Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	cGAS/STING signaling pathway	PARP1 SLC19A1 PRKDC	2.31e-05	19	61	3	GO:0140896
GeneOntologyBiologicalProcess	DNA replication	ERVK-6 PARP1 SMC3 EHMT2 ERVK-8 MCM6 REPIN1	3.67e-05	312	61	7	GO:0006260
GeneOntologyCellularComponent	nuclear chromosome	PARP1 SMC3 RNF212 SAP30L MCM6 SAP30	9.63e-05	254	61	6	GO:0000228
GeneOntologyCellularComponent	chromatin	HOXA3 KANSL1L PARP1 HOXC8 SMC3 EHMT2 SAP30L FAM47C CHD6 PRKDC NKX3-1 SAP30 THAP11	2.84e-04	1480	61	13	GO:0000785
Domain	Tensin_PTB	TNS2 TNS1 TNS3	1.32e-07	4	61	3	IPR033929
Domain	PTEN_C2	TNS2 TNS1 TNS3	1.83e-06	8	61	3	SM01326
Domain	PTEN_C2	TNS2 TNS1 TNS3	1.83e-06	8	61	3	PF10409
Domain	PTB	TNS2 TNS1 TNS3	1.83e-06	8	61	3	PF08416
Domain	PTB	TNS2 TNS1 TNS3	1.83e-06	8	61	3	IPR013625
Domain	C2_TENSIN	TNS2 TNS1 TNS3	1.83e-06	8	61	3	PS51182
Domain	Tensin_lipid_phosphatase_dom	TNS2 TNS1 TNS3	1.83e-06	8	61	3	IPR029023
Domain	Tensin_C2-dom	TNS2 TNS1 TNS3	1.83e-06	8	61	3	IPR014020
Domain	PPASE_TENSIN	TNS2 TNS1 TNS3	2.75e-06	9	61	3	PS51181
Domain	SAP30_Sin3-bd	SAP30L SAP30	1.05e-05	2	61	2	IPR025718
Domain	SAP30_zn-finger	SAP30L SAP30	1.05e-05	2	61	2	IPR025717
Domain	SAP30_Sin3_bdg	SAP30L SAP30	1.05e-05	2	61	2	PF13867
Domain	zf-SAP30	SAP30L SAP30	1.05e-05	2	61	2	PF13866
Domain	His_deAcase_SAP30/SAP30L	SAP30L SAP30	1.05e-05	2	61	2	IPR024145
Domain	FAM47	FAM47C FAM47B	6.27e-05	4	61	2	PF14642
Domain	FAM47	FAM47C FAM47B	6.27e-05	4	61	2	IPR032743
Domain	-	PTPN12 TNS2 TNS1 TNS3	2.32e-04	92	61	4	3.90.190.10
Domain	PTB	TNS2 TNS1 TNS3	3.00e-04	40	61	3	SM00462
Domain	Prot-tyrosine_phosphatase-like	PTPN12 TNS2 TNS1 TNS3	3.07e-04	99	61	4	IPR029021
Domain	PTB/PI_dom	TNS2 TNS1 TNS3	3.23e-04	41	61	3	IPR006020
Domain	SH2	TNS2 SH2D7 TNS1 TNS3	3.32e-04	101	61	4	PF00017
Domain	SH2	TNS2 SH2D7 TNS1 TNS3	4.59e-04	110	61	4	SM00252
Domain	SH2	TNS2 SH2D7 TNS1 TNS3	4.75e-04	111	61	4	PS50001
Domain	SH2	TNS2 SH2D7 TNS1 TNS3	4.91e-04	112	61	4	IPR000980
Domain	-	TNS2 SH2D7 TNS1 TNS3	4.91e-04	112	61	4	3.30.505.10
Domain	PTPc_motif	PTPN12 TNS1 TNS3	9.46e-04	59	61	3	SM00404
Domain	Tyr_Pase_cat	PTPN12 TNS1 TNS3	9.46e-04	59	61	3	IPR003595
Domain	Retrov_capsid_C	ERVK-6 ZNF394 ZSCAN5DP	9.46e-04	59	61	3	IPR008916
Domain	HTH_motif	HOXA3 HOXC8 NKX3-1	1.49e-03	69	61	3	IPR000047
Domain	LH2	LIPC ALOX12B	1.55e-03	18	61	2	SM00308
Domain	C2_dom	TNS2 UNC13C TNS1 TNS3	2.03e-03	164	61	4	IPR000008
Domain	PLAT	LIPC ALOX12B	2.12e-03	21	61	2	PS50095
Domain	-	LIPC ALOX12B	2.12e-03	21	61	2	2.60.60.20
Domain	Homeobox_Antennapedia_CS	HOXA3 HOXC8	2.12e-03	21	61	2	IPR001827
Domain	PLAT	LIPC ALOX12B	2.12e-03	21	61	2	PF01477
Domain	PLAT/LH2_dom	LIPC ALOX12B	2.12e-03	21	61	2	IPR001024
Domain	ANTENNAPEDIA	HOXA3 HOXC8	2.77e-03	24	61	2	PS00032
Domain	Homeobox_metazoa	HOXA3 HOXC8 NKX3-1	3.18e-03	90	61	3	IPR020479
Pubmed	Aire's partners in the molecular control of immunological tolerance.	PARP1 SMC3 MCM6 CHD6 PRKDC	1.77e-08	45	62	5	20085707
Pubmed	Tensin3 is a negative regulator of cell migration and all four Tensin family members are downregulated in human kidney cancer.	TNS2 TNS1 TNS3	2.16e-08	4	62	3	19194507
Pubmed	The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1.	TNS2 TNS1 TNS3	5.38e-08	5	62	3	17190795
Pubmed	Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1.	PARP1 SMC3 EHMT2 PRKDC SYMPK	2.10e-06	116	62	5	21549307
Pubmed	Mouse homeobox gene transcripts occupy different but overlapping domains in embryonic germ layers and organs: a comparison of Hox-3.1 and Hox-1.5.	HOXA3 HOXC8	3.13e-06	2	62	2	2904354
Pubmed	Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration.	TNS2 TNS1	3.13e-06	2	62	2	11792844
Pubmed	Germline mutation rates at tandem repeat loci in DNA-repair deficient mice.	PARP1 PRKDC	3.13e-06	2	62	2	15450426
Pubmed	DNA damage-induced inhibition of rRNA synthesis by DNA-PK and PARP-1.	PARP1 PRKDC	3.13e-06	2	62	2	23775790
Pubmed	Tensin Regulates Fundamental Biological Processes by Interacting with Integrins of Tonsil-Derived Mesenchymal Stem Cells.	TNS1 TNS3	3.13e-06	2	62	2	35954177
Pubmed	Impact of PARP-1 and DNA-PK expression on survival in patients with glioblastoma multiforme.	PARP1 PRKDC	3.13e-06	2	62	2	21775006
Pubmed	Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis.	PARP1 PRKDC	3.13e-06	2	62	2	9398855
Pubmed	Effects of novel inhibitors of poly(ADP-ribose) polymerase-1 and the DNA-dependent protein kinase on enzyme activities and DNA repair.	PARP1 PRKDC	3.13e-06	2	62	2	15286704
Pubmed	Suppression of the poly(ADP-ribose) polymerase activity by DNA-dependent protein kinase in vitro.	PARP1 PRKDC	3.13e-06	2	62	2	10467406
Pubmed	PARP1 and DNA-PKcs synergize to suppress p53 mutation and telomere fusions during T-lineage lymphomagenesis.	PARP1 PRKDC	3.13e-06	2	62	2	22614020
Pubmed	Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs.	PARP1 PRKDC	9.37e-06	3	62	2	15545322
Pubmed	DNA-PKcs and PARP1 Bind to Unresected Stalled DNA Replication Forks Where They Recruit XRCC1 to Mediate Repair.	PARP1 PRKDC	9.37e-06	3	62	2	26603896
Pubmed	Homeotic transformations of murine vertebrae and concomitant alteration of Hox codes induced by retinoic acid.	HOXA3 HOXC8	9.37e-06	3	62	2	1680565
Pubmed	Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS.	PARP1 PRKDC	9.37e-06	3	62	2	35460603
Pubmed	p53 deficiency does not affect mutation rate in the mouse germline.	PARP1 PRKDC	9.37e-06	3	62	2	15806156
Pubmed	DNA repair proteins cooperate with SOX2 in regulating the transition of human embryonic stem cells to neural progenitor cells.	PARP1 PRKDC	9.37e-06	3	62	2	34852960
Pubmed	DNA-binding and -bending activities of SAP30L and SAP30 are mediated by a zinc-dependent module and monophosphoinositides.	SAP30L SAP30	9.37e-06	3	62	2	19015240
Pubmed	Identification of an NKX3.1-G9a-UTY transcriptional regulatory network that controls prostate differentiation.	EHMT2 NKX3-1	9.37e-06	3	62	2	27339988
Pubmed	CPP32/Yama/apopain cleaves the catalytic component of DNA-dependent protein kinase in the holoenzyme.	PARP1 PRKDC	9.37e-06	3	62	2	8804412
Pubmed	Synthetic Lethal and Resistance Interactions with BET Bromodomain Inhibitors in Triple-Negative Breast Cancer.	PRPF31 DNAJB1 CACTIN PARP1 SMC3 EHMT2 MCM6 PRKDC SAP30 SYMPK	1.15e-05	1014	62	10	32416067
Pubmed	LRF maintains genome integrity by regulating the non-homologous end joining pathway of DNA repair.	PARP1 SMC3 EHMT2 PRKDC	1.24e-05	79	62	4	26446488
Pubmed	The functional interactome landscape of the human histone deacetylase family.	SMC3 EHMT2 UTP4 SAP30L PRKDC SAP30	1.30e-05	289	62	6	23752268
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	GPD2 DNAJB1 CACTIN PARP1 PTPN12 IFT57 TNS2 TNS1 TNS3 SYMPK	1.55e-05	1049	62	10	27880917
Pubmed	Granzyme B directly and efficiently cleaves several downstream caspase substrates: implications for CTL-induced apoptosis.	PARP1 PRKDC	1.87e-05	4	62	2	9586635
Pubmed	Regulation of phospholipase D activity and phosphatidic acid production after purinergic (P2Y6) receptor stimulation.	P2RY6 PLD1	1.87e-05	4	62	2	23723068
Pubmed	DNA-Dependent protein kinase is not required for efficient lentivirus integration.	PARP1 PRKDC	1.87e-05	4	62	2	11070027
Pubmed	Inactivation of Pde8b enhances memory, motor performance, and protects against age-induced motor coordination decay.	PDE8B MICU2	1.87e-05	4	62	2	22925203
Pubmed	Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death.	PARP1 PRKDC	1.87e-05	4	62	2	8642305
Pubmed	The CRL4DCAF6 E3 ligase ubiquitinates CtBP1/2 to induce apoptotic signalling and promote intervertebral disc degeneration.	EHMT2 PISD PLD1 SAP30 THAP11	2.90e-05	199	62	5	36688959
Pubmed	BMI1 confers radioresistance to normal and cancerous neural stem cells through recruitment of the DNA damage response machinery.	PARP1 PRKDC	3.12e-05	5	62	2	20668194
Pubmed	Differential requirement for H2AX and 53BP1 in organismal development and genome maintenance in the absence of poly(ADP)ribosyl polymerase 1.	PARP1 PRKDC	3.12e-05	5	62	2	20231360
Pubmed	Inactivation of tensin3 in mice results in growth retardation and postnatal lethality.	TNS1 TNS3	3.12e-05	5	62	2	15733665
Pubmed	A role for the HOXB7 homeodomain protein in DNA repair.	PARP1 PRKDC	3.12e-05	5	62	2	17308091
Pubmed	Association of the Ku autoantigen/DNA-dependent protein kinase holoenzyme and poly(ADP-ribose) polymerase with the DNA binding domain of progesterone receptors.	PARP1 PRKDC	3.12e-05	5	62	2	10750018
Pubmed	53BP1 mediates the fusion of mammalian telomeres rendered dysfunctional by DNA-PKcs loss or inhibition.	PARP1 PRKDC	3.12e-05	5	62	2	25264618
Pubmed	Elevated DNA double strand breaks and apoptosis in the CNS of scid mutant mice.	PARP1 PRKDC	3.12e-05	5	62	2	11319607
Pubmed	Poly(ADP-ribose) Polymerase 1 Interacts with Nuclear Respiratory Factor 1 (NRF-1) and Plays a Role in NRF-1 Transcriptional Regulation.	PARP1 PRKDC	4.67e-05	6	62	2	19181665
Pubmed	SAP30L interacts with members of the Sin3A corepressor complex and targets Sin3A to the nucleolus.	SAP30L SAP30	4.67e-05	6	62	2	16820529
Pubmed	Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling.	PARP1 PRKDC	4.67e-05	6	62	2	22504299
Pubmed	TNKS1BP1 functions in DNA double-strand break repair though facilitating DNA-PKcs autophosphorylation dependent on PARP-1.	PARP1 PRKDC	4.67e-05	6	62	2	25749521
Pubmed	TRIM33 drives prostate tumor growth by stabilizing androgen receptor from Skp2-mediated degradation.	PARP1 SMC3 PRKDC NKX3-1 SYMPK	4.67e-05	220	62	5	35785414
Pubmed	MYC multimers shield stalled replication forks from RNA polymerase.	GPD2 PRPF31 DNAJB1 PARP1 SMC3 UTP4 MCM6 PRKDC SYMPK	6.16e-05	989	62	9	36424410
Pubmed	Differential requirements of androgen receptor in luminal progenitors during prostate regeneration and tumor initiation.	PRKDC NKX3-1	6.53e-05	7	62	2	29334357
Pubmed	Nuclear receptor coactivator thyroid hormone receptor-binding protein (TRBP) interacts with and stimulates its associated DNA-dependent protein kinase.	PARP1 PRKDC	6.53e-05	7	62	2	12519782
Pubmed	A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription.	PARP1 PRKDC	6.53e-05	7	62	2	16794079
Pubmed	Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes.	EHMT2 SAP30L SAP30	7.26e-05	45	62	3	21258344
Pubmed	HiPLA: High-throughput imaging proximity ligation assay.	DNAJB1 PARP1 EHMT2	7.75e-05	46	62	3	30419336
Pubmed	The Tumor Suppressor CIC Directly Regulates MAPK Pathway Genes via Histone Deacetylation.	PRPF31 PARP1 SMC3 EHMT2 SAP30L PRKDC SAP30	7.95e-05	583	62	7	29844126
Pubmed	The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.	GPD2 PRPF31 PARP1 UTP4 WLS REPIN1	7.96e-05	400	62	6	35013556
Pubmed	EVI1 oncoprotein interacts with a large and complex network of proteins and integrates signals through protein phosphorylation.	PARP1 SMC3 EHMT2 PRKDC	8.28e-05	128	62	4	23858473
Pubmed	Mouse Hox-3.4: homeobox sequence and embryonic expression patterns compared with other members of the Hox gene network.	HOXA3 HOXC8	8.69e-05	8	62	2	1976088
Pubmed	Wnt signaling though beta-catenin is required for prostate lineage specification.	PRKDC NKX3-1	8.69e-05	8	62	2	22960283
Pubmed	Ku is a novel transcriptional recycling coactivator of the androgen receptor in prostate cancer cells.	PARP1 PRKDC	8.69e-05	8	62	2	15640154
Pubmed	H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.	PRPF31 CACTIN PARP1 EHMT2 UTP4 SAP30L CHD6 PRKDC SAP30 SYMPK	9.07e-05	1294	62	10	30804502
Pubmed	Transcription factor protein interactomes reveal genetic determinants in heart disease.	WDR91 DNAJB1 SMC3 EHMT2 PRKDC REPIN1	9.23e-05	411	62	6	35182466
Pubmed	The in vivo Interaction Landscape of Histones H3.1 and H3.3.	PRPF31 CACTIN PARP1 SMC3 EHMT2 UTP4 CHD6	1.03e-04	608	62	7	36089195
Pubmed	BAP1 regulation of the key adaptor protein NCoR1 is critical for γ-globin gene repression.	PRPF31 DNAJB1 CACTIN PARP1 SMC3 UTP4 MCM6 CHD6 PRKDC THAP11	1.06e-04	1318	62	10	30463901
Pubmed	The polycomb group protein L3mbtl2 assembles an atypical PRC1-family complex that is essential in pluripotent stem cells and early development.	PARP1 SMC3 EHMT2	1.06e-04	51	62	3	22770845
Pubmed	Altered cellular proliferation and mesoderm patterning in Polycomb-M33-deficient mice.	HOXA3 HOXC8	1.12e-04	9	62	2	9043087
Pubmed	Pellino1 specifically binds to phospho-Thr18 of p53 and is recruited to sites of DNA damage.	PARP1 PRKDC	1.12e-04	9	62	2	30987826
Pubmed	An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits.	TBC1D8 WLS	1.39e-04	10	62	2	20548944
Pubmed	A role of DNA-PK for the metabolic gene regulation in response to insulin.	PARP1 PRKDC	1.39e-04	10	62	2	19303849
Pubmed	Cognate homeo-box loci mapped on homologous human and mouse chromosomes.	HOXA3 HOXC8	1.70e-04	11	62	2	2878432
Pubmed	FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16.	PARP1 PRKDC	1.70e-04	11	62	2	18406329
Pubmed	Interaction of human minichromosome maintenance protein-binding protein with minichromosome maintenance 2-7.	SMC3 MCM6	2.04e-04	12	62	2	24299456
Pubmed	The NuRD complex cooperates with DNMTs to maintain silencing of key colorectal tumor suppressor genes.	PARP1 EHMT2	2.04e-04	12	62	2	23708667
Pubmed	USP13 interacts with cohesin and regulates its ubiquitination in human cells.	PRPF31 SMC3	2.04e-04	12	62	2	33334891
Pubmed	Concordant and opposite roles of DNA-PK and the "facilitator of chromatin transcription" (FACT) in DNA repair, apoptosis and necrosis after cisplatin.	PARP1 PRKDC	2.04e-04	12	62	2	21679440
Pubmed	Genomewide screening for fusogenic human endogenous retrovirus envelopes identifies syncytin 2, a gene conserved on primate evolution.	ERVK-6 ERVK-8	2.04e-04	12	62	2	14557543
Pubmed	Family with sequence similarity 60A (FAM60A) protein is a cell cycle-fluctuating regulator of the SIN3-HDAC1 histone deacetylase complex.	SAP30L PRKDC SAP30	2.08e-04	64	62	3	22865885
Pubmed	Interactions of the human MCM-BP protein with MCM complex components and Dbf4.	SMC3 MCM6	2.41e-04	13	62	2	22540012
Pubmed	Tshz1 is required for axial skeleton, soft palate and middle ear development in mice.	HOXA3 HOXC8	2.41e-04	13	62	2	17586487
Pubmed	KAP1 facilitates reinstatement of heterochromatin after DNA replication.	PRPF31 SMC3 EHMT2 UTP4 MCM6 PRKDC SAP30	2.53e-04	704	62	7	29955894
Pubmed	UHRF2 commissions the completion of DNA demethylation through allosteric activation by 5hmC and K33-linked ubiquitination of XRCC1.	PARP1 PRKDC	2.81e-04	14	62	2	34111398
Pubmed	Promoting anti-tumor immunity by targeting TMUB1 to modulate PD-L1 polyubiquitination and glycosylation.	SMC3 MCM6 PRKDC	2.95e-04	72	62	3	36376293
Pubmed	TIF1γ inhibits lung adenocarcinoma EMT and metastasis by interacting with the TAF15/TBP complex.	PARP1 SMC3 MCM6 PRKDC	3.00e-04	179	62	4	36261009
Pubmed	Enhanced prediction of Src homology 2 (SH2) domain binding potentials using a fluorescence polarization-derived c-Met, c-Kit, ErbB, and androgen receptor interactome.	TNS2 TNS1 TNS3	3.07e-04	73	62	3	24728074
Pubmed	Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event.	PRPF31 SMC3 MCM6 PRKDC	3.19e-04	182	62	4	26527279
Pubmed	GIAT4RA functions as a tumor suppressor in non-small cell lung cancer by counteracting Uchl3-mediated deubiquitination of LSH.	PARP1 PRKDC	3.23e-04	15	62	2	31417184
Pubmed	Phosphorylation of thyroid hormone receptor-associated nuclear receptor corepressor holocomplex by the DNA-dependent protein kinase enhances its histone deacetylase activity.	PARP1 PRKDC	3.23e-04	15	62	2	17242407
Pubmed	Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1.	PARP1 PRKDC	3.23e-04	15	62	2	19661379
Pubmed	Hoxc8 initiates an ectopic mammary program by regulating Fgf10 and Tbx3 expression and Wnt/β-catenin signaling.	HOXA3 HOXC8	3.23e-04	15	62	2	26459221
Pubmed	A Human Tyrosine Phosphatase Interactome Mapped by Proteomic Profiling.	DNAJB1 PTPN12 SMC3 TNS2 MCM6 PRKDC SIL1 TNS3	3.26e-04	974	62	8	28675297
Pubmed	Purification of proteins associated with specific genomic Loci.	PARP1 MCM6 PRKDC	3.46e-04	76	62	3	19135898
Pubmed	Comprehensive binary interaction mapping of SH2 domains via fluorescence polarization reveals novel functional diversification of ErbB receptors.	TNS2 TNS1 TNS3	3.59e-04	77	62	3	22973453
Pubmed	Homeotic transformations of the axial skeleton of YY1 mutant mice and genetic interaction with the Polycomb group gene Ring1/Ring1A.	HOXA3 HOXC8	3.69e-04	16	62	2	16624538
Pubmed	Isolation and characterization of a novel H1.2 complex that acts as a repressor of p53-mediated transcription.	PARP1 PRKDC	3.69e-04	16	62	2	18258596
Pubmed	Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler.	PARP1 PRKDC	3.69e-04	16	62	2	19666485
Pubmed	Nonsyndromic Retinitis Pigmentosa Overview	CERKL PRPF31 CA4	4.17e-04	81	62	3	20301590
Pubmed	FEZ1 dimerization and interaction with transcription regulatory proteins involves its coiled-coil region.	SMC3 SAP30L	4.70e-04	18	62	2	16484223
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	GPD2 SMC3 UTP4 MCM6 SYMPK THAP11	4.86e-04	560	62	6	35241646
Pubmed	Simultaneous mutation detection in 90 retinal disease genes in multiple patients using a custom-designed 300-kb retinal resequencing chip.	CERKL PRPF31 CA4	5.14e-04	87	62	3	20801516
Pubmed	Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2.	SMC3 MCM6 PRKDC	5.14e-04	87	62	3	17148452
Pubmed	The death-associated protein DAXX is a novel histone chaperone involved in the replication-independent deposition of H3.3.	PARP1 PRKDC	5.24e-04	19	62	2	20504901
Pubmed	Meiotic homologue alignment and its quality surveillance are controlled by mouse HORMAD1.	PARP1 SMC3	5.24e-04	19	62	2	21478856
Pubmed	Non-canonical function of DGCR8 in DNA double-strand break repair signaling and tumor radioresistance.	PARP1 PRKDC	5.24e-04	19	62	2	34188037
Interaction	AIRE interactions	PARP1 SMC3 MCM6 CHD6 PRKDC ALOX12B	4.77e-07	97	61	6	int:AIRE
Cytoband	Xp21.1	FAM47C FAM47B FAM47DP	1.43e-05	34	63	3	Xp21.1
Cytoband	Ensembl 112 genes in cytogenetic band chrXp21	FAM47C FAM47B FAM47DP	2.17e-04	84	63	3	chrXp21
GeneFamily	DNAJ (HSP40) heat shock proteins\|C2 tensin-type domain containing	TNS2 TNS1 TNS3	8.00e-07	8	45	3	837
GeneFamily	C2 tensin-type domain containing\|PTEN protein phosphatases\|Phosphoinositide phosphatases	TNS2 TNS1	6.03e-05	5	45	2	902
GeneFamily	SH2 domain containing	TNS2 SH2D7 TNS1 TNS3	1.15e-04	101	45	4	741
Coexpression	ABRAMSON_INTERACT_WITH_AIRE	PARP1 SMC3 MCM6 CHD6 PRKDC	5.38e-08	44	60	5	M2536
Coexpression	GSE18281_SUBCAPSULAR_VS_PERIMEDULLARY_CORTICAL_REGION_OF_THYMUS_UP	LIPC P2RY6 TNS2 PISD PLD1 THAP11	6.51e-06	200	60	6	M7235
Coexpression	GSE36095_WT_VS_HDAC9_KO_TREG_DN	PTPN12 LIPC SLC45A3 SLC19A1 ITGA10	9.32e-06	123	60	5	M8936
Coexpression	FLECHNER_PBL_KIDNEY_TRANSPLANT_REJECTED_VS_OK_UP	PARP1 PTPN12 MCM6 REEP5	1.51e-05	65	60	4	M10243
Coexpression	GSE14415_ACT_TCONV_VS_ACT_NATURAL_TREG_DN	GPD2 PTPN12 SMC3 REEP5 SAP30	5.51e-05	178	60	5	M2950
Coexpression	GSE3982_DC_VS_EFF_MEMORY_CD4_TCELL_UP	TBC1D8 SLC19A1 TNS1 SIL1 TNS3	9.34e-05	199	60	5	M5474
Coexpression	GSE14308_TH2_VS_NAIVE_CD4_TCELL_DN	ST6GALNAC1 GPD2 ZNF394 ITGA10 SAP30L	9.56e-05	200	60	5	M3365
Coexpression	GSE9037_CTRL_VS_LPS_4H_STIM_IRAK4_KO_BMDM_DN	GPD2 PTPN12 IFT57 UTP4 SAP30	9.56e-05	200	60	5	M5811
Coexpression	GSE22443_NAIVE_VS_ACT_AND_IL2_TREATED_CD8_TCELL_UP	DNAJB1 GSTA5 PLD1 C6orf136 ALOX12B	9.56e-05	200	60	5	M8222
Coexpression	GSE9960_GRAM_POS_VS_GRAM_NEG_AND_POS_SEPSIS_PBMC_UP	PARP1 SMC3 PCSK7 PISD PRKDC	9.56e-05	200	60	5	M7132
Coexpression	GSE17721_4_VS_24H_CPG_BMDC_DN	DNAJB1 HOXC8 IFT57 C6orf136 SIL1	9.56e-05	200	60	5	M4131
Coexpression	GAUCHER_PBMC_YF_VAX_STAMARIL_UNKNOWN_AGE_10DY_DN	PRKDC WLS TNS1 CA4	1.04e-04	106	60	4	M41161
Coexpression	KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP	GPD2 DNAJB1 PARP1 SMC3 SLC19A1 UTP4 MCM6 PISD PRKDC TNS1 C6orf136	1.46e-04	1290	60	11	M80
ToppCell	3'-Child09-12-SmallIntestine-Epithelial-Tuft-related-Tuft\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HOXA3 SERPINA11 CPLX3 SH2D7 ALOX12B	3.54e-06	169	61	5	05e12524d68d409fed386ffad233305683b4575b
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-Tuft-related-Tuft\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HOXA3 SERPINA11 CPLX3 SH2D7 ALOX12B	4.56e-06	178	61	5	f17c3b7bb562ac24c6a03fe3c9ba94c2b434c141
ToppCell	3'-Pediatric_IBD-SmallIntestine-Epithelial-Tuft-related\|Pediatric_IBD / Celltypes from developing, pediatric, Crohn's, & adult GI tract	SERPINA11 CPLX3 SH2D7 ALOX12B CA4	5.21e-06	183	61	5	263937906ddabc798bbe60f0da28ba859a5c72e2
ToppCell	3'-Child09-12-SmallIntestine-Epithelial-Tuft-related\|Child09-12 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HOXA3 SERPINA11 SH2D7 ALOX12B CA4	5.50e-06	185	61	5	01d0e848d8ede2745cfb10b070e2d9674ef4d477
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-Tuft-related\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	HOXA3 SERPINA11 SH2D7 ALOX12B CA4	6.58e-06	192	61	5	d6ea34391c3f730684b82e912d9cf55e928b3311
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Vascular-Mural_cell-Pericyte-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	PDE8B ITGA10 TNS2 TNS3 CA4	7.46e-06	197	61	5	2872a78b1be61aa1d50bc9a49294a21e922dc033
Disease	cholesteryl esters:total lipids ratio, intermediate density lipoprotein measurement	LIPC SLC45A3 PCSK7	1.05e-03	103	57	3	EFO_0008595, EFO_0020944
Disease	Retinitis Pigmentosa	CERKL PRPF31 CA4	1.08e-03	104	57	3	C0035334
Disease	Prostatic Neoplasms	PARP1 CHD6 PRKDC NKX3-1 ALOX12B SIL1	1.19e-03	616	57	6	C0033578
Disease	Malignant neoplasm of prostate	PARP1 CHD6 PRKDC NKX3-1 ALOX12B SIL1	1.19e-03	616	57	6	C0376358
Disease	TYPE 2 DIABETES MELLITUS	GPD2 LIPC	1.34e-03	28	57	2	125853
Disease	Type 2 diabetes mellitus	GPD2 LIPC	1.34e-03	28	57	2	cv:C0011860
Disease	lysophosphatidylethanolamine 18:1 measurement	LIPC UNC13C	1.98e-03	34	57	2	EFO_0010368
Disease	retinitis pigmentosa (is_implicated_in)	CERKL CA4	2.86e-03	41	57	2	DOID:10584 (is_implicated_in)
Disease	Malignant tumor of colon	PTPN12 SLC19A1 ALOX12B	3.63e-03	159	57	3	C0007102

Protein segments in the cluster

Peptide	Gene	Start	Entry
LPVHLLFLRFYKRDK	C6orf136	236	Q5SQH8
PSKYIAKRKHRRLRF	FAM47DP	26	A6NHR8
SERRKKLRFHPRQLY	EHMT2	641	Q96KQ7
KRAYRRQALRYHPDK	DNAJB1	21	P25685
RYFPAFEKVLKSHRQ	GSTA5	131	Q7RTV2
QRYKPFKQLHNRRLL	PARP1	846	P09874
PSKYFAKRKHRRLRF	FAM47C	26	Q5HY64
DIRRYLLFARQFKPK	MCM6	571	Q14566
RTRPLQSFHKRKLYR	KANSL1L	561	A0AUZ9
QSFHKRKLYRLSPTF	KANSL1L	566	A0AUZ9
LPSDIDRYKKRFHKF	GPD2	621	P43304
LEKEFHFNRYLCRPR	HOXA3	206	O43365
LRRAKRSVHFNDPKY	PCSK7	136	Q16549
SQTEPHSFRYKNRRK	PDE8B	401	O95263
PSKYFAKRKHRRLRF	FAM47B	26	Q8NA70
YHVRQEPRSKSKRLF	LIPC	326	P11150
TRHLKFYNEPIRDAK	ERVK-6	851	Q9BXR3
TLRSHFRDKYRLPKN	CPLX3	71	Q8WVH0
LRKSNLKAPSRHYFA	IFT57	61	Q9NWB7
DLLPKEEKLRHYFRY	CA4	206	P22748
DRPRVRKQTKHYNSF	CHD6	1046	Q8TD26
RNTSRPEFIKHLKRY	CERKL	461	Q49MI3
IIRLHKERYAFFPKD	ALOX12B	66	O75342
KEFLFNPYLTRKRRI	HOXC8	166	P31273
RKRIATLFFHYIKTP	IQUB	561	Q8NA54
LRLVHNEFFRRAKFK	ITGA10	1066	O75578
DKYRPRKPRFFNRVH	CACTIN	636	Q8WUQ7
FYFTQKKFRRRPHEL	P2RY6	301	Q15077
KNYDAALRKITFPHR	UTP4	321	Q969X6
SKLRYNPRFDKAFKH	SMC3	611	Q9UQE7
FRRNIRKFVPKHKSY	SLC9C1	1101	Q4G0N8
NTLRRYKRHFKLPTR	SAP30	156	O75446
FHRELLKYKAFIRIP	PLD1	126	Q13393
KRGQRKLHYKEFRRF	MICU2	241	Q8IYU8
KNRYKDILPFDHSRV	PTPN12	61	Q05209
LHPDFLRYMKNRFLR	ST6GALNAC1	491	Q9NSC7
LLRHFPYAQRQFLKL	SIL1	296	Q9H173
RKFSHQKYLSAPERA	NKX3-1	141	Q99801
LYKRIIRPFFLKHES	REEP5	136	Q00765
TDNQRKLFFRRHYPV	TNS3	1361	Q68CZ2
RKRFFALPYVDHFLR	MRPL47	196	Q9HD33
SLYHREKQVFLPKYR	SLC45A3	401	Q96JT2
KAFRHKPYLAAHRRI	REPIN1	466	Q9BWE0
FQEKHRKRLLAFYRE	RNF212	86	Q495C1
LFRHQRLHKGERPYK	ZNF394	456	Q53GI3
RAFRRPETLKYHQKT	ZSCAN5DP	471	P0CG00
KRIRPSFKEAALRAY	UNC13C	966	Q8NB66
LFLDKRLKPRQHYLD	SERPINA11	141	Q86U17
RYKRHYKLQTRPGFN	SAP30L	121	Q9HAJ7
RKRFRTLYHNLFGPK	TRPM3	601	Q9HCF6
HYRNLSEFFRRKLKP	PISD	161	Q9UG56
FFRAFFRLPRKEKLH	TBC1D8	286	O95759
LFLKRPKRSLFFNRD	SLC19A1	201	P41440
YHKKFRSPARDVIFR	TNS1	251	Q9HBL0
TRHLKFYNEPIRDAK	ERVK-8	851	P63133
HKFIRDKYSKRFPEL	PRPF31	111	Q8WWY3
PDKLRRLFFTYRKHK	SH2D7	436	A6NKC9
DLIFKRPSRQFQYLH	SYMPK	701	Q92797
KRLYSLALHPNAFKR	PRKDC	1061	P78527
KAFSRFRYLSRHKRT	ZNF443	511	Q9Y2A4
RRLHYEGLIFRFKFL	WLS	421	Q5T9L3
RPTIHKLKTSLFRFY	WDR91	81	A4D1P6
LHFYTFPKDAELRRL	THAP11	21	Q96EK4
TDNQRKLFFRRHYPV	TNS2	1326	Q63HR2