Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
Domain	ARM-type_fold	USP34 CLTCL1 NBEAL1 ARMC12 APC2 RTTN ARMC9 BTAF1 CUL7 LYST RYR3 HEATR6 PKP2	5.20e-06	339	155	13	IPR016024
Domain	Eosinophil_major_basic	PRG3 PRG2	6.84e-05	2	155	2	IPR002352
Domain	EMBP_CTLD	PRG3 PRG2	6.84e-05	2	155	2	IPR033816
Domain	RhoGEF	RASGRF1 PLEKHG7 ECT2L PLEKHG1 ARHGEF33	2.52e-04	68	155	5	SM00325
Domain	RhoGEF	RASGRF1 PLEKHG7 ECT2L PLEKHG1 ARHGEF33	2.89e-04	70	155	5	PF00621
Domain	DH_2	RASGRF1 PLEKHG7 ECT2L PLEKHG1 ARHGEF33	2.89e-04	70	155	5	PS50010
Domain	-	RASGRF1 PLEKHG7 ECT2L PLEKHG1 ARHGEF33	3.09e-04	71	155	5	1.20.900.10
Domain	DH-domain	RASGRF1 PLEKHG7 ECT2L PLEKHG1 ARHGEF33	3.09e-04	71	155	5	IPR000219
Domain	ARM-like	ARMC12 APC2 RTTN ARMC9 BTAF1 CUL7 HEATR6 CEP70 PKP2	4.32e-04	270	155	9	IPR011989
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	WHRN FAM91A1 SLC39A10 KLHL32 PLEKHG1 CADPS MCM3AP SLIT1 SENP2 ASB1 SIPA1L2 RUBCN	4.56e-07	407	160	12	12693553
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	DMXL2 ATP8B4 HSPH1 ANKRD62 ATG14 CUL7 SEMA4G NPHP3 SS18L1 GLS SCAPER HELZ2 TASOR	5.28e-07	493	160	13	15368895
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PITPNM2 USP34 EPPK1 CLTCL1 PPP1R3B RTTN HECTD4 TRMT1 BTAF1 LYST PLEKHG1 ZMIZ2 MCM3AP HELZ2 PDZD8 SENP2 ZFYVE26 SIPA1L2 NCK2	8.84e-07	1105	160	19	35748872
Pubmed	Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.	USP34 PSD ECT2L CHD4 CUL7 WDR26 FANCD2 TAF3 VPS52 ARHGEF33 CADPS SS18L1 MCM3AP SCAPER PKP2 HELZ OSMR SIPA1L2 PTCD3	1.02e-06	1116	160	19	31753913
Pubmed	A multi-factor trafficking site on the spliceosome remodeling enzyme BRR2 recruits C9ORF78 to regulate alternative splicing.	AAMP LIMA1 HSPH1 FAM91A1 MYO1B LRRC40 VPS52 GLS PKP2 AFDN VARS1 DYNC1LI2 PTCD3	2.17e-06	560	160	13	35241646
Pubmed	Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.	WHRN CUL7 CADPS MCM3AP SCAPER TASOR MYO16	2.51e-06	130	160	7	12421765
Pubmed	Large-scale characterization of HeLa cell nuclear phosphoproteins.	LIMA1 PDE4C ERCC6L MYO18A FAM91A1 CHD4 BTAF1 FANCD2 TAF3 PAXBP1 MDC1 HELZ2 HELZ AFDN DYNC1LI2	3.22e-06	774	160	15	15302935
Pubmed	Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism.	TRAF5 RPP21 WWOX HSPH1 TRMT1 DNM1L ZDBF2 VPS54 PREPL DIPK2A FANCD2 NBAS CHCHD3 TAF3 VPS52 INTS2 MCM3AP CENPI SCAPER HELZ	3.34e-06	1327	160	20	32694731
Pubmed	Discovery and Characterization of ZUFSP/ZUP1, a Distinct Deubiquitinase Class Important for Genome Stability.	USP34 DMXL2 CHD4 VPS54 VPS52 HELZ2 USP48	5.68e-06	147	160	7	29576527
Pubmed	BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.	DMXL2 WWOX NBEAL1 FAM91A1 VPS54 VPS52 TRIM36 RUBCN NCK2	7.52e-06	285	160	9	34369648
Pubmed	Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.	USP34 DMXL2 HSPH1 APC2 HECTD4 CHD4 VPS54 WDR26 PREPL RYR3 CHCHD3 HEATR6 CADPS GLS CEP70 ZBTB5 PDZD8 AFDN VARS1	7.83e-06	1285	160	19	35914814
Pubmed	An antibody-based proximity labeling map reveals mechanisms of SARS-CoV-2 inhibition of antiviral immunity.	USP34 WWOX ERCC6L ZDBF2 NBAS VPS52 DDHD1 MDC1 PDZD8 HELZ TASOR VARS1 DYNC1LI2 NCK2	8.19e-06	733	160	14	34672954
Pubmed	Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry.	LIMA1 MYO18A DDHD1 AFDN CTNNA2	1.48e-05	67	160	5	29254152
Pubmed	Defining the proximal interaction networks of Arf GTPases reveals a mechanism for the regulation of PLD1 and PI4KB.	USP34 FAM91A1 DNM1L CHD4 SLC39A10 VPS52 FRMD6 ANO6 PKP2 AFDN PRKCH TASOR DYNC1LI2 PTCD3	1.57e-05	777	160	14	35844135
Pubmed	Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.	USP34 DMXL2 HSPH1 MYO1B CHD4 CUL7 SLIT1 PRKCH VARS1	1.98e-05	322	160	9	26514267
Pubmed	A crucial exosome-related gene pair (AAMP and ABAT) is associated with inflammatory cells in intervertebral disc degeneration.	AAMP ABAT	2.10e-05	2	160	2	37122729
Pubmed	ERK/Drp1-dependent mitochondrial fission is involved in the MSC-induced drug resistance of T-cell acute lymphoblastic leukemia cells.	DNM1L MAPK1	2.10e-05	2	160	2	27831567
Pubmed	The deSUMOylase SENP2 coordinates homologous recombination and nonhomologous end joining by independent mechanisms.	MDC1 SENP2	2.10e-05	2	160	2	30796017
Pubmed	Drp1 phosphorylation by MAPK1 causes mitochondrial dysfunction in cell culture model of Huntington's disease.	DNM1L MAPK1	2.10e-05	2	160	2	29397067
Pubmed	Targeting RANKL to a specific subset of murine mammary epithelial cells induces ordered branching morphogenesis and alveologenesis in the absence of progesterone receptor expression.	PGR TNFSF11	2.10e-05	2	160	2	20605949
Pubmed	Human eosinophil major basic protein 2: location of disulfide bonds and free sulfhydryl groups.	PRG3 PRG2	2.10e-05	2	160	2	17136616
Pubmed	Comparative structure, proximal promoter elements, and chromosome location of the human eosinophil major basic protein genes.	PRG3 PRG2	2.10e-05	2	160	2	11170744
Pubmed	Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies.	PITPNM2 DMXL2 ABAT MYO18A FAM91A1 ZDBF2 WDR26 CHCHD3 CADPS GLS TENM1 HELZ AFDN CTNNA2 SIPA1L2 VARS1 PTCD3	2.16e-05	1139	160	17	36417873
Pubmed	C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy.	DMXL2 WWOX SLC39A10 PIGU LYST LRCH3 NBAS BORCS5 ANO6 TENM1 PDZD8	2.37e-05	504	160	11	34432599
Pubmed	New interaction partners for Nek4.1 and Nek4.2 isoforms: from the DNA damage response to RNA splicing.	WHRN LIMA1 TTC16 APC2 SLC39A10 CADPS MDC1 TENM1 OSMR DSE DYNC1LI2	2.79e-05	513	160	11	25798074
Pubmed	Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.	DMXL2 RASGRF1 HSPH1 MYO18A LMTK3 SH2D5 CTNNA2 SIPA1L2 DYNC1LI2	3.55e-05	347	160	9	17114649
Pubmed	Systematic proteomics of endogenous human cohesin reveals an interaction with diverse splicing factors and RNA-binding proteins required for mitotic progression.	LIMA1 MYO1B ZDBF2 BTAF1 WDR26 VPS52 INTS2 CEP70	4.04e-05	272	160	8	31010829
Pubmed	Lymphatic mimicry in maternal endothelial cells promotes placental spiral artery remodeling.	MAPK1 ADGRE1 IL2RG	4.17e-05	15	160	3	31415243
Pubmed	Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method.	USP34 WWOX HSPH1 FAM91A1 DNM1L SLC39A10 KLHL32 NPHP3 PAXBP1 INTS2 DDHD1 RXFP2 MAPK1 TASOR DSE DYNC1LI2	4.35e-05	1084	160	16	11544199
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	CDK16 LIMA1 CUL7 SKP2 LRCH3 PLEKHG1 PKP2 HELZ AFDN SIPA1L2	4.48e-05	446	160	10	24255178
Pubmed	A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins.	LIMA1 MYO18A DNM1L MYO1B	5.55e-05	45	160	4	22114352
Pubmed	Comprehensive interactome profiling of the human Hsp70 network highlights functional differentiation of J domains.	DMXL2 HSPH1 MYO18A LRRC40 SLC39A10 PIGU PREPL PLEKHG1 NBAS CHCHD3 PAXBP1 MTX2 ANO6 GLS PDZD8 SENP2 SIPA1L2 USP48 PTCD3	5.77e-05	1487	160	19	33957083
Pubmed	A High-Density Human Mitochondrial Proximity Interaction Network.	WWOX TRMT1 DNM1L LRRC40 ZDBF2 CUL7 PIGU PREPL FANCD2 NBAS CHCHD3 VPS52 MTX2 GLS THG1L PDZD8 PRKCH SENP2 PTCD3	6.25e-05	1496	160	19	32877691
Pubmed	Echinocystic acid inhibits RANKL-induced osteoclastogenesis by regulating NF-κB and ERK signaling pathways.	TNFSF11 MAPK1	6.29e-05	3	160	2	27349866
Pubmed	TRAF5 functions in both RANKL- and TNFalpha-induced osteoclastogenesis.	TRAF5 TNFSF11	6.29e-05	3	160	2	12619928
Pubmed	Indomethacin impairs mitochondrial dynamics by activating the PKCζ-p38-DRP1 pathway and inducing apoptosis in gastric cancer and normal mucosal cells.	DNM1L MAPK1	6.29e-05	3	160	2	30940726
Pubmed	Identification of CD37, cystatin A, and IL-23A gene expression in association with brain metastasis: analysis of a prospective trial.	IL23A CD37	6.29e-05	3	160	2	30854931
Pubmed	Two distinct mechanisms underlie progesterone-induced proliferation in the mammary gland.	PGR TNFSF11	6.29e-05	3	160	2	20133621
Pubmed	Dendritic cell differentiation with prostaglandin E results in selective attenuation of the extracellular signal-related kinase pathway and decreased interleukin-23 production.	IL23A MAPK1	6.29e-05	3	160	2	20408896
Pubmed	Progesterone receptor and Stat5 signaling cross talk through RANKL in mammary epithelial cells.	PGR TNFSF11	6.29e-05	3	160	2	24014651
Pubmed	Association of genetic markers with CSF oligoclonal bands in multiple sclerosis patients.	MMS22L KLHL32	6.29e-05	3	160	2	23785401
Pubmed	Sustained RANKL response to parathyroid hormone in oncostatin M receptor-deficient osteoblasts converts anabolic treatment to a catabolic effect in vivo.	TNFSF11 OSMR	6.29e-05	3	160	2	22190112
Pubmed	Inhibition of ERK-DLP1 signaling and mitochondrial division alleviates mitochondrial dysfunction in Alzheimer's disease cybrid cell.	DNM1L MAPK1	6.29e-05	3	160	2	24252614
Pubmed	A p53/TIAF1/WWOX triad exerts cancer suppression but may cause brain protein aggregation due to p53/WWOX functional antagonism.	WWOX MYO18A	6.29e-05	3	160	2	31315632
Pubmed	Paracrine-rescued lobulogenesis in chimeric outgrowths comprising progesterone-receptor-null mammary epithelium and redirected wild-type testicular cells.	PGR TNFSF11	6.29e-05	3	160	2	24190884
Pubmed	SENP2 regulated the stability of β-catenin through WWOX in hepatocellular carcinoma cell.	WWOX SENP2	6.29e-05	3	160	2	24969559
Pubmed	Quantitative Proteomics Links the LRRC59 Interactome to mRNA Translation on the ER Membrane.	WWOX PIGU NBAS CHCHD3 ANO6 PKP2 PDZD8 AFDN SENP2	6.46e-05	375	160	9	32788342
Pubmed	Interrogating the protein interactomes of RAS isoforms identifies PIP5K1A as a KRAS-specific vulnerability.	CDK16 FAM91A1 DNM1L MYO1B VPS54 SLC39A10 PIGU CHCHD3 PKP2 AFDN	6.56e-05	467	160	10	30194290
Pubmed	Genome-wide meta-analysis of systolic blood pressure in children with sickle cell disease.	PLEKHG1 TENM1 NCK2	7.41e-05	18	160	3	24058526
Pubmed	Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity.	USP34 HSPH1 MYO1B CHD4 CUL7 SKP2 WDR26 LYST INTS2 RTL1 SCAPER DDX60L MAPK1 NCK2	8.63e-05	910	160	14	36736316
Pubmed	Defining the membrane proteome of NK cells.	CLTCL1 ERCC6L MYO18A DNM1L LRRC40 CHD4 PIGU NBAS INTS2 ANO6 CD37 HELZ2 PDZD8 HELZ IL2RG DYNC1LI2	1.04e-04	1168	160	16	19946888
Pubmed	CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI.	BTAF1 VPS52 HEATR6 MCM3AP HELZ	1.23e-04	104	160	5	31240132
Pubmed	The adaptor protein Nck2 mediates Slit1-induced changes in cortical neuron morphology.	SLIT1 NCK2	1.25e-04	4	160	2	21600986
Pubmed	Progesterone drives mammary secretory differentiation via RankL-mediated induction of Elf5 in luminal progenitor cells.	PGR TNFSF11	1.25e-04	4	160	2	23462470
Pubmed	Induction of progesterone target genes requires activation of Erk and Msk kinases and phosphorylation of histone H3.	PGR MAPK1	1.25e-04	4	160	2	17081988
Pubmed	The synergistic effect of Mig-6 and Pten ablation on endometrial cancer development and progression.	PGR MAPK1	1.25e-04	4	160	2	20418913
Pubmed	Cooperation of ERK and SCFSkp2 for MKP-1 destruction provides a positive feedback regulation of proliferating signaling.	SKP2 MAPK1	1.25e-04	4	160	2	16286470
Pubmed	Pathologically high intraocular pressure induces mitochondrial dysfunction through Drp1 and leads to retinal ganglion cell PANoptosis in glaucoma.	DNM1L MAPK1	1.25e-04	4	160	2	36989574
Pubmed	TIAF1 and p53 functionally interact in mediating apoptosis and silencing of TIAF1 abolishes nuclear translocation of serine 15-phosphorylated p53.	WWOX MYO18A	1.25e-04	4	160	2	14965474
Pubmed	HIV-Tat protein transduction domain specifically attenuates growth of polyamine deprived tumor cells.	PRG3 PRG2	1.25e-04	4	160	2	17308074
Pubmed	p44/42 MAPK activation is necessary for receptor activator of nuclear factor-kappaB ligand induction by high extracellular calcium.	TNFSF11 MAPK1	1.25e-04	4	160	2	12727216
Pubmed	Dual-specificity phosphatase 1 ubiquitination in extracellular signal-regulated kinase-mediated control of growth in human hepatocellular carcinoma.	SKP2 MAPK1	1.25e-04	4	160	2	18519678
Pubmed	Phosphatidic acid (PA)-preferring phospholipase A1 regulates mitochondrial dynamics.	DNM1L DDHD1	1.25e-04	4	160	2	24599962
Pubmed	Protective effects of prepubertal genistein exposure on mammary tumorigenesis are dependent on BRCA1 expression.	PGR TNFSF11	1.25e-04	4	160	2	21680703
Pubmed	Lipopolysaccharide increases IL-6 secretion via activation of the ERK1/2 signaling pathway to up-regulate RANKL gene expression in MLO-Y4 cells.	TNFSF11 MAPK1	1.25e-04	4	160	2	27778412
Pubmed	RANKL and vascular endothelial growth factor (VEGF) induce osteoclast chemotaxis through an ERK1/2-dependent mechanism.	TNFSF11 MAPK1	1.25e-04	4	160	2	14506249
Pubmed	MINOS1 is a conserved component of mitofilin complexes and required for mitochondrial function and cristae organization.	CHCHD3 MTX2 MAPK1	1.58e-04	23	160	3	22114354
Pubmed	Global phosphoproteome of HT-29 human colon adenocarcinoma cells.	LIMA1 EPPK1 HSPH1 MYO18A	1.61e-04	59	160	4	16083285
Pubmed	Genetic determinants influencing human serum metabolome among African Americans.	UGT1A10 ACY3 PKD2L1	1.80e-04	24	160	3	24625756
Pubmed	A protein interaction landscape of breast cancer.	CDK16 EPPK1 HSPH1 MYO18A MYO1B CUL7 HEATR6 MTX2 FRMD6 CTNNA2 PTCD3	1.82e-04	634	160	11	34591612
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	CDK16 LIMA1 ERCC6L DNM1L WDR26 LYST PLEKHG1 BORCS5 FRMD6 PKP2 HELZ AFDN SIPA1L2	1.86e-04	861	160	13	36931259
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	AAMP ERCC6L ATG14 ZDBF2 PIGU PREPL FER1L6 CHCHD3 DDHD1 SS18L1 GLS	1.92e-04	638	160	11	31182584
Pubmed	Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.	EPPK1 WWOX ERCC6L DNM1L SLC39A10 WDR26 VPS52 MTX2 MAPK1 DYNC1LI2	1.93e-04	533	160	10	25544563
Pubmed	LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells.	EPPK1 CLTCL1 CUL7 LRCH3 CEP70 PKP2 HELZ CTNNA2 MAPK1 SIPA1L2 PTCD3	1.94e-04	639	160	11	23443559
Pubmed	Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.	MYO18A TRMT1 SLC39A10 WDR26 DIPK2A LRCH3 FANCD2 HEATR6 INTS2 ANO6 PKP2 MAPK1	2.05e-04	754	160	12	33060197
Pubmed	Selective regulation of osteoblastic OPG and RANKL by dehydroepiandrosterone through activation of the estrogen receptor β-mediated MAPK signaling pathway.	TNFSF11 MAPK1	2.08e-04	5	160	2	22556124
Pubmed	Functional characterization and chromosomal localization of a cloned taurine transporter from human placenta.	AAMP PDE4C	2.08e-04	5	160	2	8010975
Pubmed	Characterization of the human GARP (Golgi associated retrograde protein) complex.	VPS54 VPS52	2.08e-04	5	160	2	15878329
Pubmed	Requirement of the human GARP complex for mannose 6-phosphate-receptor-dependent sorting of cathepsin D to lysosomes.	VPS54 VPS52	2.08e-04	5	160	2	18367545
Pubmed	Contribution of NK cells to the innate phase of host protection against an intracellular bacterium targeting systemic endothelium.	LYST IL2RG	2.08e-04	5	160	2	22617213
Pubmed	The GARP Complex Is Involved in Intracellular Cholesterol Transport via Targeting NPC2 to Lysosomes.	VPS54 VPS52	2.08e-04	5	160	2	28658628
Pubmed	Genetic modifiers that aggravate the neurological phenotype of the wobbler mouse.	VPS54 TNFSF11	2.08e-04	5	160	2	11930176
Pubmed	Caveolin-1 interferes cell growth of lung cancer NCI-H446 cell through the interactions with phospho-ERK1/2, estrogen receptor and progestin receptor.	PGR MAPK1	2.08e-04	5	160	2	22564243
Pubmed	Mig-6 Mouse Model of Endometrial Cancer.	PGR MAPK1	2.08e-04	5	160	2	27910070
Pubmed	Exacerbation of pathogenic Th17-cell-mediated cutaneous graft-versus-host-disease in human IL-1β and IL-23 transgenic humanized mice.	IL23A IL2RG	2.08e-04	5	160	2	31230747
Pubmed	The Effect of and Mechanism Underlying Autophagy in Hepatocellular Carcinoma Induced by CH12, a Monoclonal Antibody Directed Against Epidermal Growth Factor Receptor Variant III.	ATG14 RUBCN	2.08e-04	5	160	2	29587298
Pubmed	ORF3a-Mediated Incomplete Autophagy Facilitates Severe Acute Respiratory Syndrome Coronavirus-2 Replication.	ATG14 RUBCN	2.08e-04	5	160	2	34386498
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	USP34 EPPK1 MYO1B CHD4 CUL7 MCM3AP MDC1 HELZ2 HELZ AFDN PTCD3	2.34e-04	653	160	11	22586326
Pubmed	Next-generation sequencing to generate interactome datasets.	AAMP TRAF5 ACY3 TRMT1 CHCHD3 VPS52 PLPP1 FRMD6 SS18L1 THG1L CEP70 ZFYVE26 ABHD16A NCK2 PTCD3	2.83e-04	1147	160	15	21516116
Pubmed	Dapper1 promotes autophagy by enhancing the Beclin1-Vps34-Atg14L complex formation.	ATG14 RUBCN	3.12e-04	6	160	2	24980960
Pubmed	Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities.	SKP2 MAPK1	3.12e-04	6	160	2	14592976
Pubmed	Regulation of Beclin 1 in autophagy.	ATG14 RUBCN	3.12e-04	6	160	2	19372752
Pubmed	The RUN domain of rubicon is important for hVps34 binding, lipid kinase inhibition, and autophagy suppression.	ATG14 RUBCN	3.12e-04	6	160	2	21062745
Pubmed	The neuropeptide VIP confers anticipatory mucosal immunity by regulating ILC3 activity.	VIPR2 IL2RG	3.12e-04	6	160	2	31873294
Pubmed	Uterine glands impact embryo survival and stromal cell decidualization in mice.	PGR ADGRE1	3.12e-04	6	160	2	34547143
Pubmed	Hyaluronan activates Hyal-2/WWOX/Smad4 signaling and causes bubbling cell death when the signaling complex is overexpressed.	WWOX MAPK1	3.12e-04	6	160	2	27845895
Pubmed	MDC1 is required for the intra-S-phase DNA damage checkpoint.	FANCD2 MDC1	3.12e-04	6	160	2	12607003
Pubmed	An association study between polymorphisms in five genes in glutamate and GABA pathway and paranoid schizophrenia.	ABAT GLS	3.12e-04	6	160	2	15642443
Pubmed	Identification of a new murine eosinophil major basic protein (mMBP) gene: cloning and characterization of mMBP-2.	PRG3 PRG2	3.12e-04	6	160	2	10770291
Pubmed	TSSC1 is novel component of the endosomal retrieval machinery.	VPS54 VPS52	3.12e-04	6	160	2	27440922
Interaction	FIS1 interactions	FAM91A1 DNM1L FANCD2 NBAS HEATR6 MTX2 PDZD8 PRKCH SENP2 ZFYVE26 USP48	1.24e-06	221	156	11	int:FIS1
Cytoband	5q12	GCNT4 CD180	1.79e-04	6	160	2	5q12
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	ARMC12 APC2 ARMC9 PKP2	1.48e-04	43	113	4	409
GeneFamily	Fibronectin type III domain containing	PTPRH PTPRQ OSMR TRIM36 ANKFN1 IL2RG	5.07e-04	160	113	6	555
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	RASGRF1 ECT2L PLEKHG1 ARHGEF33	7.74e-04	66	113	4	722
GeneFamily	WD repeat domain containing\|BEACH domain containing	NBEAL1 LYST	1.35e-03	9	113	2	1230
GeneFamily	UPF1 like RNA helicases	HELZ2 HELZ	2.05e-03	11	113	2	1169
GeneFamily	PDZ domain containing	WHRN MYO18A PDZD8 AFDN SIPA1L2	2.66e-03	152	113	5	1220
ToppCell	droplet-Lung-nan-21m-Myeloid-Plasmacytoid_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBXL13 RASGRF1 SH2D5 PRG2 ZMIZ2 CD180 IL17RB	3.13e-06	173	160	7	8fb32a9f2dbec16de840d55b4db7e7718f5a2a7a
ToppCell	droplet-Lung-nan-21m-Myeloid-plasmacytoid_dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	FBXL13 RASGRF1 SH2D5 PRG2 ZMIZ2 CD180 IL17RB	3.13e-06	173	160	7	f663571aaae2365660a8b526c355f4bd1a124a74
ToppCell	droplet-Lung-nan-21m-Myeloid-Ccr7+_Dendritic\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	LRRC40 SH2D5 RYR3 TNFSF11 PRG3 PRG2 PKP2	3.92e-06	179	160	7	d78eacf47847a50888dd16c35bed9b7afc80010f
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Hematopoietic-T_cells-ILCP\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ATP8B4 KLHL32 IL23A SERPINA11 TNFSF11 CD37 IL2RG	4.07e-06	180	160	7	ca7c316027e31559103b2cab1a2c0de993e42e95
ToppCell	10x3'2.3-week_14-16-Lymphocytic_NK-T_NK-ILC_precursor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	ACP6 TRAF5 SERPINA11 TNFSF11 PRKCH CTNNA2 IL2RG	4.07e-06	180	160	7	27672ac6a02172a31851f18decb9acffa8f5a703
ToppCell	5'-GW_trimst-1.5-LargeIntestine-Hematopoietic-T_cells\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ATP8B4 KLHL32 IL23A SERPINA11 TNFSF11 CD37 IL2RG	4.07e-06	180	160	7	eb26ba86fba26899e54c448afc25382ddc853013
ToppCell	10x5'v1-week_14-16-Lymphocytic_NK-T_NK-ILC_precursor\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	WHRN GPR82 IL23A SERPINA11 TNFSF11 PRKCH IL2RG	4.07e-06	180	160	7	a999a6d219a8e58a8b63802ddf8c95ffaab9cfa0
ToppCell	Hippocampus-Macroglia-CSF_related-EPENDYMAL-Ependymal.Ccdc153_(Ccdc153)\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ATP8B4 FBXL13 ECT2L UNC5CL CCDC180 ANKFN1	4.16e-06	117	160	6	91936a3ffbfa29024ced9d01df962b4ccfaf8966
ToppCell	Hippocampus-Macroglia-CSF_related-EPENDYMAL-Ependymal.Ccdc153_(Ccdc153)-\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ATP8B4 FBXL13 ECT2L UNC5CL CCDC180 ANKFN1	4.16e-06	117	160	6	e33ec9044541d2ef53f6633891238559b01b7957
ToppCell	Hippocampus-Macroglia-CSF_related-EPENDYMAL-Ependymal.Ccdc153_(Ccdc153)--\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ATP8B4 FBXL13 ECT2L UNC5CL CCDC180 ANKFN1	4.16e-06	117	160	6	454efceabe739cdf293f81c8a938811f12321a47
ToppCell	Hippocampus-Macroglia-CSF_related-EPENDYMAL\|Hippocampus / BrainAtlas - Mouse McCarroll V32	ATP8B4 FBXL13 ECT2L UNC5CL CCDC180 ANKFN1	4.16e-06	117	160	6	409b3ab16786bced8c9bc9c0e89b0078402f365a
ToppCell	CV-Moderate-7\|Moderate / Virus stimulation, Condition and Cluster	DMXL2 MMS22L ATP8B4 TMEM161B DIPK2A NBAS DDHD1	4.87e-06	185	160	7	a6c9203ce6c2892a4a369c9bcfb85720f01cbb3f
ToppCell	CV-Moderate-7\|CV / Virus stimulation, Condition and Cluster	DMXL2 MMS22L ATP8B4 TMEM161B DIPK2A NBAS DDHD1	5.04e-06	186	160	7	8571956890fc9894d766ba294a28e376b4aba428
ToppCell	10x3'2.3-week_14-16-Lymphocytic_NK-T_NK\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	WHRN TRAF5 TTC16 SERPINA11 PRKCH CTNNA2 IL2RG	5.80e-06	190	160	7	67fa7472ec534179087963177351552cc3c335eb
ToppCell	10x3'2.3-week_14-16-Lymphocytic_NK\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	WHRN TRAF5 TTC16 SERPINA11 PRKCH CTNNA2 IL2RG	5.80e-06	190	160	7	094efcde2b037ae509298abb8b2b1d52f9c86a45
ToppCell	CD8+_Memory_T_cell-CV-7\|CD8+_Memory_T_cell / cell class, Virus stimulation and cluster	MMS22L ATP8B4 TMEM161B LYST DIPK2A NBAS DDHD1	6.00e-06	191	160	7	9454f642c3621370fa23640b631301346b300950
ToppCell	mild-low-quality_cells\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	USP34 RTTN BTAF1 DDHD1 GLS TENM1 PRKCH	7.85e-06	199	160	7	f0b0097df0026496470a80d8cc9375ffd8389b00
ToppCell	Sigmoid-T_cell-Tfh\|T_cell / Region, Cell class and subclass	FBXL13 CDKL3 FAM91A1 ECT2L SKP2 KLHL32 HELZ2	8.11e-06	200	160	7	dd7dcf25520f065bf0d33d589f3c176f63875dc9
ToppCell	COVID-19-Mast_cells-Monocyte-derived_macrophages\|COVID-19 / group, cell type (main and fine annotations)	GPR82 NPHP3 CADPS ADGRE1 CD180 TRIM36	1.73e-05	150	160	6	10697c2d22cb25376827cc7c570ff1adc94c1acd
ToppCell	LAM-Lymphoid-B-cell-2\|LAM / Condition, Lineage and Cell class	WHRN ACY3 C2orf88 TGFBR3L UGT3A2 CD180	2.48e-05	160	160	6	0060c2b3304f411c682aa2ba20bcf80f346d2403
ToppCell	droplet-Lung-nan-21m-Myeloid-dendritic_cell\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	GPR82 SH2D5 RYR3 TNFSF11 PRG3 PRG2	3.61e-05	171	160	6	159ce6d5513008532dd7785b915b3fe7440cc4b2
ToppCell	facs-Large_Intestine-Distal-18m-Epithelial-Brush_cell_of_epithelium_proper_of_large_intestine\|Large_Intestine / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DMXL2 EPPK1 ANO6 TENM1 CD180 IL17RB	4.10e-05	175	160	6	f24b664b9056b5976bf2222e8013f15c09e049ad
ToppCell	BAL-Control-Myeloid-cDC-cDC-cDC_6\|Control / Location, Disease Group, Cell group, Cell class and sub_cluster (2021.03.01)	ATP8B4 FBXL13 ACY3 MYO1B IDO2 CD180	4.37e-05	177	160	6	3a150dcaefa342d49968b42c7cdb1fbb633adcd0
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma\|TCGA-Brain / Sample_Type by Project: Shred V9	MYO18A KLHL32 TAF3 SCAPER PDZD8 ASB1	4.37e-05	177	160	6	e8ab340b20cd41554c3841fe980e078e878af35f
ToppCell	B_cells-Naive_B_cells_\|B_cells / Immune cells in Kidney/Urine in Lupus Nephritis	ABAT HECTD4 PLEKHG1 CD37 DSE NCK2	4.51e-05	178	160	6	71ac2eca5cf13a91f86b80690748b0788392dcfc
ToppCell	Primary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5\|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GABRG1 VIPR2 PKD2L1 PLEKHG1 SLIT1 CTNNA2	4.51e-05	178	160	6	731e1e8eff2c4018c75dfc66632a316010a09a9a
ToppCell	droplet-Heart-HEART-1m-Mesenchymal-coronary_vascular_endothelial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WHRN CDKL3 ECT2L DIPK2A SS18L1 RUBCN	4.66e-05	179	160	6	dd94ebe69ade6f51b94058abe066216f0de9feda
ToppCell	3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.3.0\|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	WHRN EPPK1 FBXL13 AFDN CCDC180 ANKFN1	4.80e-05	180	160	6	92fb01b91261b3103454924cde56add337b41844
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-ependymal_cell\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPPK1 FBXL13 TTC16 UNC5CL RXFP2 CCDC180	5.11e-05	182	160	6	587636c0f127231de21acd8aa632b74ff22ca8c2
ToppCell	5'-Airway_Nasal-Immune_Myeloid_mast-Myeloid_Mast/Baso-mast_cell-Mast_cells-\|5' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5	ATP8B4 TGFBR3L DNM1L CADPS PRG2 MYO16	5.11e-05	182	160	6	4cd5eb13f78f4f377932c50ac2acb4ac0cd14c12
ToppCell	COPD-Myeloid-Mast\|World / Disease state, Lineage and Cell class	ATP8B4 GCNT4 RYR3 NBAS CADPS MAPK1	5.11e-05	182	160	6	68a1e7b804f309bfd6c23d65fad20a9a962712ae
ToppCell	facs-Brain_Non-Myeloid-Cerebellum-3m-Mesenchymal-Ependyma\|Brain_Non-Myeloid / Brain_Non-Myeloid_Brain_Myeloid - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPPK1 FBXL13 TTC16 UNC5CL RXFP2 CCDC180	5.11e-05	182	160	6	adfadd7893e74b3002f13f00875e3667d3493e0c
ToppCell	Mid-temporal_gyrus_(MTG)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5\|Mid-temporal_gyrus_(MTG) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	GABRG1 VIPR2 PKD2L1 KLHL32 PLEKHG1 SLIT1	5.26e-05	183	160	6	b5d041d0a3506c33de72bf14fa0443f4410fddf1
ToppCell	TCGA-Liver-Primary_Tumor-Hepatocellular_Carcinoma-Hepatocellular_Carcinoma-5\|TCGA-Liver / Sample_Type by Project: Shred V9	MMS22L ERCC6L FANCD2 DDHD1 CENPI USP48	5.26e-05	183	160	6	f604a8b62c7088fad8365dbf8d910fc980bd3ba8
ToppCell	5'-GW_trimst-2-LymphNode-Hematopoietic-T_cells-ILCP\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	WHRN SERPINA11 TNFSF11 CD37 PRKCH IL2RG	5.26e-05	183	160	6	4a1e5bf58d2acd9dbceeef538b6851c1e5e91059
ToppCell	wk_08-11-Hematologic_Lymphocytic-T_&_ILC-ILCP\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	ATP8B4 SERPINA11 TNFSF11 CD37 PRKCH IL2RG	5.26e-05	183	160	6	797eb968c57e48db33ff8e2236ee22e9425c4676
ToppCell	wk_08-11-Hematologic_Lymphocytic-T_&_ILC\|wk_08-11 / Celltypes from embryonic and fetal-stage human lung	ATP8B4 SERPINA11 TNFSF11 CD37 PRKCH IL2RG	5.43e-05	184	160	6	51ae0963b4fb034c3f605ee4e5da513cba7aca35
ToppCell	control-Myeloid-Eosinophils\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	ATP8B4 ZDBF2 SLC39A10 GCNT4 TNFSF11 IL17RB	5.43e-05	184	160	6	fad517d047e8eaeaa5bd4f311d770880568dd13c
ToppCell	COPD-Myeloid-Mast\|COPD / Disease state, Lineage and Cell class	ATP8B4 GCNT4 RYR3 NBAS CADPS MAPK1	5.76e-05	186	160	6	def6f0f284acc2154738574c8c5d3d2a5ef1f208
ToppCell	facs-Mammary_Gland-Mammary_Gland-21m-Epithelial-luminal_epithelial_cell_of_mammary_gland\|Mammary_Gland / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation	RASGRF1 TTC16 PKD2L1 PGR TNFSF11 ANKFN1	5.76e-05	186	160	6	02fbb02c495e7d64c4ab50e42e5197782f2c0816
ToppCell	5'-GW_trimst-1.5-SmallIntestine-Hematopoietic-T_cells-ILCP\|GW_trimst-1.5 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	IL23A SERPINA11 TNFSF11 CD37 PRKCH IL2RG	5.76e-05	186	160	6	428b4cbee3d3ab666cab2fc2d9c815318359e458
ToppCell	10x5'v1-week_12-13-Lymphocytic_T-T_NK-NK_T_cell\|week_12-13 / cell types per 3 fetal stages;per 3',per 5'	TRAF5 TTC16 ZBTB5 PRKCH IL2RG IL17RB	5.76e-05	186	160	6	b099cb0902e9afb11218d70407d3cab212343c6d
ToppCell	10x5'v1-week_14-16-Lymphocytic_T-T_NK-CD8_T_cell\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	TRAF5 TTC16 IL23A TENM1 PRKCH IL2RG	6.29e-05	189	160	6	347dea83d0c612341c1ef6e5df5e369520f0a0a4
ToppCell	mild-Myeloid-Immature_Neutrophils_1\|Myeloid / Cohort 2 (Rhapsody WB + PBMC) with disease condition, lineage and cell classs	ACP6 ATP8B4 CLTCL1 VPS54 FIGN PAXBP1	6.29e-05	189	160	6	94dd5d4d815449feff7ce157fe7f8234f7c81422
ToppCell	COPD-Myeloid-Mast\|Myeloid / Disease state, Lineage and Cell class	ATP8B4 GCNT4 RYR3 NBAS CADPS MAPK1	6.48e-05	190	160	6	379dbac19110b76079a7a53209569e060a852acb
ToppCell	human_hepatoblastoma-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	WWOX HSPH1 VPS54 HELZ AFDN IL17RB	6.87e-05	192	160	6	916fbec1c7ab7969bda711886ac88e877e30c280
ToppCell	systemic_lupus_erythematosus-managed-Lymphocytic_B-B_mem-male\|systemic_lupus_erythematosus / PBMC cell types (v2) per disease, treatment status, and sex	TRAF5 NBEAL1 PLEKHG7 PLEKHG1 RTL1 CD37	6.87e-05	192	160	6	185dd150d3345cd29625052a46f3ed89f2a9a8f6
ToppCell	10x5'v1-week_17-19-Lymphocytic_B-B_lineage-naive_B_cell\|week_17-19 / cell types per 3 fetal stages;per 3',per 5'	TRAF5 LMTK3 PLEKHG1 CD37 CD180 IL2RG	6.87e-05	192	160	6	5d6569b0f879729aa89d4498c9c886ac9050be13
ToppCell	3'-GW_trimst-2-SmallIntestine-Hematopoietic-T_cells-LTi-like_NCR-_ILC3\|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	GPR82 IL23A SERPINA11 CD37 PRKCH IL2RG	7.07e-05	193	160	6	d8e6a7f1da4506acaa06380b4aec3fe299ec8b7e
ToppCell	facs-Thymus-nan-3m-Lymphocytic-DN_to_DP_transition_(most_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	WHRN PPP1R3B HECTD4 LYST ANO6 NCK2	7.07e-05	193	160	6	a6a864644e1b80b7417ea0a27281e79068a3fd3d
ToppCell	human_hepatoblastoma\|World / Sample and Cell Type and Tumor Cluster (all cells)	WWOX HSPH1 VPS54 HELZ AFDN IL17RB	7.07e-05	193	160	6	e6a688bc834f845ff64dae1be64f073eec5091a1
ToppCell	Hippocampus-Neuronal\|Hippocampus / BrainAtlas - Mouse McCarroll V32	USP34 DNM1L LMTK3 SH2D5 PGR GLS	7.27e-05	194	160	6	8aeb347b3024354c9505f4f0fddf0b843489dc6b
ToppCell	10x5'v1-week_14-16-Hematopoietic-MK-early_MK\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	LIMA1 C2orf88 RYR3 PKP2 PDZD8 ABHD16A	7.48e-05	195	160	6	9b4f217325afb2efb9c65f298ac87649cb1e1af9
ToppCell	Control-Neu_4\|Control / 5 Neutrophil clusters in COVID-19 patients	ATP8B4 TRMT1 FANCD2 CENPI ALKBH3 TASOR	7.69e-05	196	160	6	b8b7b54ca17a08fa775507bb22b1c7248ada8f40
ToppCell	proximal-3-Hematologic-Plasma\|3 / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	WHRN C2orf88 TGFBR3L IL23A UGT3A2 IL2RG	7.69e-05	196	160	6	1ca453582b5db8f1ea20a846e698c54edf0a1f25
ToppCell	proximal-Hematologic-Plasma-3\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	WHRN C2orf88 TGFBR3L IL23A UGT3A2 IL2RG	7.69e-05	196	160	6	f6e842b18765c2d923706cabb5d17efeff1da5aa
ToppCell	proximal-Hematologic-Plasma\|proximal / Location, Lineage, Cell class (ontology) and Donor from 10X sequencing (macrophage renamed)	WHRN C2orf88 TGFBR3L IL23A UGT3A2 IL2RG	7.69e-05	196	160	6	621f112a71f3d82fd75da8addfb16d86f590fe33
ToppCell	control-Treg\|control / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	LIMA1 GPR82 GCNT4 PRKCH IL2RG NCK2	7.91e-05	197	160	6	a80674a0b996aa57d52bfff7264c57caf4c31cc6
ToppCell	LPS_only-Epithelial_airway-airway_epithelial-Ciliated\|LPS_only / Treatment groups by lineage, cell group, cell type	FBXL13 TTC16 PLEKHG7 ARHGEF33 CCDC180 ANKFN1	8.14e-05	198	160	6	6d90b541fde357fbb40f8f7d4e8628a48b679718
ToppCell	COVID-19-COVID-19_Mild-Myeloid-immature_Neutrophil\|COVID-19_Mild / Disease, condition lineage and cell class	CLTCL1 ARMC9 FANCD2 CENPI PDZD8 MYO16	8.36e-05	199	160	6	e222b90caf45904d8f763574e7b6aac13333df92
ToppCell	Parenchymal-10x3prime_v2-Immune_Lymphocytic-B-B_cell-B_mature\|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations	TRAF5 ACY3 HSPH1 IL23A CD37 CD180	8.36e-05	199	160	6	074f21a0075ff6c8e634dc4b12699d371d5f720a
ToppCell	Neuronal-Excitatory-eC(RORB)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	GABRG1 VIPR2 PKD2L1 PLEKHG1 SLIT1 CTNNA2	8.60e-05	200	160	6	8c803a0ce25e140b46036f6aabefc5502601f408
ToppCell	COVID-19-COVID-19_Severe-Lymphocyte-T/NK-dn_T\|COVID-19_Severe / Disease, condition lineage and cell class	LIMA1 TRAF5 GPR82 IL23A LYST TENM1	8.60e-05	200	160	6	d01aa5fccada22f97d8350ad5888df2aadb5bb1c
ToppCell	LPS_IL1RA-Epithelial_airway-airway_epithelial-Ciliated\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	TTC16 ACY3 ECT2L KLHL32 CCDC180 ANKFN1	8.60e-05	200	160	6	4992dbf0514d674017315dbd20d91dfec0c608e9
ToppCell	mild\|World / Cohort 1 (10x PBMC) with disease condition, cell group and cell class	USP34 BTAF1 PAXBP1 HELZ2 HELZ DDX60L	8.60e-05	200	160	6	12f1685ce8f218433068e090c9d839cd5a1910bf
ToppCell	Fetal_brain-organoid_Tanaka_cellReport-GW12-Macroglial\|GW12 / Sample Type, Dataset, Time_group, and Cell type.	PDE4C FBXL13 TGFBR3L GCNT4 FRMD6 HELZ2	8.60e-05	200	160	6	be1abe5bb1ce4e7dfec63af4ed0fc5b96bf77866
ToppCell	VE-CD4-CD4_Treg\|VE / Condition, Cell_class and T cell subcluster	PLEKHG7 APC2 LMTK3 FANCD2 HELZ2	1.03e-04	129	160	5	e89d414e1b23e1656747defa39f09b51944a2166
ToppCell	TCGA-Peripheral_Nervous_System-Primary_Tumor-Paraganglioma-Paraganglioma-3\|TCGA-Peripheral_Nervous_System / Sample_Type by Project: Shred V9	ABAT BTAF1 SKP2 AFDN DYNC1LI2	1.28e-04	135	160	5	ac20133d4a36f48338b45bffb13e842cb66f83ad
ToppCell	PND01-03-samps-Mesenchymal-Matrix_fibroblast-matrix_-_mature_3\|PND01-03-samps / Age Group, Lineage, Cell class and subclass	SKP2 SH2D5 LRCH3 SLC39A12 MTX2	1.37e-04	137	160	5	9bfdbc102cdd861996b3c4eac35b606be8af97eb
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Dlk1_(Zona_Incerta,_ventral_part_(ZIV)_and/or_Lateral_hypothalamus_(LH))-\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	FBXL13 FER1L6 RXFP2 ANKFN1	1.39e-04	73	160	4	cfb3d5bbb1d2b6d228c2cfbdc14e6f70860fe1f2
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Dlk1_(Zona_Incerta,_ventral_part_(ZIV)_and/or_Lateral_hypothalamus_(LH))--\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	FBXL13 FER1L6 RXFP2 ANKFN1	1.39e-04	73	160	4	23e4ed235e75c7cf2807bd0dda56be7744d0fca0
ToppCell	Entopeduncular-Neuronal-Inhibitory-iN1(Gad1Gad2_Th)-Inhibitory_Neuron.Gad1Gad2.Dlk1_(Zona_Incerta,_ventral_part_(ZIV)_and/or_Lateral_hypothalamus_(LH))\|Entopeduncular / BrainAtlas - Mouse McCarroll V32	FBXL13 FER1L6 RXFP2 ANKFN1	1.39e-04	73	160	4	93f1a39aeb4859c2d7c821ce0ebafb7b7a9d81d4
Disease	diastolic blood pressure, alcohol drinking	HECTD4 FIGN PLEKHG1 SLC39A12 SLIT1 TRIM36	3.60e-05	118	153	6	EFO_0004329, EFO_0006336
Disease	Global developmental delay	ABAT APC2 TRMT1 PIGU NBAS CTNNA2	7.03e-05	133	153	6	C0557874
Disease	urate measurement, bone density	VIPR2 DDX12P WWOX UGT1A10 PREPL HEATR6 BORCS5 CEP70 HELZ2 ALKBH3 CTNNA2 MYO16	9.84e-05	619	153	12	EFO_0003923, EFO_0004531
Disease	Intellectual Disability	CDK16 APC2 RTTN TRMT1 ARMC9 PIGU WDR26 PREPL SCAPER CTNNA2	1.20e-04	447	153	10	C3714756
Disease	complex cortical dysplasia with other brain malformations (is_implicated_in)	APC2 CTNNA2	1.59e-04	4	153	2	DOID:0090131 (is_implicated_in)
Disease	mean arterial pressure, alcohol drinking	HECTD4 FIGN PLEKHG1 SLIT1 TRIM36	1.62e-04	98	153	5	EFO_0004329, EFO_0006340
Disease	Alzheimer disease	ATP8B4 FBXL13 PPP1R3B FANCD2 PLEKHG1 UNC5CL CTNNA2 SIPA1L2 MYO16 NCK2	2.32e-04	485	153	10	MONDO_0004975
Disease	Hallux valgus	MYO1B UNC5CL SLIT1 ANKFN1	2.70e-04	60	153	4	HP_0001822
Disease	aspartate aminotransferase measurement	WHRN PPP1R3B PLEKHG7 HECTD4 PKD2L1 NUBP1 ARMC9 PIGU GCNT4 SLC39A12 NPHP3 BORCS5 CTNNA2 VARS1	2.71e-04	904	153	14	EFO_0004736
Disease	HETE measurement	WWOX FAM91A1 FER1L6 NBAS	3.07e-04	62	153	4	EFO_0801166
Disease	cognitive function measurement	USP34 DMXL2 MMS22L WWOX TMEM161B CDKL3 ZDBF2 FIGN GCNT4 KLHL32 RYR3 DIPK2A PLEKHG1 CHCHD3 ZMIZ2 UGT3A2 CTNNA2 TRIM36	4.75e-04	1434	153	18	EFO_0008354
Disease	recalcitrant atopic dermatitis	NBAS SCAPER	5.51e-04	7	153	2	EFO_1000651
Disease	amyloid-beta measurement	GRIK5 NBAS ANKRD19P PRG2 HABP2 CTNNA2 ANKFN1 NCK2	5.53e-04	355	153	8	EFO_0005194
Disease	bipolar II disorder	SLIT1 ADGRE1	7.33e-04	8	153	2	EFO_0009964
Disease	proteoglycan 3 measurement	USP34 PRG3	7.33e-04	8	153	2	EFO_0802970
Disease	amino acid measurement	GABRG1 ABAT CLTCL1 WWOX GRIK5 RYR3 DIPK2A NBAS SLIT1 RXFP2 MYO16	8.54e-04	678	153	11	EFO_0005134
Disease	daytime rest measurement	WWOX C2orf88 FIGN PREPL CADPS HELZ2 ZBTB5	9.10e-04	295	153	7	EFO_0007828
Disease	pulmonary function measurement, forced expiratory volume	WWOX ZSCAN31 ASB1	9.33e-04	37	153	3	EFO_0003892, EFO_0004314
Disease	campesterol measurement	PREPL ANKFN1	1.42e-03	11	153	2	EFO_0020008
Disease	aspartate aminotransferase to alanine aminotransferase ratio	WHRN PDE4C EPPK1 PKD2L1 GCNT4 SLC39A12	1.59e-03	239	153	6	EFO_0010934
Disease	DEAFNESS, AUTOSOMAL RECESSIVE (disorder)	DMXL2 PTPRQ	2.01e-03	13	153	2	C1846647
Disease	putamen volume change measurement	TAF3 MYO16	2.01e-03	13	153	2	EFO_0021495
Disease	autosomal dominant polycystic kidney disease (implicated_via_orthology)	PKD2L1 NPHP3	2.33e-03	14	153	2	DOID:898 (implicated_via_orthology)
Disease	neuritic plaque measurement	VIPR2 GRIK5 RYR3 CHCHD3 PRG2 SLIT1 NCK2	2.37e-03	349	153	7	EFO_0006798
Disease	urate measurement	USP34 PDE4C ZSCAN31 HECTD4 PIGU MTX2 ANO6 UNC5CL SCAPER SENP2 HABP2 VARS1	2.51e-03	895	153	12	EFO_0004531
Disease	mean platelet volume	PITPNM2 ATP8B4 RTTN TRMT1 PKD2L1 DNM1L ATG14 ZMIZ2 DDHD1 GLS TASOR DSE NCK2	2.60e-03	1020	153	13	EFO_0004584
Disease	pathological myopia	VIPR2 PPP1R3B CHD4 DIPK2A	2.71e-03	111	153	4	EFO_0004207
Disease	diastolic blood pressure, alcohol consumption measurement	HECTD4 FIGN PLEKHG1	2.79e-03	54	153	3	EFO_0006336, EFO_0007878
Disease	alcohol use disorder (implicated_via_orthology)	VIPR2 PSD PPP1R3B RYR3 PRKCH	3.56e-03	195	153	5	DOID:1574 (implicated_via_orthology)
Disease	bipolar disorder, sex interaction measurement	SLIT1 SIPA1L2	3.87e-03	18	153	2	EFO_0008343, MONDO_0004985
Disease	lysophosphatidylcholine 22:6 measurement	WWOX SIPA1L2	3.87e-03	18	153	2	EFO_0010365
Disease	response to clozapine	SLC39A12 CTNNA2	3.87e-03	18	153	2	GO_0097338
Disease	lymphocyte count	MMS22L LIMA1 EPPK1 WWOX HECTD4 PKD2L1 GRIK5 LYST BORCS5 PTPRH PRG2 MCM3AP HELZ DDX60L ADGRE1 VARS1	3.97e-03	1464	153	16	EFO_0004587
Disease	colorectal cancer, inflammatory bowel disease	ATP8B4 GRIK5	4.31e-03	19	153	2	EFO_0003767, MONDO_0005575
Disease	temporal lobe epilepsy (is_marker_for)	RASGRF1 GRIK5	4.77e-03	20	153	2	DOID:3328 (is_marker_for)
Disease	common carotid intimal medial thickness	MMS22L RYR3 CD180	5.14e-03	67	153	3	EFO_0004860
Disease	Calcium channel blocker use measurement	USP34 FIGN PLEKHG1 RXFP2 TRIM36	5.16e-03	213	153	5	EFO_0009930

Protein segments in the cluster

Peptide	Gene	Start	Entry
AFKYLVHCLQSELNN	AFDN	726	P55196
RHLQLQYPELSCQVF	ACY3	141	Q96HD9
RIIQHCSNYSTQELL	DNM1L	441	O00429
LAIYDLATQTLRHQC	AAMP	341	Q13685
LNANILYLCFSQHVN	ATG14	351	Q6ZNE5
LYLCFSQHVNLDQLQ	ATG14	356	Q6ZNE5
LFQILRAIDYLHSNN	CDKL3	106	Q8IVW4
AYHNLQCFRLLLLAG	ASB1	201	Q9Y576
HLNLNNAEQLCRYQG	ABHD16A	406	O95870
HTFNSLLCNLYRNEK	ALKBH3	171	Q96Q83
HYTLLFQCNEDLLIQ	ARHGEF33	436	A8MVX0
YQLLQHNIDVFCQDI	ANKRD62	221	A6NC57
NRYLIRVQDVAQLHC	ECT2L	781	Q008S8
QFQRVANAYFLCLLI	ATP8B4	51	Q8TF62
NQDLLRVFLSYCSLH	DMXL2	2151	Q8TDJ6
ANKYHNSCLIELRIQ	CCDC180	1431	Q9P1Z9
FQNLHFLQVLNLTYC	CD180	441	Q99467
DLLYDILNCQVHSNF	ARMC12	221	Q5T9G4
VCYNFRSIQQQILEH	ANKRD19P	241	Q9H560
QAIFLNSNCFEHLIR	NBEAL1	346	Q6ZS30
HSIRNNFTYLCQIEL	OSMR	356	Q99650
LVSLCNFHNYDNLRH	GLS	521	O94925
YRSIIQRIQEFCNLH	NUBP1	296	P53384
RQAYESNLICHGLQL	ANO6	96	Q4KMQ2
QLFNHALRNALFCLE	OVOS1	896	Q6IE37
LRVLLENQITHFRYC	CADPS	786	Q9ULU8
LSNDHICYFLYQILR	MAPK1	121	P28482
IIVQLLSQHNYCLND	FIGN	661	Q5HY92
ELLNNRLHADVYTFN	PTCD3	281	Q96EY7
ACHFVSLENLNLYQN	LRCH3	101	Q96II8
CYRNLRHLQTITLDN	LRCH3	236	Q96II8
IFYVLHQRDNCQQLN	GPR82	271	Q96P67
ILFADLLCQYHRLDV	MDC1	121	Q14676
ERLLANQQVFHISCF	LIMA1	401	Q9UHB6
QLVDNVYCIGQRRFH	NCK2	336	O43639
LCAHRYLNQTIQDDA	MYO16	616	Q9Y6X6
ELFHLFRQQLYNLET	MMS22L	91	Q6ZRQ5
LDCYSHNQRSVLQLL	ARMC9	366	Q7Z3E5
QILRNRVDLQHLCGY	FAM91A1	641	Q658Y4
LAQRLACSFQHSYRL	ABAT	6	P80404
LQSQVENLLHRTYCR	MCM3AP	1706	O60318
FICEQDHQNFLRLLT	HSPH1	656	Q92598
AFNLFCSDLRSQIHL	IL17RB	426	Q9NRM6
NYVHSDLALRNCLLT	LMTK3	261	Q96Q04
LDFIQSHLRRFCLQY	DYNC1LI2	251	O43237
VLNFYKHNCLTRLDQ	DDX60L	1626	Q5H9U9
YNQCVQALAELRSYH	IDO2	346	Q6ZQW0
CHNYTQDRLQRLFHE	MYO18A	811	Q92614
LFDIEACHRYLNIAL	PDZD8	701	Q8NEN9
YSDRIQVLQNLVHCA	PDE4C	531	Q08493
LNDSALRDLINCHVY	CUL7	551	Q14999
FAIQLLSHLCIQYAL	INTS2	1056	Q9H0H0
HREILQALAALVYCN	HEATR6	136	Q6AI08
TYFQRAQSLHGQRCL	DSE	921	Q9UL01
ISQLENFCRYLVHLA	PAXBP1	846	Q9Y5B6
FQLRPACQQVYNLFH	PITPNM2	746	Q9BZ72
ALVQYINQLCRHLAI	HECTD4	3466	Q9Y4D8
LLCENYRSHEAIINY	HELZ	861	P42694
QLHCYNERLLDFTQA	NBAS	1631	A2RRP1
NHLYRFLRNIFVLTC	PIGU	346	Q9H490
LQAKILQCYRENTHQ	CHCHD3	186	Q9NX63
VQNLAQYIFLHQCIL	PTPRQ	2276	Q9UMZ3
QYIFLHQCILDLLSN	PTPRQ	2281	Q9UMZ3
VNQLHQRYIKELCNL	MOGAT2	301	Q3SYC2
IHNFNINYRIQCSVS	PRG2	136	P13727
LVSIHDFNFNYRIQC	PRG3	136	Q9Y2Y8
QLHLYCLNTFIQSRA	PGR	886	P06401
LHSQCVLREEAYFLL	FRMD6	141	Q96NE9
LIANTLCNSRQLYDH	HABP2	471	Q14520
DYRQVLRDHNCLQTL	APC2	616	O95996
LAYLQRIALYCHQLN	CTNNA2	776	P26232
GHVFQALQYLRKLCN	BTAF1	1566	O14981
QRYFQVLCSINSIIH	CEP70	346	Q8NHQ1
EYAHISRLQADLNCL	GCNT4	196	Q9P109
RLTINAECYLQLHNF	GABRG1	181	Q8N1C3
FLFQLLRGLAYCHRQ	CDK16	266	Q00536
VDHNYYAVCQNLLSR	DIPK2A	356	Q8NDZ4
SQFCLQRIHQGLIFY	IL23A	86	Q9NPF7
SQQVLQLCLRYQDHL	BORCS5	86	Q969J3
AHQVEQVLLAYSRCL	DDX12P	761	Q92771
HNLQNLSLAYCRRFT	FBXL13	296	Q8NEE6
NLNYLSLRNCEHLTA	FBXL13	506	Q8NEE6
NQLYLHRGTQELLEC	LYST	2381	Q99698
NRFLNHCLEHLVQYR	IL2RG	176	P31785
LQQELNRLYSLFCSR	DDHD1	506	Q8NEL9
VLNNSLLLHYINCVR	CENPI	366	Q92674
NEYHRRLNCNLTQIG	GRIK5	726	Q16478
LLHRLFLCYQQETHE	HELZ2	716	Q9BYK8
LQLELHCQVMFRNYQ	CHD4	561	Q14839
LQHSLQYHCLSAQLR	RUBCN	126	Q92622
LIAACYNNHQNKIIL	SCAPER	1321	Q9BY12
ALLYQIDSRLCIEHF	SLC39A10	366	Q9ULF5
HSCEENYRLILQLFV	SLC39A12	391	Q504Y0
TLSIFLCRNLDHVYN	CD37	261	P11049
VCNSGLLLYRELHNQ	ERCC6L	81	Q2NKX8
NISNDQLHALLCIYL	FANCD2	1176	Q9BXW9
EITNLRNLKCLYLQH	LRRC40	146	Q9H9A6
YLDFRNRLQADHVCL	PPP1R3B	121	Q86XI6
NLLAFCRRIEQHYFE	MTX2	241	O75431
SNLLYQEQHVFQLRA	FER1L6	816	Q2WGJ9
LCQGLNEEIRHYLFR	RTL1	326	A6NKG5
HNLICYADLIQERQL	RTTN	31	Q86VV8
CHLLTDVLQRYLQQL	TAF3	31	Q5VWG9
INLDVNRILGYRHFC	VARS1	936	P26640
RLDCFIHQVKNSLYN	SENP2	51	Q9HC62
IFYHIHRLCLARIQN	RNF133	206	Q8WVZ7
LHSLDLRANCYQRFV	TRMT1	296	Q9NXH9
CGYNNEHLLLNLKRD	TRIM36	521	Q9NQ86
ERVLAHFSQRYFQCN	PSD	626	A5PKW4
RSHLQAYLNLAQKCV	TMEM161B	331	Q8NDZ6
VFNASVQFLHCQLSR	TGFBR3L	161	H3BV60
HQCFQCQDTLSLYRL	NPHP3	736	Q7Z494
LLFCQDHYAQLKREN	HMGB4	101	Q8WW32
CNLLHSNSFIRNNYI	PLPP1	81	O14494
LLLCRSFQLAYLLQH	SH2D5	136	Q6ZV89
NTHENLTYLQLLERC	EPPK1	771	P58107
NTHENLTYVQLLRRC	EPPK1	2926	P58107
NTHENLTYVQLLRRC	EPPK1	3991	P58107
FQRLNFLYQAAHCVL	RPP21	11	Q9H633
QRCFAHYDVQSILFN	SIPA1L2	326	Q9P2F8
FFGLCNLQILYLNHN	RXFP2	181	Q8WXD0
DIQLQHGALCFNIRY	TENM1	2621	Q9UKZ4
CLNAYHARRNVFDLV	WHRN	61	Q9P202
FVRNHQYSLQILAHC	RASGRF1	336	Q13972
QYSLQILAHCKQNRD	RASGRF1	341	Q13972
ILGRYQDHLQQCLFQ	TRAF5	121	O00463
TNFNYRRACLVHNEL	TASOR	141	Q9UK61
FLIHCLLNGQVREEY	ADGRE1	841	Q14246
LLQQVRALHQHYSCR	ANKFN1	391	Q8N957
RQNLQLCVQVASKYH	CLTCL1	676	P53675
FHRQLLYLQFQKRCL	C10orf126	151	Q8N4M7
ECTQYQQILHRNLVY	SS18L1	46	O75177
LSVLLVQNRDHLYNF	TMEM270	21	Q6UE05
FFQLNYLQHLSLSRC	SKP2	331	Q13309
LFRSQHYALLDNSCR	VPS52	381	Q8N1B4
FQQLNYQRLHGQLCD	ZBTB5	11	O15062
VTQLRYESFCLHQFQ	ZSCAN31	161	Q96LW9
DHLFCQYLFRNALEI	UGT1A10	216	Q9HAW8
NQTECFNHVRFLQRL	SEMA4G	111	Q9NTN9
HRFLYDQDLACTVLQ	SERPINA11	251	Q86U17
LNCIDRLNVYNSVAH	RYR3	486	Q15413
RQADCHINNLYNTVF	THG1L	176	Q9NWX6
SHLQLRIYFLNNTPC	UNC5CL	261	Q8IV45
CRVQYNNLEQHLFSA	ZDBF2	11	Q9HCK1
HFYLVQLLQDVLCRS	WWOX	236	Q9NZC7
AYCLHQRRVALAELQ	ACP6	21	Q9NPH0
VLFYTFQRNLRCHDV	PREPL	216	Q4J6C6
SVYNANINLFCVLRL	PKD2L1	306	Q9P0L9
YAHRLSQDILCDALQ	C2orf88	61	Q9BSF0
CRHIQCFDLESYLQL	ZMIZ2	616	Q8NF64
CTRNYIHLNLFLSFI	VIPR2	156	P41587
CIYRILRLHENADFQ	TNFSF11	86	O14788
FLIQHENRYRQCIAA	PLEKHG7	631	Q6ZR37
ENRYRQCIAAFLLQA	PLEKHG7	636	Q6ZR37
AYSLQQDNCKHLERL	TTC16	121	Q8NEE8
HLERLTFVLYLQGQC	TTC16	131	Q8NEE8
AQRQLLLTYNDFAVH	TTC16	326	Q8NEE8
IYHFNSELLQDLENC	PLEKHG1	166	Q9ULL1
FSLCRYNNRLAEHIV	USP34	2571	Q70CQ2
LQRDRCLYHNTKLDN	WDR26	311	Q9H7D7
LNVLEYLALQCSHFL	UGT3A2	111	Q3SY77
FHEYLLLVFQLVQAC	RPTN	71	Q6XPR3
HGCIRNLYINNELQD	SLIT1	1311	O75093
EHLQYLFALLQNSNR	USP48	146	Q86UV5
EAQYVFLHQCILRFL	PTPRH	1066	Q9HD43
YCLSNNKHFLEQILV	ZFYVE26	326	Q68DK2
NCVCILHNLSYQLEA	PKP2	606	Q99959
NLALSSRCLQLIVHY	VPS54	806	Q9P1Q0
ELLNLCSHYLIQELN	KLHL32	126	Q96NJ5
HFVANCTLQFQELLR	PRKCH	96	P24723
IFNEALVCHQIRYLG	MYO1B	606	O43795