Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	methylated histone binding	NCAPD3 LRWD1 PHF8 MORC4 CDYL2 CDYL TAF1 MORC3	3.96e-08	86	117	8	GO:0035064
GeneOntologyMolecularFunction	methylation-dependent protein binding	NCAPD3 LRWD1 PHF8 MORC4 CDYL2 CDYL TAF1 MORC3	4.75e-08	88	117	8	GO:0140034
GeneOntologyMolecularFunction	histone binding	NCAPD3 LRWD1 IPO7 PHF8 MORC4 CDYL2 CDYL TAF1 MORC3	2.64e-05	265	117	9	GO:0042393
GeneOntologyMolecularFunction	modification-dependent protein binding	NCAPD3 LRWD1 PHF8 MORC4 CDYL2 CDYL TAF1 MORC3	2.92e-05	206	117	8	GO:0140030
GeneOntologyMolecularFunction	amino-acid betaine transmembrane transporter activity	SLC22A4 SLC22A5	2.03e-04	4	117	2	GO:0015199
GeneOntologyMolecularFunction	histone H3K27me2/H3K27me3 demethylase activity	PHF8 UTY	3.37e-04	5	117	2	GO:0071558
GeneOntologyMolecularFunction	phosphoric ester hydrolase activity	PDE3B NT5DC4 PDE7A INPPL1 APEX1 PPP1CB SYNJ1 CTDP1 G6PC1	4.52e-04	386	117	9	GO:0042578
GeneOntologyMolecularFunction	carnitine transmembrane transporter activity	SLC22A4 SLC22A5	5.03e-04	6	117	2	GO:0015226
GeneOntologyMolecularFunction	interleukin-6 receptor binding	PYCARD IL6ST	7.01e-04	7	117	2	GO:0005138
GeneOntologyMolecularFunction	dolichyl-phosphate-mannose-protein mannosyltransferase activity	POMT2 TMTC3	9.31e-04	8	117	2	GO:0004169
GeneOntologyMolecularFunction	modified amino acid transmembrane transporter activity	SLC3A1 SLC22A4 SLC22A5	9.41e-04	33	117	3	GO:0072349
Domain	Rhomboid_SP	RHBDF1 RHBDF2	3.76e-05	2	115	2	PF12595
Domain	Rhomboid_SP	RHBDF1 RHBDF2	3.76e-05	2	115	2	IPR022241
Pubmed	A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.	SMG1 TOPAZ1 APEX1 XIAP LRRK1 DNAH7 SLC3A1 PPP1CB NF1 MAGED2 GPR149	2.29e-07	420	119	11	28065597
Pubmed	PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression.	NCAPD3 PHF8 HCFC1	7.75e-07	6	119	3	20622854
Pubmed	A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome.	KANSL1L SMG1 IPO7 OBSCN MDM2 PPP1CB DST RETREG1 TAF1 UTRN IL6ST	1.20e-06	497	119	11	23414517
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	LRWD1 RHBDF1 RHBDF2 INPPL1 OBSCN TRMT1 RELB LRRK1 MED13L TEP1 ACOX3 DST SYNJ1 CTDP1 DHX34 HCFC1	1.21e-06	1105	119	16	35748872
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	LRWD1 IPO7 APEX1 PHF8 MIDEAS GNL2 SHPRH CDYL TAF1 MORC3 USP48 HCFC1	1.27e-06	608	119	12	36089195
Pubmed	Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.	RGPD2 SATB2 NUP107 USP24 MORC4 DST SYNJ1 ANAPC1 TAF1 UTRN	1.88e-06	418	119	10	34709266
Pubmed	WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage.	LRWD1 MIDEAS PPP1CB MAGED2 ANAPC1 SHPRH TAF1 USP48 UTRN	9.06e-06	394	119	9	27248496
Pubmed	Haplotype in the IBD5 region is associated with refractory Crohn's disease in Slovenian patients and modulates expression of the SLC22A5 gene.	SLC22A4 SLC22A5	1.16e-05	2	119	2	21695374
Pubmed	Analysis of the influence of OCTN1/2 variants within the IBD5 locus on disease susceptibility and growth indices in early onset inflammatory bowel disease.	SLC22A4 SLC22A5	1.16e-05	2	119	2	16469794
Pubmed	Gene expression of carnitine organic cation transporters 1 and 2 (OCTN) is downregulated in patients with ulcerative colitis.	SLC22A4 SLC22A5	1.16e-05	2	119	2	21910182
Pubmed	GADD34 activates p53 and may have utility as a marker of atherosclerosis.	PPP1R15A MDM2	1.16e-05	2	119	2	37228401
Pubmed	Association of SLC22A4/5 polymorphisms with steroid responsiveness of inflammatory bowel disease in Japan.	SLC22A4 SLC22A5	1.16e-05	2	119	2	18274826
Pubmed	Attenuation of Excess TNF-α Release in Crohn's Disease by Silencing of iRHOMs 1/2 and the Restoration of TGF-β Mediated Immunosuppression Through Modulation of TACE Trafficking.	RHBDF1 RHBDF2	1.16e-05	2	119	2	35585977
Pubmed	Substrate discrimination by ergothioneine transporter SLC22A4 and carnitine transporter SLC22A5: gain-of-function by interchange of selected amino acids.	SLC22A4 SLC22A5	1.16e-05	2	119	2	19814996
Pubmed	Mammalian iRhoms have distinct physiological functions including an essential role in TACE regulation.	RHBDF1 RHBDF2	1.16e-05	2	119	2	23969955
Pubmed	Identification and functional characterization of a voltage-gated chloride channel and its novel splice variant in taste bud cells.	CLCN4 CLCN5	1.16e-05	2	119	2	16129671
Pubmed	Core Binding Factor β Protects HIV, Type 1 Accessory Protein Viral Infectivity Factor from MDM2-mediated Degradation.	MDM2 CBFB	1.16e-05	2	119	2	27758855
Pubmed	XIAP inhibits autophagy via XIAP-Mdm2-p53 signalling.	XIAP MDM2	1.16e-05	2	119	2	23749209
Pubmed	Oxaliplatin transport mediated by organic cation/carnitine transporters OCTN1 and OCTN2 in overexpressing human embryonic kidney 293 cells and rat dorsal root ganglion neurons.	SLC22A4 SLC22A5	1.16e-05	2	119	2	21606177
Pubmed	Genes adapt to outsmart gene-targeting strategies in mutant mouse strains by skipping exons to reinitiate transcription and translation.	RHBDF1 RHBDF2	1.16e-05	2	119	2	32646486
Pubmed	Gene conversion and purifying selection of a placenta-specific ERV-V envelope gene during simian evolution.	ERVV-2 ERVV-1	1.16e-05	2	119	2	18826608
Pubmed	Transport of ipratropium, an anti-chronic obstructive pulmonary disease drug, is mediated by organic cation/carnitine transporters in human bronchial epithelial cells: implications for carrier-mediated pulmonary absorption.	SLC22A4 SLC22A5	1.16e-05	2	119	2	20020740
Pubmed	Ubiquitin-specific peptidase 48 regulates Mdm2 protein levels independent of its deubiquitinase activity.	MDM2 USP48	1.16e-05	2	119	2	28233861
Pubmed	Association of the organic cation transporter OCTN genes with Crohn's disease in the Spanish population.	SLC22A4 SLC22A5	1.16e-05	2	119	2	16333318
Pubmed	Association of the OCTN1/1672T variant with increased risk for colorectal cancer in young individuals and ulcerative colitis patients.	SLC22A4 SLC22A5	1.16e-05	2	119	2	21793125
Pubmed	SLC22A4 and SLC22A5 gene polymorphisms and Crohn's disease in the Chinese Han population.	SLC22A4 SLC22A5	1.16e-05	2	119	2	19659785
Pubmed	Characterization of organic cation/carnitine transporter family in human sperm.	SLC22A4 SLC22A5	1.16e-05	2	119	2	12788076
Pubmed	Association between OCTN1/2 gene polymorphisms (1672C-T, 207G-C) and susceptibility of Crohn's disease: a meta-analysis.	SLC22A4 SLC22A5	1.16e-05	2	119	2	21706137
Pubmed	Differential evolutionary fate of an ancestral primate endogenous retrovirus envelope gene, the EnvV syncytin, captured for a function in placentation.	ERVV-2 ERVV-1	1.16e-05	2	119	2	23555306
Pubmed	Expression and functional analysis of intestinal organic cation/L-carnitine transporter (OCTN) in Crohn's disease.	SLC22A4 SLC22A5	1.16e-05	2	119	2	22325173
Pubmed	Chloride/proton antiporter activity of mammalian CLC proteins ClC-4 and ClC-5.	CLCN4 CLCN5	1.16e-05	2	119	2	16034421
Pubmed	Molecular and functional characterization of organic cation/carnitine transporter family in mice.	SLC22A4 SLC22A5	1.16e-05	2	119	2	11010964
Pubmed	The eNOS-NO pathway attenuates kidney dysfunction via suppression of inflammasome activation in aldosterone-induced renal injury model mice.	PYCARD NOS3	1.16e-05	2	119	2	30281670
Pubmed	Expression patterns of the organic cation/carnitine transporter family in adult murine brain.	SLC22A4 SLC22A5	1.16e-05	2	119	2	17576045
Pubmed	Functional genetic variation in the basal promoter of the organic cation/carnitine transporters OCTN1 (SLC22A4) and OCTN2 (SLC22A5).	SLC22A4 SLC22A5	1.16e-05	2	119	2	19141711
Pubmed	Contribution of the IBD5 locus to Crohn's disease in the Swedish population.	SLC22A4 SLC22A5	1.16e-05	2	119	2	17340776
Pubmed	Prevalence of SLC22A4 1672T and SLC22A5 -207C combination defined TC haplotype in Hungarian ulcerative colitis patients.	SLC22A4 SLC22A5	1.16e-05	2	119	2	17387389
Pubmed	Tooth loss and adiposity: possible role of carnitine transporter (OCTN1/2) polymorphisms in women but not in men.	SLC22A4 SLC22A5	1.16e-05	2	119	2	32964310
Pubmed	Direct or indirect association in a complex disease: the role of SLC22A4 and SLC22A5 functional variants in Crohn disease.	SLC22A4 SLC22A5	1.16e-05	2	119	2	16835882
Pubmed	[Possible role of selected IGR and SLC22A4/SLC22A5 loci in development of inflammatory bowel diseases].	SLC22A4 SLC22A5	1.16e-05	2	119	2	19581171
Pubmed	Polymorphisms in the organic cation transporter genes SLC22A4 and SLC22A5 and Crohn's disease in a New Zealand Caucasian cohort.	SLC22A4 SLC22A5	1.16e-05	2	119	2	16519742
Pubmed	Functional activity of L-carnitine transporters in human airway epithelial cells.	SLC22A4 SLC22A5	1.16e-05	2	119	2	26607009
Pubmed	OCTNs: will the real IBD5 gene please stand up?	SLC22A4 SLC22A5	1.16e-05	2	119	2	16773684
Pubmed	L-Tetrahydropalmatine Induces Apoptosis in EU-4 Leukemia Cells by Down-Regulating X-Linked Inhibitor of Apoptosis Protein and Increases the Sensitivity Towards Doxorubicin.	XIAP MDM2	1.16e-05	2	119	2	28721806
Pubmed	Association of iRhom1 and iRhom2 expression with prognosis in patients with cervical cancer and possible signaling pathways.	RHBDF1 RHBDF2	1.16e-05	2	119	2	31661139
Pubmed	Organic cation/carnitine transporter family expression patterns in adult murine heart.	SLC22A4 SLC22A5	1.16e-05	2	119	2	19233567
Pubmed	Expression and localization of carnitine/organic cation transporter OCTN1 and OCTN2 in ocular epithelium.	SLC22A4 SLC22A5	1.16e-05	2	119	2	18641280
Pubmed	Evidence for association of OCTN genes and IBD5 with ulcerative colitis.	SLC22A4 SLC22A5	1.16e-05	2	119	2	16361305
Pubmed	Evidence for the association of the SLC22A4 and SLC22A5 genes with type 1 diabetes: a case control study.	SLC22A4 SLC22A5	1.16e-05	2	119	2	16796743
Pubmed	Polymorphisms in OCTN1 and OCTN2 transporters genes are associated with prolonged time to progression in unresectable gastrointestinal stromal tumours treated with imatinib therapy.	SLC22A4 SLC22A5	1.16e-05	2	119	2	23127916
Pubmed	LPS-induced inflammation delays the transportation of ASP+ due to down-regulation of OCTN1/2 in alveolar epithelial cells.	SLC22A4 SLC22A5	1.16e-05	2	119	2	31591905
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	SMG1 NCAPD3 SATB2 IPO7 USP24 MORC4 DNAH7 DNAH12 NF1 TMTC3 UTY	1.28e-05	638	119	11	31182584
Pubmed	Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.	LRWD1 IPO7 NUP107 USP24 ZC3HC1 NF1 MAGED2 ANAPC1 BUB3 USP48	3.32e-05	582	119	10	20467437
Pubmed	Evidence of evolutionary up-regulation of the single active X chromosome in mammals based on Clc4 expression levels in Mus spretus and Mus musculus.	CLCN4 CLCN5	3.47e-05	3	119	2	9256467
Pubmed	Structural modeling defines transmembrane residues in ADAM17 that are crucial for Rhbdf2-ADAM17-dependent proteolysis.	RHBDF1 RHBDF2	3.47e-05	3	119	2	28104813
Pubmed	A risk haplotype in the Solute Carrier Family 22A4/22A5 gene cluster influences phenotypic expression of Crohn's disease.	SLC22A4 SLC22A5	3.47e-05	3	119	2	15685536
Pubmed	Functional variants of OCTN cation transporter genes are associated with Crohn disease.	SLC22A4 SLC22A5	3.47e-05	3	119	2	15107849
Pubmed	Transcription factor TAFII250 promotes Mdm2-dependent turnover of p53.	MDM2 TAF1	3.47e-05	3	119	2	17237821
Pubmed	Contribution of OCTN variants within the IBD5 locus to pediatric onset Crohn's disease.	SLC22A4 SLC22A5	3.47e-05	3	119	2	16771961
Pubmed	Polymorphisms in the IBD5 locus are associated with Crohn disease in pediatric Ashkenazi Jewish patients.	SLC22A4 SLC22A5	3.47e-05	3	119	2	19412005
Pubmed	Transcription factor TAFII250 phosphorylates the acidic domain of Mdm2 through recruitment of protein kinase CK2.	MDM2 TAF1	3.47e-05	3	119	2	18548200
Pubmed	Structural insight into M-band assembly and mechanics from the titin-obscurin-like-1 complex.	OBSCN OBSL1	3.47e-05	3	119	2	20133654
Pubmed	Expression of the organic cation/carnitine transporter family (Octn1,-2 and-3) in mdx muscle and heart: Implications for early carnitine therapy in Duchenne muscular dystrophy to improve cellular carnitine homeostasis.	SLC22A4 SLC22A5	3.47e-05	3	119	2	32070725
Pubmed	Variants of OCTN1-2 cation transporter genes are associated with both Crohn's disease and ulcerative colitis.	SLC22A4 SLC22A5	3.47e-05	3	119	2	16441470
Pubmed	IGR2096a_1 T and IGR2198a_1 C alleles on IBD5 locus of chromosome 5q31 region confer risk for Crohn's disease in Hungarian patients.	SLC22A4 SLC22A5	3.47e-05	3	119	2	19214536
Pubmed	The contribution of OCTN1/2 variants within the IBD5 locus to disease susceptibility and severity in Crohn's disease.	SLC22A4 SLC22A5	3.47e-05	3	119	2	16344054
Pubmed	OCTN and CARD15 gene polymorphism in Chinese patients with inflammatory bowel disease.	SLC22A4 SLC22A5	3.47e-05	3	119	2	18756601
Pubmed	Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway.	RELB FBXW7	3.47e-05	3	119	2	22864569
Pubmed	TAF1 differentially enhances androgen receptor transcriptional activity via its N-terminal kinase and ubiquitin-activating and -conjugating domains.	MDM2 TAF1	3.47e-05	3	119	2	20181722
Pubmed	The MDM2 C-terminal region binds to TAFII250 and is required for MDM2 regulation of the cyclin A promoter.	MDM2 TAF1	3.47e-05	3	119	2	9388200
Pubmed	Binding of Myomesin to Obscurin-Like-1 at the Muscle M-Band Provides a Strategy for Isoform-Specific Mechanical Protection.	OBSCN OBSL1	3.47e-05	3	119	2	27989621
Pubmed	FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system.	DISC1 FBXW7	3.47e-05	3	119	2	28727686
Pubmed	Role of iRhoms 1 and 2 in Endochondral Ossification.	RHBDF1 RHBDF2	3.47e-05	3	119	2	33227998
Pubmed	Redox factor-1 activates endothelial SIRTUIN1 through reduction of conserved cysteine sulfhydryls in its deacetylase domain.	APEX1 NOS3	3.47e-05	3	119	2	23755229
Pubmed	ADAM17 stabilizes its interacting partner inactive Rhomboid 2 (iRhom2) but not inactive Rhomboid 1 (iRhom1).	RHBDF1 RHBDF2	3.47e-05	3	119	2	32060096
Pubmed	Murine obscurin and Obsl1 have functionally redundant roles in sarcolemmal integrity, sarcoplasmic reticulum organization, and muscle metabolism.	OBSCN OBSL1	3.47e-05	3	119	2	31098411
Pubmed	Evidence for common genetic control in pathways of inflammation for Crohn's disease and psoriatic arthritis.	SLC22A4 SLC22A5	3.47e-05	3	119	2	16255050
Pubmed	Phosphorylation of iRhom2 at the plasma membrane controls mammalian TACE-dependent inflammatory and growth factor signalling.	RHBDF1 RHBDF2	3.47e-05	3	119	2	28432785
Pubmed	Regulation of XIAP translation and induction by MDM2 following irradiation.	XIAP MDM2	3.47e-05	3	119	2	19411066
Pubmed	Family-wide Characterization of Histone Binding Abilities of Human CW Domain-containing Proteins.	MORC4 MORC3	3.47e-05	3	119	2	26933034
Pubmed	Role of SLC22A4, SLC22A5, and RUNX1 genes in rheumatoid arthritis.	SLC22A4 SLC22A5	3.47e-05	3	119	2	16652416
Pubmed	Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling.	RHBDF1 RHBDF2	3.47e-05	3	119	2	21439629
Pubmed	Polymorphisms in the DLG5 and OCTN cation transporter genes in Crohn's disease.	SLC22A4 SLC22A5	3.47e-05	3	119	2	15955786
Pubmed	Lack of association between IBD5 and Crohn's disease in Japanese patients demonstrates population-specific differences in inflammatory bowel disease.	SLC22A4 SLC22A5	3.47e-05	3	119	2	16373276
Pubmed	Deorphaning a solute carrier 22 family member, SLC22A15, through functional genomic studies.	SLC22A4 SLC22A5	3.47e-05	3	119	2	33124720
Pubmed	MDM2 and Fbw7 cooperate to induce p63 protein degradation following DNA damage and cell differentiation.	MDM2 FBXW7	3.47e-05	3	119	2	20571051
Pubmed	Prevalence of SLC22A4, SLC22A5 and CARD15 gene mutations in Hungarian pediatric patients with Crohn's disease.	SLC22A4 SLC22A5	3.47e-05	3	119	2	17006998
Pubmed	Analysis of the function of ADAM17 in iRhom2 curly-bare and tylosis with esophageal cancer mutant mice.	RHBDF1 RHBDF2	3.47e-05	3	119	2	37282854
Pubmed	FBXW7 Confers Radiation Survival by Targeting p53 for Degradation.	MDM2 FBXW7	3.47e-05	3	119	2	31940492
Pubmed	Deletions in the cytoplasmic domain of iRhom1 and iRhom2 promote shedding of the TNF receptor by the protease ADAM17.	RHBDF1 RHBDF2	3.47e-05	3	119	2	26535007
Pubmed	Molecular basis of the head-to-tail assembly of giant muscle proteins obscurin-like 1 and titin.	OBSCN OBSL1	3.47e-05	3	119	2	20489725
Pubmed	Dynamic Protein Interactions of the Polycomb Repressive Complex 2 during Differentiation of Pluripotent Cells.	LRWD1 IPO7 NUP107 OBSL1 MORC4 CLK2 MORC3 BUB3 HCFC1	3.57e-05	469	119	9	27634302
Pubmed	Defining the membrane proteome of NK cells.	NCAPD3 PDE3B IPO7 NUP107 CBFB ACOX3 NF1 CLCN5 MAGED2 GNL2 DHX34 HCFC1 RUSF1 IL6ST	4.79e-05	1168	119	14	19946888
Pubmed	Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation.	NUP107 PYCARD IL6ST	4.97e-05	21	119	3	24407287
Pubmed	Fibril treatment changes protein interactions of tau and α-synuclein in human neurons.	SMG1 IPO7 NUP107 USP24 APEX1 CEP128 DST MAGED2 HCFC1	5.66e-05	498	119	9	36634849
Pubmed	Role of CARD15, DLG5 and OCTN genes polymorphisms in children with inflammatory bowel diseases.	SLC22A4 SLC22A5	6.93e-05	4	119	2	17451203
Pubmed	Polymorphisms in NEIL-2, APE-1, CYP2E1 and MDM2 Genes are Independent Predictors of Gastric Cancer Risk in a Northern Jiangsu Population (China).	APEX1 MDM2	6.93e-05	4	119	2	26373042
Pubmed	Risk factors for perianal Crohn's disease: the role of genotype, phenotype, and ethnicity.	SLC22A4 SLC22A5	6.93e-05	4	119	2	17509030
Pubmed	A contravention of Ohno's law in mice.	CLCN4 CLCN5	6.93e-05	4	119	2	7670497
Pubmed	Different chromosomal localization of the Clcn4 gene in Mus spretus and C57BL/6J mice.	CLCN4 CLCN5	6.93e-05	4	119	2	7670496
Interaction	DUXB interactions	SATB2 MORC4 MIDEAS DUXB	3.21e-06	18	118	4	int:DUXB
GeneFamily	Tetratricopeptide repeat domain containing\|Bardet-Biedl syndrome associated\|BBSome	RGPD2 TMTC3 FKBPL UTY TTC33	1.15e-04	115	75	5	769
GeneFamily	Zinc fingers CW-type	MORC4 MORC3	3.52e-04	7	75	2	96
GeneFamily	Chloride voltage-gated channels	CLCN4 CLCN5	7.48e-04	10	75	2	302
GeneFamily	Rhomboid family	RHBDF1 RHBDF2	1.50e-03	14	75	2	926
GeneFamily	Dyneins, axonemal	DNAH7 DNAH12	2.22e-03	17	75	2	536
GeneFamily	PHD finger proteins\|Lysine demethylases	PHF8 UTY	4.42e-03	24	75	2	485
GeneFamily	Phosphodiesterases	PDE3B PDE7A	4.42e-03	24	75	2	681
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	SMG1 PDE3B USP24 MED13L NF1 UTRN IL6ST	7.51e-07	188	119	7	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMG1 IPO7 RELB MIDEAS UTRN UTY	1.05e-05	185	119	6	eb7d3c1363d5fedc611f9c1a91ea823de251355e
ToppCell	P28-Endothelial-large_vessel_endothelial_cell\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CYP26B1 PPP1R15A DST UTRN NOS3 IL6ST	1.15e-05	188	119	6	263169029293e005bcffd87db20221fdd2d3917e
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYP26B1 ARMCX4 PPP1R15A DST UTRN NOS3	1.26e-05	191	119	6	3307dbccadb09c62b0e1c0235ec89bb294d748c3
ToppCell	kidney_cells-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	KANSL1L SLITRK4 SULT1C4 RNF180 UTY IL6ST	1.59e-05	199	119	6	174f6013af6eafa577f84205a62927f2b367fda3
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD4-T_CD4/CD8\|bone_marrow / Manually curated celltypes from each tissue	SMG1 PDE3B PDE7A UTY IL6ST	6.24e-05	156	119	5	1545169694f686d28648a68b552c2ae606599d66
ToppCell	10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	SMG1 PDE3B UTRN UTY IL6ST	7.46e-05	162	119	5	b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCell	Entopeduncular-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Tgfb2_(Tgfb2)--\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	SATB2 RHBDF2 OBSCN G6PC1	7.62e-05	84	119	4	43e77117579290446a7e386c0be3459d652d9384
ToppCell	Entopeduncular-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Tgfb2_(Tgfb2)\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	SATB2 RHBDF2 OBSCN G6PC1	7.62e-05	84	119	4	38a457a20701fe23c6326b7282cd0993cdd87082
ToppCell	Entopeduncular-Endothelial-ENDOTHELIAL_STALK-Flt1_2-Endothelial_Stalk.Flt1.Tgfb2_(Tgfb2)-\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	SATB2 RHBDF2 OBSCN G6PC1	7.62e-05	84	119	4	59d0415bb6b6b18a94d2c9c6289fa9cbcb2166e3
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYP26B1 ARMCX4 DST UTRN NOS3	8.37e-05	166	119	5	7a45785a40b7425f97be67bab1c5ceb69b2bd85a
ToppCell	PND14-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|PND14 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYP26B1 ARMCX4 DST UTRN NOS3	8.37e-05	166	119	5	bbd382812f8a84a5d99888de2d7cca3a8b5e4695
ToppCell	15-Distal-Epithelial-Multiciliated_precursor\|Distal / Age, Tissue, Lineage and Cell class	M1AP TCHH DNAH12 MDH1B IQUB	8.61e-05	167	119	5	442ea71a581ed5a547a214132b9f1b0243fd0895
ToppCell	MS-CD8-proli_CD4\|MS / Condition, Cell_class and T cell subcluster	RGPD2 CEP128 TMTC3 SHPRH MORC3	9.90e-05	172	119	5	0b6dd257110b3f17fa71ab18a165b091a9d5ae9a
ToppCell	facs-Lung-Endomucin_-18m-Myeloid-non-classical_monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SATB2 TRMT1 CEP128 M1AP CDYL	1.02e-04	173	119	5	c31076c725f4cd912c56903592a2d9356ae59f54
ToppCell	facs-Lung-Endomucin_-18m-Myeloid-Nonclassical_Monocyte\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SATB2 TRMT1 CEP128 M1AP CDYL	1.02e-04	173	119	5	a4ed191cfdf6588b7f3672995bf0a4fe9e4b8df6
ToppCell	Frontal_cortex-Neuronal-Excitatory-eN1(Slc17a7)-eN1_2-Nptxr-Excitatory_Neuron.Slc17a7.Nptxr-Drd1_(Deep_layer_pyramidal_cells)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	LRWD1 PHF8 GNL2 FKBPL TTC33	1.10e-04	176	119	5	3c76a5c4ca2b378667cb155fbb9675519572b35d
ToppCell	IIH-CD8-antiviral_CD4\|IIH / Condition, Cell_class and T cell subcluster	KANSL1L IRF7 ACOX3 CLK2 SLC22A5	1.13e-04	177	119	5	fe73608c40701eca88b260aeb5c0640d7bee72ba
ToppCell	droplet-Spleen-nan-24m-Hematologic-erythroblast\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	COX6B2 PPP1R15A PPP1CB SLC22A4 EIF2AK1	1.16e-04	178	119	5	9c4950357087212b2388116ba8866c359628694d
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYP26B1 ARMCX4 DST UTRN NOS3	1.26e-04	181	119	5	4d7793026373cbcf04b15c77f95f1025d07d4c00
ToppCell	facs-Lung-Endomucin_-18m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ARMCX4 DST TIMP4 UTRN NOS3	1.26e-04	181	119	5	4ea02344e1996f264dd5e14f3b19c8782ce41699
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	SATB2 LRRK1 DNAH7 CPNE4 FBXW7	1.29e-04	182	119	5	14a117c5e50db31ee1b2cf4df4d133451fd6d55f
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYP26B1 ARMCX4 DST UTRN NOS3	1.32e-04	183	119	5	3427f3cbe6ea81709750e7dd3ff378f03ae65eab
ToppCell	CV-Healthy-7\|CV / Virus stimulation, Condition and Cluster	PDE3B ZNF268 ARMCX4 TEP1 SLC22A5	1.36e-04	184	119	5	0e5cc77aaa73ceb791f8be7456177577fd2e5586
ToppCell	renal_medulla_nuclei-CKD+DKD_normotensive\|renal_medulla_nuclei / Celltypes from Cells and Nuclei per compartment and clinical group	PDE3B PDE7A RELB DST RETREG1	1.36e-04	184	119	5	d2bf0135eb56bb410997dccea39c5ede88a0617f
ToppCell	P28-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery\|P28 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CYP26B1 ZC3HC1 DST UTRN NOS3	1.36e-04	184	119	5	8ed22b1af04a711203293e7a8b3df6fb9222fad5
ToppCell	CV-Healthy-7\|Healthy / Virus stimulation, Condition and Cluster	PDE3B ZNF268 ARMCX4 TEP1 SLC22A5	1.39e-04	185	119	5	1979d189c204f4c2893e3170a514ee7d5523406c
ToppCell	droplet-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell-pulmonary_artery_endothelial_cell_l25\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CYP26B1 ARMCX4 DST UTRN NOS3	1.43e-04	186	119	5	9c7924875f70420720149287c500b4dfa8d24673
ToppCell	TCGA-Breast-Primary_Tumor-Breast_Carcinoma-Infiltrating_Ductal_Carcinoma-1\|TCGA-Breast / Sample_Type by Project: Shred V9	MED13L MDM2 MAGED2 SLC22A5 RETREG1	1.46e-04	187	119	5	a716b64ca03d9b61da765bf87f065ac9393303f1
ToppCell	droplet-Lung-18m-Endothelial-arterial_endothelial\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CYP26B1 ARMCX4 DST UTRN NOS3	1.46e-04	187	119	5	12129e02638c20d9b7c1c6e512d48bfd966e1029
ToppCell	droplet-Lung-18m-Endothelial-arterial_endothelial-pulmonary_artery_endothelial_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CYP26B1 ARMCX4 DST UTRN NOS3	1.46e-04	187	119	5	83930ef55191eff9006113feaeabb3c2fa21fd05
ToppCell	P07-Endothelial-large_vessel_endothelial_cell-endothelial_cell_of_artery\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CYP26B1 ARMCX4 PPP1R15A UTRN NOS3	1.50e-04	188	119	5	5bc1537e079c7435196c163bff5f639ea392a33a
ToppCell	droplet-Lung-nan-18m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYP26B1 ARMCX4 DST UTRN NOS3	1.50e-04	188	119	5	405efea75233ecf70f7d19b630230798d817b7f2
ToppCell	renal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Adaptive_/_Maladaptive_/_Repairing_Proximal_Tubule_Epithelial_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	SATB2 PDE7A SULT1C4 SLC3A1 RETREG1	1.54e-04	189	119	5	3b48b0d220cc24d5170713d61fa91f5bb6c21841
ToppCell	PND07-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYP26B1 ARMCX4 PPP1R15A UTRN NOS3	1.54e-04	189	119	5	9da012fdfa9a8d488cab710a463a1d70e89f990c
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYP26B1 ARMCX4 DST UTRN NOS3	1.58e-04	190	119	5	d87b9e9ca863270a9c7f61674271a6440c97d1f4
ToppCell	E18.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal-Deuterosomal_mature\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COX6B2 CEP128 DNAH12 MDH1B IQUB	1.62e-04	191	119	5	e8d56e9f43943e9cc4dce83f2c234f19c2dd487d
ToppCell	E18.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Deuterosomal\|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	COX6B2 CEP128 DNAH12 MDH1B IQUB	1.62e-04	191	119	5	52e8d7dfaf1ebb6df8bf3a1f4546af59faa67657
ToppCell	PND10-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|PND10 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYP26B1 ARMCX4 DST UTRN NOS3	1.62e-04	191	119	5	b270c3dd5952f56b9bdceabe13e298fe6757563b
ToppCell	P07-Endothelial-large_vessel_endothelial_cell\|P07 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	CYP26B1 PPP1R15A DST UTRN NOS3	1.62e-04	191	119	5	d162917816dd2e4767c97447c1cddae9397713ab
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC-AEC-AEC_mature\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYP26B1 ARMCX4 DST UTRN NOS3	1.65e-04	192	119	5	285a9d332a1e07b94f222d4b518dd56928b9e075
ToppCell	droplet-Lung-nan-18m-Endothelial-vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYP26B1 ARMCX4 DST NOS3 IL6ST	1.65e-04	192	119	5	45929c757d873fe314cc36d27abd265414635490
ToppCell	3'-Broncho-tracheal-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.1\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	LRWD1 DNAH7 DNAH12 MDH1B IQUB	1.65e-04	192	119	5	1b6cac8156e608061e1405e36e18d185b6fa8f6f
ToppCell	droplet-Lung-nan-18m-Endothelial-Vein_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CYP26B1 ARMCX4 DST NOS3 IL6ST	1.65e-04	192	119	5	beb336d3479821bdab7e8e2c58812f155e44e9a2
ToppCell	Control-CD8+_T_naive\|Control / Disease condition and Cell class	PDE3B PDE7A OBSCN RETREG1 IL6ST	1.70e-04	193	119	5	627d345baf1940218c61907305705298e473dbab
ToppCell	severe-low-quality_cells\|severe / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SMG1 USP24 TUBGCP5 TMTC3 UTRN	1.70e-04	193	119	5	9337bc93e3904c7fc7c93c328518bcd6453b1e8c
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PDE3B PDE7A OBSCN RETREG1 IL6ST	1.70e-04	193	119	5	d371403b51281a6e37652fa8dc1b2dd81d2ab371
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	PDE3B PDE7A OBSCN RETREG1 IL6ST	1.70e-04	193	119	5	6436d3bfce02d137b76e5c4c8b2fe27974c57c99
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive-\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.09)	PDE3B PDE7A OBSCN RETREG1 IL6ST	1.70e-04	193	119	5	3cde93bbfc1ae6fb586ae6b7aaa6ed8b5eee28a4
ToppCell	PBMC-Control-Lymphocyte-T/NK-CD8+_T-CD8+_T_naive\|Control / Location, Disease Group, Cell group, Cell class (2021.03.09)	PDE3B PDE7A OBSCN RETREG1 IL6ST	1.70e-04	193	119	5	d755dc6de4fbd4d8f5d8a88aac497e7b9e8b89de
ToppCell	P15-Endothelial-large_vessel_endothelial_cell\|P15 / developmental_time, Lineage, Cell group, Cell type, Cell type_cellcyc-phase	PPP1R15A DST UTRN NOS3 IL6ST	1.70e-04	193	119	5	5f9a7cd5f8eb9ac294cdb50518fedf872f3f78f5
ToppCell	PND03-Endothelial-Endothelial_blood-vessel-Macrovascular_EC\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	CYP26B1 ARMCX4 DST UTRN NOS3	1.70e-04	193	119	5	58c590dd6f21bc7ae58ae1729dd574c0f1069592
ToppCell	facs-Thymus-nan-3m\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KANSL1L SMG1 CBFB PPP1CB UTY	1.74e-04	194	119	5	f1661f9f2439fca5c1012c693b0744c4e3b90a9b
ToppCell	facs-Thymus-nan\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KANSL1L SMG1 CBFB PPP1CB UTY	1.74e-04	194	119	5	cda1b197efb199330ea7ab25a7cee22cae22589d
ToppCell	facs-Thymus-nan-3m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KANSL1L SMG1 CBFB PPP1CB UTY	1.74e-04	194	119	5	66c056232ac216780acf4cc8ea325bd8ed1909c9
ToppCell	mild_COVID-19_(asymptomatic)\|World / disease group, cell group and cell class (v2)	FOLR3 XIAP IRF7 RELB MED13L	1.82e-04	196	119	5	8cb3dcb3e5732f4bb060c87ca339b8997a1a8cd4
ToppCell	facs-Limb_Muscle-ForelimbandHindlimb-3m\|Limb_Muscle / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	IPO7 CBFB PPP1CB UTRN IL6ST	1.82e-04	196	119	5	151f1a29a91f8b234e9b6ed062666357a2f69128
ToppCell	PBMC_fresh-frozen-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-mature_alpha-beta_T_cell\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	PDE3B APEX1 PPP1CB RETREG1 IL6ST	1.86e-04	197	119	5	479841809554a9d0b1e4f23da6e657392b0f4971
ToppCell	PSB-critical-LOC-Epithelial-Ciliated\|LOC / Location, Severity, dps_group, Lineage and Cell class of Upper airway (combined)	DNAH7 DNAH12 SLC22A4 MDH1B IQUB	1.86e-04	197	119	5	6865f4831eb23794fb88a8649d48d497bbae3f44
ToppCell	severe-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SMG1 PDE3B USP24 TUBGCP5 UTRN	1.86e-04	197	119	5	57ebd552f10d6278623b52a3d484d4b91ae1d028
ToppCell	healthy_donor-Lymphocytic-T_cell-CD4+_Naive_T_cell\|healthy_donor / Disease condition, Lineage, Cell class and subclass	PDE3B PDE7A OBSCN RETREG1 IL6ST	1.86e-04	197	119	5	cf72160f03105876641fa6fdc7405e339eb084c7
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Distal_tubule_epithelial_cell-kidney_loop_of_Henle_thick_ascending_limb_epithelial_cell-Cortical_Thick_Ascending_Limb_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FOLR3 SLITRK4 OBSL1 SLC3A1 CLCN5	1.86e-04	197	119	5	4ea3f57cd88b8a6bb7cb4b9e3545c0fa8f331886
ToppCell	facs-Tongue-nan-3m-Epithelial\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMG1 IPO7 CBFB PPP1CB DST	1.91e-04	198	119	5	2f03f8897dd7cce6d8296638e14e11ec16bcf624
ToppCell	critical-Epithelial-Ciliated\|Epithelial / Severity, Lineage and Cell class of Nasopharyngeal (NS) Samples from Patients and Controls	DNAH7 DNAH12 SLC22A4 MDH1B IQUB	1.91e-04	198	119	5	ee2c8385c0bf4ea9f5c9517b52cf131af3fbdd40
ToppCell	facs-Tongue-nan-3m\|Tongue / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	SMG1 IPO7 CBFB PPP1CB DST	1.91e-04	198	119	5	f2a4057f038ef7225a5b98a7ab068c30dff4eadd
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	SMG1 PDE3B USP24 UTRN UTY	1.95e-04	199	119	5	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	Tracheal-NucSeq\|Tracheal / Cell types per location group and 10X technology with lineage, and cell group designations	MED13L NF1 UTRN UTY FBXW7	1.95e-04	199	119	5	94b94b17ca18b8dc27b91da1f2ccf89e03cc7035
ToppCell	Brain_organoid-organoid_Tanaka_cellReport-3m-Mesenchymal-Cilia-bearing_cell\|3m / Sample Type, Dataset, Time_group, and Cell type.	ISM2 DNAH7 DNAH12 MDH1B IQUB	2.00e-04	200	119	5	0d14a950172a56b11fdebee8f4e13b0c10e0d592
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-Macroglial-Astrocyte\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	WNT3 USP24 MORC4 MDH1B NOS3	2.00e-04	200	119	5	b9bd6c4381c92bfc1bfff9aa778a62a41d08f1ef
Drug	Ticarcillin sodium [4697-14-7]; Down 200; 9.4uM; HL60; HT_HG-U133A	KANSL1L RHBDF1 RELB MDM2 CLCN4 CLCN5 SLITRK5 UTY IL6ST	7.14e-07	195	116	9	6146_DN
Drug	Mephenesin [59-47-2]; Down 200; 22uM; HL60; HT_HG-U133A	PDE3B INPPL1 TUBGCP5 NF1 MAGED2 CDYL TAF1 EIF2AK1 UTRN	7.77e-07	197	116	9	2342_DN
Drug	Metronidazole [443-48-1]; Down 200; 23.4uM; MCF7; HT_HG-U133A	DUS4L HAUS5 NF1 CTDP1 DHX34 UTRN UTY HCFC1 IL6ST	8.11e-07	198	116	9	1503_DN
Drug	Thyroxine (L) [51-48-9]; Down 200; 5.2uM; PC3; HT_HG-U133A	KANSL1L ZNF268 RETREG1 SLITRK5 TAF1 DHX34 UTRN RUSF1 FBXW7	8.46e-07	199	116	9	4069_DN
Drug	Harpagoside [19210-12-9]; Down 200; 8uM; MCF7; HT_HG-U133A	PPP1R15A NF1 CTDP1 DHX34 UTRN UTY IL6ST FBXW7	6.21e-06	191	116	8	4981_DN
Drug	Biperiden hydrochloride [1235-82-1]; Down 200; 11.4uM; MCF7; HT_HG-U133A	POMT2 DOK1 PDE3B MDM2 NF1 RETREG1 TAF1 UTRN	6.96e-06	194	116	8	3321_DN
Drug	5230742; Up 200; 17uM; MCF7; HT_HG-U133A_EA	POMT2 DOK1 PDE3B PPP1R15A MDM2 TCHH RETREG1 EIF2AK1	6.96e-06	194	116	8	862_UP
Drug	Bephenium hydroxynaphthoate [3818-50-6]; Down 200; 9uM; MCF7; HT_HG-U133A	POMT2 MDM2 TEP1 NF1 SYNJ1 DHX34 HCFC1 IL6ST	6.96e-06	194	116	8	5263_DN
Drug	Amiodarone hydrochloride [19774-82-4]; Down 200; 5.8uM; MCF7; HT_HG-U133A	DOK1 PDE3B NF1 SYNJ1 DHX34 UTRN UTY IL6ST	7.23e-06	195	116	8	5618_DN
Drug	Nabumetone [42924-53-8]; Down 200; 17.6uM; MCF7; HT_HG-U133A	PDE3B TUBGCP5 SLC3A1 NF1 TAF1 UTY IL6ST TTC33	7.23e-06	195	116	8	5428_DN
Drug	Lumicolchicine gamma [6901-14-0]; Up 200; 10uM; MCF7; HT_HG-U133A	PDE3B PHF8 MDM2 NF1 CTDP1 UTRN UTY RUSF1	7.51e-06	196	116	8	3254_UP
Drug	Isosorbide dinitrate [87-33-2]; Down 200; 17uM; PC3; HT_HG-U133A	PDE3B ZNF268 PHF8 SLC3A1 TIMP4 DHX34 UTY IL6ST	7.51e-06	196	116	8	3720_DN
Drug	Tropine [120-29-6]; Down 200; 28.4uM; HL60; HT_HG-U133A	RHBDF1 RHBDF2 SLC3A1 CLCN4 RETREG1 SLITRK5 IL6ST TTC33	7.51e-06	196	116	8	6147_DN
Drug	Meropenem [96036-03-2]; Down 200; 10.4uM; MCF7; HT_HG-U133A	RHBDF2 HAUS5 IRF7 PPP1R15A TUBGCP5 USP48 RUSF1 FBXW7	8.09e-06	198	116	8	7180_DN
Drug	Diethylstilbestrol [56-53-1]; Down 200; 15uM; MCF7; HT_HG-U133A	DISC1 RELB BCO1 NF1 TAF1 USP48 HCFC1 IL6ST	8.09e-06	198	116	8	3895_DN
Drug	Ondansetron Hydrochloride [103639-04-9]; Up 200; 12.2uM; MCF7; HT_HG-U133A	DNAH7 ACOX3 SLC3A1 RETREG1 CDYL TAF1 TTC33 FBXW7	8.09e-06	198	116	8	6270_UP
Drug	Trichostatin A, from Streptomyces sp.; Down 200; 0.1uM; PC3; HT_HG-U133A	INPPL1 RELB LRRK1 TEP1 TUBGCP5 TAF1 HCFC1 FBXW7	8.39e-06	199	116	8	4526_DN
Drug	Eburnamonine (-) [4880-88-0]; Down 200; 13.6uM; MCF7; HT_HG-U133A	KANSL1L PDE3B NF1 SLC22A4 RETREG1 BUB3 USP48 HCFC1	8.39e-06	199	116	8	2781_DN
Drug	Edrophonium chloride [116-38-1]; Down 200; 19.8uM; MCF7; HT_HG-U133A	POMT2 USP24 MDM2 NF1 CLCN5 USP48 DHX34 RUSF1	8.70e-06	200	116	8	5001_DN
Drug	Etanidazole [22668-01-5]; Down 200; 18.6uM; HL60; HT_HG-U133A	KANSL1L HAUS5 ACOX3 NF1 MAGED2 RETREG1 CDYL TAF1	8.70e-06	200	116	8	2510_DN
Drug	Pralidoxime chloride [51-15-0]; Up 200; 23.2uM; PC3; HT_HG-U133A	HAUS5 PPP1R15A PHF8 TEP1 ACOX3 CDYL HCFC1 IL6ST	8.70e-06	200	116	8	6283_UP
Drug	Prenylamine lactate [69-43-2]; Up 200; 9.6uM; HL60; HG-U133A	IRF7 RELB ACOX3 NF1 MAGED2 SLC22A4 UTY	4.46e-05	184	116	7	1737_UP
Drug	Isoconazole [27523-40-6]; Up 200; 9.6uM; MCF7; HT_HG-U133A	DOK1 KANSL1L RELB PPP1R15A PHF8 BCO1 CLCN4	4.78e-05	186	116	7	2218_UP
Drug	Metergoline [17692-51-2]; Up 200; 10uM; MCF7; HT_HG-U133A	POMT2 MED13L PPP1R15A TEP1 CTDP1 RUSF1 IL6ST	5.65e-05	191	116	7	5344_UP
Drug	Hexetidine [141-94-6]; Down 200; 11.8uM; MCF7; HT_HG-U133A	DOK1 DISC1 TEP1 NF1 SYNJ1 UTRN FBXW7	5.84e-05	192	116	7	3318_DN
Drug	Cyclobenzaprine hydrochloride [6202-23-9]; Up 200; 12.8uM; MCF7; HT_HG-U133A	POMT2 KANSL1L CYP26B1 SLC3A1 BCO1 CLCN4 USP48	6.03e-05	193	116	7	4834_UP
Drug	Tolnaftate [2398-96-1]; Down 200; 13uM; PC3; HT_HG-U133A	RELB MDM2 SLC3A1 CLCN5 RETREG1 SLITRK5 IL6ST	6.23e-05	194	116	7	4221_DN
Drug	Primidone [125-33-7]; Down 200; 18.4uM; PC3; HT_HG-U133A	CYP26B1 PPP1R15A NF1 CTDP1 DHX34 UTRN RUSF1	6.23e-05	194	116	7	6723_DN
Drug	Paclitaxel [33069-62-4]; Up 200; 4.6uM; MCF7; HT_HG-U133A	POMT2 CYP26B1 RELB PHF8 MDM2 UTRN IL6ST	6.44e-05	195	116	7	1542_UP
Drug	Minocycline hydrochloride [13614-98-7]; Down 200; 8uM; PC3; HT_HG-U133A	HAUS5 RELB MDM2 CLCN4 SLC22A4 UTRN HCFC1	6.44e-05	195	116	7	5077_DN
Drug	Azathymine, 6 [932-53-6]; Down 200; 31.4uM; MCF7; HT_HG-U133A	POMT2 PDE3B IRF7 PPP1R15A TEP1 UTY IL6ST	6.44e-05	195	116	7	4106_DN
Drug	Fenbufen [36330-85-5]; Down 200; 15.8uM; PC3; HT_HG-U133A	RELB ACOX3 NF1 TAF1 UTRN UTY FBXW7	6.44e-05	195	116	7	3721_DN
Drug	Benzbromarone [3562-84-3]; Down 200; 9.4uM; MCF7; HT_HG-U133A	POMT2 KANSL1L NF1 CTDP1 RETREG1 HCFC1 FBXW7	6.65e-05	196	116	7	5015_DN
Drug	Eucatropine hydrochloride [536-93-6]; Down 200; 12.2uM; MCF7; HT_HG-U133A	HAUS5 IRF7 TUBGCP5 NF1 CLCN5 CDYL HCFC1	6.65e-05	196	116	7	3416_DN
Drug	Theophylline monohydrate [5967-84-0]; Down 200; 20.2uM; MCF7; HT_HG-U133A	DOK1 PDE3B USP24 TCHH NF1 SLC22A5 CDYL	6.65e-05	196	116	7	4812_DN
Drug	Tremorine dihydrochloride [300-68-5]; Up 200; 15uM; MCF7; HT_HG-U133A	PDE3B NF1 RETREG1 CDYL USP48 HCFC1 FBXW7	6.65e-05	196	116	7	6273_UP
Drug	Phenylpropanolamine hydrochloride [154-41-6]; Down 200; 21.4uM; MCF7; HT_HG-U133A	POMT2 RHBDF2 HAUS5 TEP1 SLC3A1 CTDP1 RETREG1	6.65e-05	196	116	7	3217_DN
Drug	Retinoic acid [302-79-4]; Down 200; 13.4uM; PC3; HT_HG-U133A	POMT2 DISC1 LRRK1 MDM2 DHX34 UTRN UTY	6.65e-05	196	116	7	5767_DN
Drug	Trimipramine maleate salt [521-78-8]; Down 200; 9.8uM; PC3; HT_HG-U133A	KANSL1L RHBDF2 ZNF268 CLCN4 RETREG1 SLITRK5 DHX34	6.65e-05	196	116	7	4083_DN
Drug	Flavoxate hydrochloride [3717-88-2]; Down 200; 9.4uM; HL60; HT_HG-U133A	RELB PPP1R15A SLC3A1 CLCN5 DHX34 UTRN HCFC1	6.65e-05	196	116	7	2373_DN
Drug	Testosterone propionate [57-85-2]; Down 200; 11.6uM; MCF7; HT_HG-U133A	POMT2 PHF8 SLC3A1 TCHH CTDP1 MORC3 UTRN	6.65e-05	196	116	7	5636_DN
Drug	Paromomycin sulfate [1263-89-4]; Down 200; 5.6uM; MCF7; HT_HG-U133A	POMT2 DISC1 MDM2 NF1 RETREG1 USP48 UTRN	6.65e-05	196	116	7	4420_DN
Drug	Berberine chloride [633-65-8]; Down 200; 10.8uM; MCF7; HT_HG-U133A	POMT2 DOK1 KANSL1L CLCN5 SLC22A4 DHX34 UTY	6.65e-05	196	116	7	2770_DN
Drug	Maprotiline hydrochloride [10347-81-6]; Up 200; 12.8uM; PC3; HT_HG-U133A	KANSL1L ZNF268 RELB LRRK1 PPP1R15A CLCN4 SYNJ1	6.65e-05	196	116	7	6676_UP
Drug	Meprylcaine hydrochloride [956-03-6]; Down 200; 14.8uM; PC3; HT_HG-U133A	LRRK1 MDM2 NF1 SLC22A4 RETREG1 TAF1 UTY	6.65e-05	196	116	7	5723_DN
Drug	Memantine Hydrochloride [41100-52-1]; Down 200; 18.6uM; MCF7; HT_HG-U133A	POMT2 PDE3B TEP1 NF1 DHX34 HCFC1 IL6ST	6.87e-05	197	116	7	4135_DN
Drug	Clopamide [636-54-4]; Down 200; 11.6uM; MCF7; HT_HG-U133A	PHF8 TEP1 NF1 SYNJ1 RETREG1 UTRN IL6ST	6.87e-05	197	116	7	5402_DN
Drug	Clidinium bromide [3485-62-9]; Down 200; 9.2uM; HL60; HT_HG-U133A	RHBDF1 RHBDF2 PPP1R15A CLCN4 SYNJ1 CTDP1 FBXW7	6.87e-05	197	116	7	2734_DN
Drug	Methyldopate hydrochloride [2508-79-4]; Down 200; 14.6uM; MCF7; HT_HG-U133A	PPP1R15A MDM2 TCHH CTDP1 EIF2AK1 USP48 UTRN	6.87e-05	197	116	7	4986_DN
Drug	Cortisone [53-06-5]; Down 200; 11uM; MCF7; HT_HG-U133A	SATB2 MDM2 NF1 MAGED2 RETREG1 CDYL DHX34	6.87e-05	197	116	7	7458_DN
Drug	Vigabatrin [60643-86-9]; Up 200; 31uM; PC3; HT_HG-U133A	WNT3 RELB NF1 SYNJ1 UTY HCFC1 IL6ST	6.87e-05	197	116	7	6314_UP
Drug	Ornidazole [16773-42-5]; Down 200; 18.2uM; PC3; HT_HG-U133A	POMT2 LRRK1 TEP1 SLC3A1 NF1 SYNJ1 HCFC1	7.09e-05	198	116	7	5064_DN
Drug	Androsterone [53-41-8]; Up 200; 13.8uM; MCF7; HT_HG-U133A	POMT2 DOK1 KANSL1L MDM2 BCO1 HCFC1 FBXW7	7.09e-05	198	116	7	2650_UP
Drug	Halcinonide [3093-35-4]; Down 200; 8.8uM; PC3; HT_HG-U133A	POMT2 RELB MDM2 DNAH7 NF1 RETREG1 CDYL	7.09e-05	198	116	7	3680_DN
Drug	Benzamil hydrochloride [2898-76-2]; Down 200; 11.2uM; PC3; HT_HG-U133A	DISC1 PHF8 MDM2 SLC3A1 NF1 SLITRK5 DHX34	7.09e-05	198	116	7	3738_DN
Drug	Epirizole [18694-40-1]; Down 200; 17uM; MCF7; HT_HG-U133A	KANSL1L DISC1 DUS4L NF1 TAF1 USP48 DHX34	7.09e-05	198	116	7	5995_DN
Drug	Nomegestrol acetate [58652-20-3]; Up 200; 10.8uM; MCF7; HT_HG-U133A	DOK1 CYP26B1 OBSL1 CTDP1 TAF1 DHX34 UTRN	7.09e-05	198	116	7	6525_UP
Drug	Enalapril maleate [76095-16-4]; Up 200; 8.2uM; MCF7; HT_HG-U133A	USP24 RELB PHF8 TAF1 DHX34 HCFC1 TTC33	7.09e-05	198	116	7	7428_UP
Drug	Propoxycaine hydrochloride [550-83-4]; Up 200; 12uM; MCF7; HT_HG-U133A	DISC1 OBSL1 RELB MDM2 TCHH NF1 UTRN	7.09e-05	198	116	7	3583_UP
Drug	Antipyrine [60-80-0]; Down 200; 21.2uM; MCF7; HT_HG-U133A	DUS4L HAUS5 NF1 CLCN5 CTDP1 UTRN FBXW7	7.32e-05	199	116	7	1489_DN
Drug	Nafronyl oxalate [3200-06-4]; Up 200; 8.4uM; PC3; HT_HG-U133A	HAUS5 MDM2 ACOX3 NF1 CLCN4 UTY IL6ST	7.32e-05	199	116	7	6687_UP
Drug	Isopropamide iodide [71-81-8]; Up 200; 8.4uM; PC3; HT_HG-U133A	USP24 RELB CLCN4 CTDP1 CDYL UTRN IL6ST	7.32e-05	199	116	7	7133_UP
Drug	Isoxicam [34552-84-6]; Up 200; 12uM; HL60; HT_HG-U133A	HAUS5 RELB LRRK1 NF1 SYNJ1 MAGED2 FBXW7	7.32e-05	199	116	7	1862_UP
Drug	Azlocillin sodium salt [37091-65-9]; Down 200; 8.2uM; PC3; HT_HG-U133A	POMT2 ACOX3 NF1 CLCN5 UTRN UTY RUSF1	7.32e-05	199	116	7	5788_DN
Drug	Lorglumide sodium salt [97964-56-2]; Down 200; 8.4uM; HL60; HT_HG-U133A	HAUS5 IRF7 LRRK1 PHF8 MDM2 MAGED2 UTRN	7.32e-05	199	116	7	3079_DN
Drug	Methyldopate hydrochloride [2508-79-4]; Down 200; 14.6uM; HL60; HT_HG-U133A	DOK1 PDE3B DUS4L HAUS5 RELB NF1 TRMT12	7.32e-05	199	116	7	2940_DN
Drug	Xylometazoline hydrochloride [1218-35-5]; Up 200; 14.2uM; MCF7; HT_HG-U133A	PPP1R15A MDM2 TUBGCP5 NF1 DHX34 IL6ST FBXW7	7.32e-05	199	116	7	7020_UP
Drug	Griseofulvin [126-07-8]; Down 200; 11.2uM; PC3; HT_HG-U133A	INPPL1 DUS4L HAUS5 LRRK1 TUBGCP5 RUSF1 IL6ST	7.32e-05	199	116	7	3664_DN
Drug	Harmane hydrochloride [21655-84-5]; Down 200; 18.2uM; MCF7; HT_HG-U133A	PDE3B HAUS5 CDYL DHX34 RUSF1 IL6ST TTC33	7.32e-05	199	116	7	2806_DN
Drug	Lysergol [602-85-7]; Down 200; 15.8uM; HL60; HT_HG-U133A	KANSL1L RHBDF2 HAUS5 LRRK1 NF1 CLCN4 CDYL	7.32e-05	199	116	7	1325_DN
Drug	beta- Belladonnine dichloroethylate [191355-47-2]; Down 200; 6uM; MCF7; HT_HG-U133A	DOK1 TEP1 NF1 SYNJ1 UTY RUSF1 IL6ST	7.32e-05	199	116	7	2819_DN
Drug	Lycorine hydrochloride [2188-68-3]; Down 200; 12.4uM; MCF7; HT_HG-U133A	POMT2 IRF7 TEP1 BCO1 DHX34 UTY IL6ST	7.32e-05	199	116	7	3891_DN
Drug	estradiol, USP; Up 200; 0.1uM; MCF7; HT_HG-U133A_EA	KANSL1L MDM2 TEP1 CLCN5 TAF1 UTRN IL6ST	7.32e-05	199	116	7	988_UP
Drug	Telenzepine dihydrochloride [147416-96-4]; Down 200; 9uM; PC3; HT_HG-U133A	CYP26B1 USP24 LRRK1 SLC3A1 CDYL RUSF1 IL6ST	7.32e-05	199	116	7	5096_DN
Drug	Methantheline bromide [53-46-3]; Up 200; 9.6uM; MCF7; HT_HG-U133A	POMT2 HAUS5 RELB MDM2 NF1 UTRN IL6ST	7.32e-05	199	116	7	3560_UP
Drug	Tolmetin sodium salt dihydrate [64490-92-2]; Down 200; 12.6uM; PC3; HT_HG-U133A	KANSL1L ZNF268 USP24 MDM2 RETREG1 DHX34 IL6ST	7.55e-05	200	116	7	4088_DN
Drug	Prilocaine hydrochloride [1786-81-8]; Up 200; 15.6uM; MCF7; HT_HG-U133A	POMT2 RELB PHF8 MDM2 BCO1 TCHH DHX34	7.55e-05	200	116	7	2314_UP
Drug	Todralazine hydrochloride [3778-76-5]; Down 200; 14.8uM; MCF7; HT_HG-U133A	RHBDF2 DISC1 INPPL1 TRMT1 PPP1R15A SLC22A4 HCFC1	7.55e-05	200	116	7	5512_DN
Drug	Loxapine succinate [27833-64-3]; Up 200; 9uM; HL60; HG-U133A	IRF7 LRRK1 MED13L NF1 SLC22A4 MORC3 UTRN	7.55e-05	200	116	7	2016_UP
Drug	Saquinavir mesylate [149845-06-7]; Up 200; 5.2uM; MCF7; HT_HG-U133A	POMT2 DOK1 TRPC7 OBSL1 LRRK1 NF1 HCFC1	7.55e-05	200	116	7	3549_UP
Drug	Dithioerythritol	SLC22A4 SLC22A5	1.53e-04	4	116	2	ctd:D004226
Drug	Naphthalimides	XIAP TEP1	1.53e-04	4	116	2	ctd:D053644
Drug	3-((4-chlorobenzyl)oxy)-N-((1S)-1-phenylethyl)-2-thiophenecarboxamide	INPPL1 G6PC1	2.55e-04	5	116	2	ctd:C546412
Drug	AC1NV8Y2	SLC22A4 SLC22A5	2.55e-04	5	116	2	CID005473939
Drug	resveratrol; Up 200; 10uM; MCF7; HT_HG-U133A_EA	POMT2 RHBDF2 IRF7 PPP1R15A MDM2 RUSF1	3.25e-04	180	116	6	958_UP
Drug	ICI 182,780; Down 200; 0.01uM; MCF7; HT_HG-U133A	PDE3B MED13L NF1 SLC22A5 RUSF1 TTC33	3.44e-04	182	116	6	1663_DN
Drug	Digoxin [20830-75-5]; Down 200; 5.2uM; HL60; HT_HG-U133A	RHBDF2 DUS4L NF1 SLITRK5 EIF2AK1 RUSF1	3.55e-04	183	116	6	2423_DN
Drug	Allopurinol	PYCARD SLC22A4 SLC22A5 NOS3	3.61e-04	66	116	4	ctd:D000493
Drug	15d-PGJ2; Down 200; 10uM; HL60; HT_HG-U133A	RHBDF2 HAUS5 OBSL1 ACOX3 MAGED2 HCFC1	3.65e-04	184	116	6	2691_DN
Drug	Rolitetracycline [751-97-3]; Down 200; 7.6uM; MCF7; HT_HG-U133A	PDE3B TEP1 NF1 RETREG1 RUSF1 IL6ST	3.76e-04	185	116	6	3369_DN
Drug	3-ISOBUTYL-1-METHYLXANTHINE	PDE3B PDE7A	3.81e-04	6	116	2	DB07954
Drug	Metixene hydrochloride [1553-34-0]; Up 200; 11.6uM; PC3; HT_HG-U133A	KANSL1L WNT3 RELB PPP1R15A PHF8 MDM2	3.87e-04	186	116	6	6672_UP
Drug	Isotretinoin [4759-48-2]; Up 200; 13.4uM; MCF7; HT_HG-U133A	CYP26B1 HAUS5 SLC22A4 SLC22A5 USP48 UTRN	4.21e-04	189	116	6	7438_UP
Drug	Lorglumide sodium salt [97964-56-2]; Down 200; 8.4uM; MCF7; HT_HG-U133A	POMT2 PDE3B MDM2 CLCN5 SYNJ1 DHX34	4.21e-04	189	116	6	5254_DN
Drug	Flavoxate hydrochloride [3717-88-2]; Down 200; 9.4uM; MCF7; HT_HG-U133A	SATB2 TRMT1 MED13L TUBGCP5 MORC3 IL6ST	4.33e-04	190	116	6	7405_DN
Drug	Pinacidil [85371-64-8]; Down 200; 16.4uM; MCF7; HT_HG-U133A	DISC1 PPP1R15A TEP1 NF1 CLCN5 DHX34	4.45e-04	191	116	6	5456_DN
Drug	Trimethadione [127-48-0]; Up 200; 28uM; MCF7; HT_HG-U133A	PHF8 BCO1 TAF1 MORC3 UTRN IL6ST	4.58e-04	192	116	6	2846_UP
Drug	thioridazine hydrochloride; Down 200; 10uM; HL60; HT_HG-U133A	DOK1 ZNF268 HAUS5 MDM2 SLC22A4 SLITRK5	4.70e-04	193	116	6	2690_DN
Drug	Rapamycin; Down 200; 0.1uM; MCF7; HT_HG-U133A	SATB2 RHBDF2 INPPL1 ACOX3 NF1 HCFC1	4.70e-04	193	116	6	6981_DN
Drug	Fluticasone propionate [80474-14-2]; Down 200; 8uM; MCF7; HT_HG-U133A	DOK1 DISC1 MDM2 NF1 HCFC1 IL6ST	4.70e-04	193	116	6	4129_DN
Disease	osteopetrosis (implicated_via_orthology)	LRRK1 CLCN4 CLCN5	2.00e-06	7	115	3	DOID:13533 (implicated_via_orthology)
Disease	Dent disease (implicated_via_orthology)	CLCN4 CLCN5	4.51e-05	3	115	2	DOID:0050699 (implicated_via_orthology)
Disease	Cobblestone Lissencephaly	POMT2 TMTC3	4.51e-05	3	115	2	C0431376
Disease	Recurrent infections	RELB IL6ST	1.49e-04	5	115	2	C0239998
Disease	Liposarcoma, well differentiated	MDM2 NF1	2.24e-04	6	115	2	C1370889
Disease	Coxsackievirus Infections	SLC22A4 SLC22A5	2.24e-04	6	115	2	C0010246
Disease	Liposarcoma, Dedifferentiated	MDM2 NF1	2.24e-04	6	115	2	C0205824
Disease	Myocarditis	SLC22A4 SLC22A5	2.24e-04	6	115	2	C0027059
Disease	Carditis	SLC22A4 SLC22A5	2.24e-04	6	115	2	C0869523
Disease	Cleft Palate	SATB2 MED13L CBFB NOS3	2.89e-04	81	115	4	C0008925
Disease	Glioma	MDM2 NF1 CLCN5 FBXW7	3.80e-04	87	115	4	C0017638
Disease	acetylcarnitine measurement	SLC22A4 SLC22A5	4.15e-04	8	115	2	EFO_0021038
Disease	butyrylcarnitine measurement	SLC22A4 SLC22A5	4.15e-04	8	115	2	EFO_0020010
Disease	nervonoylcarnitine (C24:1) measurement	SLC22A4 SLC22A5	5.32e-04	9	115	2	EFO_0800549
Disease	Cleft palate, isolated	SATB2 CBFB NOS3	5.93e-04	42	115	3	C1837218
Disease	lignoceroylcarnitine (C24) measurement	SLC22A4 SLC22A5	8.09e-04	11	115	2	EFO_0800541
Disease	tryptophan betaine measurement	SLC22A4 SLC22A5	9.69e-04	12	115	2	EFO_0021017
Disease	hexanoylcarnitine measurement	SLC22A4 SLC22A5	9.69e-04	12	115	2	EFO_0021040
Disease	homostachydrine measurement	SLC22A4 SLC22A5	1.14e-03	13	115	2	EFO_0021164
Disease	dihomo-linolenoylcarnitine (C20:3n3 or 6) measurement	SLC22A4 SLC22A5	1.14e-03	13	115	2	EFO_0800547
Disease	cerotoylcarnitine (C26) measurement	SLC22A4 SLC22A5	1.14e-03	13	115	2	EFO_0800542
Disease	Profound Mental Retardation	DISC1 TRMT1 MED13L NF1	2.18e-03	139	115	4	C0020796
Disease	Mental Retardation, Psychosocial	DISC1 TRMT1 MED13L NF1	2.18e-03	139	115	4	C0025363
Disease	Mental deficiency	DISC1 TRMT1 MED13L NF1	2.18e-03	139	115	4	C0917816
Disease	cardiomyopathy (is_implicated_in)	SLC22A5 NOS3	2.47e-03	19	115	2	DOID:0050700 (is_implicated_in)
Disease	oleoylcarnitine measurement	SLC22A4 SLC22A5	2.47e-03	19	115	2	EFO_0021043
Disease	Malignant Glioma	NF1 CLCN5 FBXW7	2.61e-03	70	115	3	C0555198
Disease	mixed gliomas	NF1 CLCN5 FBXW7	2.61e-03	70	115	3	C0259783
Disease	Sarcoma	MDM2 NF1	3.01e-03	21	115	2	C1261473
Disease	Metabolic Syndrome X	INPPL1 NOS3	3.01e-03	21	115	2	C0524620
Disease	Nephritis, Tubulointerstitial	SLC3A1 CLCN5	3.01e-03	21	115	2	C0041349
Disease	wellbeing measurement, alcohol consumption measurement	RELB DST CPNE4	3.06e-03	74	115	3	EFO_0007869, EFO_0007878
Disease	Malignant neoplasm of breast	OBSCN MDM2 CBFB NF1 MAGED2 FKBPL ADGRF4 G6PC1 NOS3 RUSF1 FBXW7	3.20e-03	1074	115	11	C0006142
Disease	Splenomegaly	XIAP EIF2AK1	3.31e-03	22	115	2	C0038002

Protein segments in the cluster

Peptide	Gene	Start	Entry
WTVGICRDNVERKWE	BTN2A3P	366	Q96KV6
TPAWNWTCKDLLLQA	PYCARD	166	Q9ULZ3
LWSCLERWDKVEEQL	CTDP1	711	Q9Y5B0
WLAESKTKLQWLCEE	CEP128	866	Q6ZU80
LQESKVLERASWWPE	ACOX3	671	O15254
EVILELGWSQPCDVW	CLK2	351	P49760
PEACWLNWDNTKALL	ADGRF4	546	Q8IZF3
EADWILEQLCQDVPW	ALKBH3	101	Q96Q83
WDQTVKLWDPRTPCN	BUB3	116	O43684
NRCAAWEGKELITWR	ERVV-2	181	B6SEH9
TTFEDRDKCPLWQKW	CLCN4	121	P51793
TLKICSWNVDGLRAW	APEX1	61	P27695
WDTLLRKWEPVLRDC	DISC1	326	Q9NRI5
WCWTEEKADIVSRPD	ARMCX4	1746	Q5H9R4
REVEVTACLVWKDWP	RELB	176	Q01201
KQLLPVCDTWEDTVW	NUP107	436	P57740
LETQLWACAFEPAWE	LRWD1	291	Q9UFC0
RCLILWDDILPNSKW	ANAPC1	1411	Q9H1A4
ELCRPWAEVRWTKDG	OBSL1	921	O75147
WENLPLWTLEEALRK	TENT4B	186	Q8NDF8
DLWTLDIDTLTWNKP	HCFC1	231	P51610
RWTWLQAQISDLECK	KANSL1L	381	A0AUZ9
WDPAWTLIGQCVDLL	KIAA0100	1101	Q14667
KCDLVPTWATKRWVA	GNL2	256	Q13823
VWRRDVKPDCKELWI	MED13L	71	Q71F56
RPTSCWQLDWDELET	M1AP	331	Q8TC57
CNWDEADIGPWAKAR	MAGED2	516	Q9UNF1
PWVDLDWLIDISCQI	LRRK1	266	Q38SD2
LLDWRRKLCEEGQDW	MYO16	1801	Q9Y6X6
LCPISWVESWNEQIK	COX6B2	66	Q6YFQ2
KEQVETLWPWIDKCQ	DST	4961	Q03001
TLWPWIDKCQNNLEE	DST	4966	Q03001
TIWEFCQRPWKLVEA	ENTPD8	376	Q5MY95
QLWQLRWAATRDKSC	CYP26B1	31	Q9NR63
NRCAAWEGKELITWR	ERVV-1	181	B6SEH8
DTTPWILCKGDWSRL	ISM2	526	Q6H9L7
QVEEDDRPELPWWKC	IPO7	246	O95373
PDQTWVQCDACLKWR	MORC3	406	Q14149
CISREQMILWDWDLK	PDE3B	321	Q13370
VCVIWKGWIDLQRLD	CBFB	106	Q13951
PCRTWELSKQWSEKV	PDE7A	366	Q13946
PTWLQDKSWEEICRA	DNAH12	2386	Q6ZR08
DPCISWKDEPDDRSW	TUBGCP5	201	Q96RT8
NVPLCKEDCERWWED	FOLR3	131	P41439
QWLDEARTCFRVPWK	IRF7	31	Q92985
DLLLLQDQRSLWCWD	HAUS5	521	O94927
EEWKWFRCPTLLEVL	NOS3	901	P29474
QKPDLSDWEWCRSKS	GPR149	521	Q86SP6
ATLWCELSKAAPVEW	OBSCN	3731	Q5VST9
CDLLWSDPDKDVQGW	PPP1CB	201	P62140
GWRTCLVVPELSWEL	NT5DC4	331	Q86YG4
WREETWGELIEKCLE	FKBPL	151	Q9UIM3
EWCVLSDKAPCITDW	IL6ST	456	P40189
REPKDAWWCQARVKE	DOK1	381	Q99704
ILPLCDVVWANEKAW	CDYL	456	Q9Y232
LCELSLWDWIVERNK	EIF2AK1	386	Q9BQI3
GRVEELKLPWWRESS	FAM83C	21	Q9BQN1
GVDLLWTLEKAQRWC	G6PC1	231	P35575
WTLEKAQRWCEQPEW	G6PC1	236	P35575
DPDRRLKCIVWDWDS	CPNE4	221	Q96A23
EERDKCPEWNSWSQL	CLCN5	181	P51795
TWLPQKSWDEICRLD	DNAH7	3321	Q8WXX0
WRILAEDNLLWREKC	FBXW7	311	Q969H0
RWDEICQALLAEWDP	DUXB	326	A0A1W2PPF3
PEVWEDWLKDVCEKN	MDH1B	41	Q5I0G3
LVWQPWEDLESSREK	MIDEAS	751	Q6PJG2
EWSPWNCILLTKDEA	IQUB	706	Q8NA54
TPLKCIWDWVDIALE	DUS4L	256	O95620
EKWDWNCPETRRLLE	DHX34	26	Q14147
EWNLVCEDNWKVPLT	SLC22A4	131	Q9H015
EWNLVCEDDWKAPLT	SLC22A5	131	O76082
RPQLKSWWCQPSDEE	PPP1R15A	296	O75807
ALPEWISCLIQKAQW	RNF180	66	Q86T96
LLCVWLPWGEQAAES	OTOG	11	Q6ZRI0
LPRRLAWCSIDWEQV	MOS	46	P00540
WKQLCLELRAAWGEL	GDF6	226	Q6KF10
EVDEWRATWLLSPEK	RUSF1	451	Q96GQ5
NPWDCTCDLVALKLW	SLITRK4	531	Q8IW52
WQELLEEQCLLKAWL	UTRN	531	P46939
DENWDPTGTKKIWRC	UTY	956	O14607
CAWRGKRLPTEEEWE	SUMF2	156	Q8NBJ7
PASALWDIMRCWEKE	TRMT1	491	Q9NXH9
VLPKWGWEQLEVTCT	POMT2	491	Q9UKY4
SEKCRTPAWTDRVLW	SYNJ1	796	O43426
KRLCTERQKSWWDAV	RGPD2	521	P0DJD1
VLWLGCRADELLSWK	RETREG1	76	Q9H6L5
WWVLKSDFRLPTEEE	TAF1	861	P21675
LAKELWSSCTTPDEW	SMG1	2296	Q96Q15
RCWALRENWLPEDKG	MDM2	321	Q00987
WVQCDECLKWRKLPG	MORC4	426	Q8TE76
EECSSTLAVWVKWPI	RHBDF1	516	Q96CC6
WLCELLRWKENPSPE	SATB2	516	Q9UPW6
VRTNVPSWCDRILWK	INPPL1	681	O15357
SPLVAVEWWRICLDE	SHPRH	806	Q149N8
AIIALSPKCLDWWQE	SLC3A1	106	Q07837
LTKSSLKWREDDCWP	BCO1	441	Q9HAY6
PLCDIVWASEKAWFQ	CDYL2	366	Q8N8U2
LQPWCPLDLRLEWVD	NCAPD3	11	P42695
LTWVTDERVCLQWLK	FAP	296	Q12884
RDWCPWVNITLGKES	ZC3HC1	426	Q86WB0
GSWTWLPKLCSLREL	TMEM240	126	Q5SV17
KLKNWEPCDRAWSEH	XIAP	206	P98170
TWEEWQLLDPAQKCL	ZNF268	91	Q14587
ILWNLAKCSPEGEWT	TEP1	2486	Q99973
TGWLWRLCEDIDAEP	SPATA12	141	Q7Z6I5
PWNCSCELISLKDWL	SLITRK5	236	O94991
LQPTDTCDIWDKIWN	SULT1C4	26	O75897
EVKTCWWAQPDFRAI	WNT3	216	P56703
RIITNSALDWWPKID	NF1	416	P21359
PTCKWLDQWTELAQR	NF1	2221	P21359
SAPNECLWTDWLLER	TIMP4	171	Q99727
ESEWIINTPLWPCDR	TOPAZ1	1436	Q8N9V7
LGWNRAKEIWECLVT	USP24	726	Q9UPU5
VRKLSWVENLWPEEC	PHF8	246	Q9UPP1
PCCEKSLLWGDLIWL	SLX1A	236	Q9BQ83
KWSAELEADLPRSWQ	TRMT12	121	Q53H54
AWLLLNPSELCCDWT	TMTC3	291	Q6ZXV5
IWPDDITKWPICTEQ	RHBDF2	566	Q6PJF5
EDSKLIALIWPSEWQ	USP48	791	Q86UV5
IPKWQWQLESEADAR	TCHH	701	Q07283
CQLENWDEQWILDLP	ZNF789	61	Q5FWF6
IWSECKEIWEEGPRE	TRPC7	451	Q9HCX4
PEIWKEDLSWARTLQ	TTC33	161	Q6PID6