Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	somatostatin receptor activity	SSTR1 SSTR2	1.24e-04	5	71	2	GO:0004994
GeneOntologyBiologicalProcess	flagellated sperm motility	ENO4 FSIP2 SLC9C1 CCDC146 INPP5B KLC3	4.73e-05	186	72	6	GO:0030317
GeneOntologyBiologicalProcess	sperm motility	ENO4 FSIP2 SLC9C1 CCDC146 INPP5B KLC3	5.81e-05	193	72	6	GO:0097722
GeneOntologyBiologicalProcess	cilium movement involved in cell motility	ENO4 FSIP2 SLC9C1 CCDC146 INPP5B KLC3	9.26e-05	210	72	6	GO:0060294
GeneOntologyBiologicalProcess	cilium-dependent cell motility	ENO4 FSIP2 SLC9C1 CCDC146 INPP5B KLC3	1.05e-04	215	72	6	GO:0060285
GeneOntologyBiologicalProcess	cilium or flagellum-dependent cell motility	ENO4 FSIP2 SLC9C1 CCDC146 INPP5B KLC3	1.05e-04	215	72	6	GO:0001539
GeneOntologyBiologicalProcess	sexual reproduction	FSIP2 HORMAD2 SLC9C1 MYH9 MAGOH PPP3CC SMC3 CCDC146 INPP5B SSTR1 SSTR2 CATSPERG ADAM28 KLC3	1.52e-04	1312	72	14	GO:0019953
GeneOntologyBiologicalProcess	somatostatin receptor signaling pathway	SSTR1 SSTR2	1.79e-04	6	72	2	GO:0038169
GeneOntologyBiologicalProcess	somatostatin signaling pathway	SSTR1 SSTR2	1.79e-04	6	72	2	GO:0038170
GeneOntologyCellularComponent	ATPase inhibitor complex	MAGOH MAGOHB	3.70e-05	3	74	2	GO:1903503
GeneOntologyCellularComponent	exon-exon junction subcomplex mago-y14	MAGOH MAGOHB	3.70e-05	3	74	2	GO:1990501
GeneOntologyCellularComponent	condensed nuclear chromosome	HORMAD2 SMC3 SYN1 HMG20B	3.06e-04	91	74	4	GO:0000794
GeneOntologyCellularComponent	sperm principal piece	ENO4 FSIP2 CATSPERG	5.08e-04	44	74	3	GO:0097228
GeneOntologyCellularComponent	synaptonemal complex	HORMAD2 SMC3 SYN1	5.79e-04	46	74	3	GO:0000795
GeneOntologyCellularComponent	synaptonemal structure	HORMAD2 SMC3 SYN1	5.79e-04	46	74	3	GO:0099086
GeneOntologyCellularComponent	proteasome core complex, beta-subunit complex	PSMB2 PSMB5	6.66e-04	11	74	2	GO:0019774
GeneOntologyCellularComponent	U2-type catalytic step 1 spliceosome	MAGOHB PRPF8	1.09e-03	14	74	2	GO:0071006
GeneOntologyCellularComponent	catalytic step 1 spliceosome	MAGOHB PRPF8	1.09e-03	14	74	2	GO:0071012
GeneOntologyCellularComponent	peptidase complex	PSMB2 PSMB5 SEC11C TRRAP	1.28e-03	133	74	4	GO:1905368
GeneOntologyCellularComponent	motile cilium	ENO4 FSIP2 SLC9C1 PPP3CC CATSPERG KLC3	1.61e-03	355	74	6	GO:0031514
GeneOntologyCellularComponent	sperm head-tail coupling apparatus	FSIP2 CCDC146	1.82e-03	18	74	2	GO:0120212
MousePheno	delayed CNS synapse formation	SYN1 SYN2	4.72e-05	3	56	2	MP:0002924
MousePheno	absent lens vesicle	MAB21L2 MAB21L1	4.72e-05	3	56	2	MP:0009725
Domain	-	MAGOH MAGOHB	1.38e-05	2	70	2	3.30.1560.10
Domain	SYNAPSIN_1	SYN1 SYN2	4.14e-05	3	70	2	PS00415
Domain	SYNAPSIN_2	SYN1 SYN2	4.14e-05	3	70	2	PS00416
Domain	Synapsin_C	SYN1 SYN2	4.14e-05	3	70	2	PF02750
Domain	Synapsin_N	SYN1 SYN2	4.14e-05	3	70	2	PF10581
Domain	Synapsin_pre-ATP-grasp_dom	SYN1 SYN2	4.14e-05	3	70	2	IPR020897
Domain	Synapsin_ATP-bd_dom	SYN1 SYN2	4.14e-05	3	70	2	IPR020898
Domain	Mago_nashi	MAGOH MAGOHB	4.14e-05	3	70	2	IPR004023
Domain	Synapsin_CS	SYN1 SYN2	4.14e-05	3	70	2	IPR019735
Domain	Synapsin_P_site	SYN1 SYN2	4.14e-05	3	70	2	IPR019736
Domain	Mago_nashi	MAGOH MAGOHB	4.14e-05	3	70	2	PF02792
Domain	Synapsin	SYN1 SYN2	4.14e-05	3	70	2	PF02078
Domain	Synapsin	SYN1 SYN2	4.14e-05	3	70	2	IPR001359
Domain	Somatstn_rcpt	SSTR1 SSTR2	1.37e-04	5	70	2	IPR000586
Domain	Mab-21-like_1/2	MAB21L2 MAB21L1	1.37e-04	5	70	2	IPR020950
Domain	GAF_dom-like	PDE6A DHX58	4.90e-04	9	70	2	IPR029016
Domain	-	PDE6A DHX58	4.90e-04	9	70	2	3.30.450.40
Domain	Pept_T1A_subB	PSMB2 PSMB5	6.11e-04	10	70	2	IPR000243
Domain	Proteasome_suB-type	PSMB2 PSMB5	7.45e-04	11	70	2	IPR023333
Domain	PROTEASOME_BETA_1	PSMB2 PSMB5	7.45e-04	11	70	2	PS00854
Domain	PROTEASOME_BETA_2	PSMB2 PSMB5	7.45e-04	11	70	2	PS51476
Domain	Mab-21_dom	MAB21L2 MAB21L1	8.92e-04	12	70	2	IPR024810
Domain	Proteasome_bsu_CS	PSMB2 PSMB5	8.92e-04	12	70	2	IPR016050
Domain	Mab-21	MAB21L2 MAB21L1	8.92e-04	12	70	2	PF03281
Domain	Mab-21	MAB21L2 MAB21L1	8.92e-04	12	70	2	SM01265
Domain	-	SYN1 SYN2	1.05e-03	13	70	2	3.40.50.20
Domain	PreATP-grasp_dom	SYN1 SYN2	1.22e-03	14	70	2	IPR016185
Domain	-	SYN1 SYN2	1.41e-03	15	70	2	3.30.1490.20
Domain	ATP_grasp_subdomain_1	SYN1 SYN2	2.04e-03	18	70	2	IPR013815
Domain	-	SYN1 SYN2	2.04e-03	18	70	2	3.30.470.20
Domain	Proteasome	PSMB2 PSMB5	2.27e-03	19	70	2	PF00227
Domain	Myosin-like_IQ_dom	MYH9 IQGAP1	2.27e-03	19	70	2	IPR027401
Domain	-	MYH9 IQGAP1	2.27e-03	19	70	2	4.10.270.10
Domain	Proteasome_sua/b	PSMB2 PSMB5	2.27e-03	19	70	2	IPR001353
Domain	-	PSMB2 PSMB5	3.62e-03	24	70	2	3.60.20.10
Domain	Arm	ANKAR KPNB1	6.00e-03	31	70	2	PF00514
Domain	ATP_grasp_subdomain_2	SYN1 SYN2	6.00e-03	31	70	2	IPR013816
Domain	Ntn_hydrolases_N	PSMB2 PSMB5	6.78e-03	33	70	2	IPR029055
Pubmed	In-Depth In Vivo Crosslinking in Minutes by a Compact, Membrane-Permeable, and Alkynyl-Enrichable Crosslinker.	ACSL3 MYH9 PDE6A LATS2 RARRES1 ABCB9 RAPH1 CCDC47 SH3PXD2A CCDC150 TNNT1 PRPF8 TTC3 IQGAP1 KPNB1	3.12e-07	1442	74	15	35575683
Pubmed	The protein interaction landscape of the human CMGC kinase group.	ACSL3 MAGOH PSMB2 PSMB5 MAB21L2 PRPF8 ZNF281 VBP1 IQGAP1 KPNB1	2.16e-06	695	74	10	23602568
Pubmed	SERBP1 Promotes Stress Granule Clearance by Regulating 26S Proteasome Activity and G3BP1 Ubiquitination and Protects Male Germ Cells from Thermostimuli Damage.	ACSL3 MYH9 MAGOH CCDC47 ACAD9 CARS1 MAGOHB SELENOI PRPF8 IQGAP1 KPNB1	2.45e-06	878	74	11	37223481
Pubmed	The protein network surrounding the human telomere repeat binding factors TRF1, TRF2, and POT1.	MYH9 SMC3 PSMB5 MCCC2 ZNF281 KPNB1	4.12e-06	197	74	6	20811636
Pubmed	Antiangiogenic role of somatostatin receptor 2 in a model of hypoxia-induced neovascularization in the retina: results from transgenic mice.	SSTR1 SSTR2	4.47e-06	2	74	2	17652715
Pubmed	Seizure elements and seizure element transitions during tonic-clonic seizure activity in the synapsin I/II double knockout mouse: a neuroethological description.	SYN1 SYN2	4.47e-06	2	74	2	19236947
Pubmed	Synapsin I and Synapsin II regulate neurogenesis in the dentate gyrus of adult mice.	SYN1 SYN2	4.47e-06	2	74	2	29721159
Pubmed	The importance of synapsin I and II for neurotransmitter levels and vesicular storage in cholinergic, glutamatergic and GABAergic nerve terminals.	SYN1 SYN2	4.47e-06	2	74	2	19428802
Pubmed	Role of somatostatin receptor-2 in gentamicin-induced auditory hair cell loss in the Mammalian inner ear.	SSTR1 SSTR2	4.47e-06	2	74	2	25268135
Pubmed	A new kinetic framework for synaptic vesicle trafficking tested in synapsin knock-outs.	SYN1 SYN2	4.47e-06	2	74	2	21832187
Pubmed	Electroencephalographic characterization of seizure activity in the synapsin I/II double knockout mouse.	SYN1 SYN2	4.47e-06	2	74	2	21281619
Pubmed	Synapsin-dependent development of glutamatergic synaptic vesicles and presynaptic plasticity in postnatal mouse brain.	SYN1 SYN2	4.47e-06	2	74	2	18606212
Pubmed	Somatostatin receptor gene expression in human ocular tissues: RT-PCR and immunohistochemical study.	SSTR1 SSTR2	4.47e-06	2	74	2	11527930
Pubmed	Modulation of expression of somatostatin receptor subtypes in Graves' ophthalmopathy orbits: relevance to novel analogs.	SSTR1 SSTR2	4.47e-06	2	74	2	17848636
Pubmed	Glutamatergic neurotransmission in the synapsin I and II double knock-out mouse.	SYN1 SYN2	4.47e-06	2	74	2	21827868
Pubmed	Gene expression of somatostatin receptor subtypes, SSTR1 and SSTR2, in human lung cancer cell lines.	SSTR1 SSTR2	4.47e-06	2	74	2	7968260
Pubmed	Distinct patterns of expression and physiological effects of sst1 and sst2 receptor subtypes in mouse hypothalamic neurons and astrocytes in culture.	SSTR1 SSTR2	4.47e-06	2	74	2	9166719
Pubmed	The Male Abnormal Gene Family 21 (Mab21) Members Regulate Eye Development.	MAB21L2 MAB21L1	4.47e-06	2	74	2	27558071
Pubmed	Synapsins I and II are ATP-binding proteins with differential Ca2+ regulation.	SYN1 SYN2	4.47e-06	2	74	2	9430678
Pubmed	Synapsin dispersion and reclustering during synaptic activity.	SYN1 SYN2	4.47e-06	2	74	2	11685225
Pubmed	Functional correlates of somatostatin receptor 2 overexpression in the retina of mice with genetic deletion of somatostatin receptor 1.	SSTR1 SSTR2	4.47e-06	2	74	2	15464758
Pubmed	Synapsin II and calcium regulate vesicle docking and the cross-talk between vesicle pools at the mouse motor terminals.	SYN1 SYN2	4.47e-06	2	74	2	18669537
Pubmed	Altered morphology of rod bipolar cell axonal terminals in the retinas of mice carrying genetic deletion of somatostatin subtype receptor 1 or 2.	SSTR1 SSTR2	4.47e-06	2	74	2	14750962
Pubmed	6agonist selectivity determinants in somatostatin receptor subtypes I and II.	SSTR1 SSTR2	4.47e-06	2	74	2	7929134
Pubmed	Synapsins regulate use-dependent synaptic plasticity in the calyx of Held by a Ca2+/calmodulin-dependent pathway.	SYN1 SYN2	4.47e-06	2	74	2	16481620
Pubmed	Two mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decay.	MAGOH MAGOHB	4.47e-06	2	74	2	23917022
Pubmed	Epileptogenic Q555X SYN1 mutant triggers imbalances in release dynamics and short-term plasticity.	SYN1 SYN2	4.47e-06	2	74	2	23406870
Pubmed	Protective role of somatostatin receptor 2 against retinal degeneration in response to hypoxia.	SSTR1 SSTR2	4.47e-06	2	74	2	22311350
Pubmed	Deletion of synapsins I and II genes alters the size of vesicular pools and rabphilin phosphorylation.	SYN1 SYN2	4.47e-06	2	74	2	16844103
Pubmed	Genomic cloning and chromosomal localization of the mouse Mab21l2 locus.	MAB21L2 MAB21L1	4.47e-06	2	74	2	10516425
Pubmed	Synapsin-I- and synapsin-II-null mice display an increased age-dependent cognitive impairment.	SYN1 SYN2	4.47e-06	2	74	2	18713831
Pubmed	Distinct changes in neuronal and astrocytic amino acid neurotransmitter metabolism in mice with reduced numbers of synaptic vesicles.	SYN1 SYN2	4.47e-06	2	74	2	18346203
Pubmed	Modulation of the neuronal response to ischaemia by somatostatin analogues in wild-type and knock-out mouse retinas.	SSTR1 SSTR2	4.47e-06	2	74	2	18624922
Pubmed	Long-term potentiation in mice lacking synapsins.	SYN1 SYN2	4.47e-06	2	74	2	8606805
Pubmed	Ultrastructural quantification of glutamate receptors at excitatory synapses in hippocampus of synapsin I+II double knock-out mice.	SYN1 SYN2	4.47e-06	2	74	2	16344150
Pubmed	Terminals of the major thalamic input to visual cortex are devoid of synapsin proteins.	SYN1 SYN2	4.47e-06	2	74	2	23535254
Pubmed	Somatostatin receptors differentially affect spontaneous epileptiform activity in mouse hippocampal slices.	SSTR1 SSTR2	4.47e-06	2	74	2	15548214
Pubmed	Synapsins: mosaics of shared and individual domains in a family of synaptic vesicle phosphoproteins.	SYN1 SYN2	4.47e-06	2	74	2	2506642
Pubmed	Absence of synapsin I and II is accompanied by decreases in vesicular transport of specific neurotransmitters.	SYN1 SYN2	4.47e-06	2	74	2	16478532
Pubmed	A delayed response enhancement during hippocampal presynaptic plasticity in mice.	SYN1 SYN2	4.47e-06	2	74	2	17569738
Pubmed	Effects of somatostatin analogues on retinal angiogenesis in a mouse model of oxygen-induced retinopathy: involvement of the somatostatin receptor subtype 2.	SSTR1 SSTR2	4.47e-06	2	74	2	19324858
Pubmed	Expression of somatostatin receptors 1 and 2 in the adult mouse kidney.	SSTR1 SSTR2	4.47e-06	2	74	2	15093692
Pubmed	Synapsin utilization differs among functional classes of synapses on thalamocortical cells.	SYN1 SYN2	4.47e-06	2	74	2	16723536
Pubmed	Synapsins I and II are not required for insulin secretion from mouse pancreatic β-cells.	SYN1 SYN2	4.47e-06	2	74	2	22334712
Pubmed	Depletion of Mab21l1 and Mab21l2 messages in mouse embryo arrests axial turning, and impairs notochord and neural tube differentiation.	MAB21L2 MAB21L1	4.47e-06	2	74	2	11857508
Pubmed	Changes in neuronal response to ischemia in retinas with genetic alterations of somatostatin receptor expression.	SSTR1 SSTR2	4.47e-06	2	74	2	17425570
Pubmed	Sensitive and critical periods in the development of handling induced seizures in mice lacking synapsins: differences between synapsin I and synapsin II knockouts.	SYN1 SYN2	4.47e-06	2	74	2	23570901
Pubmed	Distinct roles of synapsin I and synapsin II during neuronal development.	SYN1 SYN2	4.47e-06	2	74	2	9513186
Pubmed	Synaptic vesicle phosphoproteins and regulation of synaptic function.	SYN1 SYN2	4.47e-06	2	74	2	8430330
Pubmed	Gain of Additional BIRC3 Protein Functions through 3'-UTR-Mediated Protein Complex Formation.	ACSL3 MYH9 SMC3 CCDC47 ACAD9 PSMB2 PSMB5 CARS1 MCCC2 PRPF8 TTC3 IQGAP1 KPNB1	8.85e-06	1425	74	13	30948266
Pubmed	Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage.	ACSL3 MYH9 MAGOH PTCD1 PSMB2 PSMB5 MAGOHB PRPF8 IQGAP1 KPNB1	1.19e-05	844	74	10	25963833
Pubmed	Impaired learning in mice with abnormal short-lived plasticity.	SYN1 SYN2	1.34e-05	3	74	2	8939606
Pubmed	Synapsin selectively controls the mobility of resting pool vesicles at hippocampal terminals.	SYN1 SYN2	1.34e-05	3	74	2	22442064
Pubmed	Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis.	SSTR1 SSTR2	1.34e-05	3	74	2	9892225
Pubmed	Synapsin condensation controls synaptic vesicle sequestering and dynamics.	SYN1 SYN2	1.34e-05	3	74	2	37872159
Pubmed	Synapsin IIa controls the reserve pool of glutamatergic synaptic vesicles.	SYN1 SYN2	1.34e-05	3	74	2	18945891
Pubmed	H3K4 tri-methylation in synapsin genes leads to different expression patterns in bipolar disorder and major depression.	SYN1 SYN2	1.34e-05	3	74	2	22571925
Pubmed	Different presynaptic roles of synapsins at excitatory and inhibitory synapses.	SYN1 SYN2	1.34e-05	3	74	2	15601943
Pubmed	Two distinct phosphorylation events govern the function of muscle FHOD3.	MYOM1 TNNT1	1.34e-05	3	74	2	23052206
Pubmed	Molecular evolution of the synapsin gene family.	SYN1 SYN2	1.34e-05	3	74	2	10578110
Pubmed	Compensatory network alterations upon onset of epilepsy in synapsin triple knock-out mice.	SYN1 SYN2	1.34e-05	3	74	2	21621590
Pubmed	Expression Analysis of SSTR 1, 2 and 3 in Small-cell Lung Cancer Patients as Targets for Future Peptide Receptor Radionuclide Therapy.	SSTR1 SSTR2	1.34e-05	3	74	2	39197921
Pubmed	Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates spontaneous neurotransmitter release.	SYN1 SYN2	1.34e-05	3	74	2	17190793
Pubmed	Purification and biochemical characterization of myomesin, a myosin-binding and titin-binding protein, from bovine skeletal muscle.	MYH9 MYOM1	1.34e-05	3	74	2	7588733
Pubmed	ERK activation in axonal varicosities modulates presynaptic plasticity in the CA3 region of the hippocampus through synapsin I.	SYN1 SYN2	1.34e-05	3	74	2	19487674
Pubmed	Maternal synapsin autoantibodies are associated with neurodevelopmental delay.	SYN1 SYN2	1.34e-05	3	74	2	36742338
Pubmed	Synapsin-dependent reserve pool of synaptic vesicles supports replenishment of the readily releasable pool under intense synaptic transmission.	SYN1 SYN2	1.34e-05	3	74	2	22805168
Pubmed	Autism-related behavioral abnormalities in synapsin knockout mice.	SYN1 SYN2	1.34e-05	3	74	2	23280234
Pubmed	Synapsin Isoforms Regulating GABA Release from Hippocampal Interneurons.	SYN1 SYN2	1.34e-05	3	74	2	27335405
Pubmed	Localization and mRNA expression of somatostatin receptor subtypes in human prostatic tissue and prostate cancer cell lines.	SSTR1 SSTR2	1.34e-05	3	74	2	12474541
Pubmed	The Lack of Synapsin Alters Presynaptic Plasticity at Hippocampal Mossy Fibers in Male Mice.	SYN1 SYN2	1.34e-05	3	74	2	38866497
Pubmed	Epileptic synapsin triple knockout mice exhibit progressive long-term aberrant plasticity in the entorhinal cortex.	SYN1 SYN2	1.34e-05	3	74	2	23236212
Pubmed	Cortico-hippocampal hyperexcitability in synapsin I/II/III knockout mice: age-dependency and response to the antiepileptic drug levetiracetam.	SYN1 SYN2	1.34e-05	3	74	2	20804820
Pubmed	Synapsins differentially control dopamine and serotonin release.	SYN1 SYN2	1.34e-05	3	74	2	20660258
Pubmed	Synapsin 2a tetramerisation selectively controls the presynaptic nanoscale organisation of reserve synaptic vesicles.	SYN1 SYN2	1.34e-05	3	74	2	38472171
Pubmed	Somatostatin actions via somatostatin receptors on the ocular surface are modulated by inflammatory processes.	SSTR1 SSTR2	1.34e-05	3	74	2	19106227
Pubmed	The readily-releasable pool dynamically regulates multivesicular release.	SYN1 SYN2	1.34e-05	3	74	2	31364987
Pubmed	DNA hypomethylation of Synapsin II CpG islands associates with increased gene expression in bipolar disorder and major depression.	SYN1 SYN2	1.34e-05	3	74	2	27515700
Pubmed	Synapsins contribute to the dynamic spatial organization of synaptic vesicles in an activity-dependent manner.	SYN1 SYN2	1.34e-05	3	74	2	22933803
Pubmed	Assembly, disassembly and recycling: the dynamics of exon junction complexes.	MAGOH MAGOHB	1.34e-05	3	74	2	21289489
Pubmed	Synaptic vesicle mobility in mouse motor nerve terminals with and without synapsin.	SYN1 SYN2	1.34e-05	3	74	2	18077680
Pubmed	The Knockout of Synapsin II in Mice Impairs Social Behavior and Functional Connectivity Generating an ASD-like Phenotype.	SYN1 SYN2	1.34e-05	3	74	2	28922833
Pubmed	MAGOH and MAGOHB Knockdown in Melanoma Cells Decreases Nonsense-Mediated Decay Activity and Promotes Apoptosis via Upregulation of GADD45A.	MAGOH MAGOHB	1.34e-05	3	74	2	36497117
Pubmed	Overexpression and functional relevance of somatostatin receptor-1, -2, and -5 in endometrium and endometriotic lesions.	SSTR1 SSTR2	1.34e-05	3	74	2	20739383
Pubmed	Temporal evolution of neurophysiological and behavioral features of synapsin I/II/III triple knock-out mice.	SYN1 SYN2	1.34e-05	3	74	2	22846639
Pubmed	Somatostatin and cannabinoid receptors crosstalk in protection of huntingtin knock-in striatal neuronal cells in response to quinolinic acid.	SSTR1 SSTR2	1.34e-05	3	74	2	31381945
Pubmed	Synaptic and extrasynaptic origin of the excitation/inhibition imbalance in the hippocampus of synapsin I/II/III knockout mice.	SYN1 SYN2	1.34e-05	3	74	2	22368083
Pubmed	Synapsins regulate brain-derived neurotrophic factor-mediated synaptic potentiation and axon elongation by acting on membrane rafts.	SYN1 SYN2	1.34e-05	3	74	2	28245069
Pubmed	Cocaine increases dopamine release by mobilization of a synapsin-dependent reserve pool.	SYN1 SYN2	1.34e-05	3	74	2	16554471
Pubmed	Neuron-specific expression of the synapsin II gene is directed by a specific core promoter and upstream regulatory elements.	SYN1 SYN2	1.34e-05	3	74	2	8034599
Pubmed	Optimized fragmentation schemes and data analysis strategies for proteome-wide cross-link identification.	MYH9 SMC3 PSMB2 PSMB5 PRPF8 VBP1 IQGAP1 KPNB1	1.92e-05	538	74	8	28524877
Pubmed	Different effects on fast exocytosis induced by synaptotagmin 1 and 2 isoforms and abundance but not by phosphorylation.	SYN1 SYN2	2.67e-05	4	74	2	16407561
Pubmed	Differential expression of somatostatin and dopamine receptor subtype genes in adrenocorticotropin (ACTH)-secreting pituitary tumors and silent corticotroph adenomas.	SSTR1 SSTR2	2.67e-05	4	74	2	19318729
Pubmed	Molecular cloning and expression of a type-two somatostatin receptor in goldfish brain and pituitary.	SSTR1 SSTR2	2.67e-05	4	74	2	10996426
Pubmed	Somatostatin receptor types 1 and 2 in the developing mammalian cochlea.	SSTR1 SSTR2	2.67e-05	4	74	2	22986312
Pubmed	Predictive and prognostic significance of tumour subtype, SSTR1-5 and e-cadherin expression in a well-defined cohort of patients with acromegaly.	SSTR1 SSTR2	2.67e-05	4	74	2	33491286
Pubmed	Proteomic profiling of VCP substrates links VCP to K6-linked ubiquitylation and c-Myc function.	ACSL3 MYH9 SMC3 CCDC47 PSMB2 PSMB5 MCCC2 PRPF8 TRRAP ZNF281 IQGAP1 KPNB1	2.70e-05	1353	74	12	29467282
Pubmed	Proteomics analysis of nucleolar SUMO-1 target proteins upon proteasome inhibition.	MYH9 PRPF8 IQGAP1	2.92e-05	28	74	3	19596686
Pubmed	Physiological and pathophysiological characteristics of ataxin-3 isoforms.	MYH9 PSMB2 PSMB5 PRPF8 IQGAP1 KPNB1	3.08e-05	281	74	6	30455355
Pubmed	Assembly of the U5 snRNP component PRPF8 is controlled by the HSP90/R2TP chaperones.	MYH9 RAPH1 SMC3 CCDC47 PSMB2 PSMB5 CARS1 MAGOHB MCCC2 PRPF8 IQGAP1 KPNB1	4.17e-05	1415	74	12	28515276
GeneFamily	Synapsins	SYN1 SYN2	1.90e-05	3	46	2	1325
GeneFamily	Somatostatin receptors	SSTR1 SSTR2	6.30e-05	5	46	2	257
Coexpression	GSE15271_CXCR4_POS_VS_NEG_GC_BCELL_DN	PLBD1 LATS2 SH3PXD2A EIF2AK3 KBTBD7 IQGAP1	1.03e-05	175	74	6	M7101
Coexpression	GSE22342_CD11C_HIGH_VS_LOW_DECIDUAL_MACROPHAGES_UP	MYH9 MAGOH SMC3 PSMB2 CARS1 MAB21L2	2.08e-05	198	74	6	M8131
Coexpression	GSE3982_BASOPHIL_VS_TH2_DN	SLC25A32 PER2 PSMB2 PSMB5 MCCC2 VBP1	2.14e-05	199	74	6	M5567
Coexpression	GSE23568_ID3_KO_VS_WT_CD8_TCELL_DN	PLBD1 PPP3CC PER2 ZNF282 EIF2AK3 IQGAP1	2.20e-05	200	74	6	M8518
Coexpression	BLALOCK_ALZHEIMERS_DISEASE_DN	ACSL3 SLC25A32 AP4S1 TCEAL2 PSMB2 PSMB5 SYN1 SYN2 MCCC2 TTC3 TRRAP VBP1 KPNB1	4.23e-05	1248	74	13	M17728
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DHX58 MYOM1 SLC28A2 SYN1 CARD11 IQGAP1	2.50e-07	157	74	6	ec433d2fe827abdb647be4176c231b7052482b6f
ToppCell	10x5'\|World / Manually curated celltypes from each tissue	SLC25A32 MYH9 PPP3CC PRPF8 EIF2AK3 ADAM28	8.90e-07	195	74	6	de28b998793271c4f69ce9e183c3e62d809e9cc8
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DHX58 MYOM1 SLC28A2 SYN1 EIF2AK3	7.73e-06	163	74	5	8dc0128eeede933537e3bcc5d6ec0322711552f3
ToppCell	droplet-Liver-Hepatocytes-24m-Myeloid-Kupffer_cell\|Liver / Large_Intestine_Pancreas_Liver - method, tissue, subtissue, age, lineage, cell ontology and free annotation	DHX58 MYOM1 SLC28A2 SYN1 EIF2AK3	7.73e-06	163	74	5	fd243ca223079033be480a24817a399f281fa4d4
ToppCell	5'-Adult-SmallIntestine-Hematopoietic-Plasma_cells-IgA_plasma_cell\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PPP3CC ABCB9 RAPGEF1 SEC11C EIF2AK3	1.32e-05	182	74	5	626aabfd9ac662c1d189f7c4b660482914d9e669
ToppCell	5'-Adult-SmallIntestine-Hematopoietic-Plasma_cells\|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract	PPP3CC ABCB9 RAPGEF1 SEC11C EIF2AK3	1.32e-05	182	74	5	a00abff41c12b71d5860c494b8c722d649fd5f36
ToppCell	droplet-Thymus-nan-21m-Lymphocytic-double_negative_T_cell\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	ABCB9 RAPH1 TNNT1 TTC3 ZNF281	1.54e-05	188	74	5	e0184d9f6687d7ecb8fc461294ff7208f49c437c
ToppCell	LV-14._Fibroblast_III\|World / Chamber and Cluster_Paper	SH3PXD2A FGF10 SCLT1 TTC3 EIF2AK3	1.58e-05	189	74	5	3922135d1f6fc768d71ba3b465585fead6ea68a8
ToppCell	LV-14._Fibroblast_III\|LV / Chamber and Cluster_Paper	SH3PXD2A FGF10 SCLT1 TTC3 EIF2AK3	1.79e-05	194	74	5	927c26aea0147f7a4b8fb3f192de4de263f1b978
Disease	glucose-dependent insulinotropic peptide measurement	ABCB9 CCDC141 ADAM28	3.11e-04	53	73	3	EFO_0008464
Disease	Neuroendocrine Tumors	SSTR1 SSTR2	3.27e-04	11	73	2	C0206754
Disease	Global developmental delay	AP4S1 CCDC47 TRRAP MAB21L1	3.37e-04	133	73	4	C0557874
Disease	Petit mal status	SSTR1 SSTR2 EIF2AK3	6.21e-04	67	73	3	C0270823
Disease	Grand Mal Status Epilepticus	SSTR1 SSTR2 EIF2AK3	6.21e-04	67	73	3	C0311335
Disease	Status Epilepticus, Subclinical	SSTR1 SSTR2 EIF2AK3	6.21e-04	67	73	3	C0751522
Disease	Simple Partial Status Epilepticus	SSTR1 SSTR2 EIF2AK3	6.21e-04	67	73	3	C0751524
Disease	Non-Convulsive Status Epilepticus	SSTR1 SSTR2 EIF2AK3	6.21e-04	67	73	3	C0751523
Disease	Complex Partial Status Epilepticus	SSTR1 SSTR2 EIF2AK3	6.21e-04	67	73	3	C0393734
Disease	Status Epilepticus	SSTR1 SSTR2 EIF2AK3	6.49e-04	68	73	3	C0038220
Disease	retinitis pigmentosa (implicated_via_orthology)	PDE6A PRPF8	2.04e-03	27	73	2	DOID:10584 (implicated_via_orthology)
Disease	necrotizing enterocolitis	SYN2 ADAM28	2.04e-03	27	73	2	EFO_0003928
Disease	Seizures	AP4S1 SYN2 SSTR2 TRRAP	2.12e-03	218	73	4	C0036572

Protein segments in the cluster

Peptide	Gene	Start	Entry
KLYQLVYLMNNQKGQ	CATSPERG	586	Q6ZRH7
KVYLYIQMQLCRKEN	EIF2AK3	881	Q9NZJ5
NYVNMLYKKLNTHVA	ADAM28	236	Q9UKQ2
LIQEKFALMAQKAYV	ACAD9	341	Q9H845
STYQDILYQAKQDKM	IQGAP1	256	P46940
GKQLYMNYQEALKRT	RAPH1	506	Q70E73
MAYELLKLKYNQHIN	SLC25A32	201	Q9H2D1
LKQQKYMAEQIGYSF	ANKAR	981	Q7Z5J8
LMVNKQGQTRLSKYY	AP4S1	6	Q9Y587
AKKYYKQLNLVMNEQ	DCDC1	401	M0R2J8
NGLKQSNYNEKVMYV	MINDY3	386	Q9H8M7
LYQENYKQMKALVNQ	MCCC2	41	Q9HCC0
QEQMRKILYQKESNY	LATS2	641	Q9NRM7
NNVVLTMKLHYYNAV	HORMAD2	176	Q8N7B1
KLRYANNSNYKNDVM	MAGOH	31	P61326
NQYLYTGKNLQKMVD	FSIP2	4201	Q5CZC0
LLAYIMNYIIGKNKN	CCDC47	146	Q96A33
KQVKANEEYYQLLMS	PER2	146	O15055
QYQKYKFMELNLAQK	VBP1	56	P61758
LLKYLNFANLIMKVY	PDE6A	211	P16499
MLNILALVYRDQNKY	KLC3	251	Q6P597
MAQQAADKYLYVDKN	MYH9	1	P35579
VVQNYLYAVNSKRML	KBTBD7	481	Q8WVZ9
AKEQHLQKKYMNEVY	RIBC2	351	Q9H4K1
YNNQYMVLDLKKVKL	PLBD1	351	Q6P4A8
AYNLKAQKLLTYQLM	CBLIF	66	P27352
NLKALKYQIQQVDMY	CCDC141	936	Q6ZP82
MNKYLQTKYAQANSE	CCDC150	591	Q8NCX0
QYKRLKNMTSIYLLN	CCR1	61	P32246
QYLIMGKEALQIKYN	C5	1616	P01031
NMLYFNDKQQIIYGK	GDF11	381	O95390
VYNVIMSQYLELKLQ	DHX58	141	Q96C10
LKEYLQIKKYDVNMQ	ANKRD7	41	Q92527
MIAAQAKLVYQLNKY	MAB21L2	1	Q9Y586
AALQNLVKIMSLYYQ	KPNB1	236	Q14974
LQKLKQQAMEYYREN	ENO4	16	A6NNW6
MLYAYDQLKIQVAAK	INPP5B	551	P32019
YKNNTLKLNSVYEAM	SELENOI	246	Q9C0D9
VAVKAINSNYYLAMN	FGF10	121	O15520
INSNYYLAMNKKGKL	FGF10	126	O15520
KVKDDNYNLAMRYAQ	CARD11	196	Q9BXL7
MQLVKYLNFEAINSY	PCDHB3	301	Q9Y5E6
EKQQYMKELRAYQQS	HMG20B	126	Q9P0W2
YANNSNYKNDVMIRK	MAGOHB	36	Q96A72
VQKIGQNYKAYMRTS	SYN1	316	P17600
VQKIGNNYKAYMRTS	SYN2	316	Q92777
YAKMKTATNIYILNL	SSTR1	86	P30872
MAKLKQQKYEINVLY	TNNT1	241	P13805
YYIVKQGKINQMATA	SMC3	136	Q9UQE7
NKRQLYYQVLNFAMI	SEC11C	26	Q9BY50
QEKLYKEYLQMAQNG	CARS1	731	P49589
YNMQLKLSNIYVVDI	SLC9C1	1021	Q4G0N8
MIAAQAKLVYHLNKY	MAB21L1	1	Q13394
QKNVQLYKMRNGYEL	PSMB2	61	P49721
YAKMKTITNIYILNL	SSTR2	71	P30874
YQQLSQYKNKRLSGM	SLC28A2	496	O43868
QQVYKLNRKEAAAYM	ABCB9	396	Q9NP78
SKMREQLLKYQNEYN	CCDC146	121	Q8IYE0
LAYNYKMEQISKGRN	ACSL3	411	O95573
NLYKIAKLQTMNYIA	CYSLTR2	191	Q9NS75
ADYMTAKNNVVINYK	PRPF8	1006	Q6P2Q9
YNNKAAVLKYENNVM	PPP3CC	311	P48454
EHIYQQKNKLLMEVY	RAPGEF1	576	Q13905
MILEQYVVVSNYKKQ	SH3PXD2A	166	Q5TCZ1
KQLNLAMINYVLVVY	TTC3	526	P53804
KASMLQEYSKYLQQA	ZNF281	661	Q9Y2X9
LAQYLKQYKEAIHDM	TCEAL2	146	Q9H3H9
YYQKQVGEMKLQLEN	SCLT1	76	Q96NL6
MNLKNVNYDYSTLVL	ZBED6	946	P86452
VGYLKKAFNLYNQMK	PTCD1	186	O75127
AAASKLLANMVYQYK	PSMB5	136	P28074
QEDYLLYKQMKQLKN	RARRES1	156	P49788
TQIYIKLVKYAMQAL	TRRAP	586	Q9Y4A5
KLVKYAMQALDIYQV	TRRAP	591	Q9Y4A5
ELYNNLVKENYKTLM	ZNF282	221	Q9UDV7
YKISNLKENMVYQFQ	MYOM1	996	P52179