Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	olfactory receptor activity	OR8H2 OR2T29 OR8J2 OR11L1 OR2AK2 OR7E24 OR8D2 OR4K17 OR2G6 OR11H4 OR4F4 OR2W1 OR2AG2 OR5T2 OR2T5 OR10C1 OR2T10 OR10T2 OR6P1 OR4K14 OR2AJ1 OR4F5 OR5AC2 OR12D1 OR5H8 OR2Y1 OR5C1 OR4F17 OR8B12 OR2Z1 OR4X1 OR4K3 OR2AG1	8.03e-26	431	133	33	GO:0004984
GeneOntologyMolecularFunction	G protein-coupled receptor activity	OR8H2 OR2T29 OR8J2 OR11L1 OR2AK2 OR7E24 OR8D2 OR4K17 OR2G6 OR11H4 OR4F4 OR2W1 OR2AG2 TAAR3P OR5T2 OR2T5 OR10C1 OR2T10 OR10T2 OR6P1 OR4K14 OR2AJ1 OR4F5 OR5AC2 OR12D1 OR5H8 MTNR1A MTNR1B OR2Y1 OR5C1 OR4F17 OR8B12 GPR171 OR2Z1 OR4X1 OR4K3 OR2AG1	7.30e-20	884	133	37	GO:0004930
GeneOntologyMolecularFunction	transmembrane signaling receptor activity	OR8H2 OR2T29 OR8J2 OR11L1 OR2AK2 ABCA1 OR7E24 OR8D2 OR4K17 OR2G6 OR11H4 NTRK3 OR4F4 OR2W1 OR2AG2 TAAR3P OR5T2 OR2T5 OR10C1 OR2T10 OR10T2 CHRNA2 OR6P1 OR4K14 OR2AJ1 OR4F5 OR5AC2 OR12D1 OR5H8 MTNR1A MTNR1B OR2Y1 OR5C1 OR4F17 OR8B12 GPR171 OR2Z1 OR4X1 OR4K3 GABRR3 OR2AG1	5.24e-17	1353	133	41	GO:0004888
GeneOntologyMolecularFunction	odorant binding	OR8H2 OR8J2 OR11L1 OR8D2 OR5T2 OR10T2 OR5AC2 OR12D1 OR5H8 OR5C1 OR8B12	8.70e-10	127	133	11	GO:0005549
GeneOntologyMolecularFunction	melatonin receptor activity	MTNR1A MTNR1B	2.62e-04	4	133	2	GO:0008502
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception of smell	OR8H2 OR2T29 OR8J2 OR11L1 OR2AK2 OR7E24 OR8D2 OR4K17 OR2G6 OR11H4 OR4F4 OR2W1 OR2AG2 OR5T2 OR2T5 OR10C1 OR2T10 OR10T2 OR6P1 OR4K14 OR2AJ1 OR4F5 OR5AC2 OR12D1 OR5H8 OR2Y1 OR5C1 OR4F17 OR8B12 OR2Z1 OR4X1 OR4K3 OR2AG1	3.16e-26	432	133	33	GO:0050911
GeneOntologyBiologicalProcess	sensory perception of smell	OR8H2 OR2T29 OR8J2 OR11L1 OR2AK2 OR7E24 OR8D2 OR4K17 OR2G6 OR11H4 OR4F4 OR2W1 OR2AG2 OR5T2 OR2T5 OR10C1 OR2T10 OR10T2 OR6P1 OR4K14 OR2AJ1 OR4F5 OR5AC2 OR12D1 OR5H8 OR2Y1 OR5C1 OR4F17 OR8B12 OR2Z1 OR4X1 OR4K3 OR2AG1	3.35e-25	465	133	33	GO:0007608
GeneOntologyBiologicalProcess	detection of chemical stimulus involved in sensory perception	OR8H2 OR2T29 OR8J2 OR11L1 OR2AK2 OR7E24 OR8D2 OR4K17 OR2G6 OR11H4 OR4F4 OR2W1 OR2AG2 OR5T2 OR2T5 OR10C1 OR2T10 OR10T2 OR6P1 OR4K14 OR2AJ1 OR4F5 OR5AC2 OR12D1 OR5H8 OR2Y1 OR5C1 OR4F17 OR8B12 OR2Z1 OR4X1 OR4K3 OR2AG1	1.28e-24	485	133	33	GO:0050907
GeneOntologyBiologicalProcess	sensory perception of chemical stimulus	OR8H2 OR2T29 OR8J2 OR11L1 OR2AK2 OR7E24 OR8D2 OR4K17 OR2G6 OR11H4 OR4F4 OR2W1 OR2AG2 TAAR3P OR5T2 OR2T5 OR10C1 OR2T10 OR10T2 OR6P1 OR4K14 OR2AJ1 OR4F5 OR5AC2 OR12D1 OR5H8 OR2Y1 OR5C1 OR4F17 OR8B12 OR2Z1 OR4X1 OR4K3 OR2AG1	4.33e-24	547	133	34	GO:0007606
GeneOntologyBiologicalProcess	detection of chemical stimulus	OR8H2 OR2T29 OR8J2 OR11L1 OR2AK2 OR7E24 OR8D2 OR4K17 OR2G6 OR11H4 OR4F4 OR2W1 OR2AG2 OR5T2 OR2T5 OR10C1 OR2T10 OR10T2 OR6P1 OR4K14 OR2AJ1 OR4F5 OR5AC2 OR12D1 OR5H8 OR2Y1 OR5C1 OR4F17 OR8B12 OR2Z1 OR4X1 OR4K3 OR2AG1	1.49e-23	524	133	33	GO:0009593
GeneOntologyBiologicalProcess	detection of stimulus involved in sensory perception	OR8H2 OR2T29 OR8J2 OR11L1 OR2AK2 OR7E24 OR8D2 OR4K17 OR2G6 OR11H4 OR4F4 OR2W1 OR2AG2 OR5T2 OR2T5 OR10C1 OR2T10 OR10T2 OR6P1 OR4K14 OR2AJ1 OR4F5 OR5AC2 OR12D1 OR5H8 PTPRQ OR2Y1 OR5C1 OR4F17 OR8B12 OR2Z1 OR4X1 OR4K3 OR2AG1	3.21e-23	582	133	34	GO:0050906
GeneOntologyBiologicalProcess	detection of stimulus	OR8H2 OR2T29 OR8J2 OR11L1 OR2AK2 OR7E24 OR8D2 OR4K17 OR2G6 OR11H4 TRPC3 OR4F4 OR2W1 OR2AG2 OR5T2 OR2T5 OR10C1 OR2T10 OR10T2 OR6P1 OR4K14 OR2AJ1 OR4F5 OR5AC2 OR12D1 OR5H8 PTPRQ OR2Y1 OR5C1 OR4F17 OR8B12 OR2Z1 OR4X1 OR4K3 OR2AG1	2.97e-21	722	133	35	GO:0051606
GeneOntologyBiologicalProcess	sensory perception	OR8H2 OR2T29 OR8J2 OR11L1 OR2AK2 OR7E24 WDR36 OR8D2 OR4K17 OR2G6 OR11H4 OR4F4 OR2W1 OR2AG2 TAAR3P OR5T2 OR2T5 OR10C1 OR2T10 OR10T2 PKHD1L1 OR6P1 OR4K14 OR2AJ1 OR4F5 LOXHD1 OR5AC2 OR12D1 OR5H8 PTPRQ OR2Y1 OR5C1 OR4F17 OR8B12 TRPM1 GPR171 OR2Z1 MYO15A OR4X1 OR4K3 OR2AG1	3.77e-21	1072	133	41	GO:0007600
GeneOntologyBiologicalProcess	G protein-coupled receptor signaling pathway	OR8H2 OR2T29 OR8J2 OR11L1 OR2AK2 ABCA1 OR7E24 OR8D2 OR4K17 OR2G6 OR11H4 OR4F4 OR2W1 OR2AG2 TAAR3P OR5T2 OR2T5 OR10C1 OR2T10 OR10T2 OR6P1 OR4K14 OR2AJ1 OR4F5 OR5AC2 OR12D1 OR5H8 MTNR1A MTNR1B OR2Y1 OR5C1 OR4F17 OR8B12 TRPM1 GPR171 OR2Z1 OR4X1 OR4K3 OR2AG1	1.89e-15	1395	133	39	GO:0007186
GeneOntologyCellularComponent	stereocilium	MYO1C PKHD1L1 LOXHD1 PTPRQ MYO15A	7.84e-05	69	133	5	GO:0032420
GeneOntologyCellularComponent	RQC complex	LTN1 TCF25	1.20e-04	3	133	2	GO:1990112
GeneOntologyCellularComponent	stereocilium bundle	MYO1C PKHD1L1 LOXHD1 PTPRQ MYO15A	1.49e-04	79	133	5	GO:0032421
GeneOntologyCellularComponent	DNA-dependent protein kinase complex	PRKDC XRCC6	3.97e-04	5	133	2	GO:0070418
GeneOntologyCellularComponent	DNA repair complex	PRKDC ASCC3 XRCC6	4.06e-04	23	133	3	GO:1990391
GeneOntologyCellularComponent	endoplasmic reticulum membrane	PIGY CDC14C AADAC ABCA1 DPY19L3 MOGAT2 PIGS B3GALNT2 DOLK RNF13 PANX1 ATG2A ANKLE2 SBF1 TMEM97 TRPM1 EDEM1 PLOD1 SOAT1	5.42e-04	1293	133	19	GO:0005789
GeneOntologyCellularComponent	cluster of actin-based cell projections	TRPM6 MYO1C PKHD1L1 LOXHD1 SLC19A1 PTPRQ MYO15A	5.71e-04	223	133	7	GO:0098862
GeneOntologyCellularComponent	endoplasmic reticulum subcompartment	PIGY CDC14C AADAC ABCA1 DPY19L3 MOGAT2 PIGS B3GALNT2 DOLK RNF13 PANX1 ATG2A ANKLE2 SBF1 TMEM97 TRPM1 EDEM1 PLOD1 SOAT1	5.73e-04	1299	133	19	GO:0098827
GeneOntologyCellularComponent	nuclear outer membrane-endoplasmic reticulum membrane network	PIGY CDC14C AADAC ABCA1 DPY19L3 MOGAT2 PIGS B3GALNT2 DOLK RNF13 PANX1 ATG2A ANKLE2 SBF1 TMEM97 TRPM1 EDEM1 PLOD1 SOAT1	7.41e-04	1327	133	19	GO:0042175
GeneOntologyCellularComponent	DNA-dependent protein kinase-DNA ligase 4 complex	PRKDC XRCC6	8.26e-04	7	133	2	GO:0005958
GeneOntologyCellularComponent	nonhomologous end joining complex	PRKDC XRCC6	1.40e-03	9	133	2	GO:0070419
Domain	Olfact_rcpt	OR8H2 OR2T29 OR11L1 OR2AK2 OR7E24 OR8D2 OR4K17 OR2G6 OR11H4 OR4F4 OR2W1 OR2AG2 OR5T2 OR2T5 OR10C1 OR2T10 OR10T2 OR6P1 OR4K14 OR2AJ1 OR4F5 OR5AC2 OR2Y1 OR5C1 OR4F17 OR8B12 OR2Z1 OR4X1 OR2AG1	3.64e-22	393	126	29	IPR000725
Domain	7tm_1	OR8H2 OR2T29 OR11L1 OR2AK2 OR7E24 OR8D2 OR4K17 OR2G6 OR11H4 OR4F4 OR2W1 OR2AG2 TAAR3P OR5T2 OR2T5 OR10C1 OR2T10 OR10T2 OR6P1 OR4K14 OR2AJ1 OR4F5 OR5AC2 MTNR1A MTNR1B OR2Y1 OR5C1 OR4F17 OR8B12 GPR171 OR2Z1 OR4X1 OR2AG1	1.31e-19	677	126	33	PF00001
Domain	G_PROTEIN_RECEP_F1_1	OR8H2 OR2T29 OR11L1 OR2AK2 OR7E24 OR8D2 OR4K17 OR2G6 OR11H4 OR4F4 OR2W1 OR2AG2 TAAR3P OR5T2 OR2T5 OR10C1 OR2T10 OR10T2 OR6P1 OR4K14 OR2AJ1 OR4F5 OR5AC2 MTNR1A MTNR1B OR2Y1 OR5C1 OR4F17 OR8B12 GPR171 OR2Z1 OR4X1 OR2AG1	1.88e-19	685	126	33	PS00237
Domain	G_PROTEIN_RECEP_F1_2	OR8H2 OR2T29 OR11L1 OR2AK2 OR7E24 OR8D2 OR4K17 OR2G6 OR11H4 OR4F4 OR2W1 OR2AG2 TAAR3P OR5T2 OR2T5 OR10C1 OR2T10 OR10T2 OR6P1 OR4K14 OR2AJ1 OR4F5 OR5AC2 MTNR1A MTNR1B OR2Y1 OR5C1 OR4F17 OR8B12 GPR171 OR2Z1 OR4X1 OR2AG1	2.45e-19	691	126	33	PS50262
Domain	GPCR_Rhodpsn	OR8H2 OR2T29 OR11L1 OR2AK2 OR7E24 OR8D2 OR4K17 OR2G6 OR11H4 OR4F4 OR2W1 OR2AG2 TAAR3P OR5T2 OR2T5 OR10C1 OR2T10 OR10T2 OR6P1 OR4K14 OR2AJ1 OR4F5 OR5AC2 MTNR1A MTNR1B OR2Y1 OR5C1 OR4F17 OR8B12 GPR171 OR2Z1 OR4X1 OR2AG1	2.56e-19	692	126	33	IPR000276
Domain	GPCR_Rhodpsn_7TM	OR8H2 OR2T29 OR11L1 OR2AK2 OR7E24 OR8D2 OR4K17 OR2G6 OR11H4 OR4F4 OR2W1 OR2AG2 OR5T2 OR2T5 OR10C1 OR2T10 OR10T2 OR6P1 OR4K14 OR4F5 OR5AC2 MTNR1A MTNR1B OR2Y1 OR5C1 OR4F17 OR8B12 GPR171 OR2Z1 OR4X1 OR2AG1	9.01e-18	670	126	31	IPR017452
Domain	Mel_1A_rcpt	MTNR1A MTNR1B	4.52e-05	2	126	2	IPR002278
Domain	DNA_pol_alpha/epsilon_bsu	POLE2 POLA2	1.35e-04	3	126	2	IPR007185
Domain	SBF2	SBF1 SBF2	1.35e-04	3	126	2	PF12335
Domain	DNA_pol_E_B	POLE2 POLA2	1.35e-04	3	126	2	PF04042
Domain	SBF1/SBF2	SBF1 SBF2	1.35e-04	3	126	2	IPR022096
Domain	Melatonin_rcpt	MTNR1A MTNR1B	1.35e-04	3	126	2	IPR000025
Domain	G8	PKHD1L1 PKHD1	2.69e-04	4	126	2	PF10162
Domain	TRPM_tetra	TRPM6 TRPM1	2.69e-04	4	126	2	IPR032415
Domain	G8_domain	PKHD1L1 PKHD1	2.69e-04	4	126	2	IPR019316
Domain	G8	PKHD1L1 PKHD1	2.69e-04	4	126	2	PS51484
Domain	TRPM_tetra	TRPM6 TRPM1	2.69e-04	4	126	2	PF16519
Domain	G8	PKHD1L1 PKHD1	2.69e-04	4	126	2	SM01225
Domain	PbH1	PKHD1L1 PKHD1	6.65e-04	6	126	2	SM00710
Domain	PbH1	PKHD1L1 PKHD1	6.65e-04	6	126	2	IPR006626
Domain	Pectin_lyase_fold/virulence	PKHD1L1 PKHD1	1.23e-03	8	126	2	IPR011050
Domain	Myotubularin-like_Pase_dom	SBF1 SBF2	3.90e-03	14	126	2	IPR010569
Domain	uDENN	SBF1 SBF2	3.90e-03	14	126	2	SM00800
Domain	PPASE_MYOTUBULARIN	SBF1 SBF2	3.90e-03	14	126	2	PS51339
Domain	Myotubularin_fam	SBF1 SBF2	3.90e-03	14	126	2	IPR030564
Domain	Myotub-related	SBF1 SBF2	3.90e-03	14	126	2	PF06602
Domain	HEAT	NCAPG UTP20 PRKDC	4.16e-03	48	126	3	PF02985
Domain	uDENN	SBF1 SBF2	4.48e-03	15	126	2	PF03456
Domain	UDENN	SBF1 SBF2	5.09e-03	16	126	2	PS50946
Domain	DDENN	SBF1 SBF2	5.09e-03	16	126	2	PS50947
Domain	GRAM	SBF1 SBF2	5.09e-03	16	126	2	SM00568
Domain	DENN	SBF1 SBF2	5.09e-03	16	126	2	SM00799
Domain	dDENN	SBF1 SBF2	5.09e-03	16	126	2	SM00801
Domain	DENN	SBF1 SBF2	5.09e-03	16	126	2	PF02141
Domain	dDENN_dom	SBF1 SBF2	5.09e-03	16	126	2	IPR005112
Domain	uDENN_dom	SBF1 SBF2	5.09e-03	16	126	2	IPR005113
Domain	dDENN	SBF1 SBF2	5.09e-03	16	126	2	PF03455
Domain	DENN	SBF1 SBF2	5.09e-03	16	126	2	PS50211
Domain	DENN_dom	SBF1 SBF2	5.09e-03	16	126	2	IPR001194
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR8H2 OR2T29 OR8J2 OR11L1 OR2AK2 OR7E24 OR8D2 OR4K17 OR2G6 OR11H4 OR4F4 OR2W1 OR2AG2 OR5T2 OR2T5 OR10C1 OR2T10 OR10T2 OR6P1 OR4K14 OR2AJ1 OR4F5 OR5AC2 OR2Y1 OR5C1 OR4F17 OR8B12 OR2Z1 OR4X1 OR4K3 OR2AG1	1.34e-22	417	107	31	M4072
Pathway	REACTOME_SENSORY_PERCEPTION	OR8H2 OR2T29 OR8J2 OR11L1 OR2AK2 OR7E24 OR8D2 MYO1C OR4K17 OR2G6 OR11H4 OR4F4 OR2W1 OR2AG2 OR5T2 OR2T5 OR10C1 OR2T10 OR10T2 OR6P1 OR4K14 OR2AJ1 OR4F5 OR5AC2 HSD17B6 OR2Y1 OR5C1 OR4F17 OR8B12 OR2Z1 MYO15A OR4X1 OR4K3 OR2AG1	3.12e-20	636	107	34	M41834
Pathway	KEGG_OLFACTORY_TRANSDUCTION	OR8H2 OR2T29 OR11L1 OR2AK2 OR7E24 OR8D2 OR4K17 OR2G6 OR11H4 OR4F4 OR2W1 OR2AG2 OR5T2 OR2T5 OR10C1 OR2T10 OR10T2 OR4K14 OR4F5 OR5AC2 OR2Y1 OR5C1 OR4F17 OR8B12 OR2Z1 OR4X1 OR2AG1	6.84e-19	389	107	27	M14091
Pathway	REACTOME_OLFACTORY_SIGNALING_PATHWAY	OR2T29 OR11H4 OR4F4 OR2W1 OR2T5 OR6P1	1.47e-05	70	107	6	MM14984
Pubmed	The human olfactory receptor gene family.	OR8H2 OR11L1 OR2AK2 OR7E24 OR8D2 OR4K17 OR11H4 OR4F4 OR2W1 OR2AG2 OR5T2 OR2T5 OR10C1 OR2T10 OR10T2 OR6P1 OR4K14 OR2AJ1 OR5H8 OR2Y1 OR5C1 OR8B12 OR2Z1 OR4X1 OR4K3 OR2AG1	4.22e-21	541	134	26	14983052
Pubmed	Different evolutionary processes shaped the mouse and human olfactory receptor gene families.	OR8H2 OR2T29 OR11L1 OR2AK2 OR7E24 OR8D2 OR11H4 OR4F4 OR2W1 OR2AG2 OR5T2 OR2T5 OR10C1 OR6P1 OR2AJ1 OR12D1 OR5H8 OR2Y1 OR5C1 OR8B12 OR2Z1 OR2AG1	1.02e-20	340	134	22	11875048
Pubmed	The olfactory receptor gene superfamily of the mouse.	OR8H2 OR2T29 OR11L1 OR2AK2 OR7E24 OR8D2 OR11H4 OR4F4 OR2W1 OR2AG2 OR5T2 OR2T5 OR10C1 OR6P1 OR2AJ1 OR12D1 OR5H8 OR2Y1 OR5C1 OR8B12 OR2Z1 OR2AG1	1.02e-20	340	134	22	11802173
Pubmed	A unified nomenclature for vertebrate olfactory receptors.	OR8H2 OR2T29 OR11L1 OR2AK2 OR7E24 OR8D2 OR11H4 OR4F4 OR2W1 OR2AG2 OR5T2 OR2T5 OR10C1 OR6P1 OR2AJ1 OR12D1 OR5H8 OR2Y1 OR5C1 OR8B12 OR2Z1 OR2AG1	1.24e-20	343	134	22	32295537
Pubmed	Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.	OR8H2 OR2T29 OR11L1 OR2AK2 OR7E24 OR8D2 OR11H4 OR4F4 OR2W1 OR2AG2 OR5T2 OR2T5 OR10C1 OR6P1 OR2AJ1 OR12D1 OR5H8 OR2Y1 OR5C1 OR8B12 OR2Z1 OR2AG1	1.50e-20	346	134	22	14611657
Pubmed	Odorant and vomeronasal receptor genes in two mouse genome assemblies.	OR2T29 OR2AK2 OR8D2 OR11H4 OR2W1 OR2T5 OR2AJ1 OR12D1 OR2Y1 OR2Z1	2.99e-13	74	134	10	15081110
Pubmed	DEFOG: a practical scheme for deciphering families of genes.	OR7E24 OR4F4 OR2W1 OR2AG2 OR10C1 OR4K14 OR2Y1 OR8B12 OR2Z1 OR4K3 OR2AG1	1.00e-09	219	134	11	12213199
Pubmed	LRRC31 inhibits DNA repair and sensitizes breast cancer brain metastasis to radiation therapy.	CAD MYO1C SLC25A3 SBF1 LTN1 UTP20 EIF2AK4 PRKDC ASCC3 XRCC6	6.82e-09	202	134	10	33005030
Pubmed	Personal receptor repertoires: olfaction as a model.	OR8J2 OR8D2 OR10C1 OR12D1 OR4X1 OR2AG1	7.29e-09	38	134	6	22908908
Pubmed	A probabilistic classifier for olfactory receptor pseudogenes.	OR8D2 OR10C1 OR6P1 OR4X1 OR2AG1	2.33e-07	35	134	5	16939646
Pubmed	Novel gene function revealed by mouse mutagenesis screens for models of age-related disease.	ABCA1 LOXHD1 PTPRQ MYO15A SLC12A7	7.58e-07	44	134	5	27534441
Pubmed	Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons.	OR7E24 OR2G6 OR11H4 OR6P1 OR4F5	9.51e-07	46	134	5	32126975
Pubmed	Modulation of the combinatorial code of odorant receptor response patterns in odorant mixtures.	OR8H2 OR2AJ1 OR5H8 OR2Y1	3.45e-06	27	134	4	32061665
Pubmed	Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand.	MTNR1A MTNR1B	1.47e-05	2	134	2	22171046
Pubmed	Human gastroenteropancreatic expression of melatonin and its receptors MT1 and MT2.	MTNR1A MTNR1B	1.47e-05	2	134	2	25822611
Pubmed	Melatonin transmits photoperiodic signals through the MT1 melatonin receptor.	MTNR1A MTNR1B	1.47e-05	2	134	2	19261884
Pubmed	MTNR1A and MTNR1B gene polymorphisms in women with gestational diabetes.	MTNR1A MTNR1B	1.47e-05	2	134	2	28084098
Pubmed	DNA-PKcs and Ku70 are predictive markers for poor prognosis of patients with gall bladder malignancies.	PRKDC XRCC6	1.47e-05	2	134	2	25046228
Pubmed	Melatonin in the mammalian olfactory bulb.	MTNR1A MTNR1B	1.47e-05	2	134	2	24365461
Pubmed	Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer.	MTNR1A MTNR1B	1.47e-05	2	134	2	11940583
Pubmed	Association between genetic variations in MTNR1A and MTNR1B genes and gestational diabetes mellitus in Han Chinese women.	MTNR1A MTNR1B	1.47e-05	2	134	2	24157813
Pubmed	MTNR1A and MTNR1B Gene Variants of the Melatonin Receptor and Arterial Stiffness in Persons without Arterial Hypertension.	MTNR1A MTNR1B	1.47e-05	2	134	2	36892670
Pubmed	Homocysteine-mediated cholesterol efflux via ABCA1 and ACAT1 DNA methylation in THP-1 monocyte-derived foam cells.	ABCA1 SOAT1	1.47e-05	2	134	2	23305686
Pubmed	Genetic polymorphisms of melatonin receptors 1A and 1B may result in disordered lipid metabolism in obese patients with polycystic ovary syndrome.	MTNR1A MTNR1B	1.47e-05	2	134	2	30664204
Pubmed	Melatonin Signaling Controls the Daily Rhythm in Blood Glucose Levels Independent of Peripheral Clocks.	MTNR1A MTNR1B	1.47e-05	2	134	2	26824606
Pubmed	Melatonin MT₁ and MT₂ receptors display different molecular pharmacologies only in the G-protein coupled state.	MTNR1A MTNR1B	1.47e-05	2	134	2	24117008
Pubmed	Heteromeric MT1/MT2 melatonin receptors modulate photoreceptor function.	MTNR1A MTNR1B	1.47e-05	2	134	2	24106342
Pubmed	Evidence for feedback control of pineal melatonin secretion.	MTNR1A MTNR1B	1.47e-05	2	134	2	23528860
Pubmed	Positive relationship between melatonin receptor type 1B polymorphism and rheumatoid factor in rheumatoid arthritis patients in the Korean population.	MTNR1A MTNR1B	1.47e-05	2	134	2	16098099
Pubmed	Cyclical regulation of GnRH gene expression in GT1-7 GnRH-secreting neurons by melatonin.	MTNR1A MTNR1B	1.47e-05	2	134	2	11606436
Pubmed	MT1 and MT2 melatonin receptors play opposite roles in brain cancer progression.	MTNR1A MTNR1B	1.47e-05	2	134	2	33392634
Pubmed	Removal of melatonin receptor type 1 increases intraocular pressure and retinal ganglion cells death in the mouse.	MTNR1A MTNR1B	1.47e-05	2	134	2	21362461
Pubmed	Nature's knockout: the Mel1b receptor is not necessary for reproductive and circadian responses to melatonin in Siberian hamsters.	MTNR1A MTNR1B	1.47e-05	2	134	2	8923472
Pubmed	MT(1) melatonin receptor overexpression enhances the growth suppressive effect of melatonin in human breast cancer cells.	MTNR1A MTNR1B	1.47e-05	2	134	2	12088876
Pubmed	Stimulatory effects of a melatonin receptor agonist, ramelteon, on BDNF in mouse cerebellar granule cells.	MTNR1A MTNR1B	1.47e-05	2	134	2	18501512
Pubmed	Sleep-wake characterization of double MT₁/MT₂ receptor knockout mice and comparison with MT₁ and MT₂ receptor knockout mice.	MTNR1A MTNR1B	1.47e-05	2	134	2	23333399
Pubmed	Analysis of genetic variations in the human melatonin receptor (MTNR1A, MTNR1B) genes and antipsychotics-induced tardive dyskinesia in schizophrenia.	MTNR1A MTNR1B	1.47e-05	2	134	2	20726823
Pubmed	Melatonin pathway genes and breast cancer risk among Chinese women.	MTNR1A MTNR1B	1.47e-05	2	134	2	22138747
Pubmed	Food-induced reinforcement is abrogated by the genetic deletion of the MT1 or MT2 melatonin receptor in C3H/HeN mice.	MTNR1A MTNR1B	1.47e-05	2	134	2	29374562
Pubmed	Activation of melatonin receptor 2 but not melatonin receptor 1 mediates melatonin-conferred cardioprotection against myocardial ischemia/reperfusion injury.	MTNR1A MTNR1B	1.47e-05	2	134	2	30903623
Pubmed	Removal of melatonin receptor type 1 induces insulin resistance in the mouse.	MTNR1A MTNR1B	1.47e-05	2	134	2	20168308
Pubmed	Role of polymorphic XRCC6 (Ku70)/XRCC7 (DNA-PKcs) genes towards susceptibility and prognosis of lung cancer patients undergoing platinum based doublet chemotherapy.	PRKDC XRCC6	1.47e-05	2	134	2	29397516
Pubmed	Virtual discovery of melatonin receptor ligands to modulate circadian rhythms.	MTNR1A MTNR1B	1.47e-05	2	134	2	32040955
Pubmed	Targeted deletions of Mel1a and Mel1b melatonin receptors affect pCREB levels in lactotroph and pars intermedia cells of mice.	MTNR1A MTNR1B	1.47e-05	2	134	2	16959416
Pubmed	Description of the constitutive activity of cloned human melatonin receptors hMT(1) and hMT(2) and discovery of inverse agonists.	MTNR1A MTNR1B	1.47e-05	2	134	2	22017484
Pubmed	Murine cell line SX9 bearing a mutation in the dna-pkcs gene exhibits aberrant V(D)J recombination not only in the coding joint but also in the signal joint.	PRKDC XRCC6	1.47e-05	2	134	2	9582343
Pubmed	Preferential formation of MT1/MT2 melatonin receptor heterodimers with distinct ligand interaction properties compared with MT2 homodimers.	MTNR1A MTNR1B	1.47e-05	2	134	2	15266022
Pubmed	Melatonin MT1 and MT2 receptor expression in Parkinson's disease.	MTNR1A MTNR1B	1.47e-05	2	134	2	20110911
Pubmed	Intragenic motifs regulate the transcriptional complexity of Pkhd1/PKHD1.	PKHD1 PRKDC	1.47e-05	2	134	2	24984783
Pubmed	Placental melatonin production and melatonin receptor expression are altered in preeclampsia: new insights into the role of this hormone in pregnancy.	MTNR1A MTNR1B	1.47e-05	2	134	2	22686298
Pubmed	Melatonin receptor mRNA expression in human granulosa cells.	MTNR1A MTNR1B	1.47e-05	2	134	2	10612428
Pubmed	Hepatitis C virus-core protein facilitates the degradation of Ku70 and reduces DNA-PK activity in hepatocytes.	PRKDC XRCC6	1.47e-05	2	134	2	19467273
Pubmed	Melatonin signaling in mouse cerebellar granule cells with variable native MT1 and MT2 melatonin receptors.	MTNR1A MTNR1B	1.47e-05	2	134	2	18621029
Pubmed	Nociceptive responses in melatonin MT2 receptor knockout mice compared to MT1 and double MT1 /MT2 receptor knockout mice.	MTNR1A MTNR1B	1.47e-05	2	134	2	32430930
Pubmed	The hormone melatonin stimulates renoprotective effects of "early outgrowth" endothelial progenitor cells in acute ischemic kidney injury.	MTNR1A MTNR1B	1.47e-05	2	134	2	22357919
Pubmed	C-terminal domains within human MT1 and MT2 melatonin receptors are involved in internalization processes.	MTNR1A MTNR1B	1.47e-05	2	134	2	18341518
Pubmed	Major role of MT2 receptors in the beneficial effect of melatonin on long-term recognition memory in C57BL/6J male mice.	MTNR1A MTNR1B	1.47e-05	2	134	2	34634697
Pubmed	Melatonin 1A and 1B Receptors' Expression Decreases in the Placenta of Women with Fetal Growth Restriction.	MTNR1A MTNR1B	1.47e-05	2	134	2	32804352
Pubmed	Localization of melatonin and its receptors (melatonin 1a and 1b receptors) in the mouse inner ear.	MTNR1A MTNR1B	1.47e-05	2	134	2	31561736
Pubmed	Genetic deletion of MT(1) and MT(2) melatonin receptors differentially abrogates the development and expression of methamphetamine-induced locomotor sensitization during the day and the night in C3H/HeN mice.	MTNR1A MTNR1B	1.47e-05	2	134	2	22672659
Pubmed	Melatonin inhibits embryonic salivary gland branching morphogenesis by regulating both epithelial cell adhesion and morphology.	MTNR1A MTNR1B	1.47e-05	2	134	2	25876057
Pubmed	Targeted disruption of the mouse Mel(1b) melatonin receptor.	MTNR1A MTNR1B	1.47e-05	2	134	2	12529409
Pubmed	E2F mediates induction of the Sp1-controlled promoter of the human DNA polymerase epsilon B-subunit gene POLE2.	POLE2 POLA2	1.47e-05	2	134	2	11433027
Pubmed	Growth retardation and leaky SCID phenotype of Ku70-deficient mice.	PRKDC XRCC6	1.47e-05	2	134	2	9390689
Pubmed	Gender-related invasion differences associated with mRNA expression levels of melatonin membrane receptors in colorectal cancer.	MTNR1A MTNR1B	1.47e-05	2	134	2	21809392
Pubmed	Serine-arginine (SR) protein-like factors that antagonize authentic SR proteins and regulate alternative splicing.	SRSF10 SRSF12	1.47e-05	2	134	2	11684676
Pubmed	Genetic deletion of the MT1 or MT2 melatonin receptors abrogates methamphetamine-induced reward in C3H/HeN mice.	MTNR1A MTNR1B	1.47e-05	2	134	2	24813704
Pubmed	Differential and day-time dependent expression of nuclear receptors RORα, RORβ, RORγ and RXRα in the rodent pancreas and islet.	MTNR1A MTNR1B	1.47e-05	2	134	2	23073388
Pubmed	Melatonin modulates visual function and cell viability in the mouse retina via the MT1 melatonin receptor.	MTNR1A MTNR1B	1.47e-05	2	134	2	19706469
Pubmed	Transcriptional activity of multiple copies of a subtelomerically located olfactory receptor gene that is polymorphic in number and location.	OR4F4 OR4F17	1.47e-05	2	134	2	11689484
Pubmed	Comparative sequencing of a multicopy subtelomeric region containing olfactory receptor genes reveals multiple interactions between non-homologous chromosomes.	OR4F4 OR4F17	1.47e-05	2	134	2	11689483
Pubmed	Melatonin signaling modulates clock genes expression in the mouse retina.	MTNR1A MTNR1B	1.47e-05	2	134	2	25203735
Pubmed	Genetic deletion of MT₁/MT₂ melatonin receptors enhances murine cognitive and motor performance.	MTNR1A MTNR1B	1.47e-05	2	134	2	25046530
Pubmed	Molecular pharmacology of the mouse melatonin receptors MT₁ and MT₂.	MTNR1A MTNR1B	1.47e-05	2	134	2	22202844
Pubmed	Distinct roles for the Charcot-Marie-Tooth disease-causing endosomal regulators Mtmr5 and Mtmr13 in axon radial sorting and Schwann cell myelination.	SBF1 SBF2	1.47e-05	2	134	2	34718573
Pubmed	Impact of melatonin receptor deletion on intracellular signaling in spleen cells of mice after polymicrobial sepsis.	MTNR1A MTNR1B	1.47e-05	2	134	2	25352055
Pubmed	Melatonin in humans.	MTNR1A MTNR1B	1.47e-05	2	134	2	8988899
Pubmed	Family association study between melatonin receptor gene polymorphisms and polycystic ovary syndrome in Han Chinese.	MTNR1A MTNR1B	1.47e-05	2	134	2	26519818
Pubmed	MT1 and MT2 melatonin receptors are expressed in nonoverlapping neuronal populations.	MTNR1A MTNR1B	1.47e-05	2	134	2	30937953
Pubmed	Identification of different proteins binding to Na, K-ATPase α1 in LPS-induced ARDS cell model by proteomic analysis.	CAD WDR36 MYO1C PRKDC G6PD XRCC6	2.11e-05	144	134	6	35681168
Pubmed	Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development.	TRPM6 NTRK3 TRPC3 TRPM1	2.54e-05	44	134	4	19322198
Pubmed	TGFβ attenuates cartilage extracellular matrix degradation via enhancing FBXO6-mediated MMP14 ubiquitination.	PIGS B3GALNT2 TENM4 TMEM131 EDEM1 PLOD1	4.38e-05	164	134	6	32409323
Pubmed	Role of the non-homologous DNA end joining pathway in the early steps of retroviral infection.	PRKDC XRCC6	4.41e-05	3	134	2	11406603
Pubmed	Abnormal DNA-PKcs and Ku 70/80 expression may promote malignant pathological processes in gastric carcinoma.	PRKDC XRCC6	4.41e-05	3	134	2	24187467
Pubmed	Potential role for a specialized β3 integrin-based structure on osteocyte processes in bone mechanosensation.	PANX1 CACNA1H	4.41e-05	3	134	2	29087614
Pubmed	Mapping of protein-protein interactions within the DNA-dependent protein kinase complex.	PRKDC XRCC6	4.41e-05	3	134	2	10446239
Pubmed	Melatonin receptors limit dopamine reuptake by regulating dopamine transporter cell-surface exposure.	MTNR1A MTNR1B	4.41e-05	3	134	2	30043140
Pubmed	Convergence of melatonin and serotonin (5-HT) signaling at MT2/5-HT2C receptor heteromers.	MTNR1A MTNR1B	4.41e-05	3	134	2	25770211
Pubmed	Deletion of individual Ku subunits in mice causes an NHEJ-independent phenotype potentially by altering apurinic/apyrimidinic site repair.	PRKDC XRCC6	4.41e-05	3	134	2	24466051
Pubmed	The DNA-PK catalytic subunit regulates Bax-mediated excitotoxic cell death by Ku70 phosphorylation.	PRKDC XRCC6	4.41e-05	3	134	2	19664609
Pubmed	A role for DNA-PK in retroviral DNA integration.	PRKDC XRCC6	4.41e-05	3	134	2	10213687
Pubmed	Function of DNA-protein kinase catalytic subunit during the early meiotic prophase without Ku70 and Ku86.	PRKDC XRCC6	4.41e-05	3	134	2	12604618
Pubmed	Association of rotating night shift work, CLOCK, MTNR1A, MTNR1B genes polymorphisms and their interactions with type 2 diabetes among steelworkers: a case-control study.	MTNR1A MTNR1B	4.41e-05	3	134	2	37138267
Pubmed	Association Between Functional Polymorphisms of DNA Double-Strand Breaks in Repair Genes XRCC5, XRCC6 and XRCC7 with the Risk of Systemic Lupus Erythematosus in South East Iran.	PRKDC XRCC6	4.41e-05	3	134	2	25756210
Pubmed	DNA-PK is activated by nucleosomes and phosphorylates H2AX within the nucleosomes in an acetylation-dependent manner.	PRKDC XRCC6	4.41e-05	3	134	2	14627815
Pubmed	The antidepressant-like effect of the melatonin receptor ligand luzindole in mice during forced swimming requires expression of MT2 but not MT1 melatonin receptors.	MTNR1A MTNR1B	4.41e-05	3	134	2	16098095
Pubmed	Oxidation of apolipoprotein A-I by myeloperoxidase impairs the initial interactions with ABCA1 required for signaling and cholesterol export.	MPO ABCA1	4.41e-05	3	134	2	20064972
Pubmed	Expression of Melatonin and Dopamine D3 Receptor Heteromers in Eye Ciliary Body Epithelial Cells and Negative Correlation with Ocular Hypertension.	MTNR1A MTNR1B	4.41e-05	3	134	2	31936298
Pubmed	Three-dimensional structure of the human DNA-PKcs/Ku70/Ku80 complex assembled on DNA and its implications for DNA DSB repair.	PRKDC XRCC6	4.41e-05	3	134	2	16713581
Pubmed	Double-strand break repair by Ku70 requires heterodimerization with Ku80 and DNA binding functions.	PRKDC XRCC6	4.41e-05	3	134	2	9362500
Interaction	LRRC31 interactions	CAD MYO1C SLC25A3 SBF1 LTN1 UTP20 EIF2AK4 PRKDC ASCC3 XRCC6	2.38e-07	205	113	10	int:LRRC31
Cytoband	1q44	OR2T29 OR11L1 OR2AK2 OR2G6 OR2T5 OR2T10 OR2AJ1	3.82e-08	110	134	7	1q44
Cytoband	Ensembl 112 genes in cytogenetic band chr1q44	OR2T29 OR11L1 OR2AK2 OR2G6 OR2T5 OR2T10 OR2AJ1	1.09e-07	128	134	7	chr1q44
Cytoband	3q25.1	AADAC RNF13 GPR171	1.24e-04	33	134	3	3q25.1
Cytoband	12q23	SLC25A3 UTP20	1.26e-04	6	134	2	12q23
Cytoband	18q21.1	KATNAL2 LOXHD1 C18orf32	1.90e-04	38	134	3	18q21.1
Cytoband	Ensembl 112 genes in cytogenetic band chr3q11	OR5AC2 OR5H8 GABRR3	5.41e-04	54	134	3	chr3q11
Cytoband	3q12.1	OR5AC2 OR5H8	1.71e-03	21	134	2	3q12.1
Cytoband	14q11.2	OR4K17 OR11H4 OR4K14 OR4K3	1.97e-03	180	134	4	14q11.2
Cytoband	5q33.1	SLC36A1 FAT2	2.62e-03	26	134	2	5q33.1
GeneFamily	Olfactory receptors, family 2	OR2T29 OR2AK2 OR2G6 OR2W1 OR2AG2 OR2T5 OR2T10 OR2AJ1 OR2Y1 OR2Z1 OR2AG1	1.55e-11	113	94	11	149
GeneFamily	Olfactory receptors, family 4	OR4K17 OR4F4 OR4K14 OR4F5 OR4F17 OR4X1 OR4K3	4.89e-06	129	94	7	151
GeneFamily	Melatonin receptors	MTNR1A MTNR1B	2.67e-05	2	94	2	209
GeneFamily	Olfactory receptors, family 8	OR8H2 OR8J2 OR8D2 OR8B12	1.21e-04	49	94	4	155
GeneFamily	Transient receptor potential cation channels	TRPM6 TRPC3 TRPM1	4.06e-04	28	94	3	249
GeneFamily	RNA binding motif containing\|Serine and arginine rich splicing factors	SRSF10 SRSF12	1.71e-03	12	94	2	737
GeneFamily	Myotubularins\|Phosphoinositide phosphatases	SBF1 SBF2	2.69e-03	15	94	2	903
GeneFamily	Olfactory receptors, family 5	OR5T2 OR5AC2 OR5H8 OR5C1	2.77e-03	112	94	4	152
GeneFamily	Cadherin related	CDHR3 FAT2	3.46e-03	17	94	2	24
GeneFamily	DNA helicases	ASCC3 XRCC6	3.46e-03	17	94	2	1167
GeneFamily	Solute carriers	SLC36A1 SLC25A3 SLCO5A1 SLC9A4 SLC44A5 SLC19A1 SLC12A7	4.53e-03	395	94	7	752
GeneFamily	Glycosyl transferases group 1 domain containing\|Phosphatidylinositol glycan anchor biosynthesis	PIGY PIGS	5.27e-03	21	94	2	680
GeneFamily	DNA polymerases	POLE2 POLA2	6.30e-03	23	94	2	535
GeneFamily	Olfactory receptors, family 11	OR11L1 OR11H4	6.30e-03	23	94	2	159
GeneFamily	Guanylate cyclase receptors\|DENN/MADD domain containing	SBF1 SBF2	7.42e-03	25	94	2	504
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-thymocyte\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKHD1L1 FREM2 LOXHD1 TENM4 PTPRQ PKHD1 MYO15A	1.31e-06	184	132	7	2cbed6462fea2622871bb7e49b0df3d984239281
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKHD1L1 FREM2 LOXHD1 TENM4 PTPRQ PKHD1 MYO15A	1.31e-06	184	132	7	ea7a7e2bac46d4d2c31a5d576b38a032b5335062
ToppCell	facs-Thymus-Thymus_Epithelium-18m-Lymphocytic-proliferating_thymocyte;_DN_to_DP_transition,_dividing_(some_are_Cd8+/_Cd4+,_some_undergoing_VDJ_recombination)\|Thymus / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation	PKHD1L1 FREM2 LOXHD1 TENM4 PTPRQ PKHD1 MYO15A	1.31e-06	184	132	7	2b19a8c5f823e00812908b23e66bb4e563278aff
ToppCell	facs-Lung-24m-Endothelial-capillary_endothelial-capillary_endothelial_cell-capillary_type_1_endothelial_cell\|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype	NTRK3 PKHD1L1 FREM2 KIAA1549L PTPRQ PKHD1	8.94e-06	162	132	6	bf886e22ff2a20353499004b53f25fb9e6574896
Drug	azide radical	MPO MTNR1A MTNR1B	3.59e-06	6	130	3	CID006857664
Drug	Melatonin	MPO MTNR1A MTNR1B	6.26e-06	7	130	3	DB01065
Drug	AFMK	MPO MTNR1A MTNR1B	2.90e-05	11	130	3	CID000171161
Drug	tetrahydrophenanthrene	MTNR1A MTNR1B	3.24e-05	2	130	2	CID000136808
Drug	2-chloromelatonin	MTNR1A MTNR1B	3.24e-05	2	130	2	CID000195276
Drug	Phenalenes	MTNR1A MTNR1B	3.24e-05	2	130	2	ctd:D043803
Drug	Ramelteon	MTNR1A MTNR1B	3.24e-05	2	130	2	DB00980
Drug	cyclo(Leu-Trp	MTNR1A MTNR1B	3.24e-05	2	130	2	CID003082081
Drug	4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid	PANX1 SLC19A1	3.24e-05	2	130	2	ctd:D012856
Drug	N-(2-(2-ethyl-8,9-dihydrofuro(3,2-c)pyrazolo(1,5-a)pyridin-1-yl)ethyl)acetamide	MTNR1A MTNR1B	3.24e-05	2	130	2	ctd:C561057
Drug	3-acetylindole	MTNR1A MTNR1B	3.24e-05	2	130	2	CID000012802
Drug	IIK7	MTNR1A MTNR1B	3.24e-05	2	130	2	CID004172142
Disease	Massive Hepatic Necrosis	PANX1 PRKDC	1.64e-05	2	120	2	C0001364
Disease	status asthmaticus (is_marker_for)	MPO IL5	4.91e-05	3	120	2	DOID:9362 (is_marker_for)
Disease	reticulocyte measurement	OR11L1 ABCA1 DPY19L3 RAP1GAP OR10T2 DMRT2 SLC19A1 SBF2 LTN1 TCF25 TMEM131 EIF2AK4 SLC12A7 SOAT1	9.93e-05	1053	120	14	EFO_0010700
Disease	Alzheimer disease, whole-brain volume	ABCA1 SLC44A5	1.63e-04	5	120	2	EFO_0005089, MONDO_0004975
Disease	Adenocarcinoma of lung (disorder)	TRPM6 NTRK3 SLC19A1 EIF2B4 PRKDC XRCC6	2.03e-04	206	120	6	C0152013
Disease	Abnormal muscle tone	RNF13 ZNF292	2.43e-04	6	120	2	C0852413
Disease	pantothenate measurement	ABCA1 CAD	4.52e-04	8	120	2	EFO_0021034
Disease	autosomal recessive polycystic kidney disease (biomarker_via_orthology)	PANX1 PKHD1	8.81e-04	11	120	2	DOID:0110861 (biomarker_via_orthology)
Disease	lipoprotein measurement	ABCA1 MOGAT2 TMEM97 MCUB	9.06e-04	105	120	4	EFO_0004732
Disease	Cooley's anemia	CAD CACNA1H	1.05e-03	12	120	2	C0002875
Disease	Thalassemia Intermedia	CAD CACNA1H	1.05e-03	12	120	2	C0271979
Disease	Thalassemia Minor	CAD CACNA1H	1.05e-03	12	120	2	C0085578
Disease	beta Thalassemia	CAD CACNA1H	1.05e-03	12	120	2	C0005283
Disease	Nonsyndromic Hearing Loss and Deafness, Autosomal Recessive	LOXHD1 PTPRQ MYO15A	1.18e-03	51	120	3	cv:CN043650
Disease	Charcot-Marie-Tooth disease type 4	SBF1 SBF2	1.24e-03	13	120	2	cv:C4082197
Disease	abdominal adipose tissue measurement	UBOX5 DMRT2 PKHD1	1.32e-03	53	120	3	EFO_0803316
Disease	Hemoglobin F Disease	CAD CACNA1H	1.66e-03	15	120	2	C0019025
Disease	Feeding difficulties	RNF13 ZNF292	2.40e-03	18	120	2	C0232466
Disease	phospholipids:total lipids ratio, intermediate density lipoprotein measurement	ABCA1 MOGAT2 MCUB	2.60e-03	67	120	3	EFO_0008595, EFO_0020946
Disease	renovascular hypertension (biomarker_via_orthology)	MPO G6PD	2.68e-03	19	120	2	DOID:1591 (biomarker_via_orthology)
Disease	response to ziprasidone	TENM4 ZP4	2.97e-03	20	120	2	GO_0097337
Disease	respiratory symptom measurement, COVID-19	NTRK3 FREM2 MTNR1A	3.45e-03	74	120	3	EFO_0007939, MONDO_0100096
Disease	Nonsyndromic genetic hearing loss	LOXHD1 PTPRQ MYO15A	3.72e-03	76	120	3	cv:C5680182
Disease	diet measurement	KATNAL2 OR4K17 PIGS TRPC3 RNF13 UBOX5 TENM4 PKHD1 CACNA1H PRKDC MDGA1	3.72e-03	1049	120	11	EFO_0008111
Disease	Alzheimer disease	ABCA1 MYO1C DSG2 CDHR3 HS3ST5 PKHD1 MYO15A	3.75e-03	485	120	7	MONDO_0004975
Disease	arginine measurement	PYROXD2 HSD17B6	3.92e-03	23	120	2	EFO_0020990

Protein segments in the cluster

Peptide	Gene	Start	Entry
ITPYLVSRFYRAPEI	PRPF4B	846	Q13523
YYVPLLRAEETSSPV	ANKLE2	476	Q86XL3
FLPTAEIIYTIYEII	EIF2AK4	1171	Q9P2K8
VGILIAYYIYTPLPD	AADAC	11	P22760
FLILISVRLSYPPYE	ABCA1	36	O95477
IYPDVTYAFVIRRLP	CHRNA2	251	Q15822
TYAFVIRRLPLFYTI	CHRNA2	256	Q15822
DYALRVYPVPDLLVI	POLE2	466	P56282
EIKRNLPPYVAYFTR	DPY19L3	686	Q6ZPD9
AYRILIFGDTPYIPF	CDC14C	121	A4D256
VDYRPLYLPVRVLIT	ATG2A	1121	Q2TAZ0
EPYIYPLVSPFVSRI	C18orf32	21	Q8TCD1
IPYGSLEEVIPYLIR	PRODH2	486	Q9UF12
YSRPSVLIVTYKEPA	RIC1	46	Q4ADV7
RLFYLALPPTVYEAV	G6PD	136	P11413
IYFSAALYRIPKPEL	PAQR5	311	Q9NXK6
FYTVIIPFLNPIIYS	OR5H8	276	P0DN80
ATVIYPYLLPFISKL	LTN1	356	O94822
ISYRIVSLEPAYPPV	DSG2	196	Q14126
LRVPHSYEVRLTPYT	MDGA1	711	Q8NFP4
PEEVLEYILSFLSPY	FBXO42	51	Q6P3S6
VFYTIVIPVLNPLIY	OR8H2	276	Q8N162
LVYSVTTPLFNPLIY	OR11H4	286	Q8NGC9
VFYTIVTPALNPLIY	OR2AG2	276	A6NM03
VFYTIVTPLLNPFIY	OR2AK2	291	Q8NG84
IFLIALSSQLYPPVY	OR8D2	46	Q9GZM6
FIYDSVKVYFRLPRP	SLC25A3	331	Q00325
YSTVVPPDEITVIYR	MCUB	51	Q9NWR8
ATYIPGIIFDRPLLY	DOLK	346	Q9UPQ8
RYFVTEVLDVIAPPY	NELFCD	531	Q8IXH7
SVALTVYYPPRVVSL	NTRK3	296	Q16288
FAPKSLVLVSRLYYP	SBF2	116	Q86WG5
RSPIFFNYLYSPLEI	SBF2	1551	Q86WG5
FYLPSVREVQEYIPA	MYO15A	3356	Q9UKN7
VRPVLLTLYEKYFLP	DOP1B	121	Q9Y3R5
KAVPLISRLLYYVFP	DOP1B	1921	Q9Y3R5
TLRVPLYVSYVFHSP	FREM2	2671	Q5SZK8
DLVVAFYPYPLILVA	MTNR1B	86	P49286
LQTRLYTPFVPYEIT	LOXHD1	1091	Q8IVV2
SPAYFITEEVPERIY	HS3ST5	156	Q8IZT8
LVPIVPLSFILTYQY	PLGRKT	81	Q9HBL7
YKVRVPENITLYTPI	FAT2	2176	Q9NYQ8
FYTILTPVLNPLIYS	OR2T5	281	Q6IEZ7
LFYTVITPSLNPLIY	OR2W1	276	Q9Y3N9
FYTIITPILNPLIYT	OR2Y1	276	Q8NGV0
LFYSLVTPTLNPLIY	OR2Z1	276	Q8NG97
VFYSVITPLLNPIIY	OR4F5	266	Q8NH21
PIDKVLSVFYTIYTP	OR4K3	266	Q96R72
LSVFYTIYTPLLNPV	OR4K3	271	Q96R72
TIYTPLLNPVIYTVR	OR4K3	276	Q96R72
YTIFTPLLNPIIYTL	OR4K14	276	Q8NGD5
VFYTIITPILNPIIY	OR4K17	276	Q8NGC6
VFYTVVTPLLNPVIY	OR4X1	271	Q8NH49
VKEAVVYPIRYPQLF	KATNAL2	266	Q8IYT4
VYPIRYPQLFTGILS	KATNAL2	271	Q8IYT4
IITYRDYLPLVLGPT	MPO	456	P05164
LYYVALPRALAPAVT	FAM205A	791	Q6ZU69
LYYVALPRALAPAVT	FAM205BP	521	Q63HN1
FVPYHIVRIPYTLSQ	GPR171	236	O14626
LPEPLLTFEYYELFV	DEPDC1	286	Q5TB30
CLEVVSIYYTLPRKP	EXPH5	1246	Q8NEV8
AELVGFYLTYPPLTI	KIAA1549L	1026	Q6ZVL6
VFYTVVTPLLNPVIY	OR11L1	276	Q8NGX0
VFYTIVTPALNPLIY	OR2AG1	276	Q9H205
VFYSVITPLLNPIIY	OR4F17	266	Q8NGA8
FYTLVIPSLNPLIYS	OR5C1	281	Q8NGR4
LLAPVVVYTLFVPFR	PANX1	286	Q96RD7
VPASYLLIPAASYVL	EIF2B4	381	Q9UI10
LIYPDRRLETKYPVV	PLOD1	131	Q02809
ALLFPLRYSFTYVPI	SBF1	256	O95248
LRYSFTYVPILPAQL	SBF1	261	O95248
VRPPLVTYERSIYFD	PTPRQ	1141	Q9UMZ3
VTYTVVTPLLNPLVY	OR10T2	276	Q8NGX3
YTVVTPVLNPLIYTL	OR12D1	271	P0DN82
FFYTILTPVLNPIIY	OR2T10	276	Q8NGZ9
FYTILTPVLNPLIYS	OR2T29	281	Q8NH02
TYRLQYIYDILLPVP	PPP4R3C	266	Q6ZMV5
YIYDILLPVPSIFED	PPP4R3C	271	Q6ZMV5
LYASVSLYLLPERPA	FAM171A2	116	A8MVW0
YSLFYTIIIPLLNPF	OR5AC2	276	Q9NZP5
VFYTLVIPVLNPLIY	OR8J2	276	Q8NGG1
VFQYSFGLIPYRRPI	MOGAT2	266	Q3SYC2
FYTIIVPVLNPLIYS	OR8B12	276	Q8NGG6
VLYTIIVPFFNPAIY	OR6P1	276	Q8NGX9
FRDLPIPVITYDTYS	CHN2	356	P52757
YRTPEIIDLYSNFPI	GAK	226	O14976
HVIDTYSRILFPIVY	GABRR3	441	A8MPY1
YVYAIPTEIPTSALV	IL5	16	P05113
FIPLSYLPTSLADYI	HSD17B6	291	O14756
SILEGYRPIPAETYV	DMRT2	206	Q9Y5R5
LSFLLYNYDLPVPVI	GNPAT	171	O15228
YVYILTSPENEFPLI	CDHR3	446	Q6ZTQ4
VLYPIVITSLGVFYD	B3GALNT2	151	Q8NCR0
FLYLEAAARSIPPIY	C19orf67	136	A6NJJ6
LFYPLRPELVESTYL	EDEM1	486	Q92611
YVPSTLVYPALTFIL	SLC44A5	366	Q8NCS7
PSVYTYEVSPVFLLV	GADL1	141	Q6ZQY3
YLPALSPVYFVTFVL	CACNA1H	1831	O95180
YILGTIEIFLTYISP	SLC12A7	216	Q9Y666
YVSLTYADLIPVPLT	CRLS1	181	Q9UJA2
IAAVFYVRYRTLPTP	CRLS1	206	Q9UJA2
FYAVVTPILNPIIYS	OR10C1	276	Q96KK4
IFYTILTPTLNPFIY	OR2AJ1	276	Q8NGZ0
LFYTIVTPLLNPIIY	OR2G6	276	Q5TZ20
VFYSVITPLLNPIIY	OR4F4	266	Q96R69
ASLYPVLNFLLYVPE	PIGS	316	Q96S52
VLIDPYLDYSTPILI	TAAR3P	276	Q9P1P4
FPLEPSVLLLTDLYY	UTP20	596	O75691
FRTEYFIKPPVYVTV	UBOX5	41	O94941
PIVIYQTLVYPRAAK	TRIM42	606	Q8IWZ5
YVVLAYTLPPASRFI	SOAT1	241	P35610
LKLPYSTFRTYLFPE	TBX3	261	O15119
YYKIVSPILRVPTSD	OR7E24	236	Q6IFN5
LTYLLLPCTLPFEYI	PNPLA5	341	Q7Z6Z6
ILVPEFSLPLEYYLI	RNF13	171	O43567
VDRFYPVLYPKASRL	RAP1GAP	166	P47736
DSSIYFLYLLPPIVL	SLC9A4	126	Q6AI14
VLLRTLAYIPTPIYF	SLCO5A1	691	Q9H2Y9
IYIRPYALSILVQPS	PKHD1	3736	P08F94
YVYAQLPVTPDVLII	POLA2	526	Q14181
FYTIVIPLLNPVIYS	OR5T2	316	Q8NGG2
IVDVYIPLDFYTRRP	SRSF12	36	Q8WXF0
TIPIFEPLPSQYYIR	ASCC3	1256	Q8N3C0
LPEPVVYADYLLSYI	NCAPG	361	Q9BPX3
YLRPSLFVYPEESLV	XRCC6	361	P12956
TIPYTPRFLEVFLIY	TRPM6	1851	Q9BX84
TYALQFYVPAEIIIP	SLC36A1	346	Q7Z2H8
IVDVYVPLDFYTRRP	SRSF10	36	O75494
LPRYYEVLTAPITKV	PYROXD2	216	Q8N2H3
VPVFLLTDYLRYTPV	SLC19A1	81	P41440
VRVYTGFLDYFVLPP	TMEM131	531	Q92545
CFYSLLLPITIPVYV	PIGY	41	Q3MUY2
PLPLLEVYTVAIQSY	ZNF292	71	O60281
AVINETPLPIDLYRY	TENM4	2096	Q6N022
IAYPPLLFTYALEDT	PKHD1L1	1901	Q86WI1
LTLVSVYAPYLLIPF	TMEM97	141	Q5BJF2
YFLPITPHYVTQVIR	CAD	451	P27708
LLYLDTVPEVYTPVL	PRKDC	421	P78527
ISYPLEETKITRYFP	TRPM1	1411	Q7Z4N2
PIAVLLTYPLTVYYV	ZMYND15	476	Q9H091
TIYSYVRPERLSPIS	TCF25	591	Q9BQ70
YPVVKLLRDPIYVEV	ZP4	336	Q12836
VTLPPEIQYFTYARD	TRPC3	501	Q13507
LYSVVSLRPLPADYV	WDR36	696	Q8NI36
VADLVVAIYPYPLVL	MTNR1A	71	P48039
FRENLIYTYIGPVLV	MYO1C	71	O00159