Cluster composition

Functions

Category	Name	IntersectionWithQuery	PValue	GenesInTerm	GenesInQuery	GenesInTermInQuery	ID
GeneOntologyMolecularFunction	serotonin-gated monoatomic cation channel activity	HTR3A HTR3E HTR3C	8.22e-07	5	88	3	GO:0022850
GeneOntologyMolecularFunction	serotonin receptor activity	HTR3A HTR3E HTR3C	1.64e-06	6	88	3	GO:0099589
GeneOntologyMolecularFunction	monoatomic cation channel activity	CACNA1E HTR3A HCN3 HTR3E PKD1 PKD2 HTR3C STING1 ITGAV	2.03e-05	343	88	9	GO:0005261
GeneOntologyMolecularFunction	transmembrane transporter activity	CACNA1E SLC7A13 HTR3A SLC22A4 HCN3 HTR3E PKD1 PKD2 ABCD3 SLC25A44 HTR3C STING1 ITGAV ATP13A2 SLC22A7 SLC27A4	5.13e-05	1180	88	16	GO:0022857
GeneOntologyMolecularFunction	exoribonuclease II activity	HELZ2 ISG20	5.74e-05	3	88	2	GO:0008859
GeneOntologyMolecularFunction	transporter activity	CACNA1E SLC7A13 HTR3A SLC22A4 HCN3 HTR3E PKD1 PKD2 ABCD3 SLC25A44 HTR3C STING1 ITGAV ATP13A2 SLC22A7 SLC27A4	1.45e-04	1289	88	16	GO:0005215
GeneOntologyMolecularFunction	monoatomic ion channel activity	CACNA1E HTR3A HCN3 HTR3E PKD1 PKD2 HTR3C STING1 ITGAV	1.90e-04	459	88	9	GO:0005216
GeneOntologyMolecularFunction	ligand-gated monoatomic cation channel activity	HTR3A HCN3 HTR3E PKD2 HTR3C	3.87e-04	140	88	5	GO:0099094
GeneOntologyMolecularFunction	channel activity	CACNA1E HTR3A HCN3 HTR3E PKD1 PKD2 HTR3C STING1 ITGAV	5.08e-04	525	88	9	GO:0015267
GeneOntologyMolecularFunction	passive transmembrane transporter activity	CACNA1E HTR3A HCN3 HTR3E PKD1 PKD2 HTR3C STING1 ITGAV	5.15e-04	526	88	9	GO:0022803
GeneOntologyMolecularFunction	monoatomic cation transmembrane transporter activity	CACNA1E HTR3A HCN3 HTR3E PKD1 PKD2 HTR3C STING1 ITGAV ATP13A2	6.75e-04	664	88	10	GO:0008324
GeneOntologyMolecularFunction	gated channel activity	CACNA1E HTR3A HCN3 HTR3E PKD2 HTR3C ITGAV	6.85e-04	334	88	7	GO:0022836
GeneOntologyMolecularFunction	excitatory extracellular ligand-gated monoatomic ion channel activity	HTR3A HTR3E HTR3C	8.99e-04	43	88	3	GO:0005231
GeneOntologyMolecularFunction	RNA exonuclease activity	EXOSC6 HELZ2 ISG20	1.03e-03	45	88	3	GO:0004532
GeneOntologyMolecularFunction	U3 snoRNA binding	UTP25 ISG20	1.03e-03	11	88	2	GO:0034511
GeneOntologyMolecularFunction	neuropeptide Y receptor activity	QRFPR PRLHR	1.03e-03	11	88	2	GO:0004983
GeneOntologyMolecularFunction	voltage-gated calcium channel activity	CACNA1E PKD2 ITGAV	1.09e-03	46	88	3	GO:0005245
GeneOntologyMolecularFunction	ligand-gated monoatomic ion channel activity	HTR3A HCN3 HTR3E PKD2 HTR3C	1.64e-03	193	88	5	GO:0015276
GeneOntologyMolecularFunction	phosphatidate phosphatase activity	PLPPR5 PLPPR1	1.69e-03	14	88	2	GO:0008195
GeneOntologyMolecularFunction	ligand-gated channel activity	HTR3A HCN3 HTR3E PKD2 HTR3C	1.79e-03	197	88	5	GO:0022834
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential	HTR3A HTR3E HTR3C	2.04e-03	57	88	3	GO:1904315
GeneOntologyMolecularFunction	carboxylic acid transmembrane transporter activity	SLC7A13 ABCD3 SLC25A44 SLC22A7 SLC27A4	2.23e-03	207	88	5	GO:0046943
GeneOntologyMolecularFunction	organic acid transmembrane transporter activity	SLC7A13 ABCD3 SLC25A44 SLC22A7 SLC27A4	2.27e-03	208	88	5	GO:0005342
GeneOntologyMolecularFunction	neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential	HTR3A HTR3E HTR3C	2.36e-03	60	88	3	GO:0099529
GeneOntologyMolecularFunction	monoatomic ion transmembrane transporter activity	CACNA1E HTR3A HCN3 HTR3E PKD1 PKD2 HTR3C STING1 ITGAV ATP13A2	2.54e-03	793	88	10	GO:0015075
GeneOntologyMolecularFunction	calcium channel activity	CACNA1E PKD1 PKD2 ITGAV	2.55e-03	129	88	4	GO:0005262
GeneOntologyMolecularFunction	long-chain fatty acid transmembrane transporter activity	ABCD3 SLC27A4	2.81e-03	18	88	2	GO:0005324
GeneOntologyMolecularFunction	transmitter-gated channel activity	HTR3A HTR3E HTR3C	2.97e-03	65	88	3	GO:0022835
GeneOntologyMolecularFunction	transmitter-gated monoatomic ion channel activity	HTR3A HTR3E HTR3C	2.97e-03	65	88	3	GO:0022824
GeneOntologyMolecularFunction	RNA nuclease activity	EXOSC6 HELZ2 PIWIL4 ISG20	3.09e-03	136	88	4	GO:0004540
GeneOntologyMolecularFunction	lipid phosphatase activity	PLPPR5 PLPPR1	3.13e-03	19	88	2	GO:0042577
GeneOntologyMolecularFunction	guanyl-nucleotide exchange factor activity	DENND5B PLEKHG4 ITSN2 MCF2 ALS2	3.57e-03	231	88	5	GO:0005085
GeneOntologyMolecularFunction	lipid transmembrane transporter activity	ABCD3 SLC22A7 SLC27A4	4.12e-03	73	88	3	GO:0170055
GeneOntologyMolecularFunction	postsynaptic neurotransmitter receptor activity	HTR3A HTR3E HTR3C	4.44e-03	75	88	3	GO:0098960
GeneOntologyMolecularFunction	calcium ion transmembrane transporter activity	CACNA1E PKD1 PKD2 ITGAV	4.48e-03	151	88	4	GO:0015085
GeneOntologyMolecularFunction	fatty acid transmembrane transporter activity	ABCD3 SLC27A4	4.57e-03	23	88	2	GO:0015245
GeneOntologyMolecularFunction	voltage-gated monoatomic cation channel activity	CACNA1E HCN3 PKD2 ITGAV	4.59e-03	152	88	4	GO:0022843
GeneOntologyMolecularFunction	extracellular ligand-gated monoatomic ion channel activity	HTR3A HTR3E HTR3C	4.78e-03	77	88	3	GO:0005230
GeneOntologyBiologicalProcess	serotonin receptor signaling pathway	HTR3A HTR3E HTR3C	1.29e-05	11	90	3	GO:0007210
GeneOntologyCellularComponent	serotonin-activated cation-selective channel complex	HTR3A HTR3E HTR3C	7.93e-07	5	91	3	GO:1904602
GeneOntologyCellularComponent	serotonin receptor complex	HTR3A HTR3E HTR3C	7.93e-07	5	91	3	GO:0098665
GeneOntologyCellularComponent	polycystin complex	PKD1 PKD2	1.87e-05	2	91	2	GO:0002133
GeneOntologyCellularComponent	cation channel complex	CACNA1E HTR3A HCN3 HTR3E PKD1 PKD2 HTR3C	7.53e-05	235	91	7	GO:0034703
GeneOntologyCellularComponent	migrasome	PKD1 PKD2	6.61e-04	9	91	2	GO:0140494
GeneOntologyCellularComponent	synaptic membrane	CACNA1E HTR3A ABHD17B NRXN2 ITSN2 HTR3E APBA1 HTR3C ADAM22	9.87e-04	583	91	9	GO:0097060
GeneOntologyCellularComponent	monoatomic ion channel complex	CACNA1E HTR3A HCN3 HTR3E PKD1 PKD2 HTR3C	1.32e-03	378	91	7	GO:0034702
GeneOntologyCellularComponent	neurotransmitter receptor complex	HTR3A HTR3E HTR3C	1.35e-03	50	91	3	GO:0098878
GeneOntologyCellularComponent	9+2 non-motile cilium	STRC STRCP1	1.65e-03	14	91	2	GO:0097732
GeneOntologyCellularComponent	kinocilium	STRC STRCP1	1.65e-03	14	91	2	GO:0060091
GeneOntologyCellularComponent	cytoplasmic ubiquitin ligase complex	NEURL2 MARCHF6	1.65e-03	14	91	2	GO:0000153
GeneOntologyCellularComponent	autophagosome	STING1 VPS16 ATP13A2 ENTPD4	1.82e-03	119	91	4	GO:0005776
GeneOntologyCellularComponent	membrane protein complex	CACNA1E PIGA HTR3A HCN3 MARCHF6 HTR3E PKD1 PKD2 MPDZ CASP10 HTR3C STING1 VPS16 ITGAV CDH6	1.96e-03	1498	91	15	GO:0098796
GeneOntologyCellularComponent	autophagosome membrane	STING1 ATP13A2 ENTPD4	1.97e-03	57	91	3	GO:0000421
Domain	-	HTR3A HTR3E HTR3C	1.79e-04	23	90	3	1.20.120.370
Domain	Acetylcholine_rcpt_TM	HTR3A HTR3E HTR3C	1.79e-04	23	90	3	IPR027361
Domain	NEUZ	NEURL2 NEURL1B	2.27e-04	5	90	2	SM00588
Domain	NHR	NEURL2 NEURL1B	2.27e-04	5	90	2	PS51065
Domain	Neuralized	NEURL2 NEURL1B	2.27e-04	5	90	2	PF07177
Domain	NHR_dom	NEURL2 NEURL1B	2.27e-04	5	90	2	IPR006573
Domain	RhoGEF	PLEKHG4 ITSN2 MCF2 ALS2	3.63e-04	70	90	4	PF00621
Domain	DH_2	PLEKHG4 ITSN2 MCF2 ALS2	3.63e-04	70	90	4	PS50010
Domain	DH-domain	PLEKHG4 ITSN2 MCF2 ALS2	3.83e-04	71	90	4	IPR000219
Domain	-	PLEKHG4 ITSN2 MCF2 ALS2	3.83e-04	71	90	4	1.20.900.10
Domain	Orgcat_transp/SVOP	SLC22A4 SLC22A7	8.09e-04	9	90	2	IPR004749
Domain	GDS_CDC24_CS	PLEKHG4 MCF2 ALS2	8.72e-04	39	90	3	IPR001331
Domain	PKD_channel	PKD1 PKD2	1.23e-03	11	90	2	PF08016
Domain	PKD1_2_channel	PKD1 PKD2	1.23e-03	11	90	2	IPR013122
Domain	Neurotransmitter_ion_chnl_CS	HTR3A HTR3E HTR3C	1.33e-03	45	90	3	IPR018000
Domain	Neur_chan_memb	HTR3A HTR3E HTR3C	1.41e-03	46	90	3	PF02932
Domain	Neur_chan_LBD	HTR3A HTR3E HTR3C	1.51e-03	47	90	3	PF02931
Domain	NEUROTR_ION_CHANNEL	HTR3A HTR3E HTR3C	1.51e-03	47	90	3	PS00236
Domain	Neurotrans-gated_channel_TM	HTR3A HTR3E HTR3C	1.51e-03	47	90	3	IPR006029
Domain	-	HTR3A HTR3E HTR3C	1.51e-03	47	90	3	2.70.170.10
Domain	Neur_channel	HTR3A HTR3E HTR3C	1.51e-03	47	90	3	IPR006201
Domain	Neur_chan_lig-bd	HTR3A HTR3E HTR3C	1.51e-03	47	90	3	IPR006202
Domain	-	PLPPR5 PLPPR1	3.34e-03	18	90	2	1.20.144.10
Domain	acidPPc	PLPPR5 PLPPR1	3.34e-03	18	90	2	SM00014
Domain	DH_1	PLEKHG4 MCF2 ALS2	3.49e-03	63	90	3	PS00741
Domain	P_Acid_Pase_2/haloperoxidase	PLPPR5 PLPPR1	4.12e-03	20	90	2	IPR000326
Domain	PAP2	PLPPR5 PLPPR1	4.12e-03	20	90	2	PF01569
Domain	RhoGEF	PLEKHG4 ITSN2 MCF2	4.33e-03	68	90	3	SM00325
Domain	PLAT	DENND5B PKD1	4.54e-03	21	90	2	PS50095
Domain	-	DENND5B PKD1	4.54e-03	21	90	2	2.60.60.20
Domain	PLAT	DENND5B PKD1	4.54e-03	21	90	2	PF01477
Domain	PLAT/LH2_dom	DENND5B PKD1	4.54e-03	21	90	2	IPR001024
Domain	EF_HAND_2	CAPN12 CACNA1E TBC1D9B ITSN2 PKD2	5.20e-03	231	90	5	PS50222
Domain	EF_hand_dom	CAPN12 CACNA1E TBC1D9B ITSN2 PKD2	5.29e-03	232	90	5	IPR002048
Pubmed	Polycystin-1 affects cancer cell behaviour and interacts with mTOR and Jak signalling pathways in cancer cell lines.	MTOR PKD1 PKD2	1.73e-08	3	91	3	31251475
Pubmed	Characterization of the novel human serotonin receptor subunits 5-HT3C,5-HT3D, and 5-HT3E.	HTR3A HTR3E HTR3C	1.73e-07	5	91	3	17392525
Pubmed	Influence of 5-HT3 receptor subunit genes HTR3A, HTR3B, HTR3C, HTR3D and HTR3E on treatment response to antipsychotics in schizophrenia.	HTR3A HTR3E HTR3C	1.73e-07	5	91	3	19794330
Pubmed	A coding variant of the novel serotonin receptor subunit 5-HT3E influences sustained attention in schizophrenia patients.	HTR3A HTR3E HTR3C	1.73e-07	5	91	3	20356718
Pubmed	Two naturally occurring variants of the serotonin receptor gene HTR3C are associated with nausea in pregnancy.	HTR3A HTR3E HTR3C	3.45e-07	6	91	3	20021265
Pubmed	System analysis of gene mutations and clinical phenotype in Chinese patients with autosomal-dominant polycystic kidney disease.	PKD1 PKD2	6.77e-06	2	91	2	27782177
Pubmed	Mutation Analysis of PKD1 and PKD2 Genes in a Large Italian Cohort Reveals Novel Pathogenic Variants Including a Novel Complex Rearrangement.	PKD1 PKD2	6.77e-06	2	91	2	37231942
Pubmed	5-HT3 receptor influences the washing phenotype and visual organization in obsessive-compulsive disorder supporting 5-HT3 receptor antagonists as novel treatment option.	HTR3E HTR3C	6.77e-06	2	91	2	23928294
Pubmed	Investigation of HTR3C mutations for association with 5HT(3) receptor antagonist anti-emetic efficacy.	HTR3A HTR3C	6.77e-06	2	91	2	18681779
Pubmed	Hyperphosphorylation of polycystin-2 at a critical residue in disease reveals an essential role for polycystin-1-regulated dephosphorylation.	PKD1 PKD2	6.77e-06	2	91	2	23390129
Pubmed	Distinct and common developmental expression patterns of the murine Pkd2 and Pkd1 genes.	PKD1 PKD2	6.77e-06	2	91	2	10781953
Pubmed	Polycystin 2 is involved in the nitric oxide production in responding to oscillating fluid shear in MLO-Y4 cells.	PKD1 PKD2	6.77e-06	2	91	2	24268313
Pubmed	Polycystin-1 but not polycystin-2 deficiency causes upregulation of the mTOR pathway and can be synergistically targeted with rapamycin and metformin.	PKD1 PKD2	6.77e-06	2	91	2	24193408
Pubmed	Evidence for pathogenicity of atypical splice mutations in autosomal dominant polycystic kidney disease.	PKD1 PKD2	6.77e-06	2	91	2	19158373
Pubmed	Regulation of mTOR by polycystin-1: is polycystic kidney disease a case of futile repair?	MTOR PKD1	6.77e-06	2	91	2	17102641
Pubmed	Identification of novel single-nucleotide variants altering RNA splicing of PKD1 and PKD2.	PKD1 PKD2	6.77e-06	2	91	2	34257392
Pubmed	A plasma membrane-localized polycystin-1/polycystin-2 complex in endothelial cells elicits vasodilation.	PKD1 PKD2	6.77e-06	2	91	2	35229718
Pubmed	Molecular pathogenesis of ADPKD: the polycystin complex gets complex.	PKD1 PKD2	6.77e-06	2	91	2	15780076
Pubmed	Reduced ciliary polycystin-2 in induced pluripotent stem cells from polycystic kidney disease patients with PKD1 mutations.	PKD1 PKD2	6.77e-06	2	91	2	24009235
Pubmed	Genetic analysis of Iranian autosomal dominant polycystic kidney disease: new insight to haplotype analysis.	PKD1 PKD2	6.77e-06	2	91	2	26950445
Pubmed	Targeted Next Generation Sequencing Revealed Novel Variants in the PKD1 and PKD2 Genes of Iranian Patients with Autosomal Dominant Polycystic Kidney Disease.	PKD1 PKD2	6.77e-06	2	91	2	37543885
Pubmed	Identification of novel mutations and risk assessment of Han Chinese patients with autosomal dominant polycystic kidney disease.	PKD1 PKD2	6.77e-06	2	91	2	29633482
Pubmed	The Polycystin Complex Reveals Its Complexity.	PKD1 PKD2	6.77e-06	2	91	2	30540438
Pubmed	Novel mutations of PKD genes in Chinese patients suffering from autosomal dominant polycystic kidney disease and seeking assisted reproduction.	PKD1 PKD2	6.77e-06	2	91	2	30333007
Pubmed	Down-regulation of polycystin in lymphatic malformations: possible role in the proliferation of lymphatic endothelial cells.	PKD1 PKD2	6.77e-06	2	91	2	28552828
Pubmed	[A Chinese autosomal dominant polycystic kidney disease family probably related to PKD2 gene].	PKD1 PKD2	6.77e-06	2	91	2	16215947
Pubmed	Comprehensive Analysis of PKD1 and PKD2 by Long-Read Sequencing in Autosomal Dominant Polycystic Kidney Disease.	PKD1 PKD2	6.77e-06	2	91	2	38527221
Pubmed	Polycystin-1 negatively regulates Polycystin-2 expression via the aggresome/autophagosome pathway.	PKD1 PKD2	6.77e-06	2	91	2	24459142
Pubmed	Autosomal dominant polycystic kidney disease: comprehensive mutation analysis of PKD1 and PKD2 in 700 unrelated patients.	PKD1 PKD2	6.77e-06	2	91	2	22508176
Pubmed	PKD1 and PKD2 mRNA cis-inhibition drives polycystic kidney disease progression.	PKD1 PKD2	6.77e-06	2	91	2	35965273
Pubmed	Molecular genetics and mechanism of autosomal dominant polycystic kidney disease.	PKD1 PKD2	6.77e-06	2	91	2	10655152
Pubmed	Polycystin-1 and polycystin-2 are involved in the acquisition of aggressive phenotypes in colorectal cancer.	PKD1 PKD2	6.77e-06	2	91	2	25123959
Pubmed	Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene.	PKD1 PKD2	6.77e-06	2	91	2	11593033
Pubmed	[Identification of mutations in PKD1 and PKD2 genes in two Chinese families with autosomal dominant polycystic kidney disease].	PKD1 PKD2	6.77e-06	2	91	2	21983717
Pubmed	The heteromeric PC-1/PC-2 polycystin complex is activated by the PC-1 N-terminus.	PKD1 PKD2	6.77e-06	2	91	2	33164752
Pubmed	Polycystic disease of the liver.	PKD1 PKD2	6.77e-06	2	91	2	15382167
Pubmed	Mutational screening of PKD1 and PKD2 in Indian ADPKD patients identified 95 genetic variants.	PKD1 PKD2	6.77e-06	2	91	2	32823016
Pubmed	Family history of renal disease severity predicts the mutated gene in ADPKD.	PKD1 PKD2	6.77e-06	2	91	2	19443633
Pubmed	Association of Rare Nonsynonymous Variants in PKD1 and PKD2 with Familial Intracranial Aneurysms in a Japanese Population.	PKD1 PKD2	6.77e-06	2	91	2	27567292
Pubmed	A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes.	PKD1 PKD2	6.77e-06	2	91	2	20168298
Pubmed	Genetic Characteristics of Korean Patients with Autosomal Dominant Polycystic Kidney Disease by Targeted Exome Sequencing.	PKD1 PKD2	6.77e-06	2	91	2	31740684
Pubmed	Dual-vector gene therapy restores cochlear amplification and auditory sensitivity in a mouse model of DFNB16 hearing loss.	STRC STRCP1	6.77e-06	2	91	2	34910522
Pubmed	Identified eleven exon variants in PKD1 and PKD2 genes that altered RNA splicing by minigene assay.	PKD1 PKD2	6.77e-06	2	91	2	37468838
Pubmed	Polycystin-1 C-terminal cleavage is modulated by polycystin-2 expression.	PKD1 PKD2	6.77e-06	2	91	2	19491093
Pubmed	Detection of PKD1 and PKD2 Somatic Variants in Autosomal Dominant Polycystic Kidney Cyst Epithelial Cells by Whole-Genome Sequencing.	PKD1 PKD2	6.77e-06	2	91	2	34716216
Pubmed	Polycystin-1 and polycystin-2 are both required to amplify inositol-trisphosphate-induced Ca2+ release.	PKD1 PKD2	6.77e-06	2	91	2	22456092
Pubmed	Proteasomal selection of multiprotein complexes recruited by LIM homeodomain transcription factors.	RLIM LDB2	6.77e-06	2	91	2	17848518
Pubmed	Ganetespib limits ciliation and cystogenesis in autosomal-dominant polycystic kidney disease (ADPKD).	PKD1 PKD2	6.77e-06	2	91	2	29401581
Pubmed	Structure of the human PKD1-PKD2 complex.	PKD1 PKD2	6.77e-06	2	91	2	30093605
Pubmed	A mutation affecting polycystin-1 mediated heterotrimeric G-protein signaling causes PKD.	PKD1 PKD2	6.77e-06	2	91	2	29931260
Pubmed	Polycystic kidney disease: Polycystin-1 and polycystin-2--it's complicated.	PKD1 PKD2	6.77e-06	2	91	2	23567275
Pubmed	Role of polycystins in renal tubulogenesis.	PKD1 PKD2	6.77e-06	2	91	2	12946628
Pubmed	Relationship of Seminal Megavesicles, Prostate Median Cysts, and Genotype in Autosomal Dominant Polycystic Kidney Disease.	PKD1 PKD2	6.77e-06	2	91	2	30230107
Pubmed	Effect of genotype on the severity and volume progression of polycystic liver disease in autosomal dominant polycystic kidney disease.	PKD1 PKD2	6.77e-06	2	91	2	26932689
Pubmed	Somatic inactivation of Pkd2 results in polycystic kidney disease.	PKD1 PKD2	6.77e-06	2	91	2	9568711
Pubmed	Polycystins and Mechanotransduction in Human Disease.	PKD1 PKD2	6.77e-06	2	91	2	31052533
Pubmed	Deciphering Variability of PKD1 and PKD2 in an Italian Cohort of 643 Patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD).	PKD1 PKD2	6.77e-06	2	91	2	27499327
Pubmed	Altered trafficking and stability of polycystins underlie polycystic kidney disease.	PKD1 PKD2	6.77e-06	2	91	2	25365220
Pubmed	Novel PKD1 and PKD2 mutations in Taiwanese patients with autosomal dominant polycystic kidney disease.	PKD1 PKD2	6.77e-06	2	91	2	23985799
Pubmed	Polycystins: inhibiting the inhibitors.	PKD1 PKD2	6.77e-06	2	91	2	16319969
Pubmed	Predictors of autosomal dominant polycystic kidney disease progression.	PKD1 PKD2	6.77e-06	2	91	2	24925719
Pubmed	Molecular advances in autosomal dominant polycystic kidney disease.	PKD1 PKD2	6.77e-06	2	91	2	20219615
Pubmed	Quantifying the interaction of the C-terminal regions of polycystin-2 and polycystin-1 attached to a lipid bilayer by means of QCM.	PKD1 PKD2	6.77e-06	2	91	2	20206434
Pubmed	A comprehensive search for mutations in the PKD1 and PKD2 in Japanese subjects with autosomal dominant polycystic kidney disease.	PKD1 PKD2	6.77e-06	2	91	2	24611717
Pubmed	Mutations in a new gene encoding a protein of the hair bundle cause non-syndromic deafness at the DFNB16 locus.	STRC STRCP1	6.77e-06	2	91	2	11687802
Pubmed	Protein kinase D1 and D2 are involved in chemokine release induced by toll-like receptors 2, 4, and 5.	PKD1 PKD2	6.77e-06	2	91	2	20557879
Pubmed	Polycystin-1 surface localization is stimulated by polycystin-2 and cleavage at the G protein-coupled receptor proteolytic site.	PKD1 PKD2	6.77e-06	2	91	2	20980620
Pubmed	Trans-heterozygous Pkd1 and Pkd2 mutations modify expression of polycystic kidney disease.	PKD1 PKD2	6.77e-06	2	91	2	12140187
Pubmed	A polycystin multiprotein complex constitutes a cholesterol-containing signalling microdomain in human kidney epithelia.	PKD1 PKD2	6.77e-06	2	91	2	16038619
Pubmed	A role for polycystin-1 and polycystin-2 in neural progenitor cell differentiation.	PKD1 PKD2	6.77e-06	2	91	2	30895336
Pubmed	Polycystin-1 and -2 dosage regulates pressure sensing.	PKD1 PKD2	6.77e-06	2	91	2	19879844
Pubmed	Expression of PKD1 and PKD2 transcripts and proteins in human embryo and during normal kidney development.	PKD1 PKD2	6.77e-06	2	91	2	11891195
Pubmed	Polycystin-1 maturation requires polycystin-2 in a dose-dependent manner.	PKD1 PKD2	6.77e-06	2	91	2	25574838
Pubmed	Loss of polycystins suppresses deciliation via the activation of the centrosomal integrity pathway.	PKD1 PKD2	6.77e-06	2	91	2	32651191
Pubmed	Technical Evaluation: Identification of Pathogenic Mutations in PKD1 and PKD2 in Patients with Autosomal Dominant Polycystic Kidney Disease by Next-Generation Sequencing and Use of a Comprehensive New Classification System.	PKD1 PKD2	6.77e-06	2	91	2	27835667
Pubmed	Growth Pattern of Kidney Cyst Number and Volume in Autosomal Dominant Polycystic Kidney Disease.	PKD1 PKD2	6.77e-06	2	91	2	31088850
Pubmed	Novel mutations of PKD genes in the Czech population with autosomal dominant polycystic kidney disease.	PKD1 PKD2	6.77e-06	2	91	2	24694054
Pubmed	Identification of novel PKD1 and PKD2 mutations in a Chinese population with autosomal dominant polycystic kidney disease.	PKD1 PKD2	6.77e-06	2	91	2	26632257
Pubmed	Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2.	PKD1 PKD2	6.77e-06	2	91	2	9192675
Pubmed	Novel Mutations in the PKD1 and PKD2 Genes of Chinese Patients with Autosomal Dominant Polycystic Kidney Disease.	PKD1 PKD2	6.77e-06	2	91	2	29529603
Pubmed	PKD1 interacts with PKD2 through a probable coiled-coil domain.	PKD1 PKD2	6.77e-06	2	91	2	9171830
Pubmed	The polycystin complex mediates Wnt/Ca(2+) signalling.	PKD1 PKD2	6.77e-06	2	91	2	27214281
Pubmed	Cyst formation in ADPKD: new insights from natural and targeted mutants.	PKD1 PKD2	6.77e-06	2	91	2	10193792
Pubmed	Loss of polycystin-1 or polycystin-2 results in dysregulated apolipoprotein expression in murine tissues via alterations in nuclear hormone receptors.	PKD1 PKD2	6.77e-06	2	91	2	16301212
Pubmed	Adult patients with sporadic polycystic kidney disease: the importance of screening for mutations in the PKD1 and PKD2 genes.	PKD1 PKD2	6.77e-06	2	91	2	22367170
Pubmed	Polycystin-1 distribution is modulated by polycystin-2 expression in mammalian cells.	PKD1 PKD2	6.77e-06	2	91	2	12840011
Pubmed	Polycystin-2 induces a conformational change in polycystin-1.	PKD1 PKD2	6.77e-06	2	91	2	23848298
Pubmed	The 5-hydroxytryptamine type 3 (5-HT3) receptor reveals a novel determinant of single-channel conductance.	HTR3E HTR3C	6.77e-06	2	91	2	15157181
Pubmed	Identification of PKD1 and PKD2 gene variants in a cohort of 125 Asian Indian patients of ADPKD.	PKD1 PKD2	6.77e-06	2	91	2	30816285
Pubmed	Deficiency of polycystin-2 reduces Ca2+ channel activity and cell proliferation in ADPKD lymphoblastoid cells.	PKD1 PKD2	6.77e-06	2	91	2	15001556
Pubmed	Structural and molecular basis of the assembly of the TRPP2/PKD1 complex.	PKD1 PKD2	6.77e-06	2	91	2	19556541
Pubmed	Bilineal inheritance of pathogenic PKD1 and PKD2 variants in a Czech family with autosomal dominant polycystic kidney disease - a case report.	PKD1 PKD2	6.77e-06	2	91	2	29973168
Pubmed	Food Restriction Ameliorates the Development of Polycystic Kidney Disease.	PKD1 PKD2	6.77e-06	2	91	2	26538633
Pubmed	Extracellular Loops Are Essential for the Assembly and Function of Polycystin Receptor-Ion Channel Complexes.	PKD1 PKD2	6.77e-06	2	91	2	28154010
Pubmed	Effects of hydration in rats and mice with polycystic kidney disease.	PKD1 PKD2	6.77e-06	2	91	2	25503729
Pubmed	Cellular and subcellular distribution of polycystin-2, the protein product of the PKD2 gene.	PKD1 PKD2	6.77e-06	2	91	2	10770959
Pubmed	Structural model of the TRPP2/PKD1 C-terminal coiled-coil complex produced by a combined computational and experimental approach.	PKD1 PKD2	6.77e-06	2	91	2	21642537
Pubmed	Polycystin-2 is an essential ion channel subunit in the primary cilium of the renal collecting duct epithelium.	PKD1 PKD2	6.77e-06	2	91	2	29443690
Pubmed	A mega-analysis of genome-wide association studies for major depressive disorder.	HTR3E HTR3C ALG3	1.63e-05	19	91	3	22472876
Pubmed	Characterization of PKD protein-positive exosome-like vesicles.	PKD1 PKD2	2.03e-05	3	91	2	19158352
Interaction	CRELD1 interactions	LMF2 HTR3A SLC22A4 ABCD3 ALG3 STING1 ATP13A2	7.29e-06	163	88	7	int:CRELD1
Interaction	SDF2 interactions	NR2C2 ZER1 ALS2 ZRANB1 PTK7	8.15e-06	63	88	5	int:SDF2
Cytoband	3q27.1	HTR3E HTR3C ALG3	2.13e-05	27	91	3	3q27.1
Cytoband	Ensembl 112 genes in cytogenetic band chr1q22	HCN3 PKLR SLC25A44	3.91e-04	71	91	3	chr1q22
Cytoband	1p21.3	ABCD3 PLPPR5	9.57e-04	23	91	2	1p21.3
Cytoband	15q15.3	STRC STRCP1	1.13e-03	25	91	2	15q15.3
Cytoband	Ensembl 112 genes in cytogenetic band chr3q27	HTR3E HTR3C ALG3	2.15e-03	128	91	3	chr3q27
Cytoband	10q26.13	PRLHR ZRANB1	2.61e-03	38	91	2	10q26.13
GeneFamily	5-hydroxytryptamine receptors, ionotropic	HTR3A HTR3E HTR3C	5.06e-07	5	68	3	172
GeneFamily	Pleckstrin homology domain containing\|Rho guanine nucleotide exchange factors\|C2 domain containing	PLEKHG4 ITSN2 MCF2 ALS2	1.11e-04	66	68	4	722
GeneFamily	Phospholipid phosphatase related	PLPPR5 PLPPR1	1.38e-04	5	68	2	1127
GeneFamily	Peptide receptors	QRFPR PRLHR	2.89e-04	7	68	2	220
GeneFamily	EF-hand domain containing	CAPN12 CACNA1E TBC1D9B ITSN2 PKD2	1.40e-03	219	68	5	863
Disease	autosomal dominant polycystic kidney disease (is_implicated_in)	MTOR PKD1 PKD2	1.02e-07	4	88	3	DOID:898 (is_implicated_in)
Disease	autosomal recessive nonsyndromic deafness 16 (implicated_via_orthology)	STRC STRCP1	8.79e-06	2	88	2	DOID:0110471 (implicated_via_orthology)
Disease	Autosomal dominant polycystic kidney disease	PKD1 PKD2	2.63e-05	3	88	2	cv:C0085413
Disease	Intellectual Disability	CACNA1E NRXN2 MTOR TTI2 RLIM UMPS ACY1 BRWD3	5.81e-05	447	88	8	C3714756
Disease	coagulation factor IXAB measurement	MCF2 F9	8.74e-05	5	88	2	EFO_0020264
Disease	renal system measurement, uric acid measurement	NRXN2 PKD2	1.31e-04	6	88	2	EFO_0004742, EFO_0004761
Disease	Polycystic Kidney Diseases	PKD1 PKD2	1.31e-04	6	88	2	C0022680
Disease	Polycystic kidney disease, type 2	PKD1 PKD2	1.83e-04	7	88	2	C2751306
Disease	Polycystic Kidney, Type 1 Autosomal Dominant Disease	PKD1 PKD2	2.43e-04	8	88	2	C0887850
Disease	Polycystic Kidney, Autosomal Dominant	PKD1 PKD2	3.12e-04	9	88	2	C0085413
Disease	Macrocephaly	CACNA1E BRWD3	4.75e-04	11	88	2	C0221355
Disease	intracranial aneurysm (is_implicated_in)	PKD1 PKD2	5.69e-04	12	88	2	DOID:10941 (is_implicated_in)
Disease	pipecolate measurement	PLPPR5 PLEKHM3	6.71e-04	13	88	2	EFO_0021006
Disease	Connective Tissue Diseases	PKD1 PKD2	6.71e-04	13	88	2	C0009782
Disease	autosomal dominant polycystic kidney disease (implicated_via_orthology)	PKD1 PKD2	7.82e-04	14	88	2	DOID:898 (implicated_via_orthology)
Disease	polycystic kidney disease (implicated_via_orthology)	PKD1 PKD2	7.82e-04	14	88	2	DOID:0080322 (implicated_via_orthology)
Disease	autosomal recessive polycystic kidney disease (implicated_via_orthology)	MTOR PKD1	1.03e-03	16	88	2	DOID:0110861 (implicated_via_orthology)
Disease	West Syndrome	PIGA CRH	2.33e-03	24	88	2	C0037769
Disease	ergothioneine measurement	SLC22A4 MPDZ	2.73e-03	26	88	2	EFO_0021163
Disease	creatinine measurement	CAPN12 DENND5B SLC7A13 NRXN2 SLC22A4 PKD2 SLC22A7 BRWD3 FAM135B	2.87e-03	995	88	9	EFO_0004518

Protein segments in the cluster

Peptide	Gene	Start	Entry
PRRRMVEIYLLNLAI	ACKR2	76	O00590
RPFLLVASQRSVRLY	BOP1	591	Q14137
ALVEYVRPLLRGRLR	EXOC3L2	231	Q2M3D2
ARLIKLLRQGYTIRI	CACNA1E	1581	Q15878
VAIRRRPSLYVINLL	HTR3E	241	A5X5Y0
LFPVFLYVVLRARIR	ALS2	1601	Q96Q42
RHVLGRALYLVRIPT	BTBD6	326	Q96KE9
ERRLLLREPRYTLLV	ALG3	31	Q92685
VVIRRRPLFYVVSLL	HTR3A	236	P46098
RLSRQLRRILLPLYE	AICDA	171	Q9GZX7
ERQSIVPLRLIYRSG	ADAM22	46	Q9P0K1
VVAYPTDLNTIRRRL	BRWD3	1181	Q6RI45
VAIRRRPSLYIINLL	HTR3C	241	Q8WXA8
NIRSRRRVVLTGYPL	RAD54L2	481	Q9Y4B4
GRVRRIYPQLLLALL	MROH7	856	Q68CQ1
DTYRLARILVRLPAL	NR2C2	536	P49116
TREQFIALYRLRPLV	QRFPR	21	Q96P65
MQRITRYPLLIRSIL	ITSN2	1351	Q9NZM3
LYQISQRIRARRGLP	ISG20	161	Q96AZ6
DRLIAISRPLRYVTV	OR4D2	121	P58180
LYPVLQQSLVRAARR	EXOSC6	251	Q5RKV6
RLLDLSYNRIQRIPK	LRRC3	116	Q9BY71
TIRQYRELVPRSILA	LDB2	161	O43679
LRPNRGLYQLVRATV	BMP15	121	O95972
YINPLVRRTVRFLGI	PLPPR5	111	Q32ZL2
ALVLQYLRVPLVDRA	F9	366	P00740
RYIRAALSVPQGRVL	DUSP13	121	Q9UII6
LPIYRHLRRFILSVI	MARCHF6	471	O60337
AQLLSRYRPRAAVIA	PKLR	481	P30613
LRRRIFPREYLLQQI	PLEKHM3	626	Q6ZWE6
FFRVLLQQLLLPRRS	CRH	111	P06850
EILLAPRAIRTRYLR	HCN3	156	Q9P1Z3
LLQVYRQLRHPSLIL	FAAP100	866	Q0VG06
YLRIEQFRIPRDRLV	NEURL2	146	Q9BR09
NERLAIARQRIPYRL	NRXN2	211	P58401
PRCVYLLRRAVQLSL	PARP14	891	Q460N5
ILYRNRVPLNEIVIR	ATP13A2	446	Q9NQ11
AASLTLYPRLLRRVV	CAPN12	111	Q6ZSI9
ILQVCQRRRVPRLVY	SDR42E1	106	Q8WUS8
RIRSSVEILRVYLAL	CEP120	251	Q8N960
RAILYRARPVITVNA	ITGAV	461	P06756
IRLYNVRAPTLRTSI	DENND5B	596	Q6ZUT9
TTVLIRRPDLRYQLG	APBA1	746	Q02410
RLRLDSYLLKPVQRI	MCF2	621	P10911
LPTRQRVSLFRNLLY	CASP10	106	Q92851
LLVTVVLFAALRRQR	CDH6	626	P55285
SVRLRGLRPLTEYQV	COL7A1	291	Q02388
NIIIRSVLTRPRFRY	FAM135B	1221	Q49AJ0
ATSPIRRYLDVVLQR	HELZ2	1671	Q9BYK8
RRRLLLVAYVSTLVL	SLC22A7	171	Q9Y694
LLRTLPRRYIIAAVL	SLC22A4	391	Q9H015
IDLNYLRQLRRHLPV	NIT1	296	Q86X76
VRLVRLGRVPYAELL	LIPT2	6	A6NK58
RPAQLRLQVYRLLST	PKD1	601	P98161
YIHIVPAILRVRTRG	OR1N1	216	Q8NGS0
LRKNLSIQRYAVIPL	MTOR	2216	P42345
ALRQPIRSLYRTHVI	SZT2	476	Q5T011
ERYLIPIISINGARR	AK9	1286	Q5TCS8
RIGVAILQRSIRLYA	UTP25	426	Q68CQ4
GYLRLILPELQARIR	STING1	166	Q86WV6
PLRRRISLRLSAYAV	PRLHR	166	P49683
PIRRLRLAAFYSQVL	LMF2	246	Q9BU23
QELIRLLLYLRSIPR	PLEKHG4	226	Q58EX7
ILYRTRFLPLRDIQQ	ENTPD4	531	Q9Y227
IPDLASRRLRIALLY	PIWIL4	131	Q7Z3Z4
IRVSVYPFTLIRTRL	SLC25A44	31	Q96H78
YLNPLLRRIIRFTGV	PLPPR1	116	Q8TBJ4
GRLTALLLQRYPRLT	STRC	781	Q7RTU9
VRDLLPGRRYQLSVI	SNED1	1161	Q8TER0
LRRVLTAYAFRNPTI	TBC1D9B	576	Q66K14
LALRTRYGIRPENVI	ABHD17B	151	Q5VST6
YLVVSGLFLTRLRRP	ABCD3	236	P28288
PSVTLFRQYLRIRTV	ACY1	11	Q03154
PLLRYIFVRERVTII	PIGA	111	P37287
RNINYRSFEPILRLL	ZER1	676	Q7Z7L7
VLRQTPQRVRLTLYR	MPDZ	1696	O75970
NSRILSFVYPIRLVR	SLC27A4	406	Q6P1M0
LLLRRTYARNLPAFV	TTI2	356	Q6NXR4
RTYVSTIRIPIRRIL	RLIM	376	Q9NVW2
QVLLDRLVLRRLYPL	VPS16	451	Q9H269
RLVLRRLYPLAIQIC	VPS16	456	Q9H269
FTQRPIRLYEQVRLR	NEURL1B	71	A8MQ27
IYIDLRGIVSRPRLL	UMPS	36	P11172
IGILRRRYQEPNLSI	SLC7A13	376	Q8TCU3
YENLLLGVPRIRQLR	PKD2	311	Q13563
IRYIVLLRSVRPLRL	TTLL12	471	Q14166
LLRSVRPLRLFVYDV	TTLL12	476	Q14166
GRLTALLLQRYPRLT	STRCP1	781	A6NGW2
ERPRRRAAQVALLYL	GTF3C2	181	Q8WUA4
RLRVAYAPRDLVISI	SIGLEC10	231	Q96LC7
AIQLNPSYIRAILRR	TTC1	181	Q99614
LLLTQVRPRNAGIYR	PTK7	286	Q13308
IFVLAHILRRPIIVY	ZRANB1	526	Q9UGI0
PEVLYRRAVLLQRFI	HECTD3	401	Q5T447