Cluster composition

Functions

CategoryNameIntersectionWithQueryPValueGenesInTermGenesInQueryGenesInTermInQueryID
GeneOntologyMolecularFunctionacetyl-CoA carboxylase activity

ACACA ACACB

2.81e-062342GO:0003989
GeneOntologyMolecularFunctionbiotin binding

ACACA ACACB

4.20e-056342GO:0009374
GeneOntologyMolecularFunctionCoA carboxylase activity

ACACA ACACB

4.20e-056342GO:0016421
GeneOntologyMolecularFunctionligase activity, forming carbon-carbon bonds

ACACA ACACB

5.88e-057342GO:0016885
GeneOntologyMolecularFunctionvitamin binding

ACACA ACACB MMUT

2.56e-03161343GO:0019842
GeneOntologyBiologicalProcessmalonyl-CoA biosynthetic process

ACACA ACACB

2.48e-062332GO:2001295
GeneOntologyBiologicalProcessmalonyl-CoA metabolic process

ACACA ACACB

3.71e-056332GO:2001293
GeneOntologyBiologicalProcessthioester biosynthetic process

ACACA ACACB MMUT

6.54e-0549333GO:0035384
GeneOntologyBiologicalProcessacyl-CoA biosynthetic process

ACACA ACACB MMUT

6.54e-0549333GO:0071616
GeneOntologyBiologicalProcessribonucleoside bisphosphate biosynthetic process

ACACA ACACB MMUT

1.26e-0461333GO:0034030
GeneOntologyBiologicalProcesspurine nucleoside bisphosphate biosynthetic process

ACACA ACACB MMUT

1.26e-0461333GO:0034033
GeneOntologyBiologicalProcessnucleoside bisphosphate biosynthetic process

ACACA ACACB MMUT

1.26e-0461333GO:0033866
DomainAcCoA_COase_cen

ACACA ACACB

3.03e-062332IPR013537
DomainACC_central

ACACA ACACB

3.03e-062332PF08326
DomainCarboxyl_trans

ACACA ACACB

1.81e-054332PF01039
DomainCOA_CT_N

ACACA ACACB

1.81e-054332IPR011762
DomainCOA_CT_C

ACACA ACACB

1.81e-054332IPR011763
DomainCOA_CT_CTER

ACACA ACACB

1.81e-054332PS50989
DomainCarboxyl_trans

ACACA ACACB

1.81e-054332IPR000022
DomainCOA_CT_NTER

ACACA ACACB

1.81e-054332PS50980
DomainBiotin_COase_C

ACACA ACACB

3.02e-055332IPR005482
DomainBiotin_BS

ACACA ACACB

3.02e-055332IPR001882
DomainBiotin_carb_C

ACACA ACACB

3.02e-055332SM00878
DomainBiotin_carb_C

ACACA ACACB

3.02e-055332PF02785
DomainBiotin_carboxylation_dom

ACACA ACACB

3.02e-055332IPR011764
DomainBIOTIN

ACACA ACACB

3.02e-055332PS00188
DomainCPSASE_1

ACACA ACACB

3.02e-055332PS00866
DomainBC

ACACA ACACB

3.02e-055332PS50979
DomainRudment_hybrid_motif

ACACA ACACB

4.52e-056332IPR011054
DomainCPSASE_2

ACACA ACACB

4.52e-056332PS00867
DomainCbamoylP_synth_lsu-like_ATP-bd

ACACA ACACB

6.32e-057332IPR005479
DomainBC-like_N

ACACA ACACB

6.32e-057332IPR005481
DomainBiotin_carb_N

ACACA ACACB

6.32e-057332PF00289
DomainCPSase_L_D2

ACACA ACACB

6.32e-057332PF02786
DomainBiotin_lipoyl

ACACA ACACB

1.08e-049332PF00364
DomainBiotin_lipoyl

ACACA ACACB

1.35e-0410332IPR000089
DomainBIOTINYL_LIPOYL

ACACA ACACB

1.35e-0410332PS50968
DomainSingle_hybrid_motif

ACACA ACACB

1.98e-0412332IPR011053
Domain-

ACACA ACACB

2.33e-04133323.40.50.20
DomainATP-grasp

ACACA ACACB

2.72e-0414332IPR011761
DomainPreATP-grasp_dom

ACACA ACACB

2.72e-0414332IPR016185
DomainATP_GRASP

ACACA ACACB

2.72e-0414332PS50975
Domain-

ACACA ACACB

3.13e-04153323.30.1490.20
Domain-

ACACA ACACB

4.55e-04183323.30.470.20
DomainATP_grasp_subdomain_1

ACACA ACACB

4.55e-0418332IPR013815
Domain-

ACACA ACACB

6.23e-04213323.90.226.10
DomainClpP/crotonase-like_dom

ACACA ACACB

6.23e-0421332IPR029045
Domainzf-C2H2_jaz

ZNF622 ZFR

6.84e-0422332PF12171
DomainZnf_C2H2_jaz

ZNF622 ZFR

6.84e-0422332IPR022755
DomainZnF_U1

ZNF622 ZFR

1.19e-0329332SM00451
DomainZnf_U1

ZNF622 ZFR

1.19e-0329332IPR003604
DomainATP_grasp_subdomain_2

ACACA ACACB

1.36e-0331332IPR013816
DomainEGF_CA

LRP2 EGFL8

1.01e-0286332PF07645
PathwayKEGG_PROPANOATE_METABOLISM

ACACA ACACB MMUT

2.00e-0533233M4086
PathwayREACTOME_METABOLISM_OF_WATER_SOLUBLE_VITAMINS_AND_COFACTORS

LRP2 ACACA ACACB MMUT

3.90e-05120234MM14771
PathwayREACTOME_METABOLISM_OF_WATER_SOLUBLE_VITAMINS_AND_COFACTORS

LRP2 ACACA ACACB MMUT

4.87e-05127234M27093
PathwayREACTOME_CHREBP_ACTIVATES_METABOLIC_GENE_EXPRESSION

ACACA ACACB

7.09e-058232M26991
PathwayWP_BIOTIN_METABOLISM_INCLUDING_IMDS

ACACA ACACB

9.10e-059232M40064
PathwayREACTOME_BIOTIN_TRANSPORT_AND_METABOLISM

ACACA ACACB

1.39e-0411232M27086
PathwayREACTOME_BIOTIN_TRANSPORT_AND_METABOLISM

ACACA ACACB

1.39e-0411232MM14764
PathwayREACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS

LRP2 ACACA ACACB MMUT

2.27e-04189234MM14772
PathwayREACTOME_CARNITINE_METABOLISM

ACACA ACACB

2.29e-0414232M27098
PathwayREACTOME_CARNITINE_METABOLISM

ACACA ACACB

2.29e-0414232MM14788
PathwayREACTOME_COBALAMIN_CBL_VITAMIN_B12_TRANSPORT_AND_METABOLISM

LRP2 MMUT

2.64e-0415232MM14762
PathwayREACTOME_METABOLISM_OF_VITAMINS_AND_COFACTORS

LRP2 ACACA ACACB MMUT

2.71e-04198234M18311
PathwayWP_HEREDITARY_LEIOMYOMATOSIS_AND_RENAL_CELL_CARCINOMA_PATHWAY

ACACA ACACB

4.75e-0420232M39751
PathwayWP_FATTY_ACID_BIOSYNTHESIS

ACACA ACACB

5.77e-0422232M39440
PathwayREACTOME_COBALAMIN_CBL_VITAMIN_B12_TRANSPORT_AND_METABOLISM

LRP2 MMUT

5.77e-0422232M27084
PathwayREACTOME_DEFECTS_IN_VITAMIN_AND_COFACTOR_METABOLISM

ACACA MMUT

5.77e-0422232M27243
PathwayWP_FATTY_ACID_BIOSYNTHESIS

ACACA ACACB

6.31e-0423232MM15885
PathwayREACTOME_INTEGRATION_OF_ENERGY_METABOLISM

ACACA ACACB ADCY2

6.93e-04108233M17034
PathwayREACTOME_METABOLISM_OF_LIPIDS

LRP2 PLEKHA5 ACACA ACACB MBOAT7 MMUT

1.08e-03757236M27451
PathwayKEGG_PYRUVATE_METABOLISM

ACACA ACACB

1.91e-0340232M7934
PathwayREACTOME_METABOLISM_OF_STEROIDS

LRP2 ACACA ACACB

1.93e-03154233M27832
PathwayREACTOME_ACTIVATION_OF_GENE_EXPRESSION_BY_SREBF_SREBP

ACACA ACACB

2.11e-0342232M27172
PathwayREACTOME_FATTY_ACID_METABOLISM

ACACA ACACB MMUT

2.56e-03170233MM15573
PathwayREACTOME_METABOLISM_OF_LIPIDS

PLEKHA5 ACACA ACACB MBOAT7 MMUT

2.82e-03620235MM15193
PathwayREACTOME_FATTY_ACID_METABOLISM

ACACA ACACB MMUT

2.82e-03176233M27854
PathwayWP_VITAMIN_B12_METABOLISM

LRP2 MMUT

3.46e-0354232M39337
PathwayREACTOME_REGULATION_OF_CHOLESTEROL_BIOSYNTHESIS_BY_SREBP_SREBF

ACACA ACACB

3.59e-0355232M27001
Pubmed

De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells.

ACACA ACACB

9.28e-07234225282359
Pubmed

Acetyl-CoA carboxylase rewires cancer metabolism to allow cancer cells to survive inhibition of the Warburg effect by cetuximab.

ACACA ACACB

9.28e-07234227693630
Pubmed

AMPK signaling to acetyl-CoA carboxylase is required for fasting- and cold-induced appetite but not thermogenesis.

ACACA ACACB

9.28e-07234229433631
Pubmed

Effects of PKB/Akt inhibitors on insulin-stimulated lipogenesis and phosphorylation state of lipogenic enzymes in white adipose tissue.

ACACA ACACB

9.28e-07234232215608
Pubmed

Activity and structure of human acetyl-CoA carboxylase targeted by a specific inhibitor.

ACACA ACACB

9.28e-07234229772612
Pubmed

Phosphorylation of Acetyl-CoA Carboxylase by AMPK Reduces Renal Fibrosis and Is Essential for the Anti-Fibrotic Effect of Metformin.

ACACA ACACB

9.28e-07234229976587
Pubmed

Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation.

ACACA ACACB

9.28e-07234224944901
Pubmed

Blocking AMPK signalling to acetyl-CoA carboxylase increases cisplatin-induced acute kidney injury and suppresses the benefit of metformin.

ACACA ACACB

9.28e-07234236076520
Pubmed

AMPK-dependent inhibitory phosphorylation of ACC is not essential for maintaining myocardial fatty acid oxidation.

ACACA ACACB

9.28e-07234225001074
Pubmed

Structure and regulation of acetyl-CoA carboxylase genes of metazoa.

ACACA ACACB

9.28e-07234215749055
Pubmed

Angelman syndrome protein UBE3A interacts with primary microcephaly protein ASPM, localizes to centrosomes and regulates chromosome segregation.

ASPM UBE3A

9.28e-07234221633703
Pubmed

The subcellular localization of acetyl-CoA carboxylase 2.

ACACA ACACB

9.28e-07234210677481
Pubmed

Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival.

ACACA ACACB

9.28e-07234228290443
Pubmed

Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma.

ACACA ACACB

9.28e-07234230244972
Pubmed

Hormonal regulation of acetyl-CoA carboxylase isoenzyme gene transcription.

ACACA ACACB

9.28e-07234220139635
Pubmed

Inhibition of Acetyl-CoA Carboxylase 1 (ACC1) and 2 (ACC2) Reduces Proliferation and De Novo Lipogenesis of EGFRvIII Human Glioblastoma Cells.

ACACA ACACB

9.28e-07234228081256
Pubmed

Susceptibility of podocytes to palmitic acid is regulated by fatty acid oxidation and inversely depends on acetyl-CoA carboxylases 1 and 2.

ACACA ACACB

9.28e-07234224338821
Pubmed

Acetyl-CoA carboxylase inhibition by ND-630 reduces hepatic steatosis, improves insulin sensitivity, and modulates dyslipidemia in rats.

ACACA ACACB

9.28e-07234226976583
Pubmed

Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.

ACACA ACACB

2.78e-06334228877461
Pubmed

AMPK activation by SC4 inhibits noradrenaline-induced lipolysis and insulin-stimulated lipogenesis in white adipose tissue.

ACACA ACACB

2.78e-06334234668531
Pubmed

Induced polymerization of mammalian acetyl-CoA carboxylase by MIG12 provides a tertiary level of regulation of fatty acid synthesis.

ACACA ACACB

2.78e-06334220457939
Pubmed

AMPK-ACC signaling modulates platelet phospholipids and potentiates thrombus formation.

ACACA ACACB

2.78e-06334230018077
Pubmed

Macrophage acetyl-CoA carboxylase regulates acute inflammation through control of glucose and lipid metabolism.

ACACA ACACB

2.78e-06334236417534
Pubmed

Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas.

ACACA ACACB

2.78e-06334217521700
Pubmed

Differential activation of recombinant human acetyl-CoA carboxylases 1 and 2 by citrate.

ACACA ACACB

2.78e-06334218455495
Pubmed

Acetyl-CoA carboxylase 1 and 2 inhibition ameliorates steatosis and hepatic fibrosis in a MC4R knockout murine model of nonalcoholic steatohepatitis.

ACACA ACACB

2.78e-06334231990961
Pubmed

The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels.

ACACA ACACB

2.78e-06334227381369
Pubmed

Hepatic de novo lipogenesis is present in liver-specific ACC1-deficient mice.

ACACA ACACB

2.78e-06334217210641
Pubmed

Acetyl-coenzyme A carboxylase alpha gene variations may be associated with the direct effects of some antipsychotics on triglyceride levels.

ACACA ACACB

2.78e-06334219846279
Pubmed

Exploring genetic variations that may be associated with the direct effects of some antipsychotics on lipid levels.

ACACA ACACB

2.78e-06334218031993
Pubmed

Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.

ACACA ACACB

2.78e-06334228768177
Pubmed

PROTAC-mediated degradation reveals a non-catalytic function of AURORA-A kinase.

ASPM MSANTD4 ACACA SP110 USP9X

4.08e-0624734532989298
Pubmed

Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.

ACACA ACACB

5.56e-06434224185692
Pubmed

Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability.

ACACA ACACB

5.56e-06434238447582
Pubmed

Crystal structure of Spot 14, a modulator of fatty acid synthesis.

ACACA ACACB

5.56e-06434220952656
Pubmed

Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program.

ACACA ACACB

9.26e-06534237163372
Pubmed

Metformin-induced increases in GDF15 are important for suppressing appetite and promoting weight loss.

ACACA ACACB

9.26e-06534232694673
Pubmed

TRB3 links the E3 ubiquitin ligase COP1 to lipid metabolism.

ACACA ACACB

9.26e-06534216794074
Pubmed

The AMPK-HOXB9-KRAS axis regulates lung adenocarcinoma growth in response to cellular energy alterations.

ACACA ACACB

2.59e-05834236001969
Pubmed

SIRT1 regulates Tat-induced HIV-1 transactivation through activating AMP-activated protein kinase.

ACACA ACACB

4.15e-051034219720090
Pubmed

Proximity-dependent biotin identification (BioID) reveals a dynamic LSD1-CoREST interactome during embryonic stem cell differentiation.

KIAA1671 LRP2 PLEKHA5 ACACA ACACB

5.11e-0541834534709266
Pubmed

HDAC1/NFκB pathway is involved in curcumin inhibiting of Tat-mediated long terminal repeat transactivation.

ACACA ACACB

6.08e-051234221344388
Pubmed

AMP-activated protein kinase (AMPK) activity is not required for neuronal development but regulates axogenesis during metabolic stress.

ACACA ACACB

6.08e-051234221436046
Pubmed

Ischemic stroke is associated with the ABO locus: the EuroCLOT study.

ASPM ABO

8.38e-051434223381943
Pubmed

IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration.

ACACA USP9X

9.66e-051534218303054
Pubmed

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.

PLEKHA5 ZFR ACACA ACACB USP9X

1.15e-0449734536774506
Pubmed

Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes.

ASPM ZNF622 MBOAT7 USP9X WASF3

1.60e-0453334525544563
Pubmed

SRCAP complex promotes lung cancer progression by reprograming the oncogenic transcription of Hippo-YAP/TAZ signaling pathway.

KIAA1671 PLEKHA5 ZFR ACACA USP9X

1.83e-0454934538280479
Pubmed

AMP-activated protein kinase phosphorylates retinoblastoma protein to control mammalian brain development.

ACACA ACACB

1.93e-042134219217427
Pubmed

Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC).

ACACA ACACB

2.12e-042234220965718
Pubmed

ATP-citrate lyase deficiency in the mouse.

ACACA ACACB

2.32e-042334214662765
Pubmed

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.

LRP2 PLEKHA5 PNMA1 ACACA UBE3A

2.94e-0460834516713569
Pubmed

TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile.

ACACB MBOAT7 UBE3A ADCY2 USP9X

3.66e-0463834531182584
Pubmed

WWP2 is an E3 ubiquitin ligase for PTEN.

ACACA ACACB

3.70e-042934221532586
Pubmed

Electrostatic and steric effects underlie acetylation-induced changes in ubiquitin structure and function.

UBE3A USP9X

4.24e-043134236114200
Pubmed

Complementary proteomics strategies capture an ataxin-1 interactome in Neuro-2a cells.

ZFR ACACA ACACB UBE3A USP9X

4.43e-0466534530457570
Pubmed

Inceptor counteracts insulin signalling in β-cells to control glycaemia.

ACACA ACACB

5.10e-043434233505018
Pubmed

LKB1 deletion causes early changes in atrial channel expression and electrophysiology prior to atrial fibrillation.

ACACA ACACB

5.10e-043434226378152
Pubmed

KAP1 facilitates reinstatement of heterochromatin after DNA replication.

ZNF622 ZFR ACACA MBOAT7 UBE3A

5.73e-0470434529955894
Pubmed

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity.

ASPM KIAA1671 LRP2 PNMA1 SP110 QSOX2

6.71e-04111634631753913
Pubmed

Proteomic analysis of HIV-1 Gag interacting partners using proximity-dependent biotinylation.

ACACA ACACB

7.79e-044234226362536
Pubmed

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.

KIAA1671 PLEKHA5 ACACB USP9X

9.12e-0444634424255178
GeneFamilyPleckstrin homology domain containing|Rho guanine nucleotide exchange factors|C2 domain containing

PLEKHA5 ADAP1

1.40e-02206162682
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Degenerative_Proximal_Tubule_Epithelial_Cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KIAA1671 LRP2 PLEKHA5 EYA2 ACACB

2.97e-071873453ae3b8de1a195d4d5057cf3c64fcdb5f48681ce5
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KIAA1671 LRP2 PLEKHA5 EYA2

1.32e-051913443c464645d0e7e423f791bd63bf5bcf11f6b590d3
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KIAA1671 LRP2 PLEKHA5 EYA2

1.32e-051913441c1d13144259b998d4a0e85142f7afef2ef1e63f
ToppCellMacroglial-Astrocytes-SLC14A1|Macroglial / cells hierarchy compared to all cells using T-Statistic

KIAA1671 EYA2 ACACB ADCY2

1.58e-0520034416f468217427921fa18c6d078ffa990eb019b257
ToppCellMacroglial-Astrocytes|Macroglial / cells hierarchy compared to all cells using T-Statistic

KIAA1671 EYA2 ACACB ADCY2

1.58e-05200344941536b7c32f1e63c70535233b2ccce0cd7bf96e
ToppCellMacroglial-Astrocytes-SLC14A1---|Macroglial / cells hierarchy compared to all cells using T-Statistic

KIAA1671 EYA2 ACACB ADCY2

1.58e-05200344d6fcbf4f4bc1b89a9929d7b114c6b907b6979900
ToppCellMacroglial-Astrocytes-SLC14A1----L1-6|Macroglial / cells hierarchy compared to all cells using T-Statistic

KIAA1671 EYA2 ACACB ADCY2

1.58e-05200344f861509b54185d89931db64da1b9d81986cc7938
ToppCellMacroglial-Astrocytes-SLC14A1--|Macroglial / cells hierarchy compared to all cells using T-Statistic

KIAA1671 EYA2 ACACB ADCY2

1.58e-052003440442894c39eec69850c090957a5dc7bcecd21e04
ToppCellMacroglial-Astrocytes-SLC14A1-|Macroglial / cells hierarchy compared to all cells using T-Statistic

KIAA1671 EYA2 ACACB ADCY2

1.58e-0520034401819446deeab9054f5cfe889d53bb49d137dbc0
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Oligoastrocytoma-9|TCGA-Brain / Sample_Type by Project: Shred V9

KIAA1671 PLEKHA5 ADCY2

1.44e-041343432647453f44b0e0a8f27ef9bba750e99eb40efc8b
ToppCellrenal_cortex_nuclei-Adult_normal_reference-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell_cycling-Cycling_Proximal_Tubule_Epithelial_Cell_low-phase|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

ASPM VWA3A THOP1

1.98e-04149343a6406c4c9404271a2f4c615c6cd3265b2d759b12
ToppCellrenal_papilla_nuclei-Adult_normal_reference-Epithelial-Collecting_tubule_epithelial_cell-kidney_collecting_duct_principal_cell-Cortical_Collecting_Duct_Principal_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

LRP2 ACACB FAM20A

2.05e-04151343f4f7156b2c0cfc78fd1841e07c9915d97ced561f
ToppCellPND01-03-samps-Myeloid-Macrophage-macrophage-B|PND01-03-samps / Age Group, Lineage, Cell class and subclass

ASPM ODAD3 WASF3

2.09e-041523435ce8920aedd39a4daf7082153b5e213707c14227
ToppCellMS-CD4-antiviral_CD4|MS / Condition, Cell_class and T cell subcluster

VWA3A ABO SP110

2.09e-04152343b1eba2d5a6da3eeb83d40a92976e3e8751ed18ee
ToppCellLPS_only-Epithelial_airway-Ciliated_cells|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAJC12 ADCY2 ODAD3

2.18e-0415434358072ce422d09f2de602580325eaac6c4ec6c136
ToppCellLPS_only-Epithelial_airway-Ciliated_cells-Ciliated|LPS_only / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

DNAJC12 ADCY2 ODAD3

2.18e-041543439ca71d440c4f87781e6525b8141e7d8d470b6a8e
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

VWA3A LRP2 MSANTD4

2.35e-04158343e7db0ee4740e3c7a4d97d7cd7462e2c2ab458a4b
ToppCellrenal_medulla_nuclei-Adult_normal_reference-Epithelial-Renal_corpuscle_epithelial_cell-parietal_epithelial_cell-Parietal_Epithelial_Cell|Adult_normal_reference / Celltypes from Cells and Nuclei per compartment and clinical group

VWA3A LRP2 MSANTD4

2.35e-04158343d39e020c3e77eb9d3de600a171d22f94357061d4
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-precursor_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWA3A LRP2 ADCY2

2.44e-04160343c381ec6be8cf887861cc18f831a20db42f953fe1
ToppCellfacs-Marrow-B-cells-24m-Lymphocytic-pre_B_cell|Marrow / Spleen_Marrow_Thymus - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWA3A LRP2 ADCY2

2.44e-0416034325c8f3d2a6d14ff0ca0b965fce89d3ff22f40585
ToppCell3'-Distal_airway-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.0.1.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

KIAA1671 EYA2 ABO

2.44e-04160343445cef1f2f3279672620664792d4eec54df71bdb
ToppCell5'-Adult-SmallIntestine-Epithelial-goblet-BEST2+_Goblet_cell|Adult / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DNAJC12 THOP1 PCGF5

2.71e-041663430b4e1d879c61be9d18d7aac51e5115f103f51209
ToppCellTCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-9|TCGA-Brain / Sample_Type by Project: Shred V9

KIAA1671 PLEKHA5 ADCY2

2.76e-04167343013971700e80b71e4b8c79b8fff0d8beeac295c3
ToppCellPND07-Immune-Immune_Lymphocytic_T/NK-Lymphocytic_ILC-NK-ILC-ILC_G2M|PND07 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

ASPM EYA2 VPS8

2.81e-04168343a7eb28e15b591997f1aee09501cb20ae18beca08
ToppCellE16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWA3A PNMA1 ODAD3

2.81e-04168343fa7c0303918cea04e3f4c4f3cb079be19004d214
ToppCellE16.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|E16.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWA3A PNMA1 ODAD3

2.81e-041683437edcab103c69e928d5c19a0d218ffb3ae32f9e70
ToppCell3'-Parenchyma_lung-Epithelial-Airway_ciliated-ciliated_columnar_cell_of_tracheobronchial_tree-Multiciliated_(non-nasal)-Multiciliated_(non-nasal)_L.0.3.2.1|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

VWA3A EGFL8 ODAD3

2.96e-041713431854a777d9eb9d3fc3ed3632332a6f89ce8131da
ToppCellBac-SEP-Myeloid-cDC1|Bac-SEP / Disease, Lineage and Cell Type

PLEKHA5 PNMA1 WASF3

3.06e-04173343f88269327441858ddb8c49b9dd619b76fd53b1da
ToppCellPrimary_Motor_Cortex_(M1)-Neuronal-Glutamatergic_Excit-Glut_A_(CT)-Glut_CT_L6_FEZF2-Exc_L5-6_FEZF2_ANKRD20A1|Primary_Motor_Cortex_(M1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

KIAA1671 VWA3A ABO

3.11e-0417434399eb5e1aee136c7039e23b68a43a0fa3d775859f
ToppCellHealthy_donor-Plasmablast|World / disease group, cell group and cell class (v2)

ASPM VWA3A EYA2

3.17e-041753435293e00fda63a291aa393bdf82ebd4b80265049f
ToppCellPCW_05-06-Neuronal-Neuronal_SCP-neuro_pre_proliferating_SCP_(4)|PCW_05-06 / Celltypes from embryonic and fetal-stage human lung

LRP2 ADAP1 EGFL8

3.27e-0417734359726bfd98f656fdcedf448a7e2e76a9bfad8285
ToppCellHealthy_donor-Plasmablast|Healthy_donor / disease group, cell group and cell class (v2)

ASPM VWA3A EYA2

3.33e-04178343388b8b4fa20dcc6e9ae4b06118e20b2c20c52bde
ToppCell5'-GW_trimst-2-LargeIntestine-Epithelial-neuro-epithelial-EC_cells_(TAC1+)|GW_trimst-2 / Celltypes from developing, pediatric, Crohn's, & adult GI tract

DNAJC12 EYA2 ABO

3.38e-04179343d70791d2a0db35a6b013fa7ed2f9f39364581eff
ToppCelldroplet-Kidney-nan-21m-Epithelial-Pecam____Kidney_cortex_artery_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

EGFL8 ADCY2 WASF3

3.38e-04179343b7281160c84dd053a2981c9c76ea6cc6d2592cd5
ToppCellControl-Epithelial_cells-AT2|Control / group, cell type (main and fine annotations)

LRP2 ACACA FAM20A

3.44e-04180343198b19e7910b4a8cc7e820c525ab357c7f99f578
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-kidney_proximal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP2 DNAJC12 ODAD3

3.61e-0418334392f54c267135cb5edbcacd26a0f29e62469bb7e5
ToppCelldroplet-Kidney-KIDNEY-30m-Epithelial-Epcam____kidney_proximal_convoluted_tubule_epithelial_cell|Kidney / Skin_Bladder_Kidney_Mammary_Gland - method, tissue, subtissue, age, lineage, cell ontology and free annotation

LRP2 DNAJC12 ODAD3

3.61e-041833435c4f7d02ba3a3c4a22ac71302e7c9a47e205eef5
ToppCellE18.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWA3A PNMA1 ODAD3

3.67e-04184343797b6a6d6f6aafae98f75ca8bffe8263f8d3ff9b
ToppCellE18.5-Epithelial-Epithelial_Airway-Ciliated/Deuterosomal-Ciliated-Ciliated_mature|E18.5 / Age_group by Lineage, Lineage_subclass, Cell_type, subtypes-by-prolif

VWA3A PNMA1 ODAD3

3.67e-0418434377d5b60a20b277f589b18f7a131142a7ef2dac17
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_1_/_Segment_2|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

LRP2 PLEKHA5 EYA2

3.79e-041863435784d255e9ca449d375d81938d0fbbd8a7eb44f6
ToppCellrenal_cortex_nuclei-CKD+DKD_normotensive-Epithelial-Proximal_tubule_epithelial_cell-kidney_proximal_tubule_epithelial_cell-Proximal_Tubule_Epithelial_Cell_Segment_3|CKD+DKD_normotensive / Celltypes from Cells and Nuclei per compartment and clinical group

KIAA1671 LRP2 ADCY2

3.79e-04186343b1edc341d6684b347dc9e21b34f62f51d095d735
ToppCellRA-11._Adipocyte|World / Chamber and Cluster_Paper

EYA2 ACACA ACACB

3.91e-041883434dac9d636e5cad4cda540b93d4bfed6b5732c880
ToppCellfacs-Trachea-24m-Mesenchymal-myofibroblast-tracheobronchial_smooth_muscle_cell-smooth_muscle_cell_of_trachea_l32-30|24m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

ADAP1 ACACA EGFL8

3.91e-04188343c2febf9fd4632af1f922067c3a30e5c50f75f480
ToppCellRV-06._Ventricular_Cardiomyocyte_II|World / Chamber and Cluster_Paper

FSD2 PLEKHA5 ACACB

3.97e-041893435e80c47f63980904c4c1ff02c201b67b456a0974
ToppCellAdult|World / Lineage, Cell type, age group and donor

LRP2 ABO FAM20A

3.97e-041893435cd285bfad973125d46d704fec18b21266a63379
ToppCellfacs-Lung-18m-Epithelial-airway_epithelial-lung_ciliated_cell-ciliated_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWA3A FSD2 ODAD3

4.03e-041903439ffd18ef358f8e32c610ab6420f479067c8ba44b
ToppCellSomatosensory_Cortex_(S1)-Non-neuronal-Macroglial|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

LRP2 EYA2 ACACB

4.03e-0419034307f21386ea6eb23416a537d2250e3042efe93fb0
ToppCellLV-06._Ventricular_Cardiomyocyte_II|World / Chamber and Cluster_Paper

FSD2 PLEKHA5 ACACB

4.03e-04190343de5ef606a002f85c2e0e3a36c1f259d0b85a76ff
ToppCellfacs-Lung-18m-Epithelial-airway_epithelial-lung_ciliated_cell|18m / method, tissue, age, lineage, sublineage, cell ontologies, cell type and subtype

VWA3A FSD2 ODAD3

4.03e-041903433ef39d61c98de4e5df946b995847aa65eba6a4b6
ToppCellfacs-Lung-nan-3m-Epithelial-Ciliated_cell|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWA3A FSD2 PNMA1

4.03e-04190343e243b5fbb17b9ec3cc90bbe970c1d30b0fd1c2e1
ToppCellfacs-Lung-nan-3m-Epithelial-ciliated_columnar_cell_of_tracheobronchial_tree|Lung / Lung_Trachea - method, tissue, subtissue, age, lineage, cell ontology and free annotation

VWA3A FSD2 PNMA1

4.03e-04190343fe844559b95832845d2e8d3ab4b57e3d558bc372
ToppCellLPS-IL1RA-Endothelial-Endothelial-Alv_Gen_Intermediate|LPS-IL1RA / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2

KIAA1671 ABO ACACB

4.03e-04190343106ea0bb7b99c697ffc5443d72343df2484250c7
ToppCellRV-06._Ventricular_Cardiomyocyte_II|RV / Chamber and Cluster_Paper

FSD2 PLEKHA5 ACACB

4.03e-04190343fe8e78922c8ae928ef9a80bffd67868d5a87a091
ToppCellLV-06._Ventricular_Cardiomyocyte_II|LV / Chamber and Cluster_Paper

FSD2 PLEKHA5 ACACB

4.09e-0419134325f3eb34f4e70761e81e84c8a5829f216108cbc6
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2-D122|Adult / Lineage, Cell type, age group and donor

LRP2 ACACA FAM20A

4.15e-0419234306013a07e3a873b1d1c0451643c528593ac32a9c
ToppCellAdult-Epithelial-alveolar_epithelial_cell_type_2|Adult / Lineage, Cell type, age group and donor

LRP2 ACACA FAM20A

4.22e-04193343738f4f0a9ddde2432b429ab46838e353b1790589
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

LRP2 ACACA FAM20A

4.22e-04193343fd4d3c0d7caf8a2fff5b3d901fc28d19a8163cdf
ToppCellLA|World / Chamber and Cluster_Paper

LRP2 EYA2 WASF3

4.22e-04193343d4bf89437216baf489ea0239136dcedf3b6714af
ToppCellnucseq-Epithelial-Epithelial_Alveolar-AT2|nucseq / Celltype signatures by Technology, Lineage, Lineage_subclass, Celltype_group, Cell_type2

LRP2 ACACA FAM20A

4.22e-04193343f3cc7cfdbc164a4ed42f87647111522b7d393bcb
ToppCell3'-Broncho-tracheal-Epithelial-Airway_epithelium-respiratory_basal_cell-Suprabasal-Suprabasal_L.0.4.4.2|3' / 5'-vs-3', Tissue groups, Lineages, Lineage subclass, Cell_type2, Cell_subtype2_L4.5

DNAJC12 PLEKHA5 ABO

4.28e-0419434340251e6415a62fa55d86f2e8609bf0402e1c1abb
ToppCellIPF-Epithelial|IPF / Disease state, Lineage and Cell class

VWA3A PLEKHA5 EYA2

4.41e-0419634387d9881cfec461a5d89b688a83749b618c519485
ToppCellNeuron-Postmitotic-Excitatory_Neuron_-Deep_Layer|World / Primary Cells by Cluster

DNAJC12 PNMA1 EYA2

4.48e-0419734341e823b14697827f657b13adb3afa581bd91a9cb
ToppCellCOVID-19_Severe-PLT_0|COVID-19_Severe / Disease Group and Platelet Clusters

PNMA1 WASF3 VPS8

4.48e-04197343dbdeefa72d10f2c5f75ad5aac6f31a892d4e94a9
ToppCellParenchymal-NucSeq-Epithelial-Epi_alveolar-AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

LRP2 ACACA FAM20A

4.54e-041983432e2a4e1756bba6f4fbe529559a97d2993c890b4b
ToppCellSomatosensory_Cortex_(S1)-Neuronal|Somatosensory_Cortex_(S1) / Sample groups (6 Anatomical region groups), with 5 level hierarchy of cell types

PLEKHA5 UBE3A ADCY2

4.54e-04198343c01091ef18e096d792ea2a7a715764a5b215355f
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar-AT2|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

LRP2 ACACA FAM20A

4.54e-04198343f948391296c261c473d339069a6d0f20ccd6f38f
ToppCellBronchial-NucSeq-Epithelial-Epi_alveolar|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

LRP2 ACACA FAM20A

4.61e-04199343725610310e5c5fd7120c0be9acb55bf152026ddd
ToppCellSepsis-Bac-SEP-Myeloid-cDC1|Bac-SEP / Disease, condition lineage and cell class

PLEKHA5 PNMA1 WASF3

4.68e-04200343cd381644fd8b8674a017d267bfbb00f2668294ae
ToppCellTracheal|World / Cell types per location group and 10X technology with lineage, and cell group designations

PLEKHA5 EYA2 ADCY2

4.68e-04200343682960e28542a3d6c119047cd0131941932cfdea
ToppCellTracheal-NucSeq-Epithelial|NucSeq / Cell types per location group and 10X technology with lineage, and cell group designations

KIAA1671 ABO ACACA

4.68e-04200343d3af0a706baf66e3f32e67b17dcfc31e5b32ce0e
ToppCellBrain_organoid-organoid_Tanaka_cellReport-1m-Mesenchymal-Mesoderm|1m / Sample Type, Dataset, Time_group, and Cell type.

ZNF622 ACACB MMUT

4.68e-04200343c0ad32e9dd7f481c2665587fd8bd9fffc2e725f9
ToppCellParenchymal-10x3prime_v2-Epithelial-Epi_alveolar-Dividing_AT2|10x3prime_v2 / Cell types per location group and 10X technology with lineage, and cell group designations

LRP2 FAM20A WASF3

4.68e-04200343befc25cbcbac2c02e5fd33d6e78e59979050090c
DrugAC1NR4P4

ABO ACACA

2.16e-062342CID005284567
Diseasesulfhydryl oxidase 2 measurement

ABO QSOX2

7.27e-064332EFO_0802100
Diseasemuscular disease (implicated_via_orthology)

ACACA ACACB

1.21e-055332DOID:0080000 (implicated_via_orthology)
Diseasecoagulation factor measurement

ASPM ABO

2.28e-0420332EFO_0004634
Diseasefatty liver disease (implicated_via_orthology)

ACACA ACACB

5.53e-0431332DOID:9452 (implicated_via_orthology)

Protein segments in the cluster

PeptideGeneStartEntry
TMYRVMWREVRREVQ

EGFL8

76

Q99944
RAYKRWQDVSMRRME

ABO

176

P16442
SRARYDHWRRSQMSM

DNAJC12

71

Q9UKB3
VKCMRSIRRWSYEMF

ACACA

131

Q13085
SVRSMVMRYGSRLWK

ACACA

1491

Q13085
RKRWFTMDDRRLMYF

ADAP1

271

O75689
SYRRWMIRKRMREMH

ASPM

2321

Q8IZT6
MVMYFFFRVRSRRWK

QSOX2

676

Q6ZRP7
MRSIRRWAYEMFRNE

ACACB

276

O00763
TMEFIYMTRWRLRGE

PCGF5

206

Q86SE9
TWLMETKDRRQRYRS

LEXM

361

Q3ZCV2
KAGAMDQRMDRWRRR

KIAA1671

936

Q9BY89
RKLRKIEWMRQMYYS

MFI

176

Q8NCR3
WQQYRSVRRERLKEM

FAM9B

141

Q8IZU0
VRVRDGMRYWNMTVQ

MBOAT7

311

Q96N66
YWTDRATRRVMRANK

LRP2

1656

P98164
MWQEAMRRRRYLRDR

ADCY2

1

Q08462
VSYRMLGRMFWREEN

PNMA1

46

Q8ND90
WMRKLAFRYRRVKEM

EYA2

376

O00167
DHMMKRMSYRRQKRW

USP9X

1931

Q93008
AKEEELRQRWSMYQM

ODAD3

341

A5D8V7
ARWNRRHKMYREQMN

FAM20A

131

Q96MK3
YMMKRRDPAREQRDW

FSD2

106

A1L4K1
SVYVMMLRSWRERVD

VPS8

491

Q8N3P4
YTVAWFVRDMRLMFR

SP110

631

Q9HB58
RRYLDWRALMKRKRM

MSANTD4

71

Q8NCY6
KNLYRDVMWETMRNL

ZNF136

26

P52737
RLWSKYNADQIRRMM

UBE3A

326

Q05086
RKARNRRQEWNMMAY

WASF3

196

Q9UPY6
RRQEWNMMAYDKELR

WASF3

201

Q9UPY6
ASRTSRMWDAVLYRM

PRR33

246

A8MZF0
MRKQMQKEEYWRRRE

ZFR

636

Q96KR1
RMEMRRYEEDMYWRR

ZFR

656

Q96KR1
RERDMQYVQRMKSKW

ZNF622

441

Q969S3
KRRSMRDDTMWQLYE

PLEKHA5

491

Q9HAU0
YTTRRDSVLQMWRGM

TMEM177

291

Q53S58
RIRAWDMRYYMNQVE

THOP1

331

P52888
QLSRAMRMYERRIEW

VWA3A

481

A6NCI4
MRMYERRIEWLSLAS

VWA3A

486

A6NCI4
YMEIAKMRAGRRLWA

MMUT

316

P22033