Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionlow-density lipoprotein particle receptor activity

LRP1B LDLR LRP8

2.97e-0616363GO:0005041
GeneOntologyMolecularFunctionlipoprotein particle receptor activity

LRP1B LDLR LRP8

7.00e-0621363GO:0030228
GeneOntologyMolecularFunctionvery-low-density lipoprotein particle receptor activity

LDLR LRP8

1.89e-054362GO:0030229
GeneOntologyMolecularFunctioncargo receptor activity

LRP1B LDLR LRP8

4.80e-0485363GO:0038024
DomainLDLR_class-A_CS

LRP1B LDLR ST14 LRP8

9.00e-0740354IPR023415
DomainLdl_recept_a

LRP1B LDLR ST14 LRP8

1.46e-0645354PF00057
Domain-

LRP1B LDLR ST14 LRP8

1.59e-06463544.10.400.10
DomainLDLRA_1

LRP1B LDLR ST14 LRP8

1.90e-0648354PS01209
DomainLDrepeatLR_classA_rpt

LRP1B LDLR ST14 LRP8

2.06e-0649354IPR002172
DomainLDLa

LRP1B LDLR ST14 LRP8

2.06e-0649354SM00192
DomainLDLRA_2

LRP1B LDLR ST14 LRP8

2.06e-0649354PS50068
DomainLdl_recept_b

LRP1B LDLR LRP8

2.16e-0614353PF00058
DomainLDLRB

LRP1B LDLR LRP8

2.16e-0614353PS51120
DomainLY

LRP1B LDLR LRP8

2.70e-0615353SM00135
DomainLDLR_classB_rpt

LRP1B LDLR LRP8

2.70e-0615353IPR000033
Domain-

LRP1B LDLR LRP8

5.26e-05393532.120.10.30
Domain6-blade_b-propeller_TolB-like

LRP1B LDLR LRP8

8.66e-0546353IPR011042
DomainIG_FLMN

FLNA FLNC

1.52e-0410352SM00557
DomainFilamin

FLNA FLNC

1.86e-0411352PF00630
DomainFilamin/ABP280_rpt

FLNA FLNC

1.86e-0411352IPR001298
DomainFilamin/ABP280_repeat-like

FLNA FLNC

1.86e-0411352IPR017868
DomainFILAMIN_REPEAT

FLNA FLNC

1.86e-0411352PS50194
DomainZinc_finger_PHD-type_CS

PHF20L1 PHF3 CHD5

2.43e-0465353IPR019786
DomainEGF_CA

LRP1B LDLR LRP8

5.55e-0486353PF07645
DomainZF_PHD_1

PHF20L1 PHF3 CHD5

7.64e-0496353PS01359
DomainEGF_Ca-bd_CS

LRP1B LDLR LRP8

7.88e-0497353IPR018097
DomainEGF_CA

LRP1B LDLR LRP8

8.36e-0499353PS01187
DomainActinin_actin-bd_CS

FLNA FLNC

8.42e-0423352IPR001589
DomainACTININ_2

FLNA FLNC

8.42e-0423352PS00020
DomainACTININ_1

FLNA FLNC

8.42e-0423352PS00019
DomainASX_HYDROXYL

LRP1B LDLR LRP8

8.61e-04100353PS00010
DomainEGF-type_Asp/Asn_hydroxyl_site

LRP1B LDLR LRP8

1.02e-03106353IPR000152
DomainEGF_CA

LRP1B LDLR LRP8

1.53e-03122353SM00179
DomainEGF-like_Ca-bd_dom

LRP1B LDLR LRP8

1.60e-03124353IPR001881
DomainZnf_FYVE_PHD

PHF20L1 PHF3 CHD5

2.60e-03147353IPR011011
DomainGrowth_fac_rcpt_

LRP1B LDLR LRP8

3.08e-03156353IPR009030
DomainCH

FLNA FLNC

6.59e-0365352SM00033
DomainCH

FLNA FLNC

7.61e-0370352PF00307
Domain-

FLNA FLNC

7.82e-03713521.10.418.10
DomainCH

FLNA FLNC

8.25e-0373352PS50021
DomainPHD

PHF3 CHD5

8.69e-0375352PF00628
DomainCH-domain

FLNA FLNC

8.69e-0375352IPR001715
DomainEGF_3

LRP1B LDLR LRP8

9.57e-03235353PS50026
DomainEGF

LRP1B LDLR LRP8

9.57e-03235353SM00181
DomainZnf_PHD-finger

PHF3 CHD5

9.60e-0379352IPR019787
DomainEGF-like_dom

LRP1B LDLR LRP8

1.12e-02249353IPR000742
PathwayWP_NPHP1_DELETION_SYNDROME

FLNA FLNC

1.15e-0411212M48099
PathwayREACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS

FLNA FLNC

3.19e-0418212MM15123
PathwayREACTOME_CELL_EXTRACELLULAR_MATRIX_INTERACTIONS

FLNA FLNC

3.19e-0418212M840
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

RSBN1 GPATCH4 CEP295 CLSPN SIPA1L2 LDLR ANKRD54 CHD5 BRD9 SCAPER

1.32e-071116361031753913
Pubmed

Mapping of two genes encoding isoforms of the actin binding protein ABP-280, a dystrophin like protein, to Xq28 and to chromosome 7.

FLNA FLNC

1.04e-0623627689010
Pubmed

A new low density lipoprotein receptor homologue with 8 ligand binding repeats in brain of chicken and mouse.

LDLR LRP8

1.04e-0623628662771
Pubmed

Filamin isogene expression during mouse myogenesis.

FLNA FLNC

1.04e-06236210679933
Pubmed

A novel structural unit in the N-terminal region of filamins.

FLNA FLNC

1.04e-06236224469451
Pubmed

MESD is essential for apical localization of megalin/LRP2 in the visceral endoderm.

LRP1B LDLR LRP8

1.34e-062136321337463
Pubmed

Filamins as integrators of cell mechanics and signalling.

FLNA FLNC

3.12e-06336211252955
Pubmed

The F-actin cross-linking and focal adhesion protein filamin A is a ligand and in vivo substrate for protein kinase C alpha.

FLNA FLNC

3.12e-06336212704190
Pubmed

Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain.

LDLR LRP8

3.12e-0633628626535
Pubmed

Mode of interaction between beta2GPI and lipoprotein receptors suggests mutually exclusive binding of beta2GPI to the receptors and anionic phospholipids.

LDLR LRP8

3.12e-06336220223219
Pubmed

Indications for a novel muscular dystrophy pathway. gamma-filamin, the muscle-specific filamin isoform, interacts with myotilin.

FLNA FLNC

3.12e-06336211038172
Pubmed

Localization and enhanced current density of the Kv4.2 potassium channel by interaction with the actin-binding protein filamin.

FLNA FLNC

3.12e-06336211102480
Pubmed

Filamin A negatively regulates the transcriptional activity of p73alpha in the cytoplasm.

FLNA FLNC

3.12e-06336217825253
Pubmed

Filamin A and Filamin B are co-expressed within neurons during periods of neuronal migration and can physically interact.

FLNA FLNC

3.12e-06336212393796
Pubmed

Differential functions of ApoER2 and very low density lipoprotein receptor in Reelin signaling depend on differential sorting of the receptors.

LDLR LRP8

3.12e-06336219948739
Pubmed

Cytoskeletal protein ABP-280 directs the intracellular trafficking of furin and modulates proprotein processing in the endocytic pathway.

FLNA FLNC

3.12e-0633629412467
Pubmed

Genomic structure and fine mapping of the two human filamin gene paralogues FLNB and FLNC and comparative analysis of the filamin gene family.

FLNA FLNC

3.12e-06336211153914
Pubmed

The P2Y2 receptor mediates uptake of matrix-retained and aggregated low density lipoprotein in primary vascular smooth muscle cells.

FLNA LDLR

6.24e-06436227522265
Pubmed

The sarcomeric Z-disc component myopodin is a multiadapter protein that interacts with filamin and alpha-actinin.

FLNA FLNC

6.24e-06436220554076
Pubmed

The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin.

FLNA FLNC

6.24e-06436211739414
Pubmed

Structural interaction and functional regulation of polycystin-2 by filamin.

FLNA FLNC

6.24e-06436222802962
Pubmed

Reelin is a ligand for lipoprotein receptors.

LDLR LRP8

6.24e-06436210571240
Pubmed

FERM-dependent E3 ligase recognition is a conserved mechanism for targeted degradation of lipoprotein receptors.

LDLR LRP8

6.24e-06436222109552
Pubmed

A Degradation Motif in STAU1 Defines a Novel Family of Proteins Involved in Inflammation.

FLNA FLNC GPATCH4 PUM1 PHF3 ICE2 BRD9

8.12e-0672436736232890
Pubmed

PCSK9 binds to multiple receptors and can be functionally inhibited by an EGF-A peptide.

LDLR LRP8

1.04e-05536218675252
Pubmed

HIV infection of T cells: actin-in and actin-out.

FLNA FLNC

1.04e-05536219366992
Pubmed

Nephrocystin-conserved domains involved in targeting to epithelial cell-cell junctions, interaction with filamins, and establishing cell polarity.

FLNA FLNC

1.04e-05536212006559
Pubmed

Filamin B deficiency in mice results in skeletal malformations and impaired microvascular development.

FLNA FLNC

1.04e-05536217360453
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

FLNA FLNC SCN11A CEP295 SIPA1L2 PHF20L1 USP1 ADAM7 CHD5

1.21e-05144236935575683
Pubmed

A dual-activity topoisomerase complex regulates mRNA translation and turnover.

FLNA FLNC SIPA1L2 PUM1 LDLR ST14 CHD5 C6orf132

1.39e-05110536835748872
Pubmed

PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain.

LDLR LRP8

1.56e-05636220453200
Pubmed

Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells.

FLNA FLNC

1.56e-0563629006895
Pubmed

Migfilin and Mig-2 link focal adhesions to filamin and the actin cytoskeleton and function in cell shape modulation.

FLNA FLNC

1.56e-05636212679033
Pubmed

HSPB7 interacts with dimerized FLNC and its absence results in progressive myopathy in skeletal muscles.

FLNA FLNC

2.18e-05736226929074
Pubmed

The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins.

FLNA FLNC

2.18e-05736216076904
Pubmed

The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor.

LDLR LRP8

2.18e-05736212169628
Pubmed

The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3.

USP1 CHD5 BRD9

2.87e-055736321555454
Pubmed

MEKK4 signaling regulates filamin expression and neuronal migration.

FLNA FLNC

2.91e-05836217145501
Pubmed

HSPB7 prevents cardiac conduction system defect through maintaining intercalated disc integrity.

FLNA FLNC

2.91e-05836228827800
Pubmed

Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2.

LDLR LRP8

2.91e-05836210380922
Pubmed

Comparative mapping of the actin-binding protein 280 genes in human and mouse.

FLNA FLNC

3.73e-0593628088838
Pubmed

Overexpression of low-density lipoprotein receptor in the brain markedly inhibits amyloid deposition and increases extracellular A beta clearance.

LDLR LRP8

3.73e-05936220005821
Pubmed

Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits.

FLNA FLNC

3.73e-05936211807098
Pubmed

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.

FLNA GPATCH4 GRIK2 CLSPN USP1 LDLR ICE2 SCAPER

5.13e-05132736832694731
Pubmed

Mouse endothelial OTUD1 promotes angiotensin II-induced vascular remodeling by deubiquitinating SMAD3.

FLNA FLNC

5.70e-051136236579465
Pubmed

Stage-specific association of apolipoprotein A-I and E in developing mouse retina.

LDLR LRP8

9.41e-051436217389516
Pubmed

A systems-wide screen identifies substrates of the SCFβTrCP ubiquitin ligase.

FLNC CLSPN SIPA1L2 PUM1

9.61e-0523236425515538
Pubmed

An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.

CEP295 CLSPN PUM1 USP1 PHF3 ICE2

9.75e-0573336634672954
Pubmed

Organization of focal adhesion plaques is disrupted by action of the HIV-1 protease.

FLNA FLNC

1.58e-041836212119179
Pubmed

Interactions of the low density lipoprotein receptor gene family with cytosolic adaptor and scaffold proteins suggest diverse biological functions in cellular communication and signal transduction.

LDLR LRP8

1.58e-041836210827173
Pubmed

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins.

LRP1B LDLR LRP8

1.58e-0410136323382219
Pubmed

Asb2α-Filamin A Axis Is Essential for Actin Cytoskeleton Remodeling During Heart Development.

FLNA FLNC

1.76e-041936229374072
Pubmed

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1.

FSTL4 GRIK2 HNRNPUL2 LRP1B LDLR LRP8 SCAPER

2.00e-04120136735696571
Pubmed

Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.

NPAS3 FLNC PHF20L1 PUM1 HNRNPUL2 MEF2C

2.28e-0485736625609649
Pubmed

A central chaperone-like role for 14-3-3 proteins in human cells.

STAM2 SIPA1L2 PUM1 PHF3 KIAA1217 C6orf132

2.34e-0486136636931259
Pubmed

Fine expression profiling of full-length transcripts using a size-unbiased cDNA library prepared with the vector-capping method.

FLNA FLNC

2.38e-042236218487259
Pubmed

Chromosomal localization of glutamate receptor genes: relationship to familial amyotrophic lateral sclerosis and other neurological disorders of mice and humans.

GRIK2 LDLR

2.60e-04233628464923
Pubmed

DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169.

FLNC SIPA1L2 ICE2

2.76e-0412236330773093
Pubmed

Functional proteomics mapping of a human signaling pathway.

SPRED1 FLNA STAM2 FLNC PUM1

3.40e-0459136515231748
Pubmed

The in vivo Interaction Landscape of Histones H3.1 and H3.3.

GPATCH4 PHF20L1 PHF3 CHD5 BRD9

3.87e-0460836536089195
Pubmed

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

RSBN1 FLNA GPATCH4 PUM1 PHF3 BRD9

4.04e-0495436636373674
Pubmed

The PRMT5/WDR77 complex regulates alternative splicing through ZNF326 in breast cancer.

FLNC HNRNPUL2 CHD5

4.77e-0414736328977470
Pubmed

Gene-smoking interactions identify several novel blood pressure loci in the Framingham Heart Study.

SIPA1L2 LRP1B

5.07e-043236225189868
Pubmed

The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function.

CHD5 LRP8

5.39e-043336222357600
Pubmed

The CARM1-p300-c-Myc-Max (CPCM) transcriptional complex regulates the expression of CUL4A/4B and affects the stability of CRL4 E3 ligases in colorectal cancer.

USP1 MEF2C

5.39e-043336232140074
Pubmed

SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.

RSBN1 FLNA GPATCH4 PUM1 HNRNPUL2

5.43e-0465536535819319
Pubmed

Human transcription factor protein interaction networks.

RSBN1 GPATCH4 PUM1 HNRNPUL2 MEF2C CHD5 BRD9

5.71e-04142936735140242
Pubmed

USP1 deubiquitinates Akt to inhibit PI3K-Akt-FoxO signaling in muscle during prolonged starvation.

USP1 KIAA1217

6.78e-043736232133736
Pubmed

Pro-prion, as a membrane adaptor protein for E3 ligase c-Cbl, facilitates the ubiquitination of IGF-1R, promoting melanoma metastasis.

PHF3 LDLR MEF2C BRD9 SCAPER

6.82e-0468936536543142
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

RSBN1 SIPA1L2 PUM1 PHF3

8.10e-0440736412693553
Pubmed

Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells.

HNRNPUL2 PHF3 KIAA1217

8.18e-0417736326206133
Pubmed

Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2.

FLNA FLNC

8.33e-044136218157088
Pubmed

Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein.

RSBN1 FLNA FLNC GPATCH4 HNRNPUL2

8.57e-0472536527025967
Pubmed

RECQ1 helicase is involved in replication stress survival and drug resistance in multiple myeloma.

GPATCH4 HP PHF3

9.00e-0418336328186131
Pubmed

A Multipronged Unbiased Strategy Guides the Development of an Anti-EGFR/EPHA2-Bispecific Antibody for Combination Cancer Therapy.

STAM2 SIPA1L2 KIAA1217 LRP8

9.18e-0442136436976175
Pubmed

STUB1 is targeted by the SUMO-interacting motif of EBNA1 to maintain Epstein-Barr Virus latency.

FLNA FLNC HP

1.03e-0319236332176739
GeneFamilyLow density lipoprotein receptors

LRP1B LDLR LRP8

6.62e-0713253634
GeneFamilyPHD finger proteins

PHF20L1 PHF3 CHD5

2.53e-049025388
CoexpressionSHEPARD_CRASH_AND_BURN_MUTANT_DN

CEP295 PHF20L1 PUM1 PHF3 CHD5

6.12e-06191365M2148
CoexpressionSHEN_SMARCA2_TARGETS_UP

RSBN1 ANKMY2 STAM2 USP1 PHF3 SCAPER

2.39e-05429366M29
CoexpressionAtlasFacebaseRNAseq_e10.5_Lateral Nasal Eminence_top-relative-expression-ranked_500_k-means-cluster#4

CLIC5 CLSPN SIPA1L2 USP1 ICE2

1.72e-05192365Facebase_RNAseq_e10.5_Lateral Nasal Eminence_500_K4
CoexpressionAtlasfacebase_RNAseq_e10.5_Emin_LatNas_2500

RSBN1 SPRED1 GPATCH4 CEP295 GRIK2 CLIC5 CLSPN USP1 PHF3 ICE2 LRP8

1.88e-0514593611facebase_RNAseq_e10.5_Emin_LatNas_2500
CoexpressionAtlasFacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_1000

NPAS3 CEP295 GRIK2 CLIC5 CLSPN HNRNPUL2 LDLR ICE2 LRP8

3.00e-05989369Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_1000
CoexpressionAtlasFacebaseRNAseq_e10.5_Mandibular Arch_top-relative-expression-ranked_1000_k-means-cluster#3

NPAS3 CLIC5 CLSPN USP1 LRP8

8.90e-05271365Facebase_RNAseq_e10.5_Mandibular Arch_1000_K3
CoexpressionAtlasFacebaseRNAseq_e10.5_Lateral Nasal Eminence_top-relative-expression-ranked_1000_k-means-cluster#3

CLIC5 CLSPN SIPA1L2 USP1 ICE2

1.24e-04291365Facebase_RNAseq_e10.5_Lateral Nasal Eminence_1000_K3
CoexpressionAtlasfacebase_RNAseq_e10.5_Emin_LatNas_2500_K3

RSBN1 SPRED1 GPATCH4 CEP295 CLIC5 CLSPN USP1 PHF3 ICE2

1.91e-041257369facebase_RNAseq_e10.5_Emin_LatNas_2500_K3
ToppCellH1299-infected-SARSCoV2|infected / Cell line, Condition and Strain

GPATCH4 CEP295 CLSPN BRD9 SCAPER

5.16e-071973650fa3e4cf93e77d78b1f97b906c5b13ca741ae17e
ToppCellLPS_only-Endothelial-Endothelial-Alv_Gen_Intermediate|LPS_only / Treatment groups by lineage, cell group, cell type

CLIC5 RHOBTB1 SIPA1L2 MEF2C KIAA1217

5.56e-07200365b1fadb2b5e37e0f51e079d8409c2647eef68dc3b
ToppCellfacs-Brain_Non-Myeloid-Striatum-24m-Neuronal|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FSTL4 GRIK2 ADAM7 CHD5

1.29e-05179364a3922476f33d2e4137a12dbda21a1703dff79684
ToppCellControl-Endothelial_cells-Capillary_endothelial_cells|Control / group, cell type (main and fine annotations)

FSTL4 SIPA1L2 LRP1B KIAA1217

1.32e-05180364b043f9ffb9a4cd427a15bebb86a711c7b08866e8
ToppCellControl-Endothelial-Endothelial-Activated_Alv_Cap|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CLIC5 SIPA1L2 MEF2C KIAA1217

1.41e-05183364e81c142770f44fd902b0631bc360c5b5339d4c75
ToppCell3'_v3-lymph-node_spleen-Lymphocytic_Invariant-Inducer-like-ILC3|lymph-node_spleen / Manually curated celltypes from each tissue

CLIC5 RHOBTB1 TMIGD2 KIAA1217

1.44e-05184364479e60f76c191253e23699c9dd7ef7efc08c59ad
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

NPAS3 SPRED1 RHOBTB1 MEF2C

1.47e-051853648207f9eff113eed429e961748c6b17d672a13b33
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-Lgr5-_amplifying_undifferentiated_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RSBN1 FLNA CEP295 CLSPN

1.50e-0518636415ab6666748a641226e42e6ca6eeaf186a501c95
ToppCellfacs-Large_Intestine-Proximal-3m-Epithelial-epithelial_cell_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RSBN1 FLNA CEP295 CLSPN

1.50e-051863644ed1b97e2552f3c4134f25665d7513498ffac16c
ToppCellControl-Endothelial-Endothelial-Alv_Cap|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CLIC5 SIPA1L2 MEF2C KIAA1217

1.53e-05187364ea9d34bcd3bd1f36745846309ede349773de501a
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NPAS3 GRIK2 KIAA1217 LRP8

1.53e-0518736485f1678338a47d91e296f0620d4887f057eb7e70
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CLIC5 LDLR ST14 C6orf132

1.57e-0518836443a3a59f92ad93509d4166bd025aed0b1b39a008
ToppCellChildren_(3_yrs)-Immune-interstitial_macrophage_(C1Q_positive)|Children_(3_yrs) / Lineage, Cell type, age group and donor

NPAS3 SPRED1 RHOBTB1 MEF2C

1.63e-05190364f573fef3762a30c38cf8fa7f45df0ffbb49dc873
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NPAS3 GRIK2 KIAA1217 LRP8

1.70e-05192364dc40ef2341e5d6a6d479f140e023fe1bf687928d
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NPAS3 GRIK2 KIAA1217 LRP8

1.74e-05193364d1445b8bf2bab36e1a326ddb2a528151db016c7d
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NPAS3 GRIK2 KIAA1217 LRP8

1.74e-05193364010717ca052b6c8a525a43aaeffddea0d1113e63
ToppCellMid-temporal_gyrus_(MTG)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NPAS3 GRIK2 KIAA1217 LRP8

1.74e-051933642189da4b727e25e62669d7b9257f06493be21a27
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L4-6_SST_MTHFD2P6|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NPAS3 GRIK2 KIAA1217 LRP8

1.74e-051933648b77625bf3c87d39767fb391d1beaca4ab02342b
ToppCellLPS-IL1RA-Endothelial-Endothelial-Activated_Alv_Cap|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

CLIC5 RHOBTB1 SIPA1L2 KIAA1217

1.74e-05193364a3636c35ed25aabe2f1aba016c9fe125327bbfaf
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NPAS3 GRIK2 KIAA1217 LRP8

1.74e-051933643ed46f5a7419ec4eddbd0df0d9b5f53aa486198b
ToppCellSomatosensory_Cortex_(S1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NPAS3 GRIK2 KIAA1217 LRP8

1.74e-05193364e74fdc8718fe0933e1f4dd3fe37e2134983b99b6
ToppCellprimary_auditory_cortex_(A1C)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NPAS3 GRIK2 KIAA1217 LRP8

1.74e-05193364658c2b30a4d806c5ce78ea4392fe8eb86b8d1e99
ToppCellnucseq-Epithelial-Epithelial_Alveolar-Secretory/RAS|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

GRIK2 LDLR KIAA1217 C6orf132

1.77e-051943640cd4363627acd419e00d6d32f6dce10430aa6487
ToppCellnucseq-Epithelial-Epithelial_Alveolar-Secretory/RAS-RAS|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

GRIK2 LDLR KIAA1217 C6orf132

1.77e-05194364a58841b34efe673671a9a059238e044a7254b279
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Inh_GABAergic-i_Gaba_3-GABA_SST-Inh_L3-5_SST_MAFB|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NPAS3 GRIK2 KIAA1217 LRP8

1.77e-051943641bcb3fafd498614f7bac2b1c9b7de56e39110f65
ToppCelldroplet-Mammary_Gland-nan-3m-Epithelial-luminal_progenitor_cell|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

NPAS3 LDLR ST14 C6orf132

1.84e-0519636422fcfb713f402ebbd43b2822f0fd919cdbfba6e4
ToppCellCOVID-19-lung-Capillary_Aerocytes|lung / Disease (COVID-19 only), tissue and cell type

FSTL4 SIPA1L2 LRP1B KIAA1217

1.84e-051963644ac4073380d939a73cec7413e9f3f5ef616d2924
ToppCellControl_saline|World / Treatment groups by lineage, cell group, cell type

CLIC5 SIPA1L2 MEF2C KIAA1217

1.96e-0519936411c9c1779caceb725ecccf3f23b7d4e6dbd1af64
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-B3GAT2|Neuronal / cells hierarchy compared to all cells using T-Statistic

NPAS3 GRIK2 KIAA1217 LRP8

2.00e-05200364858421b91f5207b7934b5c219752cb9322a3da31
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-STK32A-|Neuronal / cells hierarchy compared to all cells using T-Statistic

NPAS3 GRIK2 KIAA1217 LRP8

2.00e-052003646a44439e4a7ce3627271375b04cfcfb9467218f4
ToppCellControl_saline-Endothelial-Endothelial-Alv_Gen_Intermediate|Control_saline / Treatment groups by lineage, cell group, cell type

CLIC5 SIPA1L2 MEF2C KIAA1217

2.00e-05200364041a34080120c9f613373c20dcc366292f558040
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-B3GAT2-|Neuronal / cells hierarchy compared to all cells using T-Statistic

NPAS3 GRIK2 KIAA1217 LRP8

2.00e-05200364a7022762c1d8aedb7b3e9605873b1e68b9907b35
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-STK32A|Neuronal / cells hierarchy compared to all cells using T-Statistic

NPAS3 GRIK2 KIAA1217 LRP8

2.00e-052003648d51b4f7b7002ee51401ebe5eaca1e8f04bfadd5
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-STK32A--L4-5|Neuronal / cells hierarchy compared to all cells using T-Statistic

NPAS3 GRIK2 KIAA1217 LRP8

2.00e-05200364cb1f4b0d66da5b0466ff17b29e7034d451d93e4f
ToppCellNeuronal-Inhibitory-iB-iB_4(SST)-B3GAT2--L4-6|Neuronal / cells hierarchy compared to all cells using T-Statistic

NPAS3 GRIK2 KIAA1217 LRP8

2.00e-052003642131c8e7fa054b79906eaf60536da892438b09cd
ToppCellChildren_(3_yrs)-Epithelial-lung_goblet_cell-D046|Children_(3_yrs) / Lineage, Cell type, age group and donor

GRIK2 LRP1B KIAA1217

2.49e-041523631b2a39ae159e79f1fb18d6d164bd7acab5299fca
ToppCell10x5'-Liver-Myeloid_Mac-Intestinal_macrophages|Liver / Manually curated celltypes from each tissue

SPRED1 LRP1B KIAA1217

2.68e-041563639a897fc79c4fae94c5f2e9012d65297f9225e5e3
ToppCellrenal_medulla_nuclei-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_distal_convoluted_tubule_epithelial_cell-Distal_Convoluted_Tubule_Cell_Type_2|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FSTL4 CLSPN LRP1B

2.79e-041583637960337d87afecf2692ab65e5991f052ceddfacc
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NPAS3 GRIK2 CLIC5

2.84e-04159363fd7db2f7328cfefdc3ada2af91006d5a91d137e1
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NPAS3 GRIK2 CLIC5

2.84e-04159363aaf449c768d6fbb0a1bb47746ff3bdb7f9eb8914
ToppCellsaliva-Severe-critical_progression_d12-22_no-steroids-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell-T_CD8_c01-LEF1|Severe-critical_progression_d12-22_no-steroids / Compartment, severity and other cell annotations on 10x 3' data (130k)

SCN11A CEP295 CLIC5

2.84e-041593632233fee5dcdb6c7dee5b1bd8efbc07d86b339927
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NPAS3 GRIK2 CLIC5

2.84e-041593638bbdef1e927f3130b578d7d7c5ff38bbe06fab63
ToppCellfacs-Brain_Myeloid-Cerebellum-24m-Myeloid-macrophage|Brain_Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation

FLNA HP LDLR

2.89e-041603631f7acdc8b08152d5817fc53bbf47b4a22d9c91b5
ToppCellLV-13._Vascular_Smooth_Muscle|World / Chamber and Cluster_Paper

FSTL4 FLNA MEF2C

3.16e-04165363f37fd95adc95d7753cf6e55ae819976513c7ec77
ToppCellPND10-Mesenchymal-Mesenchymal_myocytic-Myofibroblast_vascular-VSMC-VSMC_prolif|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

FLNA CLSPN LRP8

3.28e-04167363784776d1fcc098f84d3c2eca58fa56cb9428f434
ToppCell3'_v3-bone_marrow-Myeloid_Mac-Intermediate_macrophages|bone_marrow / Manually curated celltypes from each tissue

SPRED1 SIPA1L2 ST14

3.34e-041683638ade4d098aeecda2d80c1cad1cebe9a063eae948
ToppCellCOVID-19-Heart-Neuronal|COVID-19 / Disease (COVID-19 only), tissue and cell type

GRIK2 SIPA1L2 KIAA1217

3.34e-0416836388c2c574f428c2502b5fe099bd73b0758f668ef6
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NPAS3 GRIK2 CLIC5

3.34e-04168363fc80e4fecfc92458eb627013a983041d8ca025a9
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NPAS3 GRIK2 CLIC5

3.34e-04168363315ca578c945aeeb77acda2727f3e6db8b43f43e
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NPAS3 GRIK2 CLIC5

3.34e-04168363e96859dbf51cf8c4def8ee8db132f4d874fb4381
ToppCell3'_v3-Lung-Myeloid_Mac-Intestinal_macrophages|Lung / Manually curated celltypes from each tissue

SPRED1 RHOBTB1 MEF2C

3.39e-04169363241644823e6f949aaf4c671d4579721d7ef6b0e5
ToppCellkidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NPAS3 GRIK2 CLIC5

3.45e-0417036360bbd738c12e64e483485586c30057304884f5a6
ToppCelldroplet-Lung-1m-Hematologic-myeloid-interstitial_macrophage|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RSBN1 RHOBTB1 MEF2C

3.45e-04170363f664c7559e383b37845c123e41a3be316d869ba0
ToppCelldroplet-Lung-1m-Hematologic-myeloid-interstitial_macrophage-interstitial_macrophage_l12|1m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RSBN1 RHOBTB1 MEF2C

3.45e-041703630272eb1487c2545d4aa06f5d1cd77f823e1441e9
ToppCellControl-Epithelial_cells-Airway_basal|Control / group, cell type (main and fine annotations)

NPAS3 GRIK2 KIAA1217

3.51e-041713633965ced4be6db14265a90673502fceee425837ca
ToppCell10x3'2.3-week_12-13-Lymphocytic_NK-T_NK-NK_progenitor|week_12-13 / cell types per 3 fetal stages;per 3',per 5'

FSTL4 RSBN1 TMIGD2

3.57e-04172363a126dacd94939851de1403d30f0b63eaad48bfa1
ToppCellfacs-Large_Intestine-Distal-18m-Epithelial-epithelial_cell_of_large_intestine|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RSBN1 CLSPN LRP8

3.63e-04173363a5172dee859bf6c2eed46c48bd64dfef0ff9f28f
ToppCellfacs-Large_Intestine-Distal-18m-Epithelial-Lgr5-_amplifying_undifferentiated_cell|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RSBN1 CLSPN LRP8

3.63e-04173363639b5b0b33ce5aa0bc26363c059717012ddc14c0
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell-|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FLNA FLNC MEF2C

3.63e-04173363fc2602b2ce051cd4c33957d7e3d041ff8a529883
ToppCellPBMC-Severe-Myeloid-cDC-cDC-cDC_12|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CLSPN LRP1B MEF2C

3.63e-04173363a55f310c533432e9e26e400026a5b47245152976
ToppCellCOVID-19-Heart-Neuronal|Heart / Disease (COVID-19 only), tissue and cell type

GRIK2 SIPA1L2 KIAA1217

3.63e-041733636fb5f9e6536a5d57fd8e6657b494047a2d0bc9c7
ToppCellPBMC-Severe-Myeloid-cDC-cDC-cDC_12|Severe / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CLSPN LRP1B MEF2C

3.63e-041733639c7386bf0a899882c733f0b4921a96afde032a7d
ToppCellkidney_cells-Adult_normal_reference-Mesenchymal-Myocytic_interstitial_cell-Vascular_Smooth_Muscle_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

FLNA FLNC MEF2C

3.63e-04173363901b8e6909c1f3849906fad9cee17b8f0bab050d
ToppCell(6)_Endothelial_cells-(6)_Endothelial-E|(6)_Endothelial_cells / Lung cell shreds - cell class (v4) and cell subclass (v4)

CLIC5 MEF2C KIAA1217

3.70e-041743634a1b67ce5ea353b3f81f59fa57da07668146afca
ToppCellPND07-Endothelial-Endothelial_blood-vessel-Microvascular_EC-EPC-EPC_prolif|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

CLIC5 CLSPN USP1

3.70e-0417436366555c610251ea04f968c258e312d720c18e7cde
ToppCellPrimary_Visual_cortex_(V1C)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT2_L6_FEZF2|Primary_Visual_cortex_(V1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

ST14 KIAA1217 LRP8

3.70e-041743637d4b860e05b5931f6f9d757a68f75ff35597a47a
ToppCellClub-club-15|World / Class top

CLSPN USP1 BRD9

3.76e-04175363ca9d012f520f697c7450ec6958a015e20538a6a8
ToppCellCOVID-19-kidney-Podocyte|COVID-19 / Disease (COVID-19 only), tissue and cell type

NPAS3 GRIK2 CLIC5

3.76e-04175363a73e3a65fd5c1e09cb0c2dae20c1a7bfcae49223
ToppCellAdult-Epithelial-lung_neuroendocrine_cell_(PNEC)|Adult / Lineage, Cell type, age group and donor

FSTL4 NPAS3 GRIK2

3.76e-041753634db1a3c284488b3f6de7568363f176d74e2a4587
ToppCellAdult-Epithelial-lung_neuroendocrine_cell_(PNEC)-D231|Adult / Lineage, Cell type, age group and donor

FSTL4 NPAS3 GRIK2

3.76e-041753638d9f44a2633b71fb4d2b4a7d9530f954e07c4a18
ToppCell3'-GW_trimst-2-SmallIntestine-Neuronal-neurons_B-Branch_B3_(IPAN)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

SCN11A GRIK2 CHD5

3.82e-0417636304dad262929581872e5bbc66cd8182c963e7e52f
ToppCelldroplet-Lung-LUNG-30m-Lymphocytic-Plasma_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RHOBTB1 ST14 MEF2C

3.82e-04176363606704098bfdf8bfef740a3544a372fae1e75969
ToppCelldroplet-Lung-LUNG-30m-Lymphocytic-plasma_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

RHOBTB1 ST14 MEF2C

3.82e-04176363acb9e29773030f6452a069f8f7e53eab68ab7bd3
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_12|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)

CLSPN ST14 LRP8

3.88e-04177363cbedac0bddb8fc330a464815c905928c553b0fc0
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NPAS3 GRIK2 CLIC5

3.88e-041773634d2cdb57b427a42085c5f9affa0967b15e84dec3
ToppCellcellseq2-Mesenchymal-Fibroblastic-Fibroblastic_2-ASMC|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FLNA FLNC LRP1B

3.95e-041783638ec2a25dda96c9cc9c2904b6cb18f75a293f4969
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell-|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FLNA FLNC CHD5

3.95e-04178363c661246269ce26c4fc62e12f86c5f90a2dcfdce0
ToppCellcellseq2-Mesenchymal-Fibroblastic-Fibroblastic_2|cellseq2 / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

FLNA FLNC LRP1B

3.95e-041783636c91331196696e0cf239d105f458e3230659fa38
ToppCellrenal_cortex_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NPAS3 GRIK2 CLIC5

3.95e-04178363edc7143dc9959d36057cb9471681a23afcbc8cce
ToppCelldroplet-Bladder-BLADDER-1m-Endothelial-nan|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLIC5 CLSPN MEF2C

3.95e-041783636bef4ef48f649c6e38ae732bc08e6d7814db588b
ToppCellPBMC-Control-Myeloid-cDC-cDC-cDC_12|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)

CLSPN ST14 LRP8

3.95e-0417836304bfecf5ea5d85c843e48d08718b5d69e7bf834e
ToppCellfacs-Heart-RA-18m|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation

USP1 HNRNPUL2 LDLR

3.95e-04178363b505e2550860e777535ee95f29c936242fd607f1
ToppCellrenal_cortex_nuclei-Hypertensive_with+without-CKD-Mesenchymal-Myocytic_interstitial_cell-Degenerative_Vascular_Smooth_Muscle_Cell|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group

FLNA FLNC CHD5

3.95e-04178363e5e5f5b4a27e120a1076b1cb250fa25d0c336956
ToppCellAdult-Epithelial-club_cell-D122|Adult / Lineage, Cell type, age group and donor

GRIK2 LRP1B KIAA1217

3.95e-0417836335a2e3ba98b6f857dbb79cf8ddb4846ddcda6c17
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NPAS3 GRIK2 CLIC5

4.01e-041793637394e77e665bf16d3733df91bb12907be460ab44
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Inh_GABAergic-i_Gaba_2-GABA_VIP_1-Inh_L1_SST_CXCL14|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

NPAS3 GRIK2 SIPA1L2

4.01e-04179363c7afbd10072d36a35cd20ae73670d76b9cefd22d
ToppCellIPF-Epithelial-Mesothelial|IPF / Disease state, Lineage and Cell class

NPAS3 FLNC HP

4.08e-041803631fa54bf4dba72866b2295639d991af639341bc08
ToppCellCOVID-19-kidney-PLVAP+EC|COVID-19 / Disease (COVID-19 only), tissue and cell type

SIPA1L2 MEF2C KIAA1217

4.08e-04180363493cf8d1a8f2a1ed2672f394a0338b110fd81d88
ToppCellCV-Healthy-2|CV / Virus stimulation, Condition and Cluster

GPATCH4 LDLR BRD9

4.08e-04180363e182e5c495dd82d4fcbf1a920086c70b064801f3
ToppCelldroplet-Liver-LIVER_HEP-30m|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLIC5 MEF2C BRD9

4.08e-04180363dd1b10c7f5a0fbc63163844ca1882884a24a84d3
ToppCelldroplet-Liver-LIVER_HEP|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation

CLIC5 MEF2C BRD9

4.08e-04180363423454e3390080ae03bb3cbb267255ebfe4df080
ToppCellFetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_1/2_(AT1/AT2-like)-D088|Fetal_29-31_weeks / Lineage, Cell type, age group and donor

CLIC5 LDLR LRP8

4.15e-04181363576da14ab3107f89e1f44a4a439d1bef5bb42370
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell-Podocyte|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NPAS3 GRIK2 CLIC5

4.15e-041813635bf7aa43f6e6ecce15c95928b91195544d6928c4
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NPAS3 CLIC5 SIPA1L2

4.15e-041813635f2d3a08577c440c944778d07aa993c6e7873f3d
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

NPAS3 CLIC5 SIPA1L2

4.15e-04181363c7c5f7d4c397b4613c772413a0a679377efffff3
ToppCellrenal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Renal_corpuscle_epithelial_cell-glomerular_visceral_epithelial_cell|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group

NPAS3 GRIK2 CLIC5

4.15e-041813638e751f5d7cd2d328ec0196d874e8a507e8c4e1a9
ToppCellControl-Epithelial_cells-Airway_club|Control / group, cell type (main and fine annotations)

CLIC5 LDLR KIAA1217

4.15e-04181363c755d23dd9aabc717dc73e2b3fa99a1f751e6507
ToppCellAnterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_E_(THEMIS)-Glut_D_(IT_RORB_THEMIS_LINC00507)_6-Exc_L6_THEMIS_LINC00343|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

FSTL4 ANKMY2 LRP1B

4.21e-04182363cc6f9d606a4f8717dc44928ceec2a257636043fd
ToppCell3'-GW_trimst-1.5-SmallIntestine-Neuronal-neuron_precursor-cycling_neuroblast|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

GRIK2 CLSPN LRP8

4.21e-04182363e6968e0bd9cef92052d04ac54e2dd746b37623f6
ToppCelldroplet-Lung-30m-Hematologic-lymphocytic-plasma_cell-plasma_cell|30m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

RHOBTB1 ST14 MEF2C

4.28e-041833630f6799e4f058bed546fe5759502430f4a19635da
DrugNafronyl oxalate [3200-06-4]; Down 200; 8.4uM; HL60; HT_HG-U133A

STAM2 RHOBTB1 HNRNPUL2 ST14 MEF2C SCAPER

5.75e-071953661267_DN
DrugCamptothecine (S,+) [7689-03-4]; Down 200; 11.4uM; PC3; HT_HG-U133A

RSBN1 PUM1 PHF3 LDLR MEF2C

9.03e-061803654541_DN
DrugSulfamethoxypyridazine [80-35-3]; Down 200; 14.2uM; HL60; HT_HG-U133A

RHOBTB1 HNRNPUL2 PHF3 MEF2C SCAPER

1.47e-051993652550_DN
Diseasemyofibrillar myopathy 5 (implicated_via_orthology)

FLNA FLNC

4.10e-063352DOID:0080096 (implicated_via_orthology)
Diseasedistal muscular dystrophy 4 (implicated_via_orthology)

FLNA FLNC

4.10e-063352DOID:0111190 (implicated_via_orthology)
Diseaseexecutive function measurement

NPAS3 PHF20L1 LRP1B MEF2C LRP8

7.75e-05376355EFO_0009332
Diseasesevere acute respiratory syndrome, COVID-19

CLIC5 SIPA1L2 LRP1B ANKRD54 KIAA1217

1.74e-04447355EFO_0000694, MONDO_0100096
Diseasecoronary artery calcification

FSTL4 GRIK2 LRP1B LDLR MEF2C

1.80e-04450355EFO_0004723
Diseasediet measurement

NPAS3 STAM2 GRIK2 LRP1B LDLR MEF2C KIAA1217

1.98e-041049357EFO_0008111
DiseaseDyslipidemias

HP LDLR

3.71e-0424352C0242339
Diseaseunipolar depression, neuroticism measurement

PHF3 KIAA1217

3.71e-0424352EFO_0003761, EFO_0007660
DiseaseDyslipoproteinemias

HP LDLR

3.71e-0424352C0598784
Diseasearteriosclerosis (is_implicated_in)

HP LDLR

6.22e-0431352DOID:2349 (is_implicated_in)
Diseasepack-years measurement, systolic blood pressure

SIPA1L2 LRP1B

7.49e-0434352EFO_0006335, EFO_0006526
Diseaseoral microbiome measurement

GRIK2 KIAA1217

1.14e-0342352EFO_0801229

Protein segments in the cluster

PeptideGeneStartEntry
EDGADPCAADDKGRT

ANKRD54

131

Q6NXT1
DDNDDGCLKEPKSSG

CHD5

121

Q8TDI0
CDTEGEADDFDPGKK

BRD9

101

Q9H8M2
GNKKLDEGEECDCGP

ADAM7

406

Q9H2U9
PEEIDANTCGEDKGS

CLIC5

316

Q9NZA1
EKDCEDGSDEKGCNG

LRP1B

1076

Q9NZR2
LCNGKKDCPDGSDEG

LRP1B

1156

Q9NZR2
SGNDVTDIADDGCPK

HP

21

P00738
TSGGEKPNKDLESCS

GPATCH4

116

Q5T3I0
PSQAKIECDDKGDGS

FLNC

611

Q14315
DDQDSEKSKPAGSDG

HNRNPUL2

181

Q1KMD3
KGLNGCDSPDPDADD

MEF2C

91

Q06413
GPRDADSDENDKGEK

PUM1

241

Q14671
CENGADDDKLSKPVA

C6orf132

601

Q5T0Z8
GGPEECKNKDDQGFE

ICE2

476

Q659A1
PSQAKIECDDKGDGS

FLNA

616

P21333
KQDLDEDLLGCSPGD

FSTL4

206

Q6MZW2
DSNPEDSGEGKKESL

ANKMY2

406

Q8IV38
GNGCPEEESKEASAL

GRIK2

801

Q13002
SEDKPLSCGTNSGKE

CEP295

461

Q9C0D2
ESKDDDGKPKCQTGG

SCAPER

36

Q9BY12
GDRDCKDKSDEADCP

LRP8

281

Q14114
QDCKSLADPGSSDDD

PHF20L1

871

A8MW92
DGDPSSCGTDLKHKD

RSBN1

201

Q5VWQ0
DEGDGKSNDLVLSCP

SIPA1L2

396

Q9P2F8
CKGEDATDDQFESPK

KIAA1217

1556

Q5T5P2
PEPDRKKSGNACDND

NPAS3

496

Q8IXF0
EESPNGSEGACEKEK

RHOBTB1

301

O94844
GKQPSKLDEDDSCSL

CLSPN

751

Q9HAW4
GAPKKSEDCSGEGKD

TMIGD2

201

Q96BF3
GCPESKNEAEGADDL

SPRED1

126

Q7Z699
SKGNPECDGKEDCSD

ST14

581

Q9Y5Y6
EDGLDSKHKCNNPGE

PHF3

231

Q92576
DICDKVGSTPNGAKD

STAM2

31

O75886
KDQPPGSDSDEDCQK

SCN11A

476

Q9UI33
SKENECDPEEDLGKC

USP1

371

O94782
CDGGPDCKDKSDEEN

LDLR

216

P01130