Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyBiologicalProcess	cellular response to abiotic stimulus	BARD1 NLRP1 SAG MTOR AKT2 PLEC NFAT5 ENG NIPBL KDM1A	1.29e-05	371	100	10	GO:0071214
GeneOntologyBiologicalProcess	cellular response to environmental stimulus	BARD1 NLRP1 SAG MTOR AKT2 PLEC NFAT5 ENG NIPBL KDM1A	1.29e-05	371	100	10	GO:0104004
GeneOntologyBiologicalProcess	regulation of action potential firing rate	TRPC4 KCNC2	2.33e-05	2	100	2	GO:0099605
GeneOntologyBiologicalProcess	response to abiotic stimulus	FOXP2 CKAP5 BARD1 IRAK1 NLRP1 PDZD7 RDH13 SAG KCNC2 MTOR ALDH18A1 AKT2 STRC PLEC NFAT5 ENG NIPBL KDM1A STRCP1	2.55e-05	1361	100	19	GO:0009628
GeneOntologyBiologicalProcess	response to light intensity	RDH13 KCNC2 AKT2	7.16e-05	17	100	3	GO:0009642
GeneOntologyCellularComponent	stereocilium tip	EPS8 PDZD7 STRC STRCP1	3.51e-06	22	101	4	GO:0032426
Domain	HEAT	CKAP5 MTOR NIPBL IPO11	1.91e-04	58	92	4	IPR000357
Domain	AWS	ASH1L NSD1	2.38e-04	5	92	2	SM00570
Domain	AWS	ASH1L NSD1	2.38e-04	5	92	2	PS51215
Domain	AWS_dom	ASH1L NSD1	2.38e-04	5	92	2	IPR006560
Domain	ARM-type_fold	INTS1 CKAP5 HUWE1 MTOR XPO6 PKP2 NIPBL IPO11	2.69e-04	339	92	8	IPR016024
Domain	TRP_dom	TRPC4 TRPC5	3.55e-04	6	92	2	IPR013555
Domain	TRP_2	TRPC4 TRPC5	3.55e-04	6	92	2	PF08344
Domain	ARM-like	CKAP5 HUWE1 MTOR XPO6 PKP2 NIPBL IPO11	3.76e-04	270	92	7	IPR011989
Domain	HEAT_REPEAT	CKAP5 MTOR NIPBL IPO11	3.94e-04	70	92	4	PS50077
Domain	PH_DOMAIN	EPS8 ARHGEF28 CDC42BPB TIAM2 CMIP AKT2 RASAL1	4.57e-04	279	92	7	PS50003
Domain	PH_domain	EPS8 ARHGEF28 CDC42BPB TIAM2 CMIP AKT2 RASAL1	4.67e-04	280	92	7	IPR001849
Domain	TRPC_channel	TRPC4 TRPC5	4.96e-04	7	92	2	IPR002153
Domain	UBA	DHX57 HUWE1 UBAC2	7.34e-04	36	92	3	PF00627
Domain	-	CKAP5 MTOR XPO6 PKP2 NIPBL IPO11	8.03e-04	222	92	6	1.25.10.10
Domain	PDZ	PCLO PDZD7 TIAM2 PTPN13 CARD11	9.03e-04	151	92	5	PS50106
Domain	PDZ	PCLO PDZD7 TIAM2 PTPN13 CARD11	9.31e-04	152	92	5	IPR001478
Domain	PH_dom-like	EPS8 ARHGEF28 CDC42BPB TIAM2 PTPN13 CMIP AKT2 RASAL1	1.20e-03	426	92	8	IPR011993
Domain	TRP_channel	TRPC4 TRPC5	1.28e-03	11	92	2	IPR004729
Domain	UBA	DHX57 HUWE1 UBAC2	1.32e-03	44	92	3	IPR015940
Domain	UBA	DHX57 HUWE1 UBAC2	1.60e-03	47	92	3	PS50030
Domain	IMPORTIN_B_NT	XPO6 IPO11	2.10e-03	14	92	2	PS50166
Domain	ADH_SHORT	RDH14 RDH13 DHRS7C	2.27e-03	53	92	3	PS00061
Domain	IBN_N	XPO6 IPO11	2.42e-03	15	92	2	PF03810
Domain	adh_short	RDH14 RDH13 DHRS7C	2.52e-03	55	92	3	PF00106
Domain	PH	ARHGEF28 CDC42BPB TIAM2 CMIP AKT2 RASAL1	2.52e-03	278	92	6	SM00233
Domain	SDR_fam	RDH14 RDH13 DHRS7C	2.65e-03	56	92	3	IPR002347
Domain	Post-SET_dom	ASH1L NSD1	2.75e-03	16	92	2	IPR003616
Domain	PostSET	ASH1L NSD1	2.75e-03	16	92	2	SM00508
Domain	IBN_N	XPO6 IPO11	2.75e-03	16	92	2	SM00913
Domain	POST_SET	ASH1L NSD1	2.75e-03	16	92	2	PS50868
Domain	Importin-beta_N	XPO6 IPO11	3.11e-03	17	92	2	IPR001494
Domain	-	EPS8 ARHGEF28 CDC42BPB TIAM2 PTPN13 AKT2 RASAL1	3.18e-03	391	92	7	2.30.29.30
Domain	UBA-like	DHX57 HUWE1 UBAC2	3.88e-03	64	92	3	IPR009060
Pubmed	Clarin-2 is essential for hearing by maintaining stereocilia integrity and function.	EPS8 PDZD7 STRC STRCP1	2.26e-08	11	102	4	31448880
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	PCNX3 INTS1 HECTD4 NSD1 IRAK1 TBC1D25 HUWE1 CDC42BPB TIAM2 C2CD3 TKFC MTOR XPO6 ZFYVE26 AKT2 PLEC RASAL1	2.29e-08	1105	102	17	35748872
Pubmed	Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription.	INTS1 CKAP5 NSD1 DHX57 HUWE1 MTOR SYNE2 ALDH18A1 RRP7A PLEC NIPBL KDM1A	5.04e-07	653	102	12	22586326
Pubmed	The RNA-mediated estrogen receptor α interactome of hormone-dependent human breast cancer cell nuclei.	EPS8 RNF169 PCNX3 INTS1 CKAP5 NSD1 DHX57 RDH13 CDC42BPB SLC3A2 SHKBP1 PTPN13 ALDH18A1 RRP7A NIPBL KDM1A	7.37e-06	1497	102	16	31527615
Pubmed	CBB1003, a lysine-specific demethylase 1 inhibitor, suppresses colorectal cancer cells growth through down-regulation of leucine-rich repeat-containing G-protein-coupled receptor 5 expression.	LGR5 KDM1A	8.52e-06	2	102	2	25060070
Pubmed	LSD1 negatively regulates autophagy through the mTOR signaling pathway in ovarian cancer cells.	MTOR KDM1A	8.52e-06	2	102	2	29749504
Pubmed	Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.	STRC STRCP1	8.52e-06	2	102	2	34910522
Pubmed	Akt2, but not Akt1 or Akt3 mediates pressure-stimulated serum-opsonized latex bead phagocytosis through activating mTOR and p70 S6 kinase.	MTOR AKT2	8.52e-06	2	102	2	17372934
Pubmed	Selective Gαi subunits as novel direct activators of transient receptor potential canonical (TRPC)4 and TRPC5 channels.	TRPC4 TRPC5	8.52e-06	2	102	2	22457348
Pubmed	Conserved gating elements in TRPC4 and TRPC5 channels.	TRPC4 TRPC5	8.52e-06	2	102	2	23677990
Pubmed	Involvement of TRPC4 and 5 Channels in Persistent Firing in Hippocampal CA1 Pyramidal Cells.	TRPC4 TRPC5	8.52e-06	2	102	2	32033274
Pubmed	The first ankyrin-like repeat is the minimum indispensable key structure for functional assembly of homo- and heteromeric TRPC4/TRPC5 channels.	TRPC4 TRPC5	8.52e-06	2	102	2	17624425
Pubmed	Downregulation of TRPC4 and TRPC5 Inhibits Smooth Muscle Cell Proliferation without Affecting Endothelial Cell Proliferation.	TRPC4 TRPC5	8.52e-06	2	102	2	34899056
Pubmed	Corticolimbic expression of TRPC4 and TRPC5 channels in the rodent brain.	TRPC4 TRPC5	8.52e-06	2	102	2	17593972
Pubmed	KDM1A inhibition augments the efficacy of rapamycin for the treatment of endometrial cancer.	MTOR KDM1A	8.52e-06	2	102	2	34673129
Pubmed	Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.	STRC STRCP1	8.52e-06	2	102	2	11687802
Pubmed	Acute Treatment with a Novel TRPC4/C5 Channel Inhibitor Produces Antidepressant and Anxiolytic-Like Effects in Mice.	TRPC4 TRPC5	8.52e-06	2	102	2	26317356
Pubmed	NFAT5 Deficiency Alleviates Formalin-Induced Inflammatory Pain Through mTOR.	MTOR NFAT5	8.52e-06	2	102	2	33806698
Pubmed	A novel capacitative calcium entry channel expressed in excitable cells.	TRPC4 TRPC5	8.52e-06	2	102	2	9687496
Pubmed	Gene Body Methylation of the Lymphocyte-Specific Gene CARD11 Results in Its Overexpression and Regulates Cancer mTOR Signaling.	MTOR CARD11	8.52e-06	2	102	2	34348992
Pubmed	mTOR inhibition prevents rapid-onset of carcinogen-induced malignancies in a novel inducible HPV-16 E6/E7 mouse model.	LGR5 MTOR	8.52e-06	2	102	2	27538837
Pubmed	TRPC4/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (-)-Englerin A.	TRPC4 TRPC5	8.52e-06	2	102	2	30038709
Pubmed	Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder.	ASH1L DHX57 CDC42BPB	8.71e-06	14	102	3	28263302
Pubmed	Corrected centromere orientation for mouse chromosome 19 MIT markers.	BLNK IDE SLC3A2	1.33e-05	16	102	3	8499657
Pubmed	A linkage map of mouse chromosome 19: definition of comparative mapping relationships with human chromosomes 10 and 11 including the MEN1 locus.	BLNK IDE SLC3A2	1.94e-05	18	102	3	1358795
Pubmed	Reduction of Nipbl impairs cohesin loading locally and affects transcription but not cohesion-dependent functions in a mouse model of Cornelia de Lange Syndrome.	PCDH11Y PCDHB18P NIPBL	2.29e-05	19	102	3	23920377
Pubmed	Identification and functional characterization of transcriptional activators in human cells.	PCLO E2F7 IRAK1 NLRP1 IDE ZNF518A SYNE2 EPC1	2.36e-05	398	102	8	35016035
Pubmed	Heteromeric channels formed by TRPC1, TRPC4 and TRPC5 define hippocampal synaptic transmission and working memory.	TRPC4 TRPC5	2.55e-05	3	102	2	28790178
Pubmed	Cochlear outer hair cell horizontal top connectors mediate mature stereocilia bundle mechanics.	STRC STRCP1	2.55e-05	3	102	2	30801007
Pubmed	DDiT4L promotes autophagy and inhibits pathological cardiac hypertrophy in response to stress.	DDIT4L MTOR	2.55e-05	3	102	2	28246202
Pubmed	Differential PI(4,5)P2 sensitivities of TRPC4, C5 homomeric and TRPC1/4, C1/5 heteromeric channels.	TRPC4 TRPC5	2.55e-05	3	102	2	30755645
Pubmed	Genetic association study of NLRP1, CARD, and CASP1 inflammasome genes with chronic Chagas cardiomyopathy among Trypanosoma cruzi seropositive patients in Bolivia.	NLRP1 CARD11	2.55e-05	3	102	2	29438387
Pubmed	Akt and mTOR mediate programmed necrosis in neurons.	MTOR AKT2	2.55e-05	3	102	2	24577082
Pubmed	The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway.	DDIT4L MTOR	2.55e-05	3	102	2	15632201
Pubmed	Farnesoid X receptor-induced lysine-specific histone demethylase reduces hepatic bile acid levels and protects the liver against bile acid toxicity.	NR0B2 KDM1A	2.55e-05	3	102	2	25545350
Pubmed	Transient Receptor Potential C 1/4/5 Is a Determinant of MTI-101 Induced Calcium Influx and Cell Death in Multiple Myeloma.	TRPC4 TRPC5	2.55e-05	3	102	2	34199280
Pubmed	The EGFR-mTOR pathway and laryngeal cancer angiogenesis.	MTOR ENG	2.55e-05	3	102	2	24065188
Pubmed	Sphingosine kinase 1 expression is regulated by signaling through PI3K, AKT2, and mTOR in human coronary artery smooth muscle cells.	MTOR AKT2	2.55e-05	3	102	2	17482291
Pubmed	Leishmania-induced IRAK-1 inactivation is mediated by SHP-1 interacting with an evolutionarily conserved KTIM motif.	IRAK1 NR0B2	2.55e-05	3	102	2	19104650
Pubmed	Regulatory effects of mammalian target of rapamycin-mediated signals in the generation of arsenic trioxide responses.	MTOR AKT2	2.55e-05	3	102	2	18048359
Pubmed	TRPC1/4/5 channels contribute to morphine-induced analgesic tolerance and hyperalgesia by enhancing spinal synaptic potentiation and structural plasticity.	TRPC4 TRPC5	2.55e-05	3	102	2	32359120
Pubmed	Differential healing after sirolimus, paclitaxel, and bare metal stent placement in combination with peroxisome proliferator-activator receptor gamma agonists: requirement for mTOR/Akt2 in PPARgamma activation.	MTOR AKT2	2.55e-05	3	102	2	19797172
Pubmed	Deficiency of Akt1, but not Akt2, attenuates the development of pulmonary hypertension.	MTOR AKT2	2.55e-05	3	102	2	25416384
Pubmed	Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels.	TRPC4 TRPC5	2.55e-05	3	102	2	28325835
Pubmed	Cross-linking CD98 promotes integrin-like signaling and anchorage-independent growth.	SLC3A2 AKT2	2.55e-05	3	102	2	12181350
Pubmed	Rab4A-directed endosome traffic shapes pro-inflammatory mitochondrial metabolism in T cells via mitophagy, CD98 expression, and kynurenine-sensitive mTOR activation.	SLC3A2 MTOR	2.55e-05	3	102	2	38519468
Pubmed	Dual action of the Gαq-PLCβ-PI(4,5)P2 pathway on TRPC1/4 and TRPC1/5 heterotetramers.	TRPC4 TRPC5	2.55e-05	3	102	2	30108272
Pubmed	Spatiotemporal profile of postsynaptic interactomes integrates components of complex brain disorders.	FOXP2 TRPC4 HECTD4 CKAP5 NSD1 HUWE1 CDC42BPB MTOR SYNE2 NIPBL KDM1A RASAL1	2.61e-05	963	102	12	28671696
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	CKAP5 DHX57 CDC42BPB TMEM33 MTOR PLEC	3.02e-05	202	102	6	33005030
Pubmed	A central chaperone-like role for 14-3-3 proteins in human cells.	ARHGEF28 TTC28 CKAP5 SHKBP1 FSIP2 C2CD3 PTPN13 MTOR SYNE2 PKP2 PLEC	4.62e-05	861	102	11	36931259
Pubmed	Interaction with dopamine D2 receptor enhances expression of transient receptor potential channel 1 at the cell surface.	TRPC4 TRPC5	5.09e-05	4	102	2	18261457
Pubmed	A phosphatidylinositol 3-kinase/protein kinase B-independent activation of mammalian target of rapamycin signaling is sufficient to induce skeletal muscle hypertrophy.	MTOR AKT2	5.09e-05	4	102	2	20668162
Pubmed	Stereocilin-deficient mice reveal the origin of cochlear waveform distortions.	STRC STRCP1	5.09e-05	4	102	2	18849963
Pubmed	The phospholipid-binding protein SESTD1 is a novel regulator of the transient receptor potential channels TRPC4 and TRPC5.	TRPC4 TRPC5	5.09e-05	4	102	2	20164195
Pubmed	mTOR-Independent autophagy inducer trehalose rescues against insulin resistance-induced myocardial contractile anomalies: Role of p38 MAPK and Foxo1.	MTOR AKT2	5.09e-05	4	102	2	27363949
Pubmed	T cell receptor-dependent activation of mTOR signaling in T cells is mediated by Carma1 and MALT1, but not Bcl10.	MTOR CARD11	5.09e-05	4	102	2	24917592
Pubmed	Feedbacks and adaptive capabilities of the PI3K/Akt/mTOR axis in acute myeloid leukemia revealed by pathway selective inhibition and phosphoproteome analysis.	MTOR AKT2	5.09e-05	4	102	2	24699302
Pubmed	mTOR disruption causes intestinal epithelial cell defects and intestinal atrophy postinjury in mice.	LGR5 MTOR	5.09e-05	4	102	2	26631481
Pubmed	NMDA receptor-dependent synaptic activation of TRPC channels in olfactory bulb granule cells.	TRPC4 TRPC5	5.09e-05	4	102	2	22539836
Pubmed	LSD1 represses a neonatal/reparative gene program in adult intestinal epithelium.	LGR5 KDM1A	5.09e-05	4	102	2	32917713
Pubmed	mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes.	MTOR AKT2	5.09e-05	4	102	2	16221682
Pubmed	STEF/TIAM2-mediated Rac1 activity at the nuclear envelope regulates the perinuclear actin cap.	TIAM2 SYNE2	5.09e-05	4	102	2	29844364
Pubmed	Transient Receptor Potential Canonical 5-Scramblase Signaling Complex Mediates Neuronal Phosphatidylserine Externalization and Apoptosis.	TRPC4 TRPC5	5.09e-05	4	102	2	32110987
Pubmed	TRPC5-induced autophagy promotes drug resistance in breast carcinoma via CaMKKβ/AMPKα/mTOR pathway.	TRPC5 MTOR	5.09e-05	4	102	2	28600513
Pubmed	HUWE1 is a molecular link controlling RAF-1 activity supported by the Shoc2 scaffold.	HUWE1 SHOC2	5.09e-05	4	102	2	25022756
Pubmed	Canonical transient receptor channel 5 (TRPC5) and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms.	TRPC4 TRPC5	5.09e-05	4	102	2	23188715
Pubmed	Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.	EPS8 TTC28 SHKBP1 PTPN13 PKP2 ALDH18A1 CEP295 IPO11	5.26e-05	446	102	8	24255178
Pubmed	Phenotypic and Interaction Profiling of the Human Phosphatases Identifies Diverse Mitotic Regulators.	RNF169 IDE HUWE1 SHOC2 CDC42BPB SLC3A2 SHKBP1 C2CD3 PTPN13 PRIM2 SYNE2 ALDH18A1	5.95e-05	1049	102	12	27880917
Pubmed	Systems analysis of RhoGEF and RhoGAP regulatory proteins reveals spatially organized RAC1 signalling from integrin adhesions.	RNF169 ARHGEF28 TAGAP HUWE1 TIAM2 SLC3A2 TMEM33 PKP2 ALDH18A1 PLEC KDM1A	8.02e-05	916	102	11	32203420
Pubmed	Human Immunodeficiency Virus Type 1 Vpr Mediates Degradation of APC1, a Scaffolding Component of the Anaphase-Promoting Complex/Cyclosome.	INTS1 NSD1 IRAK1 XPO6 EPC1 AKT2	8.23e-05	242	102	6	34011540
Pubmed	Formation of novel TRPC channels by complex subunit interactions in embryonic brain.	TRPC4 TRPC5	8.47e-05	5	102	2	12857742
Pubmed	Enhanced capacitative calcium entry and TRPC channel gene expression in human LES smooth muscle.	TRPC4 TRPC5	8.47e-05	5	102	2	12736151
Pubmed	Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradiotherapy.	MTOR AKT2	8.47e-05	5	102	2	19164214
Pubmed	Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF.	TRPC4 TRPC5	8.47e-05	5	102	2	10980202
Pubmed	TRUSS, TNF-R1, and TRPC ion channels synergistically reverse endoplasmic reticulum Ca2+ storage reduction in response to m1 muscarinic acetylcholine receptor signaling.	TRPC4 TRPC5	8.47e-05	5	102	2	20458742
Pubmed	PI3K/PTEN/AKT/mTOR pathway genetic variation predicts toxicity and distant progression in lung cancer patients receiving platinum-based chemotherapy.	MTOR AKT2	8.47e-05	5	102	2	20447721
Pubmed	A postprandial FGF19-SHP-LSD1 regulatory axis mediates epigenetic repression of hepatic autophagy.	NR0B2 KDM1A	8.47e-05	5	102	2	28446510
Pubmed	Systematic perturbations of SETD2, NSD1, NSD2, NSD3, and ASH1L reveal their distinct contributions to H3K36 methylation.	ASH1L NSD1	8.47e-05	5	102	2	39390582
Pubmed	The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model.	SHOC2 SAG	8.47e-05	5	102	2	36543126
Pubmed	An unusually powerful mode of low-frequency sound interference due to defective hair bundles of the auditory outer hair cells.	STRC STRCP1	8.47e-05	5	102	2	24920589
Pubmed	The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradation.	DHX57 HUWE1 SLC3A2 PKP2 RRP7A KDM1A	1.05e-04	253	102	6	29911972
Pubmed	The Hsp70-Hsp90 co-chaperone Hop/Stip1 shifts the proteostatic balance from folding towards degradation.	CKAP5 IRAK1 HUWE1 SLC3A2 MTOR PRIM2 PLEC KDM1A IPO11	1.12e-04	638	102	9	33239621
Pubmed	TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.	TTC28 BARD1 TBC1D25 IDE SLC3A2 SYNE2 RRP7A CEP295 NIPBL	1.12e-04	638	102	9	31182584
Pubmed	Interpreting cancer genomes using systematic host network perturbations by tumour virus proteins.	ABCC4 PCLO RDH14 SLC3A2 TMEM33 UBAC2 ENG UTP14C	1.15e-04	499	102	8	22810586
Pubmed	Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing.	ABCC4 PCDH11Y ASH1L HECTD4 BLNK BARD1 IDE HUWE1 CDC42BPB SHKBP1 PTPN13 CMIP TMEM98 NFAT5	1.15e-04	1489	102	14	28611215
Pubmed	The FBXW7-SHOC2-Raptor Axis Controls the Cross-Talks between the RAS-ERK and mTORC1 Signaling Pathways.	SHOC2 MTOR	1.27e-04	6	102	2	30865892
Pubmed	Calcium Channels Formed by Mammalian Trp Homologues.	TRPC4 TRPC5	1.27e-04	6	102	2	11390792
Pubmed	trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry.	TRPC4 TRPC5	1.27e-04	6	102	2	8646775
Pubmed	TRPC channels regulate Ca2+-signaling and short-term plasticity of fast glutamatergic synapses.	TRPC4 TRPC5	1.27e-04	6	102	2	31536487
Pubmed	HUWE1 is a critical colonic tumour suppressor gene that prevents MYC signalling, DNA damage accumulation and tumour initiation.	HUWE1 LGR5	1.27e-04	6	102	2	28003334
Pubmed	TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations.	TRPC4 TRPC5	1.27e-04	6	102	2	32414784
Pubmed	TorsinA binds the KASH domain of nesprins and participates in linkage between nuclear envelope and cytoskeleton.	SYNE2 PLEC	1.27e-04	6	102	2	18827015
Pubmed	Histone H2A ubiquitination inhibits the enzymatic activity of H3 lysine 36 methyltransferases.	ASH1L NSD1	1.27e-04	6	102	2	24019522
Pubmed	The role of USP7 in the Shoc2-ERK1/2 signaling axis and Noonan-like syndrome with loose anagen hair.	HUWE1 SHOC2	1.27e-04	6	102	2	34553755
Pubmed	mTOR signaling regulates gastric epithelial progenitor homeostasis and gastric tumorigenesis via MEK1-ERKs and BMP-Smad1 pathways.	LGR5 MTOR	1.27e-04	6	102	2	33951440
Pubmed	TRPC proteins contribute to development of diabetic retinopathy and regulate glyoxalase 1 activity and methylglyoxal accumulation.	TRPC4 TRPC5	1.27e-04	6	102	2	29373286
Pubmed	Transient receptor potential channels and their role in modulating radial glial-neuronal interaction: a signaling pathway involving mGluR5.	TRPC4 TRPC5	1.27e-04	6	102	2	25347706
Pubmed	Hypothalamic warm-sensitive neurons require TRPC4 channel for detecting internal warmth and regulating body temperature in mice.	TRPC4 TRPC5	1.27e-04	6	102	2	36476978
Pubmed	Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.	PCLO HUWE1 XPO6 SYNE2	1.29e-04	87	102	4	12465718
Pubmed	Sequential genome-wide CRISPR-Cas9 screens identify genes regulating cell-surface expression of tetraspanins.	POMT2 TAGAP NSD1 ATP10B IDE CMIP IL1RAPL2 MTOR ZFYVE26 NFAT5	1.71e-04	832	102	10	36724073
GeneFamily	PDZ domain containing	PCLO PDZD7 TIAM2 PTPN13 CARD11	2.33e-04	152	66	5	1220
GeneFamily	Short chain dehydrogenase/reductase superfamily	RDH14 RDH13 DHRS7C	2.70e-03	76	66	3	743
GeneFamily	T cell receptor gamma locus at 7p14	TRGV3 TRGV5	2.89e-03	22	66	2	375
GeneFamily	PWWP domain containing	NSD1 PWWP3B	2.89e-03	22	66	2	1147
CoexpressionAtlas	FacebaseRNAseq_e10.5_Neural Epithelium Flanking Eminence_top-relative-expression-ranked_500_k-means-cluster#3	CKAP5 KIAA1549L IGFBP7 SYNE2 CEP295 NIPBL IPO11	2.33e-05	192	94	7	Facebase_RNAseq_e10.5_Neural Epithelium Flanking Eminence_500_K3
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L6_IT-L6_IT_VISp_Col23a1_Adamts2\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	BLNK NTNG1 BPIFB1 TIAM2 IL1RAPL2 RASAL1	2.48e-06	168	102	6	3fe432267656aff81b6d92c18d1b6fc0cde73d6a
ToppCell	facs-Heart-RA-18m-Endothelial-endothelial_cell_of_endocardium\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPS8 KIAA1549L KCNC2 IL1RAPL2 ENG IPO11	2.48e-06	168	102	6	06dc5b2d356d3a9454b10bba6f3b9ead2a0a7d46
ToppCell	facs-Heart-RA-18m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPS8 KIAA1549L KCNC2 IL1RAPL2 ENG IPO11	2.48e-06	168	102	6	1002f058a340763e3d8de0bd1f0547a903526ec6
ToppCell	pdx-Tumor_cells-T0\|Tumor_cells / Sample and Cell Type and Tumor Cluster (all cells)	ADGRG5 ARHGEF28 HECTD4 LGR5 CMIP NFAT5	4.33e-06	185	102	6	1d874608aa2062024323512f68889219471b2f00
ToppCell	pdx\|World / Sample and Cell Type and Tumor Cluster (all cells)	TTC28 HECTD4 LGR5 CMIP PRIM2 NFAT5	4.46e-06	186	102	6	de8e538c8767d41b8a52f5e58ba1affd4e7244c4
ToppCell	pdx-Tumor_cells\|World / Sample and Cell Type and Tumor Cluster (all cells)	TTC28 HECTD4 LGR5 CMIP PRIM2 NFAT5	4.46e-06	186	102	6	0b88a87158a9ca8de3bf40a4ff1687150707a5f0
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2-D175\|Adult / Lineage, Cell type, age group and donor	EPS8 ABCC4 TTC28 FOXP2 PCLO PTPN13	4.74e-06	188	102	6	ec38def1fdbb34ed9b30244806975bd5a4370164
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FOXP2 DDIT4L IGFBP7 SYNE2 AKT2 NFAT5	5.51e-06	193	102	6	0f2167eef8203a5659c8c72e4e77646003d64797
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	ARHGEF28 FOXP2 BLNK PTPN13 IL1RAPL2 RASAL1	6.02e-06	196	102	6	c7136b1c83bcf907eec3b02b151fa061298b6672
ToppCell	LPS_IL1RA_TNF-Endothelial-Endothelial-Vein\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	EPS8 CMIP KIAA1549L IGFBP7 SYNE2 PLEC	6.76e-06	200	102	6	7eb366b2c5394af7c77650bde6261e7dac67154e
ToppCell	Tracheal\|World / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGEF28 FOXP2 BPIFB1 PKP2 ALDH18A1 RASAL1	6.76e-06	200	102	6	682960e28542a3d6c119047cd0131941932cfdea
ToppCell	primary_visual_cortex-Neuronal-glutamatergic_neuron-L5_PT-L5_PT_VISp_Krt80\|primary_visual_cortex / Per Region, Lineage, Cell class, Cell type, Cell subtype	TRPC4 TRPC5 BLNK NTNG1 TIAM2	1.84e-05	141	102	5	40ef6d792e11fe10963d64eb0b606b90556c1a70
ToppCell	lymphoid-B_cell-pro-B\|World / Lineage, cell class and subclass	PCLO BLNK DDIT4L IGFBP7 FAM167A	3.47e-05	161	102	5	23138e579f07d5a6f20d41457cb573b4ac95a4ef
ToppCell	LPS-IL1RA+antiTNF-Lymphocytic_B-B_cells-B-cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TAGAP BLNK NLRP1 SAG CARD11	4.25e-05	168	102	5	eeb381b62c7ba263af96de1194ed59e57b6ca3ae
ToppCell	LPS-IL1RA+antiTNF-Lymphocytic_B-B_cells\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TAGAP BLNK NLRP1 SAG CARD11	4.25e-05	168	102	5	063d0368d656962b335154c230bdcd9236e7c9ad
ToppCell	LPS-IL1RA+antiTNF-Lymphocytic_B\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	TAGAP BLNK NLRP1 SAG CARD11	4.25e-05	168	102	5	a7c4251d8a83bc30196a444028a35c17c24dc291
ToppCell	Adult-Epithelial-alveolar_epithelial_cell_type_2/Club-like_(AT2/Club-like)-D231\|Adult / Lineage, Cell type, age group and donor	EPS8 ABCC4 PTPN13 SYNE2 PWWP3B	4.50e-05	170	102	5	269dee5abca9f6aa079f116f0d8f1d198604d9d4
ToppCell	primary_auditory_cortex_(A1C)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_2-Exc_L3-5_RORB_CMAHP\|primary_auditory_cortex_(A1C) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FOXP2 PCDH11Y BARD1 NTNG1 IL1RAPL2	4.50e-05	170	102	5	49fc45d8a5c3ad89d1649fa46d7a285891379392
ToppCell	390C-Lymphocytic-CD4_T-cell-CD4+_Effector_T_cell-2\|CD4_T-cell / Donor, Lineage, Cell class and subclass (all cells)	POMT2 ABCC4 DDIT4L TIAM2 PRIM2	4.89e-05	173	102	5	b9dee61973559e8c2fef3f2dafd43475b386befb
ToppCell	mild_COVID-19_(asymptomatic)-gd_T\|World / disease group, cell group and cell class (v2)	TRGV3 TRGV5 ANKRD30B TMEM89 SYNE2	4.89e-05	173	102	5	b6615ff02f5017d7150b1e33b53f8c7a26081a0d
ToppCell	facs-Lung-Endomucin-24m-Myeloid-Myeloid_Dendritic_Type_1\|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ADGRG5 TAGAP E2F7 UBE3D ZFYVE26	5.02e-05	174	102	5	7565f6d1c743809807d248ab0e098a2474d9c5b9
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Immune-Myeloid-Macrophage_Dendritic-Plasmacytoid_Dendritic_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	ADGRG5 TAGAP BLNK ZFYVE26 CARD11	5.30e-05	176	102	5	8488997e0f02e874f53fae1690da63e0dd1d0780
ToppCell	LPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	ABCC4 ARHGEF28 FOXP2 PTPN13 SYNE2	5.75e-05	179	102	5	fd2cbee532e7b44113410dca82aec7db1a7fb69f
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	EPS8 ABCC4 ARHGEF28 FOXP2 PTPN13	6.22e-05	182	102	5	17ed11a7ea366dd3106400511d5e628d3f1a9c3e
ToppCell	Somatosensory_Cortex_(S1)-Neuronal-Glutamatergic_Excit-Glut_C-D_(RORB)-Glut_D_(IT_RORB_THEMIS_LINC00507)_5\|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types	FOXP2 PCLO BARD1 NTNG1 IL1RAPL2	6.38e-05	183	102	5	274076a0978bce2bd53a1732045f18ef0f2d9985
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-AT2_Progenitor\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	EPS8 ABCC4 ARHGEF28 FOXP2 PTPN13	6.55e-05	184	102	5	d0c212a8fbaad24597a84018442b25c61c17ea58
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell-Cortical_Collecting_Duct_Intercalated_Cell_Type_A\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	EPS8 ABCC4 ARHGEF28 ALPK3 NFAT5	6.89e-05	186	102	5	a6ef5d5944af5689b5f27bef89cd05645eedbe50
ToppCell	LPS-IL1RA+antiTNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-IL1RA+antiTNF / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	EPS8 ABCC4 ARHGEF28 FOXP2 PTPN13	6.89e-05	186	102	5	e83718fabb057100835d3357df407f283d23fe16
ToppCell	COVID-19-Heart-EC_2\|Heart / Disease (COVID-19 only), tissue and cell type	ABCC4 ARHGEF28 CMIP SYNE2 ENG	7.07e-05	187	102	5	40ffc06a3e3251d9b12da390210d3e045af7537a
ToppCell	kidney_cells-Hypertensive_with+without-CKD-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FOXP2 DDIT4L IGFBP7 SYNE2 AKT2	7.07e-05	187	102	5	9225caf66e06ebe57e90d677122acb6498607f36
ToppCell	10x5'-GI_small-bowel-Lymphocytic_T_CD4-T_CD4/CD8\|GI_small-bowel / Manually curated celltypes from each tissue	ASH1L HUWE1 SYNE2 NFAT5 NIPBL	7.25e-05	188	102	5	ab9b725d6e0cdab8e9ddda6dee09e14730e9a578
ToppCell	LPS-IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	EPS8 ABCC4 ARHGEF28 FOXP2 PTPN13	7.25e-05	188	102	5	4bdf8d49af0e9da349b16e3f012e1b0eec04cc4f
ToppCell	renal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_intercalated_cell\|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group	EPS8 ABCC4 ARHGEF28 ALPK3 NFAT5	7.25e-05	188	102	5	e751cff2ac8fbc1487766c1871fcc5d1005286b0
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	BLNK PTPN13 IL1RAPL2 NFAT5 RASAL1	7.25e-05	188	102	5	e30a4ddac0da8cdcf621d98e28e3895cd9307e7a
ToppCell	renal_medulla_nuclei-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC4 FOXP2 DDIT4L SYNE2 NFAT5	7.43e-05	189	102	5	904b8337e2cabac2f0bf5dad5598fc429581ed81
ToppCell	COVID-19-lung-Secretory\|lung / Disease (COVID-19 only), tissue and cell type	EPS8 ARHGEF28 FOXP2 BPIFB1 PTPN13	7.43e-05	189	102	5	84d48e3ed25bebb8bb8074b3a2c5e2e88cff7f25
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC4 FOXP2 DDIT4L IGFBP7 SYNE2	7.62e-05	190	102	5	b855b8b7d3439023390ca44629c1a99f5d4c6801
ToppCell	renal_cortex_nuclei-Hypertensive_with+without-CKD-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	BLNK PTPN13 IL1RAPL2 NFAT5 RASAL1	7.62e-05	190	102	5	11d3c31167ea71809b4cc3757a0c6ea54a448602
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_1\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC4 FOXP2 DDIT4L IGFBP7 SYNE2	7.62e-05	190	102	5	a5db902ad112a0c0a0a7f1a2e38718bb3bd11412
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Inner_Medullary_Collecting_Duct_Cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BLNK PTPN13 IL1RAPL2 CARD11 RASAL1	7.81e-05	191	102	5	3e828cffa24ded19f591a7ed6c1fe88ad57fdcac
ToppCell	wk_20-22-Hematologic_Lymphocytic-B-Late_pre-B\|wk_20-22 / Celltypes from embryonic and fetal-stage human lung	TAGAP BLNK SAG CARD11 RASAL1	7.81e-05	191	102	5	2b05be1888cccd03a32341bcb1de4a899d4179fd
ToppCell	COVID-19-Heart-EC_(POSTN)\|Heart / Disease (COVID-19 only), tissue and cell type	E2F7 CMIP KIAA1549L PWWP3B ENG	8.00e-05	192	102	5	c0c34785a7bdf461722029b322e9184e3d9b3c26
ToppCell	COVID-19-Heart-Fib_+_EC_+_Pericyte\|Heart / Disease (COVID-19 only), tissue and cell type	EPS8 TTC28 PTPN13 IGFBP7 ENG	8.00e-05	192	102	5	60b1312e84f6d6448365a952469c506c00b5fe93
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BLNK PTPN13 IL1RAPL2 CARD11 RASAL1	8.40e-05	194	102	5	04bfc555743f7d8821439d05ae442d15e9886c59
ToppCell	droplet-Heart-4Chambers-21m-Endothelial-endocardial_endothelial_cells\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPS8 KCNC2 PKP2 ENG IPO11	8.40e-05	194	102	5	c5e77650d7abee339ec38fa78a622bb124db3fa5
ToppCell	renal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell\|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group	BLNK PTPN13 IL1RAPL2 CARD11 RASAL1	8.40e-05	194	102	5	69bff17df4a760ccf081cf52ff04af02c14f448d
ToppCell	kidney_cells-Renal_AKI_(acute_kidney_injury)-Epithelial-Intermediate_tubule_epithelial_cell-kidney_loop_of_Henle_thin_descending_limb_epithelial_cell-Descending_Thin_Limb_Cell_Type_2\|Renal_AKI_(acute_kidney_injury) / Celltypes from Cells and Nuclei per compartment and clinical group	ABCC4 DDIT4L TMEM98 SYNE2 NFAT5	8.40e-05	194	102	5	8ddcaaf24cee6e30d5be52c0cbf778cfba309c53
ToppCell	droplet-Heart-4Chambers-21m-Endothelial-endocardial_cell\|Heart / Tongue_Heart_Limb_Muscle_Aorta_Diaphragm - method, tissue, subtissue, age, lineage, cell ontology and free annotation	EPS8 KCNC2 PKP2 ENG IPO11	8.61e-05	195	102	5	df644b4c3ddccd34614ece5a2378000e6bc0fa10
ToppCell	10x5'v1-week_14-16-Lymphocytic_B-B_lineage-immature_B_cell\|week_14-16 / cell types per 3 fetal stages;per 3',per 5'	TAGAP BLNK EPC1 CARD11 RASAL1	8.61e-05	195	102	5	ecaaa3d071e763c40d05d088fbf9e8ca06f78f47
ToppCell	droplet-Pancreas-PANCREAS-30m-Epithelial-pancreatic_B_cell\|Pancreas / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	TTC28 PCLO ASH1L NSD1 HUWE1	8.61e-05	195	102	5	3e519cffa6144a62b06124642a14c9ff39b76554
ToppCell	3'-Child04-06-SmallIntestine-Epithelial-epithelial_progenitor_cell-Stem_cells\|Child04-06 / Celltypes from developing, pediatric, Crohn's, & adult GI tract	ATP10B LGR5 TMEM98 PKP2 NR0B2	8.61e-05	195	102	5	b67d4f34cae729c18275486d3b20c9dd7d5cbe79
ToppCell	renal_papilla_nuclei-Hypertensive_with+without-CKD-Epithelial\|Hypertensive_with+without-CKD / Celltypes from Cells and Nuclei per compartment and clinical group	FOXP2 PTPN13 SYNE2 AKT2 RASAL1	9.03e-05	197	102	5	7e93a97b5ac5ae2f77a4b3141082a1463fed00dd
ToppCell	LPS_anti-TNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_anti-TNF / Treatment groups by lineage, cell group, cell type	ABCC4 ARHGEF28 FOXP2 PTPN13 STRC	9.03e-05	197	102	5	1485933986921ff45669d9b7501c8d17050b3e97
ToppCell	LPS_only-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_only / Treatment groups by lineage, cell group, cell type	ABCC4 ARHGEF28 FOXP2 PTPN13 SYNE2	9.03e-05	197	102	5	1a1bee8da6e04b65935c40373eaee4d6c046d9a1
ToppCell	LPS_IL1RA-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	ABCC4 ARHGEF28 FOXP2 PTPN13 STRC	9.25e-05	198	102	5	285f729140b1df029c24f6ca1d2438470ac51794
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_2\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	EPS8 ABCC4 ARHGEF28 FOXP2 PTPN13	9.25e-05	198	102	5	aa80315395cb5dffc25927c8a77cd2037aea8772
ToppCell	Fetal_29-31_weeks-Epithelial-club_cell-D150\|Fetal_29-31_weeks / Lineage, Cell type, age group and donor	FOXP2 PCLO PTPN13 IL1RAPL2 PWWP3B	9.25e-05	198	102	5	6ba5e5970109a04ed968bac7ff099ae250c579dc
ToppCell	Endothelial_cells-Endothelial-A\|Endothelial_cells / lung cells shred on cell class, cell subclass, sample id	EPS8 NLRP1 SLC3A2 CMIP ENG	9.47e-05	199	102	5	2a1424c61ddcd1fea9574f7a3ad1955387458130
ToppCell	LPS_IL1RA_TNF-Epithelial_alveolar-AT_2-Differentiating_AT2\|LPS_IL1RA_TNF / Treatment groups by lineage, cell group, cell type	EPS8 ABCC4 ARHGEF28 FOXP2 PTPN13	9.69e-05	200	102	5	e8db082aa4d0597500e4f16a5c0ea3e62c6c59ae
ToppCell	Neuronal-Excitatory-eC(RORB)\|Neuronal / cells hierarchy compared to all cells using T-Statistic	FOXP2 PCLO BARD1 NTNG1 IL1RAPL2	9.69e-05	200	102	5	8c803a0ce25e140b46036f6aabefc5502601f408
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-SULF1--L4-6\|Neuronal / cells hierarchy compared to all cells using T-Statistic	TRPC4 TRPC5 BARD1 LGR5 KCNC2	9.69e-05	200	102	5	4a426ef88376d8bb2b9dc50aa06e7b9fc50ecc9c
ToppCell	LPS_only-Endothelial-Endothelial-Vein\|LPS_only / Treatment groups by lineage, cell group, cell type	CMIP KIAA1549L IGFBP7 SYNE2 PLEC	9.69e-05	200	102	5	b036f5e22c95a3b14391785b6e91aa183b9bc9a8
ToppCell	Parenchymal-NucSeq-Immune_Lymphocytic-NK-ILC-T_NK-NK_CD56bright\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ADGRG5 TAGAP E2F7 LGR5 CARD11	9.69e-05	200	102	5	1db27223e307efca97502fca40ec5e4f8eea512b
ToppCell	Neuronal-Excitatory-eC(RORB)-eC_1-TWIST2-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	FOXP2 PCDH11Y BARD1 NTNG1 IL1RAPL2	9.69e-05	200	102	5	af5d4a3d735f38c6e07b5d7bd2965b0486632c4e
ToppCell	Bronchial-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Serous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGEF28 BPIFB1 PKP2 ALDH18A1 RASAL1	9.69e-05	200	102	5	030efc36bbb848da31b0db3f74d46aac9c79cc9b
ToppCell	Tracheal-NucSeq-Epithelial\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGEF28 FOXP2 PCLO BPIFB1 ALDH18A1	9.69e-05	200	102	5	d3af0a706baf66e3f32e67b17dcfc31e5b32ce0e
ToppCell	Bronchial-NucSeq-Epithelial-Epi_submucosal-gland-SMG_Mucous\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGEF28 BPIFB1 PKP2 ALDH18A1 RASAL1	9.69e-05	200	102	5	ed093626a9cac7531a2bf02f6e345c5e84b8c060
ToppCell	LPS_IL1RA-Endothelial-Endothelial-Vein\|LPS_IL1RA / Treatment groups by lineage, cell group, cell type	CMIP KIAA1549L IGFBP7 PLEC ENG	9.69e-05	200	102	5	b3f93b71589251197cde96b7bc6d065c106f61cd
ToppCell	Smart-start-Cell-Wel_seq-Non-neoplastic-Myeloid-TAM-MG-TAM-MG_pro-infl_I-F\|Smart-start-Cell-Wel_seq / Platform, Oncotype, Lineage, Cell_class, celltype (level4), mutation group	ADGRG5 ABCC4 ALPK3 PLEC ENG	9.69e-05	200	102	5	80e0483d5ab0c6213aae0ec62619f57e6ec0e4c2
ToppCell	Neuronal-Excitatory-eC(RORB)-eC_1-TWIST2\|Neuronal / cells hierarchy compared to all cells using T-Statistic	FOXP2 PCDH11Y BARD1 NTNG1 IL1RAPL2	9.69e-05	200	102	5	bbfbefd24cc070b010e787e08ff6bff4a7ee3f7c
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-SULF1\|Neuronal / cells hierarchy compared to all cells using T-Statistic	TRPC4 TRPC5 BARD1 LGR5 KCNC2	9.69e-05	200	102	5	fbeee1c16ac0a7fe28d90491c8b079f21ce80bdc
ToppCell	Neuronal-Inhibitory-iB-iB_2(PVALB)-SULF1-\|Neuronal / cells hierarchy compared to all cells using T-Statistic	TRPC4 TRPC5 BARD1 LGR5 KCNC2	9.69e-05	200	102	5	c6eda342ea0cb37d71d89dbb8d11e819e0745172
ToppCell	Neuronal-Excitatory-eC(RORB)-eC_1-TWIST2--L3-5\|Neuronal / cells hierarchy compared to all cells using T-Statistic	FOXP2 PCDH11Y BARD1 NTNG1 IL1RAPL2	9.69e-05	200	102	5	b9ef0e11c8e22f2c9c926fd48fa2005ef8d22752
ToppCell	Bronchial-NucSeq-Epithelial-Epi_submucosal-gland\|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations	ARHGEF28 BPIFB1 PKP2 ALDH18A1 RASAL1	9.69e-05	200	102	5	85c0f038bcfb42669dca2b80273b0f8a1421405e
Disease	autosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)	STRC STRCP1	1.03e-05	2	95	2	DOID:0110471 (implicated_via_orthology)
Disease	Large cell carcinoma of lung	CDC42BPB MTOR ALPK3	1.50e-04	32	95	3	C0345958
Disease	postherpetic neuralgia	ABCC4 TMEM241	2.84e-04	8	95	2	MONDO_0041052
Disease	disease recurrence, unipolar depression, bipolar disorder, schizophrenia	FOXP2 UBE3D	2.84e-04	8	95	2	EFO_0003761, EFO_0004952, MONDO_0004985, MONDO_0005090
Disease	cerebrospinal fluid biomarker measurement, t-tau measurement	TTC28 AKT2	3.64e-04	9	95	2	EFO_0004760, EFO_0006794
Disease	Complications of Diabetes Mellitus	ABCC4 NR0B2	5.54e-04	11	95	2	C0342257
Disease	nicotine dependence (implicated_via_orthology)	TRPC4 TRPC5	6.63e-04	12	95	2	DOID:0050742 (implicated_via_orthology)
Disease	DEAFNESS, AUTOSOMAL RECESSIVE (disorder)	EPS8 PDZD7	7.82e-04	13	95	2	C1846647
Disease	Leber congenital amaurosis (implicated_via_orthology)	RDH14 RDH13	7.82e-04	13	95	2	DOID:14791 (implicated_via_orthology)
Disease	Tinnitus	PCNX3 E2F7 PTPN13 UBAC2	8.40e-04	130	95	4	HP_0000360
Disease	pancreatitis	HECTD4 PWWP3B	1.20e-03	16	95	2	EFO_0000278
Disease	autism spectrum disorder (implicated_via_orthology)	TRPC4 TRPC5 ASH1L PKP2	1.50e-03	152	95	4	DOID:0060041 (implicated_via_orthology)
Disease	Non-Small Cell Lung Carcinoma	E2F7 MTOR AKT2 KDM1A	1.65e-03	156	95	4	C0007131
Disease	unipolar depression, bipolar disorder, schizophrenia	FOXP2 E2F7	1.88e-03	20	95	2	EFO_0003761, MONDO_0004985, MONDO_0005090
Disease	type 2 diabetes mellitus (is_implicated_in)	IDE MTOR AKT2 NR0B2	2.30e-03	171	95	4	DOID:9352 (is_implicated_in)
Disease	Malignant neoplasm of breast	TRPC4 BARD1 C4orf50 IGFBP7 IL1RAPL2 MTOR SYNE2 ZFYVE26 AKT2 NIPBL	2.41e-03	1074	95	10	C0006142
Disease	body weight	TMEM241 FOXP2 HECTD4 E2F7 NTNG1 HUWE1 IL1RAPL2 UBE3D MTOR RMC1 NIPBL	2.43e-03	1261	95	11	EFO_0004338
Disease	periodontal measurement	ASH1L PKP2	2.70e-03	24	95	2	EFO_0007780
Disease	serum gamma-glutamyl transferase measurement	PCNX3 ASH1L HECTD4 NTNG1 IRAK1 C4orf50 NLRP1 CDC42BPB KDM1A	2.75e-03	914	95	9	EFO_0004532

Protein segments in the cluster

Peptide	Gene	Start	Entry
RTLSPEAKSLLAGLL	AKT2	371	P31751
LSAVPSSALKLAAAA	EPC1	781	Q9H2F5
KLSKSTAPSLALLAD	ASH1L	781	Q9NR48
ADSTTLSKILDALPS	ANKRD30B	941	Q9BXX2
SLLLLPEKNESSSAS	BARD1	541	Q99728
SSLTKDALVLTPASL	BPIFB1	461	Q8TDL5
LLLLLKLSSTETSGA	ALPK3	1166	Q96L96
LTLPSKSTDADLARL	CMIP	641	Q8IY22
SLSSKNPASISELLD	DDIT4L	6	Q96D03
STLTKTLTLLPLLAN	SAG	276	P10523
ALLLASCSLSPTSLA	ENG	11	P17813
LETLSDSRPAKASLS	ATP10B	561	O94823
ADPQTSRSLLLLAKA	RASAL1	491	O95294
LSASLPGLLSDKRDL	NSD1	991	Q96L73
SPLDSLIIKASATDL	PCDHB18P	201	Q96TA0
LPLSSNLQSKESLLS	ARHGEF28	536	Q8N1W1
LKTLPGTRLALLASS	KCNC2	26	Q96PR1
KLSPSAASDAVLSAL	INTS1	1106	Q8N201
KLSALALLSLLPSDN	IPO11	846	Q9UI26
IKPSLAASDELLTSS	FSIP2	786	Q5CZC0
PSDLAKLESTVLSIL	PCLO	1406	Q9Y6V0
PKSQAPLDLSLSLSL	PCNX3	1961	Q9H6A9
SSATAPKLISDLLAE	OR4X2	66	Q8NGF9
ALSESPKTALLLALS	PDZD7	411	Q9H5P4
SVLSASPSLKELDLQ	NLRP1	916	Q9C000
SLQAALAESSLPLLS	FOXP2	611	O15409
TSLLTNKPALLRSLF	NIPBL	2131	Q6KC79
TRDLLLSSKVPNLLS	KIAA1549L	241	Q6ZVL6
LLLLLLPLSSSSSSD	IGFBP7	16	Q16270
SLLGAPSKTSSLLIL	CDC42BPB	1181	Q9Y5S2
SDPASKIASLLLAKL	HECTD4	1466	Q9Y4D8
ELQSSSLSLLLLCPS	HECTD4	3661	Q9Y4D8
SLSLLLLCPSSAVNK	HECTD4	3666	Q9Y4D8
LDSLQLLSSSSLPGL	IRAK1	681	P51617
ASTLKSIPTSLLGDL	NR0B2	221	Q15466
PAARSTASALTKLLT	HUWE1	1096	Q7Z6Z7
ISLLSADLDLESPKS	NFAT5	6	O94916
PLLKRLSLSTSKLNS	ALDH18A1	421	P54886
LKASAPSRIINLSSL	RDH13	161	Q8NBN7
KSSLLSAVLGELAPS	ABCC4	451	O15439
LSKALALTARSLPAV	PRIM2	226	P49643
LLQDSLLATASSPKF	CKAP5	1691	Q14008
TAQLDSLKLPLSLVS	C4orf50	186	Q6ZRC1
KTLALAASSRSPLDS	GCC1	406	Q96CN9
LEFANATPLSTLSLK	KDM1A	536	O60341
KARLTSTLPALTALQ	BLNK	146	Q8WV28
LSSNNLPTKDLLSAL	C2CD3	306	Q4AC94
LASAASAVESLKPAL	E2F7	526	Q96AV8
AAALITLSGDSPLSK	DYTN	111	A2CJ06
LDPALTIAASLAFKS	DHX57	1081	Q6P158
SSLLAAATLAVSPLL	GPR148	56	Q8TDV2
SLSESTLKFLLLNPA	DDX11L8	591	A8MPP1
SASLPAKADLLLSTQ	SLC3A2	586	P08195
LLISDPTTDKSSAAL	IDE	76	P14735
ELASSVLSPLLNKDT	EPS8	376	Q12929
TFTPKLVLLDLSDIS	DHRS7C	91	A6NNS2
LRLSLASSAPTAEKS	FAM186A	1736	A6NE01
SSALLPSAKADLGRI	CEP295	896	Q9C0D2
PLGSLARSSLDATKL	CARD11	926	Q9BXL7
NAFSTLPSLIKLDLS	LGR5	416	O75473
LPSLIKLDLSSNLLS	LGR5	421	O75473
KLDLSSNLLSSFPIT	LGR5	426	O75473
SLASSTLNKLAVRPL	PTPN13	911	Q12923
FLIISSSSSLSPLLL	PCDH11Y	6	Q9BZA8
AIDLVLASSTAPKAL	OR52L1	86	Q8NGH7
LASSTAPKALAVLLV	OR52L1	91	Q8NGH7
RLSLELLKDSSSPSL	MTOR	1286	P42345
LASSFSLSTPLKLIG	FAM167A	186	Q96KS9
SADLLPLDSLKRLGT	NRIP2	96	Q9BQI9
SPALLLLTTLLGTAS	NTNG1	521	Q9Y2I2
LSKSLSAALLTAALL	POMT2	166	Q9UKY4
AALISSKSLSEPLLN	TBC1D25	531	Q3MII6
LPRALVLKAFSSSSL	TAGAP	451	Q8N103
SLLKALSPSDSLEIF	SYNE2	1766	Q8WXH0
DKSLLPSRINLSLLD	PWWP3B	356	Q5H9M0
LLPLSSKELSFTSDI	IL1RAPL2	671	Q9NP60
STPLASFKILALESA	SHKBP1	471	Q8TBC3
TLPESLLSSLVKLNS	SHOC2	321	Q9UQ13
LVLLAFLSPASQKSS	TRGV3	6	P03979
LVLLAFLSPASQKSS	TRGV5	6	A0A0B4J1U4
LTNLLLGLLKSSAPS	RDH14	171	Q9HBH5
EKRLPFSSLSSLASL	RNF169	346	Q8NCN4
SLDPGLSFLKSLLST	STRC	31	Q7RTU9
LSFLKSLLSTLDQAP	STRC	36	Q7RTU9
PALLVLLSLSVKSSV	ADGRG5	366	Q8IZF4
LSLLLSPVLKSSLVT	CLCA3P	11	Q9Y6N3
AALALKGPLLVSTES	RRP7A	131	Q9Y3A4
LADLLEPVKTSSSLA	UTP14C	86	Q5TAP6
SLLAAASRPSKLALG	TIAM2	711	Q8IVF5
VLSDSKPLACLLLSL	RMC1	526	Q96DM3
LLLILSKSNANLPSS	UBE3D	361	Q7Z6J8
SKPDSLLASISLLND	ZNF518A	691	Q6AHZ1
LTGLSLLPLSEKAAR	PLEC	3341	Q15149
TSPAKICSALLLLAA	TMEM241	121	Q24JQ0
LQSLLSLFDSTELPK	TTC28	1931	Q96AY4
SLSGLLSPALTESLL	UPK2	31	O00526
ASLPLLLLLVTSAST	TMEM89	6	A2RUT3
TTTPLFTLALSALLL	SLC35E4	141	Q6ICL7
SLDPGLSFLKSLLST	STRCP1	31	A6NGW2
LSFLKSLLSTLDQAP	STRCP1	36	A6NGW2
KALASPSLIALSSED	TRPC5	201	Q9UL62
SKSLLLVPSALSLLL	UBAC2	16	Q8NBM4
DLLSNLLQSPSSAKL	XPO6	216	Q96QU8
ASPAQLLSKLSVLLL	TKFC	426	Q3LXA3
SLPALTSSALAFLKS	ZFYVE26	1296	Q68DK2
DSSSLALPSEAKLKL	PKP2	26	Q99959
SNSLPLLRSVLDKLS	TMEM33	136	P57088
KALASPSLIALSSED	TRPC4	201	Q9UBN4
DPKLLDARTTALLLS	TMEM98	151	Q9Y2Y6