Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	carbohydrate transmembrane transporter activity	SLC5A11 TMEM144 SLC2A6 SLC5A4	4.45e-07	42	30	4	GO:0015144
GeneOntologyMolecularFunction	D-glucose transmembrane transporter activity	SLC5A11 SLC2A6 SLC5A4	6.88e-06	25	30	3	GO:0055056
GeneOntologyMolecularFunction	hexose transmembrane transporter activity	SLC5A11 SLC2A6 SLC5A4	6.88e-06	25	30	3	GO:0015149
GeneOntologyMolecularFunction	monosaccharide transmembrane transporter activity	SLC5A11 SLC2A6 SLC5A4	8.74e-06	27	30	3	GO:0015145
GeneOntologyMolecularFunction	sugar transmembrane transporter activity	SLC5A11 SLC2A6 SLC5A4	1.09e-05	29	30	3	GO:0051119
GeneOntologyMolecularFunction	D-glucose:sodium symporter activity	SLC5A11 SLC5A4	4.56e-05	7	30	2	GO:0005412
GeneOntologyMolecularFunction	solute:sodium symporter activity	SLC5A11 SLC6A14 SLC5A4	2.41e-04	81	30	3	GO:0015370
GeneOntologyMolecularFunction	carbohydrate:monoatomic cation symporter activity	SLC5A11 SLC5A4	2.93e-04	17	30	2	GO:0005402
GeneOntologyMolecularFunction	polypeptide N-acetylgalactosaminyltransferase activity	GALNT17 GALNT9	4.08e-04	20	30	2	GO:0004653
GeneOntologyMolecularFunction	solute:monoatomic cation symporter activity	SLC5A11 SLC6A14 SLC5A4	7.45e-04	119	30	3	GO:0015294
GeneOntologyMolecularFunction	acetylgalactosaminyltransferase activity	GALNT17 GALNT9	1.26e-03	35	30	2	GO:0008376
GeneOntologyMolecularFunction	symporter activity	SLC5A11 SLC6A14 SLC5A4	1.45e-03	150	30	3	GO:0015293
GeneOntologyMolecularFunction	transmembrane transporter activity	SLC5A11 TMEM144 SLC2A6 ABCC6 SLC6A14 SLC49A4 SLC5A4	1.51e-03	1180	30	7	GO:0022857
GeneOntologyMolecularFunction	sodium ion transmembrane transporter activity	SLC5A11 SLC6A14 SLC5A4	2.11e-03	171	30	3	GO:0015081
GeneOntologyMolecularFunction	transporter activity	SLC5A11 TMEM144 SLC2A6 ABCC6 SLC6A14 SLC49A4 SLC5A4	2.51e-03	1289	30	7	GO:0005215
GeneOntologyMolecularFunction	hexosyltransferase activity	FUT10 GALNT17 GALNT9	3.83e-03	211	30	3	GO:0016758
GeneOntologyMolecularFunction	active transmembrane transporter activity	SLC5A11 ABCC6 SLC6A14 SLC5A4	5.39e-03	477	30	4	GO:0022804
GeneOntologyMolecularFunction	glycosyltransferase activity	FUT10 GALNT17 GALNT9	9.04e-03	288	30	3	GO:0016757
GeneOntologyMolecularFunction	secondary active transmembrane transporter activity	SLC5A11 SLC6A14 SLC5A4	9.74e-03	296	30	3	GO:0015291
GeneOntologyMolecularFunction	active monoatomic ion transmembrane transporter activity	SLC5A11 SLC6A14 SLC5A4	1.02e-02	301	30	3	GO:0022853
GeneOntologyBiologicalProcess	carbohydrate transmembrane transport	SLC5A11 TMEM144 SLC2A6 SLC5A4	9.86e-05	168	30	4	GO:0034219
GeneOntologyBiologicalProcess	carbohydrate transport	SLC5A11 TMEM144 SLC2A6 SLC5A4	1.46e-04	186	30	4	GO:0008643
GeneOntologyBiologicalProcess	G protein-coupled opsin signaling pathway	GRK4 RHO	1.58e-04	13	30	2	GO:0016056
Domain	NA_SOLUT_SYMP_1	SLC5A11 SLC5A4	1.45e-04	11	31	2	PS00456
Domain	NA_SOLUT_SYMP_2	SLC5A11 SLC5A4	1.74e-04	12	31	2	PS00457
Domain	SSF	SLC5A11 SLC5A4	1.74e-04	12	31	2	PF00474
Domain	Na/solute_symporter	SLC5A11 SLC5A4	1.74e-04	12	31	2	IPR001734
Domain	NA_SOLUT_SYMP_3	SLC5A11 SLC5A4	1.74e-04	12	31	2	PS50283
Domain	Ricin_B_lectin	GALNT17 GALNT9	7.81e-04	25	31	2	PF00652
Domain	RICIN	GALNT17 GALNT9	9.81e-04	28	31	2	SM00458
Domain	HRM	CRHR1 ADGRA3	9.81e-04	28	31	2	PF02793
Domain	RICIN_B_LECTIN	GALNT17 GALNT9	9.81e-04	28	31	2	PS50231
Domain	Glyco_trans_2-like	GALNT17 GALNT9	1.13e-03	30	31	2	IPR001173
Domain	Ricin_B_lectin	GALNT17 GALNT9	1.13e-03	30	31	2	IPR000772
Domain	Glycos_transf_2	GALNT17 GALNT9	1.13e-03	30	31	2	PF00535
Domain	-	TENM1 LRP5L	1.90e-03	39	31	2	2.120.10.30
Domain	G_PROTEIN_RECEP_F2_1	CRHR1 ADGRA3	2.00e-03	40	31	2	PS00649
Domain	G_PROTEIN_RECEP_F2_3	CRHR1 ADGRA3	2.00e-03	40	31	2	PS50227
Domain	GPCR_2_extracellular_dom	CRHR1 ADGRA3	2.00e-03	40	31	2	IPR001879
Domain	6-blade_b-propeller_TolB-like	TENM1 LRP5L	2.64e-03	46	31	2	IPR011042
Domain	G_PROTEIN_RECEP_F2_2	CRHR1 ADGRA3	3.11e-03	50	31	2	PS00650
Domain	7tm_2	CRHR1 ADGRA3	3.11e-03	50	31	2	PF00002
Domain	AGC-kinase_C	CDC42BPG GRK4	3.88e-03	56	31	2	IPR000961
Domain	AGC_KINASE_CTER	CDC42BPG GRK4	3.88e-03	56	31	2	PS51285
Domain	S_TK_X	CDC42BPG GRK4	3.88e-03	56	31	2	SM00133
Domain	GPCR_2-like	CRHR1 ADGRA3	4.44e-03	60	31	2	IPR017981
Domain	GPCR_2_secretin-like	CRHR1 ADGRA3	4.44e-03	60	31	2	IPR000832
Domain	G_PROTEIN_RECEP_F2_4	CRHR1 ADGRA3	4.59e-03	61	31	2	PS50261
Domain	-	GALNT17 GALNT9	7.96e-03	81	31	2	3.90.550.10
Domain	Nucleotide-diphossugar_trans	GALNT17 GALNT9	9.34e-03	88	31	2	IPR029044
Pathway	WP_NRF2_PATHWAY	SLC5A11 SLC2A6 SLC6A14 SLC5A4	7.33e-05	141	23	4	M39454
Pathway	WP_NUCLEAR_RECEPTORS_METAPATHWAY	SLC5A11 IGFBP1 SLC2A6 SLC6A14 SLC5A4	1.28e-04	314	23	5	M39428
Pathway	REACTOME_CELLULAR_HEXOSE_TRANSPORT	SLC2A6 SLC5A4	4.28e-04	19	23	2	MM14718
Pathway	REACTOME_CELLULAR_HEXOSE_TRANSPORT	SLC2A6 SLC5A4	5.25e-04	21	23	2	M27058
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC5A11 SLC2A6 SLC6A14 SLC5A4	5.45e-04	238	23	4	MM15076
Pathway	REACTOME_SLC_MEDIATED_TRANSMEMBRANE_TRANSPORT	SLC5A11 SLC2A6 SLC6A14 SLC5A4	6.46e-04	249	23	4	M5988
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	GALNT17 THSD7A GALNT9	7.12e-04	109	23	3	MM15164
Pathway	REACTOME_O_LINKED_GLYCOSYLATION	GALNT17 THSD7A GALNT9	7.50e-04	111	23	3	M27416
Pathway	KEGG_O_GLYCAN_BIOSYNTHESIS	GALNT17 GALNT9	1.08e-03	30	23	2	M6929
Pathway	REACTOME_THE_PHOTOTRANSDUCTION_CASCADE	GRK4 RHO	1.15e-03	31	23	2	MM14896
Pathway	REACTOME_THE_PHOTOTRANSDUCTION_CASCADE	GRK4 RHO	1.38e-03	34	23	2	M27183
Pathway	WP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS	IGFBP1 CRHR1 GRK4	1.93e-03	154	23	3	MM15974
Pathway	WP_MYOMETRIAL_RELAXATION_AND_CONTRACTION_PATHWAYS	IGFBP1 CRHR1 GRK4	2.00e-03	156	23	3	M39475
Pubmed	Expression, purification, and characterization of the G protein-coupled receptor kinase GRK5.	CHRM2 RHO	2.31e-06	3	31	2	8288567
Pubmed	Association of G-protein-coupled receptor kinase 4 haplotypes, but not HSD3B1 or PTP1B polymorphisms, with essential hypertension.	PTPN1 GRK4	2.31e-06	3	31	2	15097232
Pubmed	GDE2 promotes neurogenesis by glycosylphosphatidylinositol-anchor cleavage of RECK.	GDPD5 EN2	3.44e-05	10	31	2	23329048
Pubmed	Synteny conservation of the Huntington's disease gene and surrounding loci on mouse Chromosome 5.	EN2 GRK4	6.95e-05	14	31	2	7919654
Pubmed	Mapping of five subtype genes for muscarinic acetylcholine receptor to mouse chromosomes.	MS4A1 CHRM2	1.04e-04	17	31	2	10549128
Pubmed	Loss of the disease-associated glycosyltransferase Galnt3 alters Muc10 glycosylation and the composition of the oral microbiome.	GALNT17 GALNT9	2.10e-04	24	31	2	31882545
Pubmed	Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors.	CHRM2 CRHR1 RHO	7.48e-04	200	31	3	18240029
Pubmed	Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.	GALNT17 IGFBP1	8.45e-04	48	31	2	23377640
Pubmed	Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence.	GALNT17 LRP5L THSD7A	8.73e-04	211	31	3	7566098
GeneFamily	Solute carriers	SLC5A11 SLC2A6 SLC6A14 SLC49A4 SLC5A4	7.40e-05	395	21	5	752
GeneFamily	Polypeptide N-acetylgalactosaminyltransferases	GALNT17 GALNT9	2.41e-04	20	21	2	433
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	ADGRA3 MYBPC2	1.48e-02	161	21	2	593
Coexpression	TSUTSUMI_FBXW8_TARGETS	IGFBP1 MYBPC2	4.85e-05	9	31	2	M2187
Coexpression	TSUTSUMI_FBXW8_TARGETS	IGFBP1 MYBPC2	4.85e-05	9	31	2	MM888
Disease	monokine induced by gamma interferon measurement	GALNT17 LRP5L UMODL1	2.24e-05	52	31	3	EFO_0008236
Disease	Mood Disorders	CHRM2 CRHR1 VPS13A	7.25e-04	168	31	3	C0525045
Disease	depressive disorder (biomarker_via_orthology)	CHRM2 CRHR1	1.37e-03	52	31	2	DOID:1596 (biomarker_via_orthology)
Disease	microglial activation measurement	GALNT17 ADGRA3	1.76e-03	59	31	2	EFO_0010940
Disease	household income	THSD7A CRHR1 GRK4	3.93e-03	304	31	3	EFO_0009695
Disease	obesity (is_implicated_in)	CRHR1 SLC6A14	4.13e-03	91	31	2	DOID:9970 (is_implicated_in)
Disease	age-related hearing impairment	FAM187B GALNT17 SLC6A14	4.70e-03	324	31	3	EFO_0005782

Protein segments in the cluster

Peptide	Gene	Start	Entry
CGGWIPWRRCPKMVY	UMODL1	61	Q5DID0
GSRPNAPYCWMAWEP	ADGRA3	901	Q8IWK6
APYCWMAWEPSLGAF	ADGRA3	906	Q8IWK6
IGYWPLGPVVCDLWL	CHRM2	86	P08172
CVTVWYPLWGGIMYI	MS4A1	81	P11836
WVMALACAAPPLAGW	RHO	161	P08100
HELLWPAAPMGWGYA	CDC42BPG	1311	Q6DT37
GPLPNTCGHFWEMVW	PTPN1	86	P18031
WGLRCMYIIPPQDWL	GALNT9	296	Q9HCQ5
MLCWGYWSLGQPGIS	HERC3	1	Q15034
GLCWCVYPWNGKRIP	IGFBP1	226	P08833
PEMGLTYWIDWGENP	LRP5L	86	A4QPB2
SPLWIMPPDEYCLMW	GDPD5	486	Q8WTR4
SPGDLVWAKMEGYPW	MSH6	91	P52701
IMGYAVGWGPITWLL	SLC2A6	406	Q9UGQ3
WGPIGFLPCFAFMWL	SLC49A4	96	Q96SL1
YPIMLWWSPLTGETG	FUT10	81	Q6P4F1
CMYISPPKDWWDAGD	GALNT17	301	Q6IS24
RKWMFICIGWGVPFP	CRHR1	256	P34998
WLDCPLGSMYRPVNW	FAM187B	231	Q17R55
LGAQPMLWPAWVYCT	EN2	206	P19622
SPDWWGLGCLIYEMI	GRK4	366	P32298
PTLYLWKTGPWGRCM	THSD7A	56	Q9UPZ6
GVWVPPMYLWVLGPI	ABCC6	36	O95255
WPGIIFGMPITALWY	SLC5A4	276	Q9NY91
WPGVLFGMSIPSLWY	SLC5A11	271	Q8WWX8
MPLWLVVPGGQVYWL	TENM1	1596	Q9UKZ4
EDGWDLPYIMHLWPP	VPS13A	2096	Q96RL7
CPKFWPFAMLGGCIW	TMEM144	61	Q7Z5S9
VWMPEDTPGGFCLDW	ZNF454	71	Q8N9F8
IPYPDWGVALGWCMI	SLC6A14	556	Q9UN76
GEDWAILVWEPPMYD	MYBPC2	651	Q14324