Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	glycerophospholipid flippase activity	MFSD2A ATP11B ATP8B2	3.54e-05	14	94	3	GO:0140333
GeneOntologyMolecularFunction	flippase activity	MFSD2A ATP11B ATP8B2	6.55e-05	17	94	3	GO:0140327
GeneOntologyMolecularFunction	RNA transmembrane transporter activity	SIDT2 SIDT1	6.56e-05	3	94	2	GO:0051033
GeneOntologyMolecularFunction	nucleic acid transmembrane transporter activity	SIDT2 SIDT1	6.56e-05	3	94	2	GO:0051032
GeneOntologyMolecularFunction	melatonin receptor activity	GPR50 MTNR1B	1.31e-04	4	94	2	GO:0008502
GeneOntologyMolecularFunction	ATPase-coupled intramembrane lipid transporter activity	MFSD2A ATP11B ATP8B2	3.04e-04	28	94	3	GO:0140326
GeneOntologyMolecularFunction	macromolecule transmembrane transporter activity	SIDT2 SLC15A4 SIDT1	5.44e-04	34	94	3	GO:0022884
GeneOntologyMolecularFunction	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	PTPMT1 SYNJ1	9.63e-04	10	94	2	GO:0004439
GeneOntologyMolecularFunction	transporter activity	MFSD2A SIDT2 TMEM120B TMEM120A PKD2L2 ATP11B SLC15A4 SLC35C1 SCN2A SIDT1 OTOP2 TRPV4 ATP1A4 SLC7A10 ATP8B2	9.72e-04	1289	94	15	GO:0005215
GeneOntologyMolecularFunction	transmembrane transporter activity	MFSD2A SIDT2 TMEM120B TMEM120A PKD2L2 ATP11B SLC15A4 SLC35C1 SCN2A SIDT1 OTOP2 TRPV4 ATP1A4 SLC7A10	1.21e-03	1180	94	14	GO:0022857
GeneOntologyCellularComponent	Golgi to plasma membrane transport vesicle	RAB3IP RAB3IL1	2.09e-05	2	96	2	GO:0070319
GeneOntologyCellularComponent	nuclear inner membrane	GHRHR TMEM120B TMEM120A ATP11B	1.57e-04	59	96	4	GO:0005637
Domain	SID1_TM_fam	SIDT2 SIDT1	2.56e-05	2	95	2	IPR025958
Domain	Sec2_N	RAB3IP RAB3IL1	2.56e-05	2	95	2	IPR009449
Domain	TMPIT	TMEM120B TMEM120A	2.56e-05	2	95	2	IPR012926
Domain	SID-1_RNA_chan	SIDT2 SIDT1	2.56e-05	2	95	2	PF13965
Domain	Sec2p	RAB3IP RAB3IL1	2.56e-05	2	95	2	PF06428
Domain	TMPIT	TMEM120B TMEM120A	2.56e-05	2	95	2	PF07851
Domain	Melatonin_rcpt	GPR50 MTNR1B	7.65e-05	3	95	2	IPR000025
Domain	G_PROTEIN_RECEP_F2_2	GHRHR ADGRG2 ADGRD2 ADCYAP1R1	1.21e-04	50	95	4	PS00650
Domain	7tm_2	GHRHR ADGRG2 ADGRD2 ADCYAP1R1	1.21e-04	50	95	4	PF00002
Domain	CT	GREM2 VWF MUC5AC	1.83e-04	22	95	3	SM00041
Domain	GPCR_2_secretin-like	GHRHR ADGRG2 ADGRD2 ADCYAP1R1	2.46e-04	60	95	4	IPR000832
Domain	GPCR_2-like	GHRHR ADGRG2 ADGRD2 ADCYAP1R1	2.46e-04	60	95	4	IPR017981
Domain	G_PROTEIN_RECEP_F2_4	GHRHR ADGRG2 ADGRD2 ADCYAP1R1	2.63e-04	61	95	4	PS50261
Domain	Cys_knot_C	GREM2 VWF MUC5AC	2.70e-04	25	95	3	IPR006207
Domain	CTCK_2	GREM2 VWF MUC5AC	2.70e-04	25	95	3	PS01225
Domain	-	ATP11B ATP1A4 ATP8B2	5.68e-04	32	95	3	3.40.1110.10
Domain	-	ATP11B ATP1A4 ATP8B2	5.68e-04	32	95	3	2.70.150.10
Domain	GPCR_2_secretin-like_CS	GHRHR ADGRG2 ADCYAP1R1	6.80e-04	34	95	3	IPR017983
Domain	HAD-like_dom	ATP11B ATP1A4 ATP8B2 CTDSP2	7.05e-04	79	95	4	IPR023214
Domain	ATPase_P-typ_cyto_domN	ATP11B ATP1A4 ATP8B2	7.42e-04	35	95	3	IPR023299
Domain	P_typ_ATPase	ATP11B ATP1A4 ATP8B2	8.06e-04	36	95	3	IPR001757
Domain	ATPase_P-typ_P_site	ATP11B ATP1A4 ATP8B2	8.06e-04	36	95	3	IPR018303
Domain	ATPASE_E1_E2	ATP11B ATP1A4 ATP8B2	8.06e-04	36	95	3	PS00154
Domain	ATPase_P-typ_transduc_dom_A	ATP11B ATP1A4 ATP8B2	8.74e-04	37	95	3	IPR008250
Domain	E1-E2_ATPase	ATP11B ATP1A4 ATP8B2	8.74e-04	37	95	3	PF00122
Domain	G_PROTEIN_RECEP_F2_1	GHRHR ADGRD2 ADCYAP1R1	1.10e-03	40	95	3	PS00649
Domain	GPCR_2_extracellular_dom	GHRHR ADGRD2 ADCYAP1R1	1.10e-03	40	95	3	IPR001879
Domain	G_PROTEIN_RECEP_F2_3	GHRHR ADGRD2 ADCYAP1R1	1.10e-03	40	95	3	PS50227
Domain	TIL	VWF MUC5AC	1.63e-03	12	95	2	PF01826
Domain	C8	VWF MUC5AC	1.63e-03	12	95	2	PF08742
Domain	Unchr_dom_Cys-rich	VWF MUC5AC	1.93e-03	13	95	2	IPR014853
Domain	C8	VWF MUC5AC	1.93e-03	13	95	2	SM00832
Domain	TIL_dom	VWF MUC5AC	2.24e-03	14	95	2	IPR002919
Domain	P_typ_ATPase_c	ATP11B ATP8B2	2.24e-03	14	95	2	IPR032630
Domain	P-type_ATPase_N	ATP11B ATP8B2	2.24e-03	14	95	2	IPR032631
Domain	P-type_ATPase_IV	ATP11B ATP8B2	2.24e-03	14	95	2	IPR006539
Domain	PhoLip_ATPase_C	ATP11B ATP8B2	2.24e-03	14	95	2	PF16212
Domain	PhoLip_ATPase_N	ATP11B ATP8B2	2.24e-03	14	95	2	PF16209
Domain	7TM_GPCR_Srsx	GPR15 GPR50 MTNR1B TAAR5	2.57e-03	112	95	4	SM01381
Domain	VWD	VWF MUC5AC	2.93e-03	16	95	2	SM00216
Domain	VWF_type-D	VWF MUC5AC	2.93e-03	16	95	2	IPR001846
Domain	VWFD	VWF MUC5AC	2.93e-03	16	95	2	PS51233
Domain	VWD	VWF MUC5AC	2.93e-03	16	95	2	PF00094
Domain	CTCK_1	VWF MUC5AC	3.71e-03	18	95	2	PS01185
Domain	VWC_out	VWF MUC5AC	4.14e-03	19	95	2	SM00215
Domain	-	ATP11B ATP8B2 CTDSP2	4.24e-03	64	95	3	3.40.50.1000
Pathway	WP_7Q1123_DISTAL_COPY_NUMBER_VARIATION	TMEM120B TMEM120A PTPMT1	1.62e-04	22	69	3	M48101
Pathway	WP_GPCRS_CLASS_B_SECRETINLIKE	GHRHR ADGRG2 ADCYAP1R1	2.11e-04	24	69	3	M39643
Pathway	WP_GPCRS_CLASS_B_SECRETINLIKE	GHRHR ADGRG2 ADCYAP1R1	2.11e-04	24	69	3	MM15992
Pathway	WP_GPCRS_NONODORANT	GHRHR GPR15 GPR50 ADGRG2 MTNR1B RXFP3 ADCYAP1R1	3.13e-04	266	69	7	MM15843
Pathway	REACTOME_GDP_FUCOSE_BIOSYNTHESIS	SLC35C1 GFUS	3.50e-04	6	69	2	M27611
Pathway	BIOCARTA_BBCELL_PATHWAY	CD28 CD40LG	3.50e-04	6	69	2	MM1552
Pathway	REACTOME_GDP_FUCOSE_BIOSYNTHESIS	SLC35C1 GFUS	3.50e-04	6	69	2	MM15322
Pathway	KEGG_CELL_ADHESION_MOLECULES_CAMS	HLA-DPB1 CD28 CD40LG CD58 OCLN	4.80e-04	133	69	5	M16476
Pubmed	Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases.	ARHGAP5 RASA1	7.54e-06	2	96	2	1689011
Pubmed	The roles of CD28 and CD40 ligand in T cell activation and tolerance.	CD28 CD40LG	7.54e-06	2	96	2	10779746
Pubmed	Shear-induced von Willebrand factor-mediated platelet surface translocation of the CD40 ligand.	VWF CD40LG	7.54e-06	2	96	2	12676191
Pubmed	Mechanism and functional impact of CD40 ligand-induced von Willebrand factor release from endothelial cells.	VWF CD40LG	7.54e-06	2	96	2	25608503
Pubmed	Triggering of murine NK cells by CD40 and CD86 (B7-2).	CD28 CD40LG	7.54e-06	2	96	2	10229827
Pubmed	Role of p120 Ras-GAP in directed cell movement.	ARHGAP5 RASA1	7.54e-06	2	96	2	10769036
Pubmed	The development of a Th1-type response and resistance to Leishmania major infection in the absence of CD40-CD40L costimulation.	CD28 CD40LG	7.54e-06	2	96	2	11698463
Pubmed	Role of CD28 in the generation of effector and memory responses required for resistance to Toxoplasma gondii.	CD28 CD40LG	7.54e-06	2	96	2	10477604
Pubmed	Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis.	CD28 CD40LG	7.54e-06	2	96	2	8617933
Pubmed	Costimulation requirements for antiviral CD8+ T cells differ for acute and persistent phases of polyoma virus infection.	CD28 CD40LG	7.54e-06	2	96	2	16424212
Pubmed	A novel family of mammalian transmembrane proteins involved in cholesterol transport.	SIDT2 SIDT1	7.54e-06	2	96	2	28785058
Pubmed	Role of CD28 co-stimulation in generation and maintenance of virus-specific T cells.	CD28 CD40LG	7.54e-06	2	96	2	12096029
Pubmed	The modulation of CD40 ligand signaling by transmembrane CD28 splice variant in human T cells.	CD28 CD40LG	7.54e-06	2	96	2	15067037
Pubmed	Cloning of a melatonin-related receptor from human pituitary.	GPR50 MTNR1B	7.54e-06	2	96	2	8647286
Pubmed	Systemic RNA Interference Deficiency-1 (SID-1) Extracellular Domain Selectively Binds Long Double-stranded RNA and Is Required for RNA Transport by SID-1.	SIDT2 SIDT1	7.54e-06	2	96	2	26067272
Pubmed	TMEM120A and B: Nuclear Envelope Transmembrane Proteins Important for Adipocyte Differentiation.	TMEM120B TMEM120A	7.54e-06	2	96	2	26024229
Pubmed	Cryo-EM structures of human TMEM120A and TMEM120B.	TMEM120B TMEM120A	7.54e-06	2	96	2	34465718
Pubmed	Aberrant Ras regulation and reduced p190 tyrosine phosphorylation in cells lacking p120-Gap.	ARHGAP5 RASA1	7.54e-06	2	96	2	9121432
Pubmed	HIV gp120 inhibits T cell activation by interfering with expression of costimulatory molecules CD40 ligand and CD80 (B71).	HLA-DPB1 CD28 CD40LG	2.25e-05	20	96	3	7541827
Pubmed	The N-terminal region of GAP regulates cytoskeletal structure and cell adhesion.	ARHGAP5 RASA1	2.26e-05	3	96	2	8344248
Pubmed	Foxp3+ regulatory T cells are activated in spite of B7-CD28 and CD40-CD40L blockade.	CD28 CD40LG	2.26e-05	3	96	2	23348953
Pubmed	Islet allograft rejection in nonobese diabetic mice involves the common gamma-chain and CD28/CD154-dependent and -independent mechanisms.	CD28 CD40LG	2.26e-05	3	96	2	14500690
Pubmed	Requirement for a complex array of costimulators in the negative selection of autoreactive thymocytes in vivo.	CD28 CD40LG	2.26e-05	3	96	2	11342622
Pubmed	Genome-wide association analysis with gray matter volume as a quantitative phenotype in first-episode treatment-naïve patients with schizophrenia.	PIK3C2G HS3ST5	2.26e-05	3	96	2	24086445
Pubmed	Costimulation requirements of induced murine systemic autoimmune disease.	CD28 CD40LG	2.26e-05	3	96	2	15494542
Pubmed	Signaling transduction pathway of angiotensin II in human mesangial cells: mediation of focal adhesion and GTPase activating proteins.	ARHGAP5 RASA1	2.26e-05	3	96	2	10092539
Pubmed	CD40/CD40L interaction is essential for the induction of EAE in the absence of CD28-mediated co-stimulation.	CD28 CD40LG	2.26e-05	3	96	2	11908941
Pubmed	CD28, TNF receptor, and IL-12 are critical for CD4-independent cross-priming of therapeutic antitumor CD8+ T cells.	CD28 CD40LG	2.26e-05	3	96	2	12391201
Pubmed	Evaluation of GPR50, hMel-1B, and ROR-alpha melatonin-related receptors and the etiology of adolescent idiopathic scoliosis.	GPR50 MTNR1B	2.26e-05	3	96	2	20733416
Pubmed	Association of disease-predisposition polymorphisms of the melatonin receptors and sunshine duration in the global human populations.	GPR50 MTNR1B	2.26e-05	3	96	2	20050988
Pubmed	A pull-down procedure for the identification of unknown GEFs for small GTPases.	RAB3IP RAB3IL1	2.26e-05	3	96	2	26918858
Pubmed	Identification of pathway-biased and deleterious melatonin receptor mutants in autism spectrum disorders and in the general population.	GPR50 MTNR1B	2.26e-05	3	96	2	20657642
Pubmed	Soluble CD40 ligand, soluble P-selectin and von Willebrand factor levels in subjects with prediabetes: the impact of metabolic syndrome.	VWF CD40LG	2.26e-05	3	96	2	22100896
Pubmed	Critical role of OX40 in CD28 and CD154-independent rejection.	CD28 CD40LG	2.26e-05	3	96	2	14734751
Pubmed	Role of CD40 ligand and CD28 in induction and maintenance of antiviral CD8+ effector T cell responses.	CD28 CD40LG	4.51e-05	4	96	2	10725727
Pubmed	p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking.	ARHGAP5 RASA1	4.51e-05	4	96	2	8537347
Pubmed	Different costimulatory and growth factor requirements for CD4+ and CD8+ T cell-mediated rejection.	CD28 CD40LG	4.51e-05	4	96	2	15210777
Pubmed	CD58/CD2 Is the Primary Costimulatory Pathway in Human CD28-CD8+ T Cells.	CD28 CD58	4.51e-05	4	96	2	26041540
Pubmed	Changes in melatonin receptor expression in a murine model of glaucoma.	GPR50 MTNR1B	4.51e-05	4	96	2	32818016
Pubmed	Two distinct regions of the CD28 intracytoplasmic domain are involved in the tyrosine phosphorylation of Vav and GTPase activating protein-associated p62 protein.	RASA1 CD28	4.51e-05	4	96	2	9620604
Pubmed	Activated platelets induce Weibel-Palade-body secretion and leukocyte rolling in vivo: role of P-selectin.	VWF CD40LG	4.51e-05	4	96	2	15956287
Pubmed	On costimulatory signals and T cell tolerance: relevance for transplantation immunity.	CD28 CD40LG	4.51e-05	4	96	2	10078224
Pubmed	CD40 ligand functions non-cell autonomously to promote deletion of self-reactive thymocytes.	CD28 CD40LG	4.51e-05	4	96	2	11884443
Pubmed	Costimulation controls diabetes by altering the balance of pathogenic and regulatory T cells.	CD28 CD40LG	4.51e-05	4	96	2	15467837
Pubmed	[A study of costimulatory molecules in allergic allergic rhinitis patients].	CD28 CD40LG	4.51e-05	4	96	2	19086656
Pubmed	RAFTK/Pyk2 tyrosine kinase mediates the association of p190 RhoGAP with RasGAP and is involved in breast cancer cell invasion.	ARHGAP5 RASA1	4.51e-05	4	96	2	10713673
Pubmed	Biology, structure and mechanism of P-type ATPases.	ATP11B ATP1A4 ATP8B2	7.07e-05	29	96	3	15071553
Pubmed	Distinct roles of CD28- and CD40 ligand-mediated costimulation in the development of protective immunity and pathology during Chlamydia muridarum urogenital infection in mice.	CD28 CD40LG	7.50e-05	5	96	2	19398542
Pubmed	Role of CD4 T cell help and costimulation in CD8 T cell responses during Listeria monocytogenes infection.	CD28 CD40LG	7.50e-05	5	96	2	12574376
Pubmed	Mutation screening of melatonin-related genes in patients with autism spectrum disorders.	GPR50 MTNR1B	7.50e-05	5	96	2	20377855
Pubmed	CD40 signaling replaces CD4+ lymphocytes and its blocking prevents chronic rejection of heart transplants.	CD28 CD40LG	7.50e-05	5	96	2	11120867
Pubmed	TACAN Is an Ion Channel Involved in Sensing Mechanical Pain.	TMEM120B TMEM120A	7.50e-05	5	96	2	32084332
Pubmed	CD4+-T-cell effector functions and costimulatory requirements essential for surviving mucosal infection with Citrobacter rodentium.	CD28 CD40LG	7.50e-05	5	96	2	16369024
Pubmed	Immunoregulatory effects of HIV-1 Nef protein.	HLA-DPB1 CD28 CD40LG	9.54e-05	32	96	3	19449444
Pubmed	Functional activity of serotoninergic and melatoninergic systems expressed in the skin.	GPR50 MTNR1B	1.12e-04	6	96	2	12767050
Pubmed	Endothelial lipid phosphate phosphatase-3 deficiency that disrupts the endothelial barrier function is a modifier of cardiovascular development.	VWF PLPP3	1.12e-04	6	96	2	27125875
Pubmed	Ligation of either CD2 or CD28 rescues CD4+ T cells from HIV-gp120-induced apoptosis.	CD28 CD58	1.57e-04	7	96	2	7589092
Pubmed	The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization.	GPR50 MTNR1B	1.57e-04	7	96	2	16778767
Pubmed	Immune evasion and counteraction of restriction factors by HIV-1 and other primate lentiviruses.	CD28 TRIM5	1.57e-04	7	96	2	20638642
Pubmed	Allelic variants of CD40 and CD40L genes interact to promote antibiotic-induced cutaneous allergic reactions.	CD28 CD40LG	1.57e-04	7	96	2	19735272
Pubmed	The type 4 subfamily of P-type ATPases, putative aminophospholipid translocases with a role in human disease.	ATP11B ATP8B2	3.34e-04	10	96	2	15919184
Pubmed	Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells.	CD28 CD40LG	3.34e-04	10	96	2	18328742
Pubmed	Genome wide study of maternal and parent-of-origin effects on the etiology of orofacial clefts.	RASGRF2 SPATA13	4.08e-04	11	96	2	22419666
Pubmed	Timing and casting for actors of thymic negative selection.	CD28 CD40LG	4.08e-04	11	96	2	9973382
Pubmed	TLR4- and TRIF-dependent stimulation of B lymphocytes by peptide liposomes enables T cell-independent isotype switch in mice.	CD28 CD40LG	4.08e-04	11	96	2	23144170
Pubmed	Quantitative trait loci mapping of genes that influence the sensitivity and tolerance to ethanol-induced hypothermia in BXD recombinant inbred mice.	RASA1 SCN2A	4.89e-04	12	96	2	8169823
Pubmed	Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism.	PIK3C2G CD28	4.89e-04	12	96	2	12077252
Pubmed	Differential expression of putative transbilayer amphipath transporters.	ATP11B ATP8B2	5.77e-04	13	96	2	11015572
Pubmed	Mapping of the genes encoding tum- transplantation antigens P91A, P35B, and P198.	RASA1 GFUS	6.71e-04	14	96	2	1348494
Pubmed	MUC1-specific anti-tumor responses: molecular requirements for CD4-mediated responses.	CD28 CD40LG	6.71e-04	14	96	2	12147624
Pubmed	A genome-wide association study identifies two new risk loci for Graves' disease.	HLA-DPB1 CD28	8.82e-04	16	96	2	21841780
Pubmed	Nef proteins from simian immunodeficiency virus-infected chimpanzees interact with p21-activated kinase 2 and modulate cell surface expression of various human receptors.	HLA-DPB1 CD28	9.98e-04	17	96	2	15194762
Pubmed	The activity of Nef on HIV-1 infectivity.	HLA-DPB1 CD28	9.98e-04	17	96	2	24904546
Pubmed	Generalization of variants identified by genome-wide association studies for electrocardiographic traits in African Americans.	DPP6 MFSD2A	1.12e-03	18	96	2	23534349
Pubmed	Combined analysis of three genome-wide association studies on vWF and FVIII plasma levels.	VWF TENT5A	1.12e-03	18	96	2	21810271
Pubmed	Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4.	TAF1B TAF5	1.39e-03	20	96	2	17884155
Pubmed	Systematic interactome mapping of acute lymphoblastic leukemia cancer gene products reveals EXT-1 tumor suppressor as a Notch1 and FBWX7 common interactor.	RINT1 MLH3 DVL3 CTDSP2	1.47e-03	176	96	4	27229929
Pubmed	ESYT1 tethers the ER to mitochondria and is required for mitochondrial lipid and calcium homeostasis.	RINT1 LMF2 EMC1 COPE OCLN	1.47e-03	299	96	5	37931956
Pubmed	Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation.	GPR15 LMF2 TAF1B GTDC1 ANKZF1	1.60e-03	305	96	5	21244100
Pubmed	CUEDC2, a novel interacting partner of the SOCS1 protein, plays important roles in the leukaemogenesis of acute myeloid leukaemia.	GHRHR RASA1 TRIM5	1.83e-03	87	96	3	29991678
Pubmed	Role of HIV-1 Nef protein for virus replication in vitro.	HLA-DPB1 CD28	1.84e-03	23	96	2	19770068
Pubmed	Macrophage signaling in HIV-1 infection.	CD28 CD40LG	1.84e-03	23	96	2	20380698
Pubmed	Non-EST-based prediction of novel alternatively spliced cassette exons with cell signaling function in Caenorhabditis elegans and human.	CD58 GTDC1	2.00e-03	24	96	2	17452356
Pubmed	Editorial. Nef: a notorious enigmatic factor in HIV biology.	HLA-DPB1 CD28	2.00e-03	24	96	2	22175768
Pubmed	Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.	CD28 CD58	2.17e-03	25	96	2	19898481
Pubmed	HIV accessory proteins and surviving the host cell.	HLA-DPB1 CD28	2.17e-03	25	96	2	16091223
Pubmed	Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.	DPP6 DNASE2B USH2A TRIM5	2.29e-03	199	96	4	23382691
Pubmed	An introduction to TRP channels.	PKD2L2 TRPV4	2.53e-03	27	96	2	16460286
Pubmed	[The HIV nef and the Kaposi-sarcoma-associated virus K3/K5 proteins: "parasites"of the endocytosis pathway].	HLA-DPB1 CD28	2.53e-03	27	96	2	12836198
Pubmed	Global genetic analysis in mice unveils central role for cilia in congenital heart disease.	SC5D DVL3 CPLANE1	2.72e-03	100	96	3	25807483
Pubmed	One protein to rule them all: modulation of cell surface receptors and molecules by HIV Nef.	HLA-DPB1 CD28	2.72e-03	28	96	2	22103833
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WDR93 CATIP GOT1L1 CFAP54 PIK3C2G AK8	2.35e-06	177	96	6	e8bb4f8ecd5e283efec966b9fc2040a6152d5551
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-ependymal_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WDR93 CATIP GOT1L1 CFAP54 PIK3C2G AK8	2.43e-06	178	96	6	b1db59344c074c7c80169fc2c5cd5fc89f3fe463
ToppCell	facs-Brain_Non-Myeloid-Striatum-24m-Mesenchymal-Ependyma\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WDR93 CATIP GOT1L1 CFAP54 PIK3C2G AK8	2.43e-06	178	96	6	579cdc14f28b459e200ae2102e0bd4df8a2c0dcb
ToppCell	T_cells-Central_memory_CD4+_T_cells\|T_cells / Immune cells in Kidney/Urine in Lupus Nephritis	ARHGAP5 RASGRF2 CD28 CD40LG VSIG1 ATP8B2	3.65e-06	191	96	6	25dd538d6a361bd3367c8a1c0dfc9e7003061af3
ToppCell	Children_(3_yrs)-Immune-T_lymphocyte-D139\|Children_(3_yrs) / Lineage, Cell type, age group and donor	RASGRF2 CD28 CD40LG SIDT1 IFI16 ATP8B2	3.99e-06	194	96	6	3d6f2d190dd50804afea299957cc44c2bb756134
ToppCell	Fetal_29-31_weeks-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D088\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	PIGL TENT5A OTOP2 HS3ST5 OCLN	1.73e-05	148	96	5	9fe3c0a5904b8e9a0f28130f8d84d4f2a819b06c
ToppCell	facs-Lung-ENDOMUCIN-18m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD28 RAB3IP CD40LG SIDT1 SOAT2	2.75e-05	163	96	5	4af92b211d12c5b88b65bb746242cd702b545bd0
ToppCell	facs-Lung-ENDOMUCIN-18m-Lymphocytic-CD4+_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD28 RAB3IP CD40LG SIDT1 SOAT2	2.75e-05	163	96	5	d24774e0aa612322c22fdb3b314aef275fa01d68
ToppCell	facs-Liver-Liver_non-hepato/SCs-18m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	KY GPR15 CD28 CD40LG SIDT1	3.55e-05	172	96	5	33c201aaa98acbf1901b6fa6ce0d3ff8012a4d94
ToppCell	TCGA-Breast-Solid_Tissue_Normal-Breast_normal_tissue-Breast_normal_tissue-3\|TCGA-Breast / Sample_Type by Project: Shred V9	KY BMX MAMDC2 SLC7A10 ADCYAP1R1	3.76e-05	174	96	5	7f8f5fafae08676d2b90cab9802c3c9320f1370e
ToppCell	TCGA-Breast-Solid_Tissue_Normal\|TCGA-Breast / Sample_Type by Project: Shred V9	KY BMX MAMDC2 SLC7A10 ADCYAP1R1	3.76e-05	174	96	5	e2f240d60bffbe8e6d60f0bb405b231bd3c96875
ToppCell	TCGA-Breast-Solid_Tissue_Normal-Breast_normal_tissue-Breast_normal_tissue\|TCGA-Breast / Sample_Type by Project: Shred V9	KY BMX MAMDC2 SLC7A10 ADCYAP1R1	3.76e-05	174	96	5	0f3ec0d0d4344e10c9b48adc9174123f6402dc51
ToppCell	TCGA-Breast-Solid_Tissue_Normal-Breast_normal_tissue\|TCGA-Breast / Sample_Type by Project: Shred V9	KY BMX MAMDC2 SLC7A10 ADCYAP1R1	3.76e-05	174	96	5	1aadbf2642b6d1320ceabd92e6ff59e11f16c315
ToppCell	facs-Lung-nan-3m-Lymphocytic-CD4-positive,_alpha-beta_T_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP11B CD28 RAB3IP CD40LG SIDT1	4.19e-05	178	96	5	a9a8567d8fdc0fffd612fee16b5b29ef7b1c9307
ToppCell	facs-BAT-Fat-3m-Lymphocytic-T_cell\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP11B CD28 RAB3IP CD40LG SIDT1	4.19e-05	178	96	5	7c101e3957ea9b0d4ebf619d1d02e7e64ae28915
ToppCell	facs-Lung-nan-3m-Lymphocytic-CD4+_T\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ATP11B CD28 RAB3IP CD40LG SIDT1	4.19e-05	178	96	5	5ecbea15efd304057aef826ec2f385997bfaf0c9
ToppCell	droplet-Lung-LUNG-30m-Endothelial-Artery_endothelial_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WDR93 BMX VWF RASGRF2 OCLN	4.30e-05	179	96	5	a09647750eba9d93c5efc1db3b555fefb5eec7b5
ToppCell	droplet-Kidney-nan-21m-Epithelial-Pecam____Kidney_cortex_artery_cell\|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	BMX VWF RASGRF2 MAMDC2 HS3ST5	4.30e-05	179	96	5	b7281160c84dd053a2981c9c76ea6cc6d2592cd5
ToppCell	facs-Spleen-nan-18m-Lymphocytic-CD8-positive,_alpha-beta_T_cell\|Spleen / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR15 CD28 RAB3IP SIDT1 SPATA13	4.41e-05	180	96	5	407fd8f61a757626e082b6e2eefd3a33276e6b71
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Mesenchymal-ependymal_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WDR93 KY CATIP GOT1L1 AK8	4.77e-05	183	96	5	6ca7c2d7c56e0f1b9038ba677b4c1c3dfd63bfce
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Mesenchymal-Ependyma\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WDR93 KY CATIP GOT1L1 AK8	4.77e-05	183	96	5	18040d0653286071df959513c63d94b555a5d00a
ToppCell	367C-Endothelial_cells-Endothelial-B_(Artery)-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	BMX TMEM120A SIDT1 CD58 SPATA13	5.03e-05	185	96	5	b57dae20c21f984edd2acee4344d86f033108ebf
ToppCell	367C-Endothelial_cells-Endothelial-B_(Artery)\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	BMX TMEM120A SIDT1 CD58 SPATA13	5.03e-05	185	96	5	d3b054d203e575c1bb5455aa7a2e551a0957a760
ToppCell	15-Distal-Immune-Hematopoietic,_T_Cells\|Distal / Age, Tissue, Lineage and Cell class	CD28 CD40LG SIDT1 VSIG1 SOAT2	5.03e-05	185	96	5	481e3d3b63f2e5b4783088523c3cf70a461aed27
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-BM_CD8_+_CD4_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR15 CD28 CD40LG SIDT1 SPATA13	5.16e-05	186	96	5	4dce1484653bb266e2305cbb306fb11eaf7892e2
ToppCell	facs-Marrow-T-cells-3m-Lymphocytic-mature_alpha-beta_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR15 CD28 CD40LG SIDT1 SPATA13	5.16e-05	186	96	5	e23e1246914e230369a716d0d666b98383bf8512
ToppCell	COVID-19-Heart-EC_2\|Heart / Disease (COVID-19 only), tissue and cell type	BMX CFAP54 VWF RASGRF2 SIDT1	5.29e-05	187	96	5	40ffc06a3e3251d9b12da390210d3e045af7537a
ToppCell	Smart-seq2-lymph_node_(Smart-seq2)-lymphocytic-T_lymphocytic-effector_CD4-positive,_alpha-beta_T_cell\|lymph_node_(Smart-seq2) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	RASGRF2 SC5D CD28 CD40LG ATP8B2	5.29e-05	187	96	5	e61c1755531469dd3850c9740474b5ad4e0499c1
ToppCell	severe_influenza-CD4+_Tcm\|severe_influenza / disease group, cell group and cell class (v2)	GREM2 SC5D CD28 CD40LG ATP8B2	5.43e-05	188	96	5	633e5545f49b1b864b0ffa5fc9688d270690f884
ToppCell	Adult-Immune-T_lymphocyte-D175\|Adult / Lineage, Cell type, age group and donor	RASGRF2 CD28 CD40LG SIDT1 ATP8B2	5.85e-05	191	96	5	0b84fd1dc68146d9f72422b102744d2847f5ecb2
ToppCell	Control-Stromal_mesenchymal\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GREM2 NWD2 PLPP3 MAMDC2 ABLIM3	5.85e-05	191	96	5	14057205ddb9b4bbc582d1358d13cf36d979a61b
ToppCell	mild_COVID-19_(asymptomatic)-CD4+_Tcm\|mild_COVID-19_(asymptomatic) / disease group, cell group and cell class (v2)	GREM2 RASGRF2 CD28 CD40LG VSIG1	6.14e-05	193	96	5	498d3a83bce6deff69aea71b18a43688e0a8ed7d
ToppCell	T_cells-Central_memory_CD4+_T_cells\|World / Immune cells in Kidney/Urine in Lupus Nephritis	RASGRF2 CD28 CD40LG VSIG1 ATP8B2	6.14e-05	193	96	5	725326d7e3604736b607c19f4069c81cb4f2d20c
ToppCell	Adult-Immune-T_lymphocyte\|Adult / Lineage, Cell type, age group and donor	RASGRF2 CD28 CD40LG SIDT1 ATP8B2	6.14e-05	193	96	5	26df0c4c8a2355dd5503fadd07e368eb9a2bf06a
ToppCell	Adult-Immune-T_lymphocyte-D231\|Adult / Lineage, Cell type, age group and donor	RASGRF2 CD28 CD40LG SIDT1 ATP8B2	6.30e-05	194	96	5	5c1dca33f382f37a7deb23e573578343c3b54986
ToppCell	Control_saline-Epithelial_airway-airway_epithelial-Ciliated\|Control_saline / Treatment groups by lineage, cell group, cell type	CATIP CFAP54 TRPV4 AK8 SOAT2	6.45e-05	195	96	5	60067b5359174f0d1a8b5748bfc0690762e9e740
ToppCell	droplet-Bladder-nan-24m-Endothelial\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF ADAMTS4 RASGRF2 MAMDC2 ABLIM3	6.61e-05	196	96	5	9a90dd26e7a43e3fd55e7c5d8354cfa4cdd5a6cc
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-T_lymphocytic-naive_thymus-derived_CD4-positive,_alpha-beta_T_cell\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	SC5D CD28 CD40LG VSIG1 ATP8B2	6.61e-05	196	96	5	b999759051499b725d02d919a89234a4467df35c
ToppCell	10x_3'_v3-spleen_(10x_3'_v3)-lymphocytic-T_lymphocytic-CD4-positive,_alpha-beta_memory_T_cell\|spleen_(10x_3'_v3) / Per Platform+tissue_group, by lineage_subgroup, cell_group, cell_type	RASGRF2 SC5D CD28 CD40LG ATP8B2	6.61e-05	196	96	5	b10810c6a2ad3d3b968bfef46a68a38e0ce31331
ToppCell	droplet-Bladder-nan-24m-Endothelial-endothelial_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF ADAMTS4 RASGRF2 MAMDC2 ABLIM3	6.61e-05	196	96	5	04dfef1bd4ebb0e9469ae80024dc177e469a2560
ToppCell	healthy_donor-Lymphocytic-T_cell\|healthy_donor / Disease condition, Lineage, Cell class and subclass	RASGRF2 CD28 CD40LG VSIG1 ATP8B2	6.77e-05	197	96	5	63d0f06e150e7eb800ecb70e97b9d12a01c84e37
ToppCell	droplet-Bladder-nan-24m-Endothelial-endothelial_cell\|Bladder / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	VWF ADAMTS4 RASGRF2 MAMDC2 ABLIM3	6.77e-05	197	96	5	488e85991c5e668afb7672942726d9295b8fc7d8
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD4\|bone_marrow / Manually curated celltypes from each tissue	GREM2 SC5D CD28 CD40LG VSIG1	6.93e-05	198	96	5	f2d85d7ca0e867d20ad4d2b1cbbfd91a066c1a03
ToppCell	Tracheal-NucSeq-Endothelial-Endothelia_vascular-VE_pulmonary_arterial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	BMX TMEM120A VWF RASGRF2 ABLIM3	6.93e-05	198	96	5	f88198e11e835ad53d339c312f8f7b7b0b5c02d3
ToppCell	Influenza-Influenza_Severe-Lymphocyte-T/NK-CD4+_Tcm\|Influenza_Severe / Disease, condition lineage and cell class	GREM2 SC5D CD28 CD40LG ATP8B2	6.93e-05	198	96	5	fc99f2e300d76126d05c0c43e11cdbbeb74f6f0d
ToppCell	10x5'-bone_marrow-Lymphocytic_T_CD4-Teffector/EM_CD4\|bone_marrow / Manually curated celltypes from each tissue	GREM2 GPR15 CD28 CD40LG VSIG1	7.10e-05	199	96	5	e0c01ce4301f8446d990180ec336593ef0148b38
ToppCell	Transverse-T_cell-Tcm\|Transverse / Region, Cell class and subclass	WDR93 PRICKLE4 SC5D CD28 VSIG1	7.10e-05	199	96	5	b98964bdc707761dad94823510036e0af0ed1242
ToppCell	Transverse-(1)_T_cell-(14)_Tcm\|Transverse / shred on region, Cell_type, and subtype	WDR93 PRICKLE4 SC5D CD28 VSIG1	7.10e-05	199	96	5	c885c53cc8d1382acc176c8029430d218ac41cc5
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_ciliated-Ciliated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	WDR93 CATIP CFAP54 TRPV4 AK8	7.27e-05	200	96	5	926a7ea94b5908aebf103893ea83ce9d25285b65
ToppCell	Tracheal-10x5prime-Endothelial\|10x5prime / Cell types per location group and 10X technology with lineage, and cell group designations	BMX VWF ADAMTS4 HLA-DPB1 ABLIM3	7.27e-05	200	96	5	71ba0e48ca4ded077f2b96a0cf4f2331f2e25d15
ToppCell	Influenza-Influenza_Severe-Lymphocyte-T/NK-CD4+_T_naive\|Influenza_Severe / Disease, condition lineage and cell class	GREM2 SC5D CD28 CD40LG VSIG1	7.27e-05	200	96	5	0382f8fc27d18003761725e714beb6b3f3150057
ToppCell	Parenchymal-NucSeq-Epithelial-Epi_airway_ciliated\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	WDR93 CATIP CFAP54 TRPV4 AK8	7.27e-05	200	96	5	06ce6e03498ba38ef6a06eaf2731e3b2eeda59eb
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-T/NK-CD4+_T_activated\|COVID-19_Severe / Disease, condition lineage and cell class	RASGRF2 CD28 CD40LG VSIG1 ATP8B2	7.27e-05	200	96	5	deeed668b129e66156b5f6abe1a07a9bf842a14d
ToppCell	LPS-antiTNF-Lymphocytic_NKT-T_cells-Erythroid\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	PKD2L2 CD28 SOAT2 AAR2	1.60e-04	126	96	4	54247ce9ee0a4f123f1fb225600a4ec698510a86
ToppCell	TCGA-Prostate-Solid_Tissue_Normal-Prostate_normal_tissue-Prostate_normal_tissue-3\|TCGA-Prostate / Sample_Type by Project: Shred V9	MFSD2A PIK3C2G HS3ST5 ADGRD2	1.96e-04	133	96	4	3e0e37dfb07a2de72e2b49f32ff201c3ec56f247
ToppCell	PND01-03-samps-Mesenchymal-Matrix_fibroblast-FB-3\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	MAMDC2 ABLIM3 MUC5AC SLC7A10	2.20e-04	137	96	4	25b5370b63644351efddb8749ef174beca0581cd
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Cbln1-Excitatory_Neuron.Slc17a7.Cbln1-Gpr88_(Medial_entorrhinal_cortex)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	DNASE2B OTOP2 USH2A	2.40e-04	56	96	3	a310f50724ada8da92257c54b18d9214d7415010
ToppCell	Hippocampus-Neuronal-Excitatory-eN3(Slc17a7_Gad1Gad2)-Cbln1-Excitatory_Neuron.Slc17a7.Cbln1-Gpr88_(Medial_entorrhinal_cortex)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	DNASE2B OTOP2 USH2A	2.40e-04	56	96	3	4740900fffc892200f3e2480328eb43cb6d19f20
ToppCell	LPS-antiTNF-Endothelial-Epi-like\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	WDR93 DPP6 SCN2A TAF1B	2.66e-04	144	96	4	75b16adfbe84f69376e6566d531ba7919d5c5192
ToppCell	Parenchymal-10x3prime_v2-Stromal-Peri/Epineurial_-NAF_endoneurial\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	SLC15A4 MAMDC2 FAM227B TMEM104	2.73e-04	145	96	4	e808502fa52baf1c400f3c9b918a167127e78af9
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Outer_Medullary_Collecting_Duct_Principal_Cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	KY PIK3C2G SCN2A HS3ST5	2.73e-04	145	96	4	bfa196ac1db7acbfcbb2ba9f137036a95e16e091
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2.Synpr-Pcdh11x_(Neuron.Gad1Gad2.Synpr-Pcdh11x)\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	GPR50 FAM227B MUC5AC	2.81e-04	59	96	3	439a9d56eeecccd70a4defb430e228329655cb80
ToppCell	Frontal_cortex-Neuronal-Inhibitory-iN2(Gad1Gad2)-Synpr-Inhibitory_Neuron.Gad1Gad2.Synpr-Pcdh11x_(Neuron.Gad1Gad2.Synpr-Pcdh11x)-\|Frontal_cortex / BrainAtlas - Mouse McCarroll V32	GPR50 FAM227B MUC5AC	2.81e-04	59	96	3	50432c7b52fd197e8856ba0296c34cf66a2faaf5
ToppCell	368C-Fibroblasts-Fibroblast-F\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	PKD2L2 MTBP OCLN ATP8B2	3.03e-04	149	96	4	f53151d9e5e724a61be0ee6a8c740d1990f28d5f
ToppCell	368C-Fibroblasts-Fibroblast-F-\|Fibroblasts / Donor, Lineage, Cell class and subclass (all cells)	PKD2L2 MTBP OCLN ATP8B2	3.03e-04	149	96	4	9286bc56ff2e245630537a0bda5f1a1e17be863a
ToppCell	LPS-antiTNF-Endothelial-Epi-like-Gen_Cap\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	WDR93 SCN2A TAF1B HS3ST5	3.11e-04	150	96	4	9cb3332924bd67c966873343c14445e30d3f384f
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Mucinous_Lepidic_Adenocarcinoma-7\|TCGA-Lung / Sample_Type by Project: Shred V9	GHRHR KY PIK3C2G MUC5AC	3.19e-04	151	96	4	3dfa1d89975ffaa45b26833538244153d50c60a7
ToppCell	TCGA-Lung-Primary_Tumor-Lung_Carcinoma-Lung_Mucinous_Lepidic_Adenocarcinoma\|TCGA-Lung / Sample_Type by Project: Shred V9	GHRHR KY PIK3C2G MUC5AC	3.19e-04	151	96	4	60bb6de5d9b13402bc18cb6d5e51078326dff8e2
ToppCell	Epithelial-Epithelial-B_(AT1-AT2-progenitors)\|Epithelial / shred on cell class and cell subclass (v4)	LMF2 RASA1 OTOP2 RNASEK	3.43e-04	154	96	4	770712806e26f73456fb77a81aa4ef8ec78a21ea
ToppCell	Club-club-7\|World / Class top	PRICKLE4 GOT1L1 ADCYAP1R1	3.57e-04	64	96	3	df413c5328966480479c41826461c4d817fbe33d
ToppCell	LPS-antiTNF-Epithelial_alveolar-AT_1-AT1\|LPS-antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DPP6 ITLN1 SCN2A HS3ST5	3.69e-04	157	96	4	9665a1375cfd8e9b8781c852686591226c0e0d9a
ToppCell	Control-Epithelial_alveolar-AT_2-Differentiating_AT1\|Control / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	DPP6 SIDT2 TENT5A OCLN	3.69e-04	157	96	4	4766f7d545bf2d775390589460677519cb92f4d5
ToppCell	Influenza_Severe-CD4+_T_naive\|Influenza_Severe / Disease group and Cell class	GREM2 SC5D CD40LG VSIG1	3.69e-04	157	96	4	287bdc4e455cd0160261a93d13538e0def49fcd4
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_B-Plasma_Cell-\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CFAP54 COPE VSIG1 ATP8B2	3.78e-04	158	96	4	6b51e5ee08e23924f5edbaf0a845a9232fb7ff7a
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Immune-Lymphocytic_B-Plasma_Cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	CFAP54 COPE VSIG1 ATP8B2	3.78e-04	158	96	4	8dd83a2a4c2ec9cdc3a03df8b51ee22bee1c2888
ToppCell	PND03-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_T-CD4_T-CD4_T_prolif\|PND03 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif	GOT1L1 CD28 CD40LG SIDT1	3.87e-04	159	96	4	a5509f0604ef0caef5ed1af83dd89c86686c73cc
ToppCell	facs-Lung-3m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GPR15 CD28 CD40LG SIDT1	3.87e-04	159	96	4	4750ba9ca06ed97b18df3c74eeb51d3ac8763f63
ToppCell	Anterior_Cingulate_gyrus_(CgG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_3-Exc_L3_RORB_CARTPT\|Anterior_Cingulate_gyrus_(CgG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	MFSD2A PIK3C2G MTNR1B MUC5AC	3.87e-04	159	96	4	285777c38891efe467c55a641ce089e28903e970
ToppCell	368C-Myeloid-Macrophage-FABP4+_Macrophage_2\|368C / Donor, Lineage, Cell class and subclass (all cells)	CATIP DNASE2B PTPMT1 HLA-DPB1	3.97e-04	160	96	4	ac3f56f8ab8efd11c4b4868a828db05c23ac762f
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Mesenchymal-Fibroblast-kidney_interstitial_fibroblast\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	NWD2 ADGRG2 TENT5A SLC7A10	4.06e-04	161	96	4	a006491c991e6a134be20ad75092a91f3b7c3c91
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_1-AT1\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	GREM2 DPP6 ITLN1 HS3ST5	4.06e-04	161	96	4	1e17a993126e1f2a25ee7dfbb95a74ccb2a26791
ToppCell	facs-Marrow-T-cells-24m-Lymphocytic-mature_alpha-beta_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFAP54 CD28 CD40LG SPATA13	4.16e-04	162	96	4	b5b2cdbcc5bbfab52cc7d8a5504d34bb2e73771a
ToppCell	10x5'-blood-Lymphocytic_T_CD4-T_CD4/CD8\|blood / Manually curated celltypes from each tissue	RASA1 SC5D CD28 ATP8B2	4.16e-04	162	96	4	b4535bcb3f469bc139e73f1122f4070013e5a1de
ToppCell	severe_influenza-CD4+_Tcm\|World / disease group, cell group and cell class (v2)	GREM2 SC5D CD40LG ATP8B2	4.16e-04	162	96	4	7137990e6e1473665911e39a22092a05ae25ce74
ToppCell	facs-Marrow-T-cells-24m-Lymphocytic-BM_CD8_+_CD4_T_cell\|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CFAP54 CD28 CD40LG SPATA13	4.16e-04	162	96	4	4f9cf67b4b00b1cf78eeb9be1c701d535021a61d
ToppCell	368C-Myeloid-Macrophage-M2-like_Macrophage_(MARCO_negative)\|Myeloid / Donor, Lineage, Cell class and subclass (all cells)	HLA-DPB1 MAMDC2 IFI16 RAB3IL1	4.26e-04	163	96	4	4b8abbad4df040c895e3afb240759ebbc66b4d0e
ToppCell	facs-BAT-Fat-3m-Lymphocytic-NK_cell\|BAT / Fat_BAT_GAT_MAT_SCAT - method, tissue, subtissue, age, lineage, cell ontology and free annotation	CD28 SIDT1 USP48 SPATA13	4.36e-04	164	96	4	cbdb7e893cb3959b9920c0c7c535ace03a5f4986
ToppCell	PBMC-Severe-cDC_2\|Severe / Compartment, Disease Groups and Clusters	WDR93 RASGRF2 CD40LG	4.45e-04	69	96	3	0fab02d29408415d3aa1f42a55a2e37b458c4030
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Lymphocytic-nan\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR15 CD28 CD40LG SIDT1	4.56e-04	166	96	4	d80c2522cf314d56730d60f160b1247933443378
ToppCell	facs-Brain_Non-Myeloid-Hippocampus-3m-Lymphocytic\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR15 CD28 CD40LG SIDT1	4.56e-04	166	96	4	f2593e2f1043a8cedaa677a73e6b28393991b910
ToppCell	facs-Lung-3m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l9\|3m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	GPR15 CD28 CD40LG SIDT1	4.66e-04	167	96	4	38b1f052d663fa8f407c54bdd2060216f26feb0e
ToppCell	356C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|356C / Donor, Lineage, Cell class and subclass (all cells)	SC5D CD28 CD40LG SOAT2	4.77e-04	168	96	4	9d6ca10c272aea28082c09d469940f7232f6461c
ToppCell	TCGA-Colorectal-Solid_Tissue_Normal-Rectum_normal_tissue-Rectum_normal_tissue-6\|TCGA-Colorectal / Sample_Type by Project: Shred V9	GREM2 DPP6 MAMDC2 OTOP2	4.77e-04	168	96	4	5ce3129a023a48a3d7e6b9306c1fc5addfef9675
ToppCell	3'-Adult-LargeIntestine-Epithelial-goblet-Goblet_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	DPP6 ITLN1 GFUS ZNF709	4.77e-04	168	96	4	2163e6774eb7a3d010422e4d59be5e45b4158329
ToppCell	facs-Lung-18m-Hematologic-lymphocytic-CD8-positive,_alpha-beta_T_cell-CD8-positive,_alpha-beta_T_cell_l21\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	MFSD2A CD28 CD40LG SIDT1	4.77e-04	168	96	4	6c758eb120faf06ff72d157b495e399191c79ec9
ToppCell	Adult-Endothelial-endothelial_cell_of_artery-D122\|Adult / Lineage, Cell type, age group and donor	BMX VWF RASGRF2 ITLN1	4.77e-04	168	96	4	8c3e1e45b422813bcdfa4273b1167db649a312f5
ToppCell	facs-Lung-18m-Hematologic-lymphocytic-CD4-positive,_alpha-beta_T_cell\|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	CD28 RAB3IP CD40LG SIDT1	4.77e-04	168	96	4	68ee3b3b012b56584e313813feb16e632e3f72d2
ToppCell	TCGA-Colorectal-Solid_Tissue_Normal-Rectum_normal_tissue\|TCGA-Colorectal / Sample_Type by Project: Shred V9	DPP6 MAMDC2 OTOP2 ADCYAP1R1	4.88e-04	169	96	4	41cb92b0558f0d5a3e511058efd9110258b88ee3
ToppCell	TCGA-Colorectal-Solid_Tissue_Normal-Rectum_normal_tissue-Rectum_normal_tissue\|TCGA-Colorectal / Sample_Type by Project: Shred V9	DPP6 MAMDC2 OTOP2 ADCYAP1R1	4.88e-04	169	96	4	91f4b6a14708e701b2af22989004282041777491
ToppCell	facs-Heart-LV-18m-Lymphocytic-T_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DOCK5 CD28 CD40LG SIDT1	4.99e-04	170	96	4	71e5e27c3c4e6cc8dc9b063bd51c21c049f54416
Disease	schizophrenia, grey matter volume measurement	PIK3C2G HS3ST5	9.98e-05	5	94	2	EFO_0005420, MONDO_0005090
Disease	Autism Spectrum Disorders	DPP6 GPR50 MTNR1B USH2A	1.61e-04	85	94	4	C1510586
Disease	Peripheral T-Cell Lymphoma	CD28 CD58	4.44e-04	10	94	2	C0079774
Disease	Berylliosis	HLA-DPB1 CD28	5.42e-04	11	94	2	C0005138
Disease	level of Sterol ester (27:1/20:5) in blood serum	NWD2 RAB3IL1	5.42e-04	11	94	2	OBA_2045197
Disease	Beryllium Disease	HLA-DPB1 CD28	5.42e-04	11	94	2	C2350873
Disease	diabetic angiopathy (is_marker_for)	CD28 CD40LG	6.49e-04	12	94	2	DOID:11713 (is_marker_for)
Disease	SLAM family member 7 measurement	ADAMTS4 ITLN1	1.32e-03	17	94	2	EFO_0008287
Disease	lysophosphatidylcholine 20:5 measurement	DNASE2B RAB3IL1	1.66e-03	19	94	2	EFO_0010364
Disease	carotid artery disease (is_marker_for)	VWF CD40LG	1.66e-03	19	94	2	DOID:3407 (is_marker_for)
Disease	obsolete Mendelian syndromes with cleft lip/palate	RASGRF2 SPATA13	2.43e-03	23	94	2	MONDO_0015335
Disease	Sjogren's syndrome (is_marker_for)	CD40LG MUC5AC	2.65e-03	24	94	2	DOID:12894 (is_marker_for)
Disease	Lynch syndrome (is_implicated_in)	MLH3 TAF1B	2.65e-03	24	94	2	DOID:3883 (is_implicated_in)

Protein segments in the cluster

Peptide	Gene	Start	Entry
AFFQIYPDCLAQAIY	FAM227B	246	Q96M60
FFFKNQEYICTQDYQ	ABLIM3	61	O94929
QEYICTQDYQQLYGT	ABLIM3	66	O94929
DNYQVLFQTSCTFLY	CFAP54	2761	Q96N23
CVVYGNYSQQLQVYS	CD28	66	P10747
QGLYYIYAQVTFCSN	CD40LG	166	P29965
TLINYVSFINYLCYG	SLC7A10	386	Q9NS82
LQYFVSQGFEFFCSQ	GOT1L1	231	Q8NHS2
YIVTEYISNGCLLNY	BMX	486	P51813
AFANSCVNPFIYYIF	GPR15	291	P49685
QFAFVCFLLGNVYEA	AAR2	256	Q9Y312
NNNAVFYITVVGYFC	ADGRG2	781	Q8IZP9
YLFQGRQECYAFNGT	HLA-DPB1	36	P04440
DVKNAFYIGSYQQCI	COPE	21	O14579
FYIGSYQQCINEAQR	COPE	26	O14579
VNKITFSEQCYYIFG	DVL3	481	Q92997
FCGFSAQTVYDQYFI	ATP8B2	911	P98198
LYAFCGQYLNTTTIF	NWD2	1111	Q9ULI1
AVCNFFTYIRYIQQG	RAB3IL1	336	Q8TBN0
FTNPYCNIYLNSVQV	RASA1	611	P20936
CNFFTYIRYIQQGLV	RAB3IP	431	Q96QF0
SLYGSQIYALCNQFY	OCLN	206	Q16625
VYCNSFYADFQPVNV	PIK3C2G	496	O75747
CLSFYYQIQQGNDNV	MAMDC2	246	Q7Z304
YFLRTENGVIYQTFC	ITLN1	56	Q8WWA0
ISCFSQQIYGVVYGN	CD58	26	P19256
GNYIFVFNYLVCCAN	KY	546	Q8NBH2
LAYFNSCLNAIVYGL	MTNR1B	296	P49286
YTCIFNYLNNPVFTV	GPR50	176	Q13585
FIAYFNSCLNAVIYG	GPR50	281	Q13585
QYNLYFNATRGFYCL	HS3ST5	281	Q8IZT8
CVDVFYQALTYVQSN	AK8	246	Q96MA6
ELYGIYVINVQCQFC	MLH3	301	Q9UHC1
DVQNRAYFQQYGCTF	GFUS	151	Q13630
YYTFLDNCTYVLVQQ	MUC5AC	4936	P98088
TILNRFCYGQCNSFY	GREM2	91	Q9H772
FQGFVVAVLYCFLNG	ADCYAP1R1	391	P41586
AVCQIFQQGYFYLYP	OTOP2	231	Q7RTS6
YQVTGCALGFFLQIY	MFSD2A	56	Q8NA29
CQACGQALINLIYFY	PRICKLE4	116	Q2TBC4
QFALKYQSLGQCVYV	PTPMT1	116	Q8WUK0
NNLCLKYVGVAFYNV	SLC35C1	131	Q96A29
LTCQAQALGYYYVLE	ADAMTS4	621	O75173
IYQAFQGLVLYYESC	DNASE2B	346	Q8WZ79
TYGLYVNFKNFVCNI	DOCK5	221	Q9H7D0
NYIVVCITHFFYILQ	CPLANE1	596	Q9H799
LFQNAQGQFLYAYRC	ANKZF1	166	Q9H8Y5
QCLQYQFYQIPGTCL	CTDSP2	76	O14595
CYLTYQNLGFQTIQV	CATIP	206	Q7Z7H3
SFQGFIVAILYCFLN	GHRHR	366	Q02643
AIANYVCRNGFLEVY	IFI16	631	Q16666
QYCGTGQFLVYNFIN	ESCO1	821	Q5FWF5
LACFNQTYTINLYLV	EMC1	366	Q8N766
GQQLIFIFENNIYYC	DPP6	251	P42658
FQYGYNQILSCLVAD	GTDC1	106	Q4AE62
NINGCYLNYYFFLLA	SLC15A4	526	Q8N697
FAVQAIYGFYQFCSS	MTBP	81	Q96DY7
LIFLFYYPQNNISSC	MOXD2P	466	A6NHM9
AVPFSQEYFLCQVYA	RXFP3	356	Q9NSD7
QEYFLCQVYAFPVSV	RXFP3	361	Q9NSD7
ICFYTFLNAYQGLTA	TAF5	461	Q15542
FNSACNPIIYVFSYQ	TAAR5	296	O14804
ENGQYQVFYIIIQFF	USH2A	376	O75445
NVTGNQDICYYNFLC	SIDT2	476	Q8NBJ9
LSYVCNTQAEYQQGF	TBC1D21	151	Q8IYX1
AFSIFQSCVQFLQYY	TMEM120B	221	A0PK00
QSCVQFLQYYYQRGC	TMEM120B	226	A0PK00
YGFFYFNGSEVQRCQ	SYNJ1	361	O43426
SFVQFLQYYYQSGCL	TMEM120A	231	Q9BXJ8
YLSACQVGQVFLYFQ	LMF2	111	Q9BU23
VYLLCFSAGNYYNQG	PIGL	71	Q9Y2B2
FSQINCSEGYIQNYR	PLPP3	166	O14495
LYQNVLFYFEGEQSC	RASGRF2	46	O14827
VCEGFQYILYQQAEA	TAF1B	76	Q53T94
FIQQCQFFFYNGEIV	ARHGAP5	1441	Q13017
CNDYFFNYFTLGVDI	PHAF1	281	Q9BSU1
YVAKNFAQALGCVLY	SOAT2	296	O75908
SIQGLYIFLVYAACN	ADGRD2	891	Q7Z7M1
AILCFVAYSIQIYFN	ATP1A4	116	Q13733
NVCFITPQFLYQFYC	ATP11B	886	Q9Y2G3
TPQFLYQFYCLFSQQ	ATP11B	891	Q9Y2G3
FLQNQEGFAIYSEYC	SPATA13	321	Q96N96
YQTFVNFNYCTGILG	TRIM5	336	Q9C035
YAYVVELCVFTIFGN	ZDHHC20	31	Q5W0Z9
LTNFEQGYYQCTAIN	VSIG1	201	Q86XK7
NRYFTFSGICQYLLA	VWF	401	P04275
SLGFRYCAILNAVNY	RINT1	531	Q6NUQ1
NVTGNQDICYYNFLC	SIDT1	471	Q9NXL6
YCNVANAFLVAPQIY	TLCD3A	221	Q8TBR7
VNLFAGKFYHCINYT	SCN2A	1356	Q99250
NKVGVNLFYFCIIVY	TMEM104	141	Q8NE00
LCFVAVSFNTYYNVQ	PKD2L2	326	Q9NZM6
QCGKAFRYYQTFQIH	ZNF709	256	Q8N972
AGIQYSVFYFNFEAC	WDR93	601	Q6P2C0
RCNVFIQGFLYAYSI	WASHC4	436	Q2M389
GNTFYVNVSLQCLTY	USP17L7	86	P0C7H9
NIYNLYEQVSYNCFI	RNASEK	96	Q6P5S7
IVTNVGAYILYFFCA	SC5D	36	O75845
FSNYYIAQVQPVFTC	TENT5A	416	Q96IP4
RNIVQQQFCGEYAYV	USP48	206	Q86UV5
FGAVSFYINVVSYLC	TRPV4	466	Q9HBA0
CKLNLQQSGSFQYYF	AGL	81	P35573