Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	IkappaB kinase activity	IKBKE IKBKB CHUK	6.43e-08	3	81	3	GO:0008384
GeneOntologyMolecularFunction	minus-end-directed microtubule motor activity	DNAH12 DNAH17 DNAH14 DNAH1	7.36e-07	18	81	4	GO:0008569
GeneOntologyMolecularFunction	dynein light intermediate chain binding	DNAH12 DNAH17 DNAH14 DNAH1	4.78e-06	28	81	4	GO:0051959
GeneOntologyMolecularFunction	microtubule motor activity	DNAH12 DNAH17 KIF28P DNAH14 DNAH1	9.54e-06	70	81	5	GO:0003777
GeneOntologyMolecularFunction	dynein intermediate chain binding	DNAH12 DNAH17 DNAH14 DNAH1	1.50e-05	37	81	4	GO:0045505
GeneOntologyMolecularFunction	cytoskeletal motor activity	DNAH12 DNAH17 KIF28P DNAH14 DNAH1	1.19e-04	118	81	5	GO:0003774
GeneOntologyMolecularFunction	glycerol-3-phosphate O-acyltransferase activity	GPAT3 GPAT4	1.61e-04	5	81	2	GO:0004366
GeneOntologyMolecularFunction	transferrin receptor binding	IKBKB CHUK	8.73e-04	11	81	2	GO:1990459
GeneOntologyCellularComponent	dynein complex	DNAH12 DNAH17 DNAH14 DNAH1	6.28e-05	54	83	4	GO:0030286
GeneOntologyCellularComponent	transferase complex	RTF1 CCNE1 FBXO48 RGPD2 KMT2D KANSL1 RB1 IKBKE POLE DEPDC5 IKBKB FBXL5 CHUK	1.03e-04	963	83	13	GO:1990234
GeneOntologyCellularComponent	axonemal dynein complex	DNAH12 DNAH17 DNAH1	1.30e-04	25	83	3	GO:0005858
GeneOntologyCellularComponent	transferase complex, transferring phosphorus-containing groups	RTF1 CCNE1 RB1 IKBKE POLE IKBKB CHUK	3.73e-04	335	83	7	GO:0061695
GeneOntologyCellularComponent	serine/threonine protein kinase complex	CCNE1 RB1 IKBKE IKBKB CHUK	4.06e-04	157	83	5	GO:1902554
GeneOntologyCellularComponent	IkappaB kinase complex	IKBKB CHUK	4.29e-04	8	83	2	GO:0008385
GeneOntologyCellularComponent	microtubule associated complex	DNAH12 DNAH17 KIF28P DNAH14 DNAH1	4.56e-04	161	83	5	GO:0005875
GeneOntologyCellularComponent	protein kinase complex	CCNE1 RB1 IKBKE IKBKB CHUK	5.84e-04	170	83	5	GO:1902911
GeneOntologyCellularComponent	inner dynein arm	DNAH12 DNAH1	6.87e-04	10	83	2	GO:0036156
GeneOntologyCellularComponent	CD40 receptor complex	IKBKB CHUK	8.37e-04	11	83	2	GO:0035631
GeneOntologyCellularComponent	microtubule	DNAH12 DCDC2C IQGAP2 DNAH17 KIF28P DNAH14 WDR44 DNAH1	1.25e-03	533	83	8	GO:0005874
MousePheno	abnormal mammary gland physiology	CCNE1 ERBB3 KALRN RB1 GPAT4 CHUK	5.87e-06	88	72	6	MP:0001881
MousePheno	abnormal apocrine gland physiology	CCNE1 ERBB3 KALRN RB1 GPAT4 CHUK	5.87e-06	88	72	6	MP:0013555
MousePheno	abnormal lactation	ERBB3 KALRN RB1 GPAT4 CHUK	3.37e-05	72	72	5	MP:0001882
Domain	IKKbetaNEMObind	IKBKB CHUK	1.77e-05	2	79	2	IPR022007
Domain	IKKbetaNEMObind	IKBKB CHUK	1.77e-05	2	79	2	PF12179
Domain	IKKbetaNEMObind	IKBKB CHUK	1.77e-05	2	79	2	SM01239
Domain	Dynein_heavy_chain_D4_dom	DNAH12 DNAH14 DNAH1	2.56e-05	14	79	3	IPR024317
Domain	AAA_8	DNAH12 DNAH14 DNAH1	2.56e-05	14	79	3	PF12780
Domain	DHC_fam	DNAH12 DNAH14 DNAH1	3.19e-05	15	79	3	IPR026983
Domain	Dynein_heavy_dom	DNAH12 DNAH14 DNAH1	3.19e-05	15	79	3	IPR004273
Domain	Dynein_heavy	DNAH12 DNAH14 DNAH1	3.19e-05	15	79	3	PF03028
Domain	VPS13	VPS13D VPS13C	5.29e-05	3	79	2	IPR026847
Domain	VPS13_mid_rpt	VPS13D VPS13C	5.29e-05	3	79	2	PF16910
Domain	VPS13	VPS13D VPS13C	5.29e-05	3	79	2	PF16908
Domain	VPS13_N2	VPS13D VPS13C	5.29e-05	3	79	2	IPR031646
Domain	VPS13_mid_rpt	VPS13D VPS13C	5.29e-05	3	79	2	IPR031642
Domain	VPS13_C	VPS13D VPS13C	1.05e-04	4	79	2	PF16909
Domain	SHR-BD	VPS13D VPS13C	1.05e-04	4	79	2	IPR009543
Domain	VPS13_C	VPS13D VPS13C	1.05e-04	4	79	2	IPR031645
Domain	SHR-BD	VPS13D VPS13C	1.05e-04	4	79	2	PF06650
Domain	SEC14	KALRN MCF2L SEC14L1	1.57e-04	25	79	3	SM00516
Domain	CRAL_TRIO	KALRN MCF2L SEC14L1	1.98e-04	27	79	3	PS50191
Domain	CRAL-TRIO_dom	KALRN MCF2L SEC14L1	2.21e-04	28	79	3	IPR001251
Domain	F-box_dom	FBXO48 FBXW10B FBXW10 FBXL5	2.87e-04	75	79	4	IPR001810
Domain	VPS13_N	VPS13D VPS13C	4.87e-04	8	79	2	IPR026854
Domain	Chorein_N	VPS13D VPS13C	4.87e-04	8	79	2	PF12624
Domain	WD_REPEATS_1	NBAS FBXW10B FBXW10 IFT122 RIC1 WDR44	1.15e-03	278	79	6	PS00678
Domain	WD_REPEATS_2	NBAS FBXW10B FBXW10 IFT122 RIC1 WDR44	1.18e-03	279	79	6	PS50082
Domain	WD_REPEATS_REGION	NBAS FBXW10B FBXW10 IFT122 RIC1 WDR44	1.18e-03	279	79	6	PS50294
Domain	Dynein_HC_stalk	DNAH14 DNAH1	1.56e-03	14	79	2	IPR024743
Domain	Dynein_heavy_dom-2	DNAH12 DNAH1	1.56e-03	14	79	2	IPR013602
Domain	DHC_N2	DNAH12 DNAH1	1.56e-03	14	79	2	PF08393
Domain	MT	DNAH14 DNAH1	1.56e-03	14	79	2	PF12777
Domain	ATPase_dyneun-rel_AAA	DNAH12 DNAH1	1.56e-03	14	79	2	IPR011704
Domain	AAA_5	DNAH12 DNAH1	1.56e-03	14	79	2	PF07728
Domain	Acyltransferase	GPAT3 GPAT4	2.04e-03	16	79	2	PF01553
Domain	PlsC	GPAT3 GPAT4	2.31e-03	17	79	2	SM00563
Domain	Plipid/glycerol_acylTrfase	GPAT3 GPAT4	2.31e-03	17	79	2	IPR002123
Domain	-	NBAS FBXW10B FBXW10 IFT122 RIC1 WDR44	2.86e-03	333	79	6	2.130.10.10
Domain	WD40/YVTN_repeat-like_dom	NBAS FBXW10B FBXW10 IFT122 RIC1 WDR44	2.95e-03	335	79	6	IPR015943
Domain	RNaseH-like_dom	ZBED4 POLE REXO1	3.12e-03	69	79	3	IPR012337
Domain	PROTEIN_KINASE_ATP	BMPR1A ERBB3 KALRN IKBKE IKBKB CHUK EPHA7	3.27e-03	459	79	7	PS00107
Domain	CRAL_TRIO	KALRN SEC14L1	3.52e-03	21	79	2	PF00650
Domain	FBOX	FBXO48 FBXW10 FBXL5	3.52e-03	72	79	3	PS50181
Domain	-	KALRN SEC14L1	4.22e-03	23	79	2	3.40.525.10
Domain	Spectrin	KALRN MCF2L	4.22e-03	23	79	2	PF00435
Domain	Prot_kinase_dom	BMPR1A ERBB3 KALRN IKBKE IKBKB CHUK EPHA7	4.62e-03	489	79	7	IPR000719
Domain	PROTEIN_KINASE_DOM	BMPR1A ERBB3 KALRN IKBKE IKBKB CHUK EPHA7	4.83e-03	493	79	7	PS50011
Domain	G-protein_beta_WD-40_rep	FBXW10B FBXW10 WDR44	5.61e-03	85	79	3	IPR020472
Domain	Spectrin_repeat	KALRN MCF2L	6.66e-03	29	79	2	IPR002017
Domain	Kinase-like_dom	BMPR1A ERBB3 KALRN IKBKE IKBKB CHUK EPHA7	7.99e-03	542	79	7	IPR011009
Domain	Spectrin/alpha-actinin	KALRN MCF2L	8.07e-03	32	79	2	IPR018159
Domain	SPEC	KALRN MCF2L	8.07e-03	32	79	2	SM00150
Pathway	BIOCARTA_RACCYCD_PATHWAY	CCNE1 RB1 IKBKB CHUK	3.13e-06	26	56	4	M14512
Pathway	BIOCARTA_RACCYCD_PATHWAY	CCNE1 RB1 IKBKB CHUK	3.13e-06	26	56	4	MM1423
Pathway	WP_STING_PATHWAY_IN_KAWASAKILIKE_DISEASE_AND_COVID19	IKBKE IKBKB CHUK	7.51e-05	21	56	3	M40061
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_SOD1_TO_RETROGRADE_AXONAL_TRANSPORT	DNAH12 DNAH17 DNAH1	1.62e-04	27	56	3	M47755
Pathway	WP_TLR4_SIGNALING_AND_TOLERANCE	IKBKE IKBKB CHUK	1.81e-04	28	56	3	M39561
Pathway	REACTOME_SLC15A4_TASL_DEPENDENT_IRF5_ACTIVATION	IKBKB CHUK	2.30e-04	6	56	2	M48272
Pathway	REACTOME_SLC15A4_TASL_DEPENDENT_IRF5_ACTIVATION	IKBKB CHUK	2.30e-04	6	56	2	MM17244
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_CCNE_TO_CELL_CYCLE_G1_S	CCNE1 RB1	2.30e-04	6	56	2	M47489
Pathway	KEGG_MEDICUS_PATHOGEN_KSHV_VFLIP_TO_NFKB_SIGNALING_PATHWAY	IKBKB CHUK	2.30e-04	6	56	2	M47462
Pathway	REACTOME_DEATH_RECEPTOR_SIGNALING	KALRN IKBKE MCF2L IKBKB CHUK	2.44e-04	142	56	5	MM15431
Pathway	WP_TOLLLIKE_RECEPTOR_SIGNALING_RELATED_TO_MYD88	IKBKE IKBKB CHUK	2.47e-04	31	56	3	M39573
Pathway	WP_TOLLLIKE_RECEPTOR_SIGNALING	IKBKE IKBKB CHUK	2.98e-04	33	56	3	MM15940
Pathway	REACTOME_DDX58_IFIH1_MEDIATED_INDUCTION_OF_INTERFERON_ALPHA_BETA	IKBKE IKBKB CHUK	2.98e-04	33	56	3	MM14666
Pathway	WP_HOSTPATHOGEN_INTERACTION_OF_HUMAN_CORONAVIRUSES_INTERFERON_INDUCTION	IKBKE IKBKB CHUK	2.98e-04	33	56	3	M39909
Pathway	REACTOME_IKBA_VARIANT_LEADS_TO_EDA_ID	IKBKB CHUK	3.21e-04	7	56	2	M27463
Pathway	KEGG_MEDICUS_PATHOGEN_KSHV_VFLIP_TO_TNF_NFKB_SIGNALING_PATHWAY	IKBKB CHUK	3.21e-04	7	56	2	M47464
Pathway	KEGG_MEDICUS_PATHOGEN_HPV_E7_TO_P27_CELL_CYCLE_G1_S	CCNE1 RB1	3.21e-04	7	56	2	M47527
Pathway	KEGG_SMALL_CELL_LUNG_CANCER	CCNE1 RB1 IKBKB CHUK	3.40e-04	84	56	4	M3228
Pathway	REACTOME_DEATH_RECEPTOR_SIGNALING	KALRN IKBKE MCF2L IKBKB CHUK	3.55e-04	154	56	5	M27697
Pathway	KEGG_PROSTATE_CANCER	CCNE1 RB1 IKBKB CHUK	4.24e-04	89	56	4	M13191
Pathway	WP_CANONICAL_NFKB_PATHWAY	IKBKB CHUK	4.27e-04	8	56	2	M39783
Pathway	KEGG_MEDICUS_PATHOGEN_HTLV_1_TAX_TO_P21_CELL_CYCLE_G1_S_N00498	CCNE1 RB1	4.27e-04	8	56	2	M47585
Pathway	KEGG_MEDICUS_VARIANT_LOSS_OF_CDKN1B_TO_P27_CELL_CYCLE_G1_S	CCNE1 RB1	4.27e-04	8	56	2	M47429
Pathway	KEGG_MEDICUS_PATHOGEN_KSHV_K15_TO_TNF_NFKB_SIGNALING_PATHWAY	IKBKB CHUK	4.27e-04	8	56	2	M47463
Pathway	REACTOME_ASSOCIATION_OF_TRIC_CCT_WITH_TARGET_PROTEINS_DURING_BIOSYNTHESIS	CCNE1 FBXW10 FBXL5	4.90e-04	39	56	3	M3871
Pathway	BIOCARTA_FBW7_PATHWAY	CCNE1 RB1	5.48e-04	9	56	2	MM1568
Pathway	BIOCARTA_FBW7_PATHWAY	CCNE1 RB1	5.48e-04	9	56	2	M22053
Pathway	WP_ALTERED_GLYCOSYLATION_OF_MUC1_IN_TUMOR_MICROENVIRONMENT	IKBKB CHUK	5.48e-04	9	56	2	M39757
Pathway	WP_SUPPRESSION_OF_HMGB1MEDIATED_INFLAMMATION_BY_THBD	IKBKB CHUK	5.48e-04	9	56	2	M39509
Pathway	KEGG_MEDICUS_PATHOGEN_HTLV_1_TAX_TO_P21_CELL_CYCLE_G1_S_N00497	CCNE1 RB1	5.48e-04	9	56	2	M47584
Pathway	KEGG_MEDICUS_PATHOGEN_EBV_EBNA3C_TO_P27_CELL_CYCLE_G1_S_N00482	CCNE1 RB1	5.48e-04	9	56	2	M47578
Pathway	KEGG_MEDICUS_REFERENCE_NOD_NFKB_SIGNALING_PATHWAY	IKBKB CHUK	5.48e-04	9	56	2	M47652
Pathway	WP_NODLIKE_RECEPTOR_NLR_SIGNALING	IKBKB CHUK	5.48e-04	9	56	2	M39494
Pathway	WP_NODLIKE_RECEPTOR_NLR_SIGNALING_PATHWAY	IKBKB CHUK	5.48e-04	9	56	2	MM15889
Pathway	KEGG_MEDICUS_PATHOGEN_SALMONELLA_SOPE_E2_TO_NOD_NFKB_SIGNALING_PATHWAY	IKBKB CHUK	5.48e-04	9	56	2	M47734
Pathway	WP_SMALL_CELL_LUNG_CANCER	CCNE1 RB1 IKBKB CHUK	5.66e-04	96	56	4	M39834
Pathway	KEGG_MEDICUS_REFERENCE_RETROGRADE_AXONAL_TRANSPORT	DNAH12 DNAH17 DNAH1	6.55e-04	43	56	3	M47669
Pathway	KEGG_MEDICUS_REFERENCE_LIGHT_HVEM_NFKB_SIGNALING_PATHWAY	IKBKB CHUK	6.83e-04	10	56	2	M47599
Pathway	KEGG_MEDICUS_REFERENCE_TLR3_NFKB_SIGNALING_PATHWAY	IKBKB CHUK	6.83e-04	10	56	2	M47601
Pathway	BIOCARTA_SKP2E2F_PATHWAY	CCNE1 RB1	6.83e-04	10	56	2	MM1384
Pathway	BIOCARTA_SKP2E2F_PATHWAY	CCNE1 RB1	6.83e-04	10	56	2	M6031
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_CAUSED_ABERRANT_HTT_TO_RETROGRADE_AXONAL_TRANSPORT	DNAH12 DNAH17 DNAH1	7.49e-04	45	56	3	M47670
Pathway	KEGG_MEDICUS_REFERENCE_MDM2_P21_CELL_CYCLE_G1_S_N00536	CCNE1 RB1	8.33e-04	11	56	2	M47591
Pathway	KEGG_MEDICUS_PATHOGEN_EBV_EBNA3C_TO_P27_CELL_CYCLE_G1_S_N00264	CCNE1 RB1	8.33e-04	11	56	2	M47492
Pathway	KEGG_MEDICUS_PATHOGEN_EBV_LMP1_TO_NFKB_SIGNALING_PATHWAY	IKBKB CHUK	8.33e-04	11	56	2	M47493
Pathway	REACTOME_REGULATION_OF_TNFR1_SIGNALING	IKBKE IKBKB CHUK	8.51e-04	47	56	3	MM15179
Pathway	WP_MAPK_AND_NFKB_SIGNALING_INHIBITED_BY_YERSINIA_YOPJ	IKBKB CHUK	9.97e-04	12	56	2	M39552
Pathway	KEGG_MEDICUS_PATHOGEN_HSV_GD_TO_HVEM_NFKB_SIGNALING_PATHWAY	IKBKB CHUK	9.97e-04	12	56	2	M47600
Pathway	BIOCARTA_P27_PATHWAY	CCNE1 RB1	9.97e-04	12	56	2	MM1472
Pathway	BIOCARTA_P27_PATHWAY	CCNE1 RB1	1.18e-03	13	56	2	M17977
Pathway	REACTOME_MAP3K8_TPL2_DEPENDENT_MAPK1_3_ACTIVATION	IKBKB CHUK	1.18e-03	13	56	2	MM15280
Pathway	REACTOME_ZBP1_DAI_MEDIATED_INDUCTION_OF_TYPE_I_IFNS	IKBKB CHUK	1.18e-03	13	56	2	MM14616
Pathway	WP_OSTEOPONTIN_SIGNALING	IKBKB CHUK	1.18e-03	13	56	2	M39603
Pathway	REACTOME_NF_KB_ACTIVATION_THROUGH_FADD_RIP_1_PATHWAY_MEDIATED_BY_CASPASE_8_AND_10	IKBKB CHUK	1.18e-03	13	56	2	M957
Pathway	WP_CARDIAC_HYPERTROPHIC_RESPONSE	IKBKE IKBKB CHUK	1.35e-03	55	56	3	M39685
Pathway	KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY	IKBKE IKBKB CHUK	1.35e-03	55	56	3	M11844
Pathway	BIOCARTA_CD40_PATHWAY	IKBKB CHUK	1.37e-03	14	56	2	MM1362
Pathway	KEGG_MEDICUS_PATHOGEN_HIV_NEF_TO_TNF_NFKB_SIGNALING_PATHWAY	IKBKB CHUK	1.37e-03	14	56	2	M47567
Pathway	KEGG_MEDICUS_REFERENCE_P27_CELL_CYCLE_G1_S	CCNE1 RB1	1.37e-03	14	56	2	M47427
Pathway	KEGG_MEDICUS_REFERENCE_IGF_IGFR_PI3K_NFKB_SIGNALING_PATHWAY	IKBKB CHUK	1.37e-03	14	56	2	M47467
Pathway	KEGG_MEDICUS_REFERENCE_EGF_EGFR_PI3K_NFKB_SIGNALING_PATHWAY	IKBKB CHUK	1.37e-03	14	56	2	M47536
Pathway	REACTOME_IRAK1_RECRUITS_IKK_COMPLEX	IKBKB CHUK	1.37e-03	14	56	2	M935
Pathway	REACTOME_TRAF6_MEDIATED_NF_KB_ACTIVATION	IKBKB CHUK	1.37e-03	14	56	2	MM15641
Pathway	REACTOME_TNF_SIGNALING	IKBKE IKBKB CHUK	1.42e-03	56	56	3	MM15453
Pathway	REACTOME_TNF_SIGNALING	IKBKE IKBKB CHUK	1.49e-03	57	56	3	M27713
Pathway	BIOCARTA_RELA_PATHWAY	IKBKB CHUK	1.57e-03	15	56	2	MM1339
Pathway	BIOCARTA_CD40_PATHWAY	IKBKB CHUK	1.57e-03	15	56	2	M16697
Pathway	KEGG_MEDICUS_PATHOGEN_HIV_GP120_TO_TNF_NFKB_SIGNALING_PATHWAY	IKBKB CHUK	1.57e-03	15	56	2	M47566
Pathway	KEGG_MEDICUS_VARIANT_AMPLIFIED_MYC_TO_P27_CELL_CYCLE_G1_S	CCNE1 RB1	1.57e-03	15	56	2	M47428
Pathway	KEGG_MEDICUS_ENV_FACTOR_METALS_TO_NFKB_SIGNALING_PATHWAY	IKBKB CHUK	1.57e-03	15	56	2	M47816
Pathway	BIOCARTA_P53_PATHWAY	CCNE1 RB1	1.57e-03	15	56	2	MM1451
Pathway	BIOCARTA_RELA_PATHWAY	IKBKB CHUK	1.57e-03	15	56	2	M10183
Pathway	REACTOME_IRAK1_RECRUITS_IKK_COMPLEX	IKBKB CHUK	1.57e-03	15	56	2	MM15645
Pathway	WP_NOVEL_INTRACELLULAR_COMPONENTS_OF_RIGILIKE_RECEPTOR_PATHWAY	IKBKE IKBKB CHUK	1.73e-03	60	56	3	M39583
Pathway	WP_ID_SIGNALING	CCNE1 RB1	1.79e-03	16	56	2	M39359
Pathway	REACTOME_MAP3K8_TPL2_DEPENDENT_MAPK1_3_ACTIVATION	IKBKB CHUK	1.79e-03	16	56	2	M27567
Pathway	KEGG_MEDICUS_REFERENCE_TNF_NFKB_SIGNALING_PATHWAY	IKBKB CHUK	1.79e-03	16	56	2	M47453
Pathway	BIOCARTA_P53_PATHWAY	CCNE1 RB1	1.79e-03	16	56	2	M14863
Pathway	WP_G1_TO_S_CELL_CYCLE_CONTROL	CCNE1 RB1 POLE	1.82e-03	61	56	3	MM15912
Pathway	BIOCARTA_TNFR2_PATHWAY	IKBKB CHUK	2.03e-03	17	56	2	M10082
Pathway	BIOCARTA_TNFR2_PATHWAY	IKBKB CHUK	2.03e-03	17	56	2	MM1517
Pathway	REACTOME_REGULATION_OF_NF_KAPPA_B_SIGNALING	IKBKB CHUK	2.03e-03	17	56	2	MM15702
Pathway	REACTOME_ABERRANT_REGULATION_OF_MITOTIC_G1_S_TRANSITION_IN_CANCER_DUE_TO_RB1_DEFECTS	CCNE1 RB1	2.03e-03	17	56	2	M38998
Pathway	REACTOME_RIP_MEDIATED_NFKB_ACTIVATION_VIA_ZBP1	IKBKB CHUK	2.03e-03	17	56	2	M583
Pathway	KEGG_MEDICUS_REFERENCE_TLR5_NFKB_SIGNALING_PATHWAY	IKBKB CHUK	2.03e-03	17	56	2	M47912
Pathway	WP_MEASLES_VIRUS_INFECTION	CCNE1 IKBKE IKBKB CHUK	2.06e-03	136	56	4	M42547
Pathway	WP_G1_TO_S_CELL_CYCLE_CONTROL	CCNE1 RB1 POLE	2.08e-03	64	56	3	M39627
Pathway	BIOCARTA_41BB_PATHWAY	IKBKB CHUK	2.28e-03	18	56	2	M2064
Pathway	BIOCARTA_41BB_PATHWAY	IKBKB CHUK	2.28e-03	18	56	2	MM1511
Pathway	REACTOME_REGULATION_OF_NF_KAPPA_B_SIGNALING	IKBKB CHUK	2.28e-03	18	56	2	M45023
Pathway	WP_RAC1PAK1P38MMP2_PATHWAY	IKBKB RS1 CHUK	2.48e-03	68	56	3	M39456
Pathway	REACTOME_TICAM1_RIP1_MEDIATED_IKK_COMPLEX_RECRUITMENT	IKBKB CHUK	2.54e-03	19	56	2	M27020
Pathway	BIOCARTA_TID_PATHWAY	RB1 IKBKB	2.54e-03	19	56	2	M9546
Pathway	WP_UROTENSINIIMEDIATED_SIGNALING	CCNE1 IKBKB CHUK	2.58e-03	69	56	3	M48052
Pathway	REACTOME_S_PHASE	CCNE1 RB1 POLE PDS5A	2.67e-03	146	56	4	MM15378
Pathway	KEGG_PANCREATIC_CANCER	RB1 IKBKB CHUK	2.69e-03	70	56	3	M9726
Pathway	KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY	IKBKE IKBKB CHUK	2.80e-03	71	56	3	M15913
Pathway	REACTOME_RHOG_GTPASE_CYCLE	IQGAP2 KALRN MCF2L	2.80e-03	71	56	3	MM15604
Pathway	KEGG_MEDICUS_REFERENCE_TLR1_2_4_NFKB_SIGNALING_PATHWAY	IKBKB CHUK	2.81e-03	20	56	2	M47563
Pathway	KEGG_CHRONIC_MYELOID_LEUKEMIA	RB1 IKBKB CHUK	3.03e-03	73	56	3	M321
Pubmed	A dual-activity topoisomerase complex regulates mRNA translation and turnover.	CCNE1 DIP2A KMT2D KANSL1 ZBED4 KALRN PHF12 POLE CPSF1 DEPDC5 MED13L MCF2L ZC3H7B SH2B2 GPAT4 REXO1 RIC1	8.59e-10	1105	83	17	35748872
Pubmed	The Ret finger protein inhibits signaling mediated by the noncanonical and canonical IkappaB kinase family members.	IKBKE IKBKB CHUK	1.31e-07	5	83	3	16393995
Pubmed	All three IkappaB isoforms and most Rel family members are stably associated with the IkappaB kinase 1/2 complex.	IKBKE IKBKB CHUK	2.61e-07	6	83	3	9914500
Pubmed	NF-kappaB activation upon interaction of HIV-1 envelope glycoproteins with cell surface CD4 involves IkappaB kinases.	IKBKE IKBKB CHUK	2.61e-07	6	83	3	11959143
Pubmed	Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus.	IKBKE IKBKB CHUK	2.61e-07	6	83	3	16177806
Pubmed	Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases.	IKBKE IKBKB CHUK	4.56e-07	7	83	3	12133833
Pubmed	SINTBAD, a novel component of innate antiviral immunity, shares a TBK1-binding domain with NAP1 and TANK.	IKBKE IKBKB CHUK	7.28e-07	8	83	3	17568778
Pubmed	IKK/NF-kappaB regulates skeletal myogenesis via a signaling switch to inhibit differentiation and promote mitochondrial biogenesis.	RB1 IKBKB CHUK	7.28e-07	8	83	3	18299349
Pubmed	Competition between TRAF2 and TRAF6 regulates NF-kappaB activation in human B lymphocytes.	IKBKE IKBKB CHUK	1.09e-06	9	83	3	20449947
Pubmed	Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interleukin-8 transcription.	IKBKE IKBKB CHUK	1.09e-06	9	83	3	15489227
Pubmed	IκB kinase ε phosphorylates TRAF2 to promote mammary epithelial cell transformation.	IKBKE IKBKB CHUK	2.13e-06	11	83	3	23007157
Pubmed	FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia.	RTF1 DIP2A VPS13D DNAH12 KIAA0825 IKBKE CPSF1 MYOM2 RIC1	2.98e-06	497	83	9	36774506
Pubmed	Identification of dynein heavy chain genes expressed in human and mouse testis: chromosomal localization of an axonemal dynein gene.	DNAH12 DNAH17 DNAH1	4.68e-06	14	83	3	9373155
Pubmed	Multiple mouse chromosomal loci for dynein-based motility.	ERBB3 DNAH12 DNAH14 DNAH1	4.97e-06	47	83	4	8812413
Pubmed	Distinct roles for IκB kinases alpha and beta in regulating pulmonary endothelial angiogenic function during late lung development.	IKBKB CHUK	5.63e-06	2	83	2	29993183
Pubmed	IkappaB kinases: kinsmen with different crafts.	IKBKB CHUK	5.63e-06	2	83	2	10232975
Pubmed	IkappaB kinase-alpha and -beta genes are coexpressed in adult and embryonic tissues but localized to different human chromosomes.	IKBKB CHUK	5.63e-06	2	83	2	9813230
Pubmed	V3 loop of human immunodeficiency virus type 1 reduces cyclin E expression and induces G1 arrest in interleukin 2-dependent T cells.	CCNE1 RB1	5.63e-06	2	83	2	9453249
Pubmed	Knockdown of IKK1/2 promotes differentiation of mouse embryonic stem cells into neuroectoderm at the expense of mesoderm.	IKBKB CHUK	5.63e-06	2	83	2	22833419
Pubmed	Differential requirements for IKKalpha and IKKbeta in the differentiation of primary human osteoarthritic chondrocytes.	IKBKB CHUK	5.63e-06	2	83	2	18163512
Pubmed	Deletion of IKK2 in haematopoietic cells of adult mice leads to elevated interleukin-6, neutrophilia and fatal gastrointestinal inflammation.	IKBKB CHUK	5.63e-06	2	83	2	33414459
Pubmed	The role and function of IκKα/β in monocyte impairment.	IKBKB CHUK	5.63e-06	2	83	2	32699255
Pubmed	IKKalpha and IKKbeta each function to regulate NF-kappaB activation in the TNF-induced/canonical pathway.	IKBKB CHUK	5.63e-06	2	83	2	20195534
Pubmed	FBXW10 promotes hepatocarcinogenesis in male patients and mice.	FBXW10B FBXW10	5.63e-06	2	83	2	31400758
Pubmed	The inhibitor of κB kinase β (IKKβ) phosphorylates IκBα twice in a single binding event through a sequential mechanism.	IKBKB CHUK	5.63e-06	2	83	2	36528060
Pubmed	IKKα contributes to UVB-induced VEGF expression by regulating AP-1 transactivation.	IKBKB CHUK	5.63e-06	2	83	2	22169952
Pubmed	Cell type-specific expression of the IkappaB kinases determines the significance of phosphatidylinositol 3-kinase/Akt signaling to NF-kappa B activation.	IKBKB CHUK	5.63e-06	2	83	2	14585846
Pubmed	Epithelial-intrinsic IKKα expression regulates group 3 innate lymphoid cell responses and antibacterial immunity.	IKBKB CHUK	5.63e-06	2	83	2	26371187
Pubmed	The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation.	IKBKB CHUK	5.63e-06	2	83	2	9346241
Pubmed	Vinpocetine inhibits NF-kappaB-dependent inflammation via an IKK-dependent but PDE-independent mechanism.	IKBKB CHUK	5.63e-06	2	83	2	20448200
Pubmed	Elevated FBXW10 drives hepatocellular carcinoma tumorigenesis via AR-VRK2 phosphorylation-dependent GAPDH ubiquitination in male transgenic mice.	FBXW10B FBXW10	5.63e-06	2	83	2	37450367
Pubmed	I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss.	IKBKB CHUK	5.63e-06	2	83	2	15897281
Pubmed	The Sec14 homology domain regulates the cellular distribution and transforming activity of the Rho-specific guanine nucleotide exchange factor Dbs.	MCF2L SEC14L1	5.63e-06	2	83	2	15531584
Pubmed	I-kappa B kinases alpha and beta have distinct roles in regulating murine T cell function.	IKBKB CHUK	5.63e-06	2	83	2	11937522
Pubmed	IKKβ regulates the repair of DNA double-strand breaks induced by ionizing radiation in MCF-7 breast cancer cells.	IKBKB CHUK	5.63e-06	2	83	2	21490922
Pubmed	NF-κB activation coordinated by IKKβ and IKKε enables latent infection of Kaposi's sarcoma-associated herpesvirus.	IKBKE IKBKB	5.63e-06	2	83	2	24155403
Pubmed	Enterovirus 2C Protein Suppresses IKKα Phosphorylation by Recruiting IKKβ and IKKα into Viral Inclusion Bodies.	IKBKB CHUK	5.63e-06	2	83	2	33226912
Pubmed	Genomic profiling in ovarian cancer retreated with platinum based chemotherapy presented homologous recombination deficiency and copy number imbalances of CCNE1 and RB1 genes.	CCNE1 RB1	5.63e-06	2	83	2	31060523
Pubmed	Glycerol-3-phosphate acyltransferases 3 and 4 direct glycerolipid synthesis and affect functionality in activated macrophages.	GPAT3 GPAT4	5.63e-06	2	83	2	30523059
Pubmed	A herpesvirus virulence factor inhibits dendritic cell maturation through protein phosphatase 1 and Ikappa B kinase.	IKBKB CHUK	5.63e-06	2	83	2	21248029
Pubmed	Kinetic mechanisms of IkappaB-related kinases (IKK) inducible IKK and TBK-1 differ from IKK-1/IKK-2 heterodimer.	IKBKB CHUK	5.63e-06	2	83	2	11815618
Pubmed	Triacylglycerol synthesis directed by glycerol-3-phosphate acyltransferases -3 and -4 is required for lipid droplet formation and the modulation of the inflammatory response during macrophage to foam cell transition.	GPAT3 GPAT4	5.63e-06	2	83	2	33260006
Pubmed	Differential regulation of IkappaB kinase alpha and beta by two upstream kinases, NF-kappaB-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1.	IKBKB CHUK	5.63e-06	2	83	2	9520401
Pubmed	Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease.	IKBKB CHUK	5.63e-06	2	83	2	18000063
Pubmed	The IκB Kinases Restrict Human Cytomegalovirus Infection.	IKBKB CHUK	5.63e-06	2	83	2	30760575
Pubmed	GPAT3 and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis.	GPAT3 GPAT4	5.63e-06	2	83	2	20181984
Pubmed	Influenza A virus-encoded NS1 virulence factor protein inhibits innate immune response by targeting IKK.	IKBKB CHUK	5.63e-06	2	83	2	22891964
Pubmed	IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation.	IKBKB CHUK	5.63e-06	2	83	2	9346484
Pubmed	The DNA sequence of human chromosome 22.	GSTT1 ZBED4 KCNJ4 MOV10L1 PISD DEPDC5 ZC3H7B	7.86e-06	300	83	7	10591208
Pubmed	Mutually exclusive mutation profiles define functionally related genes in muscle invasive bladder cancer.	KMT2D RB1	1.69e-05	3	83	2	35073341
Pubmed	Withaferin A disrupts ubiquitin-based NEMO reorganization induced by canonical NF-κB signaling.	IKBKB CHUK	1.69e-05	3	83	2	25304104
Pubmed	IKKalpha and IKKbeta regulation of DNA damage-induced cleavage of huntingtin.	IKBKB CHUK	1.69e-05	3	83	2	19488402
Pubmed	Nuclear factor-κB2/p100 promotes endometrial carcinoma cell survival under hypoxia in a HIF-1α independent manner.	IKBKB CHUK	1.69e-05	3	83	2	21537326
Pubmed	Activation of NF-kappa B by the human T cell leukemia virus type I Tax oncoprotein is associated with ubiquitin-dependent relocalization of I kappa B kinase.	IKBKB CHUK	1.69e-05	3	83	2	17145747
Pubmed	Maximal adamantyl-substituted retinoid-related molecule-induced apoptosis requires NF-κB noncanonical and canonical pathway activation.	IKBKB CHUK	1.69e-05	3	83	2	20671747
Pubmed	IKKβ in myeloid cells controls the host response to lethal and sublethal Francisella tularensis LVS infection.	IKBKB CHUK	1.69e-05	3	83	2	23349802
Pubmed	Dimerization of the I kappa B kinase-binding domain of NEMO is required for tumor necrosis factor alpha-induced NF-kappa B activity.	IKBKB CHUK	1.69e-05	3	83	2	17000764
Pubmed	Inhibition of IkappaB kinase by vaccinia virus virulence factor B14.	IKBKB CHUK	1.69e-05	3	83	2	18266467
Pubmed	KMT2D deficiency disturbs the proliferation and cell cycle activity of dental epithelial cell line (LS8) partially via Wnt signaling.	KMT2D RB1	1.69e-05	3	83	2	34724040
Pubmed	Signal processing by its coil zipper domain activates IKK gamma.	IKBKB CHUK	1.69e-05	3	83	2	18216269
Pubmed	The alpha and beta subunits of IkappaB kinase (IKK) mediate TRAF2-dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNF.	IKBKB CHUK	1.69e-05	3	83	2	11359906
Pubmed	A20 inhibits NF-kappa B activation downstream of multiple Map3 kinases and interacts with the I kappa B signalosome.	IKBKB CHUK	1.69e-05	3	83	2	11594795
Pubmed	Regulation of beta-catenin function by the IkappaB kinases.	IKBKB CHUK	1.69e-05	3	83	2	11527961
Pubmed	Serine 25 phosphorylation inhibits RIPK1 kinase-dependent cell death in models of infection and inflammation.	IKBKB CHUK	1.69e-05	3	83	2	30988283
Pubmed	NEMO binding domain of IKK-2 encompasses amino acids 735-745.	IKBKB CHUK	1.69e-05	3	83	2	16583354
Pubmed	Characterization of the bovine IkappaB kinases (IKK)alpha and IKKbeta, the regulatory subunit NEMO and their substrate IkappaBalpha.	IKBKB CHUK	1.69e-05	3	83	2	12459277
Pubmed	The IkappaB kinase complex: master regulator of NF-kappaB signaling.	IKBKB CHUK	1.69e-05	3	83	2	18626576
Pubmed	GRP78 recognizes EV-F 3D protein and activates NF-κB to repress virus replication by interacting with CHUK/IKBKB.	IKBKB CHUK	1.69e-05	3	83	2	38775480
Pubmed	HIV-1 Vpr protein activates the NF-κB pathway to promote G2/M cell cycle arrest.	IKBKB CHUK	1.69e-05	3	83	2	26676942
Pubmed	Biologic sequelae of I{kappa}B kinase (IKK) inhibition in multiple myeloma: therapeutic implications.	IKBKB CHUK	1.69e-05	3	83	2	19270264
Pubmed	Regulation of p53 family member isoform DeltaNp63alpha by the nuclear factor-kappaB targeting kinase IkappaB kinase beta.	IKBKB CHUK	1.69e-05	3	83	2	20145131
Pubmed	Aminosalicylic acid inhibits IkappaB kinase alpha phosphorylation of IkappaBalpha in mouse intestinal epithelial cells.	IKBKB CHUK	1.69e-05	3	83	2	10593965
Pubmed	Inhibitor of kappaB kinase is required to activate a subset of interferon gamma-stimulated genes.	IKBKB CHUK	1.69e-05	3	83	2	15148408
Pubmed	A role for the NF-κB pathway in cell protection from complement-dependent cytotoxicity.	IKBKB CHUK	1.69e-05	3	83	2	22685314
Pubmed	p38 alpha MAPK inhibits JNK activation and collaborates with IkappaB kinase 2 to prevent endotoxin-induced liver failure.	IKBKB CHUK	1.69e-05	3	83	2	18704119
Pubmed	IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex.	IKBKB CHUK	1.69e-05	3	83	2	9751060
Pubmed	A20-binding inhibitor of nuclear factor-kappaB (NF-kappaB)-2 (ABIN-2) is an activator of inhibitor of NF-kappaB (IkappaB) kinase alpha (IKKalpha)-mediated NF-kappaB transcriptional activity.	IKBKB CHUK	1.69e-05	3	83	2	21784860
Pubmed	RNF8 negatively regulates NF-kappaB signaling by targeting IkappaB kinase: implications for the regulation of inflammation signaling.	IKBKB CHUK	1.69e-05	3	83	2	28499869
Pubmed	Canonical, Non-Canonical and Atypical Pathways of Nuclear Factor кb Activation in Preeclampsia.	IKBKB CHUK	1.69e-05	3	83	2	32759710
Pubmed	Does the expression of cyclin E, pRb, and p21 correlate with prognosis in gastric adenocarcinoma?	CCNE1 RB1	1.69e-05	3	83	2	19058005
Pubmed	Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activation.	IKBKB CHUK	1.69e-05	3	83	2	12612076
Pubmed	Mixed-lineage kinase 3 delivers CD3/CD28-derived signals into the IkappaB kinase complex.	IKBKB CHUK	1.69e-05	3	83	2	10713178
Pubmed	DNA-dependent protein kinase phosphorylation of IkappaB alpha and IkappaB beta regulates NF-kappaB DNA binding properties.	IKBKB CHUK	1.69e-05	3	83	2	9632806
Pubmed	miR-339-5p inhibits alcohol-induced brain inflammation through regulating NF-κB pathway.	IKBKE IKBKB	1.69e-05	3	83	2	25172655
Pubmed	Patterns of cyclin E, retinoblastoma protein, and p21Cip1/WAF1 immunostaining in the oncogenesis of papillary thyroid carcinoma.	CCNE1 RB1	1.69e-05	3	83	2	15709169
Pubmed	The MC159 protein from the molluscum contagiosum poxvirus inhibits NF-κB activation by interacting with the IκB kinase complex.	IKBKB CHUK	1.69e-05	3	83	2	22301546
Pubmed	Activation of the transcription factor c-Maf in T cells is dependent on the CARMA1-IKKβ signaling cascade.	IKBKB CHUK	1.69e-05	3	83	2	24345681
Pubmed	Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site.	IKBKB CHUK	1.69e-05	3	83	2	18462684
Pubmed	IKKalpha, IKKbeta, and NEMO/IKKgamma are each required for the NF-kappa B-mediated inflammatory response program.	IKBKB CHUK	1.69e-05	3	83	2	12221085
Pubmed	The inflammatory kinase IKKα phosphorylates and stabilizes c-Myc and enhances its activity.	IKBKB CHUK	1.69e-05	3	83	2	33461590
Pubmed	Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex.	IKBKB CHUK	1.69e-05	3	83	2	10968790
Pubmed	Direct phosphorylation of NF-kappaB1 p105 by the IkappaB kinase complex on serine 927 is essential for signal-induced p105 proteolysis.	IKBKB CHUK	1.69e-05	3	83	2	11297557
Pubmed	Preimplantation-embryo-specific cell-cycle regulation is attributable to a low expression of retinoblastoma protein rather than its phosphorylation.	CCNE1 RB1	1.69e-05	3	83	2	21519154
Pubmed	Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells.	IKBKB CHUK	1.69e-05	3	83	2	15856023
Pubmed	IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain.	IKBKB CHUK	1.69e-05	3	83	2	10521409
Pubmed	The cyclin D1 high and cyclin E high subgroups of breast cancer: separate pathways in tumorogenesis based on pattern of genetic aberrations and inactivation of the pRb node.	CCNE1 RB1	1.69e-05	3	83	2	12096344
Pubmed	IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2.	IKBKE IKBKB	1.69e-05	3	83	2	11839743
Pubmed	Protein kinase C-associated kinase regulates NF-κB activation through inducing IKK activation.	IKBKB CHUK	1.69e-05	3	83	2	25096806
Pubmed	Epstein-Barr virus-encoded EBNA1 inhibits the canonical NF-kappaB pathway in carcinoma cells by inhibiting IKK phosphorylation.	IKBKB CHUK	1.69e-05	3	83	2	20051109
Pubmed	The catalytic subunits of IkappaB kinase, IKK-1 and IKK-2, contain non-equivalent active sites when expressed as homodimers.	IKBKB CHUK	1.69e-05	3	83	2	12054687
Cytoband	2p24	NBAS DTNB	2.11e-04	12	83	2	2p24
GeneFamily	Dyneins, axonemal	DNAH12 DNAH17 DNAH14 DNAH1	1.64e-07	17	54	4	536
GeneFamily	Glycerol-3-phosphate acyltransferases	GPAT3 GPAT4	5.23e-05	4	54	2	1035
GeneFamily	UPF1 like RNA helicases	SETX MOV10L1	4.73e-04	11	54	2	1169
GeneFamily	WD repeat domain containing\|F-box and WD repeat domain containing	FBXW10B FBXW10	4.73e-04	11	54	2	559
GeneFamily	1-acylglycerol-3-phosphate O-acyltransferases	GPAT3 GPAT4	4.73e-04	11	54	2	46
Coexpression	GSE27241_WT_VS_RORGT_KO_TH17_POLARIZED_CD4_TCELL_TREATED_WITH_DIGOXIN_UP	KANSL1 IQGAP2 RB1 VPS13C POLE DEPDC5 RIC1	1.71e-06	180	83	7	M8239
Coexpression	GILMORE_CORE_NFKB_PATHWAY	IKBKE IKBKB CHUK	8.56e-06	13	83	3	M8804
ToppCell	TCGA-Endometrium-Primary_Tumor-Endometrial_Adenocarcinoma-Endometrioid-1\|TCGA-Endometrium / Sample_Type by Project: Shred V9	RTF1 ZBED4 PREP PDS5A CBARP EPHA7	1.65e-06	193	83	6	c2673d86f7d7b849788036032a93a6d136a70040
Disease	autosomal recessive spinocerebellar ataxia 4 (implicated_via_orthology)	VPS13D VPS13C	2.34e-05	3	83	2	DOID:0111611 (implicated_via_orthology)
Disease	liver cancer (is_implicated_in)	IKBKB CHUK	7.77e-05	5	83	2	DOID:3571 (is_implicated_in)
Disease	Disease Exacerbation	CCNE1 NBAS ERBB3 PREP CPSF1	1.05e-04	165	83	5	C0235874
Disease	muscular atrophy (implicated_via_orthology)	IKBKB CHUK	1.63e-04	7	83	2	DOID:767 (implicated_via_orthology)
Disease	prostate cancer (is_implicated_in)	GSTT1 RB1 IKBKB CHUK	3.39e-04	117	83	4	DOID:10283 (is_implicated_in)
Disease	Heschl's gyrus morphology measurement	KALRN DTNB MYOM2	4.54e-04	53	83	3	EFO_0005852
Disease	Malignant neoplasm of skin	GSTT1 ERBB3 POLE	6.23e-04	59	83	3	C0007114
Disease	Skin Neoplasms	GSTT1 ERBB3 POLE	6.23e-04	59	83	3	C0037286
Disease	Bladder Neoplasm	CCNE1 ERBB3 KMT2D RB1	6.67e-04	140	83	4	C0005695
Disease	Malignant neoplasm of urinary bladder	CCNE1 ERBB3 KMT2D RB1	6.85e-04	141	83	4	C0005684
Disease	JT interval	RTF1 PREP KCNJ4 MYOM2 FHIP1A	6.86e-04	248	83	5	EFO_0007885
Disease	Neoplasm of uncertain or unknown behavior of bladder	ERBB3 RB1	8.02e-04	15	83	2	C0496930
Disease	Benign neoplasm of bladder	ERBB3 RB1	8.02e-04	15	83	2	C0154017
Disease	Carcinoma in situ of bladder	ERBB3 RB1	8.02e-04	15	83	2	C0154091
Disease	Benign neoplasm of stomach	ERBB3 POLE	1.03e-03	17	83	2	C0153943
Disease	Eye Abnormalities	BMPR1A IFT122	1.03e-03	17	83	2	C0015393
Disease	Neoplasm of uncertain or unknown behavior of stomach	ERBB3 POLE	1.03e-03	17	83	2	C0496905
Disease	Carcinoma in situ of stomach	ERBB3 POLE	1.03e-03	17	83	2	C0154060
Disease	Carcinoma of bladder	ERBB3 RB1	1.16e-03	18	83	2	C0699885
Disease	Stomach Neoplasms	NBAS ERBB3 PREP POLE CPSF1	1.53e-03	297	83	5	C0038356
Disease	Stomach Carcinoma	ERBB3 POLE	1.59e-03	21	83	2	C0699791
Disease	Malignant neoplasm of stomach	NBAS ERBB3 PREP POLE CPSF1	1.60e-03	300	83	5	C0024623
Disease	lung squamous cell carcinoma (is_implicated_in)	KMT2D POLE	2.07e-03	24	83	2	DOID:3907 (is_implicated_in)
Disease	Squamous cell carcinoma of esophagus	GSTT1 KMT2D RB1	2.47e-03	95	83	3	C0279626
Disease	Sezary Syndrome	KMT2D RB1	2.62e-03	27	83	2	C0036920
Disease	Alzheimer disease, APOE carrier status	NBAS SETX IQGAP2	2.69e-03	98	83	3	EFO_0007659, MONDO_0004975

Protein segments in the cluster

Peptide	Gene	Start	Entry
KRCWDVHQRLNRAME	CBARP	71	Q8N350
CHMDTIDWRDIVRDR	ERBB3	156	P21860
AEAIKEHERWLAMCI	AMZ1	401	Q400G9
HCVNREDVRLAWIMT	ADGRA3	1046	Q8IWK6
CERGLVKVWHIAMAQ	FBXW10	551	Q5XX13
WLMEVCEVYKLHRET	CCNE1	151	P24864
VREFWRLLAICHTVM	ATP8B3	561	O60423
TAERRHTICSLDWRM	CCM2L	191	Q9NUG4
ERCEHRIMESLAWLS	RB1	551	P06400
WKCQNMLRSHVRELL	PDS5A	506	Q29RF7
ALEQGKWDLCRHMIR	RIC1	966	Q4ADV7
CLMWRVGNLRKSHIV	KCNJ4	201	P48050
CERGLVKVWHIAMAQ	FBXW10B	551	O95170
RLVTFWTSCLEKMHA	DEPDC5	1586	O75140
LLMERASTRDRWLHK	FAM166C	81	A6NJV1
MRAVLTWRDKAEHCI	IFT122	1	Q9HBG6
MVHRVWKECILNRTQ	MED13L	376	Q71F56
VWRALCMTLVKRRDA	MOV10L1	236	Q9BXT6
DVKSMWDDIRLHLRR	KIAA0825	156	Q8IV33
ERWCLEIQIMRRLTH	IKBKB	56	O14920
STKNRERWCHEIQIM	CHUK	51	O15111
MAASRWARKAVVLLC	MESD	1	Q14696
RGLHWVMEVLQATCR	IKBKE	441	Q14164
RIELQEWEHVTCMKT	CPSF1	1091	Q10570
RERCMKAWLLEEESL	PDZD4	426	Q76G19
WKPHCMTVRAVCRRE	FBXO48	76	Q5FWF7
CSWHTLRMRKRAEVE	KALRN	2401	O60229
NATITMCRMRARHWK	DNAH12	766	Q6ZR08
MCRMRARHWKQISEI	DNAH12	771	Q6ZR08
QTVDRHWRDIMKFCA	DNAH12	936	Q6ZR08
HAKCEEMERARWLWT	KANSL1	921	Q7Z3B3
RRWEHLIFMKLCSSV	EVC2	826	Q86UK5
QCIHMDCLRWVKRDS	POLE	401	Q07864
HQLMLDCWQKERAER	EPHA7	866	Q15375
HRAKDWCEELACRMV	NBAS	796	A2RRP1
DVLERVKFSCMAWTH	PREP	166	P48147
DWLREVERSMKASVH	DNAH1	1396	Q9P2D7
IMEVAKERSRARHAW	ESS2	166	Q96DF8
HMMLSQRWAVKERDC	FHIP1A	416	Q05DH4
ACHREVRLLKELWDM	DNAH17	1271	Q9UFH2
AMVKACPHVWFERSE	GPAT3	261	Q53EU6
MVKACPHVWFERSEV	GPAT4	281	Q86UL3
ARLCEDVERKMAREW	DCDC2C	346	A8MYV0
DLRWLVGEMHCQKIA	C7	616	P10643
RWNSDECLRAVLKLM	BMPR1A	486	P36894
KRCNLHLVDIWNMIE	DTNB	46	O60941
SHWITMRVALLCEKN	DNAH14	3491	Q0VDD8
NMCKRDRVSWHLIGL	HEPHL1	636	Q6MZM0
HRRLETSMKWCDEGI	MCF2L	461	O15068
WRHRNVESLCVMETA	FBXL5	496	Q9UKA1
ARAALVKSRDMHWSL	DIP2A	601	Q14689
IDKAREIMCQSLTWR	SEC14L1	291	Q92503
HKECKNMRWDRLSIL	SACM1L	341	Q9NTJ5
HIVRCLGVNWMKEDA	KIF28P	706	B7ZC32
KVVSCMEQLTRSHWE	FAM149B1	281	Q96BN6
CMKVHQDSARRDRWS	MROH5	41	Q6ZUA9
LRRSCLRALWHKVMF	GSTT1	106	P30711
RVRLSRHKLERWCHM	RTF1	361	Q92541
DAGACMHLVIWKVRE	REXO1	1201	Q8N1G1
WMITECRDKKHQRTL	MRPS7	186	Q9Y2R9
AREKRGEHLSWLCMF	SV2C	271	Q496J9
KNWDHILCAIERMII	TMCC3	461	Q9ULS5
LMRRDQVLKVCANHW	RGPD2	1091	P0DJD1
LCHLEEAKRWMEVCL	IQGAP2	41	Q13576
EWMCHRCTVRRKKRE	PHF12	96	Q96QT6
HCFMVILDRLGSKVW	SETX	291	Q7Z333
HKETRCTLMRRGDNW	THNSL2	446	Q86YJ6
CAWNRKALLHRDTML	NDUFAF5	266	Q5TEU4
LRDCNVAIRWLMLHT	WASHC5	366	Q12768
ERLSHMMERKAWCSQ	ZNF568	16	Q3ZCX4
LAKVSHMTSDRRQWC	STX10	216	O60499
MARWIKELFCHNERV	PISD	291	Q9UG56
MDKTVRLWHISRREC	WDR44	626	Q5JSH3
ELLERKAVAWMRAHA	VWA5A	746	O00534
WKEELHRSREVRCML	VPS13C	2611	Q709C8
SLCVVDGVRDMWHRR	SH2B2	141	O14492
CADKLQRLEESMHRW	VPS37D	96	Q86XT2
WLTCFLRHERIHMRE	ZNF443	571	Q9Y2A4
LKFIRKMTSRHWCAV	TARBP1	471	Q13395
WHVRIAIRMELLECV	RS1	206	O15537
MWHIVDKCTELLREG	ZBTB22	136	O15209
RHCWTKERRVLLVMS	ZC3H7B	721	Q9UGR2
CLIRHMWRAHRAIVL	ZBED4	326	O75132
REQRKRCTWDFMLHR	VPS13D	331	Q5THJ4
EEDLLIQCRHCERWM	KMT2D	1516	O14686
RSHTVWERMSVKLCF	MYOM2	161	P54296