCOA6

6.59e-0455102M27001
PathwayREACTOME_CYTOPROTECTION_BY_HMOX1

CREBBP NCOA6

7.84e-0460102M41830
PathwayWP_PATHWAYS_AFFECTED_IN_ADENOID_CYSTIC_CARCINOMA

CREBBP KMT2C

9.20e-0465102M39682
PathwayREACTOME_CIRCADIAN_CLOCK

CREBBP NCOA6

1.07e-0370102M938
PathwayWP_16P112_PROXIMAL_DELETION_SYNDROME

KMT2C KMT2D

1.26e-0376102M40057
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_OF_WHITE_ADIPOCYTE_DIFFERENTIATION

CREBBP NCOA6

1.53e-0384102M1008
PathwayREACTOME_DEVELOPMENTAL_BIOLOGY

HOXA4 CREBBP KMT2C NCOA6 KMT2D

1.75e-031432105M509
PathwayREACTOME_FORMATION_OF_THE_BETA_CATENIN_TCF_TRANSACTIVATING_COMPLEX

CREBBP KMT2D

1.79e-0391102M27101
PathwayREACTOME_MITOCHONDRIAL_BIOGENESIS

CREBBP NCOA6

1.99e-0396102M26973
PathwayREACTOME_ADIPOGENESIS

CREBBP NCOA6

2.61e-03110102M48259
PathwayREACTOME_REGULATION_OF_LIPID_METABOLISM_BY_PPARALPHA

CREBBP NCOA6

2.99e-03118102M27316
PathwayREACTOME_EPIGENETIC_REGULATION_OF_GENE_EXPRESSION

KMT2D KMT2B

3.95e-03136102MM14848
PathwayREACTOME_HATS_ACETYLATE_HISTONES

KAT6B CREBBP

4.30e-03142102M27233
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_RUNX1

KMT2D KMT2B

4.97e-03153102MM15522
PathwayREACTOME_METABOLISM_OF_STEROIDS

CREBBP NCOA6

5.04e-03154102M27832
PathwayREACTOME_CELLULAR_RESPONSE_TO_CHEMICAL_STRESS

CREBBP NCOA6

9.19e-03210102M41836
PathwayREACTOME_TCF_DEPENDENT_SIGNALING_IN_RESPONSE_TO_WNT

CREBBP KMT2D

1.12e-02233102M27099
PathwayREACTOME_RNA_POLYMERASE_II_TRANSCRIPTION

CREBBP KMT2C KMT2D KMT2B

1.21e-021387104M734
PathwayREACTOME_ORGANELLE_BIOGENESIS_AND_MAINTENANCE

CREBBP NCOA6

1.78e-02297102M27050
PathwayWP_MECHANISMS_ASSOCIATED_WITH_PLURIPOTENCY

CREBBP KMT2D

1.83e-02301102MM15983
Pubmed

Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.

KMT2C NCOA6 KMT2D KMT2B

2.46e-13614417021013
Pubmed

ASCOM controls farnesoid X receptor transactivation through its associated histone H3 lysine 4 methyltransferase activity.

KMT2C NCOA6 KMT2D KMT2B

5.74e-13714419556342
Pubmed

Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.

CREBBP KMT2C NCOA6 KMT2D

1.64e-111414412482968
Pubmed

New nomenclature for chromatin-modifying enzymes.

KAT6B CREBBP KMT2C KMT2D KMT2B

1.96e-115714518022353
Pubmed

H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation.

KMT2C NCOA6 KMT2D KMT2B

2.98e-111614424368734
Pubmed

MLL3 and MLL4 Methyltransferases Bind to the MAFA and MAFB Transcription Factors to Regulate Islet β-Cell Function.

KMT2C NCOA6 KMT2D KMT2B

3.90e-111714426180087
Pubmed

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.

KMT2C NCOA6 KMT2D KMT2B

5.01e-111814417500065
Pubmed

Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis.

KMT2C NCOA6 KMT2D KMT2B

7.93e-112014419047629
Pubmed

Structural basis for activity regulation of MLL family methyltransferases.

KMT2C NCOA6 KMT2D KMT2B

1.20e-102214426886794
Pubmed

Crucial roles for interactions between MLL3/4 and INI1 in nuclear receptor transactivation.

KMT2C KMT2D KMT2B

2.08e-10414319221051
Pubmed

MLL3/MLL4 are required for CBP/p300 binding on enhancers and super-enhancer formation in brown adipogenesis.

CREBBP KMT2C KMT2D

2.08e-10414328398509
Pubmed

A subset of mixed lineage leukemia proteins has plant homeodomain (PHD)-mediated E3 ligase activity.

KMT2C KMT2D KMT2B

2.08e-10414323129768
Pubmed

Identification and characterization of a novel human PP1 phosphatase complex.

KMT2C KMT2D TOX4 KMT2B

5.14e-103114420516061
Pubmed

Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes.

KMT2C NCOA6 KMT2D TOX4 KMT2B

8.42e-1011914523508102
Pubmed

A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4.

KMT2C NCOA6 KMT2B

1.82e-09714319433796
Pubmed

Structural insights into trans-histone regulation of H3K4 methylation by unique histone H4 binding of MLL3/4.

KMT2C KMT2D KMT2B

1.82e-09714330604749
Pubmed

Skirting the pitfalls: a clear-cut nomenclature for H3K4 methyltransferases.

KMT2C KMT2D KMT2B

2.90e-09814323130995
Pubmed

The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.

KMT2C KMT2D KMT2B

2.90e-09814322266653
Pubmed

The Epigenetic Factor Landscape of Developing Neocortex Is Regulated by Transcription Factors Pax6→ Tbr2→ Tbr1.

KAT6B CREBBP NCOA6 KMT2D KMT2B

3.41e-0915714530186101
Pubmed

Epigenetic-focused CRISPR/Cas9 screen identifies (absent, small, or homeotic)2-like protein (ASH2L) as a regulator of glioblastoma cell survival.

KMT2C NCOA6 KMT2D KMT2B

3.74e-095014437974198
Pubmed

Structural basis for WDR5 interaction (Win) motif recognition in human SET1 family histone methyltransferases.

KMT2C KMT2D KMT2B

4.36e-09914322665483
Pubmed

Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus.

CREBBP KMT2D KMT2B

1.14e-081214317707229
Pubmed

Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.

KMT2C KMT2D KMT2B

1.14e-081214327563068
Pubmed

Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.

KMT2C NCOA6 KMT2D

1.48e-081314317761849
Pubmed

Histone demethylase JMJD2B coordinates H3K4/H3K9 methylation and promotes hormonally responsive breast carcinogenesis.

KMT2C KMT2D KMT2B

1.48e-081314321502505
Pubmed

The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex.

KMT2C NCOA6 KMT2D

2.36e-081514317925232
Pubmed

SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53.

KMT2C NCOA6 KMT2B

2.90e-081614323870121
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

CREBBP KMT2C NCOA6 KMT2D TOX4 KMT2B

4.06e-0854914638280479
Pubmed

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.

KMT2C NCOA6 KMT2D

5.90e-082014329785026
Pubmed

Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.

KMT2C KMT2D KMT2B

6.88e-082114327626377
Pubmed

Mll3 and Mll4 Facilitate Enhancer RNA Synthesis and Transcription from Promoters Independently of H3K4 Monomethylation.

KMT2C KMT2D

1.50e-07214228483418
Pubmed

Loss of MLL3/4 decouples enhancer H3K4 monomethylation, H3K27 acetylation, and gene activation during embryonic stem cell differentiation.

KMT2C KMT2D

1.50e-07214236869380
Pubmed

Crucial roles of mixed-lineage leukemia 3 and 4 as epigenetic switches of the hepatic circadian clock controlling bile acid homeostasis in mice.

KMT2C KMT2D

1.50e-07214225346535
Pubmed

Kabuki syndrome stem cell models reveal locus specificity of histone methyltransferase 2D (KMT2D/MLL4).

KMT2D KMT2B

1.50e-07214235640156
Pubmed

Comparison of methylation episignatures in KMT2B- and KMT2D-related human disorders.

KMT2D KMT2B

1.50e-07214235506254
Pubmed

Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability.

KMT2C KMT2D

1.50e-07214228967912
Pubmed

A ketogenic diet rescues hippocampal memory defects in a mouse model of Kabuki syndrome.

CREBBP KMT2D

1.50e-07214227999180
Pubmed

KMT2C/D COMPASS complex-associated diseases [KCDCOM-ADs]: an emerging class of congenital regulopathies.

KMT2C KMT2D

1.50e-07214231924266
Pubmed

The MLL3/4 H3K4 methyltransferase complex in establishing an active enhancer landscape.

KMT2C KMT2D

1.50e-07214234156443
Pubmed

Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma.

KMT2C KMT2D

1.50e-07214227280393
Pubmed

Fusion of the MORF and CBP genes in acute myeloid leukemia with the t(10;16)(q22;p13).

KAT6B CREBBP

1.50e-07214211157802
Pubmed

Association of KMT2C/D loss-of-function variants with response to immune checkpoint blockades in colorectal cancer.

KMT2C KMT2D

1.50e-07214236601880
Pubmed

Menin and Menin-Associated Proteins Coregulate Cancer Energy Metabolism.

KAT6B NCOA6 MYEF2 KMT2D TOX4

1.64e-0734114532971831
Pubmed

Interaction network of human early embryonic transcription factors.

CREBBP KMT2C NCOA6 KMT2D KMT2B

1.89e-0735114538297188
Pubmed

Activating signal cointegrator-2 is an essential adaptor to recruit histone H3 lysine 4 methyltransferases MLL3 and MLL4 to the liver X receptors.

KMT2C NCOA6

4.51e-07314218372346
Pubmed

Histone H3K4 trimethylation by MLL3 as part of ASCOM complex is critical for NR activation of bile acid transporter genes and is downregulated in cholestasis.

KMT2C NCOA6

4.51e-07314221330447
Pubmed

Leveraging the Mendelian disorders of the epigenetic machinery to systematically map functional epigenetic variation.

CREBBP KMT2D

4.51e-07314234463256
Pubmed

Coactivator ASC-2 mediates heat shock factor 1-mediated transactivation dependent on heat shock.

CREBBP NCOA6

4.51e-07314214960326
Pubmed

The histone methyltransferase KMT2B is required for RNA polymerase II association and protection from DNA methylation at the MagohB CpG island promoter.

KMT2D KMT2B

4.51e-07314223358417
Pubmed

Mutations of PTCH1, MLL2, and MLL3 are not frequent events in hepatoblastoma.

KMT2C KMT2D

4.51e-07314222183980
Pubmed

Histone methyltransferase MLL4 controls myofiber identity and muscle performance through MEF2 interaction.

KMT2D KMT2B

4.51e-07314232544095
Pubmed

Remodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription.

KMT2C KMT2D

4.51e-07314223932714
Pubmed

KMT2D acetylation by CREBBP reveals a cooperative functional interaction at enhancers in normal and malignant germinal center B cells.

CREBBP KMT2D

4.51e-07314236893259
Pubmed

HOXC6 Is transcriptionally regulated via coordination of MLL histone methylase and estrogen receptor in an estrogen environment.

KMT2C KMT2D

4.51e-07314221683083
Pubmed

Impact of WIN site inhibitor on the WDR5 interactome.

KMT2C KMT2D KMT2B

6.35e-074314333472061
Pubmed

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.

CREBBP KMT2C NCOA6 MYEF2 KMT2D

6.96e-0745714532344865
Pubmed

Cancer gene mutation frequencies for the U.S. population.

KMT2C KMT2D

9.02e-07414234645806
Pubmed

MLL2 is required in oocytes for bulk histone 3 lysine 4 trimethylation and transcriptional silencing.

KMT2D KMT2B

9.02e-07414220808952
Pubmed

The MLL3/MLL4 branches of the COMPASS family function as major histone H3K4 monomethylases at enhancers.

KMT2C KMT2D

9.02e-07414224081332
Pubmed

Mutations in Mll2, an H3K4 methyltransferase, result in insulin resistance and impaired glucose tolerance in mice.

KMT2D KMT2B

9.02e-07414223826075
Pubmed

Evolving Catalytic Properties of the MLL Family SET Domain.

KMT2D KMT2B

1.50e-06514226320581
Pubmed

Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF.

KMT2C KMT2D

1.50e-06514231127101
Pubmed

MLL2, Not MLL1, Plays a Major Role in Sustaining MLL-Rearranged Acute Myeloid Leukemia.

KMT2D KMT2B

1.50e-06514228609655
Pubmed

MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by Controlling Induction of C/EBPβ and C/EBPδ.

KMT2C KMT2D

1.50e-06514232601106
Pubmed

Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation.

CREBBP NCOA6

1.50e-06514211912212
Pubmed

A PTIP-PA1 subcomplex promotes transcription for IgH class switching independently from the associated MLL3/MLL4 methyltransferase complex.

KMT2C KMT2D

1.50e-06514226744420
Pubmed

Human GW182 Paralogs Are the Central Organizers for RNA-Mediated Control of Transcription.

KMT2C NCOA6 KMT2B

1.67e-065914328813667
Pubmed

MLL associates specifically with a subset of transcriptionally active target genes.

KMT2D KMT2B

2.25e-06614216199523
Pubmed

Transcription coactivator PBP, the peroxisome proliferator-activated receptor (PPAR)-binding protein, is required for PPARalpha-regulated gene expression in liver.

CREBBP NCOA6

2.25e-06614215150259
Pubmed

Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment.

CREBBP KMT2D

2.25e-06614238570506
Pubmed

Cleavage of TFIIA by Taspase1 activates TRF2-specified mammalian male germ cell programs.

KMT2D KMT2B

2.25e-06614224176642
Pubmed

Functional proteomics mapping of a human signaling pathway.

CREBBP NCOA6 KMT2D TOX4 KMT2B

2.46e-0659114515231748
Pubmed

SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.

KMT2C KMT2D TOX4 KMT2B

2.50e-0625114431076518
Pubmed

Clustered PHD domains in KMT2/MLL proteins are attracted by H3K4me3 and H3 acetylation-rich active promoters and enhancers.

KMT2C KMT2D

3.16e-06714236598580
Pubmed

Multiple epigenetic maintenance factors implicated by the loss of Mll2 in mouse development.

KMT2D KMT2B

3.16e-06714216540515
Pubmed

Regulation of transcription by the MLL2 complex and MLL complex-associated AKAP95.

KMT2D KMT2B

3.16e-06714223995757
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

TANC2 CREBBP NCOA6 MYEF2 KMT2D

3.57e-0663814531182584
Pubmed

H3.3K4M destabilizes enhancer H3K4 methyltransferases MLL3/MLL4 and impairs adipose tissue development.

KMT2C KMT2D

4.21e-06814230335158
Pubmed

Nuclear receptor coactivator 6 mediates the synergistic activation of human cytochrome P-450 2C9 by the constitutive androstane receptor and hepatic nuclear factor-4alpha.

CREBBP NCOA6

4.21e-06814218552123
Pubmed

Four enzymes cooperate to displace histone H1 during the first minute of hormonal gene activation.

KMT2C KMT2D

4.21e-06814221447625
Pubmed

Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth.

NCOA6 KMT2D

4.21e-06814217178841
Pubmed

Proteolysis of MLL family proteins is essential for taspase1-orchestrated cell cycle progression.

KMT2D KMT2B

5.41e-06914216951254
Pubmed

H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.

KMT2C NCOA6 PPHLN1 KMT2D TOX4 KMT2B

6.09e-06129414630804502
Pubmed

MLL3/MLL4 methyltransferase activities control early embryonic development and embryonic stem cell differentiation in a lineage-selective manner.

KMT2C KMT2D

8.26e-061114237012455
Pubmed

Large-scale characterization of HeLa cell nuclear phosphoproteins.

KAT6B MN1 NCOA6 KMT2D KMT2B

9.13e-0677414515302935
Pubmed

A new family of nuclear receptor coregulators that integrate nuclear receptor signaling through CREB-binding protein.

CREBBP NCOA6

9.91e-061214210866662
Pubmed

Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2.

CREBBP NCOA6

9.91e-061214211158331
Pubmed

Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivator.

CREBBP NCOA6

9.91e-061214212189208
Pubmed

Ubiquitin-Independent Disassembly by a p97 AAA-ATPase Complex Drives PP1 Holoenzyme Formation.

TANC2 CREBBP PPHLN1 TOX4

1.05e-0536114430344098
Pubmed

Dynamic patterns of histone H3 lysine 4 methyltransferases and demethylases during mouse preimplantation development.

KMT2C KMT2B

1.17e-051314224619213
Pubmed

A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo.

CREBBP NCOA6

1.58e-051514210567404
Pubmed

Structural analysis of the KANSL1/WDR5/KANSL2 complex reveals that WDR5 is required for efficient assembly and chromatin targeting of the NSL complex.

KMT2D KMT2B

1.80e-051614224788516
Pubmed

Adipocyte arrestin domain-containing 3 protein (Arrdc3) regulates uncoupling protein 1 (Ucp1) expression in white adipose independently of canonical changes in β-adrenergic receptor signaling.

CREBBP NCOA6

2.04e-051714228291835
Pubmed

A direct physical interaction between Nanog and Sox2 regulates embryonic stem cell self-renewal.

KMT2C MYEF2 KMT2B

2.55e-0514614323892456
Pubmed

Early embryonic lethality of mice with disrupted transcription cofactor PIMT/NCOA6IP/Tgs1 gene.

CREBBP NCOA6

2.56e-051914222982455
Pubmed

The histone H3-lysine 4-methyltransferase Mll4 regulates the development of growth hormone-releasing hormone-producing neurons in the mouse hypothalamus.

KMT2C KMT2D

2.85e-052014233431871
Pubmed

FBXW7 Triggers Degradation of KMT2D to Favor Growth of Diffuse Large B-cell Lymphoma Cells.

NCOA6 KMT2D

2.85e-052014232350066
Pubmed

T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities.

CREBBP NCOA6

2.85e-052014211877444
Pubmed

Nuclear receptor-coregulator interaction profiling identifies TRIP3 as a novel peroxisome proliferator-activated receptor gamma cofactor.

CREBBP NCOA6

3.15e-052114219596656
Pubmed

A High-Density Map for Navigating the Human Polycomb Complexome.

KMT2C NCOA6 KMT2D KMT2B

3.62e-0549514427705803
InteractionNCOA6 interactions

CREBBP KMT2C NCOA6 KMT2D KMT2B

3.42e-08145145int:NCOA6
InteractionPAGR1 interactions

KMT2C NCOA6 KMT2D KMT2B

3.57e-0851144int:PAGR1
InteractionKDM6A interactions

CREBBP KMT2C NCOA6 KMT2D KMT2B

5.96e-08162145int:KDM6A
InteractionKMT2D interactions

CREBBP KMT2C NCOA6 KMT2D KMT2B

7.36e-08169145int:KMT2D
InteractionSETD1A interactions

CREBBP KMT2C NCOA6 KMT2D KMT2B

7.58e-08170145int:SETD1A
InteractionMEN1 interactions

KAT6B KMT2C NCOA6 PPHLN1 MYEF2 KMT2D TOX4 KMT2B

1.03e-071029148int:MEN1
InteractionSETD1B interactions

KMT2C NCOA6 KMT2D KMT2B

1.72e-0775144int:SETD1B
InteractionFEV interactions

CREBBP KMT2C NCOA6 KMT2D KMT2B

1.84e-07203145int:FEV
InteractionWDR82 interactions

KMT2C NCOA6 KMT2D TOX4 KMT2B

2.33e-07213145int:WDR82
InteractionHCFC2 interactions

KMT2C NCOA6 KMT2D KMT2B

3.93e-0792144int:HCFC2
InteractionUTY interactions

KMT2C NCOA6 KMT2D

4.69e-0723143int:UTY
InteractionSOX9 interactions

CREBBP KMT2C NCOA6 KMT2D

4.86e-0797144int:SOX9
InteractionHNF4A interactions

CREBBP KMT2C NCOA6 KMT2D KMT2B

8.26e-07275145int:HNF4A
InteractionTBXT interactions

CREBBP KMT2C NCOA6 KMT2D

9.98e-07116144int:TBXT
InteractionRBBP5 interactions

CREBBP KMT2C NCOA6 KMT2D KMT2B

1.02e-06287145int:RBBP5
InteractionSP7 interactions

CREBBP KMT2C NCOA6 KMT2D KMT2B

1.35e-06304145int:SP7
InteractionKMT2B interactions

KMT2C NCOA6 KMT2D KMT2B

1.57e-06130144int:KMT2B
InteractionKMT2A interactions

CREBBP KMT2C NCOA6 KMT2D KMT2B

1.59e-06314145int:KMT2A
InteractionCXXC1 interactions

KMT2C NCOA6 KMT2D KMT2B

1.67e-06132144int:CXXC1
InteractionKMT2C interactions

KMT2C NCOA6 KMT2D KMT2B

1.78e-06134144int:KMT2C
InteractionELF5 interactions

KMT2C PPHLN1 MYEF2 KMT2D

2.57e-06147144int:ELF5
InteractionBOD1L1 interactions

KMT2C NCOA6 KMT2D KMT2B

2.71e-06149144int:BOD1L1
InteractionPAXIP1 interactions

KMT2C NCOA6 PPHLN1 KMT2D KMT2B

3.06e-06359145int:PAXIP1
InteractionH3C14 interactions

KMT2C NCOA6 KMT2D KMT2B

3.26e-06156144int:H3C14
InteractionPAX6 interactions

HOXA4 CREBBP KMT2C NCOA6 KMT2D

3.36e-06366145int:PAX6
InteractionEGR2 interactions

CREBBP KMT2C NCOA6 KMT2D

4.69e-06171144int:EGR2
InteractionNUP35 interactions

CREBBP KMT2C NCOA6 MYEF2 KMT2D

6.89e-06424145int:NUP35
InteractionTPRX2 interactions

CREBBP NCOA6 KMT2D

7.24e-0656143int:TPRX2
InteractionKLF5 interactions

CREBBP KMT2C NCOA6 KMT2D

7.89e-06195144int:KLF5
InteractionGATA2 interactions

CREBBP KMT2C NCOA6 KMT2D

8.55e-06199144int:GATA2
InteractionDPY30 interactions

KMT2C NCOA6 KMT2D KMT2B

9.43e-06204144int:DPY30
InteractionGCM1 interactions

CREBBP KMT2C KMT2D

1.30e-0568143int:GCM1
InteractionERG interactions

CREBBP KMT2C NCOA6 KMT2D

1.34e-05223144int:ERG
InteractionHNF1A interactions

CREBBP KMT2C KMT2D

2.12e-0580143int:HNF1A
InteractionPPARGC1A interactions

CREBBP NCOA6 MYEF2

2.29e-0582143int:PPARGC1A
InteractionSOX7 interactions

CREBBP KMT2C KMT2D

2.29e-0582143int:SOX7
InteractionNFE2 interactions

HOXA4 CREBBP KMT2D

2.46e-0584143int:NFE2
InteractionASH2L interactions

KMT2C NCOA6 KMT2D KMT2B

2.64e-05265144int:ASH2L
InteractionGSC interactions

CREBBP KMT2C KMT2D

2.73e-0587143int:GSC
InteractionFOXI1 interactions

CREBBP KMT2C KMT2D

3.23e-0592143int:FOXI1
InteractionASCL2 interactions

KMT2C NCOA6

3.48e-0513142int:ASCL2
InteractionSOX17 interactions

KMT2C NCOA6 KMT2D

3.56e-0595143int:SOX17
InteractionHCFC1 interactions

KMT2C NCOA6 KMT2D KMT2B

3.91e-05293144int:HCFC1
InteractionPPARG interactions

CREBBP KMT2C NCOA6 KMT2D

4.69e-05307144int:PPARG
InteractionFOS interactions

CREBBP KMT2C NCOA6 KMT2D

4.99e-05312144int:FOS
InteractionYAP1 interactions

CREBBP KMT2C NCOA6 KMT2D TOX4 KMT2B

5.23e-051095146int:YAP1
InteractionPAX8 interactions

CREBBP KMT2C KMT2D

5.66e-05111143int:PAX8
InteractionH2BC21 interactions

KAT6B CREBBP PPHLN1 TOX4 KMT2B

7.48e-05696145int:H2BC21
InteractionPAX7 interactions

CREBBP KMT2C KMT2D

7.88e-05124143int:PAX7
InteractionPAX9 interactions

KMT2C NCOA6 KMT2D

9.06e-05130143int:PAX9
InteractionHOXB4 interactions

HOXA4 CREBBP

9.34e-0521142int:HOXB4
InteractionMYB interactions

CREBBP KMT2D KMT2B

9.70e-05133143int:MYB
InteractionNFIB interactions

CREBBP KMT2C KMT2D

1.18e-04142143int:NFIB
InteractionSNIP1 interactions

KAT6B TANC2 CREBBP TOX4

1.53e-04417144int:SNIP1
InteractionMAFA interactions

NCOA6 KMT2D

1.56e-0427142int:MAFA
InteractionWWTR1 interactions

CREBBP NCOA6 KMT2D TOX4

1.61e-04422144int:WWTR1
InteractionKLF4 interactions

CREBBP KMT2C KMT2D

1.68e-04160143int:KLF4
InteractionTLX1 interactions

CREBBP KMT2C KMT2D

2.18e-04175143int:TLX1
InteractionTEAD1 interactions

CREBBP KMT2C KMT2D

2.22e-04176143int:TEAD1
InteractionH3C1 interactions

KAT6B CREBBP KMT2C KMT2D KMT2B

2.52e-04901145int:H3C1
InteractionLHX3 interactions

CREBBP KMT2C KMT2D

2.57e-04185143int:LHX3
InteractionGATA3 interactions

CREBBP KMT2D TOX4

2.65e-04187143int:GATA3
InteractionATN1 interactions

KAT6B KMT2C KMT2B

2.65e-04187143int:ATN1
InteractionHNF1B interactions

CREBBP KMT2C KMT2D

2.78e-04190143int:HNF1B
InteractionE2F5 interactions

CREBBP KMT2D

2.79e-0436142int:E2F5
InteractionHOXB2 interactions

CREBBP KMT2D

2.79e-0436142int:HOXB2
InteractionMAFK interactions

CREBBP KMT2D

2.94e-0437142int:MAFK
InteractionMYOD1 interactions

CREBBP KMT2C KMT2D

2.96e-04194143int:MYOD1
InteractionSTAT4 interactions

CREBBP KMT2D

3.11e-0438142int:STAT4
InteractionNR3C1 interactions

TANC2 CREBBP NCOA6 MYEF2 KMT2D

3.62e-04974145int:NR3C1
InteractionAR interactions

CREBBP KMT2C NCOA6 MYEF2 KMT2D

3.94e-04992145int:AR
InteractionHIPK3 interactions

CREBBP TOX4

4.17e-0444142int:HIPK3
InteractionNFIX interactions

KMT2C KMT2D KMT2B

4.68e-04227143int:NFIX
InteractionRXRG interactions

CREBBP NCOA6

4.76e-0447142int:RXRG
InteractionPYGO2 interactions

CREBBP KMT2D

4.96e-0448142int:PYGO2
InteractionBUB3 interactions

KMT2C KMT2D KMT2B

4.99e-04232143int:BUB3
InteractionSMAD1 interactions

CREBBP NCOA6 KMT2D

5.71e-04243143int:SMAD1
InteractionPHF20 interactions

KMT2C KMT2B

6.05e-0453142int:PHF20
InteractionASF1A interactions

NCOA6 KMT2D KMT2B

6.13e-04249143int:ASF1A
InteractionWDR5 interactions

CREBBP KMT2C NCOA6 KMT2D KMT2B

6.38e-041101145int:WDR5
InteractionCRX interactions

CREBBP KMT2C KMT2D

6.50e-04254143int:CRX
InteractionNUP43 interactions

NCOA6 PPHLN1 KMT2D KMT2B

7.16e-04625144int:NUP43
InteractionMKI67 interactions

NCOA6 PPHLN1 KMT2D TOX4

8.19e-04648144int:MKI67
InteractionTNRC6A interactions

KMT2C NCOA6 KMT2B

8.62e-04280143int:TNRC6A
InteractionKLF15 interactions

CREBBP KMT2C KMT2D

9.54e-04290143int:KLF15
InteractionTLX3 interactions

KMT2C NCOA6 KMT2D

9.64e-04291143int:TLX3
InteractionETV4 interactions

CREBBP KMT2D

1.02e-0369142int:ETV4
InteractionKDM4B interactions

KMT2C KMT2D

1.08e-0371142int:KDM4B
InteractionCEBPA interactions

CREBBP KMT2C NCOA6 KMT2D KMT2B

1.12e-031245145int:CEBPA
InteractionPHF20L1 interactions

KMT2C KMT2B

1.21e-0375142int:PHF20L1
InteractionTGS1 interactions

CREBBP NCOA6

1.21e-0375142int:TGS1
InteractionPPP1R21 interactions

KMT2D TOX4

1.21e-0375142int:PPP1R21
InteractionSMG7 interactions

CREBBP NCOA6 KMT2D

1.26e-03319143int:SMG7
InteractionJADE1 interactions

KAT6B CREBBP

1.27e-0377142int:JADE1
InteractionPPP1CC interactions

TANC2 CREBBP PPHLN1 TOX4

1.33e-03738144int:PPP1CC
InteractionE2F3 interactions

CREBBP KMT2D

1.34e-0379142int:E2F3
InteractionKLF8 interactions

CREBBP KMT2D KMT2B

1.37e-03329143int:KLF8
InteractionH3-3A interactions

CREBBP KMT2C KMT2D KMT2B

1.41e-03749144int:H3-3A
InteractionPHF21A interactions

KMT2D TOX4 KMT2B

1.55e-03343143int:PHF21A
GeneFamilyPHD finger proteins

KAT6B KMT2C KMT2D KMT2B

3.96e-08908488
GeneFamilyZinc fingers C2H2-type|Lysine methyltransferases|PR/SET domain family

KMT2C KMT2D KMT2B

3.38e-073483487
GeneFamilyZinc fingers ZZ-type|Lysine acetyltransferases

KAT6B CREBBP

2.32e-051782486
CoexpressionLAKE_ADULT_KIDNEY_C5_PROXIMAL_TUBULE_EPITHELIAL_CELLS_STRESS_INFLAM

KAT6B TANC2 CREBBP KMT2B

5.57e-05417144M39224
CoexpressionGSE21033_CTRL_VS_POLYIC_STIM_DC_6H_DN

KAT6B CREBBP KMT2D

7.31e-05157143M7733
CoexpressionSCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN

CREBBP KMT2C NCOA6 PPHLN1

8.64e-05467144M1347
CoexpressionSCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN

CREBBP KMT2C NCOA6 PPHLN1

9.92e-05484144MM999
CoexpressionGSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP

CREBBP KMT2C KMT2B

1.10e-04180143M8239
CoexpressionGSE3982_MEMORY_CD4_TCELL_VS_TH2_UP

KAT6B NCOA6 KMT2D

1.41e-04196143M5381
CoexpressionGSE360_CTRL_VS_B_MALAYI_LOW_DOSE_DC_UP

AMELY NCOA6 MYEF2

1.45e-04198143M5152
CoexpressionGSE22886_NAIVE_CD4_TCELL_VS_12H_ACT_TH2_UP

KAT6B MN1 CREBBP

1.48e-04199143M4526
CoexpressionGSE15324_NAIVE_VS_ACTIVATED_CD8_TCELL_UP

MN1 CREBBP KMT2C

1.50e-04200143M3523
CoexpressionGSE40655_FOXO1_KO_VS_WT_NTREG_UP

KMT2C NCOA6 KMT2D

1.50e-04200143M9439
CoexpressionGSE27786_ERYTHROBLAST_VS_NEUTROPHIL_DN

NCOA6 PPHLN1 KMT2D

1.50e-04200143M4876
CoexpressionKRASNOSELSKAYA_ILF3_TARGETS_DN

MN1 CREBBP

2.71e-0446142M12166
CoexpressionDAZARD_RESPONSE_TO_UV_NHEK_DN

KAT6B MN1 CREBBP

4.92e-04300143M8702
CoexpressionGRESHOCK_CANCER_COPY_NUMBER_UP

KAT6B MN1 CREBBP

6.10e-04323143M9150
DrugTrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A

KAT6B CREBBP NCOA6 KMT2B

3.11e-061741441659_DN
DrugSAHA; Down 200; 10uM; MCF7; HT_HG-U133A

KAT6B CREBBP NCOA6 KMT2B

3.33e-061771441645_DN
DrugHBGG

AMELY NCOA6

8.05e-0522142CID000125044
Drug1,1,1-trichloroethane

CREBBP NCOA6 MYEF2

1.09e-04156143CID000006278
DrugTrichostatin A, Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA

KAT6B CREBBP NCOA6

1.40e-041701431050_DN
DrugTrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A_EA

KAT6B CREBBP NCOA6

1.45e-041721431072_DN
DrugTrichostatin A, Streptomyces sp.; Down 200; 1uM; MCF7; HT_HG-U133A_EA

KAT6B CREBBP NCOA6

1.53e-041751431014_DN
DrugSAHA; Down 200; 10uM; MCF7; HT_HG-U133A_EA

KAT6B CREBBP NCOA6

1.53e-041751431058_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A

KAT6B CREBBP NCOA6

1.61e-041781437245_DN
DrugTrichostatin A, Streptomyces sp.; Down 200; 0.1uM; MCF7; HT_HG-U133A_EA

KAT6B CREBBP NCOA6

1.61e-041781431112_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HG-U133A

KAT6B CREBBP NCOA6

1.71e-041821431891_DN
DrugTrichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HG-U133A

KAT6B CREBBP NCOA6

1.71e-041821431951_DN
Drug5155877; Down 200; 10uM; MCF7; HT_HG-U133A

KAT6B TANC2 KMT2B

2.16e-041971436549_DN
DiseaseKleefstra syndrome 2 (implicated_via_orthology)

KMT2C KMT2D

2.09e-072142DOID:0080598 (implicated_via_orthology)
DiseaseSezary Syndrome

CREBBP KMT2C KMT2D

2.47e-0727143C0036920
Diseasecongenital heart disease (implicated_via_orthology)

KMT2C KMT2D KMT2B

4.37e-0669143DOID:1682 (implicated_via_orthology)
DiseaseSquamous cell carcinoma of esophagus

CREBBP KMT2C KMT2D

1.15e-0595143C0279626
DiseaseLymphoma, Large-Cell, Follicular

CREBBP KMT2D

2.19e-0515142C0079745
DiseaseLymphoma, Follicular, Grade 2

CREBBP KMT2D

2.19e-0515142C1956132
DiseaseLymphoma, Follicular, Grade 3

CREBBP KMT2D

2.19e-0515142C1956131
DiseaseLymphoma, Follicular, Grade 1

CREBBP KMT2D

2.19e-0515142C1956130
DiseaseLymphoma, Small Cleaved-Cell, Follicular

CREBBP KMT2D

2.19e-0515142C0079765
DiseaseLymphoma, Mixed-Cell, Follicular

CREBBP KMT2D

2.19e-0515142C0079758
DiseaseBladder Neoplasm

CREBBP KMT2C KMT2D

3.66e-05140143C0005695
DiseaseMalignant neoplasm of urinary bladder

CREBBP KMT2C KMT2D

3.74e-05141143C0005684
DiseaseLymphoma, Follicular

CREBBP KMT2D

3.95e-0520142C0024301
Diseaseprostate cancer (is_marker_for)

KMT2C KMT2D KMT2B

5.06e-05156143DOID:10283 (is_marker_for)
DiseaseLeukemia, Myelocytic, Acute

MN1 CREBBP KMT2C

6.88e-05173143C0023467
DiseaseMalignant neoplasm of breast

HOXA4 KAT6B NCOA6 PPHLN1 KMT2D

9.63e-051074145C0006142
DiseaseCarcinoma, Transitional Cell

CREBBP KMT2C

1.70e-0441142C0007138
Diseaseesophagus squamous cell carcinoma (is_implicated_in)

KMT2C KMT2D

2.05e-0445142DOID:3748 (is_implicated_in)
DiseaseDiffuse Large B-Cell Lymphoma

CREBBP KMT2D

3.06e-0455142C0079744
DiseaseNeurodevelopmental Disorders

TANC2 KMT2C

8.72e-0493142C1535926
DiseaseAdenoid Cystic Carcinoma

CREBBP KMT2C

1.01e-03100142C0010606
DiseaseIntellectual Disability

TANC2 MN1 KMT2C

1.11e-03447143C3714756
DiseaseAcute Myeloid Leukemia, M1

MN1 KMT2C

1.57e-03125142C0026998
DiseaseAcute Myeloid Leukemia (AML-M2)

MN1 KMT2C

1.57e-03125142C1879321
Diseaseskin pigmentation measurement

NCOA6 MYEF2

1.88e-03137142EFO_0007009
Diseaselung non-small cell carcinoma (is_implicated_in)

KMT2C KMT2D

1.93e-03139142DOID:3908 (is_implicated_in)
Diseasebreast cancer (is_implicated_in)

KAT6B NCOA6

2.24e-03150142DOID:1612 (is_implicated_in)
DiseaseProstatic Neoplasms

CREBBP KMT2C KMT2D

2.78e-03616143C0033578
DiseaseMalignant neoplasm of prostate

CREBBP KMT2C KMT2D

2.78e-03616143C0376358

Protein segments in the cluster

PeptideGeneStartEntry
APGNMQPPIRLQPLP

ERICH3

156

Q5RHP9
QPQPPVQPMQPLLPQ

AMELY

156

Q99218
LPQQQPMPGLPRPVI

CREBBP

2026

Q92793
PPPMNLPPPLLQRNM

KAT6B

1886

Q8WYB5
DPMRRPPQGLPNQLP

KMT2C

2606

Q8NEZ4
PQPQLQPPPSPQQMP

KMT2B

756

Q9UMN6
LFPPQINIPLPPRPN

NCOA6

1251

Q14686
LQPQLPPPLQPRAVP

HOXA4

136

Q00056
APQPPQAPQPLQPRK

PPHLN1

376

Q8NEY8
PLMQPPQQAPPPPQQ

MN1

336

Q10571
MNLPPSILNNPNIPP

MYEF2

206

Q9P2K5
ECRQMQQPQQPPPPP

TANC2

1371

Q9HCD6
MQLPPPRLQPPPLQQ

TOX4

436

O94842
PRLQPPPLQQMPQPP

TOX4

441

O94842
RQPGLPQPLMPTQPP

KMT2D

3321

O14686