Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	peptidase activity	USP36 CELA2B TNFAIP3 ADAM11 SPG7 HPR CELA2A OTUD7B	3.18e-05	654	39	8	GO:0008233
GeneOntologyMolecularFunction	hemoglobin binding	CUBN HPR	2.02e-04	11	39	2	GO:0030492
GeneOntologyMolecularFunction	K48-linked deubiquitinase activity	USP36 OTUD7B	7.62e-04	21	39	2	GO:1990380
GeneOntologyMolecularFunction	K63-linked polyubiquitin modification-dependent protein binding	TNFAIP3 OTUD7B	1.17e-03	26	39	2	GO:0070530
GeneOntologyMolecularFunction	endopeptidase activity	CELA2B ADAM11 SPG7 HPR CELA2A	1.43e-03	430	39	5	GO:0004175
GeneOntologyMolecularFunction	cysteine-type deubiquitinase activity	USP36 TNFAIP3 OTUD7B	1.43e-03	114	39	3	GO:0004843
GeneOntologyMolecularFunction	deubiquitinase activity	USP36 TNFAIP3 OTUD7B	1.81e-03	124	39	3	GO:0101005
GeneOntologyMolecularFunction	ubiquitin-like protein peptidase activity	USP36 TNFAIP3 OTUD7B	2.41e-03	137	39	3	GO:0019783
GeneOntologyMolecularFunction	frizzled binding	WNT5B WNT3	3.05e-03	42	39	2	GO:0005109
GeneOntologyMolecularFunction	cytokine binding	LTBP3 IL22RA1 PRLR	3.54e-03	157	39	3	GO:0019955
GeneOntologyBiologicalProcess	embryo development	WNT5B TNFAIP3 CUBN CPLANE1 WNT3 DISP1 PLXNA2 KDM1A TP53BP2 EGLN1 OTUD7B MIB1	8.34e-06	1437	39	12	GO:0009790
GeneOntologyBiologicalProcess	protein deubiquitination involved in ubiquitin-dependent protein catabolic process	TNFAIP3 OTUD7B	9.68e-05	8	39	2	GO:0071947
GeneOntologyBiologicalProcess	limb bud formation	WNT3 PLXNA2	1.24e-04	9	39	2	GO:0060174
GeneOntologyBiologicalProcess	protein K11-linked deubiquitination	TNFAIP3 OTUD7B	1.55e-04	10	39	2	GO:0035871
GeneOntologyBiologicalProcess	regulation of mesenchymal stem cell differentiation	LTBP3 WNT3	1.90e-04	11	39	2	GO:2000739
GeneOntologyBiologicalProcess	stem cell proliferation	MKI67 LTBP3 WNT3 KDM1A	2.11e-04	156	39	4	GO:0072089
GeneOntologyCellularComponent	keratohyalin granule	CELA2B CELA2A	3.38e-05	5	39	2	GO:0036457
GeneOntologyCellularComponent	extracellular matrix	WNT5B LTBP3 CELA2B ADAM11 WNT3 PLXNA2 CELA2A	1.86e-04	656	39	7	GO:0031012
GeneOntologyCellularComponent	external encapsulating structure	WNT5B LTBP3 CELA2B ADAM11 WNT3 PLXNA2 CELA2A	1.90e-04	658	39	7	GO:0030312
GeneOntologyCellularComponent	collagen-containing extracellular matrix	WNT5B LTBP3 CELA2B ADAM11 PLXNA2 CELA2A	4.14e-04	530	39	6	GO:0062023
Domain	Znf_A20	TNFAIP3 OTUD7B	7.54e-05	7	36	2	IPR002653
Domain	ZF_A20	TNFAIP3 OTUD7B	7.54e-05	7	36	2	PS51036
Domain	ZnF_A20	TNFAIP3 OTUD7B	7.54e-05	7	36	2	SM00259
Domain	zf-A20	TNFAIP3 OTUD7B	7.54e-05	7	36	2	PF01754
Domain	OTU	TNFAIP3 OTUD7B	2.78e-04	13	36	2	PF02338
Domain	OTU	TNFAIP3 OTUD7B	3.73e-04	15	36	2	PS50802
Domain	OTU_dom	TNFAIP3 OTUD7B	3.73e-04	15	36	2	IPR003323
Domain	Wnt	WNT5B WNT3	6.05e-04	19	36	2	IPR005817
Domain	WNT1	WNT5B WNT3	6.05e-04	19	36	2	SM00097
Domain	Wnt_CS	WNT5B WNT3	6.05e-04	19	36	2	IPR018161
Domain	wnt	WNT5B WNT3	6.05e-04	19	36	2	PF00110
Domain	WNT1	WNT5B WNT3	6.05e-04	19	36	2	PS00246
Domain	Peptidase_S1A	CELA2B HPR CELA2A	1.33e-03	113	36	3	IPR001314
Domain	TRYPSIN_DOM	CELA2B HPR CELA2A	1.40e-03	115	36	3	PS50240
Domain	Tryp_SPc	CELA2B HPR CELA2A	1.47e-03	117	36	3	SM00020
Domain	Trypsin	CELA2B HPR CELA2A	1.62e-03	121	36	3	PF00089
Domain	Trypsin_dom	CELA2B HPR CELA2A	1.62e-03	121	36	3	IPR001254
Domain	Peptidase_S1_PA	CELA2B HPR CELA2A	1.70e-03	123	36	3	IPR009003
Domain	CUB	CUBN DCBLD2	4.01e-03	49	36	2	PF00431
Domain	CUB	CUBN DCBLD2	4.18e-03	50	36	2	SM00042
Domain	-	CUBN DCBLD2	4.51e-03	52	36	2	2.60.120.290
Domain	CUB	CUBN DCBLD2	4.68e-03	53	36	2	PS01180
Domain	CUB_dom	CUBN DCBLD2	5.39e-03	57	36	2	IPR000859
Domain	Ank_2	TRPV5 TP53BP2 MIB1	8.12e-03	215	36	3	PF12796
Domain	Ank	TRPV5 TP53BP2 MIB1	9.53e-03	228	36	3	PF00023
Domain	EGF_3	LTBP3 ADAM11 CUBN	1.03e-02	235	36	3	PS50026
Domain	EGF	LTBP3 ADAM11 CUBN	1.03e-02	235	36	3	SM00181
Domain	EGF_CA	LTBP3 CUBN	1.19e-02	86	36	2	PF07645
Domain	-	TRPV5 TP53BP2 MIB1	1.20e-02	248	36	3	1.25.40.20
Domain	EGF-like_dom	LTBP3 ADAM11 CUBN	1.21e-02	249	36	3	IPR000742
Domain	ANK	TRPV5 TP53BP2 MIB1	1.24e-02	251	36	3	SM00248
Domain	ANK_REPEAT	TRPV5 TP53BP2 MIB1	1.26e-02	253	36	3	PS50088
Domain	Ankyrin_rpt-contain_dom	TRPV5 TP53BP2 MIB1	1.28e-02	254	36	3	IPR020683
Domain	ANK_REP_REGION	TRPV5 TP53BP2 MIB1	1.28e-02	254	36	3	PS50297
Domain	EGF_1	LTBP3 ADAM11 CUBN	1.29e-02	255	36	3	PS00022
Domain	TRYPSIN_SER	CELA2B CELA2A	1.30e-02	90	36	2	IPR033116
Domain	EGF-like_CS	LTBP3 ADAM11 CUBN	1.37e-02	261	36	3	IPR013032
Domain	Ankyrin_rpt	TRPV5 TP53BP2 MIB1	1.39e-02	262	36	3	IPR002110
Domain	EGF_2	LTBP3 ADAM11 CUBN	1.43e-02	265	36	3	PS01186
Domain	EGF_Ca-bd_CS	LTBP3 CUBN	1.50e-02	97	36	2	IPR018097
Pathway	BIOCARTA_PEPI_PATHWAY	CELA2B CELA2A	7.94e-05	7	28	2	MM1589
Pathway	BIOCARTA_PEPI_PATHWAY	CELA2B CELA2A	1.06e-04	8	28	2	M22084
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_WNT_ACYLATION	WNT5B WNT3	6.37e-04	19	28	2	M47836
Pathway	REACTOME_TNFR1_INDUCED_PROAPOPTOTIC_SIGNALING	TNFAIP3 OTUD7B	9.38e-04	23	28	2	MM15177
Pathway	REACTOME_WNT_LIGAND_BIOGENESIS_AND_TRAFFICKING	WNT5B WNT3	1.11e-03	25	28	2	MM14940
Pathway	REACTOME_TNFR1_INDUCED_PROAPOPTOTIC_SIGNALING	TNFAIP3 OTUD7B	1.11e-03	25	28	2	M27435
Pathway	REACTOME_WNT_LIGAND_BIOGENESIS_AND_TRAFFICKING	WNT5B WNT3	1.20e-03	26	28	2	M27239
Pathway	KEGG_MEDICUS_REFERENCE_WNT_SIGNALING_MODULATION_WNT_INHIBITOR	WNT5B WNT3	1.39e-03	28	28	2	M47835
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_INACTIVATED_PTCH1_TO_HEDGEHOG_SIGNALING_PATHWAY	WNT5B WNT3	1.49e-03	29	28	2	M47372
Pathway	KEGG_MEDICUS_VARIANT_MUTATION_ACTIVATED_SMO_TO_HEDGEHOG_SIGNALING_PATHWAY	WNT5B WNT3	1.49e-03	29	28	2	M47377
Pathway	REACTOME_OVARIAN_TUMOR_DOMAIN_PROTEASES	TNFAIP3 OTUD7B	1.82e-03	32	28	2	MM15290
Pathway	REACTOME_TNFR1_INDUCED_NF_KAPPA_B_SIGNALING_PATHWAY	TNFAIP3 OTUD7B	1.93e-03	33	28	2	M27438
Pathway	REACTOME_TNFR1_INDUCED_NF_KAPPA_B_SIGNALING_PATHWAY	TNFAIP3 OTUD7B	1.93e-03	33	28	2	MM15180
Pubmed	Pdk1 activity controls proliferation, survival, and growth of developing pancreatic cells.	MKI67 CELA2B CELA2A	7.23e-07	16	39	3	19635472
Pubmed	Elastase-2, a Tissue Alternative Pathway for Angiotensin II Generation, Plays a Role in Circulatory Sympathovagal Balance in Mice.	CELA2B CELA2A	1.23e-06	2	39	2	28386233
Pubmed	The Clock-Controlled lncRNA-AK028245 Participates in the Immune Response via Immune Response Factors OTUD7B and A20.	TNFAIP3 OTUD7B	1.23e-06	2	39	2	32748687
Pubmed	Inactivity of recombinant ELA2B provides a new example of evolutionary elastase silencing in humans.	CELA2B CELA2A	1.23e-06	2	39	2	16327289
Pubmed	Characterization of pancreatic elastase II cDNAs: two elastase II mRNAs are expressed in human pancreas.	CELA2B CELA2A	1.23e-06	2	39	2	3646943
Pubmed	Mesenchymal-transitioned cancer cells instigate the invasion of epithelial cancer cells through secretion of WNT3 and WNT5B.	WNT5B WNT3	1.23e-06	2	39	2	24344732
Pubmed	Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.	TNFAIP3 OTUD7B	3.67e-06	3	39	2	27732584
Pubmed	Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity.	TNFAIP3 OTUD7B	3.67e-06	3	39	2	14748687
Pubmed	Primary structure of human pancreatic elastase 2 determined by sequence analysis of the cloned mRNA.	CELA2B CELA2A	3.67e-06	3	39	2	3427074
Pubmed	Hypoxia-inducible factor prolyl-4-hydroxylation in FOXD1 lineage cells is essential for normal kidney development.	CUBN TRPV5 EGLN1	4.19e-06	28	39	3	28847650
Pubmed	KDM2B regulates hippocampal morphogenesis by transcriptionally silencing Wnt signaling in neural progenitors.	MKI67 WNT5B WNT3	5.73e-06	31	39	3	37838801
Pubmed	Ubiquitin-specific peptidase 2a (USP2a) deubiquitinates and stabilizes β-catenin.	USP36 TNFAIP3 OTUD7B	6.95e-06	33	39	3	30323974
Pubmed	The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6.	TNFAIP3 OTUD7B	7.34e-06	4	39	2	9928991
Pubmed	Isolation and characterization of two novel A20-like proteins.	TNFAIP3 OTUD7B	7.34e-06	4	39	2	11463333
Pubmed	WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis.	MKI67 WNT5B WNT3	8.32e-06	35	39	3	30940800
Pubmed	Wnt/Rspondin/β-catenin signals control axonal sorting and lineage progression in Schwann cell development.	MKI67 WNT5B WNT3	9.07e-06	36	39	3	24151333
Pubmed	PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord.	ADAM11 CUBN DCBLD2 PLXNA2	9.13e-06	117	39	4	17145500
Pubmed	Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis.	MKI67 TNFAIP3	1.22e-05	5	39	2	21566665
Pubmed	Elastase 2 is expressed in human and mouse epidermis and impairs skin barrier function in Netherton syndrome through filaggrin and lipid misprocessing.	CELA2B CELA2A	1.22e-05	5	39	2	20179351
Pubmed	NFIC regulates ribosomal biology and ER stress in pancreatic acinar cells and restrains PDAC initiation.	MKI67 CELA2B CELA2A	1.45e-05	42	39	3	37353485
Pubmed	Wnt glycoproteins regulate the expression of FoxN1, the gene defective in nude mice.	WNT5B WNT3	1.83e-05	6	39	2	12379851
Pubmed	OTUD7B Deubiquitinates LSD1 to Govern Its Binding Partner Specificity, Homeostasis, and Breast Cancer Metastasis.	KDM1A OTUD7B	1.83e-05	6	39	2	34050636
Pubmed	Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis.	MKI67 WNT5B WNT3	2.04e-05	47	39	3	28813421
Pubmed	The DNA-binding activity of transcription factor PTF1 parallels the synthesis of pancreas-specific mRNAs during mouse development.	CELA2B CELA2A	2.56e-05	7	39	2	2294404
Pubmed	Sequence organisation and transcriptional regulation of the mouse elastase II and trypsin genes.	CELA2B CELA2A	2.56e-05	7	39	2	3641189
Pubmed	Variation in WNT genes expression in different subtypes of chronic lymphocytic leukemia.	WNT5B WNT3	2.56e-05	7	39	2	19863181
Pubmed	Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand.	MKI67 WNT5B WNT3	2.77e-05	52	39	3	23260145
Pubmed	Critical role of the BAF chromatin remodeling complex during murine neural crest development.	MKI67 PLXNA2	3.42e-05	8	39	2	33750945
Pubmed	A new nomenclature for int-1 and related genes: the Wnt gene family.	WNT5B WNT3	4.39e-05	9	39	2	1846319
Pubmed	MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development.	MKI67 CASZ1 WNT3 KDM1A MIB1	4.85e-05	358	39	5	32460013
Pubmed	Mouse Wnt genes exhibit discrete domains of expression in the early embryonic CNS and limb buds.	WNT5B WNT3	5.48e-05	10	39	2	8275860
Pubmed	The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family.	WNT5B WNT3	5.48e-05	10	39	2	10866835
Pubmed	Identification of the hypoxia-inducible factor 2α nuclear interactome in melanoma cells reveals master proteins involved in melanoma development.	MED26 KDM1A EGLN1	5.68e-05	66	39	3	23275444
Pubmed	Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes.	CEP350 NAV1 MED26 KDM1A TP53BP2 MIB1	7.70e-05	645	39	6	25281560
Pubmed	Involvement of Ymer in suppression of NF-kappaB activation by regulated interaction with lysine-63-linked polyubiquitin chain.	TNFAIP3 OTUD7B	8.03e-05	12	39	2	18029035
Pubmed	Cardiac progenitors instruct second heart field fate through Wnts.	WNT5B WNT3	8.03e-05	12	39	2	36649430
Pubmed	Gene trap screening as an effective approach for identification of Wnt-responsive genes in the mouse embryo.	WNT5B WNT3	8.03e-05	12	39	2	15778975
Pubmed	Separate and distinctive roles for Wnt5a in tongue, lingual tissue and taste papilla development.	MKI67 WNT3	9.48e-05	13	39	2	22024319
Pubmed	The G4 resolvase RHAU regulates ventricular trabeculation and compaction through transcriptional and post-transcriptional mechanisms.	MKI67 MIB1	9.48e-05	13	39	2	34838591
Pubmed	The Stat6-regulated KRAB domain zinc finger protein Zfp157 regulates the balance of lineages in mammary glands and compensates for loss of Gata-3.	MKI67 PRLR	1.11e-04	14	39	2	22588720
Pubmed	The stabilization of beta-catenin leads to impaired primordial germ cell development via aberrant cell cycle progression.	MKI67 WNT5B	1.11e-04	14	39	2	17055474
Pubmed	Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins.	TCF20 KDM1A	1.11e-04	14	39	2	9179496
Pubmed	Expression patterns of Wnt genes in mouse gut development.	WNT5B WNT3	1.27e-04	15	39	2	11429295
Pubmed	Long form of latent TGF-beta binding protein 1 (Ltbp1L) is essential for cardiac outflow tract septation and remodeling.	LTBP3 PLXNA2	1.27e-04	15	39	2	17804598
Pubmed	Dynamic expression of chymotrypsin-like elastase 1 over the course of murine lung development.	CELA2B CELA2A	1.27e-04	15	39	2	24793170
Pubmed	A conserved regulatory logic controls temporal identity in mouse neural progenitors.	MKI67 CASZ1	1.27e-04	15	39	2	25654255
Pubmed	Expression and estradiol regulation of Wnt genes in the mouse blastocyst identify a candidate pathway for embryo-maternal signaling at implantation.	WNT5B WNT3	1.27e-04	15	39	2	15044261
Pubmed	Molecular genetic studies of Wnt signaling in the mouse.	WNT5B WNT3	1.46e-04	16	39	2	10585256
Pubmed	The bHLH protein PTF1-p48 is essential for the formation of the exocrine and the correct spatial organization of the endocrine pancreas.	CELA2B CELA2A	1.46e-04	16	39	2	9851981
Pubmed	Signalling through the type 1 insulin-like growth factor receptor (IGF1R) interacts with canonical Wnt signalling to promote neural proliferation in developing brain.	WNT5B WNT3	1.46e-04	16	39	2	22625652
Pubmed	The Wnts.	WNT5B WNT3	1.46e-04	16	39	2	9889131
Pubmed	Craniofacial malformation in R-spondin2 knockout mice.	MKI67 WNT3	1.46e-04	16	39	2	19233133
Pubmed	LIF is essential for ISC function and protects against radiation-induced gastrointestinal syndrome.	MKI67 WNT3	1.46e-04	16	39	2	32719388
Pubmed	Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne.	TNFAIP3 OTUD7B	1.65e-04	17	39	2	20622874
Pubmed	Wnt family proteins are secreted and associated with the cell surface.	WNT5B WNT3	1.65e-04	17	39	2	8167409
Pubmed	Cooperative and independent functions of FGF and Wnt signaling during early inner ear development.	WNT5B WNT3	1.65e-04	17	39	2	26443994
Pubmed	A human MAP kinase interactome.	CEP350 NAV1 TNFAIP3 TCF20 CPLANE1	2.03e-04	486	39	5	20936779
Pubmed	OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis.	TNFAIP3 OTUD7B	2.07e-04	19	39	2	23827681
Pubmed	HIF2α in the uterine stroma permits embryo invasion and luminal epithelium detachment.	MKI67 PRLR	2.07e-04	19	39	2	29911998
Pubmed	HNF4 factors control chromatin accessibility and are redundantly required for maturation of the fetal intestine.	MKI67 CUBN	2.07e-04	19	39	2	31345929
Pubmed	Characterization of Wnt gene expression in developing and postnatal hair follicles and identification of Wnt5a as a target of Sonic hedgehog in hair follicle morphogenesis.	WNT5B WNT3	2.07e-04	19	39	2	11520664
Pubmed	ASPP2 binds Par-3 and controls the polarity and proliferation of neural progenitors during CNS development.	MKI67 TP53BP2	2.07e-04	19	39	2	20619750
Pubmed	Foxg1 Directly Represses Dbx1 to Confine the POA and Subsequently Regulate Ventral Telencephalic Patterning.	MKI67 WNT3	2.30e-04	20	39	2	30843579
Pubmed	Increased expression of Wnt2 and SFRP4 in Tsk mouse skin: role of Wnt signaling in altered dermal fibrillin deposition and systemic sclerosis.	WNT5B WNT3	2.54e-04	21	39	2	17943183
Pubmed	An obligatory role of mind bomb-1 in notch signaling of mammalian development.	MKI67 MIB1	2.54e-04	21	39	2	18043734
Pubmed	Patterns of Wnt pathway activity in the mouse incisor indicate absence of Wnt/beta-catenin signaling in the epithelial stem cells.	WNT5B WNT3	2.54e-04	21	39	2	19806668
Pubmed	Wnt/beta-catenin signaling is required for CNS, but not non-CNS, angiogenesis.	WNT5B WNT3	2.54e-04	21	39	2	19129494
Pubmed	The WNT7b promoter is regulated by TTF-1, GATA6, and Foxa2 in lung epithelium.	WNT5B WNT3	2.54e-04	21	39	2	11914369
Pubmed	Epithelial Wnt10a Is Essential for Tooth Root Furcation Morphogenesis.	WNT5B WNT3	2.54e-04	21	39	2	31914354
Pubmed	Characterization of Wnt signaling components and activation of the Wnt canonical pathway in the murine retina.	WNT5B WNT3	2.79e-04	22	39	2	12815618
Pubmed	Motor neurons with axial muscle projections specified by Wnt4/5 signaling.	WNT5B WNT3	2.79e-04	22	39	2	19285468
Pubmed	Activation of beta-Catenin in mouse prostate causes HGPIN and continuous prostate growth after castration.	WNT5B WNT3	2.79e-04	22	39	2	18991257
Pubmed	Does murine spermatogenesis require WNT signalling? A lesson from Gpr177 conditional knockout mouse models.	WNT5B WNT3	3.05e-04	23	39	2	27362799
Pubmed	Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta3-catenin signaling.	MKI67 WNT3	3.33e-04	24	39	2	19165927
Pubmed	Mycn deficiency underlies the development of orofacial clefts in mice and humans.	MKI67 WNT5B	3.33e-04	24	39	2	34590686
Pubmed	CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs.	MKI67 SPG7	3.62e-04	25	39	2	28188211
Pubmed	A cluster of three long-range enhancers directs regional Shh expression in the epithelial linings.	WNT5B WNT3	3.62e-04	25	39	2	19369396
Pubmed	Suppressing UPR-dependent overactivation of FGFR3 signaling ameliorates SLC26A2-deficient chondrodysplasias.	MKI67 WNT5B	3.91e-04	26	39	2	30685387
Pubmed	The structural role of radial glial endfeet in confining spinal motor neuron somata is controlled by the Reelin and Notch pathways.	PLXNA2 MIB1	3.91e-04	26	39	2	23988635
Pubmed	TFAM is required for maturation of the fetal and adult intestinal epithelium.	MKI67 CUBN	3.91e-04	26	39	2	29684311
Pubmed	Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study.	MKI67 TNFAIP3 HPR TP53BP2	4.13e-04	313	39	4	20800603
Pubmed	Signalling codes for the maintenance and lineage commitment of embryonic gastric epithelial progenitors.	MKI67 WNT5B	4.23e-04	27	39	2	32878924
Pubmed	Activation of the Wnt-beta catenin pathway in a cell population on the surface of the forebrain is essential for the establishment of olfactory axon connections.	WNT5B WNT3	4.23e-04	27	39	2	17804636
Pubmed	Serotonin Regulates Adult β-Cell Mass by Stimulating Perinatal β-Cell Proliferation.	MKI67 PRLR	4.23e-04	27	39	2	31806625
Pubmed	Frizzled 1 and frizzled 2 genes function in palate, ventricular septum and neural tube closure: general implications for tissue fusion processes.	WNT5B WNT3	4.55e-04	28	39	2	20940229
Pubmed	Ectodermal Wnt signaling regulates abdominal myogenesis during ventral body wall development.	WNT5B WNT3	4.55e-04	28	39	2	24394376
Pubmed	The epigenetic modifier Fam208a is required to maintain epiblast cell fitness.	MKI67 WNT3	4.55e-04	28	39	2	28839193
Pubmed	E-cadherin expression on multiple myeloma cells activates tumor-promoting properties in plasmacytoid DCs.	TNFAIP3 KDM1A	4.55e-04	28	39	2	30277474
Pubmed	Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury.	WNT5B WNT3	4.88e-04	29	39	2	22956684
Pubmed	3D representation of Wnt and Frizzled gene expression patterns in the mouse embryo at embryonic day 11.5 (Ts19).	WNT5B WNT3	4.88e-04	29	39	2	18364260
Pubmed	Genetic interactions of the androgen and Wnt/beta-catenin pathways for the masculinization of external genitalia.	WNT5B WNT3	5.23e-04	30	39	2	19282366
Pubmed	Atlas of Wnt and R-spondin gene expression in the developing male mouse lower urogenital tract.	WNT5B WNT3	5.23e-04	30	39	2	21936019
Pubmed	Expression of all Wnt genes and their secreted antagonists during mouse blastocyst and postimplantation development.	WNT5B WNT3	5.23e-04	30	39	2	15880404
Pubmed	Overactive Wnt5a signaling disrupts hair follicle polarity during mouse skin development.	WNT5B WNT3	5.23e-04	30	39	2	36305473
Pubmed	Nkx2-5 regulates cardiac growth through modulation of Wnt signaling by R-spondin3.	WNT3 PLXNA2	5.58e-04	31	39	2	25053429
Pubmed	OTUD6A Is an Aurora Kinase A-Specific Deubiquitinase.	TNFAIP3 OTUD7B	5.95e-04	32	39	2	33669244
Pubmed	Lhx2 is a direct NF-κB target gene that promotes primary hair follicle placode down-growth.	MKI67 TNFAIP3	6.33e-04	33	39	2	26952977
Pubmed	Wnt5a is essential for hippocampal dendritic maintenance and spatial learning and memory in adult mice.	WNT5B WNT3	6.72e-04	34	39	2	28069946
Pubmed	Disruption of mitochondrial complex III in cap mesenchyme but not in ureteric progenitors results in defective nephrogenesis associated with amino acid deficiency.	MKI67 TRPV5	6.72e-04	34	39	2	35341793
Pubmed	BMPR2 is required for postimplantation uterine function and pregnancy maintenance.	MKI67 EGLN1	6.72e-04	34	39	2	23676498
Cytoband	Ensembl 112 genes in cytogenetic band chr1p36	CELA2B IL22RA1 CASZ1 KDM1A CELA2A	2.68e-04	681	39	5	chr1p36
Cytoband	5p13.2	CPLANE1 PRLR	3.22e-04	31	39	2	5p13.2
Cytoband	1q25.2	CEP350 AXDND1	3.22e-04	31	39	2	1q25.2
Cytoband	1p36.21	CELA2B CELA2A	1.33e-03	63	39	2	1p36.21
Cytoband	1q41	DISP1 TP53BP2	1.46e-03	66	39	2	1q41
Cytoband	Ensembl 112 genes in cytogenetic band chr1q41	DISP1 TP53BP2	2.86e-03	93	39	2	chr1q41
Cytoband	Ensembl 112 genes in cytogenetic band chr5p13	CPLANE1 PRLR	6.27e-03	139	39	2	chr5p13
GeneFamily	OTU domain containing	TNFAIP3 OTUD7B	2.08e-04	17	23	2	669
GeneFamily	Wnt family\|Endogenous ligands	WNT5B WNT3	2.61e-04	19	23	2	360
GeneFamily	Ankyrin repeat domain containing	TRPV5 TP53BP2 MIB1	3.44e-03	242	23	3	403
GeneFamily	Armadillo repeat containing\|Protein phosphatase 1 regulatory subunits	MKI67 TP53BP2	2.20e-02	181	23	2	694
ToppCell	BALF-PFMC-Severe-critical_progression_d12-22_with-steroid-Lymphocytic-Lymphocytic_T-CD8-positive,_alpha-beta_T_cell-T_CD8_c13-HAVCR2\|Severe-critical_progression_d12-22_with-steroid / Compartment, severity and other cell annotations on 10x 3' data (130k)	MKI67 WNT5B AXDND1 CASZ1	3.44e-06	118	39	4	bc65345ee8e59fbda60f345696192376cdbf54b8
ToppCell	TCGA-Brain-Primary_Tumor-Low_Grade_Glioma-Astrocytoma-3\|TCGA-Brain / Sample_Type by Project: Shred V9	CCDC168 CELA2B KDM1A CELA2A	8.68e-06	149	39	4	768877bade04ca0321593b8470b5011ad8270431
ToppCell	LPS-IL1RA\|World / V2 postpublication: Rhesus Genome Updated; Treatment groups by lineage, cell_type_level1, cell_type_level2	NAV1 PLXNA2 TP53BP2 MIB1	1.99e-05	184	39	4	c066c2ec4f0f1d6eb183fca5c7bb0cd45c9950dc
ToppCell	367C-Endothelial_cells-Endothelial-E-\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	NAV1 CASZ1 DISP1 PRLR	2.40e-05	193	39	4	5c6b03d6d98aa873fda1a201d44a912246bb5a92
ToppCell	367C-Endothelial_cells-Endothelial-E\|Endothelial_cells / Donor, Lineage, Cell class and subclass (all cells)	NAV1 CASZ1 DISP1 PRLR	2.40e-05	193	39	4	d4b58eee97043b4337ec36c40f9af6499d864df9
Disease	pulse pressure measurement	USP36 NAV1 LTBP3 CELA2B SPG7 CASZ1 KDM1A CELA2A	3.31e-04	1392	38	8	EFO_0005763
Disease	response to radiation, prostate carcinoma, erectile dysfunction	CELA2B CELA2A	1.05e-03	37	38	2	EFO_0001663, EFO_0004234, GO_0009314
Disease	Developmental delay (disorder)	TCF20 KDM1A	1.05e-03	37	38	2	C0424605
Disease	Psoriasis	MKI67 TNFAIP3	2.46e-03	57	38	2	C0033860
Disease	Pustulosis of Palms and Soles	MKI67 TNFAIP3	2.46e-03	57	38	2	C0030246
Disease	cardiovascular disease	USP36 NAV1 CASZ1 HPR	2.76e-03	457	38	4	EFO_0000319
Disease	acute kidney failure (biomarker_via_orthology)	HPR EGLN1	2.82e-03	61	38	2	DOID:3021 (biomarker_via_orthology)
Disease	cholangiocarcinoma (is_marker_for)	MKI67 TNFAIP3	3.10e-03	64	38	2	DOID:4947 (is_marker_for)

Protein segments in the cluster

Peptide	Gene	Start	Entry
KPPNSKISGLLPQGL	CASZ1	766	Q86V15
GSCLFNKPLKLLDPP	ADAM11	431	O75078
NKPLKLLDPPECGNG	ADAM11	436	O75078
KIQLACLPPAGTILP	CELA2A	136	P08217
PQGTCGQIPLPKKLQ	DISP1	1136	Q96F81
GTKPKPAGQQPRVLL	TP53BP2	541	Q13625
GLRGLPPTQTKCKQP	OTUD7B	791	Q6GQQ9
VPPLLKLACGNNVPA	OR10H2	181	O60403
NPLQSPPAQICIKGK	LRCH3	251	Q96II8
CGKPKNPANPVQRIL	HPR	91	P00739
PPLKKLPLGGLLNQG	FER1L4	1081	A9Z1Z3
PIILKGKNLCPPASG	PLXNA2	1161	O75051
PVQKLDLPGNLPGSK	MKI67	2286	P46013
LALSPTGNAKKPPLG	POGK	531	Q9P215
GKPPGPCLQPKASVL	MED26	236	O95402
KKGQSPLDLCPDPNL	MIB1	771	Q86YT6
LCLLLGPLAGAKPVQ	OTOS	11	Q8NHW6
DPLLGKFCGSKRPPN	CUBN	3106	O60494
VLCTLPLGVLKQQPP	KDM1A	621	O60341
KIQLACLPPAGTILP	CELA2B	136	P08218
IPLCQLNGQPRKKGP	CPLANE1	2161	Q9H799
ANAGPCPENLLPPKK	AXDND1	71	Q5T1B0
GPKPEGLLAQLCKRQ	CEP350	941	Q5VT06
PNGQTKPLPALKLAL	EGLN1	181	Q9GZT9
QCPLGLNAKGLPLGI	FAAH2	486	Q6GMR7
KQPCGSNPLPGLTKQ	LTBP3	286	Q9NS15
RPKGQLQKEPPAGSC	IL22RA1	426	Q8N6P7
LLGCQFIPKGRPPKL	DCBLD2	446	Q96PD2
KSGTLKGCLPPLKLQ	CCDC168	3746	Q8NDH2
GAKTPLAPLAPNLGK	NAV1	156	Q8NEY1
RKGPLVTLNKPQGLP	RPUSD3	86	Q6P087
LLLGPPGCGKTLLAK	SPG7	346	Q9UQ90
NKLPKLNSKPGPEGL	TNFAIP3	416	P21580
GKQLCPPGNPSTLEK	SSX4	136	O60224
LLNGQLPPGKPEIFK	PRLR	21	P16471
QPLLCGSIPGLVPKQ	WNT3	41	P56703
PVCSQLPGLSPGQRK	WNT5B	46	Q9H1J7
LPCPLPPLQNKTAKG	TCF20	1936	Q9UGU0
LGLKSQNGCIPPKLP	USP36	496	Q9P275
PKAEGPGSQLQKLLP	TRPV5	6	Q9NQA5