Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionretromer complex binding

WASHC2C WASHC2A

9.75e-0510302GO:1905394
GeneOntologyMolecularFunctionmyosin II binding

STXBP5L STXBP5

1.68e-0413302GO:0045159
GeneOntologyMolecularFunctionphosphatidylinositol-4,5-bisphosphate binding

AMER1 WASHC2C WASHC2A

3.86e-0495303GO:0005546
GeneOntologyMolecularFunctionphosphatidylinositol-5-phosphate binding

WASHC2C WASHC2A

5.41e-0423302GO:0010314
GeneOntologyMolecularFunctionphosphatidylinositol bisphosphate binding

AMER1 WASHC2C WASHC2A

7.82e-04121303GO:1902936
GeneOntologyMolecularFunctionphosphatidylinositol-3,5-bisphosphate binding

WASHC2C WASHC2A

9.88e-0431302GO:0080025
GeneOntologyMolecularFunctionphosphatidylinositol-3,4-bisphosphate binding

WASHC2C WASHC2A

1.26e-0335302GO:0043325
GeneOntologyMolecularFunctionphosphatidylinositol-4-phosphate binding

WASHC2C WASHC2A

1.33e-0336302GO:0070273
GeneOntologyMolecularFunctionstructural constituent of skin epidermis

KRT72 KRT77

1.90e-0343302GO:0030280
GeneOntologyMolecularFunctionphosphatidylinositol-3-phosphate binding

WASHC2C WASHC2A

2.36e-0348302GO:0032266
GeneOntologyMolecularFunctionphosphatidylinositol-3,4,5-trisphosphate binding

WASHC2C WASHC2A

2.46e-0349302GO:0005547
GeneOntologyMolecularFunctionphosphatidylinositol phosphate binding

AMER1 WASHC2C WASHC2A

3.25e-03199303GO:1901981
GeneOntologyBiologicalProcessintracellular transport

TIMM23 NUP50 ALYREF TIMM13 WASHC2C HEATR5B WASHC2A DNAJC6 ANKRD54 NUP54

3.06e-0514963010GO:0046907
GeneOntologyCellularComponentWASH complex

WASHC2C WASHC2A

2.07e-0415302GO:0071203
GeneOntologyCellularComponentextrinsic component of presynaptic membrane

DNAJC6 STXBP5

3.00e-0418302GO:0098888
GeneOntologyCellularComponentextrinsic component of plasma membrane

CDH22 DNAJC6 STXBP5

9.82e-04137303GO:0019897
GeneOntologyCellularComponentextrinsic component of synaptic membrane

DNAJC6 STXBP5

1.15e-0335302GO:0099243
GeneOntologyCellularComponentneuronal dense core vesicle

STXBP5L STXBP5

1.22e-0336302GO:0098992
GeneOntologyCellularComponentSNARE complex

STXBP5L STXBP5

2.43e-0351302GO:0031201
GeneOntologyCellularComponentdense core granule

STXBP5L STXBP5

2.92e-0356302GO:0031045
DomainLgl_C

STXBP5L STXBP5

2.49e-062302PF08596
DomainFAM21

WASHC2C WASHC2A

2.49e-062302IPR027308
DomainLgl_C_dom

STXBP5L STXBP5

2.49e-062302IPR013905
DomainFAM21/CAPZIP

WASHC2C WASHC2A

7.48e-063302IPR029341
DomainCAP-ZIP_m

WASHC2C WASHC2A

7.48e-063302PF15255
DomainLLGL

STXBP5L STXBP5

1.49e-054302PF08366
DomainLethal2_giant

STXBP5L STXBP5

1.49e-054302IPR000664
DomainLLGL2

STXBP5L STXBP5

1.49e-054302IPR013577
DomainHaem_d1

STXBP5L STXBP5

3.73e-056302IPR011048
DomainV_SNARE

STXBP5L STXBP5

1.63e-0412302PS50892
DomainSynaptobrevin

STXBP5L STXBP5

1.92e-0413302IPR001388
DomainKeratin_2_head

KRT72 KRT77

6.73e-0424302IPR032444
DomainKeratin_2_head

KRT72 KRT77

6.73e-0424302PF16208
DomainKeratin_II

KRT72 KRT77

7.91e-0426302IPR003054
DomainMAGE

MAGED2 TRO

1.36e-0334302SM01373
DomainMAGE

MAGED2 TRO

1.52e-0336302PS50838
DomainMHD_dom

MAGED2 TRO

1.52e-0336302IPR002190
DomainMAGE

MAGED2 TRO

1.52e-0336302PF01454
DomainIntermediate_filament_CS

KRT72 KRT77

4.58e-0363302IPR018039
DomainFilament

KRT72 KRT77

5.79e-0371302SM01391
DomainIF

KRT72 KRT77

5.95e-0372302PS00226
DomainFilament

KRT72 KRT77

6.11e-0373302PF00038
DomainIF

KRT72 KRT77

6.60e-0376302IPR001664
PathwayREACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA

NUP50 ALYREF NUP54

1.69e-0536203M26974
PathwayREACTOME_TRANSPORT_OF_THE_SLBP_DEPENDANT_MATURE_MRNA

NUP50 ALYREF NUP54

2.91e-0543203MM14609
PathwayREACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS

NUP50 ALYREF NUP54

2.91e-0543203M26975
PathwayREACTOME_TRANSPORT_OF_MATURE_MRNAS_DERIVED_FROM_INTRONLESS_TRANSCRIPTS

NUP50 ALYREF NUP54

4.59e-0550203MM14610
PathwayREACTOME_TRNA_PROCESSING_IN_THE_NUCLEUS

NUP50 DDX1 NUP54

7.55e-0559203M27606
PathwayREACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM

NUP50 ALYREF NUP54

2.16e-0484203M725
PathwayREACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM

NUP50 ALYREF NUP54

2.32e-0486203MM15413
PathwayREACTOME_TRNA_PROCESSING

NUP50 DDX1 NUP54

4.91e-04111203M27684
PathwayREACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA

RBM5 NUP50 ALYREF NUP54

5.51e-04277204MM15414
PathwayREACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA

RBM5 NUP50 ALYREF NUP54

5.98e-04283204M13087
PathwayKEGG_MEDICUS_REFERENCE_NUCLEAR_EXPORT_OF_MRNA

ALYREF NUP54

8.12e-0430202M47752
PathwayREACTOME_REGULATION_OF_GLUCOKINASE_BY_GLUCOKINASE_REGULATORY_PROTEIN

NUP50 NUP54

9.25e-0432202M29579
PathwayREACTOME_EXPORT_OF_VIRAL_RIBONUCLEOPROTEINS_FROM_NUCLEUS

NUP50 NUP54

9.83e-0433202M27016
PathwayREACTOME_NUCLEAR_IMPORT_OF_REV_PROTEIN

NUP50 NUP54

1.04e-0334202M27041
PathwayREACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS

NUP50 NUP54

1.11e-0335202M27320
PathwayREACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY

NUP50 NUP54

1.17e-0336202M27245
PathwayREACTOME_INTERACTIONS_OF_VPR_WITH_HOST_CELLULAR_PROTEINS

NUP50 NUP54

1.24e-0337202M1029
PathwayREACTOME_INTERACTIONS_OF_REV_WITH_HOST_CELLULAR_PROTEINS

NUP50 NUP54

1.24e-0337202M27038
PathwayREACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS

NUP50 NUP54

1.37e-0339202M27238
PathwayREACTOME_NUCLEAR_PORE_COMPLEX_NPC_DISASSEMBLY

NUP50 NUP54

1.44e-0340202MM14945
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS

NUP50 NUP54

1.52e-0341202MM15200
PathwayREACTOME_NS1_MEDIATED_EFFECTS_ON_HOST_PATHWAYS

NUP50 NUP54

1.52e-0341202M29574
PathwayREACTOME_SUMOYLATION_OF_SUMOYLATION_PROTEINS

NUP50 NUP54

1.59e-0342202MM15039
PathwayREACTOME_VIRAL_MESSENGER_RNA_SYNTHESIS

NUP50 NUP54

1.75e-0344202M109
PathwayREACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS

NUP50 NUP54

1.91e-0346202M27397
PathwayREACTOME_SUMOYLATION_OF_UBIQUITINYLATION_PROTEINS

NUP50 NUP54

1.99e-0347202MM14939
PathwayREACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS

NUP50 NUP54

1.99e-0347202M27395
PathwayREACTOME_GENE_SILENCING_BY_RNA

NUP50 NUP54

2.16e-0349202MM14837
PathwayREACTOME_SUMOYLATION_OF_DNA_REPLICATION_PROTEINS

NUP50 NUP54

2.34e-0351202MM15151
PathwayREACTOME_NUCLEAR_ENVELOPE_BREAKDOWN

NUP50 NUP54

2.52e-0353202M27212
PathwayREACTOME_SNRNP_ASSEMBLY

NUP50 NUP54

2.62e-0354202M29594
PathwayREACTOME_NUCLEAR_ENVELOPE_BREAKDOWN

NUP50 NUP54

2.71e-0355202MM14917
PathwayREACTOME_METABOLISM_OF_RNA

RBM5 NUP50 ALYREF DDX1 NUP54

2.87e-03724205M16843
PathwayREACTOME_SUMOYLATION_OF_RNA_BINDING_PROTEINS

NUP50 NUP54

3.01e-0358202MM15149
PathwayREACTOME_SNRNP_ASSEMBLY

NUP50 NUP54

3.01e-0358202MM14736
PathwayREACTOME_MITOCHONDRIAL_PROTEIN_IMPORT

TIMM23 TIMM13

3.77e-0365202M590
PathwayREACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS

NUP50 NUP54

3.77e-0365202MM15147
PathwayREACTOME_SUMOYLATION_OF_CHROMATIN_ORGANIZATION_PROTEINS

NUP50 NUP54

4.48e-0371202M27394
PathwayREACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE

NUP50 NUP54

4.73e-0373202MM14948
PathwayREACTOME_ISG15_ANTIVIRAL_MECHANISM

NUP50 NUP54

4.86e-0374202M48006
PathwayREACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS

NUP50 NUP54

5.25e-0377202M27226
PathwayREACTOME_GLUCOSE_METABOLISM

NUP50 NUP54

5.93e-0382202MM15394
PathwayREACTOME_REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE

NUP50 NUP54

5.93e-0382202M27250
PathwayREACTOME_SUMOYLATION_OF_DNA_DAMAGE_RESPONSE_AND_REPAIR_PROTEINS

NUP50 NUP54

6.22e-0384202MM14929
PathwayREACTOME_GLUCOSE_METABOLISM

NUP50 NUP54

6.36e-0385202M1870
PathwayREACTOME_FORMATION_OF_THE_CORNIFIED_ENVELOPE

KRT72 KRT77

6.66e-0387202MM15351
PathwayREACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS

NUP50 NUP54

7.42e-0392202MM14951
PathwayREACTOME_SLC_TRANSPORTER_DISORDERS

NUP50 NUP54

8.54e-0399202M27474
PathwayREACTOME_CELLULAR_RESPONSE_TO_HEAT_STRESS

NUP50 NUP54

8.88e-03101202M27253
PathwayREACTOME_TRANSCRIPTIONAL_REGULATION_BY_SMALL_RNAS

NUP50 NUP54

9.74e-03106202M27458
PathwayREACTOME_METABOLISM_OF_RNA

RBM5 NUP50 ALYREF NUP54

9.78e-03612204MM15547
Pubmed

Control of HIV replication in astrocytes by a family of highly conserved host proteins with a common Rev-interacting domain (Risp).

WASHC2C WASHC2A

7.19e-07230220827171
Pubmed

Identification and characterization of human LLGL4 gene and mouse Llgl4 gene in silico.

STXBP5L STXBP5

7.19e-07230214767561
Pubmed

FAM21 is critical for TLR2/CLEC4E-mediated dendritic cell function against Candida albicans.

WASHC2C WASHC2A

7.19e-07230236717248
Pubmed

Identification of a novel Rev-interacting cellular protein.

WASHC2C WASHC2A

7.19e-07230215847701
Pubmed

Genomic screen for genes involved in mammalian craniofacial development.

MAGED2 TRO DDX1

1.16e-062430312533789
Pubmed

Tomosyn: a syntaxin-1-binding protein that forms a novel complex in the neurotransmitter release process.

STXBP5L STXBP5

2.16e-0633029620695
Pubmed

Comparative expression analysis of the MAGED genes during embryogenesis and brain development.

MAGED2 TRO

2.16e-06330215162511
Pubmed

Tomosyn associates with secretory vesicles in neurons through its N- and C-terminal domains.

STXBP5L STXBP5

2.16e-06330228746398
Pubmed

In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.

RBM5 KRT72 AMER1 MAGED2 YY1 TRO KRT77 DDX1 NUP54

2.29e-06144230935575683
Pubmed

Structural and functional analysis of tomosyn identifies domains important in exocytotic regulation.

STXBP5L STXBP5

4.31e-06430221330375
Pubmed

Two distinct genes drive expression of seven tomosyn isoforms in the mammalian brain, sharing a conserved structure with a unique variable domain.

STXBP5L STXBP5

7.18e-06530215659226
Pubmed

Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.

RBM5 TIMM23 NUP50 TIMM13 MAGED2 YY1 ANKRD54

1.03e-0591630732203420
Pubmed

Tomosyn-2 is required for normal motor performance in mice and sustains neurotransmission at motor endplates.

STXBP5L STXBP5

2.01e-05830224744148
Pubmed

A FAM21-containing WASH complex regulates retromer-dependent sorting.

WASHC2C WASHC2A

2.01e-05830219922874
Pubmed

Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

WASHC2C WASHC2A DNAJC6 STXBP5 TRO

2.40e-0540730512693553
Pubmed

Identification of new high affinity targets for Roquin based on structural conservation.

MEX3A DDX1

3.94e-051130230295819
Pubmed

Comparative Application of BioID and TurboID for Protein-Proximity Biotinylation.

NUP50 ALYREF TIMM13 DDX1 NUP54

4.16e-0545730532344865
Pubmed

Loss of strumpellin in the melanocytic lineage impairs the WASH Complex but does not affect coat colour.

WASHC2C WASHC2A

4.72e-051230227390154
Pubmed

The Arp2/3 activator WASH controls the fission of endosomes through a large multiprotein complex.

WASHC2C WASHC2A

4.72e-051230219922875
Pubmed

Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling.

WASHC2C WASHC2A

7.50e-051530228892079
Pubmed

Comprehensive analysis of keratin gene clusters in humans and rodents.

KRT72 KRT77

8.57e-051630215085952
Pubmed

An overview of the MAGE gene family with the identification of all human members of the family.

MAGED2 TRO

1.09e-041830211454705
Pubmed

Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia.

TIMM23 WASHC2C WASHC2A DNAJC6

1.12e-0429230412819125
Pubmed

COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A.

WASHC2C WASHC2A

1.22e-041930225355947
Pubmed

Genome-wide CRISPR Screen to Identify Genes that Suppress Transformation in the Presence of Endogenous KrasG12D.

WASHC2C WASHC2A

1.80e-042330231748650
Pubmed

LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.

ALYREF TIMM13 AMER1 MAGED2 NUP54

2.01e-0463930523443559
Pubmed

Nuclear import of hepatic glucokinase depends upon glucokinase regulatory protein, whereas export is due to a nuclear export signal sequence in glucokinase.

NUP50 NUP54

2.13e-042530210601273
Pubmed

Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.

OXR1 DNAJC6 STXBP5L STXBP5

2.17e-0434730417114649
Pubmed

A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.

ALYREF AMER1 HEATR5B MAGED2 WASHC2A ANKRD54

2.24e-04103830626673895
Pubmed

Docking of HIV-1 Vpr to the nuclear envelope is mediated by the interaction with the nucleoporin hCG1.

NUP50 NUP54

2.31e-042630212228227
Pubmed

SNX27-driven membrane localisation of OTULIN antagonises linear ubiquitination and NF-κB signalling activation.

RBM5 WASHC2C HEATR5B WASHC2A

3.01e-0437830434315543
Pubmed

The Structure Inventory of the Nuclear Pore Complex.

NUP50 NUP54

3.08e-043030227016207
Pubmed

Integrated structural analysis of the human nuclear pore complex scaffold.

NUP50 NUP54

3.08e-043030224315095
Pubmed

Nucleophosmin serves as a rate-limiting nuclear export chaperone for the Mammalian ribosome.

NUP50 DDX1

3.51e-043230218809582
Pubmed

The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation.

KRT72 ALYREF HEATR5B MAGED2 KRT77 DDX1

3.93e-04115330629845934
Pubmed

Peering through the pore: nuclear pore complex structure, assembly, and function.

NUP50 NUP54

4.96e-043830212791264
Pubmed

Phase-separated nuclear bodies of nucleoporin fusions promote condensation of MLL1/CRM1 and rearrangement of 3D genome structure.

NUP50 NUP54

5.50e-044030237516964
Pubmed

Targeting USP10 induces degradation of oncogenic ANLN in esophageal squamous cell carcinoma.

KRT72 ALYREF MAGED2 KRT77 DDX1 NUP54

6.21e-04125730636526897
Pubmed

PTENα and PTENβ promote carcinogenesis through WDR5 and H3K4 trimethylation.

ALYREF MAGED2 DDX1

8.59e-0421730331685992
Cytoband10q11.23

TIMM23 WASHC2A

2.15e-043330210q11.23
CytobandEnsembl 112 genes in cytogenetic band chr10q11

TIMM23 WASHC2C WASHC2A

2.53e-04188303chr10q11
Cytoband12q13.13

KRT72 KRT77

8.89e-046730212q13.13
GeneFamilyWASH complex

WASHC2C WASHC2A

2.11e-0562221331
GeneFamilyKeratins, type II

KRT72 KRT77

4.87e-0427222609
GeneFamilyNucleoporins

NUP50 NUP54

6.86e-04322221051
GeneFamilyMAGE family

MAGED2 TRO

1.07e-03402221136
GeneFamilyRNA binding motif containing

RBM5 ALYREF

2.73e-02213222725
CoexpressionFAELT_B_CLL_WITH_VH_REARRANGEMENTS_DN

MAGED2 YY1 DDX1

2.41e-0549303M10389
ToppCellE16.5-samps|World / Age Group, Lineage, Cell class and subclass

RBM5 MEX3A MAGED2 DDX1

2.96e-06149304e94d075f68c1c70c89fab50b1b765b5dda650d09
ToppCellCOVID-19_Mild-Neu_2|COVID-19_Mild / 5 Neutrophil clusters in COVID-19 patients

TIMM23 AMER1 HEATR5B OXR1

5.23e-06172304f5fd08b42c002d4693646b27e7b708eceb49524f
Diseasefacial morphology

IL16 ACTRT2 DNAJC6

2.16e-0555293EFO_0004743
Diseaseperipheral arterial disease, traffic air pollution measurement

CNNM1 IL16 OXR1 STXBP5L

3.78e-05194294EFO_0004265, EFO_0007908
DiseaseHIV Coinfection

ALYREF YY1

4.61e-03103292C4505456
DiseaseHIV Infections

ALYREF YY1

4.61e-03103292C0019693
Diseaseneuroticism measurement

CDH22 OXR1 MAGED2 TRO

1.15e-02909294EFO_0007660

Protein segments in the cluster

PeptideGeneStartEntry
LFSFADFGSALGGGG

ANKRD54

36

Q6NXT1
NGSGFCKAGLSGEFG

ACTRT2

16

Q8TDY3
SFFGGGRSKGSGKGS

AMER1

71

Q5JTC6
GRFSGFGSGAGGKPL

NUP50

71

Q9UKX7
LGGGAALGSEFLGAG

RASA1

61

P20936
FGLFAGLGGAGASTS

MAGED2

581

Q9UNF1
LDLGTDKFGFGFGGT

DDX1

156

Q92499
GLKLGAGKGDAAFGF

MUC19

256

Q7Z5P9
GAGLGFSLAGGADLE

IL16

1121

Q14005
SPDGLGGAFGALDKG

FAM181B

21

A6NEQ2
GAGLGAKGSAYGLSG

RBM5

781

P52756
GLFGGTQNKGFGFGT

NUP54

51

Q7Z3B4
MDSLAFGGGGGEFAL

OXR1

821

Q8N573
TGFLRGGSGFLKSGG

HEATR5B

276

Q9P2D3
GGAGGSGKEFQAALG

EXTL3

641

O43909
SELLSDLFGGGGAAG

DNAJC6

521

O75061
LYDFGELKGGDGGGS

CDH22

691

Q9UJ99
GFFKGLFGGGAQSLD

STXBP5

1046

Q5T5C0
GFLKGLFGGSGQTFD

STXBP5L

1081

Q9Y2K9
EAERGGAGGGGKLFS

CNNM1

171

Q9NRU3
GSDFGGSGSGKLDPG

TIMM13

6

Q9Y5L4
SSGFDGGLGTSAGFG

TRO

1236

Q12816
SAGFGGGLVTSDGFG

TRO

1276

Q12816
FGELGCFGGSAKDRG

MEX3A

16

A1L020
GKKSYLSGGAGAAGG

YY1

181

P25490
FSPFGSGGGLFSGGK

WASHC2C

351

Q9Y4E1
SGGGLFSGGKGLFDD

WASHC2C

356

Q9Y4E1
FSPFGSGGGLFSGGK

WASHC2A

351

Q641Q2
SGGGLFSGGKGLFDD

WASHC2A

356

Q641Q2
GSGNKTTGGLAGFFG

TIMM23

6

O14925
LFDSGFGGGAGVETG

ALYREF

91

Q86V81
GFGGAGFGTSNFGLG

KRT77

111

Q7Z794
LGGFVGTAFGSAGLG

KRT72

71

Q14CN4