Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	acetylcholine receptor regulator activity	SPDYE1 SPDYE11 SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16	2.62e-12	27	66	7	GO:0030548
GeneOntologyMolecularFunction	neurotransmitter receptor regulator activity	SPDYE1 SPDYE11 SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16	3.48e-12	28	66	7	GO:0099602
GeneOntologyMolecularFunction	protein kinase binding	SPDYE1 MICAL1 SPDYE11 SPDYE17 SPDYE10 SPDYE15 SPDYE2 SPDYE8 PAM SPDYE21 SPDYE5 SPDYE18 SPDYE12 SPDYE2B SPDYE6 SPDYE14 SPDYE16	2.23e-09	873	66	17	GO:0019901
GeneOntologyMolecularFunction	kinase binding	SPDYE1 MICAL1 SPDYE11 SPDYE17 SPDYE10 SPDYE15 SPDYE2 SPDYE8 PAM SPDYE21 SPDYE5 SPDYE18 SPDYE12 SPDYE2B SPDYE6 SPDYE14 SPDYE16	1.06e-08	969	66	17	GO:0019900
GeneOntologyMolecularFunction	signaling receptor regulator activity	JAG2 SPDYE1 SPDYE11 CSPG5 SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16	1.84e-04	616	66	9	GO:0030545
GeneOntologyBiologicalProcess	positive regulation of cyclin-dependent protein serine/threonine kinase activity	SPDYE1 SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16	4.62e-11	25	55	6	GO:0045737
GeneOntologyBiologicalProcess	positive regulation of cyclin-dependent protein kinase activity	SPDYE1 SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16	9.77e-11	28	55	6	GO:1904031
GeneOntologyBiologicalProcess	regulation of cyclin-dependent protein serine/threonine kinase activity	SPDYE1 SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16	2.09e-07	96	55	6	GO:0000079
GeneOntologyBiologicalProcess	regulation of cyclin-dependent protein kinase activity	SPDYE1 SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16	2.67e-07	100	55	6	GO:1904029
GeneOntologyBiologicalProcess	late endosome to lysosome transport via multivesicular body sorting pathway	VPS4A VPS4B	6.98e-06	2	55	2	GO:0061764
GeneOntologyBiologicalProcess	positive regulation of protein serine/threonine kinase activity	SPDYE1 SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16	1.23e-05	193	55	6	GO:0071902
GeneOntologyBiologicalProcess	late endosomal microautophagy	VPS4A VPS4B	2.09e-05	3	55	2	GO:0061738
GeneOntologyBiologicalProcess	ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway	VPS4A VPS4B	6.95e-05	5	55	2	GO:0090611
GeneOntologyBiologicalProcess	dermatan sulfate biosynthetic process	CHST14 UST	6.95e-05	5	55	2	GO:0030208
GeneOntologyBiologicalProcess	positive regulation of cell cycle	SPDYE1 VPS4B SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16	9.92e-05	407	55	7	GO:0045787
GeneOntologyBiologicalProcess	dermatan sulfate proteoglycan biosynthetic process	CHST14 UST	1.93e-04	8	55	2	GO:0050651
GeneOntologyBiologicalProcess	ESCRT III complex disassembly	VPS4A VPS4B	3.10e-04	10	55	2	GO:1904903
GeneOntologyBiologicalProcess	positive regulation of NK T cell activation	CD1D RASAL3	3.10e-04	10	55	2	GO:0051135
GeneOntologyBiologicalProcess	ESCRT complex disassembly	VPS4A VPS4B	3.10e-04	10	55	2	GO:1904896
GeneOntologyBiologicalProcess	dermatan sulfate metabolic process	CHST14 UST	3.10e-04	10	55	2	GO:0030205
GeneOntologyBiologicalProcess	positive regulation of protein kinase activity	SPDYE1 SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16	3.29e-04	350	55	6	GO:0045860
GeneOntologyBiologicalProcess	regulation of protein serine/threonine kinase activity	SPDYE1 SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16	3.71e-04	358	55	6	GO:0071900
GeneOntologyBiologicalProcess	regulation of exocytosis	MICAL1 STXBP5L VPS4A CSPG5 VPS4B	3.87e-04	233	55	5	GO:0017157
GeneOntologyBiologicalProcess	regulation of NK T cell activation	CD1D RASAL3	4.53e-04	12	55	2	GO:0051133
GeneOntologyBiologicalProcess	dermatan sulfate proteoglycan metabolic process	CHST14 UST	5.34e-04	13	55	2	GO:0050655
GeneOntologyBiologicalProcess	viral budding from plasma membrane	VPS4A VPS4B	6.22e-04	14	55	2	GO:0046761
GeneOntologyBiologicalProcess	mitotic metaphase chromosome alignment	VPS4A VPS4B CHAMP1	6.97e-04	65	55	3	GO:0007080
GeneOntologyBiologicalProcess	positive regulation of kinase activity	SPDYE1 SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16	7.10e-04	405	55	6	GO:0033674
GeneOntologyBiologicalProcess	non-lytic viral release	VPS4A VPS4B	7.17e-04	15	55	2	GO:0046753
GeneOntologyBiologicalProcess	inner ear auditory receptor cell differentiation	JAG2 TPRN STRC	7.62e-04	67	55	3	GO:0042491
GeneOntologyBiologicalProcess	positive regulation of exosomal secretion	VPS4A VPS4B	8.18e-04	16	55	2	GO:1903543
GeneOntologyBiologicalProcess	NK T cell activation	CD1D RASAL3	1.04e-03	18	55	2	GO:0051132
GeneOntologyBiologicalProcess	endosome to lysosome transport via multivesicular body sorting pathway	VPS4A VPS4B	1.16e-03	19	55	2	GO:0032510
GeneOntologyBiologicalProcess	midbody abscission	VPS4A VPS4B	1.16e-03	19	55	2	GO:0061952
GeneOntologyBiologicalProcess	hair cell differentiation	JAG2 TPRN STRC	1.18e-03	78	55	3	GO:0035315
GeneOntologyBiologicalProcess	regulation of exosomal secretion	VPS4A VPS4B	1.29e-03	20	55	2	GO:1903541
Domain	Spy1	SPDYE1 SPDYE2 SPDYE21 SPDYE5 SPDYE2B SPDYE6 SPDYE16	5.50e-16	11	57	7	PF11357
Domain	Speedy	SPDYE1 SPDYE2 SPDYE21 SPDYE5 SPDYE2B SPDYE6 SPDYE16	5.50e-16	11	57	7	IPR020984
Domain	IG_LIKE	MYBPH TARM1 CD1D PXDNL LAG3 SIGLEC10 FCRLB LRRN2	1.15e-04	491	57	8	PS50835
Domain	Ig-like_dom	MYBPH TARM1 CD1D PXDNL LAG3 SIGLEC10 FCRLB LRRN2	1.36e-04	503	57	8	IPR007110
Domain	Vps4_C	VPS4A VPS4B	2.53e-04	8	57	2	PF09336
Domain	Vps4_C	VPS4A VPS4B	2.53e-04	8	57	2	IPR015415
Domain	IG	MYBPH TARM1 PXDNL LAG3 SIGLEC10 FCRLB LRRN2	2.81e-04	421	57	7	SM00409
Domain	Ig_sub	MYBPH TARM1 PXDNL LAG3 SIGLEC10 FCRLB LRRN2	2.81e-04	421	57	7	IPR003599
Domain	MIT	VPS4A VPS4B	4.05e-04	10	57	2	SM00745
Domain	MIT	VPS4A VPS4B	4.05e-04	10	57	2	PF04212
Domain	Sulfotransfer_2	CHST14 UST	5.92e-04	12	57	2	PF03567
Domain	Sulfotransferase	CHST14 UST	5.92e-04	12	57	2	IPR005331
Domain	-	VPS4A VPS4B	6.99e-04	13	57	2	1.20.58.280
Domain	MIT	VPS4A VPS4B	8.13e-04	14	57	2	IPR007330
Domain	-	MYBPH TARM1 CD1D PXDNL LAG3 SIGLEC10 FCRLB LRRN2	8.59e-04	663	57	8	2.60.40.10
Domain	Ig-like_fold	MYBPH TARM1 CD1D PXDNL LAG3 SIGLEC10 FCRLB LRRN2	1.29e-03	706	57	8	IPR013783
Domain	Ig_2	TARM1 SIGLEC10 FCRLB	1.44e-03	73	57	3	PF13895
Domain	Ig_I-set	MYBPH PXDNL SIGLEC10 LRRN2	2.69e-03	190	57	4	IPR013098
Domain	I-set	MYBPH PXDNL SIGLEC10 LRRN2	2.69e-03	190	57	4	PF07679
Domain	ATPase_AAA_CS	VPS4A VPS4B	3.52e-03	29	57	2	IPR003960
Domain	AAA	VPS4A VPS4B	4.82e-03	34	57	2	PS00674
Domain	VWFC_1	JAG2 PXDNL	5.39e-03	36	57	2	PS01208
Domain	IGc2	MYBPH PXDNL SIGLEC10 LRRN2	5.73e-03	235	57	4	SM00408
Domain	Ig_sub2	MYBPH PXDNL SIGLEC10 LRRN2	5.73e-03	235	57	4	IPR003598
Domain	VWC	JAG2 PXDNL	6.00e-03	38	57	2	SM00214
Domain	VWFC_2	JAG2 PXDNL	6.00e-03	38	57	2	PS50184
Domain	-	ELP1 PAM	6.31e-03	39	57	2	2.120.10.30
Domain	VWF_dom	JAG2 PXDNL	7.29e-03	42	57	2	IPR001007
Domain	6-blade_b-propeller_TolB-like	ELP1 PAM	8.69e-03	46	57	2	IPR011042
Domain	AAA	VPS4A VPS4B	1.10e-02	52	57	2	PF00004
Domain	FBOX	FBH1 FBXL19	1.10e-02	52	57	2	SM00256
Domain	ATPase_AAA_core	VPS4A VPS4B	1.18e-02	54	57	2	IPR003959
Pathway	REACTOME_DERMATAN_SULFATE_BIOSYNTHESIS	CHST14 CSPG5 UST	1.81e-06	10	36	3	MM14801
Pathway	REACTOME_DERMATAN_SULFATE_BIOSYNTHESIS	CHST14 CSPG5 UST	2.49e-06	11	36	3	M27105
Pathway	REACTOME_DEFECTIVE_CHST14_CAUSES_EDS_MUSCULOCONTRACTURAL_TYPE	CHST14 CSPG5	1.76e-04	8	36	2	M27260
Pathway	REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM	CHST14 CSPG5 UST	2.44e-04	48	36	3	MM14696
Pathway	REACTOME_CHONDROITIN_SULFATE_DERMATAN_SULFATE_METABOLISM	CHST14 CSPG5 UST	2.76e-04	50	36	3	M678
Pathway	REACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES	COL4A3 COL6A6 ADAMTS14	4.97e-04	61	36	3	MM14637
Pathway	REACTOME_COLLAGEN_BIOSYNTHESIS_AND_MODIFYING_ENZYMES	COL4A3 COL6A6 ADAMTS14	6.55e-04	67	36	3	M26999
Pathway	REACTOME_COLLAGEN_FORMATION	COL4A3 COL6A6 ADAMTS14	9.46e-04	76	36	3	MM14573
Pathway	REACTOME_NCAM1_INTERACTIONS	COL4A3 COL6A6	1.17e-03	20	36	2	MM15061
Pathway	KEGG_GLYCOSAMINOGLYCAN_BIOSYNTHESIS_CHONDROITIN_SULFATE	CHST14 UST	1.42e-03	22	36	2	M19166
Pathway	REACTOME_COLLAGEN_FORMATION	COL4A3 COL6A6 ADAMTS14	1.54e-03	90	36	3	M631
Pubmed	Identification and comparative analysis of multiple mammalian Speedy/Ringo proteins.	SPDYE1 SPDYE17 SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16	1.67e-16	13	70	7	15611625
Pubmed	Characterization of a new family of cyclin-dependent kinase activators.	SPDYE1 SPDYE17 SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16	1.88e-15	17	70	7	15574121
Pubmed	Murine fertility and spermatogenesis are independent of the testis-specific Spdye4a gene.	SPDYE1 SPDYE2 SPDYE5 SPDYE2B SPDYE6 SPDYE16	4.46e-15	9	70	6	36272447
Pubmed	Evolution of the Cdk-activator Speedy/RINGO in vertebrates.	SPDYE17 SPDYE2 SPDYE6	7.81e-09	3	70	3	22763696
Pubmed	Synthetic lethality between VPS4A and VPS4B triggers an inflammatory response in colorectal cancer.	VPS4A VPS4B	3.99e-06	2	70	2	31930723
Pubmed	Analysis of individual HIV-1 budding event using fast AFM reveals a multiplexed role for VPS4.	VPS4A VPS4B	3.99e-06	2	70	2	36042696
Pubmed	Comparative sequence and expression analyses of four mammalian VPS4 genes.	VPS4A VPS4B	3.99e-06	2	70	2	12594041
Pubmed	Three-dimensional structure of AAA ATPase Vps4: advancing structural insights into the mechanisms of endosomal sorting and enveloped virus budding.	VPS4A VPS4B	3.99e-06	2	70	2	19278657
Pubmed	CDK activation by non-cyclin proteins.	SPDYE17 SPDYE6	3.99e-06	2	70	2	16488127
Pubmed	Synthetic Lethal Interaction between the ESCRT Paralog Enzymes VPS4A and VPS4B in Cancers Harboring Loss of Chromosome 18q or 16q.	VPS4A VPS4B	3.99e-06	2	70	2	33326793
Pubmed	Mammalian cells express two VPS4 proteins both of which are involved in intracellular protein trafficking.	VPS4A VPS4B	3.99e-06	2	70	2	11563910
Pubmed	Influenza virus budding does not require a functional AAA+ ATPase, VPS4.	VPS4A VPS4B	3.99e-06	2	70	2	20621136
Pubmed	Phosphatidylethanolamine, a limiting factor of autophagy in yeast strains bearing a defect in the carboxypeptidase Y pathway of vacuolar targeting.	VPS4A VPS4B	3.99e-06	2	70	2	17428789
Pubmed	The VPS4 gene is involved in protein transport out of a yeast pre-vacuolar endosome-like compartment.	VPS4A VPS4B	3.99e-06	2	70	2	9211789
Pubmed	Identification of pauses during formation of HIV-1 virus like particles.	VPS4A VPS4B	3.99e-06	2	70	2	24268138
Pubmed	Established and novel Cdk/cyclin complexes regulating the cell cycle and development.	SPDYE17 SPDYE6	3.99e-06	2	70	2	21630153
Pubmed	Cloning, characterisation, and functional expression of the Mus musculus SKD1 gene in yeast demonstrates that the mouse SKD1 and the yeast VPS4 genes are orthologues and involved in intracellular protein trafficking.	VPS4A VPS4B	3.99e-06	2	70	2	10393249
Pubmed	Budding of filamentous and non-filamentous influenza A virus occurs via a VPS4 and VPS28-independent pathway.	VPS4A VPS4B	1.20e-05	3	70	2	19524996
Pubmed	Hepatitis B virus maturation is sensitive to functional inhibition of ESCRT-III, Vps4, and gamma 2-adaptin.	VPS4A VPS4B	1.20e-05	3	70	2	17553870
Pubmed	Microautophagy of cytosolic proteins by late endosomes.	VPS4A VPS4B	1.20e-05	3	70	2	21238931
Pubmed	Regulation of HTLV-1 Gag budding by Vps4A, Vps4B, and AIP1/Alix.	VPS4A VPS4B	1.20e-05	3	70	2	17601348
Pubmed	Identification of an inhibitory budding signal that blocks the release of HIV particles and exosome/microvesicle proteins.	VPS4A VPS4B	1.20e-05	3	70	2	21248205
Pubmed	Oversulfated chondroitin sulfate plays critical roles in the neuronal migration in the cerebral cortex.	CHST14 UST	1.20e-05	3	70	2	18819920
Pubmed	Structural and mechanistic studies of VPS4 proteins.	VPS4A VPS4B	1.20e-05	3	70	2	16193069
Pubmed	Structure and ESCRT-III protein interactions of the MIT domain of human VPS4A.	VPS4A VPS4B	1.20e-05	3	70	2	16174732
Pubmed	Cholesterol depletion facilitates ubiquitylation of NPC1 and its association with SKD1/Vps4.	VPS4A VPS4B	1.20e-05	3	70	2	16757520
Pubmed	Integrative analysis of large-scale loss-of-function screens identifies robust cancer-associated genetic interactions.	VPS4A VPS4B	2.39e-05	4	70	2	32463358
Pubmed	Human immunodeficiency virus type 1 Nef protein targets CD4 to the multivesicular body pathway.	VPS4A VPS4B	2.39e-05	4	70	2	19403684
Pubmed	Mechanism of Ca²⁺-triggered ESCRT assembly and regulation of cell membrane repair.	VPS4A VPS4B	2.39e-05	4	70	2	25534348
Pubmed	ESCRT-dependent control of craniofacial morphogenesis with concomitant perturbation of NOTCH signaling.	JAG2 VPS4A VPS4B	3.37e-05	31	70	3	37573008
Pubmed	The ESCRT-0 component HRS is required for HIV-1 Vpu-mediated BST-2/tetherin down-regulation.	VPS4A VPS4B	3.98e-05	5	70	2	21304933
Pubmed	Involvement of vacuolar protein sorting pathway in Ebola virus release independent of TSG101 interaction.	VPS4A VPS4B	3.98e-05	5	70	2	17940959
Pubmed	The interferon-induced gene ISG15 blocks retrovirus release from cells late in the budding process.	VPS4A VPS4B	5.96e-05	6	70	2	20164219
Pubmed	The Mammalian Orthologs of Drosophila Lgd, CC2D1A and CC2D1B, Function in the Endocytic Pathway, but Their Individual Loss of Function Does Not Affect Notch Signalling.	VPS4A VPS4B	5.96e-05	6	70	2	26720614
Pubmed	ESCRT-III recognition by VPS4 ATPases.	VPS4A VPS4B	5.96e-05	6	70	2	17928862
Pubmed	Interactions of the human LIP5 regulatory protein with endosomal sorting complexes required for transport.	VPS4A VPS4B	8.33e-05	7	70	2	23105106
Pubmed	Biochemical analyses of human IST1 and its function in cytokinesis.	VPS4A VPS4B	8.33e-05	7	70	2	19129479
Pubmed	Novel interactions of ESCRT-III with LIP5 and VPS4 and their implications for ESCRT-III disassembly.	VPS4A VPS4B	8.33e-05	7	70	2	18385515
Pubmed	CHMP1 functions as a member of a newly defined family of vesicle trafficking proteins.	VPS4A VPS4B	1.11e-04	8	70	2	11559748
Pubmed	Expression of multiple chondroitin/dermatan sulfotransferases in the neurogenic regions of the embryonic and adult central nervous system implies that complex chondroitin sulfates have a role in neural stem cell maintenance.	CHST14 UST	1.11e-04	8	70	2	18079434
Pubmed	ALIX binds a YPX(3)L motif of the GPCR PAR1 and mediates ubiquitin-independent ESCRT-III/MVB sorting.	VPS4A VPS4B	1.11e-04	8	70	2	22547407
Pubmed	ESCRT requirements for EIAV budding.	VPS4A VPS4B	1.11e-04	8	70	2	24107264
Pubmed	New insights into HIV assembly and trafficking.	VPS4A VPS4B	2.17e-04	11	70	2	21841072
Pubmed	ESCRT machinery is required for plasma membrane repair.	VPS4A VPS4B	3.07e-04	13	70	2	24482116
Pubmed	ESCRT-III controls nuclear envelope reformation.	VPS4A VPS4B	3.58e-04	14	70	2	26040713
Pubmed	Syndecan-syntenin-ALIX regulates the biogenesis of exosomes.	VPS4A VPS4B	3.58e-04	14	70	2	22660413
Pubmed	Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing.	VPS4A VPS4B	4.12e-04	15	70	2	26040712
Pubmed	A single-cell atlas of mouse lung development.	COL4A3 CA4	4.12e-04	15	70	2	34927678
Pubmed	Recycling of ESCRTs by the AAA-ATPase Vps4 is regulated by a conserved VSL region in Vta1.	VPS4A VPS4B	4.12e-04	15	70	2	16505166
Pubmed	AIP1/ALIX is a binding partner for HIV-1 p6 and EIAV p9 functioning in virus budding.	VPS4A VPS4B	4.12e-04	15	70	2	14505569
Pubmed	Human ESCRT-III and VPS4 proteins are required for centrosome and spindle maintenance.	VPS4A VPS4B	4.12e-04	15	70	2	20616062
Pubmed	Membrane scission by the ESCRT-III complex.	VPS4A VPS4B	4.12e-04	15	70	2	19234443
Pubmed	The protein network of HIV budding.	VPS4A VPS4B	5.98e-04	18	70	2	14505570
Pubmed	MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage.	ELP1 KANK2	1.16e-03	25	70	2	32528060
Pubmed	E-cadherin expression on multiple myeloma cells activates tumor-promoting properties in plasmacytoid DCs.	MICAL1 TPRN	1.46e-03	28	70	2	30277474
Pubmed	Membrane budding and scission by the ESCRT machinery: it's all in the neck.	VPS4A VPS4B	1.57e-03	29	70	2	20588296
Pubmed	The DNA sequence of human chromosome 7.	SPDYE21 SPDYE5 SPDYE2B SPDYE6 SPDYE16	1.97e-03	441	70	5	12853948
Cytoband	Ensembl 112 genes in cytogenetic band chr7q11	SPDYE11 SPDYE17 SPDYE10 SPDYE13 SPDYE15 SPDYE8 SPDYE21 SPDYE9 SPDYE5 SPDYE18 SPDYE12 SPDYE14 SPDYE16	4.11e-16	271	72	13	chr7q11
Cytoband	7q11.23	SPDYE10 SPDYE8 SPDYE9 SPDYE5 SPDYE18 SPDYE14	1.06e-08	97	72	6	7q11.23
Cytoband	7q22.1	SPDYE2 SPDYE2B SPDYE6	7.65e-04	113	72	3	7q22.1
Cytoband	Ensembl 112 genes in cytogenetic band chr3p21	RNF123 CCDC71 CELSR3 CSPG5	1.57e-03	316	72	4	chr3p21
Cytoband	1q23.3	PRRC2C FCRLB	2.72e-03	49	72	2	1q23.3
GeneFamily	Speedy/RINGO cell cycle regulator family	SPDYE1 SPDYE2 SPDYE8 SPDYE9 SPDYE5 SPDYE2B SPDYE6	3.36e-16	12	46	7	756
GeneFamily	AAA ATPases\|ESCRT-IV	VPS4A VPS4B	1.90e-05	3	46	2	1120
GeneFamily	Sulfotransferases, membrane bound	CHST14 UST	3.99e-03	37	46	2	763
GeneFamily	Collagens	COL4A3 COL6A6	6.10e-03	46	46	2	490
GeneFamily	Blood group antigens\|CD molecules\|I-set domain containing\|Immunoglobulin like domain containing	MYBPH PXDNL LRRN2	7.95e-03	161	46	3	593
GeneFamily	AAA ATPases	VPS4A VPS4B	8.04e-03	53	46	2	413
Disease	tumor necrosis factor ligand superfamily member 6, soluble form measurement	RNF123 CELSR3	7.12e-05	7	55	2	EFO_0020797
Disease	attention deficit hyperactivity disorder (implicated_via_orthology)	VPS4A VPS4B	1.25e-03	28	55	2	DOID:1094 (implicated_via_orthology)
Disease	hepatocyte growth factor-like protein measurement	CCDC71 CELSR3	2.30e-03	38	55	2	EFO_0008154
Disease	thioredoxin domain-containing protein 12 measurement	RNF123 CELSR3	2.42e-03	39	55	2	EFO_0008298
Disease	Hereditary hearing loss and deafness	COL4A3 TPRN STRC	2.58e-03	146	55	3	cv:C0236038
Disease	suicide behaviour	ADAMTS14 IRAG1	3.07e-03	44	55	2	EFO_0007623
Disease	Nonsyndromic Hearing Loss and Deafness, Autosomal Recessive	TPRN STRC	4.10e-03	51	55	2	cv:CN043650

Protein segments in the cluster

Peptide	Gene	Start	Entry
RGAASSPRPWSKPGP	C1orf167	1426	Q5SNV9
KPGLGPGTGQPTSRW	CSPG5	306	O95196
SRPGLRGAPGWPGLK	COL4A3	386	Q01955
WARNAPPTRLPKGVG	PAM	136	P19021
ARSPLHPGGTLWPGR	ADAMTS14	86	Q8WXS8
RAVRPGSGGPLLSWP	FBXL19	371	Q6PCT2
SAGPWPRPKGSLSMG	RASAL3	831	Q86YV0
KGSGRPLPGRKRQPW	NOP9	26	Q86U38
PRGVGEPRKGVVPSW	MAGIX	216	Q9H6Y5
GRSPGRPAHWASGPK	JAG2	1206	Q9Y219
RKGVGGRRPLPPAWA	LRRN2	656	O75325
LLKTGWEGSPLPRSP	IRAG1	326	Q9Y6F6
LRARWGSLPPPGGLG	NAT14	81	Q8WUY8
FTGLQPPPRKGSGWR	MICAL1	181	Q8TDZ2
PVAGLGPALAWKPSG	ELP1	236	O95163
RSFLTAKWTPPGGGP	LAG3	291	P18627
RVTGWGSLRPGVPLP	PRSS33	161	Q8NF86
ISGPPKKRHRGWYPG	GREB1L	321	Q9C091
PRGLLKTGFPWPPSG	PXDNL	916	A1KZ92
PSRGRGAPSLRWPAK	LINC00472	31	Q9H8W2
GAPSLRWPAKEVGPR	LINC00472	36	Q9H8W2
PRKGPNPGPWTRAAA	LINC00482	196	Q8N8I6
RLGPRSPKAWLGPGT	CCDC71	406	Q8IV32
PGSPGSAPPSRKRSW	FBH1	111	Q8NFZ0
VIKSGAPGRPLPWAL	CA4	281	P22748
KAWLSRGPSPGPGRL	CD1D	206	P15813
PLRPGGWAPDGLKHL	EPOP	76	A6NHQ4
GLKHLWAPTGRPGVP	EPOP	86	A6NHQ4
RRPAPAVSPGSWKPG	CHAMP1	301	Q96JM3
RRPRLSSLPRGPGSW	KANK2	66	Q63ZY3
VRKRSPWLQLPGPGS	FCRLB	276	Q6BAA4
PPWRGLGGRSTPILL	CELSR3	6	Q9NYQ7
RGWPGPPGTPGSRRK	COL6A6	1536	A6NMZ7
GPGLTDWLFPRRCPK	EPPIN	21	O95925
LGGLPPLTGFLPKWA	MT-ND2	251	P03891
KGLRGRGPPPSWASE	PRRC2C	276	Q9Y520
GVDPSPPRRSLGWKR	SPDYE10	46	P0DUX0
GVDPSPPRRSLGWKR	SPDYE11	46	P0DTA3
GVDPSPPRRSLGWKR	SPDYE8	46	P0DUD1
KPGPPSSIRLLDVWG	MYBPH	266	Q13203
RSLGPPGWSKSRAPA	RNF217	71	Q8TC41
PAPGLSPRQGWEGAK	SEBOX	131	Q9HB31
GVDPSPPCRSLGWKR	SPDYE2B	56	A6NHP3
GKAKQLWGPPRGFRP	STRC	1511	Q7RTU9
WGPGRPPFRKAQSAA	STXBP5L	781	Q9Y2K9
PGREGTAWRGKAPKP	CHST14	76	Q8NCH0
RRTKGPGLRKLWGPG	LINC00477	146	Q96M19
PGLGSWKRRVPLLPF	UST	26	Q9Y2C2
PWRGILLFGPPGTGK	VPS4B	166	O75351
KGTCPPPASGGWLRL	WDR90	1096	Q96KV7
VGGPLPLPRPGWLSS	RNF123	661	Q5XPI4
PLPRPGWLSSPTLGR	RNF123	666	Q5XPI4
GVDPSPPRRSLGWKR	SPDYE12	46	P0DUX1
GVDPSPPRRSLGWKR	SPDYE13	46	A0A494C0Z2
GVDPSPPRRSLGWKR	SPDYE14	46	P0DUD3
GVDPSPPRRSLGWKR	SPDYE15	46	P0DUD4
GVDPSPPCRSLGWKR	SPDYE16	16	A6NNV3
GVDPSPPRRSLGWKR	SPDYE17	46	P0DUD2
GVDPSPPCRSLGWKR	SPDYE18	56	P0DV79
GVDPSPPCRSLGWKR	SPDYE21	56	A0A494C086
GVDPSPPCRSLGWKR	SPDYE2	56	Q495Y8
GVDPSPPCRSLGWKR	SPDYE5	56	A6NIY4
GVDPSPPCRSLGWKR	SPDYE6	56	P0CI01
PLPTRLRPLGGPGLW	SPOCD1	976	Q6ZMY3
LRPLGGPGLWALPVS	SPOCD1	981	Q6ZMY3
GVDPSPPCRSLGWKR	SPDYE1	16	Q8NFV5
PRSAPPGKWALAGPG	HIVEP3	2081	Q5T1R4
WGILGLGPRSPPRGS	ARHGAP9	11	Q9BRR9
RLRGGTWTPRLPPTL	PYCARD-AS1	101	I3L0S3
SPTLSRRPLRGGWAP	ZSWIM8	1156	A7E2V4
VRRGPKSLCLPAWGP	UTS2R	191	Q9UKP6
RPGSGPRAAVPAWKR	TPRN	6	Q4KMQ1
GVDPSPPCRSLGWKR	nan	16	A6NJR5
GVDPSPPRRSLGWKR	SPDYE9	46	A0A494C191
WGPRPLGLELPGVKA	SIGLEC10	301	Q96LC7
WGQQPGGPGPAKRSR	PRR23C	16	Q6ZRP0
GLSPPGWTGRSLLRP	nan	86	Q8NAQ8
RGDGSLPKPSLSAWP	TARM1	21	B6A8C7
KRTPWRGILLFGPPG	VPS4A	156	Q9UN37