Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	IgG receptor activity	FCGR2C FCGR2B	9.01e-05	7	42	2	GO:0019770
GeneOntologyMolecularFunction	IgG binding	FCGR2C FCGR2B	2.35e-04	11	42	2	GO:0019864
GeneOntologyMolecularFunction	immunoglobulin receptor activity	FCGR2C FCGR2B	3.87e-04	14	42	2	GO:0019763
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	RXFP4 FCGR2C GRIN2B OR10A2 GPR88 OPN1SW FCGR2B OR2T7 PKD1 OR10A5	3.93e-04	1353	42	10	GO:0004888
GeneOntologyMolecularFunction	G protein-coupled photoreceptor activity	GPR88 OPN1SW	4.46e-04	15	42	2	GO:0008020
GeneOntologyMolecularFunction	mannosidase activity	MAN2B2 MANBA	5.09e-04	16	42	2	GO:0015923
GeneOntologyMolecularFunction	photoreceptor activity	GPR88 OPN1SW	5.76e-04	17	42	2	GO:0009881
GeneOntologyMolecularFunction	phosphate transmembrane transporter activity	SLC20A2 XPR1	1.16e-03	24	42	2	GO:0005315
GeneOntologyMolecularFunction	immunoglobulin binding	FCGR2C FCGR2B	2.60e-03	36	42	2	GO:0019865
Domain	EGF_extracell	RELN DLL3	6.62e-03	60	38	2	IPR013111
Domain	EGF_2	RELN DLL3	6.62e-03	60	38	2	PF07974
Pubmed	Astrocytes modulate brain phosphate homeostasis via polarized distribution of phosphate uptake transporter PiT2 and exporter XPR1.	SLC20A2 XPR1	1.49e-06	2	43	2	39019040
Pubmed	Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium.	FCGR2C FCGR2B	1.49e-06	2	43	2	2531080
Pubmed	Expression of functional CD32 molecules on human NK cells is determined by an allelic polymorphism of the FcgammaRIIC gene.	FCGR2C FCGR2B	1.49e-06	2	43	2	9516136
Pubmed	Interplay between primary familial brain calcification-associated SLC20A2 and XPR1 phosphate transporters requires inositol polyphosphates for control of cellular phosphate homeostasis.	SLC20A2 XPR1	1.49e-06	2	43	2	32393577
Pubmed	Tubby family proteins are adapters for ciliary trafficking of integral membrane proteins.	CD8A GPR88 PKD1	3.97e-06	25	43	3	28154160
Pubmed	Genomic pathology of SLE-associated copy-number variation at the FCGR2C/FCGR3B/FCGR2B locus.	FCGR2C FCGR2B	4.48e-06	3	43	2	23261299
Pubmed	Functional Fcgamma receptor polymorphisms are associated with human allergy.	FCGR2C FCGR2B	4.48e-06	3	43	2	24586589
Pubmed	Nonallelic homologous recombination of the FCGR2/3 locus results in copy number variation and novel chimeric FCGR2 genes with aberrant functional expression.	FCGR2C FCGR2B	4.48e-06	3	43	2	26133275
Pubmed	Lysosomal Proteome and Secretome Analysis Identifies Missorted Enzymes and Their Nondegraded Substrates in Mucolipidosis III Mouse Cells.	MAN2B2 MANBA	8.94e-06	4	43	2	29773673
Pubmed	Primary Familial Brain Calcification	SLC20A2 XPR1	8.94e-06	4	43	2	20301594
Pubmed	Reelin signaling facilitates maturation of CA1 glutamatergic synapses.	RELN GRIN2B	1.49e-05	5	43	2	17229826
Pubmed	A contextual model for axonal sorting into glomeruli in the mouse olfactory system.	OR10A2 OR10A5	1.49e-05	5	43	2	15186781
Pubmed	Modified N-methyl-D-aspartate receptor subunit expression emerges in reeler Purkinje cells after accomplishment of the adult wild-type expression.	RELN GRIN2B	1.49e-05	5	43	2	9004271
Pubmed	SNPs of Fc-gamma receptor genes and chronic periodontitis.	FCGR2C FCGR2B	1.49e-05	5	43	2	20439936
Pubmed	Copy number, linkage disequilibrium and disease association in the FCGR locus.	FCGR2C FCGR2B	1.49e-05	5	43	2	20508037
Pubmed	Polyploid Hepatocytes Facilitate Adaptation and Regeneration to Chronic Liver Injury.	E2F7 HGD	1.49e-05	5	43	2	30928253
Pubmed	Copy number variation at the FCGR locus includes FCGR3A, FCGR2C and FCGR3B but not FCGR2A and FCGR2B.	FCGR2C FCGR2B	1.49e-05	5	43	2	19309690
Pubmed	Reelin deficiency causes specific defects in the molecular composition of the synapses in the adult brain.	RELN GRIN2B	3.12e-05	7	43	2	21664258
Pubmed	NMDA-receptor proteins are upregulated in the hippocampus of postnatal heterozygous reeler mice.	RELN GRIN2B	3.12e-05	7	43	2	16438943
Pubmed	Mechanism of KMT5B haploinsufficiency in neurodevelopment in humans and mice.	RELN GRIN2B	3.12e-05	7	43	2	36897941
Pubmed	Genomic analysis of orthologous mouse and human olfactory receptor loci.	OR10A2 OR10A5	5.35e-05	9	43	2	11416212
Pubmed	Expression of Phosphate Transporters during Dental Mineralization.	SLC20A2 XPR1	5.35e-05	9	43	2	28892649
Pubmed	Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface.	MAN2B2 MANBA	1.55e-04	15	43	2	8892864
Pubmed	Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells.	MAN2B2 MANBA	2.01e-04	17	43	2	2355006
Pubmed	Lymph sacs are not required for the initiation of lymph node formation.	CD8A FCGR2B	2.52e-04	19	43	2	19060331
Pubmed	Glycosylation inhibitors and neuraminidase enhance human immunodeficiency virus type 1 binding and neutralization by mannose-binding lectin.	MAN2B2 MANBA	2.80e-04	20	43	2	12560567
Pubmed	The N-Myc-DLL3 cascade is suppressed by the ubiquitin ligase Huwe1 to inhibit proliferation and promote neurogenesis in the developing brain.	RELN DLL3	3.09e-04	21	43	2	19686682
Pubmed	Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response.	MAN2B2 MANBA	3.40e-04	22	43	2	8673525
Pubmed	Effect of various glycosidase treatments on the resistance of the HIV-1 envelope to degradation.	MAN2B2 MANBA	3.40e-04	22	43	2	9109416
Pubmed	Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum.	MAN2B2 MANBA	3.40e-04	22	43	2	11530211
Pubmed	Role of asparagine-linked glycosylation in human immunodeficiency virus type 1 transmembrane envelope function.	MAN2B2 MANBA	3.72e-04	23	43	2	1736542
Pubmed	Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain.	MAN2B2 MANBA	3.72e-04	23	43	2	8093218
Pubmed	Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins.	MAN2B2 MANBA	3.72e-04	23	43	2	3099781
Pubmed	Pyramidal neurons form active, transient, multilayered circuits perturbed by autism-associated mutations at the inception of neocortex.	RELN GRIN2B	3.72e-04	23	43	2	37071993
Pubmed	Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1.	MAN2B2 MANBA	3.72e-04	23	43	2	3264072
Pubmed	TSHZ1-dependent gene regulation is essential for olfactory bulb development and olfaction.	RELN HAP1	4.05e-04	24	43	2	24487590
Pubmed	Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins.	MAN2B2 MANBA	4.40e-04	25	43	2	2283726
Pubmed	Dbx1 controls the development of astrocytes of the intermediate spinal cord by modulating Notch signaling.	RELN DLL3	4.40e-04	25	43	2	35815610
Pubmed	Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system.	MAN2B2 MANBA	4.76e-04	26	43	2	8218172
Pubmed	Effects of Pparγ1 deletion on late-stage murine embryogenesis and cells that undergo endocycle.	E2F7 CEACAM21	5.93e-04	29	43	2	34246625
Pubmed	Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1.	MAN2B2 MANBA	9.67e-04	37	43	2	2541446
Pubmed	Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport.	MAN2B2 MANBA	9.67e-04	37	43	2	2542563
Pubmed	Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis.	MAN2B2 MANBA	1.02e-03	38	43	2	2829950
Pubmed	Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1.	MAN2B2 MANBA	1.02e-03	38	43	2	2187500
GeneFamily	Olfactory receptors, family 10	OR10A2 OR10A5	4.03e-03	66	26	2	157
GeneFamily	ADAM metallopeptidase domain containing\|CD molecules	FCGR2C CD8A FCGR2B	1.84e-02	394	26	3	471
GeneFamily	Solute carriers	SLC17A9 SLC20A2 SLC23A3	1.85e-02	395	26	3	752
GeneFamily	Adenosine receptors\|V-set domain containing	CD8A CEACAM21	2.28e-02	163	26	2	590
GeneFamily	Immunoglobulin like domain containing	CEACAM21 FCGR2B	3.11e-02	193	26	2	594
Drug	PbTx-2	GRIN2B TECTA OPN1SW	1.47e-05	26	42	3	CID000002432
Drug	mannonolactam amidrazone	MAN2B2 MANBA	1.99e-05	4	42	2	CID000126858
Drug	gamma-aminobutyric acid	PORCN FCGR2C RELN GRIN2B FCGR2B HAP1 PKD1	2.33e-05	474	42	7	CID000000119
Drug	Chloropyramine hydrochloride [6170-42-9]; Up 200; 12.2uM; HL60; HT_HG-U133A	FSD1 CEACAM21 HAP1 POLM POFUT2	3.02e-05	197	42	5	3011_UP
Drug	C0107	PORCN HGD CA10	3.06e-05	33	42	3	CID000018639
Drug	MDL 20,610	FCGR2C FCGR2B	3.31e-05	5	42	2	CID000128209
Drug	TAN-1030A	FCGR2C FCGR2B	4.96e-05	6	42	2	CID009576886
Drug	5-amino-5-deoxy-D-mannopyranose	MAN2B2 MANBA	4.96e-05	6	42	2	CID000124624
Drug	Sulpiride	RELN FCGR2B SRD5A2	5.50e-05	40	42	3	ctd:D013469
Drug	AC1NS1CY	FCGR2C FSD1 FCGR2B	5.50e-05	40	42	3	CID005326941
Drug	S-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] (2R)-2-[4-(2-methylpropyl)phenyl]propanethioate	FCGR2C CD8A FCGR2B	5.93e-05	41	42	3	CID009854504
Drug	Plantagoside	MAN2B2 MANBA	6.94e-05	7	42	2	CID000174157
Drug	TAN-999	FCGR2C FCGR2B	6.94e-05	7	42	2	CID000130283
Drug	AC1MHTIN	FCGR2C FCGR2B	6.94e-05	7	42	2	CID003011133
Drug	dibenzo-p-dioxin	HGD TECTA CA10	8.94e-05	47	42	3	CID000009216
Drug	Intravenous Immunoglobulin	FCGR2C FCGR2B	9.24e-05	8	42	2	DB00028
Drug	diphenyl	HGD GRIN2B CA10 SRD5A2	1.02e-04	132	42	4	CID000007095
Drug	AC1NSK5W	FCGR2C FCGR2B	1.19e-04	9	42	2	CID005311182
Drug	GDP-Man	GRIN2B MAN2B2 MANBA POFUT2	1.28e-04	140	42	4	CID000000732
Drug	Palivizumab	FCGR2C FCGR2B	1.48e-04	10	42	2	DB00110
Drug	Denny-Jaffe reagent	FCGR2C FCGR2B	1.48e-04	10	42	2	CID003035979
Drug	NSC624746	PORCN GRIN2B TECTA	1.59e-04	57	42	3	CID000107640
Drug	tert-butyl acetate	FSD1 CD8A CA10	1.68e-04	58	42	3	CID000010908
Drug	Bevacizumab	FCGR2C FCGR2B	1.81e-04	11	42	2	DB00112
Drug	Tositumomab	FCGR2C FCGR2B	1.81e-04	11	42	2	DB00081
Drug	Alemtuzumab	FCGR2C FCGR2B	1.81e-04	11	42	2	DB00087
Drug	Efalizumab	FCGR2C FCGR2B	1.81e-04	11	42	2	DB00095
Drug	Alefacept	FCGR2C FCGR2B	1.81e-04	11	42	2	DB00092
Drug	tdaC	CD8A DLL3	2.17e-04	12	42	2	CID000008098
Drug	Daclizumab	FCGR2C FCGR2B	2.17e-04	12	42	2	DB00111
Drug	Natalizumab	FCGR2C FCGR2B	2.17e-04	12	42	2	DB00108
Drug	Rituximab	FCGR2C FCGR2B	2.17e-04	12	42	2	DB00073
Drug	Ibritumomab	FCGR2C FCGR2B	2.17e-04	12	42	2	DB00078
Drug	Adalimumab	FCGR2C FCGR2B	2.17e-04	12	42	2	DB00051
Drug	Gemtuzumab ozogamicin	FCGR2C FCGR2B	2.17e-04	12	42	2	DB00056
Drug	Cetuximab	FCGR2C FCGR2B	2.17e-04	12	42	2	DB00002
Drug	mannolipid	MAN2B2 XPR1	2.56e-04	13	42	2	CID006434507
Drug	Trastuzumab	FCGR2C FCGR2B	2.56e-04	13	42	2	DB00072
Drug	Basiliximab	FCGR2C FCGR2B	2.56e-04	13	42	2	DB00074
Drug	mannostatin A	MAN2B2 MANBA	2.56e-04	13	42	2	CID000124189
Drug	Abciximab	FCGR2C FCGR2B	2.98e-04	14	42	2	DB00054
Drug	Etanercept	FCGR2C FCGR2B	2.98e-04	14	42	2	DB00005
Drug	Muromonab	FCGR2C FCGR2B	3.44e-04	15	42	2	DB00075
Drug	H-Na	FCGR2C OPN1SW FCGR2B	3.45e-04	74	42	3	CID004369271
Drug	AC1L9IGO	E2F7 FCGR2C FCGR2B XPR1	3.64e-04	184	42	4	CID000445722
Drug	AC1MQSA8	FCGR2C CD8A FCGR2B	3.74e-04	76	42	3	CID003481670
Drug	AC1L9LSE	FCGR2C FCGR2B	3.92e-04	16	42	2	CID000448272
Drug	Nuclear Yellow	PORCN TECTA	3.92e-04	16	42	2	CID000123837
Drug	Ret-P-Man	MAN2B2 MANBA	3.92e-04	16	42	2	CID006438377
Disease	Fahr's syndrome (disorder)	SLC20A2 XPR1	1.97e-05	5	42	2	C0393590
Disease	basal ganglia calcification (is_implicated_in)	SLC20A2 XPR1	2.96e-05	6	42	2	DOID:0060230 (is_implicated_in)
Disease	plexin-B2 measurement	FCGR2C FCGR2B	7.08e-05	9	42	2	EFO_0021867
Disease	malaria (implicated_via_orthology)	FCGR2C FCGR2B	7.08e-05	9	42	2	DOID:12365 (implicated_via_orthology)
Disease	Lenticulostriate Disorders	SLC20A2 XPR1	1.29e-04	12	42	2	C0750951
Disease	Basal Ganglia Diseases	SLC20A2 XPR1	1.29e-04	12	42	2	C0004782
Disease	Extrapyramidal Disorders	SLC20A2 XPR1	1.29e-04	12	42	2	C0015371
Disease	low affinity immunoglobulin gamma Fc region receptor II-a measurement	FCGR2C FCGR2B	2.65e-04	17	42	2	EFO_0021969
Disease	temporal lobe epilepsy (is_marker_for)	RELN GRIN2B	3.70e-04	20	42	2	DOID:3328 (is_marker_for)
Disease	Huntington's disease (is_implicated_in)	GRIN2B HAP1	4.91e-04	23	42	2	DOID:12858 (is_implicated_in)
Disease	low affinity immunoglobulin gamma Fc region receptor II-b measurement	FCGR2C FCGR2B	5.81e-04	25	42	2	EFO_0021970
Disease	systemic lupus erythematosus	TMEM86B FCGR2C MANBA PCNX3 OPN1SW FCGR2B	8.84e-04	799	42	6	MONDO_0007915
Disease	Microcalcification	SLC20A2 XPR1	1.64e-03	42	42	2	C0521174
Disease	Calcinosis	SLC20A2 XPR1	1.64e-03	42	42	2	C0006663

Protein segments in the cluster

Peptide	Gene	Start	Entry
PTTAWLFIASAPFEV	CEACAM21	31	Q3KPI0
WTAVLFLAPVAGTPA	FCGR2B	31	P31994
WLFQPRGAAASPTFL	CD8A	56	P01732
PFRDAWPGTFSFIIE	DLL3	111	Q9NYJ7
IPRGAPFLTWSPASF	CCDC163	111	A0A0D9SF12
VAPVSQFPFALLGWT	POLM	421	Q9NP87
ATQAPLPGTAADFWL	PTPN23	1261	Q9H3S7
ASGFSLPVPWGVQAA	GPR88	306	Q9GZN0
FTQPLLPAFTVWCGS	FSD1	451	Q9BTV5
FVALPASGWLTTGAP	GINM1	16	Q9NU53
WTAVLFLAPVAGTPA	FCGR2C	31	P31995
WGSAFHAFAQPFAVP	PCNX3	1256	Q9H6A9
FWVCSATPVSPGFFA	OR2T7	6	P0C7T2
LFSHWAGPFSIMFTP	FRYL	1076	O94915
VPAAATIWAPFERAA	MEX3D	466	Q86XN8
PVDTGNWLFFPGATV	RELN	366	P78509
LAAASWFPGFPVATV	OR10A2	131	Q9H208
FVGTIVFGPWISFHS	PORCN	161	Q9H237
PAFKWIGPVDFSSSD	E2F7	361	Q96AV8
DAPWTRFVFQGPFGS	HAP1	101	P54257
PFVWLDVGSIPGRFS	MANBA	826	O00462
FSWHVDPFGASATTP	MAN2B2	146	Q9Y2E5
FADSDIVPPASTWVF	EEF1G	101	P26641
GSFVPVPSFWGLVNS	CA10	41	Q9NS85
WFVTVPVAGLFSAAV	SLC20A2	626	Q08357
DFPAEWIPATFARAA	MFSD5	161	Q6N075
VGASFPPGVSVAWLL	PKD1	3576	P98161
AAASWFPGFPVATVQ	OR10A5	146	Q9H207
FPGFPVATVQTTWLF	OR10A5	151	Q9H207
AIADFVIFPPRWGVA	HGD	311	Q93099
ATWTIGIGVSIPPFF	OPN1SW	156	P03999
WAAAALVTVPTAVFG	RXFP4	166	Q8TDU9
WVSPDFDTAAGSLFP	RHNO1	56	Q9BSD3
FVFLLLGAVSWPPAS	POFUT2	6	Q9Y2G5
VPWLVAIPASLFSGF	SLC17A9	281	Q9BYT1
VFPFGQAAWDPTGHS	NPAP1	1051	Q9NZP6
FREAPVLFSTGWSPL	SLC23A3	471	Q6PIS1
SFPLTDGRAFVAPFW	TECTA	86	O75443
AQPAPAWTTFRVGLF	XPR1	226	Q9UBH6
VFPAASGNFLPPSWR	XRN2	601	Q9H0D6
AAWFLQELPSFAVPA	SRD5A2	51	P31213
LIWPAAFVPGMAAFA	TMEM86B	91	Q8N661
PAAFSPFIWVQVFAE	nan	131	A1L4Q6
AGTTTRGVPDWFPFL	TCTN2	221	Q96GX1
SPSAFLEPFSADVWV	GRIN2B	546	Q13224