Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNAH17 DNAH6 DNAH9 DNAH7	3.02e-07	18	65	4	GO:0008569
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DNAH17 DNAH6 DNAH9 DNAH7	1.97e-06	28	65	4	GO:0051959
GeneOntologyMolecularFunction	dynein intermediate chain binding	DNAH17 DNAH6 DNAH9 DNAH7	6.23e-06	37	65	4	GO:0045505
GeneOntologyMolecularFunction	microtubule motor activity	DNAH17 DNAH6 DNAH9 DNAH7	7.98e-05	70	65	4	GO:0003777
GeneOntologyMolecularFunction	coreceptor activity	RAMP3 CD80 RECK NRP1	8.91e-05	72	65	4	GO:0015026
GeneOntologyMolecularFunction	guanylate cyclase activity	NPR2 GUCY1B1	4.62e-04	10	65	2	GO:0004383
GeneOntologyMolecularFunction	cytoskeletal motor activity	DNAH17 DNAH6 DNAH9 DNAH7	5.94e-04	118	65	4	GO:0003774
GeneOntologyBiologicalProcess	response to redox state	RNF7 SELENOS RYR2	1.11e-05	14	66	3	GO:0051775
GeneOntologyBiologicalProcess	blood vessel endothelial cell fate specification	RBPJ NRP1	6.03e-05	4	66	2	GO:0097101
GeneOntologyBiologicalProcess	blood vessel endothelial cell fate commitment	RBPJ NRP1	6.03e-05	4	66	2	GO:0060846
GeneOntologyCellularComponent	axonemal dynein complex	DNAH17 DNAH6 DNAH9 DNAH7	1.03e-06	25	65	4	GO:0005858
GeneOntologyCellularComponent	dynein complex	DNAH17 DNAH6 DNAH9 DNAH7	2.40e-05	54	65	4	GO:0030286
GeneOntologyCellularComponent	inner dynein arm	DNAH6 DNAH7	4.22e-04	10	65	2	GO:0036156
GeneOntologyCellularComponent	outer dynein arm	DNAH17 DNAH9	6.16e-04	12	65	2	GO:0036157
GeneOntologyCellularComponent	motile cilium	DNAH17 OXCT2 PFKM DNAH6 DNAH9 DNAH7	8.17e-04	355	65	6	GO:0031514
GeneOntologyCellularComponent	9+2 motile cilium	DNAH17 PFKM DNAH6 DNAH9 DNAH7	8.69e-04	238	65	5	GO:0097729
Domain	Dynein_heavy_chain_D4_dom	DNAH6 DNAH9 DNAH7	1.42e-05	14	65	3	IPR024317
Domain	Dynein_HC_stalk	DNAH6 DNAH9 DNAH7	1.42e-05	14	65	3	IPR024743
Domain	Dynein_heavy_dom-2	DNAH6 DNAH9 DNAH7	1.42e-05	14	65	3	IPR013602
Domain	DHC_N2	DNAH6 DNAH9 DNAH7	1.42e-05	14	65	3	PF08393
Domain	MT	DNAH6 DNAH9 DNAH7	1.42e-05	14	65	3	PF12777
Domain	AAA_8	DNAH6 DNAH9 DNAH7	1.42e-05	14	65	3	PF12780
Domain	DHC_fam	DNAH6 DNAH9 DNAH7	1.78e-05	15	65	3	IPR026983
Domain	Dynein_heavy_dom	DNAH6 DNAH9 DNAH7	1.78e-05	15	65	3	IPR004273
Domain	Dynein_heavy	DNAH6 DNAH9 DNAH7	1.78e-05	15	65	3	PF03028
Domain	Ago_hook	TNRC6B TNRC6C	3.57e-05	3	65	2	PF10427
Domain	TNRC6_PABC-bd	TNRC6B TNRC6C	3.57e-05	3	65	2	IPR032226
Domain	Argonaute_hook_dom	TNRC6B TNRC6C	3.57e-05	3	65	2	IPR019486
Domain	TNRC6-PABC_bdg	TNRC6B TNRC6C	3.57e-05	3	65	2	PF16608
Domain	Surp	SUGP2 U2SURP	1.77e-04	6	65	2	PF01805
Domain	SWAP	SUGP2 U2SURP	1.77e-04	6	65	2	SM00648
Domain	SURP	SUGP2 U2SURP	1.77e-04	6	65	2	PS50128
Domain	Surp	SUGP2 U2SURP	1.77e-04	6	65	2	IPR000061
Domain	ATPase_dyneun-rel_AAA	DNAH6 DNAH9	1.06e-03	14	65	2	IPR011704
Domain	AAA_5	DNAH6 DNAH9	1.06e-03	14	65	2	PF07728
Domain	A/G_cyclase_CS	NPR2 GUCY1B1	1.57e-03	17	65	2	IPR018297
Domain	Nucleotide_cyclase	NPR2 GUCY1B1	1.76e-03	18	65	2	IPR029787
Domain	-	NPR2 GUCY1B1	1.76e-03	18	65	2	3.30.70.1230
Domain	GUANYLATE_CYCLASE_1	NPR2 GUCY1B1	1.96e-03	19	65	2	PS00452
Domain	Guanylate_cyc	NPR2 GUCY1B1	1.96e-03	19	65	2	PF00211
Domain	GUANYLATE_CYCLASE_2	NPR2 GUCY1B1	1.96e-03	19	65	2	PS50125
Domain	A/G_cyclase	NPR2 GUCY1B1	1.96e-03	19	65	2	IPR001054
Domain	CYCc	NPR2 GUCY1B1	1.96e-03	19	65	2	SM00044
Domain	G_patch	SUGP2 PINX1	2.88e-03	23	65	2	SM00443
Domain	G_patch_dom	SUGP2 PINX1	2.88e-03	23	65	2	IPR000467
Domain	G_PATCH	SUGP2 PINX1	2.88e-03	23	65	2	PS50174
Domain	G-patch	SUGP2 PINX1	2.88e-03	23	65	2	PF01585
Domain	VWF_A	RO60 VWA2 ITIH2	4.97e-03	99	65	3	IPR002035
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SOD1_TO_RETROGRADE_AXONAL_TRANSPORT	DNAH17 DNAH6 DNAH9 DNAH7	3.93e-06	27	57	4	M47755
Pathway	KEGG_MEDICUS_REFERENCE_RETROGRADE_AXONAL_TRANSPORT	DNAH17 DNAH6 DNAH9 DNAH7	2.64e-05	43	57	4	M47669
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_RETROGRADE_AXONAL_TRANSPORT	DNAH17 DNAH6 DNAH9 DNAH7	3.16e-05	45	57	4	M47670
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	EPRS1 GBF1 PI4KA U2SURP RBPJ CCAR1 RO60 NUP214 PFKM ECPAS NSUN2 PHGDH MYBPC1 RAD21	3.70e-07	1425	66	14	30948266
Pubmed	A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.	GBF1 ZNF485 CCAR1 XPNPEP1 VWA2 ITIH2 CHUK NRP1	1.21e-06	415	66	8	16385451
Pubmed	Prominin 1 and Notch regulate ciliary length and dynamics in multiciliated cells of the airway epithelium.	RBPJ DNAH6 DNAH9	1.84e-06	13	66	3	35942101
Pubmed	The NEDD8 E3 ligase DCNL5 is phosphorylated by IKK alpha during Toll-like receptor activation.	RNF7 DCUN1D5 CHUK	1.84e-06	13	66	3	29958295
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH17 DNAH6 DNAH7	2.34e-06	14	66	3	9373155
Pubmed	High-sensitivity profiling of SARS-CoV-2 noncoding region-host protein interactome reveals the potential regulatory role of negative-sense viral RNA.	EPRS1 POLR3D SUGP2 U2SURP PINX1 RO60 NSUN2 PHGDH	2.98e-06	469	66	8	37314180
Pubmed	O-glucosylation and O-fucosylation occur together in close proximity on the first epidermal growth factor repeat of AMACO (VWA2 protein).	EGF VWA2	3.55e-06	2	66	2	18434322
Pubmed	The phosphatidylinositol 4-kinase PI4KIIIalpha is required for the recruitment of GBF1 to Golgi membranes.	GBF1 PI4KA	3.55e-06	2	66	2	20530568
Pubmed	SHLD2/FAM35A co-operates with REV7 to coordinate DNA double-strand break repair pathway choice.	PI4KA NSUN2 CPVL PHGDH RAD21	1.01e-05	150	66	5	30154076
Pubmed	Epidermal growth factor receptor signaling-dependent calcium elevation in cumulus cells is required for NPR2 inhibition and meiotic resumption in mouse oocytes.	NPR2 EGF	1.06e-05	3	66	2	23787120
Pubmed	Impact of scaffolding protein TNRC6 paralogs on gene expression and splicing.	TNRC6B TNRC6C	1.06e-05	3	66	2	34108231
Pubmed	Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development.	TNRC6B TNRC6C	1.06e-05	3	66	2	16880270
Pubmed	Expression of TNRC6 (GW182) Proteins Is Not Necessary for Gene Silencing by Fully Complementary RNA Duplexes.	TNRC6B TNRC6C	1.06e-05	3	66	2	31670606
Pubmed	Secretoneurin induces airway mucus hypersecretion by enhancing the binding of EGF to NRP1.	EGF NRP1	2.12e-05	4	66	2	24556756
Pubmed	Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing.	TNRC6B TNRC6C	2.12e-05	4	66	2	21063388
Pubmed	The deubiquitinase JOSD2 is a positive regulator of glucose metabolism.	PFKM PHGDH	2.12e-05	4	66	2	33082514
Pubmed	Identification, tissue specific expression, and chromosomal localisation of several human dynein heavy chain genes.	DNAH6 DNAH9	2.12e-05	4	66	2	11175280
Pubmed	Hepatitis B Virus HBx Protein Mediates the Degradation of Host Restriction Factors through the Cullin 4 DDB1 E3 Ubiquitin Ligase Complex.	GBF1 PI4KA XPNPEP1 ECPAS ITIH2 CHUK	2.48e-05	304	66	6	32235678
Pubmed	High-resolution photocatalytic mapping of SARS-CoV-2 spike interactions on the cell surface.	MOXD1 USP43 TNRC6B TNRC6C NRP1 RAD21	2.62e-05	307	66	6	37499664
Pubmed	USP53 plays an antitumor role in hepatocellular carcinoma through deubiquitination of cytochrome c.	EPRS1 SUGP2 U2SURP NUP214	2.67e-05	90	66	4	35654790
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	EPRS1 GBF1 SUGP2 CCAR1 NUP214 ECPAS PHGDH RAD21	2.76e-05	638	66	8	33239621
Pubmed	Primary Ciliary Dyskinesia Associated Disease-Causing Variants in CCDC39 and CCDC40 Cause Axonemal Absence of Inner Dynein Arm Heavy Chains DNAH1, DNAH6, and DNAH7.	DNAH6 DNAH7	3.53e-05	5	66	2	39056782
Pubmed	Ago-TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps.	TNRC6B TNRC6C	3.53e-05	5	66	2	19838187
Pubmed	Identification of SUMO Binding Proteins Enriched after Covalent Photo-Cross-Linking.	EPRS1 NUP214 XPNPEP1 PFKM NSUN2 RAD21	4.06e-05	332	66	6	32786267
Pubmed	CHK2-BRCA1 tumor-suppressor axis restrains oncogenic Aurora-A kinase to ensure proper mitotic microtubule assembly.	EPRS1 TNRC6B NUP214 TNRC6C PFKM ECPAS PHGDH	4.22e-05	494	66	7	26831064
Pubmed	ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection.	RNF7 TIA1 DCUN1D5 TNRC6B TNRC6C NSUN2	4.34e-05	336	66	6	31253590
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	EPRS1 SUGP2 PI4KA U2SURP CCAR1 AKAP10 NUP214 SNX33 PFKM NSUN2 PHGDH	4.46e-05	1353	66	11	29467282
Pubmed	Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.	SUGP2 U2SURP ECPAS DNAH9	4.72e-05	104	66	4	9205841
Pubmed	HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation.	EPRS1 GBF1 SUGP2 CCAR1 TNRC6B PINX1 SNX33 NSUN2 ITIH2 PHGDH NRP1	5.03e-05	1371	66	11	36244648
Pubmed	Notch-1 activates estrogen receptor-alpha-dependent transcription via IKKalpha in breast cancer cells.	RBPJ CHUK	5.29e-05	6	66	2	19838210
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	SUGP2 U2SURP CCAR1 ECPAS NSUN2	6.32e-05	220	66	5	35785414
Pubmed	N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective.	EPRS1 SUGP2 U2SURP TNRC6B NUP214 PFKM NSUN2 PHGDH RAD21	6.57e-05	934	66	9	33916271
Pubmed	Prohibitin 1 regulates tumor cell apoptosis via the interaction with X-linked inhibitor of apoptosis protein.	EPRS1 TIA1 TNRC6B RO60 TNRC6C PFKM NSUN2 PHGDH	6.79e-05	725	66	8	27025967
Pubmed	Human transcription factor protein interaction networks.	ACTR8 SUGP2 RBPJ ZNF485 CCAR1 TNRC6B NUP214 TNRC6C NSUN2 CPVL RAD21	7.29e-05	1429	66	11	35140242
Pubmed	Functional dissection of the human TNRC6 (GW182-related) family of proteins.	TNRC6B TNRC6C	7.40e-05	7	66	2	19470757
Pubmed	The C-terminal domains of human TNRC6A, TNRC6B, and TNRC6C silence bound transcripts independently of Argonaute proteins.	TNRC6B TNRC6C	7.40e-05	7	66	2	19383768
Pubmed	Mutations in DNAH17, Encoding a Sperm-Specific Axonemal Outer Dynein Arm Heavy Chain, Cause Isolated Male Infertility Due to Asthenozoospermia.	DNAH17 DNAH9	7.40e-05	7	66	2	31178125
Pubmed	An improved smaller biotin ligase for BioID proximity labeling.	TNRC6B NUP214 DNAH9 RYR2	9.06e-05	123	66	4	26912792
Pubmed	Fibroblast growth factor receptor signaling promotes radial glial identity and interacts with Notch1 signaling in telencephalic progenitors.	EGF RBPJ	9.86e-05	8	66	2	15509736
Pubmed	Cetuximab as second-line therapy in patients with metastatic esophageal adenocarcinoma: a phase II Southwest Oncology Group Study (S0415).	EGF NRP1	9.86e-05	8	66	2	20631636
Pubmed	Interactome analyses revealed that the U1 snRNP machinery overlaps extensively with the RNAP II machinery and contains multiple ALS/SMA-causative proteins.	TIA1 SUGP2 U2SURP CCAR1 RO60	1.03e-04	244	66	5	29884807
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	EPRS1 GBF1 SUGP2 CCAR1 NUP214 SNX33 ECPAS NSUN2	1.07e-04	774	66	8	15302935
Pubmed	Multi-omics profiling identifies a deregulated FUS-MAP1B axis in ALS/FTD-associated UBQLN2 mutants.	EPRS1 PFKM CPT1A NSUN2 PHGDH	1.29e-04	256	66	5	35777956
Pubmed	Pih1d3 is required for cytoplasmic preassembly of axonemal dynein in mouse sperm.	DNAH9 DNAH7	1.93e-04	11	66	2	24421334
Pubmed	Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.	GBF1 DCUN1D5 SUGP2 PI4KA RBPJ SNX33 ECPAS CHUK	2.14e-04	857	66	8	25609649
Pubmed	PRISMA and BioID disclose a motifs-based interactome of the intrinsically disordered transcription factor C/EBPα.	EPRS1 SUGP2 U2SURP CCAR1 PFKM ECPAS NSUN2 PHGDH RAD21	2.29e-04	1103	66	9	34189442
Pubmed	Notch signaling promotes nephrogenesis by downregulating Six2.	SLC12A1 RBPJ	2.31e-04	12	66	2	27633993
Pubmed	C-type natriuretic peptide (CNP) is a bifurcation factor for sensory neurons.	NPR2 GUCY1B1	2.31e-04	12	66	2	19805384
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	SUGP2 U2SURP CCAR1 NUP214 ECPAS NSUN2 RAD21	2.38e-04	653	66	7	22586326
Pubmed	SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation-Phosphorylation Cross-talk.	EPRS1 U2SURP TNRC6B NUP214 CPT1A NSUN2 PHGDH	2.42e-04	655	66	7	35819319
Pubmed	Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells.	GBF1 CCAR1 NUP214 XPNPEP1 PFKM ECPAS NSUN2 UBLCP1 PHGDH RAD21	2.42e-04	1367	66	10	32687490
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	EPRS1 SUGP2 GUCY1B1 PI4KA U2SURP TNRC6B PLPPR3 PHGDH RYR2	2.91e-04	1139	66	9	36417873
Pubmed	Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation.	TNRC6B TNRC6C	3.18e-04	14	66	2	19716330
Pubmed	ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure.	TIA1 SUGP2 TNRC6B NSUN2 RAD21	3.36e-04	315	66	5	26777405
Pubmed	GW182 proteins directly recruit cytoplasmic deadenylase complexes to miRNA targets.	TNRC6B TNRC6C	3.67e-04	15	66	2	21981923
Pubmed	Drafting the CLN3 protein interactome in SH-SY5Y human neuroblastoma cells: a label-free quantitative proteomics approach.	CPT1A ECPAS PHGDH	3.69e-04	73	66	3	23464991
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	EPRS1 U2SURP CCAR1 PFKM DNAH6 POFUT2 UBLCP1 RYR2 CHUK MYBPC1	3.70e-04	1442	66	10	35575683
Pubmed	Proteomic analysis of the epidermal growth factor receptor (EGFR) interactome and post-translational modifications associated with receptor endocytosis in response to EGF and stress.	SUGP2 PFKM ECPAS NSUN2 CPVL	3.77e-04	323	66	5	24797263
Pubmed	LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.	EPRS1 PI4KA RO60 NUP214 CPT1A ECPAS NSUN2 PHGDH	4.03e-04	942	66	8	31073040
Pubmed	Regulation of epidermal differentiation through KDF1-mediated deubiquitination of IKKα.	U2SURP PFKM NSUN2 CHUK	4.06e-04	182	66	4	32239614
Pubmed	Characterization of the EGFR interactome reveals associated protein complex networks and intracellular receptor dynamics.	EPRS1 GBF1 ITIH2 PHGDH	4.14e-04	183	66	4	23956138
Pubmed	Characterization of Dynamic UbR-Proteasome Subcomplexes by In vivo Cross-linking (X) Assisted Bimolecular Tandem Affinity Purification (XBAP) and Label-free Quantitation.	ECPAS UBLCP1 PHGDH	4.49e-04	78	66	3	27114451
Pubmed	Comprehensive analysis of low-abundance proteins in human urinary exosomes using peptide ligand library technology, peptide OFFGEL fractionation and nanoHPLC-chip-MS/MS.	SLC12A1 EGF	4.74e-04	17	66	2	21082674
Pubmed	The DNA sequence and comparative analysis of human chromosome 10.	GBF1 ZNF485 CCAR1 XPNPEP1 CHUK	5.08e-04	345	66	5	15164054
Pubmed	Characterization of the mammalian family of DCN-type NEDD8 E3 ligases.	RNF7 DCUN1D5	5.32e-04	18	66	2	26906416
Pubmed	Notch is required for the formation of all nephron segments and primes nephron progenitors for differentiation.	SLC12A1 RBPJ	5.32e-04	18	66	2	29113990
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	SELENOS SUGP2 CCAR1 TNRC6B NUP214 TNRC6C ECPAS	5.62e-04	754	66	7	33060197
Pubmed	C9orf72 protein quality control by UBR5-mediated heterotypic ubiquitin chains.	EPRS1 GBF1 TIA1 U2SURP TNRC6B PFKM CPT1A NSUN2 PHGDH	5.94e-04	1257	66	9	37317656
Pubmed	Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk.	NPR2 TNRC6B	5.94e-04	19	66	2	25342443
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	EPRS1 GBF1 PI4KA ECPAS	6.01e-04	202	66	4	33005030
Pubmed	Phospho-proteomic analyses of B-Raf protein complexes reveal new regulatory principles.	PI4KA ECPAS UBLCP1	6.60e-04	89	66	3	27034005
Pubmed	DNA sequence and analysis of human chromosome 9.	NPR2 GLIPR2 DELEC1 ECPAS RECK	6.96e-04	370	66	5	15164053
Pubmed	Identifying biological pathways that underlie primordial short stature using network analysis.	EPRS1 SUGP2 PI4KA U2SURP NUP214 NSUN2 PHGDH NRP1	6.97e-04	1024	66	8	24711643
Pubmed	The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.	MOXD1 SUGP2 CCAR1 CPT1A	7.20e-04	212	66	4	33853758
Pubmed	Systematically defining selective autophagy receptor-specific cargo using autophagosome content profiling.	DCUN1D5 U2SURP CCAR1 NUP214 PFKM CPT1A POFUT2 UBLCP1 PHGDH	7.42e-04	1297	66	9	33545068
Pubmed	Trinucleotide repeat containing 6a (Tnrc6a)-mediated microRNA function is required for development of yolk sac endoderm.	TNRC6B TNRC6C	7.99e-04	22	66	2	22187428
Pubmed	Deubiquitinating enzyme PSMD14 promotes tumor metastasis through stabilizing SNAIL in human esophageal squamous cell carcinoma.	EPRS1 U2SURP RO60 ECPAS PHGDH	8.13e-04	383	66	5	29331416
Pubmed	GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system.	EPRS1 U2SURP NSUN2 PHGDH	8.40e-04	221	66	4	29991511
Pubmed	Wnt regulation: exploring Axin-Disheveled interactions and defining mechanisms by which the SCF E3 ubiquitin ligase is recruited to the destruction complex.	EPRS1 DCUN1D5 U2SURP CCAR1 ECPAS NSUN2 PHGDH	8.50e-04	809	66	7	32129710
Pubmed	The receptor guanylyl cyclase Npr2 is essential for sensory axon bifurcation within the spinal cord.	NPR2 GUCY1B1	8.75e-04	23	66	2	17954614
Pubmed	Trinucleotide repeat containing 6c (TNRC6c) is essential for microvascular maturation during distal airspace sacculation in the developing lung.	TNRC6B TNRC6C	8.75e-04	23	66	2	28811219
Pubmed	FAF1 phosphorylation by AKT accumulates TGF-β type II receptor and drives breast cancer metastasis.	EPRS1 U2SURP ECPAS PHGDH	8.83e-04	224	66	4	28443643
Pubmed	Widespread and dynamic translational control of red blood cell development.	PI4KA XPNPEP1 NSUN2	9.80e-04	102	66	3	27899360
Pubmed	USP45 and Spindly are part of the same complex implicated in cell migration.	EPRS1 U2SURP CCAR1 PHGDH	1.05e-03	235	66	4	30258100
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	SUGP2 TNRC6B NUP214 TNRC6C CSMD3	1.07e-03	407	66	5	12693553
Pubmed	Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells.	EPRS1 NUP214 PFKM CPT1A CPVL PHGDH	1.09e-03	613	66	6	22268729
Pubmed	Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer.	EPRS1 TIA1 SUGP2 U2SURP CCAR1 CPT1A RAD21	1.11e-03	847	66	7	35850772
Pubmed	CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicity.	EPRS1 GBF1 CPT1A ECPAS PHGDH	1.20e-03	418	66	5	35338135
Pubmed	Loss of TRIM31 promotes breast cancer progression through regulating K48- and K63-linked ubiquitination of p53.	EPRS1 TIA1 U2SURP NSUN2 PHGDH	1.24e-03	421	66	5	34650049
Pubmed	A directed protein interaction network for investigating intracellular signal transduction.	EPRS1 MOXD1 POLR3D PI4KA RBPJ PINX1 XPNPEP1 PHGDH	1.27e-03	1124	66	8	21900206
Pubmed	Human Antiviral Protein IFIX Suppresses Viral Gene Expression during Herpes Simplex Virus 1 (HSV-1) Infection and Is Counteracted by Virus-induced Proteasomal Degradation.	SUGP2 U2SURP NSUN2 NRP1	1.34e-03	251	66	4	28077445
Pubmed	A genetic linkage map of mouse chromosome 2 extending from thrombospondin to paired box gene 1, including the H3 minor histocompatibility complex.	PCSK2 SLC12A1	1.39e-03	29	66	2	8617512
Pubmed	A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis.	EPRS1 SUGP2 U2SURP CCAR1	1.40e-03	254	66	4	28431233
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	PI4KA RBPJ CCAR1 TNRC6B PINX1 CPVL	1.41e-03	645	66	6	25281560
Pubmed	Network organization of the human autophagy system.	GBF1 CCAR1 CPT1A ECPAS CPVL	1.46e-03	437	66	5	20562859
Pubmed	HAND2 Target Gene Regulatory Networks Control Atrioventricular Canal and Cardiac Valve Development.	RBPJ GLIPR2	1.49e-03	30	66	2	28538179
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	GBF1 TNRC6B ECPAS CPVL RAD21	1.59e-03	446	66	5	24255178
Pubmed	A high-throughput approach for measuring temporal changes in the interactome.	EPRS1 GBF1 AKAP10 RO60 XPNPEP1 PFKM ECPAS NSUN2 CHUK	1.65e-03	1455	66	9	22863883
Pubmed	Salivary gland branching morphogenesis: a quantitative systems analysis of the Eda/Edar/NFkappaB paradigm.	EGF CHUK	1.70e-03	32	66	2	19500387
Pubmed	Genetic variations in humans associated with differences in the course of hepatitis C.	EGF CD80	1.70e-03	32	66	2	15063762
GeneFamily	Dyneins, axonemal	DNAH17 DNAH6 DNAH9 DNAH7	7.09e-08	17	44	4	536
GeneFamily	G-patch domain containing\|Minor histocompatibility antigens	SUGP2 PINX1	1.30e-03	22	44	2	579
GeneFamily	Ataxins\|Trinucleotide repeat containing	TNRC6B TNRC6C	1.68e-03	25	44	2	775
Coexpression	GSE7568_CTRL_VS_3H_TGFB_TREATED_MACROPHAGES_WITH_IL4_AND_DEXAMETHASONE_DN	ACTR8 TIA1 AKAP10 RO60 NUP214 ECPAS	4.05e-06	167	66	6	M361
CoexpressionAtlas	dev lower uro neuro_e15.5_PelvicGanglion_Sox10_k-means-cluster#4_top-relative-expression-ranked_500	GLIPR2 CSMD3 RYR2 NRP1	6.15e-06	41	62	4	gudmap_dev lower uro neuro_e15.5_PelvicGanglion_Sox10_k4_500
Drug	dibutyryl cyclic GMP	NPR2 SLC12A1 EGF GUCY1B1 PFKM MYBPC1	1.93e-06	130	65	6	CID000036095
Drug	AG-013608 [351320-38-2]; Down 200; 10uM; PC3; HT_HG-U133A	MOXD1 ACTR8 POLR3D NUP214 ECPAS ITIH2	1.87e-05	193	65	6	5909_DN
Drug	Myosmine [532-12-7]; Down 200; 27.4uM; MCF7; HT_HG-U133A	SUGP2 DNAH17 CPT1A DNAH7 ITIH2 RYR2	1.87e-05	193	65	6	3634_DN
Drug	Dorzolamide hydrochloride [130693-82-2]; Down 200; 11uM; PC3; HT_HG-U133A	NPR2 POLR3D EGF TNRC6B CPT1A RYR2	2.10e-05	197	65	6	5785_DN
Drug	Nicergoline; Down 200; 8.2uM; PC3; HT_HG-U133A	NPR2 EGF RO60 RECK RYR2 NRP1	2.10e-05	197	65	6	5775_DN
Drug	AC1NBU2S	NPR2 EGF GUCY1B1 RYR2 CHUK	2.12e-05	117	65	5	CID004473765
Drug	Nomegestrol acetate [58652-20-3]; Down 200; 10.8uM; PC3; HT_HG-U133A	EGF SUGP2 ECPAS POFUT2 RECK PHGDH	2.16e-05	198	65	6	6362_DN
Drug	Levocabastine hydrochloride [79547-78-7]; Down 200; 8.8uM; MCF7; HT_HG-U133A	GBF1 SUGP2 TNRC6B AKAP10 RO60 NUP214	2.22e-05	199	65	6	7009_DN
Disease	superior crus of antihelix expression	XPNPEP1 BANK1	4.49e-06	2	63	2	EFO_0007673
Disease	pappalysin‐1 measurement	PLPPR3 DELEC1 BANK1	3.26e-05	29	63	3	EFO_0010618
Disease	reticulocyte count	EPRS1 EGF U2SURP DNAH17 TNRC6B PLPPR3 AKAP10 PFKM NRP1	3.60e-04	1045	63	9	EFO_0007986
Disease	sensorineural hearing loss (implicated_via_orthology)	DNAH17 DNAH9	7.49e-04	19	63	2	DOID:10003 (implicated_via_orthology)
Disease	body composition measurement	MOXD1 TNRC6B PINX1 CPVL	7.82e-04	193	63	4	EFO_0005106
Disease	low density lipoprotein cholesterol measurement, free cholesterol:total lipids ratio	GBF1 PINX1 CPT1A BANK1	8.93e-04	200	63	4	EFO_0004611, EFO_0020945
Disease	energy expenditure	MOXD1 CPT1A	1.52e-03	27	63	2	EFO_0005109
Disease	Streptozotocin Diabetes	PCSK2 PFKM CPT1A	1.61e-03	108	63	3	C0038433
Disease	Diabetes Mellitus, Experimental	PCSK2 PFKM CPT1A	1.61e-03	108	63	3	C0011853
Disease	Alloxan Diabetes	PCSK2 PFKM CPT1A	1.61e-03	108	63	3	C0002152
Disease	reticulocyte measurement	EGF U2SURP DNAH17 TNRC6B PLPPR3 PFKM ECPAS MYBPC1	1.74e-03	1053	63	8	EFO_0010700
Disease	osteoarthritis, hip, body mass index	DELEC1 BANK1	1.88e-03	30	63	2	EFO_0004340, EFO_1000786

Protein segments in the cluster

Peptide	Gene	Start	Entry
SGATWASKMKNMEGS	BANK1	366	Q8NDB2
QKSKEGTGRVVMWKM	AGBL3	511	Q8NEM8
SVKKMKEENWAMDGF	CSMD3	3566	Q7Z407
MKGKDEAMAIGGHWS	CCAR1	491	Q8IX12
KGSMFSQAMKKWVQG	AKAP10	611	O43572
KMVDQAIWSKKMSNG	ACTR8	111	Q9H981
GKMSRATKIWMGMVK	CPT1A	141	P50416
GDVEMKGKGKMRTYW	NPR2	1021	P20594
WQKEKKMVLTMMSGD	CD80	66	P33681
ESMGFFTKEEWLKGM	DCUN1D5	96	Q9BTE7
GDKMFSLKKWNAVAM	RNF7	26	Q9UBF6
GKAFADMMGKVDVWK	RAMP3	41	O60896
MMWKETGGVEKLFSL	RAD21	361	O60216
QGAMNDMKLWEKGSI	RECK	376	O95980
KWMPGITQWKVMTKD	NSUN2	356	Q08J23
DVSGSMWGVKMKQTV	ITIH2	316	P19823
MWGVKMKQTVEAMKT	ITIH2	321	P19823
GISSEKMLKAWKEME	CHUK	501	O15111
GKMKDWERLVATAMK	DHRS4L1	91	P0CG22
MSVIWEKGVHSGKMD	DPYS	356	Q14117
MGMDWKGSQEYKKAE	CPVL	401	Q9H3G5
WKMKAQGAIAMASIA	ECPAS	1541	Q5VYK3
ATKMGAKAMNWMSGK	PFKM	676	P08237
AKAMNWMSGKIKESY	PFKM	681	P08237
DSKFGQRMLEKMGWS	PINX1	26	Q96BK5
QRMLEKMGWSKGKGL	PINX1	31	Q96BK5
VMIMGGKMEATPFKW	PI4KA	2001	P42356
KDAGGMVIDMKWNPT	NUP214	146	P35658
SMKGKKEPMQVWFLS	GUCY1B1	591	Q02153
NNGSDWKMIMDDSKR	NRP1	521	O14786
IAEKMVKDAMKSGNW	DNAH6	3581	Q9C0G6
DKSWKAAKIMMGKVD	DNAH17	3181	Q9UFH2
MKTIWIANKHTGKDM	EGF	266	P01133
AMVWKNTKKMGVGKA	GLIPR2	106	Q9H4G4
MTMNVLEAGKWKSIV	DELEC1	1	Q9P2X7
AMKMLEKAVKEGTWV	DNAH7	3471	Q8WXX0
MRAGGMSDSSKWKKQ	GBF1	216	Q92538
WDKMLQKGMKKSVGL	FAAH	531	O00519
MGMEKTLKELQTTWA	DNAH9	1431	Q9NYC9
GQVDVEKWKFMMKTA	RYR2	91	Q92736
EKWKFMMKTAQGGGH	RYR2	96	Q92736
DVKGGFMKWMSRMQT	OR1Q1	296	Q15612
QGPAEMMKKKGNWDK	POLR3D	111	P05423
MMKKKGNWDKTVDVS	POLR3D	116	P05423
IEKNLQMWEEMKKGS	EPRS1	316	P07814
QMWEEMKKGSQFGQS	EPRS1	321	P07814
KGMKTSGKQDEAWIM	TNRC6C	926	Q9HCJ0
KMDGMTEWGNVKPSV	PUS3	381	Q9BZE2
EDWMKMKVKLGSALG	POFUT2	271	Q9Y2G5
WKMGKRRAEKDEMVG	SNX33	341	Q8WV41
KEMNSGMAKKQAWLI	SLC12A1	726	Q13621
FKKDLKESMKCGMWG	RO60	131	P10155
DLANWMIPGKKVKGM	OXCT2	406	Q9BYC2
KMIMSFEMKLGWGKA	U2SURP	341	O15042
IEMWDSMQEGKSYKG	SELENOS	116	Q9BQE4
MGEKNGDAKTFWMEL	SETDB2	1	Q96T68
KAMNWKESFQMGSKS	USP43	951	Q70EL4
MDSNWTLMKMGLKDT	XPNPEP1	86	Q9NQW7
MDWGKVAFKNFSGEM	UBTFL1	41	P0CB47
MDAMNKFKWTKKEGL	MOXD1	521	Q6UVY6
SGAGVRAKWLMMAEK	PLPPR3	511	Q6T4P5
DKNLGFQMLQKMGWK	SUGP2	1011	Q8IX01
KETIGKISAASKMMW	VWA2	31	Q5GFL6
MGSGWKKKKEQMERD	RBPJ	76	Q06330
NMKWIEAKMKELGVS	UBLCP1	186	Q8WVY7
ASMKDGKWERKKFMG	PHGDH	126	O43175
GGRDKMVKVWDMTTH	WDR24	226	Q96S15
GERTKSVMMEKGLDW	ZNF485	106	Q8NCK3
MNGRKIMGKEVKVNW	TIA1	66	P31483
MKPNSKSMQDGWGES	TNRC6B	986	Q9UPQ9
KAMWSRGDKAIMEGS	MYBPC1	556	Q00872
VLDAGAMVKMAKDWK	PCSK2	446	P16519